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15 results on '"Gueorguiev, Volodia"'

6. Abstract 4689: Inhibition of IL-6/Jak/Stat3 signaling: a novel and potent targeting therapy for lung cancer

Author

Gao, Sizhi P., primary, Mao, Ninghui, additional, Schori, Erez, additional, Liu, Shuhui, additional, Daly, Laura, additional, Barlas, Afsar, additional, Gueorguiev, Volodia D., additional, Zhao, Huiyong, additional, Qiu, Juan, additional, Hefter, Blake, additional, Regales, Lucia, additional, Chmielecki, Juliann, additional, Pao, William, additional, and Bromberg, Jacqueline F., additional

Published
2011
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13. Differing temporal roles of Ca2+ and cAMP in nicotine-elicited elevation of tyrosine hyroxylase mRNA

Author

Gueorguiev, Volodia D., Zeman, Richard J., Hiremagalur, Bhargava, Menezes, Ana, and Sabban, Esther L.

Subjects
Rats -- Physiological aspects, Adrenal medulla -- Physiological aspects, Cyclic adenylic acid -- Physiological aspects, Calcium channels -- Physiological aspects, Nicotine -- Physiological aspects, Tyrosine -- Research, Hydroxylases -- Research, Gene expression -- Research, Biological sciences
Abstract

The role of cAMP- and Ca2+-mediated pathways in the nicotine-elicited elevation of tyrosine hydroxylase (TH) gene expression in rat adrenal medulla cells was investigated. Results showed the second rise in [Ca2+]i that is longer but more moderate than the initial transient is necessary for the activation of TH gene expression. The induction of TH gene expression by nicotine was found to involve several temporal phases, with each having different Ca2+ and cAMP requirements.

Published
1999

14. Role of Ca2in induction of neurotransmitter-related gene expression by butyrate

Author

Zia, Muhammad T., Nankova, Bistra B., Krishnan, Kavitha, Gueorguiev, Volodia D., Frenz, Christopher M., Sabban, Esther L., and Gamma, Edmund F. La

Abstract

We examined the effect of butyrate on neurotransmitter-related gene expression and calcium homeostasis in PC12 cells. Pretreatment with Ca2chelators (EGTA or BAPTA-AM) attenuated the butyrate-triggered accumulation of TH and ppEnk mRNA indicating that Ca2plays a role in butyrate-induced regulation of neuronal genes. Butyrate alone did not alter intracellular Ca2levels as determined by Fura-PE3 fluorescence; however, pretreatment with butyrate (18–24 h) reduced the first Ca2peak and prevented the second sustained rise in Ca2ias induced by nicotine or ryanodine. In contrast, butyrate had no effect on Ca2transients when added shortly before or during nicotine or ryanodine stimulation. These results suggest that chronic butyrate exposure can modulate cell responses by affecting intracellular Ca2signaling.

Published
2004

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