Author: "Guerra, MR" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Guerra, MR"' showing total 109 results

Start Over Author "Guerra, MR"

109 results on '"Guerra, MR"'

1. Hemophilia A in Brazil – epidemiology and treatment developments

Author: Ferreira AA, Leite IC, Bustamante-Teixeira MT, and Guerra MR
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Adriana Aparecida Ferreira,1 Isabel Cristina Gonçalves Leite,2 Maria Teresa Bustamante-Teixeira,2 Maximiliano Ribeiro Guerra2 1Foundation and Center for Hematology and Hemotherapy of Minas Gerais (Hemominas), 2Department of Collective Health, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilAbstract: Hemophilia A is an inherited disorder characterized by deficiency of coagulation factor VIII, which predisposes patients to bleeding events. Treatment is based on replacement of the deficient factor, in a therapeutic or prophylactic manner. Brazil is the country with the third largest population of people with hemophilia, for which the public health system provides free comprehensive care. Maintaining an updated registry of patients, documenting the prevalence of complications, and assessing the effectiveness of resource use are indispensable elements in the design of a well-coordinated national program. According to sociodemographic, clinical, and laboratory data collected by the computerized Brazilian system on coagulopathies, in June 2013, there were 9,122 registered patients with hemophilia A in Brazil, of which 36.1% had a severe form of the disease. Clotting factor inhibitors were present in 7.5%, but 25.7% of records did not provide this type of data. Around 70% of the patients belonged to the economically active population, being between 15 and 59 years old. Infection by the human immunodeficiency virus was present in 23.4% of the patients tested and infection by hepatitis C virus antibodies in 59.3%. Infection by the hepatitis B virus and human T-lymphotropic virus was also reported. The high percentage of incomplete records regarding serological data shows the fragility of the information system to date. There was also no information available on the prevalence of permanent or disabling joint damage. Although few hemophiliacs receive adequate care in developing countries, and despite Brazil exhibiting great social inequalities, the Ministry of Health has made significant advances in the treatment of hemophilia A. The gradual increase in importation of factor VIII concentrate enabled the implementation of primary and secondary modalities of prophylaxis, in addition to the induction of immune tolerance. There are also plans to set up a factory in the country, to ensure Brazilian self-sufficiency in the production of blood products. Keywords: cryoprecipitate, factor VIII, prophylaxis, comprehensive health care, health information system
Published: 2014

2. The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

Author: Khanh, BT, Lang, JJ, Compton, K, Xu, R, Acheson, AR, Henrikson, HJ, Kocarnik, JM, Penberthy, L, Aali, A, Abbas, Q, Abbasi, B, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, AA, Abdoli, G, Abdulkadir, HA, Abedi, A, Abegaz, KH, Abidi, H, Aboagye, RG, Abolhassani, H, Absalan, A, Abtew, YD, Ali, HA, Abu-Gharbieh, E, Achappa, B, Acuna, JM, Addison, D, Addo, IY, Adegboye, OA, Adesina, MA, Adnan, M, Adnani, QES, Advani, SM, Afrin, S, Afzal, MS, Aggarwal, M, Ahinkorah, BO, Ahmad, AR, Ahmad, R, Ahmad, S, Ahmadi, S, Ahmed, H, Ahmed, LA, Ahmed, MB, Rashid, TA, Aiman, W, Ajami, M, Akalu, GT, Akbarzadeh-Khiavi, M, Aklilu, A, Akonde, M, Akunna, CJ, Al Hamad, H, Alahdab, F, Alanezi, FM, Alanzi, TM, Alessy, SA, Algammal, AM, Al-Hanawi, MK, Alhassan, RK, Ali, BA, Ali, L, Ali, SS, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alqalyoobi, S, Al-Raddadi, RM, Al-Rifai, RHH, Al-Sabah, SK, Al-Tammemi, AB, Altawalah, H, Alvis-Guzman, N, Amare, F, Ameyaw, EK, Dehkordi, JJA, Amirzade-Iranaq, MH, Amu, H, Amusa, GA, Ancuceanu, R, Anderson, JA, Animut, YA, Anoushiravani, A, Anoushirvani, AA, Ansari-Moghaddam, A, Ansha, MG, Antony, B, Antwi, MH, Anwar, SL, Anwer, R, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Aremu, O, Argaw, AM, Ariffin, H, Aripov, T, Arshad, M, Al, A, Arulappan, J, Aruleba, RT, Aryannejad, A, Asaad, M, Asemahagn, MA, Asemi, Z, Asghari-Jafarabadi, M, Ashraf, T, Assadi, R, Athar, M, Athari, SS, Null, MMWA, Attia, S, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awedew, AF, Awoke, MA, Awoke, T, Quintanilla, BPA, Ayana, TM, Ayen, SS, Azadi, D, Null, SA, Azami-Aghdash, S, Azanaw, MM, Azangou-Khyavy, M, Jafari, AA, Azizi, H, Azzam, AYY, Babajani, A, Badar, M, Badiye, AD, Baghcheghi, N, Bagheri, N, Bagherieh, S, Bahadory, S, Baig, AA, Baker, JL, Bakhtiari, A, Bakshi, RK, Banach, M, Banerjee, I, Bardhan, M, Barone-Adesi, F, Barra, F, Barrow, A, Bashir, NZ, Bashiri, A, Basu, S, Batiha, A-MM, Begum, A, Bekele, AB, Belay, AS, Belete, MA, Belgaumi, UI, Bell, AW, Belo, L, Benzian, H, Berhie, AY, Bermudez, ANC, Bernabe, E, Bhagavathula, AS, Bhala, N, Bhandari, BB, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, VS, Bhuyan, SS, Bibi, S, Bilchut, AH, Bintoro, BS, Biondi, A, Birega, MGB, Birhan, HE, Bjorge, T, Blyuss, O, Bodicha, BBA, Bolla, SR, Boloor, A, Bosetti, C, Braithwaite, D, Brauer, M, Brenner, H, Briko, AN, Briko, NI, Buchanan, CM, Bulamu, NB, Bustamante-Teixeira, MT, Butt, MH, Butt, NS, Butt, ZA, Caetano dos Santos, FL, Camera, LA, Cao, C, Cao, Y, Carreras, G, Carvalho, M, Cembranel, F, Cerin, E, Chakraborty, PA, Charalampous, P, Chattu, VK, Chimed-Ochir, O, Chirinos-Caceres, JL, Cho, DY, Cho, WCS, Christopher, DJ, Chu, D-T, Chukwu, IS, Cohen, AJ, Conde, J, Cortas, S, Costa, VM, Cruz-Martins, N, Culbreth, GT, Dadras, O, Dagnaw, FT, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Danielewicz, A, An, TMD, Soltani, RDC, Darwesh, AM, Das, S, Davitoiu, DV, Esmaeili, ED, De la Hoz, FP, Debela, SA, Dehghan, A, Demisse, B, Demisse, FW, DenovaGutiA, E, Derakhshani, A, Molla, MD, Dereje, D, Deribe, KS, Desai, R, Desalegn, MD, Dessalegn, FN, Dessalegni, SAA, Dessie, G, Desta, AA, Dewan, SMR, Dharmaratne, SD, Dhimal, M, Dianatinasab, M, Diao, N, Diaz, D, Digesa, LE, Dixit, SG, Doaei, S, Linh, PD, Doku, PN, Dongarwar, D, dos Santos, WM, Driscoll, TR, Dsouza, HL, Durojaiye, OC, Edalati, S, Eghbalian, F, Ehsani-Chimeh, E, Eini, E, Ekholuenetale, M, Ekundayo, TC, Ekwueme, DU, El Tantawi, M, Elbahnasawy, MA, Elbarazi, I, Elghazaly, H, Elhadi, M, El-Huneidi, W, Emamian, MH, Bain, LE, Enyew, DB, Erkhembayar, R, Eshetu, T, Eshrati, B, Eskandarieh, S, Espinosa-Montero, J, Etaee, F, Etemadimanesh, A, Eyayu, T, Ezeonwumelu, IJ, Ezzikouri, S, Fagbamigbe, AF, Fahimi, S, Fakhradiyev, IR, Faraon, EJA, Fares, J, Farmany, A, Farooque, U, Farrokhpour, H, Fasanmi, AO, Fatehizadeh, A, Fatima, W, Fattahi, H, Fekadu, G, Feleke, BE, Ferrari, AA, Ferrero, S, Desideri, LF, Filip, I, Fischer, F, Foroumadi, R, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gaipov, A, Galehdar, N, Gallus, S, Garg, T, Fonseca, MG, Gebremariam, YH, Gebremeskel, TG, Gebremichael, MA, Geda, YF, Gela, YY, Gemeda, BNB, Getachew, M, Getachew, ME, Ghaffari, K, Ghafourifard, M, Ghamari, S-H, Nour, MG, Ghassemi, F, Ghimire, A, Ghith, N, Gholamalizadeh, M, Navashenaq, JG, Ghozy, S, Gilani, SA, Gill, PS, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Godos, J, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Golitaleb, M, Gorini, G, Goulart, BNG, Grosso, G, Guadie, HA, Gubari, MIM, Gudayu, TW, Guerra, MR, Gunawardane, DA, Gupta, B, Gupta, S, Gupta, V, Gupta, VK, Gurara, MK, Guta, A, Habibzadeh, P, Avval, AH, Hafezi-Nejad, N, Ali, AH, Haj-Mirzaian, A, Halboub, ES, Halimi, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Hariri, S, Harlianto, N, Haro, JM, Hartono, RK, Hasaballah, A, Hasan, SMM, Hasani, H, Hashemi, SM, Hassan, AM, Hassanipour, S, Hayat, K, Heidari, G, Heidari, M, Heidarymeybodi, Z, Herrera-Serna, BY, Herteliu, C, Hezam, K, Hiraike, Y, Hlongwa, MM, Holla, R, Holm, M, Horita, N, Hoseini, M, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseinzadeh, A, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Hugo, FN, Humayun, A, Hussain, S, Hussein, NR, Hwang, B-F, Ibitoye, SE, Iftikhar, PM, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Immurana, M, Innos, K, Iranpour, P, Irham, LM, Islam, MS, Islam, RM, Islami, F, Ismail, NE, Isola, G, Iwagami, M, Merin, LJ, Jaiswal, A, Jakovljevic, M, Jalili, M, Jalilian, S, Jamshidi, E, Jang, S-I, Jani, CT, Javaheri, T, Jayarajah, UU, Jayaram, S, Jazayeri, SB, Jebai, R, Jemal, B, Jeong, W, Jha, RP, Jindal, HA, John-Akinola, YO, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jozwiak, JJ, Jarisson, M, Kabir, A, Kacimi, SEO, Kadashetti, V, Kahe, F, Kakodkar, PV, Kalankesh, LR, Kalhor, R, Kamal, VK, Kamangar, F, Kamath, A, Kanchan, T, Kandaswamy, E, Kandel, H, Kang, H, Kanno, GG, Kapoor, N, Kar, SS, Karanth, SD, Karaye, IM, Karch, A, Karimi, A, Kassa, BG, Katoto, PDMC, Kauppila, JH, Kaur, H, Kebede, AG, Keikavoosi-Arani, L, Kejela, GG, Bohan, PMK, Keramati, M, Keykhaei, M, Khajuria, H, Khan, A, Khan, AAK, Khan, EA, Khan, G, Khan, MN, Ab Khan, M, Khanali, J, Khatab, K, Khatatbeh, MM, Khatib, MN, Khayamzadeh, M, Kashani, HRK, Tabari, MAK, Khezeli, M, Khodadost, M, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Klugar, M, Klugarova, J, Kolahi, A-A, Kolkhir, P, Kompani, F, Koul, PA, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, Y, Bicer, BK, Kugbey, N, Kulimbet, M, Kumar, A, Kumar, GA, Kumar, N, Kurmi, OP, Kuttikkattu, A, La Vecchia, C, Lahiri, A, Lal, DK, Lam, J, Lan, Q, Landires, I, Larijani, B, Lasrado, S, Lau, J, Lauriola, P, Ledda, C, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YY, Lee, YH, Legesse, SM, Leigh, J, Leong, E, Li, M-C, Lim, SS, Liu, G, Liu, J, Lo, C-H, Lohiya, A, Lopukhov, PD, Lorenzovici, L, Lotfi, M, Loureiro, JA, Lunevicius, R, Madadizadeh, F, Mafi, AR, Magdeldin, S, Mahjoub, S, Mahmoodpoor, A, Mahmoudi, M, Mahmoudimanesh, M, Mahumud, RA, Majeed, A, Majidpoor, J, Makki, A, Makris, KC, Rad, EM, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mallhi, TH, Mallya, SD, Mamun, MA, Manda, AL, Mansour-Ghanaei, F, Mansouri, B, Mansournia, MA, Mantovani, LG, Martini, S, Martorell, M, Masoudi, S, Masoumi, SZ, Matei, CN, Mathews, E, Mathur, MR, Mathur, V, McKee, M, Meena, JK, Mehmood, K, Nasab, EM, Mehrotra, R, Melese, A, Mendoza, W, Menezes, RG, Mengesha, SD, Mensah, LG, Mentis, A-FA, Mera-Mamian, AYM, Meretoja, TJ, Merid, MW, Mersha, AG, Meselu, BT, Meshkat, M, Mestrovic, T, Jonasson, JM, Miazgowski, T, Michalek, IM, Mijena, GFW, Miller, TR, Mir, SA, Mirinezhad, SK, Mirmoeeni, S, Mirza-Aghazadeh-Attari, M, Mirzaei, H, Mirzaei, HR, Misganaw, AS, Misra, S, AbdulmuhsinMohammad, K, Mohammadi, E, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, A, Mohammed, S, Mohan, S, Mohseni, M, Moka, N, Mokdad, AH, Molassiotis, A, Molokhia, M, Momenzadeh, K, Momtazmanesh, S, Monasta, L, Mons, U, Al Montasir, A, Montazeri, F, Montero, A, Moosavi, MA, Moradi, A, Moradi, Y, Sarabi, MM, Moraga, P, Morawska, L, Morrison, SD, Morze, J, Mosapour, A, Mostafavi, E, Mousavi, SM, Isfahani, HM, Khaneghah, AM, Mpundu-Kaambwa, C, Mubarik, S, Mulita, F, Munblit, D, Munro, SB, Murillo-Zamora, E, Musa, J, Nabhan, AF, Nagarajan, AJ, Nagaraju, SP, Nagel, G, Naghipour, M, Naimzada, MD, Nair, TS, Naqvi, AA, Swamy, SN, Narayana, AI, Nassereldine, H, Natto, ZS, Nayak, BP, Ndejjo, R, Nduaguba, SO, Negash, WW, Nejadghaderi, SA, Nejati, K, Kandel, SN, Huy, VNN, Niazi, RK, Noor, NM, Noori, M, Noroozi, N, Nouraei, H, Nowroozi, A, Nunez-Samudio, V, Nzoputam, CI, Nzoputam, OJ, Oancea, B, Odukoya, OO, Oghenetega, OB, Ogunsakin, RE, Oguntade, AS, Oh, I-H, Okati-Aliabad, H, Okekunle, AP, Olagunju, AT, Olagunju, TO, Olakunde, BO, Olufadewa, II, Omer, E, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Otstavnov, SS, Oulhaj, A, Oumer, B, Owopetu, OF, Oyinloye, BE, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Pakbin, B, Pakshir, K, Pakzad, R, Palicz, T, Pana, A, Pandey, A, Pant, S, Pardhan, S, Park, E-K, Park, S, Patel, J, Pati, S, Paudel, R, Paudel, U, Paun, M, Toroudi, HP, Peng, M, Pereira, J, Pereira, RB, Perna, S, Perumalsamy, N, Pestell, RG, Pezzani, R, Piccinelli, C, Pillay, JD, Piracha, ZZ, Pischon, T, Postma, MJ, Langroudi, AP, Pourshams, A, Pourtaheri, N, Prashant, A, Qadir, MMF, Syed, ZQ, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Raeisi, M, Rafiee, A, Rafiei, A, Raheem, N, Rahim, F, Rahman, MO, Rahman, M, Rahman, MA, Rahmani, AM, Rahmani, S, Rahmanian, V, Rajai, N, Rajesh, A, Ram, P, Ramezanzadeh, K, Rana, J, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rashedi, S, Rashidi, A, Rashidi, M-M, Ratan, ZA, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Razeghinia, MS, Rehman, AU, Rehman, IU, Reitsma, MB, Renzaho, AMN, Rezaei, M, Rezaei, N, Rezaei, S, Rezaeian, M, Rezapour, A, Riad, A, Rikhtegar, R, Rios-Blancas, M, Roberts, TJ, Rohloff, P, Romero-Rodriguez, E, Roshandel, G, Rwegerera, GM, Manjula, S, Saber-Ayad, MM, Saberzadeh-Ardestani, B, Sabour, S, Saddik, B, Sadeghi, E, Saeb, MR, Saeed, U, Safaei, M, Safary, A, Sahebazzamani, M, Sahebkar, A, Sahoo, H, Sajid, MR, Salari, H, Salehi, S, Salem, MR, Salimzadeh, H, Samodra, YL, Samy, AM, Sanabria, J, Sankararaman, S, Sanmarchi, F, Santric-Milicevic, MM, Saqib, MAN, Sarveazad, A, Sarvi, F, Sathian, B, Satpathy, M, Sayegh, N, Schneider, IJC, Schwarzinger, M, Sekerija, M, Senthilkumaran, S, Sepanlou, SG, Seylani, A, Seyoum, K, Sha, F, Shafaat, O, Shah, PA, Shahabi, S, Shahid, I, Shahrbaf, MA, Shahsavari, HR, Shaikh, MA, Shaka, MF, Shaker, E, Shannawaz, M, Sharew, MMS, Sharifi, A, Sharifi-Rad, J, Sharma, P, Shashamo, BB, Sheikh, A, Sheikh, M, Sheikhbahaei, S, Sheikhi, RA, Sheikhy, A, Shepherd, PR, Shetty, A, Shetty, JK, Shetty, RS, Shibuya, K, Shirkoohi, R, Shirzad-Aski, H, Shivakumar, KM, Shivalli, S, Shivarov, V, Shobeiri, P, Varniab, ZS, Shorofi, SA, Shrestha, S, Sibhat, MM, Malleshappa, SS, Sidemo, NB, Silva, DAS, Silva, LMLR, Julian, GS, Silvestris, N, Simegn, W, Singh, AD, Singh, A, Singh, G, Singh, H, Singh, JA, Singh, JK, Singh, P, Singh, S, Sinha, DN, Sinke, AH, Siraj, MS, Sitas, F, Siwal, SS, Skryabin, VY, Skryabina, AA, Socea, B, Soeberg, MJ, Sofi-Mahmudi, A, Solomon, Y, Soltani-Zangbar, MS, Song, S, Song, Y, Sorensen, RJD, Soshnikov, S, Sotoudeh, H, Sowe, A, Sufiyan, MB, Suk, R, Suleman, M, Abdulkader, RS, Sultana, S, Sur, D, Szacska, M, Tabaeian, SP, Tabares-Seisdedos, R, Tabatabaei, SM, Tabuchi, T, Tadbiri, H, Taheri, E, Taheri, M, Soodejani, MT, Takahashi, K, Talaat, IM, Tampa, M, Tan, K-K, Tat, NY, Tat, VY, Tavakoli, A, Tehrani-Banihashemi, A, Tekalegn, Y, Tesfay, FH, Thapar, R, Thavamani, A, Chandrasekar, VT, Thomas, N, Thomas, NK, Ticoalu, JHV, Tiyuri, A, Tollosa, DN, Topor-Madry, R, Touvier, M, Tovani-Palone, MR, Traini, E, Mai, TNT, Tripathy, JP, Ukke, GG, Ullah, I, Ullah, S, Unnikrishnan, B, Vacante, M, Vaezi, M, Tahbaz, SV, Valdez, PR, Vardavas, C, Varthya, SB, Vaziri, S, Velazquez, DZ, Veroux, M, Villeneuve, PJ, Violante, FS, Vladimirov, SK, Vlassov, V, Vo, B, Vu, LG, Wadood, AW, Waheed, Y, Walde, MT, Wamai, RG, Wang, C, Wang, F, Wang, N, Wang, Y, Ward, P, Waris, A, Westerman, R, Wickramasinghe, ND, Woldemariam, M, Woldu, B, Xiao, H, Xu, S, Xu, X, Yadav, L, Jabbari, SHY, Yang, L, Yazdanpanah, F, Yeshaw, Y, Yismaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yousefian, F, Yu, C, Yu, Y, Yunusa, I, Zahir, M, Zaki, N, Zaman, BA, Zangiabadian, M, Zare, F, Zare, I, Zareshahrabadi, Z, Zarrintan, A, Zastrozhin, MS, Zeineddine, MA, Zhang, D, Zhang, J, Zhang, Y, Zhang, Z-J, Zhou, L, Zodpey, S, Zoladl, M, Vos, T, Hay, S, Force, LM, Murray, CJL, Khanh, BT, Lang, JJ, Compton, K, Xu, R, Acheson, AR, Henrikson, HJ, Kocarnik, JM, Penberthy, L, Aali, A, Abbas, Q, Abbasi, B, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, AA, Abdoli, G, Abdulkadir, HA, Abedi, A, Abegaz, KH, Abidi, H, Aboagye, RG, Abolhassani, H, Absalan, A, Abtew, YD, Ali, HA, Abu-Gharbieh, E, Achappa, B, Acuna, JM, Addison, D, Addo, IY, Adegboye, OA, Adesina, MA, Adnan, M, Adnani, QES, Advani, SM, Afrin, S, Afzal, MS, Aggarwal, M, Ahinkorah, BO, Ahmad, AR, Ahmad, R, Ahmad, S, Ahmadi, S, Ahmed, H, Ahmed, LA, Ahmed, MB, Rashid, TA, Aiman, W, Ajami, M, Akalu, GT, Akbarzadeh-Khiavi, M, Aklilu, A, Akonde, M, Akunna, CJ, Al Hamad, H, Alahdab, F, Alanezi, FM, Alanzi, TM, Alessy, SA, Algammal, AM, Al-Hanawi, MK, Alhassan, RK, Ali, BA, Ali, L, Ali, SS, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alqalyoobi, S, Al-Raddadi, RM, Al-Rifai, RHH, Al-Sabah, SK, Al-Tammemi, AB, Altawalah, H, Alvis-Guzman, N, Amare, F, Ameyaw, EK, Dehkordi, JJA, Amirzade-Iranaq, MH, Amu, H, Amusa, GA, Ancuceanu, R, Anderson, JA, Animut, YA, Anoushiravani, A, Anoushirvani, AA, Ansari-Moghaddam, A, Ansha, MG, Antony, B, Antwi, MH, Anwar, SL, Anwer, R, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Aremu, O, Argaw, AM, Ariffin, H, Aripov, T, Arshad, M, Al, A, Arulappan, J, Aruleba, RT, Aryannejad, A, Asaad, M, Asemahagn, MA, Asemi, Z, Asghari-Jafarabadi, M, Ashraf, T, Assadi, R, Athar, M, Athari, SS, Null, MMWA, Attia, S, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awedew, AF, Awoke, MA, Awoke, T, Quintanilla, BPA, Ayana, TM, Ayen, SS, Azadi, D, Null, SA, Azami-Aghdash, S, Azanaw, MM, Azangou-Khyavy, M, Jafari, AA, Azizi, H, Azzam, AYY, Babajani, A, Badar, M, Badiye, AD, Baghcheghi, N, Bagheri, N, Bagherieh, S, Bahadory, S, Baig, AA, Baker, JL, Bakhtiari, A, Bakshi, RK, Banach, M, Banerjee, I, Bardhan, M, Barone-Adesi, F, Barra, F, Barrow, A, Bashir, NZ, Bashiri, A, Basu, S, Batiha, A-MM, Begum, A, Bekele, AB, Belay, AS, Belete, MA, Belgaumi, UI, Bell, AW, Belo, L, Benzian, H, Berhie, AY, Bermudez, ANC, Bernabe, E, Bhagavathula, AS, Bhala, N, Bhandari, BB, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, VS, Bhuyan, SS, Bibi, S, Bilchut, AH, Bintoro, BS, Biondi, A, Birega, MGB, Birhan, HE, Bjorge, T, Blyuss, O, Bodicha, BBA, Bolla, SR, Boloor, A, Bosetti, C, Braithwaite, D, Brauer, M, Brenner, H, Briko, AN, Briko, NI, Buchanan, CM, Bulamu, NB, Bustamante-Teixeira, MT, Butt, MH, Butt, NS, Butt, ZA, Caetano dos Santos, FL, Camera, LA, Cao, C, Cao, Y, Carreras, G, Carvalho, M, Cembranel, F, Cerin, E, Chakraborty, PA, Charalampous, P, Chattu, VK, Chimed-Ochir, O, Chirinos-Caceres, JL, Cho, DY, Cho, WCS, Christopher, DJ, Chu, D-T, Chukwu, IS, Cohen, AJ, Conde, J, Cortas, S, Costa, VM, Cruz-Martins, N, Culbreth, GT, Dadras, O, Dagnaw, FT, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Danielewicz, A, An, TMD, Soltani, RDC, Darwesh, AM, Das, S, Davitoiu, DV, Esmaeili, ED, De la Hoz, FP, Debela, SA, Dehghan, A, Demisse, B, Demisse, FW, DenovaGutiA, E, Derakhshani, A, Molla, MD, Dereje, D, Deribe, KS, Desai, R, Desalegn, MD, Dessalegn, FN, Dessalegni, SAA, Dessie, G, Desta, AA, Dewan, SMR, Dharmaratne, SD, Dhimal, M, Dianatinasab, M, Diao, N, Diaz, D, Digesa, LE, Dixit, SG, Doaei, S, Linh, PD, Doku, PN, Dongarwar, D, dos Santos, WM, Driscoll, TR, Dsouza, HL, Durojaiye, OC, Edalati, S, Eghbalian, F, Ehsani-Chimeh, E, Eini, E, Ekholuenetale, M, Ekundayo, TC, Ekwueme, DU, El Tantawi, M, Elbahnasawy, MA, Elbarazi, I, Elghazaly, H, Elhadi, M, El-Huneidi, W, Emamian, MH, Bain, LE, Enyew, DB, Erkhembayar, R, Eshetu, T, Eshrati, B, Eskandarieh, S, Espinosa-Montero, J, Etaee, F, Etemadimanesh, A, Eyayu, T, Ezeonwumelu, IJ, Ezzikouri, S, Fagbamigbe, AF, Fahimi, S, Fakhradiyev, IR, Faraon, EJA, Fares, J, Farmany, A, Farooque, U, Farrokhpour, H, Fasanmi, AO, Fatehizadeh, A, Fatima, W, Fattahi, H, Fekadu, G, Feleke, BE, Ferrari, AA, Ferrero, S, Desideri, LF, Filip, I, Fischer, F, Foroumadi, R, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gaipov, A, Galehdar, N, Gallus, S, Garg, T, Fonseca, MG, Gebremariam, YH, Gebremeskel, TG, Gebremichael, MA, Geda, YF, Gela, YY, Gemeda, BNB, Getachew, M, Getachew, ME, Ghaffari, K, Ghafourifard, M, Ghamari, S-H, Nour, MG, Ghassemi, F, Ghimire, A, Ghith, N, Gholamalizadeh, M, Navashenaq, JG, Ghozy, S, Gilani, SA, Gill, PS, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Godos, J, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Golitaleb, M, Gorini, G, Goulart, BNG, Grosso, G, Guadie, HA, Gubari, MIM, Gudayu, TW, Guerra, MR, Gunawardane, DA, Gupta, B, Gupta, S, Gupta, V, Gupta, VK, Gurara, MK, Guta, A, Habibzadeh, P, Avval, AH, Hafezi-Nejad, N, Ali, AH, Haj-Mirzaian, A, Halboub, ES, Halimi, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Hariri, S, Harlianto, N, Haro, JM, Hartono, RK, Hasaballah, A, Hasan, SMM, Hasani, H, Hashemi, SM, Hassan, AM, Hassanipour, S, Hayat, K, Heidari, G, Heidari, M, Heidarymeybodi, Z, Herrera-Serna, BY, Herteliu, C, Hezam, K, Hiraike, Y, Hlongwa, MM, Holla, R, Holm, M, Horita, N, Hoseini, M, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseinzadeh, A, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Hugo, FN, Humayun, A, Hussain, S, Hussein, NR, Hwang, B-F, Ibitoye, SE, Iftikhar, PM, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Immurana, M, Innos, K, Iranpour, P, Irham, LM, Islam, MS, Islam, RM, Islami, F, Ismail, NE, Isola, G, Iwagami, M, Merin, LJ, Jaiswal, A, Jakovljevic, M, Jalili, M, Jalilian, S, Jamshidi, E, Jang, S-I, Jani, CT, Javaheri, T, Jayarajah, UU, Jayaram, S, Jazayeri, SB, Jebai, R, Jemal, B, Jeong, W, Jha, RP, Jindal, HA, John-Akinola, YO, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jozwiak, JJ, Jarisson, M, Kabir, A, Kacimi, SEO, Kadashetti, V, Kahe, F, Kakodkar, PV, Kalankesh, LR, Kalhor, R, Kamal, VK, Kamangar, F, Kamath, A, Kanchan, T, Kandaswamy, E, Kandel, H, Kang, H, Kanno, GG, Kapoor, N, Kar, SS, Karanth, SD, Karaye, IM, Karch, A, Karimi, A, Kassa, BG, Katoto, PDMC, Kauppila, JH, Kaur, H, Kebede, AG, Keikavoosi-Arani, L, Kejela, GG, Bohan, PMK, Keramati, M, Keykhaei, M, Khajuria, H, Khan, A, Khan, AAK, Khan, EA, Khan, G, Khan, MN, Ab Khan, M, Khanali, J, Khatab, K, Khatatbeh, MM, Khatib, MN, Khayamzadeh, M, Kashani, HRK, Tabari, MAK, Khezeli, M, Khodadost, M, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Klugar, M, Klugarova, J, Kolahi, A-A, Kolkhir, P, Kompani, F, Koul, PA, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, Y, Bicer, BK, Kugbey, N, Kulimbet, M, Kumar, A, Kumar, GA, Kumar, N, Kurmi, OP, Kuttikkattu, A, La Vecchia, C, Lahiri, A, Lal, DK, Lam, J, Lan, Q, Landires, I, Larijani, B, Lasrado, S, Lau, J, Lauriola, P, Ledda, C, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YY, Lee, YH, Legesse, SM, Leigh, J, Leong, E, Li, M-C, Lim, SS, Liu, G, Liu, J, Lo, C-H, Lohiya, A, Lopukhov, PD, Lorenzovici, L, Lotfi, M, Loureiro, JA, Lunevicius, R, Madadizadeh, F, Mafi, AR, Magdeldin, S, Mahjoub, S, Mahmoodpoor, A, Mahmoudi, M, Mahmoudimanesh, M, Mahumud, RA, Majeed, A, Majidpoor, J, Makki, A, Makris, KC, Rad, EM, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mallhi, TH, Mallya, SD, Mamun, MA, Manda, AL, Mansour-Ghanaei, F, Mansouri, B, Mansournia, MA, Mantovani, LG, Martini, S, Martorell, M, Masoudi, S, Masoumi, SZ, Matei, CN, Mathews, E, Mathur, MR, Mathur, V, McKee, M, Meena, JK, Mehmood, K, Nasab, EM, Mehrotra, R, Melese, A, Mendoza, W, Menezes, RG, Mengesha, SD, Mensah, LG, Mentis, A-FA, Mera-Mamian, AYM, Meretoja, TJ, Merid, MW, Mersha, AG, Meselu, BT, Meshkat, M, Mestrovic, T, Jonasson, JM, Miazgowski, T, Michalek, IM, Mijena, GFW, Miller, TR, Mir, SA, Mirinezhad, SK, Mirmoeeni, S, Mirza-Aghazadeh-Attari, M, Mirzaei, H, Mirzaei, HR, Misganaw, AS, Misra, S, AbdulmuhsinMohammad, K, Mohammadi, E, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, A, Mohammed, S, Mohan, S, Mohseni, M, Moka, N, Mokdad, AH, Molassiotis, A, Molokhia, M, Momenzadeh, K, Momtazmanesh, S, Monasta, L, Mons, U, Al Montasir, A, Montazeri, F, Montero, A, Moosavi, MA, Moradi, A, Moradi, Y, Sarabi, MM, Moraga, P, Morawska, L, Morrison, SD, Morze, J, Mosapour, A, Mostafavi, E, Mousavi, SM, Isfahani, HM, Khaneghah, AM, Mpundu-Kaambwa, C, Mubarik, S, Mulita, F, Munblit, D, Munro, SB, Murillo-Zamora, E, Musa, J, Nabhan, AF, Nagarajan, AJ, Nagaraju, SP, Nagel, G, Naghipour, M, Naimzada, MD, Nair, TS, Naqvi, AA, Swamy, SN, Narayana, AI, Nassereldine, H, Natto, ZS, Nayak, BP, Ndejjo, R, Nduaguba, SO, Negash, WW, Nejadghaderi, SA, Nejati, K, Kandel, SN, Huy, VNN, Niazi, RK, Noor, NM, Noori, M, Noroozi, N, Nouraei, H, Nowroozi, A, Nunez-Samudio, V, Nzoputam, CI, Nzoputam, OJ, Oancea, B, Odukoya, OO, Oghenetega, OB, Ogunsakin, RE, Oguntade, AS, Oh, I-H, Okati-Aliabad, H, Okekunle, AP, Olagunju, AT, Olagunju, TO, Olakunde, BO, Olufadewa, II, Omer, E, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Otstavnov, SS, Oulhaj, A, Oumer, B, Owopetu, OF, Oyinloye, BE, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Pakbin, B, Pakshir, K, Pakzad, R, Palicz, T, Pana, A, Pandey, A, Pant, S, Pardhan, S, Park, E-K, Park, S, Patel, J, Pati, S, Paudel, R, Paudel, U, Paun, M, Toroudi, HP, Peng, M, Pereira, J, Pereira, RB, Perna, S, Perumalsamy, N, Pestell, RG, Pezzani, R, Piccinelli, C, Pillay, JD, Piracha, ZZ, Pischon, T, Postma, MJ, Langroudi, AP, Pourshams, A, Pourtaheri, N, Prashant, A, Qadir, MMF, Syed, ZQ, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Raeisi, M, Rafiee, A, Rafiei, A, Raheem, N, Rahim, F, Rahman, MO, Rahman, M, Rahman, MA, Rahmani, AM, Rahmani, S, Rahmanian, V, Rajai, N, Rajesh, A, Ram, P, Ramezanzadeh, K, Rana, J, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rashedi, S, Rashidi, A, Rashidi, M-M, Ratan, ZA, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Razeghinia, MS, Rehman, AU, Rehman, IU, Reitsma, MB, Renzaho, AMN, Rezaei, M, Rezaei, N, Rezaei, S, Rezaeian, M, Rezapour, A, Riad, A, Rikhtegar, R, Rios-Blancas, M, Roberts, TJ, Rohloff, P, Romero-Rodriguez, E, Roshandel, G, Rwegerera, GM, Manjula, S, Saber-Ayad, MM, Saberzadeh-Ardestani, B, Sabour, S, Saddik, B, Sadeghi, E, Saeb, MR, Saeed, U, Safaei, M, Safary, A, Sahebazzamani, M, Sahebkar, A, Sahoo, H, Sajid, MR, Salari, H, Salehi, S, Salem, MR, Salimzadeh, H, Samodra, YL, Samy, AM, Sanabria, J, Sankararaman, S, Sanmarchi, F, Santric-Milicevic, MM, Saqib, MAN, Sarveazad, A, Sarvi, F, Sathian, B, Satpathy, M, Sayegh, N, Schneider, IJC, Schwarzinger, M, Sekerija, M, Senthilkumaran, S, Sepanlou, SG, Seylani, A, Seyoum, K, Sha, F, Shafaat, O, Shah, PA, Shahabi, S, Shahid, I, Shahrbaf, MA, Shahsavari, HR, Shaikh, MA, Shaka, MF, Shaker, E, Shannawaz, M, Sharew, MMS, Sharifi, A, Sharifi-Rad, J, Sharma, P, Shashamo, BB, Sheikh, A, Sheikh, M, Sheikhbahaei, S, Sheikhi, RA, Sheikhy, A, Shepherd, PR, Shetty, A, Shetty, JK, Shetty, RS, Shibuya, K, Shirkoohi, R, Shirzad-Aski, H, Shivakumar, KM, Shivalli, S, Shivarov, V, Shobeiri, P, Varniab, ZS, Shorofi, SA, Shrestha, S, Sibhat, MM, Malleshappa, SS, Sidemo, NB, Silva, DAS, Silva, LMLR, Julian, GS, Silvestris, N, Simegn, W, Singh, AD, Singh, A, Singh, G, Singh, H, Singh, JA, Singh, JK, Singh, P, Singh, S, Sinha, DN, Sinke, AH, Siraj, MS, Sitas, F, Siwal, SS, Skryabin, VY, Skryabina, AA, Socea, B, Soeberg, MJ, Sofi-Mahmudi, A, Solomon, Y, Soltani-Zangbar, MS, Song, S, Song, Y, Sorensen, RJD, Soshnikov, S, Sotoudeh, H, Sowe, A, Sufiyan, MB, Suk, R, Suleman, M, Abdulkader, RS, Sultana, S, Sur, D, Szacska, M, Tabaeian, SP, Tabares-Seisdedos, R, Tabatabaei, SM, Tabuchi, T, Tadbiri, H, Taheri, E, Taheri, M, Soodejani, MT, Takahashi, K, Talaat, IM, Tampa, M, Tan, K-K, Tat, NY, Tat, VY, Tavakoli, A, Tehrani-Banihashemi, A, Tekalegn, Y, Tesfay, FH, Thapar, R, Thavamani, A, Chandrasekar, VT, Thomas, N, Thomas, NK, Ticoalu, JHV, Tiyuri, A, Tollosa, DN, Topor-Madry, R, Touvier, M, Tovani-Palone, MR, Traini, E, Mai, TNT, Tripathy, JP, Ukke, GG, Ullah, I, Ullah, S, Unnikrishnan, B, Vacante, M, Vaezi, M, Tahbaz, SV, Valdez, PR, Vardavas, C, Varthya, SB, Vaziri, S, Velazquez, DZ, Veroux, M, Villeneuve, PJ, Violante, FS, Vladimirov, SK, Vlassov, V, Vo, B, Vu, LG, Wadood, AW, Waheed, Y, Walde, MT, Wamai, RG, Wang, C, Wang, F, Wang, N, Wang, Y, Ward, P, Waris, A, Westerman, R, Wickramasinghe, ND, Woldemariam, M, Woldu, B, Xiao, H, Xu, S, Xu, X, Yadav, L, Jabbari, SHY, Yang, L, Yazdanpanah, F, Yeshaw, Y, Yismaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yousefian, F, Yu, C, Yu, Y, Yunusa, I, Zahir, M, Zaki, N, Zaman, BA, Zangiabadian, M, Zare, F, Zare, I, Zareshahrabadi, Z, Zarrintan, A, Zastrozhin, MS, Zeineddine, MA, Zhang, D, Zhang, J, Zhang, Y, Zhang, Z-J, Zhou, L, Zodpey, S, Zoladl, M, Vos, T, Hay, S, Force, LM, and Murray, CJL
Abstract: BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [2
Published: 2022

3. The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Alvarez, EM, Force, LM, Xu, R, Compton, K, Lu, D, Henrikson, HJ, Kocarnik, JM, Harvey, JD, Pennini, A, Dean, FE, Fu, W, Vargas, MT, Keegan, THM, Ariffin, H, Barr, RD, Erdomaeva, YA, Gunasekera, DS, John-Akinola, YO, Ketterl, TG, Kutluk, T, Malogolowkin, MH, Mathur, P, Radhakrishnan, V, Ries, LAG, Rodriguez-Galindo, C, Sagoyan, GB, Sultan, I, Abbasi, B, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdelmasseh, M, Abd-Elsalam, S, Abdoli, A, Abebe, H, Abedi, A, Abidi, H, Abolhassani, H, Ali, HA, Abu-Gharbieh, E, Achappa, B, Acuna, JM, Adedeji, IA, Adegboye, OA, Adnani, QES, Advani, SM, Afzal, MS, Meybodi, MA, Ahadinezhad, B, Ahinkorah, BO, Ahmad, S, Ahmadi, S, Ahmed, MB, Rashid, TA, Salih, YA, Aiman, W, Akalu, GT, Al Hamad, H, Alahdab, F, AlAmodi, AA, Alanezi, FM, Alanzi, TM, Alem, AZ, Alem, DT, Alemayehu, Y, Alhalaiqa, FN, Alhassan, RK, Ali, S, Alicandro, G, Alipour, V, Aljunid, SM, Alkhayyat, M, Alluri, S, Almasri, NA, Al-Maweri, SA, Almustanyir, S, Al-Raddadi, RM, Alvis-Guzman, N, Ameyaw, EK, Amini, S, Amu, H, Ancuceanu, R, Andrei, CL, Andrei, T, Ansari, F, Ansari-Moghaddam, A, Anvari, D, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Argaw, AM, Arshad, M, Arulappan, J, Aryannejad, A, Asemi, Z, Jafarabadi, MA, Atashzar, MR, Atorkey, P, Atreya, A, Attia, S, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awedew, AF, Quintanilla, BPA, Ayele, AD, Ayen, SS, Azab, MA, Azadnajafabad, S, Azami, H, Azangou-Khyavy, M, Jafari, AA, Azarian, G, Azzam, AY, Bahadory, S, Bai, J, Baig, AA, Baker, JL, Banach, M, Barnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Basaleem, H, Batiha, A-MM, Behzadifar, M, Bekele, NC, Belete, R, Belgaumi, UI, Bell, AW, Berhie, AY, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Birara, S, Bjorge, T, Bolarinwa, OA, Bolla, SR, Boloor, A, Braithwaite, D, Brenner, H, Bulamu, NB, Burkart, K, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, dos Santos, FLC, Cao, C, Cao, Y, Carreras, G, Catala-Lopez, F, Cembranel, F, Cerin, E, Chakinala, RC, Chakraborty, PA, Chattu, VK, Chaturvedi, P, Chaurasia, A, Chavan, PP, Chimed-Ochir, O, Choi, J-YJ, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Costa, VM, Daar, OB, Dadras, O, Dahlawi, SMA, Dai, X, Damiani, G, Amico, ED, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darwish, AH, Daryani, A, De la Hoz, FP, Debela, SA, Demie, TGG, Demissie, GD, Demissie, ZG, Denova-Gutierrez, E, Molla, MD, Desai, R, Desta, AA, Dhamnetiya, D, Dharmaratne, SD, Dhimal, ML, Dhimal, M, Dianatinasab, M, Didehdar, M, Diress, M, Djalalinia, S, Huyen, PD, Doaei, S, Dorostkar, F, dos Santos, WM, Drake, TM, Ekholuenetale, M, El Sayed, I, Zaki, MES, El Tantawi, M, El-Abid, H, Elbahnasawy, MA, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, S, Enyew, DB, Erkhembayar, R, Eshrati, B, Eskandarieh, S, Faisaluddin, M, Fares, J, Farooque, U, Fasanmi, AO, Fatima, W, Ferreira de Oliveira, JMP, Ferrero, S, Desideri, LF, Fetensa, G, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gaewkhiew, P, Gallus, S, Garg, T, Gemeda, BNB, Getachew, T, Ghafourifard, M, Ghamari, S-H, Ghashghaee, A, Ghassemi, F, Ghith, N, Gholami, A, Navashenaq, JG, Gilani, SA, Ginindza, TG, Gizaw, AT, Glasbey, JC, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gopalani, SV, Gorini, G, Goudarzi, H, Goulart, BNG, Grada, A, Gubari, MIM, Guerra, MR, Guha, A, Gupta, B, Gupta, S, Gupta, VB, Gupta, VK, Haddadi, R, Hafezi-Nejad, N, Hailu, A, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hambisa, MT, Hameed, S, Hamidi, S, Haque, S, Hariri, S, Haro, JM, Hasaballah, A, Hasan, SMM, Hashemi, SM, Hassan, TS, Hassanipour, S, Hay, S, Hayat, K, Hebo, SH, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Heyi, DZ, Hezam, K, Hole, MK, Holla, R, Horita, N, Hossain, MM, Hossain, MB, Hosseini, M-S, Hosseini, M, Hosseinzadeh, A, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hussein, NR, Hwang, B-F, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Innos, K, Irham, LM, Islam, RM, Islam, SMS, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jadidi-Niaragh, F, Jain, V, Jakovljevic, M, Janghorban, R, Mamaghani, AJ, Jayaram, S, Jayawardena, R, Jazayeri, SB, Jebai, R, Jha, RP, Joo, T, Joseph, N, Joukar, F, Jurisson, M, Kaambwa, B, Kabir, A, Kalankesh, LR, Kaliyadan, F, Kamal, Z, Kamath, A, Kandel, H, Kar, SS, Karaye, IM, Karimi, A, Kassa, BG, Kauppila, JH, Bohan, PMK, Kengne, AP, Kerbo, AA, Keykhaei, M, Khader, YS, Khajuria, H, Khalili, N, Khan, EA, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khanali, J, Khayamzadeh, M, Khosravizadeh, O, Khubchandani, J, Khundkar, R, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kolahi, A-A, Kopec, JA, Koteeswaran, R, Laxminarayana, SLK, Koyanagi, A, Kugbey, N, Kumar, GA, Kumar, N, Kwarteng, A, La Vecchia, C, Lan, Q, Landires, I, Lasrado, S, Lauriola, P, Ledda, C, Lee, S-W, Lee, W-C, Lee, YY, Lee, YH, Leigh, J, Leong, E, Li, B, Li, J, Li, M-C, Lim, SS, Liu, X, Lobo, SW, Loureiro, JA, Lugo, A, Lunevicius, R, Abd El Razek, HM, Razek, MMAE, Mahmoudi, M, Majeed, A, Makki, A, Male, S, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mamun, MA, Manafi, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, MA, Martini, S, Masoumi, SZ, Matei, CN, Mathur, MR, McAlinden, C, Mehrotra, R, Mendoza, W, Menezes, RG, Mentis, A-FA, Meretoja, TJ, Mersha, AG, Mesregah, MK, Mestrovic, T, Jonasson, JM, Miazgowski, B, Michalek, IM, Miller, TR, Mingude, AB, Mirmoeeni, S, Mirzaei, H, Misra, S, Mithra, P, Mohammad, KA, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, A, Mohammed, S, Mohammed, TA, Moka, N, Mokdad, AH, Molokhia, M, Momtazmanesh, S, Monasta, L, Moni, MA, Moradi, G, Moradi, Y, Moradzadeh, M, Moradzadeh, R, Moraga, P, Morrison, SD, Mostafavi, E, Khaneghah, AM, Mpundu-Kaambwa, C, Mubarik, S, Mwanri, L, Nabhan, AF, Nagaraju, SP, Nagata, C, Naghavi, M, Naimzada, MD, Naldi, L, Nangia, V, Naqvi, AA, Swamy, SN, Narayana, AI, Nayak, BP, Nayak, VC, Nazari, J, Nduaguba, SO, Negoi, I, Negru, SM, Nejadghaderi, SA, Nepal, S, Kandel, SN, Nggada, HA, Nguyen, CT, Nnaji, CA, Nosrati, H, Nouraei, H, Nowroozi, A, Nunez-Samudio, V, Nwatah, VE, Nzoputam, CI, Oancea, B, Odukoya, OO, Oguntade, AS, Oh, I-H, Olagunju, AT, Olagunju, TO, Olakunde, BO, Oluwasanu, MM, Omar, E, Bali, AO, Ong, S, Onwujekwe, OE, Ortega-Altamirano, D, Otstavnov, N, Otstavnov, SS, Oumer, B, Owolabi, MO, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Pakshir, K, Pana, A, Pandey, A, Pardhan, S, Kan, FP, Pasovic, M, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, RB, Peres, MFP, Perianayagam, A, Postma, MJ, Pourjafar, H, Pourshams, A, Prashant, A, Pulakunta, T, Qadir, MMFF, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Rafiee, A, Rafiei, A, Rafiei, S, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Rahmani, AM, Rajesh, A, Ramezani-Doroh, V, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rashedi, S, Rashidi, M-M, Rath, GK, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Razeghinia, MS, Regasa, MT, Renzaho, AMN, Rezaei, M, Rezaei, N, Rezaeian, M, Rezapour, A, Rezazadeh-Khadem, S, Riad, A, Lopez, LER, Rodriguez, JAB, Ronfani, L, Roshandel, G, Rwegerera, GM, Saber-Ayad, MM, Sabour, S, Saddik, B, Sadeghi, E, Sadeghian, S, Saeed, U, Sahebkar, A, Saif-Ur-Rahman, KM, Sajadi, SM, Salahi, S, Salehi, S, Salem, MR, Salimzadeh, H, Samy, AM, Sanabria, J, Sanmarchi, F, Sarveazad, A, Sathian, B, Sawhney, M, Sawyer, SM, Saylan, M, Schneider, IJC, Seidu, A-A, Sekerija, M, Sendo, EG, Sepanlou, SG, Seylani, A, Seyoum, K, Sha, F, Shafaat, O, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Sharma, R, Sheikhbahaei, S, Shetty, A, Shetty, BSK, Shetty, PH, Shin, JI, Shirkoohi, R, Shivakumar, KM, Shobeiri, P, Siabani, S, Sibhat, MM, Malleshappa, SKS, Sidemo, NB, Silva, DAS, Julian, GS, Singh, AD, Singh, JA, Singh, JK, Singh, S, Sinke, AH, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Smith, L, Sofi-Mahmudi, A, Soltani-Zangbar, MS, Song, S, Spurlock, EE, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Abdulkader, RS, Sultana, S, Szerencses, V, Szocska, M, Tabaeian, SP, Tabaras-Seisdedos, R, Tabary, M, Tabuchi, T, Tadbiri, H, Taheri, M, Taherkhani, A, Takahashi, K, Tampa, M, Tan, K-K, Tat, VY, Tavakoli, A, Tbakhi, A, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tesfaye, B, Thakur, JS, Thapar, R, Thavamani, A, Thiyagarajan, A, Thomas, N, Tobe-Gai, R, Togtmol, M, Tohidast, SA, Tohidinik, HR, Tolani, MA, Tollosa, DN, Touvier, M, Tovani-Palone, MR, Traini, E, Bach, XT, Mai, TNT, Tripathy, JP, Tusa, BS, Ukke, GG, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Upadhyay, E, Ushula, TW, Vacante, M, Tahbaz, SV, Varthya, SB, Veroux, M, Villeneuve, PJ, Violante, FS, Vlassov, V, Giang, TV, Waheed, Y, Wang, N, Ward, P, Weldesenbet, AB, Wen, YF, Westerman, R, Winkler, AS, Wubishet, BL, Xu, S, Jabbari, SHY, Yang, L, Yaya, S, Yazdi-Feyzabadi, V, Yazie, TS, Yehualashet, SS, Yeshaneh, A, Yeshaw, Y, Yirdaw, BW, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yunusa, I, Zadnik, V, Zahir, M, Moghadam, TZ, Zamani, M, Zamanian, M, Zandian, H, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhang, Z-J, Ziapour, A, Zoladl, M, Murray, CJL, Fitzmaurice, C, Bleyer, A, Bhakta, N, Gebremeskel, TG, Alvarez, EM, Force, LM, Xu, R, Compton, K, Lu, D, Henrikson, HJ, Kocarnik, JM, Harvey, JD, Pennini, A, Dean, FE, Fu, W, Vargas, MT, Keegan, THM, Ariffin, H, Barr, RD, Erdomaeva, YA, Gunasekera, DS, John-Akinola, YO, Ketterl, TG, Kutluk, T, Malogolowkin, MH, Mathur, P, Radhakrishnan, V, Ries, LAG, Rodriguez-Galindo, C, Sagoyan, GB, Sultan, I, Abbasi, B, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdelmasseh, M, Abd-Elsalam, S, Abdoli, A, Abebe, H, Abedi, A, Abidi, H, Abolhassani, H, Ali, HA, Abu-Gharbieh, E, Achappa, B, Acuna, JM, Adedeji, IA, Adegboye, OA, Adnani, QES, Advani, SM, Afzal, MS, Meybodi, MA, Ahadinezhad, B, Ahinkorah, BO, Ahmad, S, Ahmadi, S, Ahmed, MB, Rashid, TA, Salih, YA, Aiman, W, Akalu, GT, Al Hamad, H, Alahdab, F, AlAmodi, AA, Alanezi, FM, Alanzi, TM, Alem, AZ, Alem, DT, Alemayehu, Y, Alhalaiqa, FN, Alhassan, RK, Ali, S, Alicandro, G, Alipour, V, Aljunid, SM, Alkhayyat, M, Alluri, S, Almasri, NA, Al-Maweri, SA, Almustanyir, S, Al-Raddadi, RM, Alvis-Guzman, N, Ameyaw, EK, Amini, S, Amu, H, Ancuceanu, R, Andrei, CL, Andrei, T, Ansari, F, Ansari-Moghaddam, A, Anvari, D, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Argaw, AM, Arshad, M, Arulappan, J, Aryannejad, A, Asemi, Z, Jafarabadi, MA, Atashzar, MR, Atorkey, P, Atreya, A, Attia, S, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awedew, AF, Quintanilla, BPA, Ayele, AD, Ayen, SS, Azab, MA, Azadnajafabad, S, Azami, H, Azangou-Khyavy, M, Jafari, AA, Azarian, G, Azzam, AY, Bahadory, S, Bai, J, Baig, AA, Baker, JL, Banach, M, Barnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Basaleem, H, Batiha, A-MM, Behzadifar, M, Bekele, NC, Belete, R, Belgaumi, UI, Bell, AW, Berhie, AY, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Birara, S, Bjorge, T, Bolarinwa, OA, Bolla, SR, Boloor, A, Braithwaite, D, Brenner, H, Bulamu, NB, Burkart, K, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, dos Santos, FLC, Cao, C, Cao, Y, Carreras, G, Catala-Lopez, F, Cembranel, F, Cerin, E, Chakinala, RC, Chakraborty, PA, Chattu, VK, Chaturvedi, P, Chaurasia, A, Chavan, PP, Chimed-Ochir, O, Choi, J-YJ, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Costa, VM, Daar, OB, Dadras, O, Dahlawi, SMA, Dai, X, Damiani, G, Amico, ED, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darwish, AH, Daryani, A, De la Hoz, FP, Debela, SA, Demie, TGG, Demissie, GD, Demissie, ZG, Denova-Gutierrez, E, Molla, MD, Desai, R, Desta, AA, Dhamnetiya, D, Dharmaratne, SD, Dhimal, ML, Dhimal, M, Dianatinasab, M, Didehdar, M, Diress, M, Djalalinia, S, Huyen, PD, Doaei, S, Dorostkar, F, dos Santos, WM, Drake, TM, Ekholuenetale, M, El Sayed, I, Zaki, MES, El Tantawi, M, El-Abid, H, Elbahnasawy, MA, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, S, Enyew, DB, Erkhembayar, R, Eshrati, B, Eskandarieh, S, Faisaluddin, M, Fares, J, Farooque, U, Fasanmi, AO, Fatima, W, Ferreira de Oliveira, JMP, Ferrero, S, Desideri, LF, Fetensa, G, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gaewkhiew, P, Gallus, S, Garg, T, Gemeda, BNB, Getachew, T, Ghafourifard, M, Ghamari, S-H, Ghashghaee, A, Ghassemi, F, Ghith, N, Gholami, A, Navashenaq, JG, Gilani, SA, Ginindza, TG, Gizaw, AT, Glasbey, JC, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gopalani, SV, Gorini, G, Goudarzi, H, Goulart, BNG, Grada, A, Gubari, MIM, Guerra, MR, Guha, A, Gupta, B, Gupta, S, Gupta, VB, Gupta, VK, Haddadi, R, Hafezi-Nejad, N, Hailu, A, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hambisa, MT, Hameed, S, Hamidi, S, Haque, S, Hariri, S, Haro, JM, Hasaballah, A, Hasan, SMM, Hashemi, SM, Hassan, TS, Hassanipour, S, Hay, S, Hayat, K, Hebo, SH, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Heyi, DZ, Hezam, K, Hole, MK, Holla, R, Horita, N, Hossain, MM, Hossain, MB, Hosseini, M-S, Hosseini, M, Hosseinzadeh, A, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hussein, NR, Hwang, B-F, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Innos, K, Irham, LM, Islam, RM, Islam, SMS, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jadidi-Niaragh, F, Jain, V, Jakovljevic, M, Janghorban, R, Mamaghani, AJ, Jayaram, S, Jayawardena, R, Jazayeri, SB, Jebai, R, Jha, RP, Joo, T, Joseph, N, Joukar, F, Jurisson, M, Kaambwa, B, Kabir, A, Kalankesh, LR, Kaliyadan, F, Kamal, Z, Kamath, A, Kandel, H, Kar, SS, Karaye, IM, Karimi, A, Kassa, BG, Kauppila, JH, Bohan, PMK, Kengne, AP, Kerbo, AA, Keykhaei, M, Khader, YS, Khajuria, H, Khalili, N, Khan, EA, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khanali, J, Khayamzadeh, M, Khosravizadeh, O, Khubchandani, J, Khundkar, R, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kolahi, A-A, Kopec, JA, Koteeswaran, R, Laxminarayana, SLK, Koyanagi, A, Kugbey, N, Kumar, GA, Kumar, N, Kwarteng, A, La Vecchia, C, Lan, Q, Landires, I, Lasrado, S, Lauriola, P, Ledda, C, Lee, S-W, Lee, W-C, Lee, YY, Lee, YH, Leigh, J, Leong, E, Li, B, Li, J, Li, M-C, Lim, SS, Liu, X, Lobo, SW, Loureiro, JA, Lugo, A, Lunevicius, R, Abd El Razek, HM, Razek, MMAE, Mahmoudi, M, Majeed, A, Makki, A, Male, S, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mamun, MA, Manafi, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, MA, Martini, S, Masoumi, SZ, Matei, CN, Mathur, MR, McAlinden, C, Mehrotra, R, Mendoza, W, Menezes, RG, Mentis, A-FA, Meretoja, TJ, Mersha, AG, Mesregah, MK, Mestrovic, T, Jonasson, JM, Miazgowski, B, Michalek, IM, Miller, TR, Mingude, AB, Mirmoeeni, S, Mirzaei, H, Misra, S, Mithra, P, Mohammad, KA, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, A, Mohammed, S, Mohammed, TA, Moka, N, Mokdad, AH, Molokhia, M, Momtazmanesh, S, Monasta, L, Moni, MA, Moradi, G, Moradi, Y, Moradzadeh, M, Moradzadeh, R, Moraga, P, Morrison, SD, Mostafavi, E, Khaneghah, AM, Mpundu-Kaambwa, C, Mubarik, S, Mwanri, L, Nabhan, AF, Nagaraju, SP, Nagata, C, Naghavi, M, Naimzada, MD, Naldi, L, Nangia, V, Naqvi, AA, Swamy, SN, Narayana, AI, Nayak, BP, Nayak, VC, Nazari, J, Nduaguba, SO, Negoi, I, Negru, SM, Nejadghaderi, SA, Nepal, S, Kandel, SN, Nggada, HA, Nguyen, CT, Nnaji, CA, Nosrati, H, Nouraei, H, Nowroozi, A, Nunez-Samudio, V, Nwatah, VE, Nzoputam, CI, Oancea, B, Odukoya, OO, Oguntade, AS, Oh, I-H, Olagunju, AT, Olagunju, TO, Olakunde, BO, Oluwasanu, MM, Omar, E, Bali, AO, Ong, S, Onwujekwe, OE, Ortega-Altamirano, D, Otstavnov, N, Otstavnov, SS, Oumer, B, Owolabi, MO, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Pakshir, K, Pana, A, Pandey, A, Pardhan, S, Kan, FP, Pasovic, M, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, RB, Peres, MFP, Perianayagam, A, Postma, MJ, Pourjafar, H, Pourshams, A, Prashant, A, Pulakunta, T, Qadir, MMFF, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Rafiee, A, Rafiei, A, Rafiei, S, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Rahmani, AM, Rajesh, A, Ramezani-Doroh, V, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rashedi, S, Rashidi, M-M, Rath, GK, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Razeghinia, MS, Regasa, MT, Renzaho, AMN, Rezaei, M, Rezaei, N, Rezaeian, M, Rezapour, A, Rezazadeh-Khadem, S, Riad, A, Lopez, LER, Rodriguez, JAB, Ronfani, L, Roshandel, G, Rwegerera, GM, Saber-Ayad, MM, Sabour, S, Saddik, B, Sadeghi, E, Sadeghian, S, Saeed, U, Sahebkar, A, Saif-Ur-Rahman, KM, Sajadi, SM, Salahi, S, Salehi, S, Salem, MR, Salimzadeh, H, Samy, AM, Sanabria, J, Sanmarchi, F, Sarveazad, A, Sathian, B, Sawhney, M, Sawyer, SM, Saylan, M, Schneider, IJC, Seidu, A-A, Sekerija, M, Sendo, EG, Sepanlou, SG, Seylani, A, Seyoum, K, Sha, F, Shafaat, O, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Sharma, R, Sheikhbahaei, S, Shetty, A, Shetty, BSK, Shetty, PH, Shin, JI, Shirkoohi, R, Shivakumar, KM, Shobeiri, P, Siabani, S, Sibhat, MM, Malleshappa, SKS, Sidemo, NB, Silva, DAS, Julian, GS, Singh, AD, Singh, JA, Singh, JK, Singh, S, Sinke, AH, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Smith, L, Sofi-Mahmudi, A, Soltani-Zangbar, MS, Song, S, Spurlock, EE, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Abdulkader, RS, Sultana, S, Szerencses, V, Szocska, M, Tabaeian, SP, Tabaras-Seisdedos, R, Tabary, M, Tabuchi, T, Tadbiri, H, Taheri, M, Taherkhani, A, Takahashi, K, Tampa, M, Tan, K-K, Tat, VY, Tavakoli, A, Tbakhi, A, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tesfaye, B, Thakur, JS, Thapar, R, Thavamani, A, Thiyagarajan, A, Thomas, N, Tobe-Gai, R, Togtmol, M, Tohidast, SA, Tohidinik, HR, Tolani, MA, Tollosa, DN, Touvier, M, Tovani-Palone, MR, Traini, E, Bach, XT, Mai, TNT, Tripathy, JP, Tusa, BS, Ukke, GG, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Upadhyay, E, Ushula, TW, Vacante, M, Tahbaz, SV, Varthya, SB, Veroux, M, Villeneuve, PJ, Violante, FS, Vlassov, V, Giang, TV, Waheed, Y, Wang, N, Ward, P, Weldesenbet, AB, Wen, YF, Westerman, R, Winkler, AS, Wubishet, BL, Xu, S, Jabbari, SHY, Yang, L, Yaya, S, Yazdi-Feyzabadi, V, Yazie, TS, Yehualashet, SS, Yeshaneh, A, Yeshaw, Y, Yirdaw, BW, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yunusa, I, Zadnik, V, Zahir, M, Moghadam, TZ, Zamani, M, Zamanian, M, Zandian, H, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhang, Z-J, Ziapour, A, Zoladl, M, Murray, CJL, Fitzmaurice, C, Bleyer, A, Bhakta, N, and Gebremeskel, TG
Abstract: BACKGROUND: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. METHODS: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. FINDINGS: There were 1·19 million (95% UI 1·11-1·28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5-65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8-57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14
Published: 2022

4. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

Author: Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Ababneh, E, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Abbasi-Kangevari, M, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Abbastabar, H, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Abd-Elsalam, SM, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Abdoli, A, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Abedi, A, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Abidi, H, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Abolhassani, H, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Adedeji, IA, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Adnani, QES, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Advani, SM, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Afzal, MS, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Aghaali, M, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Ahinkorah, BO, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ahmad, S, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, SMS, Ahmad, T, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Ahmadi, A, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Ahmadi, S, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Ahmed Rashid, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Ahmed Salih, Y, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Akalu, GT, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Aklilu, A, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Akram, T, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Akunna, CJ, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Al Hamad, H, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Alahdab, F, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Al-Aly, Z, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Ali, S, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, Nduaguba, SO, Negoi, I, Negru, SM, Alimohamadi, Y, Neupane Kandel, S, Nguyen, CT, Nguyen, HLT, Niazi, RK, Nnaji, CA, Noor, NM, Nuñez-Samudio, V, Nzoputam, CI, Oancea, B, Ochir, C, Alipour, V, Odukoya, OO, Ogbo, FA, Olagunju, AT, Olakunde, BO, Omar, E, Omar Bali, A, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Aljunid, SM, Ortega-Altamirano, DV, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P A, M, Padubidri, JR, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Alkhayyat, M, Pardhan, S, Park, E-C, Park, E-K, Pashazadeh Kan, F, Patel, HK, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, DM, Almasi-Hashiani, A, Pereira, RB, Perianayagam, A, Pillay, JD, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, MJ, Pourjafar, H, Prashant, A, Preotescu, L, Almasri, NA, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Al-Maweri, SAA, Rahmani, AM, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Almustanyir, S, Rawassizadeh, R, Razeghinia, MS, Renzaho, AMN, Rezaei, N, Rezapour, A, Roberts, TJ, Rodriguez, JAB, Rohloff, P, Romoli, M, Alonso, N, Ronfani, L, Roshandel, G, Rwegerera, GM, S, M, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Alvis-Guzman, N, Salem, MR, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sankararaman, S, Santric-Milicevic, MM, Sardiwalla, Y, Sarveazad, A, Sathian, B, Amu, H, Sawhney, M, Saylan, M, Schneider, IJC, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Anbesu, EW, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, JK, Shetty, PH, Shibuya, K, Shirkoohi, R, Shivakumar, KM, Shivarov, V, Ancuceanu, R, Siabani, S, Siddappa Malleshappa, SK, Silva, DAS, Singh, JA, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Ansari, F, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Ansari-Moghaddam, A, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Antwi, MH, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Anvari, D, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Anyasodor, AE, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Aqeel, M, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Arabloo, J, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Arab-Zozani, M, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Aremu, O, Murray, CJL, Force, LM, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Ababneh, E, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Abbasi-Kangevari, M, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Abbastabar, H, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Abd-Elsalam, SM, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Abdoli, A, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Abedi, A, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Abidi, H, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Abolhassani, H, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Adedeji, IA, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Adnani, QES, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Advani, SM, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Afzal, MS, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Aghaali, M, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Ahinkorah, BO, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ahmad, S, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, SMS, Ahmad, T, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Ahmadi, A, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Ahmadi, S, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Ahmed Rashid, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Ahmed Salih, Y, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Akalu, GT, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Aklilu, A, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Akram, T, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Akunna, CJ, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Al Hamad, H, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Alahdab, F, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Al-Aly, Z, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Ali, S, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, Nduaguba, SO, Negoi, I, Negru, SM, Alimohamadi, Y, Neupane Kandel, S, Nguyen, CT, Nguyen, HLT, Niazi, RK, Nnaji, CA, Noor, NM, Nuñez-Samudio, V, Nzoputam, CI, Oancea, B, Ochir, C, Alipour, V, Odukoya, OO, Ogbo, FA, Olagunju, AT, Olakunde, BO, Omar, E, Omar Bali, A, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Aljunid, SM, Ortega-Altamirano, DV, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P A, M, Padubidri, JR, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Alkhayyat, M, Pardhan, S, Park, E-C, Park, E-K, Pashazadeh Kan, F, Patel, HK, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, DM, Almasi-Hashiani, A, Pereira, RB, Perianayagam, A, Pillay, JD, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, MJ, Pourjafar, H, Prashant, A, Preotescu, L, Almasri, NA, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Al-Maweri, SAA, Rahmani, AM, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Almustanyir, S, Rawassizadeh, R, Razeghinia, MS, Renzaho, AMN, Rezaei, N, Rezapour, A, Roberts, TJ, Rodriguez, JAB, Rohloff, P, Romoli, M, Alonso, N, Ronfani, L, Roshandel, G, Rwegerera, GM, S, M, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Alvis-Guzman, N, Salem, MR, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sankararaman, S, Santric-Milicevic, MM, Sardiwalla, Y, Sarveazad, A, Sathian, B, Amu, H, Sawhney, M, Saylan, M, Schneider, IJC, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Anbesu, EW, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, JK, Shetty, PH, Shibuya, K, Shirkoohi, R, Shivakumar, KM, Shivarov, V, Ancuceanu, R, Siabani, S, Siddappa Malleshappa, SK, Silva, DAS, Singh, JA, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Ansari, F, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Ansari-Moghaddam, A, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Antwi, MH, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Anvari, D, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Anyasodor, AE, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Aqeel, M, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Arabloo, J, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Arab-Zozani, M, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Aremu, O, Murray, CJL, Force, LM, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, and Bhattacharyya, K
Abstract: Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low
Published: 2022

5. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019:A Systematic Analysis for the Global Burden of Disease Study 2019

Author: Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Ababneh, E, Abbasi-Kangevari, M, Abbastabar, H, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abidi, H, Abolhassani, H, Adedeji, IA, Adnani, QES, Advani, SM, Afzal, MS, Aghaali, M, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, A, Ahmadi, S, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, GT, Aklilu, A, Akram, T, Akunna, CJ, Al Hamad, H, Alahdab, F, Al-Aly, Z, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Almasi-Hashiani, A, Almasri, NA, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alvis-Guzman, N, Amu, H, Anbesu, EW, Ancuceanu, R, Ansari, F, Ansari-Moghaddam, A, Antwi, MH, Anvari, D, Anyasodor, AE, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aremu, O, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, Das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, SMS, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, Nduaguba, SO, Negoi, I, Negru, SM, Neupane Kandel, S, Nguyen, CT, Nguyen, HLT, Niazi, RK, Nnaji, CA, Noor, NM, Nuñez-Samudio, V, Nzoputam, CI, Oancea, B, Ochir, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Olakunde, BO, Omar, E, Omar Bali, A, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Ortega-Altamirano, DV, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P A, M, Padubidri, JR, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Pardhan, S, Park, E-C, Park, E-K, Pashazadeh Kan, F, Patel, HK, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, DM, Pereira, RB, Perianayagam, A, Pillay, JD, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, MJ, Pourjafar, H, Prashant, A, Preotescu, L, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Rahmani, AM, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rawassizadeh, R, Razeghinia, MS, Renzaho, AMN, Rezaei, N, Rezapour, A, Roberts, TJ, Rodriguez, JAB, Rohloff, P, Romoli, M, Ronfani, L, Roshandel, G, Rwegerera, GM, S, M, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Salem, MR, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sankararaman, S, Santric-Milicevic, MM, Sardiwalla, Y, Sarveazad, A, Sathian, B, Sawhney, M, Saylan, M, Schneider, IJC, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, JK, Shetty, PH, Shibuya, K, Shirkoohi, R, Shivakumar, KM, Shivarov, V, Siabani, S, Siddappa Malleshappa, SK, Silva, DAS, Singh, JA, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Murray, CJL, Force, LM, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Kocarnik, J, Compton, K, Dean, F, Fu, W, Gaw, B, Harvey, J, Henrikson, H, Lu, D, Pennini, A, Xu, R, Ababneh, E, Abbasi-Kangevari, M, Abbastabar, H, Abd-Elsalam, S, Abdoli, A, Abedi, A, Abidi, H, Abolhassani, H, Adedeji, I, Adnani, Q, Advani, S, Afzal, M, Aghaali, M, Ahinkorah, B, Ahmad, S, Ahmad, T, Ahmadi, A, Ahmadi, S, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, G, Aklilu, A, Akram, T, Akunna, C, Al Hamad, H, Alahdab, F, Al-Aly, Z, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, S, Alkhayyat, M, Almasi-Hashiani, A, Almasri, N, Al-Maweri, S, Almustanyir, S, Alonso, N, Alvis-Guzman, N, Amu, H, Anbesu, E, Ancuceanu, R, Ansari, F, Ansari-Moghaddam, A, Antwi, M, Anvari, D, Anyasodor, A, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aremu, O, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, A, Ayala Quintanilla, B, Ayenew, T, Azab, M, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, A, Badiye, A, Bahadory, S, Baig, A, Baker, J, Balakrishnan, S, Banach, M, Barnighausen, T, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, U, Bezabhe, W, Bezabih, Y, Bhagat, D, Bhagavathula, A, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, V, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjorge, T, Bleyer, A, Blyuss, O, Bolarinwa, O, Bolla, S, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, M, Butt, N, Butt, Z, Caetano Dos Santos, F, Cao, Y, Carreras, G, Catala-Lopez, F, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, R, Chattu, S, Chattu, V, Chaturvedi, P, Chimed-Ochir, O, Cho, D, Christopher, D, Chu, D, Chung, M, Conde, J, Cortes, S, Cortesi, P, Costa, V, Cunha, A, Dadras, O, Dagnew, A, Dahlawi, S, Dai, X, Dandona, L, Dandona, R, Darwesh, A, Das Neves, J, De La Hoz, F, Demis, A, Denova-Gutierrez, E, Dhamnetiya, D, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, H, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, F, Driscoll, T, Ebrahimi, H, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, H, Elhadi, M, El-Jaafary, S, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, E, Fares, J, Farzadfar, F, Feroze, A, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Fisher, J, Foroutan, M, Fukumoto, T, Gaal, P, Gad, M, Gadanya, M, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, S, Ginindza, T, Gizaw, A, Glasbey, J, Golechha, M, Goleij, P, Gomez, R, Gopalani, S, Gorini, G, Goudarzi, H, Grosso, G, Gubari, M, Guerra, M, Guha, A, Gunasekera, D, Gupta, B, Gupta, V, Gutierrez, R, Hafezi-Nejad, N, Haider, M, Haj-Mirzaian, A, Halwani, R, Hamadeh, R, Hameed, S, Hamidi, S, Hanif, A, Haque, S, Harlianto, N, Haro, J, Hasaballah, A, Hassanipour, S, Hay, R, Hay, S, Hayat, K, Heidari, G, Heidari, M, Herrera-Serna, B, Herteliu, C, Hezam, K, Holla, R, Hossain, M, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, F, Hussain, R, Hussein, N, Hwang, B, Iavicoli, I, Ibitoye, S, Ida, F, Ikuta, K, Ilesanmi, O, Ilic, I, Ilic, M, Irham, L, Islam, J, Islam, R, Islam, S, Ismail, N, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, M, Javaheri, T, Jayaram, S, Jazayeri, S, Jha, R, Jonas, J, Joo, T, Joseph, N, Joukar, F, Jurisson, M, Kabir, A, Kahrizi, D, Kalankesh, L, Kalhor, R, Kaliyadan, F, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, A, Katikireddi, S, Kauppila, J, Kavetskyy, T, Kebede, S, Keshavarz, P, Keykhaei, M, Khader, Y, Khalilov, R, Khan, G, Khan, M, Khang, Y, Khater, A, Khayamzadeh, M, Kim, G, Kim, Y, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, J, Koteeswaran, R, Koul, P, Koulmane Laxminarayana, S, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, G, Kumar, N, Kurmi, O, Kutluk, T, La Vecchia, C, Lami, F, Landires, I, Lauriola, P, Lee, S, Lee, W, Lee, Y, Leigh, J, Leong, E, Li, J, Li, M, Liu, X, Loureiro, J, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, A, Mansournia, M, Martini, S, Masoumi, S, Mathur, P, Mckee, M, Mehrotra, R, Mendoza, W, Menezes, R, Mengesha, E, Mesregah, M, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, I, Miller, T, Mirzaei, H, Misra, S, Mithra, P, Moghadaszadeh, M, Mohammad, K, Mohammad, Y, Mohammadi, M, Mohammadi, S, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, A, Molokhia, M, Monasta, L, Moni, M, Moosavi, M, Moradi, Y, Moraga, P, Morgado-Da-Costa, J, Morrison, S, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, A, Nagaraju, S, Nagata, C, Naimzada, M, Nangia, V, Naqvi, A, Narasimha Swamy, S, Ndejjo, R, Nduaguba, S, Negoi, I, Negru, S, Neupane Kandel, S, Nguyen, C, Nguyen, H, Niazi, R, Nnaji, C, Noor, N, Nunez-Samudio, V, Nzoputam, C, Oancea, B, Ochir, C, Odukoya, O, Ogbo, F, Olagunju, A, Olakunde, B, Omar, E, Omar Bali, A, Omonisi, A, Ong, S, Onwujekwe, O, Orru, H, Ortega-Altamirano, D, Otstavnov, N, Otstavnov, S, Owolabi, M, P A, M, Padubidri, J, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Pardhan, S, Park, E, Pashazadeh Kan, F, Patel, H, Patel, J, Pati, S, Pattanshetty, S, Paudel, U, Pereira, D, Pereira, R, Perianayagam, A, Pillay, J, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, M, Pourjafar, H, Prashant, A, Preotescu, L, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, R, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahmani, A, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, C, Rao, S, Rawassizadeh, R, Razeghinia, M, Renzaho, A, Rezaei, N, Rezapour, A, Roberts, T, Rodriguez, J, Rohloff, P, Romoli, M, Ronfani, L, Roshandel, G, Rwegerera, G, Manjula, S, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Salem, M, Salimzadeh, H, Samaei, M, Samy, A, Sanabria, J, Sankararaman, S, Santric-Milicevic, M, Sardiwalla, Y, Sarveazad, A, Sathian, B, Sawhney, M, Saylan, M, Schneider, I, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, M, Shamsoddin, E, Shannawaz, M, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, J, Shetty, P, Shibuya, K, Shirkoohi, R, Shivakumar, K, Shivarov, V, Siabani, S, Siddappa Malleshappa, S, Silva, D, Singh, J, Sintayehu, Y, Skryabin, V, Skryabina, A, Soeberg, M, Sofi-Mahmudi, A, Sotoudeh, H, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, M, Sultan, I, Sultana, S, Sur, D, Szerencses, V, Szocska, M, Tabares-Seisdedos, R, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, I, Tan, K, Tat, V, Tedla, B, Tefera, Y, Tehrani-Banihashemi, A, Temsah, M, Tesfay, F, Tessema, G, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, H, Touvier, M, Tovani-Palone, M, Traini, E, Tran, B, Tran, K, Tran, M, Tripathy, J, Tusa, B, Ullah, I, Ullah, S, Umapathi, K, Unnikrishnan, B, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, D, Veroux, M, Violante, F, Vlassov, V, Vo, B, Volovici, V, Vu, G, Waheed, Y, Wamai, R, Ward, P, Wen, Y, Westerman, R, Winkler, A, Yadav, L, Yahyazadeh Jabbari, S, Yang, L, Yaya, S, Yazie, T, Yeshaw, Y, Yonemoto, N, Younis, M, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zare, F, Zastrozhin, M, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, I, Fitzmaurice, C, Murray, C, Force, L, Kocarnik J.M., Compton K., Dean F.E., Fu W., Gaw B.L., Harvey J.D., Henrikson H.J., Lu D., Pennini A., Xu R., Ababneh E., Abbasi-Kangevari M., Abbastabar H., Abd-Elsalam S.M., Abdoli A., Abedi A., Abidi H., Abolhassani H., Adedeji I.A., Adnani Q.E.S., Advani S.M., Afzal M.S., Aghaali M., Ahinkorah B.O., Ahmad S., Ahmad T., Ahmadi A., Ahmadi S., Ahmed Rashid T., Ahmed Salih Y., Akalu G.T., Aklilu A., Akram T., Akunna C.J., Al Hamad H., Alahdab F., Al-Aly Z., Ali S., Alimohamadi Y., Alipour V., Aljunid S.M., Alkhayyat M., Almasi-Hashiani A., Almasri N.A., Al-Maweri S.A.A., Almustanyir S., Alonso N., Alvis-Guzman N., Amu H., Anbesu E.W., Ancuceanu R., Ansari F., Ansari-Moghaddam A., Antwi M.H., Anvari D., Anyasodor A.E., Aqeel M., Arabloo J., Arab-Zozani M., Aremu O., Ariffin H., Aripov T., Arshad M., Artaman A., Arulappan J., Asemi Z., Asghari Jafarabadi M., Ashraf T., Atorkey P., Aujayeb A., Ausloos M., Awedew A.F., Ayala Quintanilla B.P., Ayenew T., Azab M.A., Azadnajafabad S., Azari Jafari A., Azarian G., Azzam A.Y., Badiye A.D., Bahadory S., Baig A.A., Baker J.L., Balakrishnan S., Banach M., Barnighausen T.W., Barone-Adesi F., Barra F., Barrow A., Behzadifar M., Belgaumi U.I., Bezabhe W.M.M., Bezabih Y.M., Bhagat D.S., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhaskar S., Bhattacharyya K., Bhojaraja V.S., Bibi S., Bijani A., Biondi A., Bisignano C., Bjorge T., Bleyer A., Blyuss O., Bolarinwa O.A., Bolla S.R., Braithwaite D., Brar A., Brenner H., Bustamante-Teixeira M.T., Butt N.S., Butt Z.A., Caetano dos Santos F.L., Cao Y., Carreras G., Catala-Lopez F., Cembranel F., Cerin E., Cernigliaro A., Chakinala R.C., Chattu S.K., Chattu V.K., Chaturvedi P., Chimed-Ochir O., Cho D.Y., Christopher D.J., Chu D.-T., Chung M.T., Conde J., Cortes S., Cortesi P.A., Costa V.M., Cunha A.R., Dadras O., Dagnew A.B., Dahlawi S.M.A., Dai X., Dandona L., Dandona R., Darwesh A.M., das Neves J., De la Hoz F.P., Demis A.B., Denova-Gutierrez E., Dhamnetiya D., Dhimal M.L., Dhimal M., Dianatinasab M., Diaz D., Djalalinia S., Do H.P., Doaei S., Dorostkar F., dos Santos Figueiredo F.W., Driscoll T.R., Ebrahimi H., Eftekharzadeh S., El Tantawi M., El-Abid H., Elbarazi I., Elhabashy H.R., Elhadi M., El-Jaafary S.I., Eshrati B., Eskandarieh S., Esmaeilzadeh F., Etemadi A., Ezzikouri S., Faisaluddin M., Faraon E.J.A., Fares J., Farzadfar F., Feroze A.H., Ferrero S., Ferro Desideri L., Filip I., Fischer F., Fisher J.L., Foroutan M., Fukumoto T., Gaal P.A., Gad M.M., Gadanya M.A., Gallus S., Gaspar Fonseca M., Getachew Obsa A., Ghafourifard M., Ghashghaee A., Ghith N., Gholamalizadeh M., Gilani S.A., Ginindza T.G., Gizaw A.T.T., Glasbey J.C., Golechha M., Goleij P., Gomez R.S., Gopalani S.V., Gorini G., Goudarzi H., Grosso G., Gubari M.I.M., Guerra M.R., Guha A., Gunasekera D.S., Gupta B., Gupta V.B., Gupta V.K., Gutierrez R.A., Hafezi-Nejad N., Haider M.R., Haj-Mirzaian A., Halwani R., Hamadeh R.R., Hameed S., Hamidi S., Hanif A., Haque S., Harlianto N.I., Haro J.M., Hasaballah A.I., Hassanipour S., Hay R.J., Hay S.I., Hayat K., Heidari G., Heidari M., Herrera-Serna B.Y., Herteliu C., Hezam K., Holla R., Hossain M.M., Hossain M.B.H., Hosseini M.-S., Hosseini M., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Hsairi M., Huang J., Hugo F.N., Hussain R., Hussein N.R., Hwang B.-F., Iavicoli I., Ibitoye S.E., Ida F., Ikuta K.S., Ilesanmi O.S., Ilic I.M., Ilic M.D., Irham L.M., Islam J.Y., Islam R.M., Islam S.M.S., Ismail N.E., Isola G., Iwagami M., Jacob L., Jain V., Jakovljevic M.B., Javaheri T., Jayaram S., Jazayeri S.B., Jha R.P., Jonas J.B., Joo T., Joseph N., Joukar F., Jurisson M., Kabir A., Kahrizi D., Kalankesh L.R., Kalhor R., Kaliyadan F., Kalkonde Y., Kamath A., Kameran Al-Salihi N., Kandel H., Kapoor N., Karch A., Kasa A.S., Katikireddi S.V., Kauppila J.H., Kavetskyy T., Kebede S.A., Keshavarz P., Keykhaei M., Khader Y.S., Khalilov R., Khan G., Khan M., Khan M.N., Khan M.A.B., Khang Y.-H., Khater A.M., Khayamzadeh M., Kim G.R., Kim Y.J., Kisa A., Kisa S., Kissimova-Skarbek K., Kopec J.A., Koteeswaran R., Koul P.A., Koulmane Laxminarayana S.L., Koyanagi A., Kucuk Bicer B., Kugbey N., Kumar G.A., Kumar N., Kurmi O.P., Kutluk T., La Vecchia C., Lami F.H., Landires I., Lauriola P., Lee S.-W., Lee S.W.H., Lee W.-C., Lee Y.H., Leigh J., Leong E., Li J., Li M.-C., Liu X., Loureiro J.A., Lunevicius R., Magdy Abd El Razek M., Majeed A., Makki A., Male S., Malik A.A., Mansournia M.A., Martini S., Masoumi S.Z., Mathur P., McKee M., Mehrotra R., Mendoza W., Menezes R.G., Mengesha E.W., Mesregah M.K., Mestrovic T., Miao Jonasson J., Miazgowski B., Miazgowski T., Michalek I.M., Miller T.R., Mirzaei H., Mirzaei H.R., Misra S., Mithra P., Moghadaszadeh M., Mohammad K.A., Mohammad Y., Mohammadi M., Mohammadi S.M., Mohammadian-Hafshejani A., Mohammed S., Moka N., Mokdad A.H., Molokhia M., Monasta L., Moni M.A., Moosavi M.A., Moradi Y., Moraga P., Morgado-Da-Costa J., Morrison S.D., Mosapour A., Mubarik S., Mwanri L., Nagarajan A.J., Nagaraju S.P., Nagata C., Naimzada M.D., Nangia V., Naqvi A.A., Narasimha Swamy S., Ndejjo R., Nduaguba S.O., Negoi I., Negru S.M., Neupane Kandel S., Nguyen C.T., Nguyen H.L.T., Niazi R.K., Nnaji C.A., Noor N.M., Nunez-Samudio V., Nzoputam C.I., Oancea B., Ochir C., Odukoya O.O., Ogbo F.A., Olagunju A.T., Olakunde B.O., Omar E., Omar Bali A.O., Omonisi A.E.E., Ong S., Onwujekwe O.E., Orru H., Ortega-Altamirano D.V., Otstavnov N., Otstavnov S.S., Owolabi M.O., P A M., Padubidri J.R., Pakshir K., Pana A., Panagiotakos D., Panda-Jonas S., Pardhan S., Park E.-C., Park E.-K., Pashazadeh Kan F., Patel H.K., Patel J.R., Pati S., Pattanshetty S.M., Paudel U., Pereira D.M., Pereira R.B., Perianayagam A., Pillay J.D., Pirouzpanah S., Pishgar F., Podder I., Postma M.J., Pourjafar H., Prashant A., Preotescu L., Rabiee M., Rabiee N., Radfar A., Radhakrishnan R.A., Radhakrishnan V., Rafiee A., Rahim F., Rahimzadeh S., Rahman M., Rahman M.A., Rahmani A.M., Rajai N., Rajesh A., Rakovac I., Ram P., Ramezanzadeh K., Ranabhat K., Ranasinghe P., Rao C.R., Rao S.J., Rawassizadeh R., Razeghinia M.S., Renzaho A.M.N., Rezaei N., Rezapour A., Roberts T.J., Rodriguez J.A.B., Rohloff P., Romoli M., Ronfani L., Roshandel G., Rwegerera G.M., Manjula S., Sabour S., Saddik B., Saeed U., Sahebkar A., Sahoo H., Salehi S., Salem M.R., Salimzadeh H., Samaei M., Samy A.M., Sanabria J., Sankararaman S., Santric-Milicevic M.M., Sardiwalla Y., Sarveazad A., Sathian B., Sawhney M., Saylan M., Schneider I.J.J., Sekerija M., Seylani A., Shafaat O., Shaghaghi Z., Shaikh M.A., Shamsoddin E., Shannawaz M., Sharma R., Sheikh A., Sheikhbahaei S., Shetty A., Shetty J.K., Shetty P.H., Shibuya K., Shirkoohi R., Shivakumar K.M., Shivarov V., Siabani S., Siddappa Malleshappa S.K., Silva D.A.S., Singh J.A., Sintayehu Y., Skryabin V.Y., Skryabina A.A., Soeberg M.J., Sofi-Mahmudi A., Sotoudeh H., Steiropoulos P., Straif K., Subedi R., Sufiyan M.B., Sultan I., Sultana S., Sur D., Szerencses V., Szocska M., Tabares-Seisdedos R., Tabuchi T., Tadbiri H., Taherkhani A., Takahashi K., Talaat I.M., Tan K.-K., Tat V.Y., Tedla B.A.A., Tefera Y.G., Tehrani-Banihashemi A., Temsah M., Tesfay F.H., Tessema G.A., Thapar R., Thavamani A., Thoguluva Chandrasekar V., Thomas N., Tohidinik H.R., Touvier M., Tovani-Palone M.R., Traini E., Tran B.X., Tran K.B., Tran M.T.N., Tripathy J.P., Tusa B.S., Ullah I., Ullah S., Umapathi K.K., Unnikrishnan B., Upadhyay E., Vacante M., Vaezi M., Valadan Tahbaz S., Velazquez D.Z., Veroux M., Violante F.S., Vlassov V., Vo B., Volovici V., Vu G.T., Waheed Y., Wamai R.G., Ward P., Wen Y.F., Westerman R., Winkler A.S., Yadav L., Yahyazadeh Jabbari S.H., Yang L., Yaya S., Yazie T.S.Y., Yeshaw Y., Yonemoto N., Younis M.Z., Yousefi Z., Yu C., Yuce D., Yunusa I., Zadnik V., Zare F., Zastrozhin M.S., Zastrozhina A., Zhang J., Zhong C., Zhou L., Zhu C., Ziapour A., Zimmermann I.R., Fitzmaurice C., Murray C.J.L., Force L.M., Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, Kuwait University (Kuwait), National University of Malaysia (Malasia), Alexander von Humboldt Foundation, Federal Ministry of Education & Research (Alemania), NIH - National Cancer Institute (NCI) (Estados Unidos), Unión Europea. Comisión Europea. European Research Council (ERC), Unión Europea. Comisión Europea. H2020, Novo Nordisk Foundation, National Health and Medical Research Council (Australia), Jazan University (Arabia Saudí), Romanian National Authority for Scientific Research and Innovation, Ministry of Education (Brasil), National Heart Foundation of Australia, Ministry of Education, Science and Technological Development (Serbia), NHS - Research Scotland (Reino Unido), Medical Research Council (Reino Unido), Scottish Government (Reino Unido), Jatiya Kabi Kazi Nazrul Islam University (Bangladesh), Xiamen University (Malasia), Manipal Academy of Higher Education (India), Sistema Nacional de Investigación (Panamá), Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá), King College London, National Health Service (Reino Unido), Government of the Russian Federation, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), National Council for Scientific and Technological Development (Brasil), Cancer Prevention and Research Institute of Texas (Estados Unidos), Fundação para a Ciência e Tecnologia (Portugal), Neurosurgery, Kocarnik, J. M., Compton, K., Dean, F. E., Fu, W., Gaw, B. L., Harvey, J. D., Henrikson, H. J., Lu, D., Pennini, A., Xu, R., Ababneh, E., Abbasi-Kangevari, M., Abbastabar, H., Abd-Elsalam, S. M., Abdoli, A., Abedi, A., Abidi, H., Abolhassani, H., Adedeji, I. A., Adnani, Q. E. S., Advani, S. M., Afzal, M. S., Aghaali, M., Ahinkorah, B. O., Ahmad, S., Ahmad, T., Ahmadi, A., Ahmadi, S., Ahmed Rashid, T., Ahmed Salih, Y., Akalu, G. T., Aklilu, A., Akram, T., Akunna, C. J., Al Hamad, H., Alahdab, F., Al-Aly, Z., Ali, S., Alimohamadi, Y., Alipour, V., Aljunid, S. M., Alkhayyat, M., Almasi-Hashiani, A., Almasri, N. A., Al-Maweri, S. A. A., Almustanyir, S., Alonso, N., Alvis-Guzman, N., Amu, H., Anbesu, E. W., Ancuceanu, R., Ansari, F., Ansari-Moghaddam, A., Antwi, M. H., Anvari, D., Anyasodor, A. E., Aqeel, M., Arabloo, J., Arab-Zozani, M., Aremu, O., Ariffin, H., Aripov, T., Arshad, M., Artaman, A., Arulappan, J., Asemi, Z., Asghari Jafarabadi, M., Ashraf, T., Atorkey, P., Aujayeb, A., Ausloos, M., Awedew, A. F., Ayala Quintanilla, B. P., Ayenew, T., Azab, M. A., Azadnajafabad, S., Azari Jafari, A., Azarian, G., Azzam, A. Y., Badiye, A. D., Bahadory, S., Baig, A. A., Baker, J. L., Balakrishnan, S., Banach, M., Barnighausen, T. W., Barone-Adesi, F., Barra, F., Barrow, A., Behzadifar, M., Belgaumi, U. I., Bezabhe, W. M. M., Bezabih, Y. M., Bhagat, D. S., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhaskar, S., Bhattacharyya, K., Bhojaraja, V. S., Bibi, S., Bijani, A., Biondi, A., Bisignano, C., Bjorge, T., Bleyer, A., Blyuss, O., Bolarinwa, O. A., Bolla, S. R., Braithwaite, D., Brar, A., Brenner, H., Bustamante-Teixeira, M. T., Butt, N. S., Butt, Z. A., Caetano Dos Santos, F. L., Cao, Y., Carreras, G., Catala-Lopez, F., Cembranel, F., Cerin, E., Cernigliaro, A., Chakinala, R. C., Chattu, S. K., Chattu, V. K., Chaturvedi, P., Chimed-Ochir, O., Cho, D. Y., Christopher, D. J., Chu, D. -T., Chung, M. T., Conde, J., Cortes, S., Cortesi, P. A., Costa, V. M., Cunha, A. R., Dadras, O., Dagnew, A. B., Dahlawi, S. M. A., Dai, X., Dandona, L., Dandona, R., Darwesh, A. M., Das Neves, J., De La Hoz, F. P., Demis, A. B., Denova-Gutierrez, E., Dhamnetiya, D., Dhimal, M. L., Dhimal, M., Dianatinasab, M., Diaz, D., Djalalinia, S., Do, H. P., Doaei, S., Dorostkar, F., Dos Santos Figueiredo, F. W., Driscoll, T. R., Ebrahimi, H., Eftekharzadeh, S., El Tantawi, M., El-Abid, H., Elbarazi, I., Elhabashy, H. R., Elhadi, M., El-Jaafary, S. I., Eshrati, B., Eskandarieh, S., Esmaeilzadeh, F., Etemadi, A., Ezzikouri, S., Faisaluddin, M., Faraon, E. J. A., Fares, J., Farzadfar, F., Feroze, A. H., Ferrero, S., Ferro Desideri, L., Filip, I., Fischer, F., Fisher, J. L., Foroutan, M., Fukumoto, T., Gaal, P. A., Gad, M. M., Gadanya, M. A., Gallus, S., Gaspar Fonseca, M., Getachew Obsa, A., Ghafourifard, M., Ghashghaee, A., Ghith, N., Gholamalizadeh, M., Gilani, S. A., Ginindza, T. G., Gizaw, A. T. T., Glasbey, J. C., Golechha, M., Goleij, P., Gomez, R. S., Gopalani, S. V., Gorini, G., Goudarzi, H., Grosso, G., Gubari, M. I. M., Guerra, M. R., Guha, A., Gunasekera, D. S., Gupta, B., Gupta, V. B., Gupta, V. K., Gutierrez, R. A., Hafezi-Nejad, N., Haider, M. R., Haj-Mirzaian, A., Halwani, R., Hamadeh, R. R., Hameed, S., Hamidi, S., Hanif, A., Haque, S., Harlianto, N. I., Haro, J. M., Hasaballah, A. I., Hassanipour, S., Hay, R. J., Hay, S. I., Hayat, K., Heidari, G., Heidari, M., Herrera-Serna, B. Y., Herteliu, C., Hezam, K., Holla, R., Hossain, M. M., Hossain, M. B. H., Hosseini, M. -S., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Huang, J., Hugo, F. N., Hussain, R., Hussein, N. R., Hwang, B. -F., Iavicoli, I., Ibitoye, S. E., Ida, F., Ikuta, K. S., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Irham, L. M., Islam, J. Y., Islam, R. M., Islam, S. M. S., Ismail, N. E., Isola, G., Iwagami, M., Jacob, L., Jain, V., Jakovljevic, M. B., Javaheri, T., Jayaram, S., Jazayeri, S. B., Jha, R. P., Jonas, J. B., Joo, T., Joseph, N., Joukar, F., Jurisson, M., Kabir, A., Kahrizi, D., Kalankesh, L. R., Kalhor, R., Kaliyadan, F., Kalkonde, Y., Kamath, A., Kameran Al-Salihi, N., Kandel, H., Kapoor, N., Karch, A., Kasa, A. S., Katikireddi, S. V., Kauppila, J. H., Kavetskyy, T., Kebede, S. A., Keshavarz, P., Keykhaei, M., Khader, Y. S., Khalilov, R., Khan, G., Khan, M., Khan, M. N., Khan, M. A. B., Khang, Y. -H., Khater, A. M., Khayamzadeh, M., Kim, G. R., Kim, Y. J., Kisa, A., Kisa, S., Kissimova-Skarbek, K., Kopec, J. A., Koteeswaran, R., Koul, P. A., Koulmane Laxminarayana, S. L., Koyanagi, A., Kucuk Bicer, B., Kugbey, N., Kumar, G. A., Kumar, N., Kurmi, O. P., Kutluk, T., La Vecchia, C., Lami, F. H., Landires, I., Lauriola, P., Lee, S. -W., Lee, S. W. H., Lee, W. -C., Lee, Y. H., Leigh, J., Leong, E., Li, J., Li, M. -C., Liu, X., Loureiro, J. A., Lunevicius, R., Magdy Abd El Razek, M., Majeed, A., Makki, A., Male, S., Malik, A. A., Mansournia, M. A., Martini, S., Masoumi, S. Z., Mathur, P., Mckee, M., Mehrotra, R., Mendoza, W., Menezes, R. G., Mengesha, E. W., Mesregah, M. K., Mestrovic, T., Miao Jonasson, J., Miazgowski, B., Miazgowski, T., Michalek, I. M., Miller, T. R., Mirzaei, H., Mirzaei, H. R., Misra, S., Mithra, P., Moghadaszadeh, M., Mohammad, K. A., Mohammad, Y., Mohammadi, M., Mohammadi, S. M., Mohammadian-Hafshejani, A., Mohammed, S., Moka, N., Mokdad, A. H., Molokhia, M., Monasta, L., Moni, M. A., Moosavi, M. A., Moradi, Y., Moraga, P., Morgado-Da-Costa, J., Morrison, S. D., Mosapour, A., Mubarik, S., Mwanri, L., Nagarajan, A. J., Nagaraju, S. P., Nagata, C., Naimzada, M. D., Nangia, V., Naqvi, A. A., Narasimha Swamy, S., Ndejjo, R., Nduaguba, S. O., Negoi, I., Negru, S. M., Neupane Kandel, S., Nguyen, C. T., Nguyen, H. L. T., Niazi, R. K., Nnaji, C. A., Noor, N. M., Nunez-Samudio, V., Nzoputam, C. I., Oancea, B., Ochir, C., Odukoya, O. O., Ogbo, F. A., Olagunju, A. T., Olakunde, B. O., Omar, E., Omar Bali, A., Omonisi, A. E. E., Ong, S., Onwujekwe, O. E., Orru, H., Ortega-Altamirano, D. V., Otstavnov, N., Otstavnov, S. S., Owolabi, M. O., P A, M., Padubidri, J. R., Pakshir, K., Pana, A., Panagiotakos, D., Panda-Jonas, S., Pardhan, S., Park, E. -C., Park, E. -K., Pashazadeh Kan, F., Patel, H. K., Patel, J. R., Pati, S., Pattanshetty, S. M., Paudel, U., Pereira, D. M., Pereira, R. B., Perianayagam, A., Pillay, J. D., Pirouzpanah, S., Pishgar, F., Podder, I., Postma, M. J., Pourjafar, H., Prashant, A., Preotescu, L., Rabiee, M., Rabiee, N., Radfar, A., Radhakrishnan, R. A., Radhakrishnan, V., Rafiee, A., Rahim, F., Rahimzadeh, S., Rahman, M., Rahman, M. A., Rahmani, A. M., Rajai, N., Rajesh, A., Rakovac, I., Ram, P., Ramezanzadeh, K., Ranabhat, K., Ranasinghe, P., Rao, C. R., Rao, S. J., Rawassizadeh, R., Razeghinia, M. S., Renzaho, A. M. N., Rezaei, N., Rezapour, A., Roberts, T. J., Rodriguez, J. A. B., Rohloff, P., Romoli, M., Ronfani, L., Roshandel, G., Rwegerera, G. M., Manjula, S., Sabour, S., Saddik, B., Saeed, U., Sahebkar, A., Sahoo, H., Salehi, S., Salem, M. R., Salimzadeh, H., Samaei, M., Samy, A. M., Sanabria, J., Sankararaman, S., Santric-Milicevic, M. M., Sardiwalla, Y., Sarveazad, A., Sathian, B., Sawhney, M., Saylan, M., Schneider, I. J. C., Sekerija, M., Seylani, A., Shafaat, O., Shaghaghi, Z., Shaikh, M. A., Shamsoddin, E., Shannawaz, M., Sharma, R., Sheikh, A., Sheikhbahaei, S., Shetty, A., Shetty, J. K., Shetty, P. H., Shibuya, K., Shirkoohi, R., Shivakumar, K. M., Shivarov, V., Siabani, S., Siddappa Malleshappa, S. K., Silva, D. A. S., Singh, J. A., Sintayehu, Y., Skryabin, V. Y., Skryabina, A. A., Soeberg, M. J., Sofi-Mahmudi, A., Sotoudeh, H., Steiropoulos, P., Straif, K., Subedi, R., Sufiyan, M. B., Sultan, I., Sultana, S., Sur, D., Szerencses, V., Szocska, M., Tabares-Seisdedos, R., Tabuchi, T., Tadbiri, H., Taherkhani, A., Takahashi, K., Talaat, I. M., Tan, K. -K., Tat, V. Y., Tedla, B. A. A., Tefera, Y. G., Tehrani-Banihashemi, A., Temsah, M. -H., Tesfay, F. H., Tessema, G. A., Thapar, R., Thavamani, A., Thoguluva Chandrasekar, V., Thomas, N., Tohidinik, H. R., Touvier, M., Tovani-Palone, M. R., Traini, E., Tran, B. X., Tran, K. B., Tran, M. T. N., Tripathy, J. P., Tusa, B. S., Ullah, I., Ullah, S., Umapathi, K. K., Unnikrishnan, B., Upadhyay, E., Vacante, M., Vaezi, M., Valadan Tahbaz, S., Velazquez, D. Z., Veroux, M., Violante, F. S., Vlassov, V., Vo, B., Volovici, V., Vu, G. T., Waheed, Y., Wamai, R. G., Ward, P., Wen, Y. F., Westerman, R., Winkler, A. S., Yadav, L., Yahyazadeh Jabbari, S. H., Yang, L., Yaya, S., Yazie, T. S. Y., Yeshaw, Y., Yonemoto, N., Younis, M. Z., Yousefi, Z., Yu, C., Yuce, D., Yunusa, I., Zadnik, V., Zare, F., Zastrozhin, M. S., Zastrozhina, A., Zhang, J., Zhong, C., Zhou, L., Zhu, C., Ziapour, A., Zimmermann, I. R., Fitzmaurice, C., Murray, C. J. L., and Force, L. M.
Subjects: Cancer Research, GBD, 195 COUNTRIES, Global Health, 1117 Public Health and Health Services, Global Burden of Disease, SDG 3 - Good Health and Well-being, WORLDWIDE, Risk Factors, Neoplasms, SURVEILLANCE, SUPPORT, Global Burden of Disease 2019 Cancer Collaboration, Prevalence, Online First, cancer, Humans, 1112 Oncology and Carcinogenesis, public health, cancer, burden of diseases, PROGRESS, Original Investigation, Global burden, Science & Technology, CHALLENGES, Research, Incidence, Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 [VDP], COVID-19, 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services, Disability-Adjusted Life Years, mortality, STATISTICS, Oncology, Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019, HEALTH-CARE, TERRITORIES, Quality-Adjusted Life Years, Life Sciences & Biomedicine, Comments
Abstract: Key Points Question What was the burden of cancer globally and across Sociodemographic Index (SDI) groupings in 2019, and how has incidence, morbidity, and mortality changed since 2010? Findings In this systematic analysis, there were 23.6 million new global cancer cases in 2019 (17.2 million when excluding those with nonmelanoma skin cancer), 10.0 million cancer deaths, and an estimated 250 million disability-adjusted life years estimated to be due to cancer; since 2010, these represent increases of 26.3%, 20.9%, and 16.0%, respectively. Absolute cancer burden increased in all SDI quintiles since 2010, but the largest percentage increases occurred in the low and low-middle SDI quintiles. Meanings The study results suggest that increased cancer prevention and control efforts are needed to equitably address the evolving and increasing burden of cancer across the SDI spectrum., Importance The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. Conclusions and Relevance The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world., The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 examines cancer burden and trends globally for 204 countries and territories and by Socio-demographic Index quintiles from 2010 to 2019.
Published: 2022
Full Text: View/download PDF

6. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

Author: Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Ababneh, E, Abbasi-Kangevari, M, Abbastabar, H, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abidi, H, Abolhassani, H, Adedeji, IA, Adnani, QES, Advani, SM, Afzal, MS, Aghaali, M, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, A, Ahmadi, S, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, GT, Aklilu, A, Akram, T, Akunna, CJ, Al Hamad, H, Alahdab, F, Al-Aly, Z, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Almasi-Hashiani, A, Almasri, NA, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alvis-Guzman, N, Amu, H, Anbesu, EW, Ancuceanu, R, Ansari, F, Ansari-Moghaddam, A, Antwi, MH, Anvari, D, Anyasodor, AE, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aremu, O, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, Shariful, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, Nduaguba, SO, Negoi, I, Negru, SM, Neupane Kandel, S, Nguyen, CT, Nguyen, HLT, Niazi, RK, Nnaji, CA, Noor, NM, Nuñez-Samudio, V, Nzoputam, CI, Oancea, B, Ochir, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Olakunde, BO, Omar, E, Omar Bali, A, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Ortega-Altamirano, DV, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P A, M, Padubidri, JR, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Pardhan, S, Park, E-C, Park, E-K, Pashazadeh Kan, F, Patel, HK, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, DM, Pereira, RB, Perianayagam, A, Pillay, JD, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, MJ, Pourjafar, H, Prashant, A, Preotescu, L, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Rahmani, AM, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rawassizadeh, R, Razeghinia, MS, Renzaho, AMN, Rezaei, N, Rezapour, A, Roberts, TJ, Rodriguez, JAB, Rohloff, P, Romoli, M, Ronfani, L, Roshandel, G, Rwegerera, GM, S, M, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Salem, MR, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sankararaman, S, Santric-Milicevic, MM, Sardiwalla, Y, Sarveazad, A, Sathian, B, Sawhney, M, Saylan, M, Schneider, IJC, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, JK, Shetty, PH, Shibuya, K, Shirkoohi, R, Shivakumar, KM, Shivarov, V, Siabani, S, Siddappa Malleshappa, SK, Silva, DAS, Singh, JA, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Murray, CJL, Force, LM, Global Burden of Disease 2019 Cancer Collaboration, Kocarnik, JM, Compton, K, Dean, FE, Fu, W, Gaw, BL, Harvey, JD, Henrikson, HJ, Lu, D, Pennini, A, Xu, R, Ababneh, E, Abbasi-Kangevari, M, Abbastabar, H, Abd-Elsalam, SM, Abdoli, A, Abedi, A, Abidi, H, Abolhassani, H, Adedeji, IA, Adnani, QES, Advani, SM, Afzal, MS, Aghaali, M, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, A, Ahmadi, S, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, GT, Aklilu, A, Akram, T, Akunna, CJ, Al Hamad, H, Alahdab, F, Al-Aly, Z, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Almasi-Hashiani, A, Almasri, NA, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alvis-Guzman, N, Amu, H, Anbesu, EW, Ancuceanu, R, Ansari, F, Ansari-Moghaddam, A, Antwi, MH, Anvari, D, Anyasodor, AE, Aqeel, M, Arabloo, J, Arab-Zozani, M, Aremu, O, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Asemi, Z, Asghari Jafarabadi, M, Ashraf, T, Atorkey, P, Aujayeb, A, Ausloos, M, Awedew, AF, Ayala Quintanilla, BP, Ayenew, T, Azab, MA, Azadnajafabad, S, Azari Jafari, A, Azarian, G, Azzam, AY, Badiye, AD, Bahadory, S, Baig, AA, Baker, JL, Balakrishnan, S, Banach, M, Bärnighausen, TW, Barone-Adesi, F, Barra, F, Barrow, A, Behzadifar, M, Belgaumi, UI, Bezabhe, WMM, Bezabih, YM, Bhagat, DS, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bhojaraja, VS, Bibi, S, Bijani, A, Biondi, A, Bisignano, C, Bjørge, T, Bleyer, A, Blyuss, O, Bolarinwa, OA, Bolla, SR, Braithwaite, D, Brar, A, Brenner, H, Bustamante-Teixeira, MT, Butt, NS, Butt, ZA, Caetano Dos Santos, FL, Cao, Y, Carreras, G, Catalá-López, F, Cembranel, F, Cerin, E, Cernigliaro, A, Chakinala, RC, Chattu, SK, Chattu, VK, Chaturvedi, P, Chimed-Ochir, O, Cho, DY, Christopher, DJ, Chu, D-T, Chung, MT, Conde, J, Cortés, S, Cortesi, PA, Costa, VM, Cunha, AR, Dadras, O, Dagnew, AB, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Darwesh, AM, das Neves, J, De la Hoz, FP, Demis, AB, Denova-Gutiérrez, E, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Do, HP, Doaei, S, Dorostkar, F, Dos Santos Figueiredo, FW, Driscoll, TR, Ebrahimi, H, Eftekharzadeh, S, El Tantawi, M, El-Abid, H, Elbarazi, I, Elhabashy, HR, Elhadi, M, El-Jaafary, SI, Eshrati, B, Eskandarieh, S, Esmaeilzadeh, F, Etemadi, A, Ezzikouri, S, Faisaluddin, M, Faraon, EJA, Fares, J, Farzadfar, F, Feroze, AH, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Fisher, JL, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gallus, S, Gaspar Fonseca, M, Getachew Obsa, A, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gilani, SA, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Golechha, M, Goleij, P, Gomez, RS, Gopalani, SV, Gorini, G, Goudarzi, H, Grosso, G, Gubari, MIM, Guerra, MR, Guha, A, Gunasekera, DS, Gupta, B, Gupta, VB, Gupta, VK, Gutiérrez, RA, Hafezi-Nejad, N, Haider, MR, Haj-Mirzaian, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Haque, S, Harlianto, NI, Haro, JM, Hasaballah, AI, Hassanipour, S, Hay, RJ, Hay, SI, Hayat, K, Heidari, G, Heidari, M, Herrera-Serna, BY, Herteliu, C, Hezam, K, Holla, R, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsairi, M, Huang, J, Hugo, FN, Hussain, R, Hussein, NR, Hwang, B-F, Iavicoli, I, Ibitoye, SE, Ida, F, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Islam, RM, Islam, Shariful, Ismail, NE, Isola, G, Iwagami, M, Jacob, L, Jain, V, Jakovljevic, MB, Javaheri, T, Jayaram, S, Jazayeri, SB, Jha, RP, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jürisson, M, Kabir, A, Kahrizi, D, Kalankesh, LR, Kalhor, R, Kaliyadan, F, Kalkonde, Y, Kamath, A, Kameran Al-Salihi, N, Kandel, H, Kapoor, N, Karch, A, Kasa, AS, Katikireddi, SV, Kauppila, JH, Kavetskyy, T, Kebede, SA, Keshavarz, P, Keykhaei, M, Khader, YS, Khalilov, R, Khan, G, Khan, M, Khan, MN, Khan, MAB, Khang, Y-H, Khater, AM, Khayamzadeh, M, Kim, GR, Kim, YJ, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kopec, JA, Koteeswaran, R, Koul, PA, Koulmane Laxminarayana, SL, Koyanagi, A, Kucuk Bicer, B, Kugbey, N, Kumar, GA, Kumar, N, Kurmi, OP, Kutluk, T, La Vecchia, C, Lami, FH, Landires, I, Lauriola, P, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YH, Leigh, J, Leong, E, Li, J, Li, M-C, Liu, X, Loureiro, JA, Lunevicius, R, Magdy Abd El Razek, M, Majeed, A, Makki, A, Male, S, Malik, AA, Mansournia, MA, Martini, S, Masoumi, SZ, Mathur, P, McKee, M, Mehrotra, R, Mendoza, W, Menezes, RG, Mengesha, EW, Mesregah, MK, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirzaei, H, Mirzaei, HR, Misra, S, Mithra, P, Moghadaszadeh, M, Mohammad, KA, Mohammad, Y, Mohammadi, M, Mohammadi, SM, Mohammadian-Hafshejani, A, Mohammed, S, Moka, N, Mokdad, AH, Molokhia, M, Monasta, L, Moni, MA, Moosavi, MA, Moradi, Y, Moraga, P, Morgado-da-Costa, J, Morrison, SD, Mosapour, A, Mubarik, S, Mwanri, L, Nagarajan, AJ, Nagaraju, SP, Nagata, C, Naimzada, MD, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Ndejjo, R, Nduaguba, SO, Negoi, I, Negru, SM, Neupane Kandel, S, Nguyen, CT, Nguyen, HLT, Niazi, RK, Nnaji, CA, Noor, NM, Nuñez-Samudio, V, Nzoputam, CI, Oancea, B, Ochir, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Olakunde, BO, Omar, E, Omar Bali, A, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Ortega-Altamirano, DV, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P A, M, Padubidri, JR, Pakshir, K, Pana, A, Panagiotakos, D, Panda-Jonas, S, Pardhan, S, Park, E-C, Park, E-K, Pashazadeh Kan, F, Patel, HK, Patel, JR, Pati, S, Pattanshetty, SM, Paudel, U, Pereira, DM, Pereira, RB, Perianayagam, A, Pillay, JD, Pirouzpanah, S, Pishgar, F, Podder, I, Postma, MJ, Pourjafar, H, Prashant, A, Preotescu, L, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Rafiee, A, Rahim, F, Rahimzadeh, S, Rahman, M, Rahman, MA, Rahmani, AM, Rajai, N, Rajesh, A, Rakovac, I, Ram, P, Ramezanzadeh, K, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rawassizadeh, R, Razeghinia, MS, Renzaho, AMN, Rezaei, N, Rezapour, A, Roberts, TJ, Rodriguez, JAB, Rohloff, P, Romoli, M, Ronfani, L, Roshandel, G, Rwegerera, GM, S, M, Sabour, S, Saddik, B, Saeed, U, Sahebkar, A, Sahoo, H, Salehi, S, Salem, MR, Salimzadeh, H, Samaei, M, Samy, AM, Sanabria, J, Sankararaman, S, Santric-Milicevic, MM, Sardiwalla, Y, Sarveazad, A, Sathian, B, Sawhney, M, Saylan, M, Schneider, IJC, Sekerija, M, Seylani, A, Shafaat, O, Shaghaghi, Z, Shaikh, MA, Shamsoddin, E, Shannawaz, M, Sharma, R, Sheikh, A, Sheikhbahaei, S, Shetty, A, Shetty, JK, Shetty, PH, Shibuya, K, Shirkoohi, R, Shivakumar, KM, Shivarov, V, Siabani, S, Siddappa Malleshappa, SK, Silva, DAS, Singh, JA, Sintayehu, Y, Skryabin, VY, Skryabina, AA, Soeberg, MJ, Sofi-Mahmudi, A, Sotoudeh, H, Steiropoulos, P, Straif, K, Subedi, R, Sufiyan, MB, Sultan, I, Sultana, S, Sur, D, Szerencsés, V, Szócska, M, Tabarés-Seisdedos, R, Tabuchi, T, Tadbiri, H, Taherkhani, A, Takahashi, K, Talaat, IM, Tan, K-K, Tat, VY, Tedla, BAA, Tefera, YG, Tehrani-Banihashemi, A, Temsah, M-H, Tesfay, FH, Tessema, GA, Thapar, R, Thavamani, A, Thoguluva Chandrasekar, V, Thomas, N, Tohidinik, HR, Touvier, M, Tovani-Palone, MR, Traini, E, Tran, BX, Tran, KB, Tran, MTN, Tripathy, JP, Tusa, BS, Ullah, I, Ullah, S, Umapathi, KK, Unnikrishnan, B, Upadhyay, E, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Velazquez, DZ, Veroux, M, Violante, FS, Vlassov, V, Vo, B, Volovici, V, Vu, GT, Waheed, Y, Wamai, RG, Ward, P, Wen, YF, Westerman, R, Winkler, AS, Yadav, L, Yahyazadeh Jabbari, SH, Yang, L, Yaya, S, Yazie, TSY, Yeshaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zare, F, Zastrozhin, MS, Zastrozhina, A, Zhang, J, Zhong, C, Zhou, L, Zhu, C, Ziapour, A, Zimmermann, IR, Fitzmaurice, C, Murray, CJL, and Force, LM
Abstract: Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low
Published: 2021

7. Nursing in the ICU: comparison of the NAS and time on bedside

Author: Moura, Jr, DF, Lucinio, NM, Pardini, A, Shiramizo, S, Ribas, MR, Morbek, RA, Rosa, ELPCA, Yamashita, MAA, Guerra, MR, and Silva, E
Published: 2011
Full Text: View/download PDF

8. Suicidal ideation in a European Huntington's disease population

Author: Hubers, Aa, van Duijn, E, Roos, Ra, Craufurd, D, Rickards, H, Bernhard Landwehrmeyer, G, van der Mast RC, Giltay, Ej, Bachoud Lévi AC, Bentivoglio, Ar, Biunno, I, Bonelli, Rm, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Handley, Oj, Heiberg, A, Llmann, Ti, Landwehrmeyer, Gb, Levey, J, Ramos Arroyo MA, Nielsen, Je, Prokoivisto, S, Päivärinta, M, Rojo Sebastián, A, Tabrizi, Sj, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlström, J, Barth, K, Correia Guedes, L, Finisterra, Am, Garde, Mb, Bos, R, Betz, S, Callaghan, J, Fullam, R, Ecker, D, Nielsen, Mg, Hvalstedt, C, Held, C, Koppers, K, Laurà, M, Horta, Sm, Descals, Am, Mestre, T, Minster, S, Monza, D, Mütze, L, Oehmen, M, Townhill, J, Orth, M, Padieu, H, Paterski, L, Peppa, N, Pro Koivisto, S, Roedig, V, Rialland, A, Røren, N, Šašinková, P, Seliverstov, Y, Cubillo, Pt, Walsem, Mr, Wright, A, da Silva WV, Witjes Ané MN, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Herranhof, B, Holl, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Scheibl, M, Hecht, K, Lilek, S, Müller, N, Schöggl, H, Ullah, J, Brugger, F, Hepperger, C, Hotter, A, Seppi, K, Wenning, G, Buratti, L, Hametner, Em, Holas, C, Hussl, A, Poewe, W, Braunwarth, Em, Sprenger, F, Müller, C, Sinadinosa, D, Walleczek, Am, Ladurner, G, Staffen, W, Flamez, A, Morez, V, de Raedt, S, Boogaerts, A, van Reijen, D, Klempíř, J, Majerová, V, Roth, J, Hartikainen, P, Hiivola, H, Martikainen, K, Tuuha, K, Ignatius, J, Kärppä, M, Åman, J, Mustonen, A, Kajula, O, Santala, M, Allain, P, Guérid, Ma, Gohier, B, Olivier, A, Prundean, A, Scherer Gagou, C, Verny, C, Bost, M, Babiloni, B, Debruxelles, S, Duché, C, Goizet, C, Lafoucrière, D, Jameau, L, Spampinato, U, De Bruycker, C, Cabaret, M, Carette, As, Defebvre, L, Decorte, E, Delval, A, Delliaux, M, Destee, A, Dujardin, K, Peter, M, Plomhouse, L, Sablonnière, B, Simonin, C, Lemaire, Mh, Manouvrier, S, Thibault Tanchou, S, Vuillaume, I, Krystkowiak, P, Duru, C, Roussel, M, Wannepain, S, Berrissoul, H, Bellonet, M, Courtin, F, Mantaux, B, Fasquel, V, Godefroy, O, Azulay, Jp, Fluchère, F, Delfini, M, Eusebio, A, Mundler, L, Longato, N, Rudolf, G, Steinmetz, G, Tranchant, C, Wagner, C, Zimmermann, M, Marcel, C, Calvas, F, Pariente, J, Démonet, Jf, Cheriet, S, Kosinski, Cm, Milkereit, E, Probst, D, Reetz, K, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Gelderblom, H, Priller, J, Prüß, H, Spruth, Ej, Andrich, J, Ellrichmann, G, Hoffmann, R, Kaminski, B, Saft, C, Stamm, C, Lange, H, Bosredon, C, Maass, A, Schmidt, S, Storch, A, Wolz, M, Kohl, Z, Winkler, J, Capetian, P, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Goerendt, I, Hidding, U, Lewerenz, J, Münchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Diercks, G, Dressler, D, Gorzolla, H, Schrader, C, Tacik, P, Heinicke, W, Longinus, B, Bürk, K, Möller, Jc, Rissling, I, Mühlau, M, Peinemann, A, Städtler, M, Weindl, A, Winkelmann, J, Ziegler, C, Bohlen, S, Hölzner, E, Reilmann, R, Dose, M, Leythaeuser, G, Marquard, R, Raab, T, Schrenk, C, Schuierer, M, Buck, A, Connemann, J, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Schwenk, D, Süßmuth, S, Trautmann, S, Weydt, P, Cormio, C, Sciruicchio, V, Serpino, C, Tommaso, M, Capellari, S, Cortelli, P, Gallassi, R, Poda, R, Rizzo, G, Scaglione, C, Bertini, E, Ghelli, E, Ginestroni, A, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, di Poggio MB, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Bella, D, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Paridi, D, Soliveri, P, Tomasello, C, De Michele, G, Di Maio, L, Salvatore, E, Rinaldi, C, Rossi, F, Massarelli, M, Roca, A, Ammendola, S, Russo, Cv, Squitieri, F, Elifani, F, Maglione, V, Di Pardo, A, Alberti, S, Griguoli, A, Amico, E, Martino, T, Petrollini, M, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Piano, C, Chiara, P, Quaranta, D, Romano, Silvia, Soleti, F, Spadaro, M, Romano, S, van Hout MS, van Vugt JP, Weert, A, Bolwijn, J, Dekker, M, Leenders, K, Kremer, Hp, Dumas, Em, van den Bogaard SJ, 't Hart EP, Økland, E, Hauge, E, Tyvoll, H, Frich, J, Aaserud, O, Wehus, R, Bjørgo, K, Fannemel, M, Gørvell, P, Lorentzen, E, Koivisto, Sp, Retterstøl, L, Overland, T, Stokke, B, Sando, B, Dziadkiewicz, A, Nowak, M, Robowski, P, Sitek, E, Slawek, J, Soltan, W, Szinwelski, M, Blaszcyk, M, Boczarska Jedynak, M, Ciach Wysocka, E, Gorzkowska, A, Jasinska Myga, B, Opala, G, Kłodowska Duda, G, Stompel, D, Banaszkiewicz, K, Boćwińska, D, Szczudlik, A, Rudzińska, M, Wójcik, M, Dec, M, Krawczyk, M, Jaremek, Kb, Szczygieł, E, Stenwak, A, Ielewska, Aw, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Sempołowicz, J, Samara, H, Wiśniewski, B, Janik, P, Gogol, A, Kwiecinski, H, Jamrozik, Z, Kaminska, A, Antczak, J, Jachinska, K, Rakowicz, M, Richter, P, Rola, R, Ryglewicz, D, Sienkiewicz Jarosz, H, Stępniak, I, Witkowski, G, Zdzienicka, E, Sułek, A, Krysa, W, Zieora Jakutowicz, K, Júlio, F, Januário, C, Coelho, M, Mendes, T, Valadas, A, Timóteo, Â, Costa, C, Cavaco, S, Damásio, J, Loureiro, R, Magalhães, M, Andrade, C, Gago, M, Garrett, C, Guerra, Mr, Lima, J, Massano, J, Meireles, J, Herrera, Cd, Garcia, Pm, Barrero, F, Morales, B, Cubo, E, Mariscal, N, Sánchez, J, Alonso Frech, F, Perez, Mr, Fenollar, M, García, Rg, Quiroga, Pp, Rivera, Sv, Villanueva, C, Alegre, J, Bascuñana, M, Caldentey, Jg, Ventura, Mf, Ribas, Gg, Yébenes, Jg, López Sendón Moreno JL, García Ruíz PJ, Martínez Descals, A, Artiga, Mj, Sánchez, V, Guerrero, R, Bárcenas, Ah, Noguera Perea MF, Fortuna, L, Martirio, M, Torres, A, Reinante, G, Moreau, Lv, Barbera, Ma, Guia, Db, Hernanz, Lc, Catena, Jl, Sebastián, Ar, Ferrer, Pq, Carruesco, Gt, Bas, J, Busquets, N, Calopa, M, Elorza, Md, Díez AjaLópez, C, Terol, Sd, Robert, Mf, Ruíz, Bg, Casado, Ag, Martínez, Ih, Viladrich, Cm, Càrdenas, Rp, Roca, E, Llesoy, Jr, Idiago, Jm, Vergara, Mr, García, Ss, Riballo, Av, González, Sg, Guisasola, Lm, Salvador, C, San Martín ES, González, M, Gorospe, A, Legarda, I, Arques, Pn, Torres Rodríguez MJ, Vives, B, Gaston, I, Martinez Jaurrieta MD, Manuel, J, Moreno, G, Peña, Jc, Avarvarei, Ld, Bastida, Am, Recio, Mf, Vergé, Lr, Sánchez, Vs, Carrillo, F, Cáceres, Mt, Mir, P, Suarez, Mj, Bosca, M, Burguera, Ja, Garcia, Ac, Brugada, Fc, Martínez, Lm, Val, Jl, Loutfi, G, Olofsson, C, Stattin, El, Westman, L, Wikström, B, Lhagen, Se, Paucar, M, Svenningsson, P, Reza Soltani TW, Höglund, A, Sandström, B, Høsterey Ugander, U, Fredlund, G, Constantinescu, R, Neleborn Lingefjärd, L, Tedr off, J, Esmaeilzadeh, M, Winnberg, E, Pålhagen, S, Svennigsson, P, Riza Soltani TW, Sundblom, J, Johansson, A, Wiklund, L, Ekwall, C, Göller, Ml, Petersén, A, Reimer, J, Widner, H, Stebler, Y, Kaelin, A, Romero, I, Schüpbach, M, Weber, S, Miedzybrodzka, Z, Rae, D, Downie, L, Simpson, S, Summers, F, Ure, A, Jack, R, Matheson, K, Akhtar, S, Crooks, J, Curtis, A, Souza, J, Wright, J, Hayward, B, Sieradzan, K, Barker, Ra, O'Keefe, D, Di Pietro, A, Fisher, K, Hill, S, Mason, S, Swain, R, Valle, N, Guzman, Bisson, J, Busse, M, Butcher, C, Clenaghan, C, Dunnett, S, Handley, O, Hunt, S, Hughes, A, Johnstone, C, Jones, L, Jones, U, Khalil, H, Owen, M, Price, K, Rose, Le, Rosser, A, Porteous, M, Edwards, M, Ho, C, Mcgill, M, Pearson, P, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Miller, J, Ritchie, S, Burrows, L, Fletcher, A, Harding, A, Laver, F, Silva, M, Thomson, A, Rowett, L, Gallantrae, D, Longthorpe, M, Markova, I, Raman, A, Hamer, S, Wild, S, Yarduiman, P, Chu, C, Kraus, A, Yardumian, P, Musgrave, H, Toscano, J, Jamieson, S, Hobson, E, Clayton, C, Dipple, H, Middleton, J, Freire Patino, D, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Laing, H, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Santhouse, A, Patton, M, Peterson, M, Rose, S, Bruno, S, Chu, E, Doherty, K, Haider, S, Hensman, D, Lahiri, N, Lewis, M, Novak, M, Patel, A, Robertson, N, Rosser, E, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Howard, L, Sollom, A, Snowden, J, Thompson, J, Jones, M, Murphy, H, Trender Gerhard, I, Rogers, D, Bek, J, Oughton, E, Johnson, L, Hare, M, Arran, N, Verstraelen, N, Partington Jones, L, Huson, S, Stopford, C, Westmoreland, L, Davidson, J, Morgan, K, Savage, L, Singh, B, Komati, S, Nemeth, Ah, Armstrong, R, Valentine, R, Siuda, G, Harrison, D, Hughes, M, Parkinson, A, Soltysiak, B, Burn, J, Coleman, C, Bandmann, O, Bradbury, A, Gill, P, Fairtlough, H, Fillingham, K, Foustanos, I, Kazoka, M, O'Donovan, K, Taylor, C, Tidswell, K, Quarrell, O., Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), A. A., M, E. v., Duijn, R. A., C, D., Craufurd, H., Rickard, G. B., Landwehrmeyer, R. C., Van, E. J., Giltay, R. E., G., Rinaldi, Carlo, Anna A.M. Huber, Erik van Duijn, Raymund A.C. Roo, David Craufurd, Hugh Rickard, G. Bernhard Landwehrmeyer, Rose C. van der Mast, Erik J. Giltay REGISTRY investigators of the European Huntington's Disease Network. Collaborators: Bachoud-Lévi AC, Bentivoglio AR, Biunno I, Bonelli RM, Burgunder JM, Dunnett SB, Ferreira JJ, Handley OJ, Heiberg A, llmann TI, Landwehrmeyer GB, Levey J, Ramos-Arroyo MA, Nielsen JE, ProKoivisto S, Päivärinta M, Roos RA, Rojo Sebastián A, Tabrizi SJ, Vandenberghe W, Verellen- Dumoulin C, Zaremba J, Uhrova T, Wahlström J, Barth K, Correia-Guedes L, Finisterra AM, Garde MB, Bos R, Betz S, Callaghan J, Fullam R, Ecker D, Nielsen MG, Hvalstedt C, Held C, Koppers K, Laurà M, Horta SM, Descals AM, Mestre T, Minster S, Monza D, Mütze L, Oehmen M, Townhill J, Orth M, Padieu H, Paterski L, Peppa N, Pro Koivisto S, Roedig V, Rialland A, Røren N, Šašinková P, Seliverstov Y, Cubillo PT, Walsem MR, Wright A, da Silva WV, Witjes-Ané MN, Yudina E, Zielonka D, Zielonka E, Zinzi P, Herranhof B, Holl A, Kapfhammer HP, Koppitz M, Magnet M, Otti D, Painold A, Reisinger K, Scheibl M, Hecht K, Lilek S, Müller N, Schöggl H, Ullah J, Brugger F, Hepperger C, Hotter A, Seppi K, Wenning G, Buratti L, Hametner EM, Holas C, Hussl A, Poewe W, Braunwarth EM, Sprenger F, Müller C, Sinadinosa D, Walleczek AM, Ladurner G, Staffen W, Flamez A, Morez V, de Raedt S, Boogaerts A, van Reijen D, Klempíř J, Majerová V, Roth J, Hartikainen P, Hiivola H, Martikainen K, Tuuha K, Ignatius J, Kärppä M, Åman J, Mustonen A, Kajula O, Santala M, Allain P, Guérid MA, Gohier B, Olivier A, Prundean A, Scherer- Gagou C, Verny C, Bost M, Babiloni B, Debruxelles S, Duché C, Goizet C, Lafoucrière D, Jameau L, Spampinato U, De Bruycker C, Cabaret M, Carette AS, Defebvre L, Decorte E, Delval A, Delliaux M, Destee A, Dujardin K, Peter M, Plomhouse L, Sablonnière B, Simonin C, Lemaire MH, Manouvrier S, Thibault-Tanchou S, Vuillaume I, Krystkowiak P, Duru C, Roussel M, Wannepain S, Berrissoul H, Bellonet M, Courtin F, Mantaux B, Fasquel V, Godefroy O, Azulay JP, Fluchère F, Delfini M, Eusebio A, Mundler L, Longato N, Rudolf G, Steinmetz G, Tranchant C, Wagner C, Zimmermann M, Marcel C, Calvas F, Pariente J, Démonet JF, Cheriet S, Kosinski CM, Milkereit E, Probst D, Reetz K, Sass C, Schiefer J, Schlangen C, Werner CJ, Gelderblom H, Priller J, Prüß H, Spruth EJ, Andrich J, Ellrichmann G, Hoffmann R, Kaminski B, Saft C, Stamm C, Lange H, Bosredon C, Maass A, Schmidt S, Storch A, Wolz M, Kohl Z, Winkler J, Capetian P, Lambeck J, Zucker B, Boelmans K, Ganos C, Goerendt I, Hidding U, Lewerenz J, Münchau A, Schmalfeld J, Stubbe L, Zittel S, Diercks G, Dressler D, Gorzolla H, Schrader C, Tacik P, Heinicke W, Longinus B, Bürk K, Möller JC, Rissling I, Mühlau M, Peinemann A, Städtler M, Weindl A, Winkelmann J, Ziegler C, Bohlen S, Hölzner E, Reilmann R, Dose M, Leythaeuser G, Marquard R, Raab T, Schrenk C, Schuierer M, Buck A, Connemann J, Eschenbach C, Landwehrmeyer B, Lezius F, Nepper S, Niess A, Schwenk D, Süßmuth S, Trautmann S, Weydt P, Cormio C, Sciruicchio V, Serpino C, Tommaso M, Capellari S, Cortelli P, Gallassi R, Poda R, Rizzo G, Scaglione C, Bertini E, Ghelli E, Ginestroni A, Massaro F, Mechi C, Paganini M, Piacentini S, Pradella S, Romoli AM, Sorbi S, Abbruzzese G, di Poggio MB, Di Maria E, Ferrandes G, Mandich P, Marchese R, Albanese A, Di Bella D, Di Donato S, Gellera C, Genitrini S, Mariotti C, Nanetti L, Paridi D, Soliveri P, Tomasello C, De Michele G, Di Maio L, Salvatore E, Rinaldi C, Rossi F, Massarelli M, Roca A, Ammendola S, Russo CV, Squitieri F, Elifani F, Maglione V, Di Pardo A, Alberti S, Griguoli A, Amico E, Martino T, Petrollini M, Catalli C, Di Giacopo R, Fasano A, Frontali M, Guidubaldi A, Ialongo T, Jacopini G, Loria G, Piano C, Chiara P, Quaranta D, Romano S, Soleti F, Spadaro M, van Hout MS, van Vugt JP, Weert A, Bolwijn J, Dekker M, Leenders K, Kremer HP, Dumas EM, van den Bogaard SJ, 't Hart EP, van Duijn E, Økland E, Hauge E, Tyvoll H, Frich J, Aaserud O, Wehus R, Bjørgo K, Fannemel M, Gørvell P, Lorentzen E, Koivisto SP, Retterstøl L, Overland T, Stokke B, Sando B, Dziadkiewicz A, Nowak M, Robowski P, Sitek E, Slawek J, Soltan W, Szinwelski M, Blaszcyk M, Boczarska-Jedynak M, Ciach-Wysocka E, Gorzkowska A, Jasinska-Myga B, Opala G, Kłodowska-Duda G, Stompel D, Banaszkiewicz K, Boćwińska D, Szczudlik A, Rudzińska M, Wójcik M, Dec M, Krawczyk M, Jaremek KB, Szczygieł E, Stenwak A, ielewska AW, Bryl A, Ciesielska A, Klimberg A, Marcinkowski J, Sempołowicz J, Samara H, Wiśniewski B, Janik P, Gogol A, Kwiecinski H, Jamrozik Z, Kaminska A, Antczak J, Jachinska K, Rakowicz M, Richter P, Rola R, Ryglewicz D, Sienkiewicz-Jarosz H, Stępniak I, Witkowski G, Zdzienicka E, Sułek A, Krysa W, Zieora-Jakutowicz K, Júlio F, Januário C, Coelho M, Mendes T, Valadas A, Timóteo Â, Costa C, Cavaco S, Damásio J, Loureiro R, Magalhães M, Andrade C, Gago M, Garrett C, Guerra MR, Lima J, Massano J, Meireles J, Herrera CD, Garcia PM, Barrero F, Morales B, Cubo E, Mariscal N, Sánchez J, Alonso-Frech F, Perez MR, Fenollar M, García RG, Quiroga PP, Rivera SV, Villanueva C, Alegre J, Bascuñana M, Caldentey JG, Ventura MF, Ribas GG, Yébenes JG, López-Sendón Moreno JL, García Ruíz PJ, Martínez-Descals A, Artiga MJ, Sánchez V, Guerrero R, Bárcenas AH, Noguera Perea MF, Fortuna L, Martirio M, Torres A, Reinante G, Moreau LV, Barbera MA, Guia DB, Hernanz LC, Catena JL, Sebastián AR, Ferrer PQ, Carruesco GT, Bas J, Busquets N, Calopa M, Elorza MD, Díez-AjaLópez C, Terol SD, Robert MF, Ruíz BG, Casado AG, Martínez IH, Viladrich CM, Càrdenas RP, Roca E, Llesoy JR, Idiago JM, Vergara MR, García SS, Riballo AV, González SG, Guisasola LM, Salvador C, San Martín ES, González M, Gorospe A, Legarda I, Arques PN, Torres Rodríguez MJ, Vives B, Gaston I, Martinez-Jaurrieta MD, Manuel J, Moreno G, Peña JC, Avarvarei LD, Bastida AM, Recio MF, Vergé LR, Sánchez VS, Carrillo F, Cáceres MT, Mir P, Suarez MJ, Bosca M, Burguera JA, Garcia AC, Brugada FC, Martínez LM, Val JL, Loutfi G, Olofsson C, Stattin EL, Westman L, Wikström B, lhagen SE, Paucar M, Svenningsson P, Reza- Soltani TW, Höglund A, Sandström B, Høsterey-Ugander U, Fredlund G, Constantinescu R, Neleborn-Lingefjärd L, Tedr- off J, Esmaeilzadeh M, Winnberg E, Pålhagen S, Svennigsson P, Riza-Soltani TW, Sundblom J, Johansson A, Wiklund L, Ekwall C, Göller ML, Petersén A, Reimer J, Widner H, Stebler Y, Kaelin A, Romero I, Schüpbach M, Weber S, Miedzybrodzka Z, Rae D, Downie L, Simpson S, Summers F, Ure A, Jack R, Matheson K, Akhtar S, Crooks J, Curtis A, Souza J, Rickards H, Wright J, Hayward B, Sieradzan K, Barker RA, O'Keefe D, Di Pietro A, Fisher K, Hill S, Mason S, Swain R, Valle N, Guzman, Bisson J, Busse M, Butcher C, Clenaghan C, Dunnett S, Handley O, Hunt S, Hughes A, Johnstone C, Jones L, Jones U, Khalil H, Owen M, Price K, Rose LE, Rosser A, Porteous M, Edwards M, Ho C, McGill M, Pearson P, Brockie P, Foster J, Johns N, McKenzie S, Rothery J, Thomas G, Yates S, Miller J, Ritchie S, Burrows L, Fletcher A, Harding A, Laver F, Silva M, Thomson A, Rowett L, Gallantrae D, Longthorpe M, Markova I, Raman A, Hamer S, Wild S, Yarduiman P, Chu C, Kraus A, Yardumian P, Musgrave H, Toscano J, Jamieson S, Hobson E, Clayton C, Dipple H, Middleton J, Freire-Patino D, Andrews T, Dougherty A, Kavalier F, Golding C, Laing H, Lashwood A, Robertson D, Ruddy D, Whaite A, Santhouse A, Patton M, Peterson M, Rose S, Bruno S, Chu E, Doherty K, Haider S, Hensman D, Lahiri N, Lewis M, Novak M, Patel A, Robertson N, Rosser E, Tabrizi S, Taylor R, Warner T, Wild E, Craufurd D, Howard L, Sollom A, Snowden J, Thompson J, Jones M, Murphy H, Trender-Gerhard I, Rogers D, Bek J, Oughton E, Johnson L, Hare M, Arran N, Verstraelen N, Partington-Jones L, Huson S, Stopford C, Westmoreland L, Davidson J, Morgan K, Savage L, Singh B, Komati S, Nemeth AH, Armstrong R, Valentine R, Siuda G, Harrison D, Hughes M, Parkinson A, Soltysiak B, Burn J, Coleman C, Bandmann O, Bradbury A, Gill P, Fairtlough H, Fillingham K, Foustanos I, Kazoka M, O'Donovan K, Taylor C, Tidswell K, Quarrell O., Molecular Neuroscience and Ageing Research (MOLAR), Hubers, Aa, van Duijn, E, Roos, Ra, Craufurd, D, Rickards, H, Bernhard Landwehrmeyer, G, van der Mast, Rc, Giltay, Ej, CollaboratorsBachoud Lévi AC, REGISTRY investigators of the European Huntington's Disease N. e. t. w. o. r. k., Bentivoglio, Ar, Biunno, I, Bonelli, Rm, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Handley, Oj, Heiberg, A, Llmann, Ti, Landwehrmeyer, Gb, Levey, J, Ramos Arroyo, Ma, Nielsen, Je, Prokoivisto, S, Päivärinta, M, Rojo Sebastián, A, Tabrizi, Sj, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlström, J, Barth, K, Correia Guedes, L, Finisterra, Am, Garde, Mb, Bos, R, Betz, S, Callaghan, J, Fullam, R, Ecker, D, Nielsen, Mg, Hvalstedt, C, Held, C, Koppers, K, Laurà, M, Horta, Sm, Descals, Am, Mestre, T, Minster, S, Monza, D, Mütze, L, Oehmen, M, Townhill, J, Orth, M, Padieu, H, Paterski, L, Peppa, N, Pro Koivisto, S, Roedig, V, Rialland, A, Røren, N, a??inková, P, Seliverstov, Y, Cubillo, Pt, Walsem, Mr, Wright, A, da Silva, Wv, Witjes Ané, Mn, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Herranhof, B, Holl, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Scheibl, M, Hecht, K, Lilek, S, Müller, N, Schöggl, H, Ullah, J, Brugger, F, Hepperger, C, Hotter, A, Seppi, K, Wenning, G, Buratti, L, Hametner, Em, Holas, C, Hussl, A, Poewe, W, Braunwarth, Em, Sprenger, F, Müller, C, Sinadinosa, D, Walleczek, Am, Ladurner, G, Staffen, W, Flamez, A, Morez, V, de Raedt, S, Boogaerts, A, van Reijen, D, Klempí??, J, Majerová, V, Roth, J, Hartikainen, P, Hiivola, H, Martikainen, K, Tuuha, K, Ignatius, J, Kärppä, M, Åman, J, Mustonen, A, Kajula, O, Santala, M, Allain, P, Guérid, Ma, Gohier, B, Olivier, A, Prundean, A, Scherer Gagou, C, Verny, C, Bost, M, Babiloni, B, Debruxelles, S, Duché, C, Goizet, C, Lafoucrière, D, Jameau, L, Spampinato, U, De Bruycker, C, Cabaret, M, Carette, A, Defebvre, L, Decorte, E, Delval, A, Delliaux, M, Destee, A, Dujardin, K, Peter, M, Plomhouse, L, Sablonnière, B, Simonin, C, Lemaire, Mh, Manouvrier, S, Thibault Tanchou, S, Vuillaume, I, Krystkowiak, P, Duru, C, Roussel, M, Wannepain, S, Berrissoul, H, Bellonet, M, Courtin, F, Mantaux, B, Fasquel, V, Godefroy, O, Azulay, Jp, Fluchère, F, Delfini, M, Eusebio, A, Mundler, L, Longato, N, Rudolf, G, Steinmetz, G, Tranchant, C, Wagner, C, Zimmermann, M, Marcel, C, Calvas, F, Pariente, J, Démonet, Jf, Cheriet, S, Kosinski, Cm, Milkereit, E, Probst, D, Reetz, K, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Gelderblom, H, Priller, J, Prüß, H, Spruth, Ej, Andrich, J, Ellrichmann, G, Hoffmann, R, Kaminski, B, Saft, C, Stamm, C, Lange, H, Bosredon, C, Maass, A, Schmidt, S, Storch, A, Wolz, M, Kohl, Z, Winkler, J, Capetian, P, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Goerendt, I, Hidding, U, Lewerenz, J, Münchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Diercks, G, Dressler, D, Gorzolla, H, Schrader, C, Tacik, P, Heinicke, W, Longinus, B, Bürk, K, Möller, Jc, Rissling, I, Mühlau, M, Peinemann, A, Städtler, M, Weindl, A, Winkelmann, J, Ziegler, C, Bohlen, S, Hölzner, E, Reilmann, R, Dose, M, Leythaeuser, G, Marquard, R, Raab, T, Schrenk, C, Schuierer, M, Buck, A, Connemann, J, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Schwenk, D, Süßmuth, S, Trautmann, S, Weydt, P, Cormio, C, Sciruicchio, V, Serpino, C, Tommaso, M, Capellari, S, Cortelli, P, Gallassi, R, Poda, R, Rizzo, G, Scaglione, C, Bertini, E, Ghelli, E, Ginestroni, A, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, di Poggio, Mb, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Bella, D, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Paridi, D, Soliveri, P, Tomasello, C, DE MICHELE, Giuseppe, Di Maio, L, Salvatore, Elena, Rossi, F, Massarelli, Marco, Roca, Alessandro, Ammendola, S, Russo, Cinzia, Squitieri, F, Elifani, F, Maglione, V, Di Pardo, A, Alberti, S, Griguoli, A, Amico, E, Martino, T, Petrollini, M, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Piano, C, Chiara, P, Quaranta, D, Romano, S, Soleti, F, Spadaro, M, Rinaldi, C, Massarelli, M, Roca, A, Russo, Cv, van Hout, M, van Vugt, Jp, Weert, A, Bolwijn, J, Dekker, M, Leenders, K, Kremer, Hp, Dumas, Em, van den Bogaard, Sj, 't Hart, Ep, Økland, E, Hauge, E, Tyvoll, H, Frich, J, Aaserud, O, Wehus, R, Bjørgo, K, Fannemel, M, Gørvell, P, Lorentzen, E, Koivisto, Sp, Retterstøl, L, Overland, T, Stokke, B, Sando, B, Dziadkiewicz, A, Nowak, M, Robowski, P, Sitek, E, Slawek, J, Soltan, W, Szinwelski, M, Blaszcyk, M, Boczarska Jedynak, M, Ciach Wysocka, E, Gorzkowska, A, Jasinska Myga, B, Opala, G, K??odowska Duda, G, Stompel, D, Banaszkiewicz, K, Bo??wi??ska, D, Szczudlik, A, Rudzi??ska, M, Wójcik, M, Dec, M, Krawczyk, M, Jaremek, Kb, Szczygie??, E, Stenwak, A, Ielewska, Aw, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Sempo??owicz, J, Samara, H, Wi??niewski, B, Janik, P, Gogol, A, Kwiecinski, H, Jamrozik, Z, Kaminska, A, Antczak, J, Jachinska, K, Rakowicz, M, Richter, P, Rola, R, Ryglewicz, D, Sienkiewicz Jarosz, H, St??pniak, I, Witkowski, G, Zdzienicka, E, Su??ek, A, Krysa, W, Zieora Jakutowicz, K, Júlio, F, Januário, C, Coelho, M, Mendes, T, Valadas, A, Timóteo, Â, Costa, C, Cavaco, S, Damásio, J, Loureiro, R, Magalhães, M, Andrade, C, Gago, M, Garrett, C, Guerra, Mr, Lima, J, Massano, J, Meireles, J, Herrera, Cd, Garcia, Pm, Barrero, F, Morales, B, Cubo, E, Mariscal, N, Sánchez, J, Alonso Frech, F, Perez, Mr, Fenollar, M, García, Rg, Quiroga, Pp, Rivera, Sv, Villanueva, C, Alegre, J, Bascuñana, M, Caldentey, Jg, Ventura, Mf, Ribas, Gg, Yébenes, Jg, López Sendón Moreno, Jl, García Ruíz, Pj, Martínez Descals, A, Artiga, Mj, Sánchez, V, Guerrero, R, Bárcenas, Ah, Noguera Perea, Mf, Fortuna, L, Martirio, M, Torres, A, Reinante, G, Moreau, Lv, Barbera, Ma, Guia, Db, Hernanz, Lc, Catena, Jl, Sebastián, Ar, Ferrer, Pq, Carruesco, Gt, Bas, J, Busquets, N, Calopa, M, Elorza, Md, Díez AjaLópez, C, Terol, Sd, Robert, Mf, Ruíz, Bg, Casado, Ag, Martínez, Ih, Viladrich, Cm, Càrdenas, Rp, Roca, E, Llesoy, Jr, Idiago, Jm, Vergara, Mr, García, S, Riballo, Av, González, Sg, Guisasola, Lm, Salvador, C, San Martín, E, González, M, Gorospe, A, Legarda, I, Arques, Pn, Torres Rodríguez, Mj, Vives, B, Gaston, I, Martinez Jaurrieta, Md, Manuel, J, Moreno, G, Peña, Jc, Avarvarei, Ld, Bastida, Am, Recio, Mf, Vergé, Lr, Carrillo, F, Cáceres, Mt, Mir, P, Suarez, Mj, Bosca, M, Burguera, Ja, Garcia, Ac, Brugada, Fc, Martínez, Lm, Val, Jl, Loutfi, G, Olofsson, C, Stattin, El, Westman, L, Wikström, B, Lhagen, Se, Paucar, M, Svenningsson, P, Reza Soltani, Tw, Höglund, A, Sandström, B, Høsterey Ugander, U, Fredlund, G, Constantinescu, R, Neleborn Lingefjärd, L, Tedr off, J, Esmaeilzadeh, M, Winnberg, E, Pålhagen, S, Svennigsson, P, Riza Soltani, Tw, Sundblom, J, Johansson, A, Wiklund, L, Ekwall, C, Göller, Ml, Petersén, A, Reimer, J, Widner, H, Stebler, Y, Kaelin, A, Romero, I, Schüpbach, M, Weber, S, Miedzybrodzka, Z, Rae, D, Downie, L, Simpson, S, Summers, F, Ure, A, Jack, R, Matheson, K, Akhtar, S, Crooks, J, Curtis, A, Souza, J, Wright, J, Hayward, B, Sieradzan, K, Barker, Ra, O'Keefe, D, Di Pietro, A, Fisher, K, Hill, S, Mason, S, Swain, R, Valle, N, Bisson, J, Busse, M, Butcher, C, Clenaghan, C, Dunnett, S, Handley, O, Hunt, S, Hughes, A, Johnstone, C, Jones, L, Jones, U, Khalil, H, Owen, M, Price, K, Rose, Le, Rosser, A, Porteous, M, Edwards, M, Ho, C, Mcgill, M, Pearson, P, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Miller, J, Ritchie, S, Burrows, L, Fletcher, A, Harding, A, Laver, F, Silva, M, Thomson, A, Rowett, L, Gallantrae, D, Longthorpe, M, Markova, I, Raman, A, Hamer, S, Wild, S, Yarduiman, P, Chu, C, Kraus, A, Yardumian, P, Musgrave, H, Toscano, J, Jamieson, S, Hobson, E, Clayton, C, Dipple, H, Middleton, J, Freire Patino, D, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Laing, H, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Santhouse, A, Patton, M, Peterson, M, Rose, S, Bruno, S, Chu, E, Doherty, K, Haider, S, Hensman, D, Lahiri, N, Lewis, M, Novak, M, Patel, A, Robertson, N, Rosser, E, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Howard, L, Sollom, A, Snowden, J, Thompson, J, Jones, M, Murphy, H, Trender Gerhard, I, Rogers, D, Bek, J, Oughton, E, Johnson, L, Hare, M, Arran, N, Verstraelen, N, Partington Jones, L, Huson, S, Stopford, C, Westmoreland, L, Davidson, J, Morgan, K, Savage, L, Singh, B, Komati, S, Nemeth, Ah, Armstrong, R, Valentine, R, Siuda, G, Harrison, D, Hughes, M, Parkinson, A, Soltysiak, B, Burn, J, Coleman, C, Bandmann, O, Bradbury, A, Gill, P, Fairtlough, H, Fillingham, K, Foustanos, I, Kazoka, M, O'Donovan, K, Taylor, C, Tidswell, K, and Quarrell, O.
Subjects: Male, medicine.medical_specialty, Heterozygote, Psychopharmacology, Population, Poison control, psychology/statistics /&/ numerical data, Suicide, Attempted, Suicide prevention, Suicidal Ideation, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 0302 clinical medicine, medicine, Prevalence, Humans, epidemiology, Europe, Psychiatry, education, Suicidal ideation, ComputingMilieux_MISCELLANEOUS, Proportional Hazards Models, Attempted, Psychiatric Status Rating Scales, education.field_of_study, Psychological Tests, Suicide attempt, Psychopathology, Depression, Hazard ratio, Huntington's disease, Odds ratio, Middle Aged, 3. Good health, 030227 psychiatry, Europe, psychology, Male, Middle Aged, Prevalence, Proportional Hazards Models, Psychiatric Status Rating Scales, Psychological Tests, Suicidal Ideation, Suicide, Clinical Psychology, Psychiatry and Mental health, Suicide, Huntington Disease, epidemiology, Female, Heterozygote, Humans, Huntington Disease, Cohort studies, Female, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract: BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
Published: 2013
Full Text: View/download PDF

9. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

Author: Metzger S, Walter C, Riess O, Roos RA, Nielsen JE, Craufurd D, Nguyen HP, REGISTRY Investigators of the European Huntington’s Disease Network:Bachoud Lévi AC, Bentivoglio AR, Biunno I, Bonelli RM, Burgunder JM, Dunnett SB, Ferreira JJ, Handley OJ, Heiberg A, Illmann T, Landwehrmeyer G, Levey J, Ramos Arroyo MA, Nielsen J, Koivisto SP, Päivärinta M, Sebastián AR, Tabrizi S, Vandenberghe W, Verellen Dumoulin C, Zaremba J, Uhrová T, Wahlström J, Barth K, Correia Guedes L, Finisterra AM, Garde MB, Bos R, Betz S, Callaghan J, Fullam R, Ecker D, Nielsen MG, Hvalstedt C, Held C, Koppers K, Laurà M, Horta SM, Descals AM, Díaz MF, Mestre T, Minster S, Monza D, Mütze L, Oehmen M, Townhill J, Orth M, Padieu H, Paterski L, Peppa N, Roedig V, Rialland A, Røren N, Šašinková P, Seliverstov Y, Cubillo PT, van Walsem MR, Wright A, Silva WV, Witjes Anné MN, Yudina E, Zielonka D, Zielonka E, Zinzi P, Herranhof B, Holl A, Kapfhammer HP, Koppitz M, Magnet M, Otti D, Painold A, Reisinger K, Scheibl M, Hecht K, Lilek S, Müller N, Schöggl H, Ullah J, Ribaï P, Boogaerts A, van Reijen D, Klempíř J, Majerová V, Roth J, Hjermind L, Jacobsen O, Vinthev Jensen T, Larsen IU, Stockholm J, Hiivola H, Martikainen K, Tuuha K, Ignatius J, Kärppä M, Åman J, Mustonen A, Kajula O, Santala M, Allain P, Guérid MA, Gohier B, Olivier A, Prundean A, Scherer Gagou C, Verny C, Bost M, Babiloni B, Debruxelles S, Duché C, Goizet C, Lafoucrière D, Jameau L, Spampinato U, De Bruycker C, Cabaret M, Carette AS, Defebvre L, Decorte E, Delval A, Delliaux M, Destee A, Dujardin K, Peter M, Plomhouse L, Sablonnière B, Simonin C, Lemaire MH, Manouvrier S, Thibault Tanchou S, Vuillaume I, Krystkowiak P, Duru C, Roussel M, Wannepain S, Berrissoul H, Bellonet M, Courtin F, Mantaux B, Fasquel V, Godefroy O, Azulay JP, Fluchère F, Delfini M, Eusebio A, Mundler L, Longato N, Rudolf G, Steinmetz G, Tranchant C, Wagner C, Zimmermann MA, Marcel C, Andrich J, Ellrichmann G, Hoffmann R, Kaminski B, Saft C, Stamm C, Boelmans K, Ganos C, Goerendt I, Hidding U, Lewerenz J, Münchau A, Schmalfeld J, Stubbe L, Zittel S, Bürk K, Möller JC, Rissling I, Cormio C, Sciruicchio V, Serpino C, de Tommaso M, CAPELLARI, SABINA, CORTELLI, PIETRO, Gallassi R, PODA, ROBERTO, RIZZO, GIOVANNI, Scaglione C, Abbruzzese G, di Poggio MB, Di Maria E, Ferrandes G, Mandich P, Marchese R, Albanese A, Di Bella D, Di Donato S, Gellera C, Genitrini S, Mariotti C, Nanetti L, Paridi D, Soliveri P, Tomasello C, Squitieri F, Elifani F, Maglione V, Di Pardo A, Alberti S, Griguoli A, Amico E, Martino T, Petrollini M, Catalli C, Di Giacopo R, Fasano A, Frontali M, Guidubaldi A, Ialongo T, Jacopini G, Loria G, Piano C, Chiara P, Quaranta D, Romano S, Soleti F, Spadaro M, van Hout MS, van Vugt JP, de Weert A, Bolwijn JJ, Dekker M, Leenders KL, Dumas EM, van den Bogaard SJ, 't Hart EP, van Duijn E, Kremer B, Verstappen CC, Blinkenberg EØ, Hauge E, Tyvoll H, Frich J, Aaserud O, Wehus R, Bjørgo K, Fannemel M, Gørvell P, Lorentzen E, Retterstøl L, Overland T, Stokke B, Bjørnevoll I, Sando SB, Dziadkiewicz A, Nowak M, Robowski P, Sitek E, Slawek J, Soltan W, Szinwelski M, Blaszcyk M, Boczarska Jedynak M, Ciach Wysocka E, Gorzkowska A, Jasinska Myga B, Opala G, Kłodowska Duda G, Stompel D, Banaszkiewicz K, Boćwińska D, Szczudlik A, Rudzinska M, Wójcik M, Dec M, Krawczyk M, Bojakowska Jaremek K, Szczygieł E, Stenwak A, Wasielewska A, Bryl A, Ciesielska A, Klimberg A, Marcinkowski J, Sempołowicz J, Samara H, Wiśniewski B, Janik P, Gogol A, Kwiecinski H, Jamrozik Z, Kaminska A, Antczak J, Jachinska K, Rakowicz M, Richter P, Rola R, Ryglewicz D, Sienkiewicz Jarosz H, Stępniak I, Witkowski G, Zdzienicka E, Sułek A, Krysa W, Stepniak I, Zieora Jakutowicz K, Júlio F, Januário C, Coelho M, Mendes T, Valadas A, Andrade C, Gago M, Garrett C, Guerra MR, Lima J, Massano J, Meireles J, Herrera CD, Garcia PM, Barrero F, Morales B, Cubo E, Mariscal N, Sánchez J, Alonso Frech F, Perez MR, Fenollar M, García RG, Pin Quiroga P, Vázquez Rivera S, Villanueva C, Alegre J, Bascuñana M, Caldentey JG, Ventura MF, Ribas GG, de Yébenes JG, Moreno JL, Ruíz PJ, Martínez Descals A, Artiga MJ, Sánchez V, Guerrero R, Bárcenas AH, Perea MF, Fortuna L, Torres MM, Reinante G, Moreau LV, Barbera MA, Guia DB, Hernanz LC, Catena JL, Ferrer PQ, Carruesco GT, Bas J, Busquets N, Calopa M, Elorza MD, López CD, Durán Sindreu Terol S, Robert MF, Ruíz BG, Casado AG, Martínez IH, Viladrich CM, Cárdenas RP, Roca E, Llesoy JR, Idiago JM, Vergara MR, García SS, Riballo AV, González SG, Guisasola LM, Salvador C, Martín ES, González M, Gorospe A, Legarda I, Arques PN, Rodríguez MJ, Vives B, Gaston I, Martinez Jaurrieta MD, Moreno JM, Peña JC, Avarvarei LD, Bastida AM, Recio MF, Vergé LR, Sánchez VS, Carrillo F, Cáceres MT, Mir P, Suarez MJ, Loutfi G, Olofsson C, Stattin EL, Westman L, Wikström B, Pålhagen SE, Paucar M, Svenningsson P, Reza Soltani TW, Höglund A, Sandström B, Høsterey Ugander U, Fredlund G, Constantinescu R, Neleborn Lingefjärd L, Stebler Y, Kaelin A, Romero I, Schüpbach M, Zaugg SW, Miedzybrodzka Z, Rae D, Downie L, Simpson S, Summers F, Ure A, Jack R, Matheson K, Akhtar S, Crooks J, Curtis A, de Souza J, Rickards H, Wright J, Barker RA, O' Keefe D, Di Pietro A, Fisher K, Goodman A, Hill S, Mason S, Swain R, Guzman NV, Bisson J, Busse M, Butcher C, Clenaghan C, Dunnett S, Handley O, Hunt S, Hughes A, Johnstone C, Jones L, Jones U, Khalil H, Owen M, Price K, Rose LE, Rosser A, Porteous M, Edwards M, Ho C, McGill M, Pearson P, Brockie P, Foster J, Johns N, McKenzie S, Rothery J, Thomas G, Yates S, Burrows L, Fletcher A, Harding A, Laver F, Silva M, Thomson A, Rowett L, Gallantrae D, Longthorpe M, Markova I, Raman A, Hamer S, Yarduiman P, Chu C, Kraus A, Wild S, Musgrave H, Toscano J, Jamieson S, Hobson E, Clayton C, Dipple H, Middleton J, Freire Patino D, Andrews T, Dougherty A, Kavalier F, Golding C, Laing H, Lashwood A, Robertson D, Ruddy D, Whaite A, Santhouse A, Patton M, Peterson M, Rose S, Bruno S, Chu E, Doherty K, Haider S, Hensman D, Lahiri N, Lewis M, Novak M, Patel A, Robertson N, Rosser E, Taylor R, Warner T, Wild E, Howard L, Sollom A, Snowden J, Thompson J, Jones M, Murphy H, Trender Gerhard I, Rogers D, Bek J, Oughton E, Johnson L, Hare M, Arran N, Verstraelen N, Partington Jones L, Huson S, Stopford C, Westmoreland L, Davidson J, Morgan K, Savage L, Singh B, Komati S, Nemeth AH, Armstrong R, Valentine R, Siuda G, Harrison D, Hughes M, Parkinson A, Soltysiak B, Bandmann O, Bradbury A, Gill P, Fairtlough H, Fillingham K, Foustanos I, Kazoka M, O' Donovan K, Taylor C, Tidswell K, Quarrell O, Metzger S, Walter C, Riess O, Roos RA, Nielsen JE, Craufurd D, Nguyen HP, REGISTRY Investigators of the European Huntington’s Disease Network:Bachoud-Lévi AC, Bentivoglio AR, Biunno I, Bonelli RM, Burgunder JM, Dunnett SB, Ferreira JJ, Handley OJ, Heiberg A, Illmann T, Landwehrmeyer G, Levey J, Ramos-Arroyo MA, Nielsen J, Koivisto SP, Päivärinta M, Sebastián AR, Tabrizi S, Vandenberghe W, Verellen-Dumoulin C, Zaremba J, Uhrová T, Wahlström J, Barth K, Correia-Guedes L, Finisterra AM, Garde MB, Bos R, Betz S, Callaghan J, Fullam R, Ecker D, Nielsen MG, Hvalstedt C, Held C, Koppers K, Laurà M, Horta SM, Descals AM, Díaz MF, Mestre T, Minster S, Monza D, Mütze L, Oehmen M, Townhill J, Orth M, Padieu H, Paterski L, Peppa N, Roedig V, Rialland A, Røren N, Šašinková P, Seliverstov Y, Cubillo PT, van Walsem MR, Wright A, Silva WV, Witjes-Anné MN, Yudina E, Zielonka D, Zielonka E, Zinzi P, Herranhof B, Holl A, Kapfhammer HP, Koppitz M, Magnet M, Otti D, Painold A, Reisinger K, Scheibl M, Hecht K, Lilek S, Müller N, Schöggl H, Ullah J, Ribaï P, Boogaerts A, van Reijen D, Klempíř J, Majerová V, Roth J, Hjermind L, Jacobsen O, Vinthev-Jensen T, Larsen IU, Stockholm J, Hiivola H, Martikainen K, Tuuha K, Ignatius J, Kärppä M, Åman J, Mustonen A, Kajula O, Santala M, Allain P, Guérid MA, Gohier B, Olivier A, Prundean A, Scherer-Gagou C, Verny C, Bost M, Babiloni B, Debruxelles S, Duché C, Goizet C, Lafoucrière D, Jameau L, Spampinato U, De Bruycker C, Cabaret M, Carette AS, Defebvre L, Decorte E, Delval A, Delliaux M, Destee A, Dujardin K, Peter M, Plomhouse L, Sablonnière B, Simonin C, Lemaire MH, Manouvrier S, Thibault-Tanchou S, Vuillaume I, Krystkowiak P, Duru C, Roussel M, Wannepain S, Berrissoul H, Bellonet M, Courtin F, Mantaux B, Fasquel V, Godefroy O, Azulay JP, Fluchère F, Delfini M, Eusebio A, Mundler L, Longato N, Rudolf G, Steinmetz G, Tranchant C, Wagner C, Zimmermann MA, Marcel C, Andrich J, Ellrichmann G, Hoffmann R, Kaminski B, Saft C, Stamm C, Boelmans K, Ganos C, Goerendt I, Hidding U, Lewerenz J, Münchau A, Schmalfeld J, Stubbe L, Zittel S, Bürk K, Möller JC, Rissling I, Cormio C, Sciruicchio V, Serpino C, de Tommaso M, Capellari S, Cortelli P, Gallassi R, Poda R, Rizzo G, Scaglione C, Abbruzzese G, di Poggio MB, Di Maria E, Ferrandes G, Mandich P, Marchese R, Albanese A, Di Bella D, Di Donato S, Gellera C, Genitrini S, Mariotti C, Nanetti L, Paridi D, Soliveri P, Tomasello C, Squitieri F, Elifani F, Maglione V, Di Pardo A, Alberti S, Griguoli A, Amico E, Martino T, Petrollini M, Catalli C, Di Giacopo R, Fasano A, Frontali M, Guidubaldi A, Ialongo T, Jacopini G, Loria G, Piano C, Chiara P, Quaranta D, Romano S, Soleti F, Spadaro M, van Hout MS, van Vugt JP, de Weert A, Bolwijn JJ, Dekker M, Leenders KL, Dumas EM, van den Bogaard SJ, 't Hart EP, van Duijn E, Kremer B, Verstappen CC, Blinkenberg EØ, Hauge E, Tyvoll H, Frich J, Aaserud O, Wehus R, Bjørgo K, Fannemel M, Gørvell P, Lorentzen E, Retterstøl L, Overland T, Stokke B, Bjørnevoll I, Sando SB, Dziadkiewicz A, Nowak M, Robowski P, Sitek E, Slawek J, Soltan W, Szinwelski M, Blaszcyk M, Boczarska-Jedynak M, Ciach-Wysocka E, Gorzkowska A, Jasinska-Myga B, Opala G, Kłodowska-Duda G, Stompel D, Banaszkiewicz K, Boćwińska D, Szczudlik A, Rudzinska M, Wójcik M, Dec M, Krawczyk M, Bojakowska-Jaremek K, Szczygieł E, Stenwak A, Wasielewska A, Bryl A, Ciesielska A, Klimberg A, Marcinkowski J, Sempołowicz J, Samara H, Wiśniewski B, Janik P, Gogol A, Kwiecinski H, Jamrozik Z, Kaminska A, Antczak J, Jachinska K, Rakowicz M, Richter P, Rola R, Ryglewicz D, Sienkiewicz-Jarosz H, Stępniak I, Witkowski G, Zdzienicka E, Sułek A, Krysa W, Stepniak I, Zieora-Jakutowicz K, Júlio F, Januário C, Coelho M, Mendes T, Valadas A, Andrade C, Gago M, Garrett C, Guerra MR, Lima J, Massano J, Meireles J, Herrera CD, Garcia PM, Barrero F, Morales B, Cubo E, Mariscal N, Sánchez J, Alonso-Frech F, Perez MR, Fenollar M, García RG, Pin Quiroga P, Vázquez Rivera S, Villanueva C, Alegre J, Bascuñana M, Caldentey JG, Ventura MF, Ribas GG, de Yébenes JG, Moreno JL, Ruíz PJ, Martínez-Descals A, Artiga MJ, Sánchez V, Guerrero R, Bárcenas AH, Perea MF, Fortuna L, Torres MM, Reinante G, Moreau LV, Barbera MA, Guia DB, Hernanz LC, Catena JL, Ferrer PQ, Carruesco GT, Bas J, Busquets N, Calopa M, Elorza MD, López CD, Durán-Sindreu Terol S, Robert MF, Ruíz BG, Casado AG, Martínez IH, Viladrich CM, Cárdenas RP, Roca E, Llesoy JR, Idiago JM, Vergara MR, García SS, Riballo AV, González SG, Guisasola LM, Salvador C, Martín ES, González M, Gorospe A, Legarda I, Arques PN, Rodríguez MJ, Vives B, Gaston I, Martinez-Jaurrieta MD, Moreno JM, Peña JC, Avarvarei LD, Bastida AM, Recio MF, Vergé LR, Sánchez VS, Carrillo F, Cáceres MT, Mir P, Suarez MJ, Loutfi G, Olofsson C, Stattin EL, Westman L, Wikström B, Pålhagen SE, Paucar M, Svenningsson P, Reza-Soltani TW, Höglund A, Sandström B, Høsterey-Ugander U, Fredlund G, Constantinescu R, Neleborn-Lingefjärd L, Stebler Y, Kaelin A, Romero I, Schüpbach M, Zaugg SW, Miedzybrodzka Z, Rae D, Downie L, Simpson S, Summers F, Ure A, Jack R, Matheson K, Akhtar S, Crooks J, Curtis A, de Souza J, Rickards H, Wright J, Barker RA, O' Keefe D, Di Pietro A, Fisher K, Goodman A, Hill S, Mason S, Swain R, Guzman NV, Bisson J, Busse M, Butcher C, Clenaghan C, Dunnett S, Handley O, Hunt S, Hughes A, Johnstone C, Jones L, Jones U, Khalil H, Owen M, Price K, Rose LE, Rosser A, Porteous M, Edwards M, Ho C, McGill M, Pearson P, Brockie P, Foster J, Johns N, McKenzie S, Rothery J, Thomas G, Yates S, Burrows L, Fletcher A, Harding A, Laver F, Silva M, Thomson A, Rowett L, Gallantrae D, Longthorpe M, Markova I, Raman A, Hamer S, Yarduiman P, Chu C, Kraus A, Wild S, Musgrave H, Toscano J, Jamieson S, Hobson E, Clayton C, Dipple H, Middleton J, Freire-Patino D, Andrews T, Dougherty A, Kavalier F, Golding C, Laing H, Lashwood A, Robertson D, Ruddy D, Whaite A, Santhouse A, Patton M, Peterson M, Rose S, Bruno S, Chu E, Doherty K, Haider S, Hensman D, Lahiri N, Lewis M, Novak M, Patel A, Robertson N, Rosser E, Taylor R, Warner T, Wild E, Howard L, Sollom A, Snowden J, Thompson J, Jones M, Murphy H, Trender-Gerhard I, Rogers D, Bek J, Oughton E, Johnson L, Hare M, Arran N, Verstraelen N, Partington-Jones L, Huson S, Stopford C, Westmoreland L, Davidson J, Morgan K, Savage L, Singh B, Komati S, Nemeth AH, Armstrong R, Valentine R, Siuda G, Harrison D, Hughes M, Parkinson A, Soltysiak B, Bandmann O, Bradbury A, Gill P, Fairtlough H, Fillingham K, Foustanos I, Kazoka M, O' Donovan K, Taylor C, Tidswell K, and Quarrell O
Subjects: Adult, Adolescent, Genotype, Huntington, Ubiquitin-Activating Enzymes, Autophagy-Related Protein 7, Polymorphism, Single Nucleotide, Cohort Studies, Young Adult, Gene Frequency, V471A polymorphism, Genetics, Autophagy, Humans, Age of Onset, Child, Biology, Genetic Association Studies, Aged, Clinical Genetics, Evolutionary Biology, Computational Biology, Human Genetics, Middle Aged, Huntington Disease, Neurology, Italy, Autosomal Dominant, Child, Preschool, Genetic Polymorphism, Medicine, Population Genetics, gene ATG7, Research Article
Abstract: The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the "REGISTRY" cohort from the European Huntington Disease Network (EHDN). In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients). In these Italian patients, the polymorphism is associated with a 6-years earlier disease onset and thus seems to have an aggravating effect. We could specify the role of ATG7 as a genetic modifier for HD particularly in the Italian population. This result affirms the modifying influence of the autophagic pathway on the course of HD, but also suggests population-specific modifying mechanisms in HD pathogenesis.
Published: 2013

10. Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY

Author: Orth, M, Handley, Oj, Schwenke, C, Dunnett, S, Wild, Ej, Tabrizi, Sj, Landwehrmeyer, Gb, Bachoud Lévi AC, Bentivoglio, Ar, Biunno, I, Bonelli, R, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Giuliano, J, Heiberg, A, Illmann, T, van Kammen, D, Landwehrmeye, Gb, Levey, J, Nielsen, Je, Päivärinta, M, Roos, Ra, Sebastián, Ar, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlström, J, Wallner, M, Barth, K, Guedes, Lc, Finisterra, Am, Garde, Mb, Bos, R, Burg, S, Ecker, D, Held, C, Koppers, K, Laurà, M, Descals, Am, Mclean, T, Mestre, T, Minster, S, Monza, D, Townhill, J, Padieu, H, Paterski, L, Peppa, N, Koivisto, Sp, Rialland, A, Røren, N, Sasinková, P, Cubillo, Pt, Tritsch, C, van Walsem MR, Witjes Ané MN, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Bonelli, Rm, Herranhof, B, Holl, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Scheibl, M, Hecht, K, Lilek, S, Müller, N, Schöggl, H, Ullah, J, Brugger, F, Hepperger, C, Hotter, A, Mahlknecht, P, Nocker, M, Seppi, K, Wenning, G, Buratti, L, Hametner, Em, Holas, C, Hussl, A, Mair, K, Poewe, W, Wolf, E, Zangerl, A, Braunwarth, Em, Sinadinosa, D, Walleczek, Am, Ladurner, G, Staffen, W, Ribaï, P, Flamez, A, Morez, V, de Raedt, S, Boogaerts, A, van Reijen, D, Klempíř, J, Kucharík, M, Roth, J, Šenkárová, Z, Hasholt, L, Hjermind, Le, Jakobsen, O, Nørremølle, A, Sørensen, Sa, Stokholm, J, Nielsen, J, Hiivola, H, Martikainen, K, Tuuha, K, Peippo, M, Sipponen, M, Ignatius, J, Kärppä, M, Åman, J, Santala, M, Allain, P, Guérid, Ma, Gohier, B, Olivier, A, Prundean, A, Scherer Gagou, C, Verny, C, Babiloni, B, Debruxelles, S, Goizet, C, Lafoucrière, D, De Bruycker, C, Carette, As, Decorte, E, Delval, A, Delliaux, M, Dujardin, K, Peter, M, Plomhouse, L, Simonin, C, Thibault Tanchou, S, Bellonet, M, Duru, C, Krystkowiak, P, Roussel, M, Wannepain, S, Azulay, Jp, Chabot, C, Delphini, M, Eusebio, A, Grosjean, H, Mundler, L, Nowak, M, Rudolf, G, Steinmetz, G, Tranchant, C, Wagner, C, Zimmermann, Ma, Calvas, F, Cheriet, S, Démonet, Jf, Galitzky, M, Kosinski, Cm, Milkereit, E, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Gelderblom, H, Priller, J, Prüss, H, Spruth, Ej, Andrich, J, Hoffmann, R, Kraus, Ph, Muth, S, Prehn, C, Saft, C, Salmen, S, Stamm, C, Steiner, T, Strassburger, K, Lange, H, Friedrich, A, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Hidding, U, Lewerenz, J, Münchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Diercks, G, Gorzolla, H, Schrader, C, Heinicke, W, Ribbat, M, Longinus, B, Bürk, K, Möller, Jc, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bechtel, N, Beckmann, H, Bohlen, S, Hölzner, E, Reilmann, R, Rohm, S, Rumpf, S, Schepers, S, Beister, A, Dose, M, Hammer, K, Kieni, J, Leythaeuser, G, Marquard, R, Raab, T, Richter, S, Selimbegovic Turkovic, A, Schrenk, C, Schuierer, M, Wiedemann, A, Buck, A, Connemann, J, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Süssmuth, S, Trautmann, S, Weydt, P, Cormio, C, Difruscolo, O, Sciruicchio, V, Serpino, C, de Tommaso, M, Capellari, S, Cortelli, P, Gallassi, R, Poda, R, Rizzo, G, Scaglione, C, Bertini, E, Ghelli, E, Ginestroni, A, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, di Poggio MB, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Bella, D, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Paridi, D, Soliveri, P, Tomasello, C, De Michele, G, Di Maio, L, Rinaldi, C, Russo, Cv, Salvatore, E, Tucci, T, Cannella, M, Codella, V, De Gregorio, F, De Nicola, N, Martino, T, Simonelli, M, Squitieri, F, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Modoni, A, Piano, C, Chiara, P, Quaranta, D, Romano, Silvia, Soleti, F, Spadaro, M, van Hout MS, van Vugt JP, de Weert AM, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom JC, Dumas, Em, Jurgens, Ck, van den Bogaard SJ, 't Hart EP, Kremer, B, Verstappen, Cc, Frich, J, Wehus, R, Aaserud, O, Borgerød, N, Bjørgo, K, Fannemel, M, Gørvell, P, Pro Koivisto, S, Retterstøl, L, Overland, T, Stokke, B, Bjørnevoll, I, Sando, Sb, Blinkenberg, Eø, Hauge, E, Tyvoll, H, Sitek, E, Slawek, J, Soltan, W, Boczarska Jedynak, M, Jasinska Myga, B, Opala, G, Kłodowska Duda, G, Banaszkiewicz, K, Szczudlik, A, Rudzińska, M, Wójcik, M, Dec, M, Krawczyk, M, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Sempołowicz, J, Samara, H, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Jachinska, K, Rakowicz, M, Richter, P, Ryglewicz, D, Witkowski, G, Zdzienicka, E, Sułek, A, Krysa, W, Júlio, F, Januário, C, Guedes, L, Coelho, M, Mendes, T, Valadas, A, Timóteo, Â, Costa, C, Vale, J, Cavaco, S, Damásio, J, Magalhães, M, Gago, M, Garrett, C, Guerra, Mr, Solis, P, Herrera, Cd, Garcia, Pm, Barrero, F, Morales, B, Cubo, E, Mariscal, N, Alonso Frech, F, Perez, Mr, Fenollar, M, García, Rg, Quiroga, Pp, Rivera, Sv, Villanueva, C, Bascuñana, M, Ventura, Mf, Ribas, Gg, de Yébenes JG, Moreno, Jl, Ruíz, Pj, Martínez Descals, A, Artiga, Mj, Sánchez, V, Perea, Mf, Lorenza, F, Torres, Mm, Reinante, G, Moreau, Lv, Barbera, Ma, Guia, Db, Hernanz, Lc, Catena, Jl, Ferrer, Pq, Carruesco, Gt, Bas, J, Busquets, N, Calopa, M, Buongiorno, Mt, Muñoz, E, Elorza, Md, López, Cd, Terol, Sd, Robert, Mf, Ruíz, Bg, Casado, Ag, Martínez, Ih, Viladrich, Cm, Càrdenas R, Pons i., Roca, E, Llesoy, Jr, Idiago, Jm, Vergara, Mr, García, Ss, Villa Riballo, A, González, Sg, Guisasola, Lm, Salvador, C, San Martín ES, Gorospe, A, Legarda, I, Arques, Pn, Rodríguez, Mj, Vives, B, Gaston, I, Ramos Arroyo MA, Moreno, Jm, Peña, Jc, Avarvarei, Ld, Bastida, Am, Recio, Mf, Vergé, Lr, Sánchez, Vs, Carrillo, F, Cáceres, Mt, Mir, P, Suarez, Mj, Bosca, M, Burguera, Ja, Garcia, Ac, Martínez, Lm, del Val JL, Loutfi, G, Olofsson, C, Stattin, El, Westman, L, Wikström, B, Höglund, A, Pålhagen, Se, Paucar, M, Sandström, B, Soltani, R, Svenningsson, P, Reza Soltani TW, Constantinescu, R, Fredlund, G, Høsterey Ugander, U, Neleborn Lingefjärd, L, Esmaeilzadeh, M, Tedroff, J, Winnberg, E, Björn, Y, Ekwall, C, Gøller, Ml, Johansson, A, Wiklund, L, Petersen, Å, Reimer, J, Widner, H, Burgunder, Y, Stebler, Y, Kaelin, A, Romero, I, Schüpbach, M, Zaugg, Sw, Jack, R, Matheson, K, Miedzybrodzka, Z, Rae, D, Simpson, S, Summers, F, Ure, A, Crooks, J, Curtis, A, de Souza Keylock, J, Rickards, H, Wright, J, Hayward, B, Sieradzan, K, Wright, A, Barker, Ra, Di Pietro, A, Fisher, K, Goodman, A, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Clenaghan, C, Ellison Rose, L, Handley, O, Hunt, S, Price, K, Rosser, A, Edwards, M, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Smith, P, Zeman, A, Causley, A, Harrower, T, Howcroft, D, Lambord, N, Rankin, J, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Miller, J, Ritchie, S, Burrows, L, Fletcher, A, Harding, A, Laver, F, Silva, M, Thomson, A, Burns, P, Chu, C, Evans, C, Hamer, S, Markova, I, Raman, A, Barnes, K, Hobson, E, Jamieson, S, Thomson, J, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Clapton, J, Grant, D, Hallam, C, Middleton, J, Murch, A, Patino, D, Bate, L, Pate, L, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Patton, M, Peterson, M, Rose, S, Bruno, S, Chu, E, Doherty, K, Henley, S, Lahiri, N, Novak, M, Patel, A, Read, J, Rosser, E, Say, M, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Callaghan, J, Craufurd, D, Fullam, R, Howard, L, Huson, S, Oughton, E, Partington Jones, L, Snowden, J, Sollom, A, Stopford, C, Thompson, J, Trender Gerhad, I, Verstraelen, N, Westmoreland, L, Nemeth, Ah, Siuda, G, Harrison, D, Hughes, M, Parkinson, A, Soltysiak, B, Burn, J, Coleman, C, Majeed, T, Verstraelen Ritchie, N, Bandmann, O, Bradbury, A, Gill, P, Fairtlough, H, Fillingham, K, Foustanos, I, O'Donovan, K, Tidswell, K, Quarrell, O., Orth, M, European Huntington's Disease, Network, Handley, Oj, Schwenke, C, Dunnett, S, Wild, Ej, Tabrizi, Sj, Bachoud Lévi AC, Landwehrmeyer G. B., Bentivoglio, Ar, Biunno, I, Bonelli, R, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Giuliano, J, Heiberg, A, Illmann, T, van Kammen, D, Landwehrmeye, Gb, Levey, J, Nielsen, Je, Päivärinta, M, Roos, Ra, Sebastián, Ar, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlström, J, Wallner, M, Barth, K, Guedes, Lc, Finisterra, Am, Garde, Mb, Bos, R, Burg, S, Ecker, D, Held, C, Koppers, K, Laurà, M, Descals, Am, Mclean, T, Mestre, T, Minster, S, Monza, D, Townhill, J, Padieu, H, Paterski, L, Peppa, N, Koivisto, Sp, Rialland, A, Røren, N, Sasinková, P, Cubillo, Pt, Tritsch, C, van Walsem, Mr, Witjes Ané, Mn, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Bonelli, Rm, Herranhof, B, Holl, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Scheibl, M, Hecht, K, Lilek, S, Müller, N, Schöggl, H, Ullah, J, Brugger, F, Hepperger, C, Hotter, A, Mahlknecht, P, Nocker, M, Seppi, K, Wenning, G, Buratti, L, Hametner, Em, Holas, C, Hussl, A, Mair, K, Poewe, W, Wolf, E, Zangerl, A, Braunwarth, Em, Sinadinosa, D, Walleczek, Am, Ladurner, G, Staffen, W, Ribaï, P, Flamez, A, Morez, V, de Raedt, S, Boogaerts, A, van Reijen, D, Klempíř, J, Kucharík, M, Roth, J, Šenkárová, Z, Hasholt, L, Hjermind, Le, Jakobsen, O, Nørremølle, A, Sørensen, Sa, Stokholm, J, Nielsen, J, Hiivola, H, Martikainen, K, Tuuha, K, Peippo, M, Sipponen, M, Ignatius, J, Kärppä, M, Åman, J, Santala, M, Allain, P, Guérid, Ma, Gohier, B, Olivier, A, Prundean, A, Scherer Gagou, C, Verny, C, Babiloni, B, Debruxelles, S, Goizet, C, Lafoucrière, D, De Bruycker, C, Carette, A, Decorte, E, Delval, A, Delliaux, M, Dujardin, K, Peter, M, Plomhouse, L, Simonin, C, Thibault Tanchou, S, Bellonet, M, Duru, C, Krystkowiak, P, Roussel, M, Wannepain, S, Azulay, Jp, Chabot, C, Delphini, M, Eusebio, A, Grosjean, H, Mundler, L, Nowak, M, Rudolf, G, Steinmetz, G, Tranchant, C, Wagner, C, Zimmermann, Ma, Calvas, F, Cheriet, S, Démonet, Jf, Galitzky, M, Kosinski, Cm, Milkereit, E, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Gelderblom, H, Priller, J, Prüss, H, Spruth, Ej, Andrich, J, Hoffmann, R, Kraus, Ph, Muth, S, Prehn, C, Saft, C, Salmen, S, Stamm, C, Steiner, T, Strassburger, K, Lange, H, Friedrich, A, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Hidding, U, Lewerenz, J, Münchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Diercks, G, Gorzolla, H, Schrader, C, Heinicke, W, Ribbat, M, Longinus, B, Bürk, K, Möller, Jc, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bechtel, N, Beckmann, H, Bohlen, S, Hölzner, E, Reilmann, R, Rohm, S, Rumpf, S, Schepers, S, Beister, A, Dose, M, Hammer, K, Kieni, J, Leythaeuser, G, Marquard, R, Raab, T, Richter, S, Selimbegovic Turkovic, A, Schrenk, C, Schuierer, M, Wiedemann, A, Buck, A, Connemann, J, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Süssmuth, S, Trautmann, S, Weydt, P, Cormio, C, Difruscolo, O, Sciruicchio, V, Serpino, C, de Tommaso, M, Capellari, S, Cortelli, P, Gallassi, R, Poda, R, Rizzo, G, Scaglione, C, Bertini, E, Ghelli, E, Ginestroni, A, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, di Poggio, Mb, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Bella, D, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Paridi, D, Soliveri, P, Tomasello, C, DE MICHELE, Giuseppe, Di Maio, L, Rinaldi, Carlo, Russo, Cv, Salvatore, Elena, Tucci, T, Cannella, M, Codella, V, De Gregorio, F, De Nicola, N, Martino, T, Simonelli, M, Squitieri, F, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Modoni, A, Piano, C, Chiara, P, Quaranta, D, Romano, S, Soleti, F, Spadaro, M, van Hout, M, van Vugt, Jp, de Weert, Am, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom, Jc, Dumas, Em, Jurgens, Ck, van den Bogaard, Sj, 't Hart, Ep, Kremer, B, Verstappen, Cc, Frich, J, Wehus, R, Aaserud, O, Borgerød, N, Bjørgo, K, Fannemel, M, Gørvell, P, Pro Koivisto, S, Retterstøl, L, Overland, T, Stokke, B, Bjørnevoll, I, Sando, Sb, Blinkenberg, Eø, Hauge, E, Tyvoll, H, Sitek, E, Slawek, J, Soltan, W, Boczarska Jedynak, M, Jasinska Myga, B, Opala, G, Kłodowska Duda, G, Banaszkiewicz, K, Szczudlik, A, Rudzińska, M, Wójcik, M, Dec, M, Krawczyk, M, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Sempołowicz, J, Samara, H, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Jachinska, K, Rakowicz, M, Richter, P, Ryglewicz, D, Witkowski, G, Zdzienicka, E, Sułek, A, Krysa, W, Júlio, F, Januário, C, Guedes, L, Coelho, M, Mendes, T, Valadas, A, Timóteo, Â, Costa, C, Vale, J, Cavaco, S, Damásio, J, Magalhães, M, Gago, M, Garrett, C, Guerra, Mr, Solis, P, Herrera, Cd, Garcia, Pm, Barrero, F, Morales, B, Cubo, E, Mariscal, N, Alonso Frech, F, Perez, Mr, Fenollar, M, García, Rg, Quiroga, Pp, Rivera, Sv, Villanueva, C, Bascuñana, M, Ventura, Mf, Ribas, Gg, de Yébenes, Jg, Moreno, Jl, Ruíz, Pj, Martínez Descals, A, Artiga, Mj, Sánchez, V, Perea, Mf, Lorenza, F, Torres, Mm, Reinante, G, Moreau, Lv, Barbera, Ma, Guia, Db, Hernanz, Lc, Catena, Jl, Ferrer, Pq, Carruesco, Gt, Bas, J, Busquets, N, Calopa, M, Buongiorno, Mt, Muñoz, E, Elorza, Md, López, Cd, Terol, Sd, Robert, Mf, Ruíz, Bg, Casado, Ag, Martínez, Ih, Viladrich, Cm, Pons i., Càrdenas R, Roca, E, Llesoy, Jr, Idiago, Jm, Vergara, Mr, García, S, Villa Riballo, A, González, Sg, Guisasola, Lm, Salvador, C, San Martín, E, Gorospe, A, Legarda, I, Arques, Pn, Rodríguez, Mj, Vives, B, Gaston, I, Ramos Arroyo, Ma, Moreno, Jm, Peña, Jc, Avarvarei, Ld, Bastida, Am, Recio, Mf, Vergé, Lr, Carrillo, F, Cáceres, Mt, Mir, P, Suarez, Mj, Bosca, M, Burguera, Ja, Garcia, Ac, Martínez, Lm, del Val, Jl, Loutfi, G, Olofsson, C, Stattin, El, Westman, L, Wikström, B, Höglund, A, Pålhagen, Se, Paucar, M, Sandström, B, Soltani, R, Svenningsson, P, Reza Soltani, Tw, Constantinescu, R, Fredlund, G, Høsterey Ugander, U, Neleborn Lingefjärd, L, Esmaeilzadeh, M, Tedroff, J, Winnberg, E, Björn, Y, Ekwall, C, Gøller, Ml, Johansson, A, Wiklund, L, Petersen, Å, Reimer, J, Widner, H, Burgunder, Y, Stebler, Y, Kaelin, A, Romero, I, Schüpbach, M, Zaugg, Sw, Jack, R, Matheson, K, Miedzybrodzka, Z, Rae, D, Simpson, S, Summers, F, Ure, A, Crooks, J, Curtis, A, de Souza Keylock, J, Rickards, H, Wright, J, Hayward, B, Sieradzan, K, Wright, A, Barker, Ra, Di Pietro, A, Fisher, K, Goodman, A, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Clenaghan, C, Ellison Rose, L, Handley, O, Hunt, S, Price, K, Rosser, A, Edwards, M, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Smith, P, Zeman, A, Causley, A, Harrower, T, Howcroft, D, Lambord, N, Rankin, J, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Miller, J, Ritchie, S, Burrows, L, Fletcher, A, Harding, A, Laver, F, Silva, M, Thomson, A, Burns, P, Chu, C, Evans, C, Hamer, S, Markova, I, Raman, A, Barnes, K, Hobson, E, Jamieson, S, Thomson, J, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Clapton, J, Grant, D, Hallam, C, Middleton, J, Murch, A, Patino, D, Bate, L, Pate, L, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Patton, M, Peterson, M, Rose, S, Bruno, S, Chu, E, Doherty, K, Henley, S, Lahiri, N, Novak, M, Patel, A, Read, J, Rosser, E, Say, M, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Callaghan, J, Craufurd, D, Fullam, R, Howard, L, Huson, S, Oughton, E, Partington Jones, L, Snowden, J, Sollom, A, Stopford, C, Thompson, J, Trender Gerhad, I, Verstraelen, N, Westmoreland, L, Nemeth, Ah, Siuda, G, Harrison, D, Hughes, M, Parkinson, A, Soltysiak, B, Burn, J, Coleman, C, Majeed, T, Verstraelen Ritchie, N, Bandmann, O, Bradbury, A, Gill, P, Fairtlough, H, Fillingham, K, Foustanos, I, O'Donovan, K, Tidswell, K, Quarrell, O., Faculty of Economic and Social Sciences and Solvay Business School, Neurology, Clinical sciences, Neuroprotection & Neuromodulation, Orth M., European Huntington's Disease Network, Handley O.J., Schwenke C., Dunnet S., Wild E.J., Tabrizi S.J., Landwehrmeyer G.B., Capellari S., Cortelli P., Gallassi R., Poda R., Rizzo G., and Scaglione C.
Subjects: Gerontology, medicine.medical_specialty, Neurology, International Cooperation, Disease, Irritability, Data Collection/methods, Huntington's disease, medicine, Humans, Registries, Psychiatry, Suicidal ideation, Disease burden, business.industry, Data Collection, medicine.disease, Europe, Huntington Disease, Psychiatry and Mental health, European Huntington's Disease Network, Surgery, Observational study, Neurology (clinical), medicine.symptom, business
Abstract: BACKGROUND: Huntington's disease (HD) is a rare triplet repeat (CAG) disorder. Advanced, multi-centre, multi-national research frameworks are needed to study simultaneously multiple complementary aspects of HD. This includes the natural history of HD, its management and the collection of clinical information and biosamples for research. METHODS: We report on cross-sectional data of the first 1766 participants in REGISTRY, the European Huntington's Disease Network's (EHDN), multi-lingual, multi-national prospective observational study of HD in Europe. Data collection (demographics, phenotype, genotype, medication, co-morbidities, biosamples) followed a standard protocol. RESULTS: Phenotype, and the HD genotype, of manifest HD participants across different European regions was similar. Motor onset was most common (48%) with a non-motor onset in more than a third of participants. Motor signs increased, and cognitive abilities and functional capacity declined as the disease burden (CAGn-35.5) X age) increased. A life-time history of behavioural symptoms was common, but the behavioural score was not related to disease burden. One fifth of participants had severe psychiatric problems, e.g. suicidal ideation and attempts, and/or irritability/aggression, with psychosis being less common. Participants on anti-dyskinetic medication had a higher motor and lower cognitive score, were older, and more prone to physical trauma. A higher motor and a lower cognitive score predicted more advanced disease. CONCLUSIONS: The unparalleled collection of clinical data and biomaterials within the EHDN's REGISTRY can expedite the search for disease modifiers (genetic and environmental) of age at onset and disease progression that could be harnessed for the development of novel treatments.
Published: 2011

11. Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease

Author: Aziz, Na, Jurgens, Ck, Landwehrmeyer, Gb, Ehdn, Rsg, van Roon Mom, Wm, van Ommen, Gj, Stijnen, T, Roos, Ra, Bachoud Levi, Ac, Bentivoglio, Ar, Biunno, I, Bonelli, R, Burgunder, Jm, Dunnett, Sb, Ferreira, J, Handley, Oj, Heiberg, A, Illmann, T, Levey, J, Nielsen, Je, Päivärinta, M, Rojo Sebastian, A, Tabrizi, Sj, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlstrom, J, Schwenke, C, Orth, M, Wallner, M, Barth, K, Bascunana Garde, M, Ros, R, Ecker, D, Heinonen, N, Held, C, Laura, M, Martinez Descals, A, Mestre, T, Monza, D, Naji, J, Padieu, H, Pro Koivisto, S, Rialland, A, Sasinkova, P, Trigo Cubillo, P, van Walsem, M, Witjes Ane, Mn, Zielonka, D, Bonelli, Rm, Herranhof, B, Hodl, A, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Flamez, A, Morez, V, de Raedt, S, Ribai, P, Van Reijen, D, Hasholt, L, Hjermind, Le, Jakobsen, O, Norremolle, A, Sorensen, Sa, Stokholm, J, Peippo, M, Sipponen, M, Hiivola, H, Martikainen, K, Tuuha, K, Kosinski, Cm, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Priller, J, Prüb, H, Andrich, J, Hoffmann, R, Kraus, P, Prehn, C, Saft, C, Salmen, S, Strabburger, K, Lange, H, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lammbeck, J, Zucker, B, Hidding, U, Münchau, A, Stubbe, L, Heinicke, W, Longinus, B, Möller, Jc, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bohlen, S, Reilmann, R, Beuster, A, Dose, M, Leythaeuser, G, Marquard, R, Schrenk, C, Schuierer, M, Wiedemann, A, Landwehrmeyer, B, Lezius, F, Trautmann, S, Bertini, E, Mechi, C, Paganini, M, Piacentini, S, Romoli, M, Sorbi, S, Abbruzzese, Giovanni, Bandettini di Poggio, M, Ferrandes, G, Mandes, P, Marchese, R, Albanese, A, Di Donato, S, Mariotti, C, Soliveri, P, Carlo, R, Luigi, Dm, De michele, G, Rinaldi, C, Salvatore, E, Tucci, T, Ciarmiello, A, Martino, T, Simonelli, M, Squitieri, F, Fasano, A, Frontali, M, Guidubaldi, A, Lalongo, T, Jacopini, G, Loria, G, Piano, C, Romano, S, Soleti, F, Spadaro, M, Zinzi, P, van Walsem, Mr, Bjørgo, K, Fannemel, M, Gørvell, P, Retterstøl, L, Bjørnevoll, I, Sando, Sb, Sitek, Ej, Slawek, J, Soltan, W, Rudzinska, M, Szczudlik, A, Wójcik, M, Bryl, A, Ciesielska, A, Klimberg, A, Kozubski, W, Marcinkowski, J, Sempolowicz, Pj, Zielona, D, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Rakowicz, M, Richter, P, Ryglewicz, D, Zdzienicka, E, Costa, C, Coelho, M, Ferreira, Jj, Rosa, Mm, Valadas, A, Gago, M, Garrett, C, Guerra, Mr, Bas, J, Calopa, M, Barberà, Ma, Badenes, D, Casas, L, Arroyo, Se, Vara, Jh, Krupinski, J, López, J, Obdulia, M, Ferrer, Pq, Sebastián, Ar, Contreras, Sr, Carruesco, Gt, Cubo, E, Mariscal, N, Sánchez, J, Barrero, Fj, Morales, B, Garcia Ramos Garcia, R, Pin Quiroga, P, Villanueva, C, Ruiz Espiga, Pj, Martinez, A, Saiz Artiga, Mj, Sánchez, V, Bascuñana, M, Fatas, M, Ribas, Gg, de Yébenes, Jg, López Moreno, Jl, Schwarz, C, Cubillo, Pt, Arques, Pn, Gorospe, A, Legarda, I, Rodriguez, Mj, Gaston, I, Ramos Arroyo, Ma, del Val, Jl, Martinez, L, Romero, I, Schüpbach, M, Zaugg, Sw, van Hout, Ms, van Vugt, Jp, de Weert, Am, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom, Jc, Bos, R, Dumas, E, Witjes Ané, Mn, Matheson, K, Rae, D, Simpson, S, Summers, F, Ure, A, Curtis, A, Keylock, J, Rickards, H, Wright, J, Barker, Ra, Fisher, K, Goyder Goodman, Ao, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Ellison Rose, L, Handley, O, Price, K, Rosser, A, Edwards, M, De Sousa, Pa, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Zema, A, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Thomas, G, Burrows, L, Fletcher, A, Laver, F, Silva, M, Thomas, A, Chu, C, Hobson, E, Jamieson, S, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Grant, J, Gross, D, Hallam, C, Middleton, J, Murch, A, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Bruno, S, Henley, S, O'Driscoll, C, Patel, A, Rosser, E, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Craufurd, D, Fullam, R, Howard, L, Huson, S, Partington Jones, L, Ritchie, N, Snowden, J, Solom, A, Stopford, C, Thompson, J, Westmoreland, L, Nemeth, Ah, Siuda, G, Bandmann, O, Bradbury, A, Fillingham, K, Foustanos, I, Quarrell, O, Reynders, H, Robertson, L, Tidswell, K., Mandich, Paola, Aziz, Na, Jurgens, Ck, Landwehrmeyer, Gb, EHDN Registry Study, Group, van Roon Mom, Wm, van Ommen, Gj, Stijnen, T, Bachoud Levi AC, Roos R. A., Bentivoglio, Ar, Biunno, I, Bonelli, R, Burgunder, Jm, Dunnett, Sb, Ferreira, J, Handley, Oj, Heiberg, A, Illmann, T, Levey, J, Nielsen, Je, Päivärinta, M, Roos, Ra, Rojo Sebastian, A, Tabrizi, Sj, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlstrom, J, Schwenke, C, Orth, M, Wallner, M, Barth, K, Bascunana Garde, M, Ros, R, Ecker, D, Heinonen, N, Held, C, Laura, M, Martinez Descals, A, Mestre, T, Monza, D, Naji, J, Padieu, H, Pro Koivisto, S, Rialland, A, Sasinkova, P, Trigo Cubillo, P, van Walsem, M, Witjes Ane, Mn, Zielonka, D, Bonelli, Rm, Herranhof, B, Hodl, A, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Flamez, A, Morez, V, de Raedt, S, Ribai, P, Van Reijen, D, Hasholt, L, Hjermind, Le, Jakobsen, O, Norremolle, A, Sorensen, Sa, Stokholm, J, Peippo, M, Sipponen, M, Hiivola, H, Martikainen, K, Tuuha, K, Kosinski, Cm, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Priller, J, Prüb, H, Andrich, J, Hoffmann, R, Kraus, P, Prehn, C, Saft, C, Salmen, S, Strabburger, K, Lange, H, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lammbeck, J, Zucker, B, Hidding, U, Münchau, A, Stubbe, L, Heinicke, W, Longinus, B, Möller, Jc, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bohlen, S, Reilmann, R, Beuster, A, Dose, M, Leythaeuser, G, Marquard, R, Schrenk, C, Schuierer, M, Wiedemann, A, Landwehrmeyer, B, Lezius, F, Trautmann, S, Bertini, E, Mechi, C, Paganini, M, Piacentini, S, Romoli, M, Sorbi, S, Abbruzzese, G, Bandettini di Poggio, M, Ferrandes, G, Mandes, P, Marchese, R, Albanese, A, Di Donato, S, Mariotti, C, Soliveri, P, Carlo, R, Luigi, Dm, DE MICHELE, Giuseppe, Rinaldi, Carlo, Salvatore, Elena, Tucci, Tecla, Ciarmielo, A, Martino, T, Simonelli, M, Squitieri, F, Fasano, A, Frontali, M, Guidubaldi, A, Lalongo, T, Jacopini, G, Loria, G, Piano, C, Romano, S, Soleti, F, Spadaro, M, Zinzi, P, van Walsem, Mr, Bjørgo, K, Fannemel, M, Gørvell, P, Retterstøl, L, Bjørnevoll, I, Sando, Sb, Sitek, Ej, Slawek, J, Soltan, W, Rudzinska, M, Szczudlik, A, Wójcik, M, Bryl, A, Ciesielska, A, Klimberg, A, Kozubski, W, Marcinkowski, J, Sempolowicz, Pj, Zielona, D, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Rakowicz, M, Richter, P, Ryglewicz, D, Zdzienicka, E, Costa, C, Coelho, M, Ferreira, Jj, Rosa, Mm, Valadas, A, Gago, M, Garrett, C, Guerra, Mr, Bas, J, Calopa, M, Barberà, Ma, Badenes, D, Casas, L, Arroyo, Se, Vara, Jh, Krupinski, J, López, J, Obdulia, M, Ferrer, Pq, Sebastián, Ar, Contreras, Sr, Carruesco, Gt, Cubo, E, Mariscal, N, Sánchez, J, Barrero, Fj, Morales, B, Garcia Ramos Garcia, R, Pin Quiroga, P, Villanueva, C, Ruiz Espiga, Pj, Martinez, A, Saiz Artiga, Mj, Sánchez, V, Bascuñana, M, Fatas, M, Ribas, Gg, de Yébenes, Jg, López Moreno, Jl, Schwarz, C, Cubillo, Pt, Arques, Pn, Gorospe, A, Legarda, I, Rodriguez, Mj, Gaston, I, Ramos Arroyo, Ma, del Val, Jl, Martinez, L, Romero, I, Schüpbach, M, Zaugg, Sw, van Hout, M, van Vugt, Jp, de Weert, Am, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom, Jc, Bos, R, Dumas, E, Witjes Ané, Mn, Matheson, K, Rae, D, Simpson, S, Summers, F, Ure, A, Curtis, A, Keylock, J, Rickards, H, Wright, J, Barker, Ra, Fisher, K, Goyder Goodman, Ao, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Ellison Rose, L, Handley, O, Price, K, Rosser, A, Edwards, M, De Sousa, Pa, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Zema, A, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Thomas, G, Burrows, L, Fletcher, A, Laver, F, Silva, M, Thomas, A, Chu, C, Hobson, E, Jamieson, S, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Grant, J, Gross, D, Hallam, C, Middleton, J, Murch, A, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Bruno, S, Henley, S, O'Driscoll, C, Patel, A, Rosser, E, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Craufurd, D, Fullam, R, Howard, L, Huson, S, Partington Jones, L, Ritchie, N, Snowden, J, Solom, A, Stopford, C, Thompson, J, Westmoreland, L, Nemeth, Ah, Siuda, G, Bandmann, O, Bradbury, A, Fillingham, K, Foustanos, I, Quarrell, O, Reynders, H, Robertson, L, Tidswell, K., Neurology, Clinical sciences, and Neuroprotection & Neuromodulation
Subjects: Adult, Male, medicine.medical_specialty, Pathology, congenital, hereditary, and neonatal diseases and abnormalities, Huntingtin, Adolescent, Huntington Disease/epidemiology, Serotonin Plasma Membrane Transport Proteins/genetics, Severity of Illness Index, Basal Ganglia, Central nervous system disease, Young Adult, Degenerative disease, Internal medicine, Basal ganglia, Severity of illness, mental disorders, medicine, Humans, Prospective Studies, Allele, Age of Onset, Child, Basal Ganglia/pathology, Aged, Serotonin Plasma Membrane Transport Proteins, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Endocrinology, Huntington Disease, Mutation, Disease Progression, Female, Neurology (clinical), Age of onset, Trinucleotide repeat expansion, Psychology, Trinucleotide Repeat Expansion, Follow-Up Studies
Abstract: OBJECTIVE: Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion in the HD gene (HTT). We aimed to assess whether interaction between CAG repeat sizes in the mutant and normal allele could affect disease severity and progression. METHODS: Using linear regression and mixed-effects models, the influence of mutant and normal CAG repeat sizes interaction was assessed on 1) age at onset in 921 patients with HD, 2) clinical severity and progression in 512 of these patients with follow-up data available, and 3) basal ganglia volume on magnetic resonance images in 16 premanifest HD mutation carriers. RESULTS: Normal and mutant CAG repeat sizes interacted to influence 1) age at onset (p = 0.001), 2) severity or progression of motor, cognitive, and functional, but not behavioral, symptoms in patients with HD (all p < 0.05), and 3) in premanifest subjects, basal ganglia volumes (p < 0.05). In subjects with mutant CAG expansions in the low range, increasing size of the normal repeat correlated with more severe symptoms and pathology, whereas for those subjects with expansions in the high range, increasing size of the normal repeat correlated with less severe symptoms and pathology. CONCLUSIONS: Increasing CAG repeat size in normal HTT diminishes the association between mutant CAG repeat size and disease severity and progression in Huntington disease. The underlying mechanism may involve interaction of the polyglutamine domains of normal and mutant huntingtin (fragments) and needs further elucidation. These findings may have predictive value and are essential for the design and interpretation of future therapeutic trials.
Published: 2009

12. β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease

Author: Vittori, A, Orth, M, Roos, Ra, Outeiro, Tf, Giorgini, F, Hollox, Ej, Bachoud-Levi, Ac, Bentivoglio, Ar, Biunno, I, Bonelli, Rm, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Handley, Oj, Heiberg, A, Illmann, T, Landwehrmeyer, Gb, Levey, J, Martinez-Jaurrieta, Md, Nielsen, Je, Pro Koivisto, S, Piiiviirinta, M, Sebastian, Ar, Tabrizi, Sj, Vandenberghe, W, Verellen-Dumoulin, C, Zaremba, J, Uhrova, T, Wahlstrom, J, Barth, K, Correia-Guedes, L, Finisterra, Am, Bascuiiana Garde, M, Betz, S, Bos, R, Ecker, D, Held, C, Koppers, K, Laura, M, Descals, Am, Mestre, T, Monza, D, Townhill, J, Padieu, H, Paterski, L, Peppa, N, Rialland, A, Røren, N, Sasinkova, P, Trigo Cubillo, P, van Walsem, M, Witjes-Ane, Mn, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Herranhof, B, Hod, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinge, K, Scheib, M, Hecht, K, Lilek, S, Muller, N, Schoggl, H, Ullah, J, Ribal, P, Klempff, J, Majerova, V, Roth, J, Hjermind, Le, Jakobsen, O, Vinthev-Jensen, T, Larsen, Iu, Stokholm, J, Hiivola, H, Martikainen, K, Tuuha, K, Santala, M, Milkereit, E, Kosinski, Cm, Probst, D, Reetz, K, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Andrich, J, Ellrichmann, G, Hoffmann, R, Kaminski, B, Saft, C, Stamm, C, Lange, H, Lohle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Capetian, P, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Hidding, U, Lewerenz, J, Miinchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Heinicke, W, Ribbat, M, Longinus, B, Miihlau, M, Peinemann, A, Stiidtler, M, Weindl, A, Winkelmann, J, Ziegler, C, Bechtel, N, Beckmann, H, Bohlen, S, Holzner, E, Reilmann, R, Rohm, S, Rumpf, S, Schepers, S, Dose, M, Leythaeuser, G, Marquard, R, Raab, T, Schrenk, C, Schuierer, M, Buck, A, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Schwenk, D, Siissmuth, S, Trautmann, S, Weydt, P, Cormio, C, de Tommaso, M, Sciruicchio, V, Serpino, C, Ghelli, E, Ginestroni, A, Bertini, E, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, Ferrandes, Mb, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Soliveri, P, Tomasello, C, De Michele, G, Dimaio, L, Massarelli, M, Rinaldi, C, Roca, A, Rossi, F, Russo, Cv, Salvatore, E, Sorrentino, P, Tucci, T, De Nicola, A, Elifani, F, Petrollini, M, Martino, T, Lovo, F, Squitieri, F, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Piano, C, Piccininni, C, Quaranta, D, Romano, S, Soleti, F, Spadaro, M, van Hout MS, van Vugt JP, de Weert, A, Bolwijn, Jj, Neurologie, P, Dekker, M, Leenders, Kl, van Oostrom JC, Dumas, Em, Jurgens, Ck, van den Bogaard SJ, 't Hart EP, Kremer, B, Verstappen, Cc, van Walsem MR, Frich, J, Aaserud, O, Wehus, R, Bjørgo, K, Fannemel, M, Gørvell, P, Lorentzen, E, Koivisto, Sp, Retterstøl, L, Stokke, B, Bjørnevoll, I, Sando, Sb, Dziadkiewicz, A, Nowak, M, Robowski, P, Sitek, E, Slawek, J, Soltan, W, Szinwelski, M, Blaszczyk, M, Boczarska-Jedynak, M, Ciach-Wysocka, E, Gorzkowska, A, Jasinska-Myga, B, Opala, G, Klodowska, G, Stompel, D, Banaszkiewicz, K, Boewiriska, D, Bojakowska-Jaremek, K, Neurologii, A, Dec, M, Krawczyk, M, Rudziriska, M, Szczudlik, A, Szczygiel, E, Wasielewska, A, Wojcik, M, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Samara, H, Sempolowicz, J, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Jachinska, K, Krysa, W, Rakowicz, M, Richter, P, Rola, R, Ryglewicz, D, Sienkiewicz-Jarosz, H, Sulek, A, Witkowski, G, Zdzienicka, E, Zieora-Jakutowicz, K, Coelho, M, Mendes, T, Valadas, A, Andrade, C, Joao, Ps, Gago, M, Garrett, C, Guerra, Mr, Solis, P, Herrera, Cd, Garcia, Pm, Cubo, E, Mariscal, N, Sanchez, J, Barrero, Fj, Alonso-Frech, F, Perez, Mr, Fenollar, M, Garda, R, Rivera, Sv, Villanueva, C, Alegre, J, Bascuiiana, M, Ventura, Mf, Ribas, Gg, Moreno, Jl, Cubillo, Pt, Rufz, Pj, Frech, Fa, Dfaz, J, Guerrero, R, Artiga, Mj, Sanchez, V, Alcaraz, Lf, de Ia Arrixaca, V, Manzanares, S, Perea, Mf, Reinante, G, Arrixaca, Ia, Torres, Mm, Moreau, Lv, Barbera, Ma, Guia, Db, Hernanz, Lc, Catena, Jl, Sebastian, R, Ferrer, Pq, Carruesco, Gt, Bas, J, Busquets, N, Calopa, M, Buongiorno, Mt, Munoz, E, Elorza, Md, Lopez, Cd, Terol, Ds, Robert, Mf, Rufz, Bg, Casado, Ag, Martinez, Ih, Viladrich, Cm, Pons, R, Roca, E, Llesoy, Jr, Idiago, Jm, Vergara, Mr, Garcia, Ss, Riballo, Av, Hoglund, A, Palhagen, Se, Paucar, M, Sandstrom, B, Svenningsson, P, Reza-Soltani, Tw, Kaelin, A, Romero, I, Schupbach, M, Stebler, Y, Zaugg, Sw, Akhtar, S, Crooks, J, Curtis, A, de Souza, J, Rickards, H, Wright, J, Barker, Ra, Di Pietro, A, Fisher, K, Goodman, Ao, Hill, S, Kershaw, A, Mason, S, O'Keefe, D, Swain, R, Guzman, Nv, Busse, M, Butcher, C, Clenaghan, C, Dunnett, S, Fullam, R, Jones, L, Jones, U, Khalil, H, Minster, S, Owen, M, Hunt, S, Price, K, Rosser, A, Edwards, M, Ho, C, Mcgill, M, Pearson, P, Porteous, M, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Burrows, L, Chu, C, Fletcher, A, Gallantrae, D, Harding, A, Hamer, S, Kraus, A, Laver, F, Longthorpe, M, Markova, I, Raman, A, Silva, M, Thomson, A, Wild, S, Yardumian, P, Hobson, E, Jamieson, S, Musgrave, H, Rowett, L, Toscano, J, Clayton, C, Dipple, H, Middleton, J, Patino, D, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Laing, H, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Santhouse, A, Bruno, S, Doherty, K, Lahiri, N, Novak, M, Patel, A, Rosser, E, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Bek, J, Callaghan, J, Craufurd, D, Howard, L, Hare, M, Huson, S, Johnson, L, Jones, M, Murphy, H, Oughton, E, Partington-Janes, L, Rogers, D, Snowden, J, Sollom, A, Stopford, C, Thompson, J, Trender-Gerhard, I., Vittori, Angelica, Orth, Michael, Roos, Raymund A C, Outeiro, Tiago F, Giorgini, F, Russo, Cinzia Valeria, Flaviano, and Hollox, Edward J
Subjects: Adult, Male, Age of Onset, DNA Copy Number Variations, Female, Genotype, Humans, Huntington Disease, Middle Aged, beta-Defensins, Disease, Biology, Genetic modifier, Article, Pathogenesis, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Huntington's disease, medicine, Copy-number variation, Defensin, 030304 developmental biology, Genetics, 0303 health sciences, copy number variation, inflammation, Acquired immune system, medicine.disease, 3. Good health, Beta defensin, Neurology (clinical), Age of onset, 030217 neurology & neurosurgery
Abstract: Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of a CAG triplet repeat tract in the huntingtin gene. While the length of this CAG expansion is the major determinant of the age of onset (AO), other genetic factors have also been shown to play a modulatory role. Recent evidence suggests that neuroinflammations is a pivotal factor in the pathogenesis of HD, and that targeting this process may have important therapeutic ramifications. The human β-defensin 2 (hBD2)- encoded by DEFB4- is an antimicrobial peptide that exhibits inducible expression in astrocytes during inflammation and is an important regulator of innate and adaptive immune response. Therefore, DEFB4 may contribute to the neuroinflammatory processes observed in HD. Objective: In this study we tested the hypothesis that copy number variation (CNV) of the β-defensin region, including DEFB4, modifies the AO in HD. Methods and results: We genotyped β-defensin CNV in 490 HD individuals using the paralogue ratio test and found no association between β-defensin CNV and onset of HD. Conclusions: We conclude that it is unlikely that DEFB4 plays a role in HD pathogenesis.
Published: 2013

13. Discrepancies in reporting the CAG repeat lengths for Huntington's disease

Author: Quarrell, Ow, Handley, O, O'Donovan, K, Dumoulin, C, Ramos Arroyo, M, Biunno, I, Bauer, P, Kline, M, Landwehrmeyer, Gb, Barth, K, Correia Guedes, L, Maria Finisterra, A, Bascuñana Garde, M, Bos, R, Ecker, D, Held, C, Koppers, K, Laurà, M, Martínez Descals, A, Mclean, T, Mestre, T, Minster, S, Monza, D, Townhill, J, Orth, M, Padieu, H, Paterski, L, Peppa, N, Koivisto, Sp, Rialland, A, Røren, N, Šašinková, P, Cubillo, Pt, van Walsem MR, Witjes Ané MN, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Bachoud Lévi AC, Bentivoglio, Ar, Bonelli, R, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Handley, Oj, Heiberg, A, Illmann, T, Levey, J, Nielsen, Je, Päivärinta, M, Roos, Ra, Rojo Sebastián, A, Tabrizi, Sj, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlström, J, Bonelli, Rm, Herranhof, B, Holl, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Scheibl, M, Hecht, K, Lilek, S, Müller, N, Schöggl, H, Ullah, J, Brugger, F, Hepperger, C, Hotter, A, Mahlknecht, P, Nocker, M, Seppi, K, Wenning, G, Buratti, L, Hametner, Em, Holas, C, Hussl, A, Mair, K, Poewe, W, Wolf, E, Zangerl, A, Braunwarth, Em, Ribaï, P, Flamez, A, Morez, V, de Raedt, S, Boogaerts, A, van Reijen, D, Klempíř, J, Kucharík, M, Roth, J, Hjermind, Le, Jakobsen, O, Stokholm, J, Hasholt, L, Nørremølle, A, Sørensen, Sa, Hiivola, H, Martikainen, K, Tuuha, K, Peippo, M, Sipponen, M, Kosinski, Cm, Milkereit, E, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Gelderblom, H, Priller, J, Prüss, H, Spruth, Ej, Andrich, J, Hoffmann, R, Kraus, Ph, Muth, S, Prehn, C, Saft, C, Salmen, S, Stamm, C, Steiner, T, Strassburger, K, Lange, H, Friedrich, A, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Hidding, U, Lewerenz, J, Münchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Heinicke, W, Longinus, B, Uni, M, Bürk, K, Möller, Jc, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bechtel, N, Beckmann, H, Bohlen, S, Hölzner, E, Reilmann, R, Rohm, S, Rumpf, S, Schepers, S, Beister, A, Dose, M, Hammer, K, Kieni, J, Leythaeuser, G, Marquard, R, Raab, T, Richter, S, Selimbegovic Turkovic, A, Schrenk, C, Schuierer, M, Wiedemann, A, Buck, A, Connemann, J, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Süssmuth, S, Trautmann, S, Weydt, P, Cormio, C, Difruscolo, O, Sciruicchio, V, Serpino, C, de Tommaso, M, Capellari, S, Cortelli, P, Gallassi, R, Poda, R, Rizzo, G, Scaglione, C, Bertini, E, Ghelli, E, Ginestroni, A, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, Bandettini di Poggio, M, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Bella, D, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Paridi, D, Soliveri, P, Tomasello, C, De Michele, G, Di Maio, L, Rinaldi, C, Valeria Russo, C, Salvatore, E, Tucci, T, Cannella, M, Codella, V, De Gregorio, F, De Nicola, N, Martino, T, Simonelli, M, Squitieri, F, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Modoni, A, Piano, C, Piccininni, C, Quaranta, D, Romano, Silvia, Soleti, F, Spadaro, M, van Hout MS, van Vugt JP, Marit de Weert, A, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom JC, Dumas, Em, Jurgens, Ck, van den Bogaard SJ, 't Hart EP, Kremer, B, Verstappen, Cc, Aaserud, O, Wehus, R, Bjørgo, K, Fannemel, M, Gørvell, P, Retterstøl, L, Overland, T, Stokke, B, Bjørnevoll, I, Sando, Sb, Sitek, E, Slawek, J, Soltan, W, Boczarska Jedynak, M, Jasinska Myga, B, Opala, G, Kodowska Duda, G, Banaszkiewicz, K, Szczudlik, A, Rudziñska, M, Wójcik, M, Dec, M, Krawczyk, M, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Sempoowicz, J, Samara, H, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Jachinska, K, Rakowicz, M, Richter, P, Ryglewicz, D, Witkowski, G, Zdzienicka, E, Suek, A, Krysa, W, Guedes, L, Coelho, M, Mendes, T, Valadas, A, Cavaco, S, Damásio, J, Magalhães, M, Gago, M, Garrett, C, Guerra, Mr, Barrero, F, Morales, B, Cubo, E, Mariscal, N, Sánchez, J, Alonso Frech, F, Rabasa Perez, M, Fenollar, M, García, R, Quiroga, Pp, Vázquez Rivera, S, Villanueva, C, Bascuñana, M, Fatás Ventura, M, García Ribas, G, García de Yébenes, J, López Sendón Moreno JL, García Ruíz PJ, José Saiz Artiga, M, Sánchez, V, Noguera Perea, F, Lorenza, F, Torres, Mm, Reinante, G, Vivancos Moreau, L, Barbera, Ma, Badenes Guia, D, Hernanz, Lc, Catena, Jl, Ferrer, Pq, Tome Carruesco, G, Bas, J, Busquets, N, Calopa, M, Dalmau Elorza, M, Díez, C, López, A, Durán, S, Terol, S, Floriach Robert, M, Garzón Ruíz, B, González Casado, A, Haro Martínez, I, Viladrich, Cm, Càrdenas R, Pons i., Roca, E, Llesoy, Jr, Ruiz Idiago JM, Ruíz Vergara, M, Soriano García, S, Villa Riballo, A, Gorospe, A, Legarda, I, Arques, Pn, Torres Rodríguez MJ, Vives, B, Gaston, I, Bosca, M, Burguera, Ja, Garcia, Ac, Pålhagen, Se, Paucar, M, Svenningsson, P, Walldén Reza Soltani, T, Höglund, A, Sandström, B, Høsterey Ugander, U, Fredlund, G, Constantinescu, R, Neleborn Lingefjärd, L, Tedroff, J, Esmaeilzadeh, M, Winnberg, E, Burgunder, Y, Stebler, Y, Kaelin, A, Romero, I, Schüpbach, M, Zaugg, Sw, Jack, R, Matheson, K, Miedzybrodzka, Z, Rae, D, Simpson, S, Summers, F, Ure, A, Crooks, J, Curtis, A, de Souza, J, Rickards, H, Wright, J, Barker, Ra, Di Pietro, A, Fisher, K, Goodman, A, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Clenaghan, C, Ellison Rose, L, Hunt, S, Price, K, Rosser, A, Edwards, M, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Smith, P, Zeman, A, Causley, A, Harrower, T, Howcroft, D, Lambord, N, Rankin, J, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Miller, J, Ritchie, S, Burrows, L, Fletcher, A, Harding, A, Laver, F, Silva, M, Thomson, A, Barnes, K, Chu, C, Hobson, E, Jamieson, S, Markova, I, Thomson, J, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Clapton, J, Grant, J, Gross, D, Hallam, C, Middleton, J, Murch, A, Patino, D, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Patton, M, Peterson, M, Rose, S, Bruno, S, Chu, E, Doherty, K, Henley, S, Lahiri, N, Novak, M, Patel, A, Read, J, Rosser, E, Say, M, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Callaghan, J, Craufurd, D, Fullam, R, Howard, L, Huson, S, Oughton, E, Partington Jones, L, Snowden, J, Sollom, A, Stopford, C, Thompson, J, Trender Gerhad, I, Verstraelen, N, Westmoreland, L, Nemeth, Ah, Suida, G, Harrison, D, Hughes, M, Parkinson, A, Soltysiak, B, Bandmann, O, Bradbury, A, Gill, P, Fairtlough, H, Fillingham, K, Foustanos, I, Tidswell, K., Kaelin, André, Quarrel O.W., Handley O., O'Donovan K., Dumoulin C., Ramos-Arroyo M., Biunno I., Bauer P., Kline M., Capellari S., Cortelli P., Gallassi R., Landwehrmeyer G.B., European Huntington's Disease Network., Neurology, Clinical sciences, Neuroprotection & Neuromodulation, Quarrell, Ow, Handley, O, O'Donovan, K, Dumoulin, C, Ramos Arroyo, M, Biunno, I, Bauer, P, Kline, M, Landwehrmeyer, Gb, European Huntington's Disease, Network, European Huntington's Disease, N. e. t. w. o. r. k., Rinaldi, Carlo, Salvatore, Elena, and DE MICHELE, Giuseppe
Subjects: medicine.medical_specialty, Concordance, International Cooperation, Diagnostic Errors/statistics & numerical data, Nerve Tissue Proteins, Guidelines as Topic, Bioinformatics, Sensitivity and Specificity, Article, Huntingtin Gene, Huntington's disease, Trinucleotide Repeats, Internal medicine, External quality assessment, Genetics, medicine, Humans, Nerve Tissue Proteins/genetics, Diagnostic laboratory, Genetic Testing, Genetic Testing/methods/standards, Allele, Diagnostic Errors, standard reference material, Genetics (clinical), Alleles, Huntingtin Protein, ddc:618, business.industry, international cooperation, Nuclear Proteins, Reproducibility of Results, Reference Standards, medicine.disease, CAG repeat length, Nuclear Proteins/genetics, Huntington Disease, Huntington Disease/diagnosis, Mutation, Medical genetics, reproducibility of results, mutation, business, Trinucleotide repeat expansion, Huntington Disease/diagnosis/genetics, Genetic Testing/methods
Abstract: Huntington's disease results from a CAG repeat expansion within the Huntingtin gene; this is measured routinely in diagnostic laboratories. The European Huntington's Disease Network REGISTRY project centrally measures CAG repeat lengths on fresh samples; these were compared with the original results from 121 laboratories across 15 countries. We report on 1326 duplicate results; a discrepancy in reporting the upper allele occurred in 51% of cases, this reduced to 13.3% and 9.7% when we applied acceptable measurement errors proposed by the American College of Medical Genetics and the Draft European Best Practice Guidelines, respectively. Duplicate results were available for 1250 lower alleles; discrepancies occurred in 40% of cases. Clinically significant discrepancies occurred in 4.0% of cases with a potential unexplained misdiagnosis rate of 0.3%. There was considerable variation in the discrepancy rate among 10 of the countries participating in this study. Out of 1326 samples, 348 were re-analysed by an accredited diagnostic laboratory, based in Germany, with concordance rates of 93% and 94% for the upper and lower alleles, respectively. This became 100% if the acceptable measurement errors were applied. The central laboratory correctly reported allele sizes for six standard reference samples, blind to the known result. Our study differs from external quality assessment (EQA) schemes in that these are duplicate results obtained from a large sample of patients across the whole diagnostic range. We strongly recommend that laboratories state an error rate for their measurement on the report, participate in EQA schemes and use reference materials regularly to adjust their own internal standards.
Published: 2012

14. Multidrug Resistant Bacteria in an Intensive Care Unit: relationship between excessive workload and increasing requirement of contact isolation

Author: Marra, AR, primary, Camargo, LFA, additional, Moura, D, additional, Guerra, MR, additional, Moreira, E, additional, Ilzuka, IJ, additional, Laselva, CR, additional, Yamashita, MAA, additional, Lamblet, LC, additional, and Knobel, E, additional
Published: 2001
Full Text: View/download PDF

15. Bilateral Brachial Neuritis after COVID-19: Case Report.

Author: Abdouni YA and Viamont-Guerra MR
Abstract: Brachial neuritis, or Parsonage-Turner syndrome, is a rare disease characterized by a sudden, self-limiting pain in the upper limb followed by weakness and atrophy of the shoulder girdle muscles. Bilateral brachial plexus involvement occurs in between 10 and 30% of the patients, but symptoms are usually asymmetrical. The most common etiological factors include infection (25 to 55%) and autoimmune conditions. Up to 16% of the patients infected by the new coronavirus variant (SARS-CoV2) had neuromuscular complications. We present the case of a patient with bilateral Parsonage-Turner syndrome shortly after severe COVID-19., Competing Interests: Conflito de Interesses Os autores declaram não haver conflito de interesses., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ( https://creativecommons.org/licenses/by/4.0/ ).)
Published: 2024
Full Text: View/download PDF

16. Molecular Exploration of Mycoplasma fermentans and Mycoplasma genitalium in Mexican Women with Cervicitis.

Author: Bustos-López AD, Escobedo-Guerra MR, López-Hurtado M, Villagrana-Zesati JR, Valdés-Ramírez M, Giono-Cerezo S, and Guerra-Infante FM
Abstract: Genital Mycoplasmas are implicated in adverse pregnancy outcomes and the development of infertility. However, the role of Mycoplasma fermentans in these outcomes has not been adequately studied; therefore, its participation in these sufferings requires further investigation. This study aimed to evaluate the prevalence of M. fermentans in pregnant and non-pregnant women. End-point PCR was used to analyze two hundred and twenty-eight endocervical samples for M. hominis , M. genitalium , M. fermentans , M. pirum , Ureaplasma urealyticum , and U. parvum diagnoses. The prevalence of Mycoplasma spp. was as follows: U. parvum was found in 83 samples (36.4%), U. urealyticum in 39 instances (17.1%), M. hominis in 36 (15.7%), M. fermentans in 32 (14%), M. genitalium in 15 (6.6%), and M. pirum in 0 samples. No association was found between the Mycoplasma spp. and some infertility conditions or adverse pregnancy. However, M. fermentans and M. hominis were found to be associated with bacterial vaginosis (RR = 3.4 CI 95% 1.85-6.3, p < 0.005). In conclusion, M. fermentans and M. hominis were isolated more often in women with bacterial vaginosis, which suggests that these bacteria could contribute to the development of this pathology.
Published: 2024
Full Text: View/download PDF

17. Mortality due to cervical and breast cancer in health regions of Brazil: impact of public policies on cancer care.

Author: Nogueira MC, Guerra MR, Bustamante-Teixeira MT, Azevedo E Silva G, Tomazelli J, Pereira DA, Ribeiro CM, Naghavi M, and Malta DC
Subjects: Humans, Brazil epidemiology, Female, Adult, Public Policy, Middle Aged, Income statistics & numerical data, Socioeconomic Factors, Spatio-Temporal Analysis, Uterine Cervical Neoplasms mortality, Breast Neoplasms mortality, Early Detection of Cancer statistics & numerical data
Abstract: Objective: This analysis assessed the association between regional income, screening coverage for cervical and breast cancer, and temporal trends in mortality from these cancers in different Brazilian health regions., Study Design: Spatiotemporal ecological study across 450 health regions of Brazil., Methods: Data from 2010 Demographic Census were used to assess income. Variations in income distribution within health regions were measured using the Gini index. Data on screening coverage were obtained from the Ambulatory Information System (SIA/SUS). Mortality was assessed from the Global Burden of Disease Study 2019 data. The average annual percentage change (AAPC) in cervical and breast cancer mortality rates, 2010-2018, was calculated by health regions. Results were presented in regional maps. The associations between income, screening coverage and mortality changes were estimated by bivariate spatial correlation., Results: Health regions located in the South and Southeast regions of Brazil had the greatest percentages of screening coverage and highest per capita incomes with the lowest Gini index values. From 2010 to 2018, mortality rates for cervical cancer were highest in the North and Northeast health regions. Breast cancer mortality rates were highest in the South and Southeast health regions. The AAPC in breast and cervical cancer mortality had a negative association with per capita income and screening coverage, and a positive association with the Gini index., Conclusions: There are large regional variations in income, screening coverage, and mortality rates for women with breast and cervical cancer. These inequities could be mitigated by policies to address income disparities and improved access to screening., (Copyright © 2024 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.)
Published: 2024
Full Text: View/download PDF

18. The burden of lung cancer and mortality attributable to occupational risk factors between 1990 and 2019 in Brazil and federative units.

Author: Girardi FA, Nogueira MC, Malta DC, Pissolati Simão FE, Bustamante-Teixeira MT, and Guerra MR
Subjects: Humans, Brazil epidemiology, Female, Male, Risk Factors, Disability-Adjusted Life Years, Middle Aged, Global Burden of Disease, Adult, Carcinogens toxicity, Aged, Lung Neoplasms mortality, Lung Neoplasms epidemiology, Occupational Exposure adverse effects, Occupational Exposure statistics & numerical data, Occupational Diseases mortality, Occupational Diseases epidemiology
Abstract: Objective: The aim of this study was to analyse the attributable risk of mortality and DALYs (Disability Adjusted Life Years) due to occupational carcinogens for lung cancer between 1990 and 2019 in Brazil and federation units, as well as its relationship with the Socio-demographic Index (SDI)., Study Design: Epidemiological study., Methods: This is an epidemiological study that used GBD 2019 (Global Burden of Disease Study) estimates of lung cancer mortality rates and DALYs attributable to occupational carcinogens. The relationship between these rates and SDI was assessed using panel data analysis., Results: In Brazil, occupational exposure to asbestos, silica and diesel vapours accounted for more than 85.00% of lung cancer deaths and DALYs attributable to occupational carcinogens in both sexes between 1990 and 2019. An increase in both rates was observed in women for almost all the occupational carcinogens assessed, especially in the North and Northeast regions of the country, with diesel vapours standing out the most., Conclusions: The present study highlighted the urge to characterise exposure to occupational risks for lung cancer, especially for the female population in the North and Northeast regions of Brazil., (Copyright © 2024 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.)
Published: 2024
Full Text: View/download PDF

19. [Survival rate of laryngeal cancer patients treated in Brazil's Unified Health System - SUS, 2002-2010].

Author: Candido TC, Teixeira MTB, Nogueira MC, Cherchiglia ML, and Guerra MR
Subjects: Humans, Brazil epidemiology, Male, Middle Aged, Retrospective Studies, Female, Aged, Survival Rate, Adult, Cohort Studies, National Health Programs organization & administration, Time Factors, Young Adult, Aged, 80 and over, Delivery of Health Care, Laryngeal Neoplasms mortality, Laryngeal Neoplasms therapy
Abstract: The scope of this article was to analyze the five-year survival rate among patients with laryngeal cancer treated in the Unified Health System in Brazil and its regions between January 2002 and June 2010. There is still scarce information in Brazil regarding the scale and survival rate of laryngeal cancer patients, which makes it difficult to adopt specific strategies for the control of the condition in the country. A retrospective cohort study based on the National Oncology Database was conducted, and the survival probability rate for laryngeal cancer according to age, sex and Brazilian regions/states was estimated using the Kaplan-Meier method. The log-rank test was used to assess the differences observed, considering a 5% significance level. Survival in Brazil was estimated at 50.8% (95%CI: 49.9%-51.8%), being lower among male patients (49.1%; 95%CI: 48.10%-50.16%); between 50 and 60 years of age (48.4%; 95%CI: 46.7%-50.0%); for residents of the Northern region (45.5%; 95%CI: 39.5%-51.3%). The regional variation in the survival rate for laryngeal cancer in Brazil reveals disparities between Brazilian regions/states that may be linked to inequality of access to diagnosis and/or treatment.
Published: 2024
Full Text: View/download PDF

20. No Differences in Clinical Outcomes Between Hip Arthroscopy With Versus Without Capsular Closure in Patients With Cam- or Mixed-Type Femoroacetabular Impingement: A Randomized Controlled Trial.

Author: Bonin N, Manzini F, and Viamont-Guerra MR
Subjects: Humans, Female, Male, Adult, Treatment Outcome, Young Adult, Hip Joint surgery, Prospective Studies, Follow-Up Studies, Reoperation statistics & numerical data, Femoracetabular Impingement surgery, Arthroscopy methods, Joint Capsule surgery
Abstract: Purpose: To compare 2-year clinical outcomes of primary hip arthroscopy with versus without capsular closure after interportal capsulotomy in patients with cam- or mixed-type femoroacetabular impingement (FAI)., Methods: Patients with cam- or mixed-type FAI undergoing primary hip arthroscopy with interportal capsulotomy were prospectively enrolled in this randomized controlled trial (RCT) and allocated into either capsular closure or no capsular closure groups. Patients were blinded to group allocation. Clinical outcomes were assessed preoperatively and at 2-year follow-up using the 12-item International Hip Outcome Tool (iHOT-12), modified Harris Hip Score (mHHS), and 6 subsections of the Copenhagen Hip and Groin Outcome Score (HAGOS). Complications and reoperations were noted., Results: Eighty-four patients (100 hips) were enrolled, 49 hips in the capsular closure group and 51 in the no capsular closure group, with no significant differences in age (28.5 ± 7.5 vs 30.4 ± 8.4, P = .261), body mass index (23.5 ± 3.0 vs 23.4 ± 1.9, P = .665), and sex distribution (female: 10.2% vs 13.7%, P = .760). Four patients were lost to follow-up (2.0% vs 5.9%, P = .618) and 6 had reoperations (6.1% vs 5.9%, P = 1.000), which left 45 hips per group for clinical assessment. There were no significant differences between groups in the net change of iHOT-12 (28.3 ± 19.6 vs 32.5 ± 22.7, P = .388), mHHS (7.6 ± 13.1 vs 7.5 ± 10.2, P = .954), and subsections of HAGOS (P > .05). Complication rates were also similar between groups (P > .05)., Conclusions: The present RCT compared primary hip arthroscopy with versus without capsular closure after interportal capsulotomy in a male-dominated, non-dysplastic, non-arthritic cohort with cam- or mixed-type FAI and found no significant differences in patient-reported clinical outcomes, complication rates, or reoperation rates., Level of Evidence: Level I, randomized controlled trial., (Copyright © 2024 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.)
Published: 2024
Full Text: View/download PDF

21. Ultra-early versus early surgery for hip fracture.

Author: Viamont-Guerra MR, Guimarães R, Bridges C, Antonioli E, and Lenza M
Subjects: Humans, Randomized Controlled Trials as Topic, Systematic Reviews as Topic, Time-to-Treatment, Time Factors, Adult, Hip Fractures surgery
Abstract: Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects (benefits and harms) of ultra-early versus early surgery for hip fracture in adults., (Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.)
Published: 2024
Full Text: View/download PDF

22. Satisfactory mid-term clinical outcomes of endoscopic tenotomy for iliopsoas tendinopathy following total hip arthroplasty.

Author: Erard J, Viamont-Guerra MR, and Bonin N
Subjects: Humans, Male, Female, Middle Aged, Aged, Treatment Outcome, Endoscopy methods, Retrospective Studies, Postoperative Complications etiology, Postoperative Complications surgery, Tenotomy methods, Tendinopathy surgery, Tendinopathy etiology, Arthroplasty, Replacement, Hip adverse effects, Arthroplasty, Replacement, Hip methods, Psoas Muscles surgery
Abstract: Purpose: To report 5-year outcomes of endoscopic iliopsoas tenotomy in patients with iliopsoas tendinopathy following total hip arthroplasty (THA) and determine whether clinical scores are associated with cup position., Methods: Patients who underwent endoscopic iliopsoas tenotomy for iliopsoas tendinopathy following THA (2014-2017) were contacted. Indications for endoscopic iliopsoas tenotomy after THA were groin pain during active hip flexion, exclusion of other causes of groin pain, and no pain relief after 6 months of conservative treatment. Pretenotomy cup inclination and anteversion were measured on radiographs; axial and sagittal cup overhang were measured on computed tomography (CT) scans. Oxford hip score (OHS), modified Harris hip score (mHHS), and groin pain were assessed., Results: The initial cohort comprised 16 men (17 hips) and 31 women (32 hips), aged 60.7 ± 10.6 years. Cup inclination and anteversion were, respectively, 46.2 ± 6.2° and 14.6 ± 8.4°, while axial and sagittal cup overhang were, respectively, 4.4 ± 4.0 mm and 6.9 ± 4.5 mm. At ≥5 years follow-up, four hips underwent cup and stem revision, two underwent isolated cup revision and one underwent secondary iliopsoas tenotomy. OHS improved by 23 ± 10 and mHHS improved by 31 ± 16. Posttenotomy groin pain was slight in 20.0%, mild in 17.5% and moderate in 12.5%. Regression analyses revealed that net change in mHHS decreased with sagittal cup overhang (β = -3.1; 95% confidence interval [CI] = -4.6 to -1.7; p < 0.001), but that there were no associations between cup position and net change in OHS., Conclusions: Endoscopic iliopsoas tenotomy provides good mid-term clinical outcomes in patients with iliopsoas tendinopathy following THA. Furthermore, improvements in mHHS were found to decrease with increasing sagittal cup overhang, in cases for which adequate preoperative imaging was available., Level of Evidence: Level IV., (© 2024 European Society of Sports Traumatology, Knee Surgery and Arthroscopy.)
Published: 2024
Full Text: View/download PDF

23. Quality of life of women who underwent breast cancer treatment relative to sociodemographic, behavioral, and clinical factors.

Author: Campos AAL, Bustamante-Teixeira MT, Ervilha RR, Fayer VA, Cintra JRD, Freitas RM, Almeida DP, and Guerra MR
Subjects: Humans, Female, Cross-Sectional Studies, Surveys and Questionnaires, Survivors, Quality of Life psychology, Breast Neoplasms drug therapy
Abstract: Objective: Patients with cancer often undergo multiple extended treatments that decrease their quality of life. However, the quality of life of women with breast cancer after they undergo treatment remains underexplored in Brazil. Therefore, this study determined sociodemographic, behavioral, and clinical factors related to the post-treatment quality of life of women with breast cancer., Methods: This cross-sectional study involved 101 women diagnosed with breast cancer between 2014 and 2016 and treated at a Brazilian Oncology Reference Service. Data were collected from them using face-to-face surveys. Quality of life was evaluated using the European Organization for the Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) and EORTC Breast Cancer-specific Quality of Life questionnaire (EORTC QLQ-BR23). The data collected were analyzed using Student's t-test and Mann-Whitney U test., Results: The median score on the global health, functional, and symptom scales of the EORTC QLQ-C30 was 75.00 (Interquartile range=33.33), 75.99 (Standard deviation [SD]=19.26), and 19.67 (SD=16.91), respectively. The mean score on the functional and symptom scales of the EORTC QLQ-BR23 was 61.89 (SD=17.21) and 20.12 (SD=16.94), respectively. Furthermore, higher post-treatment quality of life was found to be associated with being aged 50 or more, being Black, having eight or more years of education, having a partner, having a paying job, receiving treatment from the private healthcare system, having a higher income, living in the municipality where healthcare services are availed, engaging in physical activity, not smoking, being more religious, having more social support, not being overweight, having no comorbidities, and undergoing lumpectomy., Conclusion: Sociodemographic, behavioral, and clinical factors significantly impact the quality of life of women who undergo breast cancer treatment. Implementing interventions that improve health and reducing inequalities in the access to healthcare services can improve the quality of life of these patients., Background: Sociodemographic, clinical, and lifestyle factors impact the quality of life of breast cancer survivors., Background: Breast cancer therapy may affect future perspectives and emotional, cognitive, and sexual function., Background: Some aspects of quality of life still require attention from health professionals., Background: Higher post-treatment quality of life of women with breast cancer is linked to being aged 50 or more, being Black, having 8 or more years of education, having a partner, having a paying job, receiving care from private healthcare, having a high per capita income, residing in the municipality where the service is availed, engaging in physical activity, not smoking, greater religiosity, having more social support, having a normal weight, having no comorbidities, and undergoing lumpectomy.
Published: 2024
Full Text: View/download PDF

24. Proton pump inhibitors and cardiovascular risk: a critical review.

Author: Duarte GJ, Lopez J, Sosa F, Molina G, Shaban M, Mark J, Khizar A, Sreenivasan A, Tran A, and Guerra MR
Subjects: Humans, Risk Assessment methods, Heart Disease Risk Factors, Gastrointestinal Diseases chemically induced, Drug Interactions, Risk Factors, Proton Pump Inhibitors adverse effects, Cardiovascular Diseases chemically induced
Abstract: Proton pump inhibitors (PPI) are widely used medications for gastrointestinal disorders. Recent research suggests a potential association between long-term PPI use and increased cardiovascular (CV) risk, creating a complex clinical dilemma. This review critically evaluates the current evidence for this association, considering the limitations of observational studies and the lack of definitive confirmation from randomized controlled trials.This review delves into the reported association between PPIs and adverse CV events, examining proposed mechanisms such as drug interactions, electrolyte imbalances induced by PPIs and their potential impact on cardiac and vascular function. Evidence suggests these mechanisms converge, with varying influence depending on patient populations.Clinicians require a risk-benefit analysis for each patient considering their CV risk profile. Alternative gastrointestinal therapies should be explored for high-bleeding risk patients. Medications with lower cytochrome-P450 interaction potential may be preferable among essential PPI users. Elucidating the specific mechanisms by which PPIs might influence CV health, assessing long-term vascular effects and investigating interactions with newer anticoagulant medications are crucial for future research.
Published: 2024
Full Text: View/download PDF

25. Satisfactory clinical and radiographic outcomes following revision total hip arthroplasty by direct anterior approach using primary femoral stems at 2-8 years of follow-up.

Author: Viamont-Guerra MR, Ramos-Pascual S, Saffarini M, and Laude F
Subjects: Humans, Follow-Up Studies, Treatment Outcome, Reoperation, Hypertrophy, Prosthesis Design, Arthroplasty, Replacement, Hip, Hip Prosthesis, Osteolysis diagnostic imaging, Osteolysis etiology, Osteolysis surgery
Abstract: Introduction: To report clinical and radiographic outcomes of revision total hip arthroplasty (THA) through the direct anterior approach (DAA) using primary stems., Materials and Methods: The authors assessed a consecutive series of revision THAs operated by DAA using primary (cemented and uncemented) stems between 1/1/2010 and 30/06/2017. The initial cohort comprised 47 patients (50 hips), aged 65 ± 10 years with BMI of 25 ± 4 kg/m 2 . Clinical assessment included modified Harris Hip Score (mHHS) and satisfaction with surgery. Radiographic assessment included radiolucent lines > 2 mm, bone remodelling, cortical hypertrophy, pedestal formation, and osteolysis. Linear regression analyses were performed., Results: Of the 50 hips (47 patients) in the initial cohort, intraoperative complications that did not require re-revision occurred in 5 hips. At a follow-up of > 2 years: 5 hips (10%) were lost to follow-up and 3 hips (6%) required stem re-revision, leaving a final cohort of 42 hips (40 patients). Postoperative complications that did not require re-revision occurred in 4 hips (8%). At 4.3 ± 1.6 years, post-revision mHHS was 89 ± 14 (range 47-100) and 38 patients were satisfied or very satisfied with revision surgery. Bone remodelling was observed in 8 hips (16%), cortical hypertrophy in 6 hips (12%), grade I heterotopic ossification in 7 hips (14%), and grade II in 1 hip (2%). There were no cases of radiolucent lines, pedestal formation, or osteolysis. Regression analyses revealed that post-revision mHHS was not associated with any variable., Conclusions: Revision THA performed through the DAA using primary stems grants satisfactory clinical and radiographic outcomes at a minimum follow-up of two years., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Published: 2023
Full Text: View/download PDF

26. Modified U Slot Patch Antenna with Large Frequency Ratio for Vehicle-to-Vehicle Communication.

Author: Govindarajulu SR, Tarek MNA, Guerra MR, Hassan A, and Alwan E
Subjects: Equipment Design, Communication, Wireless Technology, Commerce
Abstract: This paper presents a single-fed, single-layer, dual-band antenna with a large frequency ratio of 4.74:1 for vehicle-to-vehicle communication. The antenna consists of a 28 GHz inset-fed rectangular patch embedded into a 5.9 GHz patch antenna for dual-band operation. The designed dual-band antenna operates from 5.81 to 5.99 GHz (Dedicated Short Range Communications, DSRC) and 27.9 to 30.1 GHz (5G millimeter-wave (mm-wave) band). Furthermore, the upper band patch was modified by inserting slots near the inset feed line to achieve an instantaneous bandwidth of 4.5 GHz. The antenna was fabricated and measured. The manufactured prototype operates simultaneously from 5.8 to 6.05 GHz and from 26.8 to 31.3 GHz. Notably, the designed dual-band antenna offers a high peak gain of 7.7 dBi in the DSRC band and 6.38 dBi in the 5G mm-wave band.
Published: 2023
Full Text: View/download PDF

27. Identification of Chlamydia trachomatis genotypes in newborns with respiratory distress.

Author: González-Fernández MD, Escarcega-Tame MA, López-Hurtado M, Flores-Salazar VR, Escobedo-Guerra MR, Giono-Cerezo S, and Guerra-Infante FM
Subjects: Humans, Infant, Newborn, Female, Pregnancy, Chlamydia trachomatis genetics, Genotype, Chorioamnionitis, Neonatal Sepsis, Chlamydia Infections diagnosis, Chlamydia Infections epidemiology, Respiratory Tract Infections
Abstract: Introduction: One hundred thirty million Chlamydia trachomatis infections are reported worldwide each year. Nineteen serotypes of this pathogen can cause infection in pregnant women and neonates. The distribution of these genotypes in newborns with respiratory infections in Mexico is unknown., Material and Methods: We tested 1062 bronchial lavage samples from neonates with respiratory distress syndrome for Chlamydia infection. The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene., Results: The genotyping of 40 strains identified 14 as I/Ia (35%), 13 as E (32.5%), 7 as D (17.5%), 5 as F (12.5%), and 1 as L2 (2.5%). The relative risk analysis showed that genotype D was associated with neonatal sepsis (RR, 5.83; 95% confidence interval [CI], 1.51-25.985; P < .02), while the I/Ia genotype was significantly associated with chorioamnionitis in the mother (2.8; 95% CI, 1.4-5.5; P < .05)., Conclusions: Although C. trachomatis genotypes I/Ia and E of were the strains involved most frequently in respiratory infections in Mexican neonates, 80% of patients with genotype F developed respiratory disease. In contrast, genotype D was associated with neonatal sepsis, and genotype I/Ia with chorioamnionitis., (Copyright © 2023 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved.)
Published: 2023
Full Text: View/download PDF

28. Breast cancer survival and the health system in Brazil: an analysis of public and private healthcare.

Author: Ferreira ASS, Cintra JRD, Fayer VA, Nogueira MC, Júnior CB, Bustamante-Teixeira MT, Chaoubah A, Cintra AD, Simão CM, and Guerra MR
Abstract: Background: The incidence of breast cancer is increasing globally; however, survival outcomes vary and are lower in developing countries., Methods: We analyzed the 5- and 10-year survival rates for breast cancer according to the type of healthcare insurance (public vs . private) in a referral center for cancer care in the Brazilian southeast region. This hospital-based cohort study included 517 women diagnosed with invasive breast cancer between 2003 and 2005. The Kaplan-Meier method was used to estimate the probability of survival, and the Cox proportional hazards regression model was used to assess prognostic factors., Results: The 5- and 10-year breast cancer survival rates were as follows: private healthcare service survival rate of 80.6% (95% CI 75.0-85.0) and 71.5% (95% CI 65.4-77.1), respectively, and public healthcare service survival rate of 68.5% (95% CI 62.5-73.8) and 58.5% (95% CI 52.1-64.4), respectively. The main factors associated with the worst prognosis were lymph node involvement in both healthcare services and tumor size >2 cm only in public health services. The use of hormone therapy (private) and radiotherapy (public) was associated with the best survival rates., Conclusions: The survival discrepancies found between health services can be explained mainly by the difference in the stage of the disease at the time of diagnosis, indicating inequalities in access to the early detection of breast cancer., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Ferreira, Cintra, Fayer, Nogueira, Júnior, Bustamante-Teixeira, Chaoubah, Cintra, Simão and Guerra.)
Published: 2023
Full Text: View/download PDF

29. The American College of Surgeons National Surgical Quality Improvement Program surgical risk calculator is not reliable in predicting complications and length of stay after primary total hip arthroplasty at an institution implementing clinical pathways.

Author: Manhabusqui Pacífico G Jr, Viamont-Guerra MR, Antonioli E, Paião ID, Saffarini M, and Pereira Guimarães R
Subjects: Humans, United States, Aged, Length of Stay, Risk Assessment, Retrospective Studies, Quality Improvement, Critical Pathways, Reproducibility of Results, Postoperative Complications epidemiology, Postoperative Complications etiology, Risk Factors, Arthroplasty, Replacement, Hip adverse effects, Surgeons, Hypertension complications
Abstract: Introduction: The authors aimed to: (1) determine how length of stay (LOS) and complication rates changed over the past 10 years, in comparison to values estimated by the ACS-NSQIP surgical risk calculator, at a single private institution open to external surgeons; and (2) determine preoperative patient factors associated with complications., Methods: We retrospectively assessed 1018 consecutive patients who underwent primary elective THA over 10 years. We excluded 87 with tumours and 52 with incomplete records. Clinical data of the remaining 879 were used to determine real LOS and rate of 9 adverse events over time, as well as to estimate these values using the risk calculator. Its predictive reliability was represented on receiver operating characteristic curves. Multivariable analyses were performed to determine associations of complications with age, sex, ASA score, diabetes, hypertension, heart disease, smoking and BMI., Results: Over the 10-year period, real LOS and real complication rates decreased considerably, while LOS and complication rates estimated by the surgical risk calculator had little or no change. The difference between real and estimated LOS decreased over time. The overall estimated and real rates of any complication were respectively 3.3% and 2.8%. The risk calculator had fair reliability for predicting any complications (AUC 0.72). Overall estimated LOS was shorter than the real LOS in 764 (86.9%) patients. Multivariable analysis revealed risks of any complication to be greater in patients aged ⩾75 (OR = 4.36, p = 0.002), and with hypertension (OR = 3.13, p = 0.016)., Conclusions: Since the implementation of clinical pathways at our institution, real LOS and complication rates decreased considerably, while LOS and complication rates estimated by the surgical risk calculator had little or no change. The difference between real and estimated LOS decreased over time, which could lead some clinicians to reconsider their discharge criteria, knowing that advanced age and hypertension increased risks of encountering complications.
Published: 2023
Full Text: View/download PDF

30. Effect of femoral stem surface coating on clinical and radiographic outcomes of cementless primary total hip arthroplasty: a patient-matched retrospective study.

Author: Viamont-Guerra MR, Ramos-Pascual S, Saffarini M, Sales J, and Laude F
Subjects: Humans, Retrospective Studies, Durapatite, Hypertrophy, Prosthesis Design, Follow-Up Studies, Treatment Outcome, Reoperation, Arthroplasty, Replacement, Hip adverse effects, Arthroplasty, Replacement, Hip methods, Hip Prosthesis adverse effects, Osteolysis
Abstract: Purpose: This study aims to determine whether changing the stem coating grants superior outcomes at a minimum follow-up of five years., Methods: Retrospective review of a consecutive series of primary total hip arthroplasties (THAs) operated by direct anterior approach between 01/01/2013 and 31/12/2014. Two stems were compared, which were identical except for their surface coating; "the Original stem" was fully coated with hydroxyapatite (HA), while "the ProxCoat stem" was proximally coated with plasma-sprayed titanium and HA. Matching was performed. Clinical assessment included modified Harris hip score (mHHS), Oxford hip score (OHS), and forgotten joint score (FJS). Radiographic assessment evaluated alignment, subsidence, pedestal formation, heterotopic ossification, radiolucent lines ≥ 2 mm, spot welds, cortical hypertrophy, and osteolysis., Results: 232 hips received the Original stem and 167 the ProxCoat stem, from which respectively five hips (2.2%) and no hips (0%) underwent revision. Matching identified two groups of 91 patients, with comparable patient demographics. At > five years follow-up, there were no differences in OHS (16 ± 6 vs 15 ± 5; p = 0.075) nor FJS (81 ± 26 vs 84 ± 22; p = 0.521), but there were differences in mHHS (89 ± 15 vs 92 ± 12; p = 0.042). There were no differences in alignment, subsidence, pedestal formation, heterotopic ossification, cortical hypertrophy, and osteolysis. There were differences in prevalence of proximal radiolucent lines (12% vs 0%; p < 0.001) and distal spot welds (24% vs 54%; p < 0.001)., Conclusion: At a minimum follow-up of five years, this study on matched patients undergoing primary THA found that ProxCoat stems results in significantly fewer radiolucent lines, more spot welds, and less revisions than Original stems, thus suggesting better bone ingrowth., (© 2022. The Author(s) under exclusive licence to SICOT aisbl.)
Published: 2023
Full Text: View/download PDF

31. TOTAL HIP ARTHROPLASTY IN THE PUBLIC HEALTH SYSTEM OF SÃO PAULO: COMPARING TYPES OF FIXATION.

Author: Guimarães RP, Viamont-Guerra MR, Antonioli E, and Lenza M
Abstract: Brazil lacks registries on the prevalence of primary total hip arthroplasty (THA) fixation methods., Objective: (i) to describe the demographic profile of patients who underwent THA in the public health system of the municipality of São Paulo during the last 12 years and (ii) to compare fixation methods regarding costs, hospital stay length, and death rates., Methods: This is an ecological study conducted with data available on TabNet, a platform belonging to DATASUS. Public data (from the government health system) on THA procedures performed in São Paulo from 2008 to 2019 were extracted. Gender, age, city region, THA fixation method, number of surgeries, costs, hospital stay length, and death rates were analyzed., Results: We analyzed 7,673 THA, of which 6220 (81%) were performed via cementless/hybrid fixation and 1453 (19%), via the cemented technique. Cementless/hybrid fixation had a higher cost (US$ 495.27) than the cemented one (p < 0.001). Nevertheless, hospital stay length was 0.87 days longer for cemented fixation than the cementless/hybrid one. We found no significant difference in death rates between THA fixation methods., Conclusion: THA cementless/hybrid fixation is prevalent in the municipality of São Paulo, which had higher total costs and shorter hospitalizations than cemented fixation. We found no difference between THA fixation methods and death rates. Level of Evidence IV, Case Series., Competing Interests: All authors declare no potential conflict of interest related to this article.
Published: 2022
Full Text: View/download PDF

32. Temporal trends in social security benefits for female breast cancer in Brazil.

Author: Girardi FA, Nogueira MC, Bustamante-Teixeira MT, and Guerra MR
Subjects: Brazil epidemiology, Female, Humans, Sick Leave, Social Security, Breast Neoplasms epidemiology, Persons with Disabilities
Abstract: The aim of this study was to assess temporal trends in disability benefits for breast cancer awarded to women by Brazil's National Social Security Institute. We conducted a time-series analysis of disability benefit incidence rates between 2007 and 2018 using joinpoint regression and data from the Unified Benefits Information System (SUIBE) and open access social security system database. The age-adjusted incidence rate increased by 6.7% per year between 2015 and 2018 after a period of stability between 2007 and 2014. The number of benefits granted to women aged 20-49 increased, on average, by 3.4% per year, showing a marked rise from 2015 to 2018 (10.4% per year). The findings highlight that breast cancer is an important cause of sick leave among female workers and that the incidence of the disease is growing in younger economically active women, reinforcing the importance of early referral to the Social Security Professional Rehabilitation Program to help workers return to work and readapt to working life.
Published: 2022
Full Text: View/download PDF

33. Histological and Immunohistochemical Characteristics for Hereditary Breast Cancer Risk in a Cohort of Brazilian Women.

Author: de Freitas RM, Guerra MR, Fayer VA, Campos AAL, Cintra JRD, Warren J, Ervilha RR, de Paula CD, and Bustamante-Teixeira MT
Subjects: Brazil epidemiology, Female, Genetic Predisposition to Disease, Humans, Retrospective Studies, Breast Neoplasms epidemiology, Breast Neoplasms genetics, Breast Neoplasms pathology, Ovarian Neoplasms genetics
Abstract: Objective: The study aimed to characterize the clinical, histological, and immunohistochemical profile of women with invasive breast cancer, according to the risk for Hereditary Predisposition Breast and Ovarian Cancer Syndrome in a Brazilian population., Methods: This is a retrospective study performed from a hospital-based cohort of 522 women, diagnosed with breast cancer treated at an oncology referral center in the Southeast region of Brazil, between 2014 and 2016., Results: Among the 430 women diagnosed with invasive breast cancer who composed the study population, 127 (29.5%) were classified as at increased risk for hereditary predisposition to breast and ovarian cancer syndrome. There was a lower level of education in patients at increased risk (34.6%) when compared with those at usual risk (46.0%). Regarding tumor characteristics, women at increased risk had higher percentages of the disease diagnosed at an advanced stage (32.3%), and with tumors > 2cm (63.0%), with increased prevalence for both characteristics, when compared with those at usual risk. Furthermore, we found higher percentages of HG3 (43.3%) and K i -67 ≥ 25% (64.6%) in women at increased risk, with prevalence being about twice as high in this group. The presence of triple-negative tumors was observed as 25.2% in women at increased risk and 6.0% in women at usual risk, with the prevalence of absence of biomarkers being 2.5 times higher among women in the increased risk group., Conclusion: From the clinical criteria routinely used in the diagnosis of breast cancer, the care practice of genetic counseling for patients at increased risk of hereditary breast cancer in contexts such as Brazil is still scarce., Competing Interests: The authors have no conflict of interests to declare., (Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).)
Published: 2022
Full Text: View/download PDF

34. Identification of Chlamydia trachomatis genotypes in Mexican men with infertile women as sexual partners.

Author: López-Hurtado M, Escarcega-Tame MA, Escobedo-Guerra MR, de Haro-Cruz MJ, and Guerra-Infante FM
Subjects: Chlamydia trachomatis genetics, Female, Genotype, Humans, Male, Mexico epidemiology, Sexual Partners, Chlamydia Infections complications, Chlamydia Infections epidemiology, Infertility, Female
Abstract: Background: Chlamydia trachomatis is considered a public health problem due to the high prevalence in sexually active women and men. The distribution of genital Chlamydia genotypes among Mexican men is unknown., Objective: To assess the prevalence of Chlamydia genotypes in men with infertile women as sexual partners., Methods: A total of 659 urine samples were collected from men whose sexual partners were infertile women; the identifying Chlamydia infection was by means of a real-time nucleic acid amplification test (qPCR). OmpA gene PCR-RFLP and sequencing were used to confirm the genotypes of C. trachomatis. The association of genotypes with age, spermatic parameters and gynecological data of sexual partners was further analyzed., Results: Forty-nine urine samples were positive infection (7.4%). The Chlamydia infection was significantly associated with teratozoospermia, azoospermia, hypospermia, and oligozoospermia. Five genotypes (F 51%; 12.2% to D; 12.2% to E; 6.1% to L2 and 4.1% Ia) were correctly identified. None genotypes identified in this comparative study were positively associated with changes in some of the spermatic values because all of them typically produce some considerable damage to these cells., Conclusions: The F genotype was the most frequent genotype identified in infertile men from Mexico City and all genotypes play an important role in the seminal alteration of Mexican men whose female partners are infertile., (Copyright © 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved.)
Published: 2022
Full Text: View/download PDF

35. Time to diagnosis and treatment for breast cancer in public and private health services.

Author: Campos AAL, Guerra MR, Fayer VA, Ervilha RR, Cintra JRD, Medeiros IR, Silveira MCD, and Bustamante-Teixeira MT
Subjects: Brazil, Female, Humans, Retrospective Studies, Breast Neoplasms diagnosis, Breast Neoplasms therapy
Abstract: Objective: To analyze the time to diagnosis and treatment for breast cancer and the associated factors, according to the type of care (public vs. private)., Methodology: Retrospective cohort study with 477 women diagnosed with breast cancer between 2014 and 2016. Data were collected in an oncology service in a municipality in Minas Gerais, in the 2018-2019 period. Analyzes were performed using the Kaplan-Meier method and Cox's proportional regression model., Results: The median time to diagnosis was 70 days, being shorter for women who discovered the disease through screening tests and who were diagnosed in early stages of the disease. The median time for treatment was 32 days, which was shorter for women assisted by private health service, with a high level of education and who were diagnosed in early stages., Conclusions: Private care and facilitators of access to breast cancer care were associated with shorter waiting times.
Published: 2022
Full Text: View/download PDF

36. Soft Tissue Hybrid Model for Real-Time Simulations.

Author: Moreno-Guerra MR, Martínez-Romero O, Palacios-Pineda LM, Olvera-Trejo D, Diaz-Elizondo JA, Flores-Villalba E, da Silva JVL, Elías-Zúñiga A, and Rodriguez CA
Abstract: In this article, a recent formulation for real-time simulation is developed combining the strain energy density of the Spring Mass Model (SMM) with the equivalent representation of the Strain Energy Density Function (SEDF). The resulting Equivalent Energy Spring Model (EESM) is expected to provide information in real-time about the mechanical response of soft tissue when subjected to uniaxial deformations. The proposed model represents a variation of the SMM and can be used to predict the mechanical behavior of biological tissues not only during loading but also during unloading deformation states. To assess the accuracy achieved by the EESM, experimental data was collected from liver porcine samples via uniaxial loading and unloading tensile tests. Validation of the model through numerical predictions achieved a refresh rate of 31 fps (31.49 ms of computation time for each frame), achieving a coefficient of determination R 2 from 93.23% to 99.94% when compared to experimental data. The proposed hybrid formulation to characterize soft tissue mechanical behavior is fast enough for real-time simulation and captures the soft material nonlinear virgin and stress-softened effects with high accuracy.
Published: 2022
Full Text: View/download PDF

37. The increasing burden of pancreatic cancer in Brazil from 2000 to 2019: estimates from the Global Burden of Disease Study 2019.

Author: Chaves DO, Bastos AC, Almeida AM, Guerra MR, Teixeira MTB, Melo APS, and Passos VMA
Subjects: Aged, Brazil epidemiology, China epidemiology, Humans, Incidence, Global Burden of Disease, Pancreatic Neoplasms epidemiology
Abstract: Introduction: Pancreatic cancer is increasing worldwide. The burden of pancreatic cancer in Brazil and its states was analyzed and compared with that from the USA and China., Methods: This is a descriptive study of the incidence and mortality estimates from the Global Burden of Disease 2019 study, from 2000 to 2019. The Brazilian states presenting the highest and lowest socio-demographic index (SDI) were selected from each of the five regions. The SDI consists of the per capita income, education, and fertility rate of each population., Results: A significant increase was found in age-standardized incidence and mortality of pancreatic cancer in all three countries, with differences in magnitude and annual increases. In Brazil, this incidence rose from 5.33 [95% Uncertainty Interval (UI): 5.06- 5.51] to 6.16 (95% UI: 5.68- 6.53) per 100,000 inhabitants. China and the Brazilian states with the lowest SDI, such as Pará and Maranhão, showed lower incidence and mortality rates, although presenting the highest annual increases. No difference was found between the sexes. A higher mortality rate was observed for those individuals of 70+ years, which was three to four times higher than those aged 50 to 69 years., Conclusions: The increasing burden of pancreatic cancer in the studied countries, and the higher estimates for the elderly in a fast-aging country such as Brazil, indicates that more resources and health policies will be necessary. The greatest increase in the states with lower SDI reflects inequalities in the access to diagnosis and registries of this cancer.
Published: 2022
Full Text: View/download PDF

38. Trend of the Burden of Larynx Cancer in Brazil, 1990 to 2019.

Author: Viana LP, Bustamante-Teixeira MT, Malta DC, Silva GAE, Mooney M, Naghavi M, Nogueira MC, Passos VMA, and Guerra MR
Subjects: Brazil epidemiology, Female, Humans, Incidence, Male, Prognosis, Risk Factors, Laryngeal Neoplasms epidemiology
Abstract: Introduction: Larynx cancer is one of the most common head and neck cancers, whose main risk factors are smoking and alcohol use, and its occurrence and prognosis depend on adequate and timely preventive measures. This study aimed to investigate the burden of larynx cancer in Brazil and its states., Methods: Using estimates from the Global Burden of Disease Study 2019, this study analyzed the trends of incidence, mortality, and disability-adjusted life years (DALYs) for larynx cancer between 1990 and 2019, besides the mortality-to-incidence ratio and the socio demographic index., Results: Incidence and mortality due to larynx cancer in Brazil, which are approximately eight-fold higher for men, showed a declining trend between 1990 and 2019 (APPC: -0.4% and -1.0%, respectively). The DALYs also showed negative variation between 1990 and 2019 for both sexes in Brazil, mainly due to the decrease in premature deaths, with the greatest reduction in the state of São Paulo. For the states of Brazil in 2019, the higher age-standardized incidence rate (Rio Grande do Sul, 3.83 cases per 100,000 inhabitants) is twice the lowest rate (Piauí, 1.56 cases per 100,000 inhabitants)., Conclusions: A fall in the burden of larynx cancer was observed in Brazil over the past 30 years, which may be attributed to a reduction in smoking and to an improvement in treatment. However, the regional inequalities in the country remain evident, especially for males. This data can guide public policy priorities to control the disease in Brazil.
Published: 2022
Full Text: View/download PDF

39. Differential cytokine and chemokine expression during rejection and infection following intestinal transplantation.

Author: Whang EC, Rossetti M, Guerra MR, Cheng E, Marcus EA, McDiarmid SV, Venick RS, Farmer DG, Reed EF, and Wozniak LJ
Subjects: Chemokines, Cross-Sectional Studies, Humans, Prospective Studies, Cytokines, Graft Rejection diagnosis
Abstract: Background/objectives: Rejection and infectious enteritis in intestinal transplant (ITx) patients present with virtually identical symptoms. Currently, the gold standard for differentiating between these two conditions is endoscopy, which is invasive and costly. Our primary aim was to identify differences in peripheral blood cytokines during episodes of acute cellular rejection (ACR) and infectious enteritis in patients with intestinal transplants., Methods: This was a prospective, cross-sectional study involving ITx patients transplanted between 2000 and 2016. We studied 63 blood samples collected from 29 ITx patients during periods of normal (n = 24) and abnormal (n = 17) allograft function. PBMCs from whole blood samples were cultured under unstimulated or stimulated conditions with phytohemagglutinin (PHA). The supernatant from these cultures were collected to measure cytokine and chemokine levels using a 38-plex luminex panel., Results: Our study found that cytokines and chemokines are differentially expressed in normal, ACR, and infectious enteritis samples under unstimulated conditions based on heatmap analysis. Although each cohort displayed distinctive signatures, only MDC (p = 0.037) was found to be significantly different between ACR and infectious enteritis. Upon stimulation of PBMCs, patients with ACR demonstrated increased immune reactivity compared to infectious enteritis; though this did not reach statistical significance., Conclusions: To our knowledge, this is the first comprehensive study comparing cytokine expression during acute rejection and infectious enteritis in intestinal transplant recipients. Our results suggest that cytokines have the potential to be used as clinical markers for risk stratification and/or diagnosis of ACR and infectious enteritis., (Published by Elsevier B.V.)
Published: 2021
Full Text: View/download PDF

40. Reply to the Letter to the Editor: Does Cup Position at the High Hip Center or Anatomic Hip Center in THA for Developmental Dysplasia of the Hip Result in Better Harris Hip Scores and Revision Incidence? A Systematic Review.

Author: Stirling P, Viamont-Guerra MR, Strom L, Chen AF, Saffarini M, Nover L, and Laude F
Subjects: Acetabulum surgery, Humans, Incidence, Arthroplasty, Replacement, Hip adverse effects, Developmental Dysplasia of the Hip, Hip Prosthesis
Abstract: Competing Interests: All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request.
Published: 2021
Full Text: View/download PDF

41. Endoscopic Tenotomy for Iliopsoas Tendinopathy Following Total Hip Arthroplasty Can Relieve Pain Regardless of Acetabular Cup Overhang or Anteversion.

Author: Viamont-Guerra MR, Ramos-Pascual S, Saffarini M, and Bonin N
Subjects: Acetabulum diagnostic imaging, Acetabulum surgery, Female, Humans, Male, Pain surgery, Retrospective Studies, Tenotomy, Arthroplasty, Replacement, Hip, Tendinopathy surgery
Abstract: Purpose: To report outcomes of endoscopic iliopsoas tenotomy (EIT) in patients with iliopsoas tendinopathy following total hip arthroplasty (THA) and determine whether improvements in clinical scores are associated with acetabular cup anteversion measured on plain radiographs or overhang measured using established and alternative computed tomography (CT)-based methods., Methods: We evaluated patients who underwent EIT for iliopsoas tendinopathy after THA (2014-2017), performed between the lesser trochanter and psoas valley. Indications were groin pain during active hip flexion, exclusion of other complications, and no pain relief after 6 months of conservative treatment. Pretenotomy inclination and anteversion were measured on radiographs; sagittal and axial overhang were measured on CT scans on slices passing through: (Method 1) prosthetic head center and (Method 2) anterior margin of acetabular cup. Modified Harris hip score (mHHS), Oxford Hip Score (OHS), and level of groin pain were recorded at 12 or more months. Wilcoxon signed-rank tests were used to compare pre- and post-tenotomy scores, and intraclass correlation coefficients (ICCs) to assess intermethod agreement., Results: The cohort comprised 16 men (17 hips) and 32 women (33 hips), aged 60.8 ± 10.5 years at EIT. For the 30 (60%) hips that had pretenotomy CT scans, axial and sagittal overhang were, respectively, 3.4 ± 3.7 mm and 4.6 ± 4.6 mm, using Method 1, compared with 3.9 ± 3.9 mm and 6.9 ± 5.0 mm using Method 2. Intermethod agreement was good for axial (ICC, 0.67; P < .001) and sagittal (ICC, 0.68; P < .001) overhang. At a minimum 1 year after EIT, 3 hips had cup and stem revision and 1 hip had isolated cup revision, leaving 46 hips for clinical assessment. No complications were noted. mHHS improved by 26 ± 19 (P < .001) and OHS improved by 20 ± 11 (P < .001). Twenty-six hips (57%) achieved the patient acceptable symptom state for mHHS, whereas 42 hips (91%) achieved the patient acceptable symptom state for OHS. Post-tenotomy groin pain was slight in 15%, mild in 17%, and moderate in 11%. Regression analyses revealed no associations between clinical scores and overhang/anteversion., Conclusions: For patients with iliopsoas tendinopathy following THA, endoscopic iliopsoas tenotomy granted clinically important improvements of mHHS in 76% and OHS in 89%, despite moderate residual groin pain in 11%. Improvements in clinical scores did not seem to be associated with the extent of cup overhang or anteversion in the cases for which adequate preoperative imaging was available., Level of Evidence: Level IV, retrospective cohort study., (Copyright © 2021 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.)
Published: 2021
Full Text: View/download PDF

42. [Chlamydia trachomatis prevalence in women from the Hospital General de Zona No. 29].

Author: Escobedo-Guerra MR, López-Hurtado M, Gutiérrez-Trujillo R, and Guerra-Infante FM
Subjects: Female, Hospitals, Humans, Pregnancy, Prevalence, Quality of Life, Chlamydia Infections diagnosis, Chlamydia Infections epidemiology, Chlamydia trachomatis genetics
Abstract: Background: Chlamydia trachomatis is the main cause of sexually transmitted bacterial infections worldwide. An estimated of 131 million cases occur each year. It is asymptomatic, but ascending infection in women can lead to pelvic inflammatory disease, ectopic pregnancy, and infertility., Objective: To determine the prevalence of C. trachomatis in open population women who attend the Hospital General de Zona No. 29., Material and Methods: Identification of C. trachomatis was carried out by PCR testing of 200 vaginal exudate samples and its genotype was determined. In parallel, a routine microbiological diagnosis was carried out., Results: The prevalence of C. trachomatis was 8.5% (17/200) with a significant concomitance of p = 0.006 with Gardnerella vaginalis (relative risk of 2.871, 95%CI: 1.574-5.236). Likewise, C. trachomatis was identified in 5 samples as the only etiological agent. Sixteen strains of C. trachomatis belong to genotype F. An identified strain of C. trachomatis presented genetic motifs similar to the Mexican variant reported in 2019., Conclusions: The prevalence of C. trachomatis in the studied population indicates the need to implement diagnostic techniques for this bacterium. The use of PCR allows a rapid genotypic determination that would explain the epidemiological behavior of C. trachomatis and would represent a significant improvement in the quality of life of the patient., (© 2021 Instituto Mexicano del Seguro Social.)
Published: 2021

43. Non-HLA AT1R antibodies are highly prevalent after pediatric intestinal transplantation.

Author: Chan AP, Guerra MR, Rossetti M, Hickey MJ, Venick RS, Marcus EA, McDiarmid SV, Farmer DG, Reed EF, and Wozniak LJ
Subjects: Adolescent, Child, Child, Preschool, Female, HLA Antigens, Humans, Male, Retrospective Studies, Young Adult, Autoantibodies blood, Intestinal Failure blood, Intestines transplantation, Receptor, Angiotensin, Type 1 immunology
Abstract: The role of angiotensin II type-1 receptor (AT1R) antibodies in intestinal transplantation (ITx) is unclear. The aims were 1) to identify the prevalence of AT1R antibodies in pediatric ITx, compared to pediatric intestinal failure (IF), and 2) to determine whether AT1R antibodies were associated with graft dysfunction. 46 serum samples from 25 ITx patients (3 isolated ITx, 22 liver-inclusive ITx) were collected during routine visits >6 months apart and during episodes of graft dysfunction as a result of infectious enteritis or rejection. For comparison, samples were collected from 7 IF control patients. AT1R antibodies were considered positive for levels >17 U/mL. The median (range) AT1R antibody level for ITx patients was 40.0 U/mL (7.2-40.0), compared to 7.0 U/mL (5.7-40.0) for IF patients (p = .02). There was a trend toward higher prevalence of AT1R antibodies in ITx compared with IF patients (68% versus 29%, p = .09). Among ITx patients, the prevalence of AT1R antibodies was not different between periods of active graft dysfunction and normal health (83% versus 67%, p = .31). For 16 patients with >2 samples, AT1R antibodies remained positive in 67% cases, developed in 14% cases, disappeared in 10% cases, and remained negative in 10% cases. The changes in AT1R antibodies did not correlate with de/sensitizing events. This is the first study of AT1R antibodies in pediatric ITx. AT1R antibodies are highly prevalent after ITx and may be triggered by immune activation associated with the transplant. However, their pathogenicity and clinical utility remain in question., (© 2021 Wiley Periodicals LLC.)
Published: 2021
Full Text: View/download PDF

44. Does Cup Position at the High Hip Center or Anatomic Hip Center in THA for Developmental Dysplasia of the Hip Result in Better Harris Hip Scores and Revision Incidence? A Systematic Review.

Author: Stirling P, Viamont-Guerra MR, Strom L, Chen AF, Saffarini M, Nover L, and Laude F
Subjects: Acetabulum diagnostic imaging, Acetabulum physiopathology, Adult, Arthroplasty, Replacement, Hip adverse effects, Biomechanical Phenomena, Developmental Dysplasia of the Hip diagnostic imaging, Developmental Dysplasia of the Hip physiopathology, Female, Hip Joint diagnostic imaging, Hip Joint physiopathology, Humans, Male, Middle Aged, Postoperative Complications diagnostic imaging, Postoperative Complications physiopathology, Postoperative Complications surgery, Range of Motion, Articular, Recovery of Function, Reoperation, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Acetabulum surgery, Arthroplasty, Replacement, Hip instrumentation, Developmental Dysplasia of the Hip surgery, Hip Joint surgery, Hip Prosthesis
Abstract: Background: One goal of THA is to restore the anatomic hip center, which can be achieved in hips with developmental dysplasia by placing cups at the level of the native acetabulum. However, this might require adjuvant procedures such as femoral shortening osteotomy. Another option is to place the cup at the high hip center, potentially reducing surgical complexity. Currently, no clear consensus exists regarding which of these cup positions might offer better functional outcomes or long-term survival., Question/purpose: We performed a systematic review to determine whether (1) functional outcomes as measured by the Harris hip score, (2) revision incidence, and (3) complications that do not result in revision differ based on the position of the acetabular cup (high hip center versus anatomic hip center) in patients undergoing THA for developmental dysplasia of the hip (DDH)., Methods: We performed a systematic review using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, including studies comparing the functional outcomes, revision incidence, and complications of primary THA in dysplastic hips with acetabular cups placed at the high hip center versus those placed at the anatomic hip center, over any time frame. The review protocol was registered with PROSPERO (registration number CRD42020168183) before commencement. Of 238 records, eight comparative, retrospective nonrandomized studies of interventions were eligible for our systematic review, reporting on 207 hips with cups placed at the high hip center and 268 hips with cups at the anatomic hip center. Risk of bias within eligible studies was assessed using the Risk Of Bias In Non-randomized Studies of Interventions tool. Due to low comparability between studies, data could not be pooled, so these studies were assessed without summary effects., Results: Six studies compared Harris hip scores, two of which favored high hip center cup placement and three of which favored anatomic hip center cup placement, although none of the differences between cohorts met the minimum clinically important difference. Five studies reliably compared revision incidence, which ranged from 2% to 9% for high hip center at 7 to 15 years and 0% to 5.9% for anatomic hip center at 6 to 16 years. Five studies reported intra- and postoperative complications, with the high hip center being associated with higher incidence of dislocation and lower incidence of neurological complications. No clear difference was observed in intraoperative complications between the high hip center and anatomic hip center., Conclusion: No obvious differences could be observed in Harris hip score or revision incidence after THA for osteoarthritis secondary to DDH between cups placed at the anatomic hip center and those placed at the high hip center. Placement of the acetabular cup in the high hip center may lead to higher risk of dislocation but lower risk of neurologic complications, although no difference in intraoperative complications was observed. Surgeons should be able to achieve satisfactory functional scores and revision incidence using either technique, although they should be aware of how their choice influences hip biomechanics and the need for adjunct procedures and associated risks and operative time. These recommendations should be considered with respect to the several limitations in the studies reviewed, including the presence of serious confounding factors and selection biases, inconsistent definitions of the high hip center, variations in dysplasia severity, small sample sizes, and follow-up periods. These weaknesses should be addressed in well-designed future studies., Level of Evidence: Level III, therapeutic study., Competing Interests: All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request., (Copyright © 2021 by the Association of Bone and Joint Surgeons.)
Published: 2021
Full Text: View/download PDF

45. Identification of Chlamydia trachomatis genotypes in Mexican men with infertile women as sexual partners.

Author: López-Hurtado M, Escarcega-Tame MA, Escobedo-Guerra MR, de Haro-Cruz MJ, and Guerra-Infante FM
Abstract: Background: Chlamydia trachomatis is considered a public health problem due to the high prevalence in sexually active women and men. The distribution of genital Chlamydia genotypes among Mexican men is unknown., Objective: To assess the prevalence of Chlamydia genotypes in men with infertile women as sexual partners., Methods: A total of 659 urine samples were collected from men whose sexual partners were infertile women; the identifying Chlamydia infection was by means of a real-time nucleic acid amplification test (qPCR). OmpA gene PCR-RFLP and sequencing were used to confirm the genotypes of C. trachomatis. The association of genotypes with age, spermatic parameters and gynecological data of sexual partners was further analyzed., Results: Forty-nine urine samples were positive infection (7.4%). The Chlamydia infection was significantly associated with teratozoospermia, azoospermia, hypospermia, and oligozoospermia. Five genotypes (F 51%; 12.2% to D; 12.2% to E; 6.1% to L2 and 4.1% Ia) were correctly identified. None genotypes identified in this comparative study were positively associated with changes in some of the spermatic values because all of them typically produce some considerable damage to these cells., Conclusions: The F genotype was the most frequent genotype identified in infertile men from Mexico City and all genotypes play an important role in the seminal alteration of Mexican men whose female partners are infertile., (Copyright © 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Publicado por Elsevier España, S.L.U. All rights reserved.)
Published: 2021
Full Text: View/download PDF

46. Surgical Technique and Case Series of Total Hip Arthroplasty with the Hueter Anterior Approach for Crowe Type-IV Dysplasia.

Author: Viamont-Guerra MR, Saffarini M, and Laude F
Subjects: Acetabulum surgery, Adolescent, Adult, Aged, Female, Femur Neck surgery, Hip Dislocation diagnostic imaging, Humans, Male, Middle Aged, Osteotomy methods, Retrospective Studies, Surgical Wound surgery, Young Adult, Arthroplasty, Replacement, Hip methods, Hip Dislocation surgery
Abstract: Background: Total hip arthroplasty (THA) is being increasingly performed via the Hueter anterior approach (HAA), which has proven benefits with nondysplastic hips; however, little has been published on its outcomes with dysplastic hips, where it can provide better acetabular exposure. We describe our technique for THA via the HAA in hips with Crowe type-IV developmental dysplasia and report the mid-term outcomes of cases that were performed over 5 consecutive years., Methods: We retrospectively evaluated a continuous series of 8 hips (6 patients) with Crowe type-IV dysplasia; the patient ages ranged from 44 ± 20 years (range, 17 to 65 years) at the index THA. All of the patients received uncemented implants via the HAA on a traction table to restore the hip center of rotation to the true acetabulum. Femoral head autografts (FHAs) were used to increase acetabular coverage in 6 hips, and subtrochanteric shortening osteotomies (SSOs) were performed in 5 hips. Patients were assessed clinically and radiographically at a minimum follow-up of 2 years., Results: There were no revisions, deaths, dislocations, or infections. Two hips (25%) had intraoperative complications, and 1 hip (13%) had a postoperative complication that required reoperation without implant removal. All of the hips were assessed clinically and radiographically at 4 ± 1 years (range, 2 to 6 years). The modified Harris hip score (mHHS) improved from 33 ± 7 to 90 ± 7, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) improved from 53 ± 14 to 89 ± 6; the postoperative leg-length discrepancy was 3.2 mm (range, -10 to 20 mm). None of the hips had osteolysis or radiolucent lines of >2 mm., Conclusions: THA via the HAA on a traction table for hips with Crowe type-IV dysplasia yielded satisfactory mid-term outcomes. Both FHA and SSO can be adequately performed via the HAA to help restore the hip center of rotation to the true acetabulum., Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Published: 2020
Full Text: View/download PDF

47. Co-infection between genotypes of the human papillomavirus and Chlamydia trachomatis in Mexican women.

Author: Escarcega-Tame MA, López-Hurtado M, Escobedo-Guerra MR, Reyes-Maldonado E, Castro-Escarpulli G, and Guerra-Infante FM
Subjects: Adult, Cervix Uteri pathology, Chlamydia Infections diagnosis, Chlamydia trachomatis isolation & purification, Female, Genotype, Humans, Mexico, Middle Aged, Papillomaviridae isolation & purification, Papillomavirus Infections diagnosis, Polymerase Chain Reaction, Prevalence, Uterine Cervical Neoplasms epidemiology, Uterine Cervicitis epidemiology, Vaginal Smears, Young Adult, Uterine Cervical Dysplasia epidemiology, Chlamydia Infections epidemiology, Chlamydia trachomatis genetics, Coinfection epidemiology, Papillomaviridae genetics, Papillomavirus Infections epidemiology, Vagina microbiology, Vagina virology
Abstract: Not all human papillomavirus (HPV) infections develop into cervical cancer (CC), so it is proposed that other factors may influence this, such as co-infection with Chlamydia trachomatis (CT). To identify the prevalence of co-infection, we included 189 women with suspicion of HPV. Viral typing was performed by carrying out the Roche HP Linear Array test, while CT detection was performed with the COBAS® TaqMan® 48 kit from Roche. Of the 189 women only 184 had an infection with HPV, CT or both: 56.6% were positive for one or several HPV genotypes, and 67.7% for CT. Clinical data showed an association between HPV and CIN I (n = 22; RR = 2.43; 95% CI 1.72-3.43, p < 0.05). CT infection was only associated with cervicitis (n = 40; RR = 1.73; 95% CI 1.34-2.23, p < 0.05). The CT-HPV co-infection rate was 28%. Co-infection revealed an association with CIN I (n = 31, RR= 3.33; 95% CI 2.08-5.34 p < 0.05), CIN III (n = 7; RR = 2.57; 95% CI 1.53-4.31, p < 0.05); and a significant risk of 2.3 (95% CI 1.08-4.90) times higher to develop CC; nevertheless, this risk was not statistically significant. CT/HPV co-infection was associated with the development of a high-grade lesion (CIN III) as well as an important risk for developing CC.
Published: 2020
Full Text: View/download PDF

48. Reply to Letter to the Editor on "The Direct Anterior Approach for Total Hip Arthroplasty for Severe Dysplasia (Crowe III and IV) Provides Satisfactory Medium to Long-Term Outcomes".

Author: Viamont-Guerra MR, Chen AF, Stirling P, Nover L, Guimarães RP, Saffarini M, and Laude F
Subjects: Humans, Arthroplasty, Replacement, Hip adverse effects, Hip Dislocation, Congenital surgery, Hip Prosthesis
Published: 2020
Full Text: View/download PDF

49. Inequalities in the burden of female breast cancer in Brazil, 1990-2017.

Author: Guerra MR, Nogueira MC, Malta DC, Côrrea CSL, de Souza MFM, Curado MP, Felisbino-Mendes MS, Mooney M, Naghavi M, and Bustamante-Teixeira MT
Subjects: Brazil epidemiology, Breast Neoplasms mortality, Female, Global Burden of Disease, Global Health, Health Status Disparities, Humans, Incidence, Quality-Adjusted Life Years, Risk Factors, Breast Neoplasms epidemiology, Socioeconomic Factors
Abstract: Background: Breast cancer is the most frequently diagnosed cancer in women and the leading cause of cancer death among females worldwide. In recent decades, breast cancer death rates have been stable or decreasing in more developed regions; however, this has not been observed in less developed regions. This study aims to evaluate inequalities in the burden of female breast cancer in Brazil including an analysis of interregional and interstate patterns in incidence, mortality and disability-adjusted life years (DALYs) rates from 1990 to 2017, and mortality-to-incidence ratio (MIR), and their association with the Socio-demographic Index (SDI)., Methods: Using estimates from the global burden of disease (GBD) study, we applied a spatial exploratory analysis technique to obtain measurements of global and local spatial correlation. Percentage changes of breast cancer incidence, mortality, and DALYs rates between 1990 and 2017 were calculated, and maps were developed to show the spatial distribution of the variables. Spatial panel models were adjusted to investigate the association between rates and SDI in Brazilian states., Results: In Brazil, while breast cancer mortality rate have had modest reduction (-4.45%; 95% UI: -6.97; -1.76) between 1990 and 2017, the incidence rate increased substantially (+39.99%; 95% UI: 34.90; 45.39). Breast cancer incidence and mortality rates in 1990 and 2017 were higher in regions with higher SDI, i.e., the most developed ones. While SDI increased in all Brazilian states between 1990 and 2017, notably in less developed regions, MIR decreased, more notably in more developed regions. The SDI had a positive association with incidence rate and a negative association with MIR., Conclusion: Such findings suggest an improvement in breast cancer survival in the period, which may be related to a broader access to diagnostic methods and treatment. This study also revealed the inequality in breast cancer outcomes among Brazilian states and may guide public policy priorities for disease control in the country.
Published: 2020
Full Text: View/download PDF

50. The Global Burden of Disease Study Estimates of Brazil's Cervical Cancer Burden.

Author: Reis NVS, Andrade BB, Guerra MR, Teixeira MTB, Malta DC, and Passos VMA
Subjects: Adult, Brazil epidemiology, Female, Global Burden of Disease, Humans, Incidence, Life Expectancy, Middle Aged, Mortality, Premature, Quality-Adjusted Life Years, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms epidemiology
Abstract: Background: Cervical cancer represents an important preventable cause of morbidity and mortality in developing countries such as Brazil. Investigating temporal evolution of a disease burden in the different realities of the country is essential for improving public policies., Objective: To describe the national and subnational burden of cervical cancer, based on the estimates of the 2017 Global Burden of Disease study., Methods: Descriptive study of premature mortality (years of life lost [YLL]) and burden of disease (disability-adjusted life years [DALYs]) associated with cervical cancer among Brazilian women aged 25-64 years, between 2000 and 2017., Findings: During the study period, age-standardized incidence decreased from 23.53 (22.79-24.26) to 18.39 (17.63-19.17) per 100,000 women, while mortality rates decreased from 11.3 (11.05-11.56) to 7.74 (7.49-8.02) per 100,000 women. These rates were about two to three times greater than equivalent rates in a developed country, such as England: 11.98 (11.45-12.55) to 10.37 (9.85-10.9), and 3.75 (3.68-3.84) to 2.82 (2.75-2.9) per 100,000 women, respectively. Poorer regions of Brazil had greater rates of the disease; for instance, Amapá State in the Northern Region had rates twice as high as the national rates during the same period. Cervical cancer was the leading cause of premature cancer-related mortality (YLL = 100.69, 91.48-110.61 per 100,000 women) among young women (25-29 years) in Brazil and eight federation units of all country regions except the Southeast in 2017. There was a decrease in the burden of cervical cancer in Brazil from 339.59 (330.82-348.83) DALYs per 100,000 women in 2000 to 238.99 (230.45-247.99) DALYs per 100,000 women in 2017., Conclusion: Although there has been a reduction in the burden of cervical cancer in Brazil, the rates remain high, mainly among young women. The persistence of inequalities between regions of Brazil suggests the importance of socioeconomic determinants in the burden for this cancer., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2020 The Author(s).)
Published: 2020
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

109 results on '"Guerra, MR"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources