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Purpose: The aim of this study was to evaluate the effect of the topical application of growth hormone on the osseointegration of dental implants in beagle dogs 14 days after placement. Materials and Methods: Maxillary and mandibular premolars and molars were extracted from 12 beagle dogs. Two months later, each mandible received cylindric screw-type implants of 3.25 mm in diameter and 10 mm in length. The implants were randomly assigned to the mesial and distal sites on each side of the mandible. Prior to implantation, lyophilized powdered growth hormone was applied to one osteotomy on each side of the mandible. No growth hormone was applied at the control sites. Eight histologic sections per implant were obtained for histomorphometric analysis. Results: After a 2-week treatment period, the growth hormone—treated sites showed significant (P < .0001) increases in the perimeter of bone that was in direct contact with the treated implants (40.19% ± 2.51%), total peri-implant area (P < .001) (69.57% ± 3.53%), and new bone formation (P < .0001) (35.18% ± 0.31%), in comparison to control implants (25.05% ± 2.43%, 53.40% ± 4.58%, and 28.65% ± 1.92%, respectively). There was no significant increase in interthread bone in growth hormone-treated implants (27.92% ± 3.31%) in comparison to control implants (25.08% ± 3.47%) (P > .05). Conclusion: Topical application of growth hormone may act as a bone stimulant in the placement of endosseous dental implants. [ABSTRACT FROM AUTHOR]

Local dynamics play a key role in individual and collective empowerment for digital literacy and citizenship. This paper presents the results and reflections from a broader investigation into the public Internet access places in Portugal in the inland municipalities of the country's coast, undertaken by ObLID Network. Specifically, we intend to reflect on the actual mission of these places and reveal the actual profile, activities and training needs of their monitors and coordinators. In the first stage of the empirical study, several documents available on the Internet Spaces Network are analyzed. In the second stage, a questionnaire was applied to monitors and coordinators of the Internet access places, in seventeen Portuguese municipalities. The research results warn of the need to redefine and clarify the social and educational value of Internet spaces, indicating that the dominant activities of monitors in the Internet access places do not induce the foster of literacy and digital inclusion of the most vulnerable groups. In this context, actions are proposed that can contribute to improving the mission of Internet places, as well as the training quality of their monitors and coordinators. Internet Access Spaces, made available by municipalities, should be used to promote digital literacy programs, for individuals and groups. [ABSTRACT FROM AUTHOR]

Few studies have assessed the relationships between xerostomia and the use of inhaled corticosteroids ( ICS). The main objective of this study was to investigate the prevalence of xerostomia in a respiratory outpatient clinic and its relationship with bronchial asthma and ICS use. A cross-sectional observational study of patients recruited in an outpatient setting divided them according to previous diagnoses of bronchial asthma. Data about pulmonary function, concomitant medication, medical comorbidities, Xerostomia Inventory test ( XI test), and the degree of asthma control by ACT (asthma control test) were collected for each patient. A linear regression model was applied, using the XI score as dependent variable and the ACT score as independent variable. The 57 patients were divided into asthmatics (40 patients, 70.2%) and control group without asthma (17, 29.8%). The prevalence of xerostomia was 87.7% (50 patients), with no differences between the study groups or current dose of ICS. In the asthmatic group, patients with uncontrolled asthma had worse XI scores than those with partially or totally controlled asthma (30.43 ± 8.71 vs. 24.92 ± 8.08; P < 0.05). In a logistic regression model, the XI test was significantly associated to ACT scores with a moderately strong correlation ( r = 0.55; P = 0.005) after adjusting for the current daily dose of ICS. Xerostomia is a common symptom in the ambulatory setting. There is a moderate relationship between the degree of asthma control and the severity of xerostomia. [ABSTRACT FROM AUTHOR]

In relation to the article of the Journal of Clinical and Experimental Dentistry "Calvo-Guirado JL, Aguilar-Salvatierra A, Guardia J, Delgado-Ruiz R, Ramírez-Fernández MP, Pérez-Sánchez C, Gómez-Moreno G. Evaluation of periimplant bone neoformation using different scanning electron microscope methods for measuring BIC. A dog study. J Clin Exp Dent. 2012 Feb 1;4(1):e8-e13", the authors have used three figures that are the same as those published in three different publications (J Pineal Res 2010; COIR 2010; COIR 2012). The copyright of the mentioned publications was consequently not respected. Retraction of the article is therefore decided.

Objectives: Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs., Study Design: This research has been carried out through a randomized double-blind clinical trial. 45 patients suffering from hypertensive drugs-induced xerostomia were divided into 2 groups: the first group (25 patients) received a topical sialogogue on spray (malic acid, 1%) whereas the second group (20 patients) received a placebo. Both of them were administered on demand for 2 weeks. Dry Mouth Questionnaire (DMQ) was used in order to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. All the statistical analyses were performed by using SPSS software v17.0. Different DMQ scores at the earliest and final stage of the trial were analysed by using Mann-Whitney U test, whereas Student's T-test was used to analyse salivary flows. Critical p-value was established at p<0.05., Results: DMQ scores increased significantly (clinical recovery) from 1.21 to 3.36 points (p<0.05) after malic acid (1%) application whereas DMQ scores increased from 1.18 to 1.34 points (p>0.05) after placebo application. After two weeks of treatment with malic acid, unstimulated salivary flow increased from 0.17 to 0.242 mL/min whereas the stimulated one increased from 0.66 to 0.92 mL/min (p<0.05). After placebo application unstimulated flow ranged from 0.152 to 0.146 mL/min and stimulated flow increased from 0.67 to 0.70 mL/min (p>0.05)., Conclusions: Malic acid 1% spray improved antihypertensive-induced xerostomia and stimulated the production of saliva.