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30 results on '"Guarino, M.P.L."'

3. T.10.8 THE EFFECTS OF HIGH AMYLOSE PRODUCTS ON SYMPTOMS AND GUT MICROBIOTA COMPOSITION IN IRRITABLE BOWEL SYNDROME WITH PREDOMINANT CONSTIPATION (IBS-C)

Author

Altomare, A., primary, Di Rosa, C., additional, Putignani, L., additional, Emerenziani, S., additional, Nicolo, R., additional, De Arcangelis, E., additional, Crucilla, S., additional, Terrigno, V., additional, Conti, C., additional, Citterio, N., additional, Marconi, E., additional, De Gara, L., additional, Cicala, M., additional, and Guarino, M.P.L., additional

Published
2023
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4. T.04.9 ROLE OF DIETARY HABITS ON SYMPTOM CONTROL AND GUT MICROBIOTA COMPOSITION IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH CONSTIPATION (IBS-C)

Author

Altomare, A., primary, Di Rosa, C., additional, Putignani, L., additional, Emerenziani, S., additional, Fabris, S., additional, Ristori, M.V., additional, Crucillà, S., additional, Calò, C., additional, Nicolò, R., additional, Ciccozzi, M., additional, Cicala, M., additional, and Guarino, M.P.L., additional

Published
2022
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6. Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus

Author

Emerenziani, S., Sifrim, D., Habib, F.I., Ribolsi, M., Guarino, M.P.L., Rizzi, M., Caviglia, R., Petitti, T., and Cicala, M.

Subjects
Gastroesophageal reflux -- Development and progression, Gastroesophageal reflux -- Research, Gastric acid -- Analysis, Hydrogen-ion concentration -- Measurement, Hydrogen-ion concentration -- Analysis, Health
Published
2008

7. Outcome of endoscopic sphincterotomy in post cholecystectomy patients with sphincter of Oddi dysfunction as predicted by manometry and quantitative choledochoscintigraphy. (Biliary Tract)

Author

Cicala, M., Habib, F.I., Vavassori, P., Pallotta, N., Schillaci, O., Costamagna, G., Guarino, M.P.L., Scopinaro, F., Fiocca, F., Torsoli, A., and Corazziari, E.

Subjects
Sphincter of Oddi -- Methods, Endoscopy -- Methods, Surgery -- Methods, Health, Methods
Abstract

Background: Sphincter of Oddi dysfunction is diagnosed at manometry and, after cholecystectomy, non-invasively at quantitative choledochoscintigraphy. Patients may benefit from endoscopic sphincterotomy. Aims: The aim of this study was to [...]

Published
2002

11. OC.04.6 FECAL AND MUCOSAL MICROBIOTA PROFILING IN IRRITABLE BOWEL SYNDROME AND INFLAMMATORY BOWEL DISEASE: A FOCUS ON AKKERMANSIA MUCINIPHILA

Author

Lo Presti, A., primary, Zorzi, F., additional, Del Chierico, F., additional, Altomare, A., additional, Cocca, S., additional, Avola, A., additional, Cella, E., additional, Calabrese, E., additional, Biancone, L., additional, Monteleone, G., additional, Cicala, M., additional, Angeletti, S., additional, Ciccozzi, M., additional, Putignani, L., additional, and Guarino, M.P.L., additional

Published
2019
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13. PLATELET ACTIVATING FACTOR AND DISTINCT CHEMOKINES ARE ELEVATED IN MUCOSAL BIOPSIES OF EROSIVE COMPARED TO NON-EROSIVE REFLUX DISEASE PATIENTS AND CONTROLS

Author

Altomare, A., Ma, J., Guarino, M.P.L., Cheng, L., Rieder, F., Ribolsi, M., Fiocchi, C., Biancani, P., Harnett, K., and Cicala, M.

Subjects
Adult, Male, Biopsy, Enzyme-Linked Immunosorbent Assay, Middle Aged, Real-Time Polymerase Chain Reaction, Article, Gastroesophageal Reflux, Humans, Female, Chemokines, Platelet Activating Factor, Esophagitis, Peptic, Aged
Abstract

A distinction between symptomatic non-erosive reflux disease (NERD) and erosive esophagitis (EE) patients is supported by the presence of inflammatory response in the mucosa of EE patients, leading to a damage of mucosal integrity. To explore the underlying mechanism of this difference, we assessed inflammatory mediators in mucosal biopsies from EE and NERD patients and compared them with controls.Nineteen NERD patients, 15 EE patients, and 16 healthy subjects underwent endoscopy after a 3-week washout from PPI or H(2) antagonists. Biopsies obtained from the distal esophagus were examined by quantitative real-time polymerase chain reaction (qPCR) and multiplex enzyme-linked immunosorbent assay for selected chemokines and lyso-PAF acetyltransferase (LysoPAF-AT), the enzyme responsible for production of platelet-activating factor (PAF).Expression of LysoPAF-AT and multiple chemokines was significantly increased in mucosal biopsies derived from EE patients, when compared with NERD patients and healthy controls. Upregulated chemokines included interleukin 8, eotaxin-1, -2, and -3, macrophage inflammatory protein-1α (MIP-1α), and monocyte chemoattractant protein-1 (MCP-1). LysoPAF-AT and the chemokine profile in NERD patients were comparable with healthy controls.Levels of selected cytokines and Lyso-PAF AT were significantly higher in the esophageal mucosa of EE patients compared with NERD and control patients. This difference may explain the distinct inflammatory response occurring in EE patients' mucosa. In contrast, as no significant differences existed between the levels of all mediators in NERD and control subjects, an inflammatory response does not appear to play a major role in the pathogenesis of the abnormalities found in NERD patients.

Published
2012

14. Decreased number of activated macrophages in gallbladder muscle layer of cholesterol gallstone patients following ursodeoxycholic acid

Author

Guarino, M.P.L., Carotti, S., Morini, S., Perrone, G., Behar, J., Altomare, A., Alloni, R., Caviglia, R., Emerenziani, S., Rabitti, C., and Cicala, M.

Subjects
Ursodiol -- Research, Ursodiol -- Physiological aspects, Macrophages -- Research, Macrophages -- Physiological aspects, Gallbladder -- Research, Gallbladder -- Physiological aspects, Health
Published
2008

15. Exposure of Toll-like receptors 4 to bacterial lipopolysaccharide (LPS) impairs human colonic smooth muscle cell function

Author

Scirocco A., Matarrese P., Petitta C., Cicenia A., Ascione B., Mannironi C., Ammostato F., Cardi M., Fanello G., Guarino M.P.L., and Malori W. And Severi C.

Abstract

Endotoxemia by bacterial lipopolysaccharide (LPS) has been reported to affect gut motility specifically depending on Toll-like receptor 4 activation (TLR4). However, the direct impact of LPS ligation to TLR4 on human smooth muscle cells (HSMC) activity still remains to be elucidated. The present study shows that TLR4, its associated molecule MD2, and TLR2 are constitutively expressed on cultured HSMC and that, once activated, they impair HSMC function. The stimulation of TLR4 by LPS induced a time- and dose-dependent contractile dysfunction, which was associated with a decrease of TLR2 messenger, a rearrangement of microfilament cytoskeleton and an oxidative imbalance, i.e., the formation of reactive oxygen species (ROS) together with the depletion of GSH content. An alteration of mitochondria, namely a hyperpolarization of their membrane potential, was also detected. Most of these effects were partially prevented by the NADPH oxidase inhibitor apocynin or the NFkappaB inhibitor MG132. Finally, a 24 h washout in LPS-free medium almost completely restored morphofunctional and biochemical HSMC resting parameters, even if GSH levels remained significantly lower and no recovery was observed in TLR2 expression. Thus, the exposure to bacterial endotoxin directly and persistently impaired gastrointestinal smooth muscle activity indicating that HSMC actively participate to dysmotility during infective burst. The knowledge of these interactions might provide novel information on the pathogenesis of infection-associated gut dysmotility and further clues for the development of new therapeutic strategies.

Published
2010

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