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The paper presents the results of study of the coagulation process of the whole blood with anticoagulant using the method of laser speckle correlation. The clotting time dependence curves of the correlation coefficient have been presented and discussed. Analyzing the changing trend of these curves is possible to assess the clotting time, which prove the capability of using the method of laser speckle correlation for determining the diseases of blood coagulation.

In this paper, we discuss an application of the method of laser-speckle correlation for studying the process of fibrin formation in blood plasma. A module for recording and processing speckle images based on a debugging kit for the Atxmega128A1 microcontroller has been developed. The results of testing the developed module as part of a laboratory setup based on a diode laser using standard reagents are presented. The developed device allows obtaining a curve characterizing the process of fibrin formation in blood plasma, with the use of which it is possible to determine the clotting time.

In this paper, we discuss an application of the method of the Digital Laser Speckle Image Correlation method for studying the aggregation function of platelets in whole blood with the maximum standardization of the pre-analytical and analytical stages of the study. The method with native blood allowed to identify the difference between platelet aggregation activity of volunteers of Siberian population. Materials and images are provided, methods are explained. Correlation analysis of the obtained results showed a high correlation of the proposed technique with the method of Low-Frequency Piezoelectric Tromboelastography.