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1. The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones

Author

Norais, C, Servant, P, Bouthier-de-la-Tour, C, Coureux, PD, Ithurbide, S, Vannier, F, Guerin, PP, Dulberger, CL, Satyshur, KA, Keck, JL, Armengaud, J, Cox, MM, Sommer, S, Norais, C, Servant, P, Bouthier-de-la-Tour, C, Coureux, PD, Ithurbide, S, Vannier, F, Guerin, PP, Dulberger, CL, Satyshur, KA, Keck, JL, Armengaud, J, Cox, MM, and Sommer, S

Abstract

The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates. © 2013 Norais et al.

Published
2013

2. The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones.

Author

Norais C, Servant P, Bouthier-de-la-Tour C, Coureux PD, Ithurbide S, Vannier F, Guerin PP, Dulberger CL, Satyshur KA, Keck JL, Armengaud J, Cox MM, and Sommer S

Subjects
Amino Acid Sequence, Bacterial Proteins chemistry, Base Sequence, Deinococcus genetics, Deinococcus growth & development, Deinococcus radiation effects, Models, Molecular, Molecular Chaperones chemistry, Molecular Sequence Data, Mutation, Protein Binding, Protein Conformation, Radiation Tolerance genetics, Sequence Alignment, Bacterial Proteins metabolism, Bacterial Secretion Systems, Deinococcus metabolism, Molecular Chaperones metabolism
Abstract

The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates.

Published
2013
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