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12. Clinical authorization of amyloid PET in France: Towards a more precise diagnosis of Alzheimer's disease

Author

Verger, A., primary, Horowitz, T., additional, Le Jeune, F., additional, Prunier-Aesh, C., additional, Querellou, S., additional, Habert, M.-O., additional, Guedj, E., additional, Bouvet, C., additional, Bund, C., additional, Darcourt, J., additional, De Leiris, N., additional, Flaus, A., additional, Kas, A., additional, Kotzki, P.-O., additional, Meyer, M., additional, Namer, I., additional, Payoux, P., additional, Santiago-Ribeiro, M.-J., additional, Semah, F., additional, and Verger, A., additional

Published
2023
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13. Innovative treatments for meningiomas

Author

Graillon, T., primary, Tabouret, E., additional, Salgues, B., additional, Horowitz, T., additional, Padovani, L., additional, Appay, R., additional, Farah, K., additional, Dufour, H., additional, Régis, J., additional, Guedj, E., additional, Barlier, A., additional, and Chinot, O., additional

Published
2023
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30. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Author

Jansen, W.J., Janssen, O., Tijms, B.M., Vos, S.J.B., Ossenkoppele, R., Visser, P.J., Group, A.B.S., Aarsland, D., Alcolea, D., Altomare, D., Arnim, C. von, Baiardi, S., Baldeiras, I., Barthel, H., Bateman, R.J., Berckel, B. Van, Binette, A.P., Blennow, K., Boada, M., Boecker, H., Bottlaender, M., Braber, A., Brooks, D.J., Buchem, M.A. van, Camus, V., Carill, J.M., Cerman, J., Chen, K., Chételat, G., Chipi, E., Cohen, A.D., Daniels, A., Delarue, M., Didic, M., Drzezga, A., Dubois, B., Eckerström, M., Ekblad, L.L., Engelborghs, S., Epelbaum, S., Fagan, A.M., Fan, Y., Fladby, T., Fleisher, A.S., Flier, W.M. van der, Förster, S., Fortea, J., Frederiksen, K.S., Freund-Levi, Y., Frings, L., Frisoni, G.B., Fröhlich, L., Gabryelewicz, T., Gertz, H.J., Gill, K.D., Gkatzima, O., Gómez-Tortosa, E., Grimmer, T., Guedj, E., Habeck, C.G., Hampel, H., Handels, R., Hansson, O., Hausner, L., Hellwig, S., Heneka, M.T., Herukka, S.K., Hildebrandt, H., Hodges, J., Hort, J., Huang, C.C., Iriondo, A.J., Itoh, Y., Ivanoiu, A., Jagust, W.J., Jessen, F., Johannsen, P., Johnson, K.A., Kandimalla, R., Kapaki, E.N., Kern, S., Kilander, L., Klimkowicz-Mrowiec, A., Klunk, W.E., Koglin, N., Kornhuber, J., Kramberger, M.G., Kuo, H.C., Laere, K. Van, Landau, S.M., Landeau, B., Lee, Dyantha I. van der, Leon, M., Leyton, C.E., Lin, K.J., Lleó, A., Löwenmark, M., Madsen, K., Maier, W., Marcusson, J., Olde Rikkert, M.G.M., Verbeek, M.M., Zboch, M., Zetterberg, H., Jansen, W.J., Janssen, O., Tijms, B.M., Vos, S.J.B., Ossenkoppele, R., Visser, P.J., Group, A.B.S., Aarsland, D., Alcolea, D., Altomare, D., Arnim, C. von, Baiardi, S., Baldeiras, I., Barthel, H., Bateman, R.J., Berckel, B. Van, Binette, A.P., Blennow, K., Boada, M., Boecker, H., Bottlaender, M., Braber, A., Brooks, D.J., Buchem, M.A. van, Camus, V., Carill, J.M., Cerman, J., Chen, K., Chételat, G., Chipi, E., Cohen, A.D., Daniels, A., Delarue, M., Didic, M., Drzezga, A., Dubois, B., Eckerström, M., Ekblad, L.L., Engelborghs, S., Epelbaum, S., Fagan, A.M., Fan, Y., Fladby, T., Fleisher, A.S., Flier, W.M. van der, Förster, S., Fortea, J., Frederiksen, K.S., Freund-Levi, Y., Frings, L., Frisoni, G.B., Fröhlich, L., Gabryelewicz, T., Gertz, H.J., Gill, K.D., Gkatzima, O., Gómez-Tortosa, E., Grimmer, T., Guedj, E., Habeck, C.G., Hampel, H., Handels, R., Hansson, O., Hausner, L., Hellwig, S., Heneka, M.T., Herukka, S.K., Hildebrandt, H., Hodges, J., Hort, J., Huang, C.C., Iriondo, A.J., Itoh, Y., Ivanoiu, A., Jagust, W.J., Jessen, F., Johannsen, P., Johnson, K.A., Kandimalla, R., Kapaki, E.N., Kern, S., Kilander, L., Klimkowicz-Mrowiec, A., Klunk, W.E., Koglin, N., Kornhuber, J., Kramberger, M.G., Kuo, H.C., Laere, K. Van, Landau, S.M., Landeau, B., Lee, Dyantha I. van der, Leon, M., Leyton, C.E., Lin, K.J., Lleó, A., Löwenmark, M., Madsen, K., Maier, W., Marcusson, J., Olde Rikkert, M.G.M., Verbeek, M.M., Zboch, M., and Zetterberg, H.

Abstract

Contains fulltext : 248802.pdf (Publisher’s version ) (Closed access)

Published
2022

36. Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Author

Chincarini, A, Peira, E, Morbelli, S, Pardini, M, Bauckneht, M, Arbizu, J, Castelo-Branco, M, Busing, K, de Mendonca, A, Didic, M, Dottorini, M, Engelborghs, S, Ferrarese, C, Frisoni, G, Garibotto, V, Guedj, E, Hausner, L, Hugon, J, Verhaeghe, J, Mecocci, P, Musarra, M, Queneau, M, Riverol, M, Santana, I, Guerra, U, Nobili, F, Chincarini A., Peira E., Morbelli S., Pardini M., Bauckneht M., Arbizu J., Castelo-Branco M., Busing K. A., de Mendonca A., Didic M., Dottorini M., Engelborghs S., Ferrarese C., Frisoni G. B., Garibotto V., Guedj E., Hausner L., Hugon J., Verhaeghe J., Mecocci P., Musarra M., Queneau M., Riverol M., Santana I., Guerra U. P., Nobili F., Chincarini, A, Peira, E, Morbelli, S, Pardini, M, Bauckneht, M, Arbizu, J, Castelo-Branco, M, Busing, K, de Mendonca, A, Didic, M, Dottorini, M, Engelborghs, S, Ferrarese, C, Frisoni, G, Garibotto, V, Guedj, E, Hausner, L, Hugon, J, Verhaeghe, J, Mecocci, P, Musarra, M, Queneau, M, Riverol, M, Santana, I, Guerra, U, Nobili, F, Chincarini A., Peira E., Morbelli S., Pardini M., Bauckneht M., Arbizu J., Castelo-Branco M., Busing K. A., de Mendonca A., Didic M., Dottorini M., Engelborghs S., Ferrarese C., Frisoni G. B., Garibotto V., Guedj E., Hausner L., Hugon J., Verhaeghe J., Mecocci P., Musarra M., Queneau M., Riverol M., Santana I., Guerra U. P., and Nobili F.

Abstract

Background: amyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation. Methods: We retrospectively enrolled three cohorts of cognitively impaired patients submitted to 18 F-florbetaben (53 subjects), 18 F-flutemetamol (62 subjects), 18 F-florbetapir (60 subjects)PET/CT respectively, in 6 European centres belonging to the EADC. The 175 scans were visually classified as positive/negative following approved criteria and further classified with a 5-step grading as negative, mild negative, borderline, mild positive, positive by 5 independent readers, blind to clinical data. Scan quality was also visually assessed and recorded. Semi-quantification was based on two quantifiers: the standardized uptake value (SUVr)and the ELBA method. We used a sigmoid model to relate the grading with the quantifiers. We measured the readers accord and inconsistencies in the visual assessment as well as the relationship between discrepancies on the grading and semi-quantifications. Conclusion: It is possible to construct a map between different tracers and different quantification methods without resorting to ad-hoc acquired cases. We used a 5-level visual scale which, together with a mathematical model, delivered cut-offs and transition regions on tracers that are (largely)independent from the population. All fluorinated tracers appeared to have the same contrast and discrimination ability with respect to the negative-to-positive grading. We validated the integration of both visual reading and different quantifiers in a more robust framework thus bri

Published
2019

41. Supplemental Material, sj-pdf-1-tor-10.1177_23978473211021072 - Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis

Author

Langston, T, Randazzo, J, Kogel, U, Hoeng, J, Martin, F, Titz, B, Guedj, E, Schneider, T, Prabhakar, B, Zhang, J, Oldham, M, and Lee, KM

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-tor-10.1177_23978473211021072 for Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis by T Langston, J Randazzo, U Kogel, J Hoeng, F Martin, B Titz, E Guedj, T Schneider, B Prabhakar, J Zhang, M Oldham and KM Lee in Toxicology Research and Application

Published
2021
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43. Guide de rédaction des protocoles d’examens d’imagerie de la neurotransmission pour l’exploration des mouvements anormaux

Author

Verger, A., primary, Darcourt, J., additional, Habert, M.-O., additional, Pallardy, A., additional, Santiago-Ribeiro, M.-J., additional, Le Jeune, F., additional, Payoux, P., additional, Guedj, E., additional, Bouvet, C., additional, Bund, C., additional, Isal, S., additional, Kas, A., additional, Kotzki, P.-O., additional, Namer, I., additional, Prunier, C., additional, Semah, F., additional, and Verger, A., additional

Published
2021
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47. Systems toxicology revealed reduced impact of ths 2.2 aerosol relative to 3R4F smoke on aortic smooth muscle cell aging and exacerbation effects in aged cells in vitro

Author

Poussin, C., primary, Van Der Toorn, M., additional, Scheuner, S., additional, Piault, R., additional, Kondylis, A., additional, Savioz, R., additional, Dulize, R., additional, Peric, D., additional, Guedj, E., additional, Maranzano, F., additional, Merg, C., additional, Morelli, M., additional, Egesipe, A.-L., additional, Johne, S., additional, Majeed, S., additional, Pak, C., additional, Schneider, T., additional, Schlage, W.K., additional, Ivanov, N.V., additional, Peitsch, M.C., additional, and Hoeng, J., additional

Published
2020
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48. Liste des Auteurs

Author

Bach, G., primary, Bard, H., additional, Berthelot, J.-M., additional, Biette, G., additional, Boche, O., additional, Bonnefoy, O., additional, Bonvarlet, J.-P., additional, Bouvard, M., additional, Brasseur, J.-L., additional, Brunet, B., additional, Brunet-Guedj, E., additional, Buy, J.-N., additional, Catonné, Y., additional, Cohen, M., additional, Coudreuse, J.-M., additional, Courroy, J.-B., additional, De Labareyre, H., additional, De Lecluse, J., additional, Demarais, Y., additional, Demondion, X., additional, Djian, P., additional, Fichez, O., additional, Folinais, D., additional, Godefroy, D., additional, Grangeon, E., additional, Judet, T., additional, Kouvalchouk, J.-F., additional, Lequesne, M., additional, Lippa, A., additional, Luciani, J.-F., additional, Meyer, A., additional, Morvan, G., additional, Moudden, N., additional, Paclet, J.-P., additional, Parier, J., additional, Piriou, P., additional, Poux, D., additional, Reboul, G., additional, Renoux, J., additional, Rochcongar, P., additional, Rodineau, J., additional, Roger, B., additional, Rolland, E., additional, Sariali, E., additional, Simon, A., additional, Tamalet, B., additional, Thiescé, A., additional, Vuillemin, V., additional, and Zeitoun-Eiss, D., additional

Published
2009
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