233 results on '"Guardia, C"'
Search Results
2. Assessing pollen extreme events over a Mediterranean site: Role of local surface meteorology
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Cariñanos, P., Guerrero-Rascado, J.L., Valle, A.M., Cazorla, A., Titos, G., Foyo-Moreno, I., Alados-Arboledas, L., and Díaz de la Guardia, C.
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- 2022
- Full Text
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3. Methodology for monitoring Cement Based Materials at Early Age combining NDT techniques
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Barluenga, G., Puentes, J., Palomar, I., and Guardia, C.
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- 2018
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4. Lectotypification of Names of Linnaean Species of Scorzonera and Geropogon (Compositae, Lactuceae)
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de la Guardia, C. Díaz and Blanca, G.
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- 1997
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5. Shoulder Arthrodesis
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Jouve, Jean-Luc, Bollini, Gerard, Legre, R., Guardia, C., Choufani, E., Demakakos, J., Blondel, B., and Bentley, George, editor
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- 2014
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6. A new method for determining the sources of airborne particles
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Oteros, J., García-Mozo, H., Alcázar, P., Belmonte, J., Bermejo, D., Boi, M., Cariñanos, P., Díaz de la Guardia, C., Fernández-González, D., González-Minero, F., Gutiérrez-Bustillo, A.M., Moreno-Grau, S., Pérez-Badía, R., Rodríguez-Rajo, F.J., Ruíz-Valenzuela, L., Suárez-Pérez, J., Trigo, M.M., Domínguez-Vilches, E., and Galán, C.
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- 2015
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7. Intérêt de la toxine botulinique de type A dans le traitement des syndromes de Raynaud sévères secondaires à la sclérodermie systémique
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Serri, J., Legré, R., Veit, V., Guardia, C., and Gay, A.-M.
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- 2013
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8. Pollen calendars: a guide to common airborne pollen in Andalusia
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Martínez-Bracero, M., Alcázar, P., Díaz de la Guardia, C., González-Minero, F. J., Ruiz, L., Trigo Pérez, M. M., and Galán, C.
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- 2015
- Full Text
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9. mTOR inhibition and trastuzumab-emtansine (T-DM1) in HER2-positive breast cancer
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Casadevall D, Hernandez-Prat A, Garc A-Alonso S, Arpi-Llucia O, Menendez S, Qin M, Guardia C, Morancho B, Sanchez-Mart N F, Zazo S, Gavilan E, Sabbaghi M, Eroles P, Cejalvo J, Lluch A, Rojo F, Pandiella A, Rovira A, and Albanell J
- Abstract
In patients with trastuzumab-resistant HER2-positive breast cancer, the combination of everolimus (mTORC1 inhibitor) with trastuzumab failed to show a clinically significant benefit. However, the combination of mTOR inhibition and the antibody-drug conjugate (ADC) trastuzumab-emtansine (T-DM1) remains unexplored. We tested T-DM1 plus everolimus in a broad panel of HER2-positive breast cancer cell lines. The combination was superior to T-DM1 alone in four cell lines (HCC1954, SKBR3, EFM192A, and MDA-MB-36) and in two cultures from primary tumor cells derived from HER2-positive patient-derived xenografts (PDX), but not in BT474 cells. In the trastuzumab-resistant HCC1954 cell line, we characterized the effects of the combination using TAK-228 (mTORC1 and 2 inhibitor) and knockdown of the different mTOR complex components. T-DM1 did not affect mTOR downstream signaling nor induct autophagy. Importantly, mTOR inhibition increased intracellular T-DM1 levels, leading to increased lysosomal accumulation of the compound. The increased efficacy of mTOR inhibition plus T-DM1 was abrogated by lysosome inhibitors (chloroquine and bafilomycin A1). Our experiments suggest that BT474 are less sensitive to T-DM1 due to lack of optimal lysosomal processing and intrinsic resistance to the DM1 moiety. Finally, we performed several in vivo experiments that corroborated the superior activity of T-DM1 and everolimus in HCC1954 and PDX-derived mouse models. In summary, everolimus in combination with T-DM1 showed strong antitumor effects in HER2-positive breast cancer, both in vitro and in vivo. This effect might be related, at least partially, to mTOR-dependent lysosomal processing of T-DM1, a finding that might apply to other ADCs that require lysosomal processing. Implications: Inhibition of mTOR increases the anti-tumor activity of T-DM1, supporting that the combination of mTOR inhibitors and antibody-drug conjugates warrants clinical evaluation in patients with HER2-positive breast cancer.
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- 2022
10. Predicting the start and peak dates of the Poaceae pollen season in Spain using process-based models
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García-Mozo, H., Galán, C., Belmonte, J., Bermejo, D., Candau, P., Díaz de la Guardia, C., Elvira, B., Gutiérrez, M., Jato, V., Silva, I., Trigo, M.M., Valencia, R., and Chuine, I.
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- 2009
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11. The Autophagy, Inflammation and Metabolism Center international eSymposium - An early-career investigators' seminar series during the COVID-19 pandemic
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Nieto-Torres, J. L., Durgan, J., Franco-Romero, A., Grumati, P., Guardia, C. M., Leidal, A. M., Mandell, M. A., Towers, C. G., and Wang, F.
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- 2021
12. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard M, Abudu Y, Acevedo-Arozena A, Adamopoulos I, Adeli K, Adolph T, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal B, Agnello M, Agostinis P, Agrewala J, Agrotis A, Aguilar P, Ahmad S, Ahmed Z, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar H, Al-Abd A, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali M, Alberti S, Alcocer-Gomez E, Alessandri C, Ali M, Al-Bari M, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso G, Altan-Bonnet N, Altieri D, Alves S, da Costa C, Alzaharna M, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer A, Ammanathan V, An Z, Andersen S, Andrabi S, Andrade-Silva M, Andres A, Angelini S, Ann D, Anozie U, Ansari M, Antas P, Antebi A, Anton Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araujo W, Araya J, Arden C, Arevalo M, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa A, Armstrong-James D, Arnaune-Pelloquin L, Aroca A, Arroyo D, Arsov I, Artero R, Asaro D, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov A, Au A, Auberger P, Auner H, Aurelian L, Autelli R, Avagliano L, Avalos Y, Aveic S, Aveleira C, AvinWittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer J, Backues S, Bae D, Bae O, Bae S, Baehrecke E, Baek A, Baek S, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari C, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Bao Y, Baptista M, Baracca A, Barbati C, Bargiela A, Barila D, Barlow P, Barmada S, Barreiro E, Barreto G, Bartek J, Bartel B, Bartolome A, Barve G, Basagoudanavar S, Bassham D, Jr R, Basu A, Batoko H, Batten I, Baulieu E, Baumgarner B, Bayry J, Beale R, Beau I, Beaumatin F, Bechara L, Beck G, Beers M, Begun J, Behrends C, Behrens G, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touze N, Bellarosa C, Belleudi F, Perez M, Bello-Morales R, Beltran J, Beltran S, Benbrook D, Bendorius M, Benitez B, Benito-Cuesta I, Bensalem J, Berchtold M, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli C, Besteiro S, Betin V, Beyaert R, Bezbradica J, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan M, Bhutia S, Bi L, Bi X, Biden T, Bijian K, Billes V, Binart N, Bincoletto C, Birgisdottir A, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum J, Boada-Romero E, Boban M, BoeszeBattaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam S, Bonfili L, Bonifacino J, Boone B, Bootman M, Bordi M, Borner C, Bornhauser B, Borthakur G, Bosch J, Bose S, Botana L, Botas J, Boulanger C, Boulton M, Bourdenx M, Bourgeois B, Bourke N, Bousquet G, Boya P, Bozhkov P, Bozi L, Bozkurt T, Brackney D, Brandts C, Braun R, Braus G, Bravo-Sagua R, Bravo-San Pedro J, Brest P, Bringer M, Briones-Herrera A, Broaddus V, Brodersen P, Alvarez E, Brodsky J, Brody S, Bronson P, Bronstein J, Brown C, Brown R, Brum P, Brumell J, Brunetti-Pierri N, Bruno D, Bryson-Richardson R, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina L, Buraschi S, Buch S, Buchan J, Buckingham E, Budak H, Budini M, Bultynck G, Burada F, Burgoyne J, Buron M, Bustos V, Buttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairo M, Calbet J, Caldwell G, Caldwell K, Call J, Calvani R, Calvo A, Barrera M, Camara N, Camonis J, Camougrand N, Campanella M, Campbell E, Campbell-Valois F, Campello S, Campesi I, Campos J, Camuzard O, Cancino J, de Almeida D, Canesi L, Caniggia I, Canonico B, Canti C, Cao B, Caraglia M, Carames B, Carchman E, Cardenal-Munoz E, Cardenas C, Cardenas L, Cardoso S, Carew J, Carle G, Carleton G, Carloni S, Carmona-Gutierrez D, Carneiro L, Carnevali O, Carosi J, Carra S, Carrier A, Carrier L, Carroll B, Carter A, Carvalho A, Casanova M, Casas C, Casas J, Cassioli C, Castillo E, Castillo K, Castillo-Lluva S, Castoldi F, Castori M, Castro A, Castro-Caldas M, Castro-Hernandez J, Castro-Obregon S, Catz S, Cavadas C, Cavaliere F, Cavallini G, Cavinato M, Cayuela M, Rica P, Cecarini V, Cecconi F, Cechowska-Pasko M, Cenci S, Ceperuelo-Mallafre V, Cerqueira J, Cerutti J, Cervia D, Cetintas V, Cetrullo S, Chae H, Chagin A, Chai C, Chakrabarti G, Chakrabarti O, Chakraborty T, Chami M, Chamilos G, Chan D, Chan E, Chan H, Chan M, Chan Y, Chandra P, Chang C, Chang H, Chang K, Chao J, Chapman T, Charlet-Berguerand N, Chatterjee S, Chaube S, Chaudhary A, Chauhan S, Chaum E, Checler F, Cheetham M, Chen C, Chen G, Chen J, Chen L, Chen M, Chen N, Chen Q, Chen R, Chen S, Chen W, Chen X, Chen Y, Chen Z, Cheng H, Cheng J, Cheng S, Cheng W, Cheng X, Cheng Y, Cheng Z, Cheong H, Cheong J, Chernyak B, Cherry S, Cheung C, Cheung K, Chevet E, Chi R, Chiang A, Chiaradonna F, Chiarelli R, Chiariello M, Chica N, Chiocca S, Chiong M, Chiou S, Chiramel A, Chiurchiu V, Cho D, Choe S, Choi A, Choi M, Choudhury K, Chow N, Chu C, Chua J, Chung H, Chung K, Chung S, Chung Y, Cianfanelli V, Ciechomska I, Cifuentes M, Cinque L, Cirak S, Cirone M, Clague M, Clarke R, Clementi E, Coccia E, Codogno P, Cohen E, Cohen M, Colasanti T, Colasuonno F, Colbert R, Colell A, Coll N, Collins M, Colombo M, Colon-Ramos D, Combaret L, Comincini S, Cominetti M, Consiglio A, Conte A, Conti F, Contu V, Cookson M, Coombs K, Coppens I, Corasaniti M, Corkery D, Cordes N, Cortese K, Costa M, Costantino S, Costelli P, Coto-Montes A, Crack P, Crespo J, Criollo A, Crippa V, Cristofani R, Csizmadia T, Cuadrado A, Cui B, Cui J, Cui Y, Culetto E, Cumino A, Cybulsky A, Czaja M, Czuczwar S, D'Adamo S, D'Amelio M, D'Arcangelo D, D'Lugos A, D'Orazi G, da Silva J, Dafsari H, Dagda R, Dagdas Y, Daglia M, Dai X, Dai Y, Dal Col J, Dalhaimer P, Dalla Valle L, Dallenga T, Dalmasso G, Damme M, Dando I, Dantuma N, Darling A, Das H, Dasarathy S, Dasari S, Dash S, Daumke O, Dauphinee A, Davies J, Davila V, Davis R, Davis T, Naidu S, De Amicis F, De Bosscher K, De Felice F, De Franceschi L, De Leonibus C, Barbosa M, De Meyer G, De Milito A, De Nunzio C, De Palma C, De Santi M, De Virgilio C, De Zio D, Debnath J, DeBosch B, Decuypere J, Deehan M, Deflorian G, DeGregori J, Dehay B, Del Rio G, Delaney J, Delbridge L, Delorme-Axford E, Delpino M, Demarchi F, Dembitz V, Demers N, Deng H, Deng Z, Dengjel J, Dent P, Denton D, DePamphilis M, Der C, Deretic V, Descoteaux A, Devis L, Devkota S, Devuyst O, Dewson G, Dharmasivam M, Dhiman R, di Bernardo D, Di Cristina M, Di Domenico F, Di Fazio P, Di Fonzo A, Di Guardo G, Di Guglielmo G, Di Leo L, Di Malta C, Di Nardo A, Di Rienzo M, Di Sano F, Diallinas G, Diao J, Diaz-Araya G, Diaz-Laviada I, Dickinson J, Diederich M, Dieude M, Dikic I, Ding S, Ding W, Dini L, Dinic M, Dinkova-Kostova A, Dionne M, Distler J, Diwan A, Dixon I, Djavaheri-Mergny M, Dobrinski I, Dobrovinskaya O, Dobrowolski R, Dobson R, Emre S, Donadelli M, Dong B, Dong X, Dong Z, Ii G, Dotsch V, Dou H, Dou J, Dowaidar M, Dridi S, Drucker L, Du A, Du C, Du G, Du H, Du L, du Toit A, Duan S, Duan X, Duarte S, Dubrovska A, Dunlop E, Dupont N, Duran R, Dwarakanath B, Dyshlovoy S, Ebrahimi-Fakhari D, Eckhart L, Edelstein C, Efferth T, Eftekharpour E, Eichinger L, Eid N, Eisenberg T, Eissa N, Eissa S, Ejarque M, El Andaloussi A, El-Hage N, El-Naggar S, Eleuteri A, El-Shafey E, Elgendy M, Eliopoulos A, Elizalde M, Elks P, Elsasser H, Elsherbiny E, Emerling B, Emre N, Eng C, Engedal N, Engelbrecht A, Engelsen A, Enserink J, Escalante R, Esclatine A, Escobar-Henriques M, Eskelinen E, Espert L, Eusebio M, Fabrias G, Fabrizi C, Facchiano A, Facchiano F, Fadeel B, Fader C, Faesen A, Fairlie W, Falco A, Falkenburger B, Fan D, Fan J, Fan Y, Fang E, Fang Y, Fanto M, Farfel-Becker T, Faure M, Fazeli G, Fedele A, Feldman A, Feng D, Feng J, Feng L, Feng Y, Feng W, Araujo T, Ferguson T, Fernandez-Checa J, FernandezVeledo S, Fernie A, Ferrante A, Ferraresi A, Ferrari M, Ferreira J, Ferro-Novick S, Figueras A, Filadi R, Filigheddu N, FilippiChiela E, Filomeni G, Fimia G, Fineschi V, Finetti F, Finkbeiner S, Fisher E, Fisher P, Flamigni F, Fliesler S, Flo T, Florance I, Florey O, Florio T, Fodor E, Follo C, Fon E, Forlino A, Fornai F, Fortini P, Fracassi A, Fraldi A, Franco B, Franco R, Franconi F, Frankel L, Friedman S, Frohlich L, Fruhbeck G, Fuentes J, Fujiki Y, Fujita N, Fujiwara Y, Fukuda M, Fulda S, Furic L, Furuya N, Fusco C, Gack M, Gaffke L, Galadari S, Galasso A, Galindo M, Kankanamalage S, Galluzzi L, Galy V, Gammoh N, Gan B, Ganley I, Gao F, Gao H, Gao M, Gao P, Gao S, Gao W, Gao X, Garcera A, Garcia M, Garcia V, Garcia-Del Portillo F, Garcia-Escudero V, GarciaGarcia A, Garcia-Macia M, Garcia-Moreno D, Garcia-Ruiz C, Garcia-Sanz P, Garg A, Gargini R, Garofalo T, Garry R, Gassen N, Gatica D, Ge L, Ge W, Geiss-Friedlander R, Gelfi C, Genschik P, Gentle I, Gerbino V, Gerhardt C, Germain K, Germain M, Gewirtz D, Afshar E, Ghavami S, Ghigo A, Ghosh M, Giamas G, Giampietri C, Giatromanolaki A, Gibson G, Gibson S, Ginet V, Giniger E, Giorgi C, Girao H, Girardin S, Giridharan M, Giuliano S, Giulivi C, Giuriato S, Giustiniani J, Gluschko A, Goder V, Goginashvili A, Golab J, Goldstone D, Golebiewska A, Gomes L, Gomez R, Gomez-Sanchez R, Gomez-Puerto M, Gomez-Sintes R, Gong Q, Goni F, Gonzalez-Gallego J, Gonzalez-Hernandez T, Gonzalez-Polo R, Gonzalez-Reyes J, Gonzalez-Rodriguez P, Goping I, Gorbatyuk M, Gorbunov N, Gorojod R, Gorski S, Goruppi S, Gotor C, Gottlieb R, Gozes I, Gozuacik D, Graef M, Graler M, Granatiero V, Grasso D, Gray J, Green D, Greenhough A, Gregory S, Griffin E, Grinstaff M, Gros F, Grose C, Gross A, Gruber F, Grumati P, Grune T, Gu X, Guan J, Guardia C, Guda K, Guerra F, Guerri C, Guha P, Guillen C, Gujar S, Gukovskaya A, Gukovsky I, Gunst J, Gunther A, Guntur A, Guo C, Guo H, Guo L, Guo M, Gupta P, Fernandez A, Gupta S, Gupta V, Gustafsson A, Gutterman D, Ranjitha H, Haapasalo A, Haber J, Hadano S, Hafren A, Haidar M, Hall B, Hallden G, Hamacher-Brady A, Hamann A, Hamasaki M, Han W, Hansen M, Hanson P, Hao Z, Harada M, Harhaji-Trajkovic L, Hariharan N, Haroon N, Harris J, Hasegawa T, Nagoor N, Haspel J, Haucke V, Hawkins W, Hay B, Haynes C, Hayrabedyan S, Hays T, He C, He Q, He R, He Y, Heakal Y, Heberle A, Hejtmancik J, Helgason G, Henkel V, Herb M, Hergovich A, Herman-Antosiewicz A, Hernandez A, Hernandez C, Hernandez-Diaz S, Hernandez-Gea V, Herpin A, Herreros J, Hervas J, Hesselson D, Hetz C, Heussler V, Higuchi Y, Hilfiker S, Hill J, Hlavacek W, Ho E, Ho I, Ho P, Ho S, Ho W, Hobbs G, Hochstrasser M, Hoet P, Hofius D, Hofman P, Hohn A, Holmberg C, Hombrebueno J, Hong C, Hong Y, Hooper L, Hoppe T, Horos R, Hoshida Y, Hsin I, Hsu H, Hu B, Hu D, Hu L, Hu M, Hu R, Hu W, Hu Y, Hu Z, Hua F, Hua J, Hua Y, Huan C, Huang C, Huang H, Huang K, Huang M, Huang R, Huang S, Huang T, Huang X, Huang Y, Huber T, Hubert V, Hubner C, Hughes S, Hughes W, Humbert M, Hummer G, Hurley J, Hussain S, Hussey P, Hutabarat M, Hwang H, Hwang S, Ieni A, Ikeda F, Imagawa Y, Imai Y, Imbriano C, Imoto M, Inman D, Inoki K, Iovanna J, Iozzo R, Ippolito G, Irazoqui J, Iribarren P, Ishaq M, Ishikawa M, Ishimwe N, Isidoro C, Ismail N, Issazadeh-Navikas S, Itakura E, Ito D, Ivankovic D, Ivanova S, Iyer A, Izquierdo J, Izumi M, Jaattela M, Jabir M, Jackson W, Jacobo-Herrera N, Jacomin A, Jacquin E, Jadiya P, Jaeschke H, Jagannath C, Jakobi A, Jakobsson J, Janji B, JansenDurr P, Jansson P, Jantsch J, Jassey A, Jean S, JeltschDavid H, Jendelova P, Jenny A, Jensen T, Jessen N, Jewell J, Ji J, Jia L, Jia R, Jiang L, Jiang Q, Jiang R, Jiang T, Jiang X, Jiang Y, Jimenez-Sanchez M, Jin E, Jin F, Jin H, Jin L, Jin M, Jin S, Jo E, Joffre C, Johansen T, Johnson G, Johnston S, Jokitalo E, Jolly M, Joosten L, Jordan J, Joseph B, Ju D, Ju J, Juarez E, Judith D, Juhasz G, Jun Y, Jung C, Jung S, Jung Y, Jungbluth H, Jungverdorben J, Just S, Kaarniranta K, Kaasik A, Kabuta T, Kaganovich D, Kahana A, Kain R, Kajimura S, Kalamvoki M, Kalia M, Kalinowski D, Kaludercic N, Kalvari I, Kaminska J, Kaminskyy V, Kanamori H, Kanasaki K, Kang C, Kang R, Kang S, Kaniyappan S, Kanki T, Kanneganti T, Kanthasamy A, Kantorow M, Kapuy O, Karamouzis M, Karim M, Karmakar P, Katare R, Kato M, Kaufmann S, Kauppinen A, Kaushal G, Kaushik S, Kawasaki K, Kazan K, Ke P, Keating D, Keber U, Kehrl J, Keller K, Keller C, Kemper J, Kenific C, Kepp O, Kermorgant S, Kern A, Ketteler R, Keulers T, Khalfin B, Khalil H, Khambu B, Khan S, Khandelwal V, Khandia R, Kho W, Khobrekar N, Khuansuwan S, Khundadze M, Killackey S, Kim D, Kim E, Kim H, Kim J, Kim K, Kim P, Kim S, Kimball S, Kimchi A, Kimmelman A, Kimura T, King M, Kinghorn K, Kinsey C, Kirkin V, Kirshenbaum L, Kiselev S, Kishi S, Kitamoto K, Kitaoka Y, Kitazato K, Kitsis R, Kittler J, Kjaerulff O, Klein P, Klopstock T, Klucken J, Knovelsrud H, Knorr R, Ko B, Ko F, Ko J, Kobayashi H, Kobayashi S, Koch I, Koch J, Koenig U, Kogel D, Koh Y, Koike M, Kohlwein S, Kocaturk N, Komatsu M, Konig J, Kono T, Kopp B, Korcsmaros T, Korkmaz G, Korolchuk V, Korsnes M, Koskela A, Kota J, Kotake Y, Kotler M, Kou Y, Koukourakis M, Koustas E, Kovacs A, Kovacs T, Koya D, Kozako T, Kraft C, Krainc D, Kramer H, Krasnodembskaya A, Kretz-Remy C, Kroemer G, Ktistakis N, Kuchitsu K, Kuenen S, Kuerschner L, Kukar T, Kumar A, Kumar D, Kumar S, Kume S, Kumsta C, Kundu C, Kundu M, Kunnumakkara A, Kurgan L, Kutateladze T, Kutlu O, Kwak S, Kwon H, Kwon T, Kwon Y, Kyrmizi I, La Spada A, Labonte P, Ladoire S, Laface I, Lafont F, Lagace D, Lahiri V, Lai Z, Laird A, Lakkaraju A, Lamark T, Lan S, Landajuela A, Lane D, Lane J, Lang C, Lange C, Langer R, Lapaquette P, Laporte J, LaRusso N, Lastres-Becker I, Lau W, Laurie G, Lavandero S, Law B, Law H, Layfield R, Le W, Le Stunff H, Leary A, Lebrun J, Leck L, Leduc-Gaudet J, Lee C, Lee D, Lee E, Lee G, Lee H, Lee J, Lee M, Lee S, Lee W, Lee Y, Lefebvre C, Legouis R, Lei Y, Leikin S, Leitinger G, Lemus L, Leng S, Lenoir O, Lenz G, Lenz H, Lenzi P, Leon Y, Leopoldino A, Leschczyk C, Leskela S, Letellier E, Leung C, Leung P, Leventhal J, Levine B, Lewis P, Ley K, Li B, Li D, Li J, Li K, Li L, Li M, Li P, Li Q, Li S, Li T, Li W, Li X, Li Y, Li Z, Lian J, Liang C, Liang Q, Liang W, Liang Y, Liao G, Liao L, Liao M, Liao Y, Librizzi M, Lie P, Lilly M, Lim H, Lima T, Limana F, Lin C, Lin D, Lin F, Lin J, Lin K, Lin L, Lin P, Lin Q, Lin S, Lin W, Lin X, Lin Y, Linden R, Lindner P, Ling S, Lingor P, Linnemann A, Liou Y, Lipinski M, Lipovsek S, Lira V, Lisiak N, Liton P, Liu C, Liu F, Liu H, Liu J, Liu L, Liu M, Liu Q, Liu W, Liu X, Liu Y, Livingston J, Lizard G, Lizcano J, Ljubojevic-Holzer S, LLeonart M, Llobet-Navas D, Llorente A, Lo C, Lobato-Marquez D, Long Q, Long Y, Loos B, Loos J, Lopez M, Lopez-Domenech G, Lopez-Guerrero J, Lopez-Jimenez A, Lopez-Valero I, Lorenowicz M, Lorente M, Lorincz P, Lossi L, Lotersztajn S, Lovat P, Lovell J, Lovy A, Lu G, Lu H, Lu J, Lu M, Lu S, Luciani A, Lucocq J, Ludovico P, Luftig M, Luhr M, Luis-Ravelo D, Lum J, Luna-Dulcey L, Lund A, Lund V, Lunemann J, Luningschror P, Luo 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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
13. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
14. Regional phenological models for forecasting the start and peak of the Quercus pollen season in Spain
- Author
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García-Mozo, H., Chuine, I., Aira, M.J., Belmonte, J., Bermejo, D., Díaz de la Guardia, C., Elvira, B., Gutiérrez, M., Rodríguez-Rajo, J., Ruiz, L., Trigo, M.M., Tormo, R., Valencia, R., and Galán, C.
- Published
- 2008
- Full Text
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15. Trends in grass pollen season in southern Spain
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García-Mozo, Herminia, Galán, C., Alcázar, P., de la Guardia, C. Díaz, Nieto-Lugilde, D., Recio, M., Hidalgo, P., Gónzalez-Minero, F., Ruiz, L., and Domínguez-Vilches, E.
- Published
- 2010
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16. Olive flowering phenology variation between different cultivars in Spain and Italy: modeling analysis
- Author
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Garcia-Mozo, H., Orlandi, F., Galan, C., Fornaciari, M., Romano, B., Ruiz, L., Diaz de la Guardia, C., Trigo, M. M., and Chuine, I.
- Published
- 2009
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17. Airborne-pollen map for Olea europaea L. in eastern Andalusia (Spain) using GIS: Estimation models
- Author
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Alba, F., Nieto-Lugilde, D., Comtois, P., de la Guardia, C. Díaz, De Linares, C., and Ruiz, L.
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- 2006
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18. Heat requirement for the onset of the Olea europaea L. pollen season in several sites in Andalusia and the effect of the expected future climate change
- Author
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Galán, C., García-Mozo, H., Vázquez, L., Ruiz, L., de la Guardia, C. Díaz, and Trigo, M. M.
- Published
- 2005
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19. The effect of meteorological factors on the daily variation of airborne fungal spores in Granada (southern Spain)
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Sabariego, S., Díaz de la Guardia, C., and Alba, F.
- Published
- 2000
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20. Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
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Roc, L., de Mendoza, C., Fernandez-Alonso, M., Reina, G., Soriano, V., Rodriguez, C., Vera, M., del Romero, J., Marcaida, G., Ocete, M.D., Caballero, E., Molina, I., Aguilera, A., Rodriguez-Calvino, J.J., Navarro, D., Rivero, C., Vilarino, M.D., Benito, R., Algarate, S., Gil, J., de Lejarazu, R.O., Rojo, S., Eiros, J.M., San Miguel, A., Manzardo, C., Miro, J.M., Garcia, J., Paz, I., Poveda, E., Calderon, E., Escudero, D., Trigo, M., Diz, J., Garcia-Campello, M., Rodriguez-Iglesias, M., Hernandez-Betancor, A., Martin, A.M., Ramos, J.M., Gimeno, A., Gutierrez, F., Rodriguez, J.C., Sanchez, V., Gomez-Hernando, C., Cilla, G., Perez-Trallero, E., Lopez-Aldeguer, J., Fernandez-Pereira, L., Niubo, J., Hernandez, M., Lopez-Lirola, A.M., Gomez-Sirvent, J.L., Force, L., Cifuentes, C., Perez, S., Morano, L., Raya, C., Gonzalez-Praetorius, A., Perez, J.L., Penaranda, M., Hernaez-Crespo, S., Montejo, J.M., Martinez-Sapina, A., Viciana, I., Cabezas, T., Lozano, A., Fernandez, J.M., Garcia-Bermejo, I., Gaspar, G., Garcia, R., Gorgolas, M., Vegas, C., Blas, J., Miralles, P., Valeiro, M., Aldamiz, T., Margall, N., Guardia, C., do Pico, E., Polo, I., Aguinaga, A., Ezpeleta, C., Sauleda, S., Piron, M., Gonzalez, R., Barea, L., Jimenez, A., Blanco, L., Suarez, A., Rodriguez-Avial, I., Perez-Rivilla, A., Parra, P., Fernandez, M., Trevino, A., Requena, S., Benitez-Gutierrez, L., Cuervas-Mons, V., Barreiro, P., Corral, O., and Gomez-Gallego, F.
- Abstract
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor-recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
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- 2019
21. HTLV-1 infection in solid organ transplant donors and recipients in Spain
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de Mendoza, Carmen, Roc, Lourdes, Benito, Rafael, Reina, Gabriel, Manuel Ramos, Jose, Gomez, Cesar, Aguilera, Antonio, Rodriguez-Iglesias, Manuel, Garcia-Costa, Juan, Fernandez-Alonso, Miriam, Soriano, Vicente, Rodriguez, C., Vera, M., del Romero, J., Marcaida, G., Ocete, M. D., Caballero, E., Molina, I., Rodriguez-Calvino, J. J., Navarro, D., Rivero, C., Vilarino, M. D., Algarate, S., Gil, J., Ortiz de Lejarazu, R., Rojo, S., Eiros, J. M., San Miguel, A., Manzardo, C., Miro, J. M., Garcia, J., Paz, I., Poveda, E., Calderon, E., Escudero, D., Trigo, M., Diz, J., Garcia-Campello, M., Hernandez-Betancor, A., Martin, A. M., Gimeno, A., Gutierrez, F., Rodriguez, J. C., Sanchez, V., Gomez-Hernando, C., Cilla, G., Perez-Trallero, E., Lopez-Aldeguer, J., Fernandez-Pereira, L., Niubo, J., Hernandez, M., Lopez-Lirola, A. M., Gomez-Sirvent, J. L., Force, L., Cifuentes, C., Perez, S., Morano, L., Raya, C., Gonzalez-Praetorius, A., Perez, J. L., Penaranda, M., Hernaez-Crespo, S., Montejo, J. M., Martinez-Sapina, A., Viciana, I., Cabezas, T., Lozano, A., Fernandez, J. M., Garcia-Bermejo, I., Gaspar, G., Garcia, R., Gorgolas, M., Vegas, C., Blas, J., Miralles, P., Valeiro, M., Aldamiz, T., Margall, N., Guardia, C., do Pico, E., Polo, I., Aguinaga, A., Ezpeleta, C., Sauleda, S., Piron, M., Gonzalez, R., Barea, L., Jimenez, A., Blanco, L., Suarez, A., Rodriguez-Avial, I., Perez-Rivilla, A., Parra, P., Fernandez, M., Trevino, A., Requena, S., Benitez-Gu-tierrez, L., Cuervas-Mons, V., Barreiro, P., Soriano, V., Corral, O., Gomez-Gallego, F., Spanish HTLV Network, Bioquímica y Biología Molecular, Microbiología, Medicina Preventiva, Salud Pública, Soriano, Vicente [0000-0002-4624-5199], Soriano, Vicente, [Mendoza C] Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain. Universidad CEU-San Pablo, Madrid, Spain. [Roc L] Hospital Miguel Servet, Zaragoza, Spain. [Benito R] Hospital Lozano Blesa, Zaragoza, Spain. [Reina G] Clínica Universitaria de Navarra, Pamplona, Spain. [Ramos JM] Hospital General Universitario, Alicante, Spain. [Gómez C] Complejo Hospitalario, Toledo, Spain, and Vall d'Hebron Barcelona Hospital Campus
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0301 basic medicine ,2420 Virología ,medicine.medical_treatment ,humanos ,Myelopathy ,Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies::Retrospective Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,0302 clinical medicine ,Medical microbiology ,Tropical spastic paraparesis ,Infeccions per retrovirus ,030212 general & internal medicine ,Trasplantació d'òrgans, teixits, etc - Espanya ,mediana edad ,anciano ,Leukemia ,Leucèmia ,Immunosuppression ,adulto ,Middle Aged ,Tissue Donors ,Geographic Locations::Europe::Spain [GEOGRAPHICALS] ,Infectious Diseases ,trasplante de órganos ,virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Deltaretrovirus::infecciones por HTLV-I [ENFERMEDADES] ,Cèl·lules T ,Screening ,Paraparesia espástica tropical ,Raonament basat en casos ,Ubicaciones Geográficas::Europa (Continente)::España [DENOMINACIONES GEOGRÁFICAS] ,Female ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Virus Diseases::RNA Virus Infections::Retroviridae Infections::Deltaretrovirus Infections::HTLV-I Infections [DISEASES] ,030106 microbiology ,técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes::estudios retrospectivos [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,T cells ,Asymptomatic ,Health Surveillance of Health Services::Delivery of Health Care::Patient Care::Therapeutics::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Tissue and Organ Harvesting::Organ Transplantation [HEALTH SURVEILLANCE] ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Leucemia de células T adultas ,Internal medicine ,medicine ,VIH (Virus) ,Humans ,Adult T-cell leukaemia ,lcsh:RC109-216 ,Dialysis ,Aged ,Retrospective Studies ,Transplantation ,business.industry ,HIV (Viruses) ,estudios retrospectivos ,donantes de tejidos ,Organ Transplantation ,medicine.disease ,HTLV-I Infections ,Spain ,HTLV-1 ,vigilancia sanitaria de los servicios de salud::prestación sanitaria::asistencia al paciente::terapéutica::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::extracción de tejidos y órganos::trasplante de órganos [VIGILANCIA SANITARIA] ,Trasplante ,HTLV-1 Infection ,infecciones por HTLV-I ,business - Abstract
Consortia on behalf of the Spanish HTLV Network: C. Rodríguez, M. Vera, J. del Romero, G. Marcaida, M. D. Ocete, E. Caballero, I. Molina, A. Aguilera, J. J. Rodríguez-Calviño, D. Navarro, C. Rivero, M. D. Vilariño, R. Benito, S. Algarate, J. Gil, R. Ortiz de Lejarazu, S. Rojo, J. M. Eirós, A. San Miguel, C. Manzardo, J. M. Miró, J. García, I. Paz, E. Poveda, E. Calderón, D. Escudero, M. Trigo, J. Diz, M. García-Campello, M. Rodríguez Iglesias, A. Hernández Betancor, A. M. Martín, J. M. Ramos, A. Gimeno, F. Gutiérrez, J. C. Rodríguez, V. Sánchez, C. Gómez Hernando, G. Cilla, E. Pérez Trallero, J. López Aldeguer, L. Fernández Pereira, J. Niubó, M. Hernández, A. M. López Lirola, J. L. Gómez Sirvent, L. Force, C. Cifuentes, S. Pérez, L. Morano, C. Raya, A. González Praetorius, J. L. Pérez, M. Peñaranda, S. Hernáez Crespo, J. M. Montejo, L. Roc, A. Martínez Sapiña, I. Viciana, T. Cabezas, A. Lozano, J. M. Fernández, I. García-Bermejo, G. Gaspar, R. García, M. Górgolas, C. Vegas, J. Blas, P. Miralles, M. Valeiro, T. Aldamiz, N. Margall, C. Guardia, E. do Pico, I. Polo, A. Aguinaga, C. Ezpeleta, S. Sauleda, M. Pirón, R. González, L. Barea, A. Jiménez, L. Blanco, A. Suárez, I. Rodríguez Avial, A. Pérez Rivilla, P. Parra, M. Fernández, M. Fernández Alonso, A. Treviño, S. Requena, L. Benítez Gutiérrez, V. Cuervas Mons, C. de Mendoza, P. Barreiro, V. Soriano, O. Corral & F. Gómez-Gallego, [Background]: HTLV-1 infection is a neglected disease, despite infecting 10–15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain., [Methods]: All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008., [Results]: A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic., [Conclusion]: The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy.
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- 2019
22. Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
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Roc, Lourdes, de Mendoza, Carmen, Fernandez-Alonso, Miriam, Reina, Gabriel, Soriano, Vicente, Rodriguez, C., Vera, M., del Romero, J., Marcaida, G., Ocete, M. D., Caballero, E., Molina, I, Aguilera, A., Rodriguez-Calvino, J. J., Navarro, D., Rivero, C., Vilarino, M. D., Benito, R., Algarate, S., Gil, J., Ortiz de Lejarazu, R., Rojo, S., Eiros, J. M., San Miguel, A., Manzardo, C., Miro, J. M., Garcia, J., Paz, I, Poveda, E., Calderon, E., Escudero, D., Trigo, M., Diz, J., Garcia-Campello, M., Rodriguez-Iglesias, M., Hernandez-Betancor, A., Martin, A. M., Ramos, J. M., Gimeno, A., Gutierrez, F., Rodriguez, J. C., Sanchez, V, Gomez-Hernando, C., Cilla, G., Perez-Trallero, E., Lopez-Aldeguer, J., Fernandez-Pereira, L., Niubo, J., Hernandez, M., Lopez-Lirola, A. M., Gomez-Sirvent, J. L., Force, L., Cifuentes, C., Perez, S., Morano, L., Raya, C., Gonzalez-Praetorius, A., Perez, J. L., Penaranda, M., Hernaez-Crespo, S., Montejo, J. M., Martinez-Sapina, A., Viciana, I, Cabezas, T., Lozano, A., Fernandez, J. M., Garcia-Bermejo, I, Gaspar, G., Garcia, R., Gorgolas, M., Vegas, C., Blas, J., Miralles, P., Valeiro, M., Aldamiz, T., Margall, N., Guardia, C., do Pico, E., Polo, I, Aguinaga, A., Ezpeleta, C., Sauleda, S., Piron, M., Gonzalez, R., Barea, L., Jimenez, A., Blanco, L., Suarez, A., Rodriguez-Avial, I, Perez-Rivilla, A., Parra, P., Fernandez, M., Trevino, A., Requena, S., Benitez-Gutierrez, L., Cuervas-Mons, V, Barreiro, P., Corral, O., Gomez-Gallego, F., and Spanish HTLV Network
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0301 basic medicine ,medicine.medical_specialty ,030106 microbiology ,Case Report ,Infectious and parasitic diseases ,RC109-216 ,030230 surgery ,Gastroenterology ,03 medical and health sciences ,Myelopathy ,0302 clinical medicine ,Two kidney ,myelopathy ,Internal medicine ,medicine ,Pharmacology (medical) ,antiretroviral drugs ,Kidney transplantation ,business.industry ,screening ,medicine.disease ,Transplantation ,Infectious Diseases ,Virus type ,HTLV-1 ,business ,transplantation - Abstract
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor–recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
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- 2019
23. Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
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de Mendoza, C, Piron, M, Gonzalez, R, Jimenez, A, Caballero, E, Roc, L, Benito, R, Ramos, JM, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Molina, I, Aguilera, A, Rodriguez-Calvino, JJ, Navarro, D, Rivero, C, Vilarino, MD, Algarate, S, Gil, J, de Lejarazu, RO, Rojo, S, Eiros, JM, San Miguel, A, Manzardo, C, Miro, JM, Garcia, J, Paz, I, Poveda, E, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Martin, AM, Gimeno, A, Gutierrez, F, Rodriguez, JC, Sanchez, V, Gomez-Hernando, C, Cilla, G, Perez-Trallero, E, Lopez-Aldeguer, J, Fernandez-Pereira, L, Niubo, J, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Perez, S, Morano, L, Raya, C, Gonzalez-Praetorius, A, Perez, JL, Penaranda, M, Hernaez-Crespo, S, Montejo, JM, Martinez-Sapina, A, Viciana, I, Cabezas, T, Lozano, A, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Garcia, R, Gorgolas, M, Vegas, C, Blas, J, Miralles, P, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Polo, I, Aguinaga, A, Ezpeleta, C, Sauleda, S, Torres, P, Blanco, L, Suarez, A, Rodriguez-Avial, I, Perez-Rivilla, A, Parra, P, Fernandez, M, Fernandez-Alonso, M, Trevino, A, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, Barreiro, P, Corral, O, and Gomez-Gallego, F
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myelopathy ,adult T-cell leukemia ,HTLV-1 ,screening ,epidemiology - Abstract
Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. Methods. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. Results. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Conclusions. Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses.
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- 2019
24. HIV co-infection in HTLV-1 carriers in Spain
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de Mendoza, C, Caballero, E, Aguilera, A, Benito, R, Macia, D, Garcia-Costa, J, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Molina, I, Rodriguez-Calvino, JJ, Navarro, D, Rivero, C, Vilarino, MD, Algarate, S, Gil, J, de Lejarazu, RO, Rojo, S, Eiros, JM, San Miguel, A, Manzardo, C, Mira, JM, Garcia, J, Paz, I, Poveda, E, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Martin, AM, Ramos, JM, Gimeno, A, Gutierrez, F, Rodriguez, JC, Sanchez, V, Gomez-Hernando, C, Cilla, G, Perez-Trallero, E, Lopez-Aldeguer, J, Fernandez-Pereira, L, Niubo, J, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Raya, C, Gonzalez-Praetorius, A, Perez, JL, Penaranda, M, Hernaez-Crespo, S, Montejo, JM, Roc, L, Martinez-Sapina, A, Viciana, I, Cabezas, T, Lozano, A, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Garcia, R, Gorgolas, M, Vegas, C, Blas, J, Miralles, P, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Polo, I, Aguinaga, A, Ezpeleta, C, Sauleda, S, Piron, M, Gonzalez, R, Barea, L, Jimenez, A, Blanco, L, Suarez, A, Rodriguez-Avial, I, Perez-Rivilla, A, Parra, P, Fernandez, M, Fernandez-Alonso, M, Reina, G, Trevino, A, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, Barreiro, P, Corral, O, Gomez-Gallego, F, Perez, S, Morano, L, and Spanish HTLV Network
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AIDS ,Epidemiology ,Tropical spastic paraparesis ,Adult T-cell leukemia ,virus diseases ,HIV ,HTLV ,Co-infection ,Antiretroviral therapy ,Late diagnosis - Abstract
Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain. Methods: A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection. Results: Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia). HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection. Conclusion: HIV coinfection is infrequent (< 5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.
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- 2019
25. Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015
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Martin-Nalda, A, Cebollero, A, Carrascon, A, Moreira, A, Requena-Mendez, A, Soto, AT, Martin, A, Ballester, A, Bragulat, A, Soligo, A, Bastarras, AV, Paya, A, Soriano-Arandes, A, Sorni, A, Calvo, A, Mur, A, Colomer, A, Carral, B, Trevino, B, Guarch, B, Orta, C, Rodrigo, C, Galles, C, Garrido, C, Molina, C, Mora, C, Munoz, C, Marti, C, Sanjose, C, Guardia, C, Cortes, C, Gutierrez, C, Martinez, C, Riera, C, Soler, C, Gonzalez, D, Guix, D, Mir, ES, Padilla, E, Sulleiro, E, Llurba, E, Del Amo, E, Moliner, E, Esteba, EP, Coll, E, Rodriguez, E, Monaco, E, Munoz, E, Freixas, E, Dopico, E, Sarda, E, Ballester, F, Gomez, F, Barranco, F, Ripoll, F, Fargas, FJ, Falguera, G, Fernandez-Rivas, G, Ginovart, G, Navarro, G, Garcia-Pardo, G, Lorenzo, G, Ouaarab, H, Caubet, I, Claveria, I, Sanfeliu, I, Molina, I, Blanch, J, Marti, JA, Farre, J, Gascon, J, Costa, J, Prat, JGI, Fulquet, J, Jove, JP, Armengol, J, Riera, JC, Villar, J, Torrent, LS, De La Torre, L, Delgado, L, Valerio, L, Montsant, L, Basile, L, Mayol, L, Valls, ME, Vives, MA, Sauca, MG, Coll, M, Pinazo, MJ, Ferri, MJ, Vidal, MJ, Villegas, ML, Anquela, MAS, Monsonis, M, Blasco, MP, Perez-Moreno, MO, Sabates, MC, Mendez, M, Navarro, M, Urcola, M, Lora, M, Almirall, M, Arasa, M, Alaball, MV, Carulla, M, Jane, M, Ribell-Bachs, M, Abella, M, Gallego, M, Prat, N, Rius, N, Bosh, NP, Garcia, P, Araujo, P, Sole, P, Ciruela, P, Villalobos, P, Almirall, R, Diaz, R, Puigarnau, R, Serra, R, Diez, R, Bosch, ST, Franch, S, Vega, S, Mani, SG, Juncosa, T, Pineda, V, Fumado, V, and Urquizu, X
- Abstract
Background: Chagas disease is endemic in Latin America and affects 8 million people worldwide. In 2010, Catalonia introduced systematic public health surveillance to detect and treat congenital Chagas disease. Aim: The objective was to evaluate the health outcomes of the congenital Chagas disease screening programme during the first 6 years (2010-2015) after its introduction in Catalonia. Methods: In a surveillance system, we screened pregnant women and newborns and other children of positive mothers, and treated Chagas-positive newborns and children. Diagnosis was confirmed for pregnant women and children with two positive serological tests and for newborns with microhaematocrit and/or PCR at birth or serology at age 9 months. Results: From 2010 to 2015, the estimated screening coverage rate increased from 68.4% to 88.6%. In this period, 33,469 pregnant women were tested for Trypanosoma cruzi and 937 positive cases were diagnosed. The overall prevalence was 2.8 cases per loo pregnancies per year (15.8 in Bolivian women). We followed 82.8% of newborns until serological testing at age 9-12 months and 28 were diagnosed with Chagas disease (congenital transmission rate: 4.17%). Of 518 siblings, 178 (34.3%) were tested and 14 (7.8%) were positive for T. cruzi. Having other children with Chagas disease and the heart clinical form of Chagas disease were maternal risk factors associated with congenital T. cruzi infection (p < 0.05). Conclusion: The increased screening coverage rate indicates consolidation of the programme in Catalonia. The rate of Chagas disease congenital transmission in Catalonia is in accordance with the range in non-endemic countries.
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- 2019
26. HTLV testing of solid organ transplant donors
- Author
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de Mendoza, C, Roc, L, Fernandez-Alonso, M, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Caballero, E, Aguilera, A, Rodriguez-Calvino, JJ, Rivero, C, Vilarino, MD, Benito, R, Algarate, S, de Lejarazu, RO, Rojo, S, Eiros, JM, Ramos, C, Manzardo, C, Miro, JM, Garcia-Costa, J, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Martin, AM, Ramos, JM, Gimeno, A, Sanchez, V, Guzman, M, Gomez-Hernando, C, Echeverria, MJ, Cilla, G, Fernandez-Pereira, L, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Perez, S, Morano, L, Raya, C, Gonzalez-Praetorius, A, Penaranda, M, Nieto, MC, Montejo, JM, Viciana, I, Cabezas, T, Lozano, A, Perez-Camacho, I, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Tellez, R, Gorgolas, M, Perez, L, Monsalvo, S, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Sauleda, S, Piron, M, Gonzalez, R, Richart, A, Barea, L, Jimenez, A, Blanco, L, Suarez, A, Rodriguez-Avial, I, Parra, P, Fernandez, M, Reina, G, Trevino, A, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, Barreiro, P, Corral, O, and Gomez-Gallego, F
- Published
- 2019
27. Detection of airborne allergen (Ole e 1) in relation to Olea europaea pollen in S Spain
- Author
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De Linares, C., Nieto-Lugilde, D., Alba, F., de la Guardia, C. Díaz, Galán, C., and Trigo, M. M.
- Published
- 2007
28. Antibiotic susceptibility, mechanisms of macrolide resistance and clonal relationship in group B streptococci: P1225
- Author
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González, J. J., Andreu, A., Alomar, P., Blanco, M. A., Bordes, A., Bosch, J., Cacho, J., Cid, A., Coira, A., de Cueto, M., Dopico, E., García-Arenzana, J. M., Gil-Setas, A., Gimeno, C., Guardia, C., Illescas, S., Juncosa, T., Lite, J., Martínez, R., Orden, B., Peréz-Pascual, M., Rebollo, M., de la Rosa, M., Rodriguez-Mayo, M., Sanfeliu, I., Sanz, F., Villanueva, P., and Viñas, L.
- Published
- 2005
29. A new taxon in the genusMoehringia (Caryophyllaceae)
- Author
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de la Guardia, C. Diaz, Mota, J. F., and Valle, F.
- Published
- 1991
- Full Text
- View/download PDF
30. Alternative chirurgicale pour les fractures de l’extrémité inférieure du radius — le fixateur Radio Radial
- Author
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Guardia, C., primary
- Published
- 2018
- Full Text
- View/download PDF
31. Phase change material cement-lime mortars for thermal retrofitting of facades
- Author
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Guardia, C., Barluenga, G., and Palomar, I.
- Abstract
The poor thermal performance of many dwelling units built from 1940 to 1980 produces a low energy efficiency under the present thermal standards. In order to fulfil comfort and energy efficiency requirements, these facades need to be retrofitted. In many cases, External Thermal Insulation Composite System (ETICS) are used to increase thermal insulation, although this solution does not consider the thermal inertia. New mortars with improved thermal insulation and inertia are investigated as an innovative solution. Twelve cement-lime mortars were designed, using: white cement, air lime, siliceous aggregate (0-4 mm), lightweight aggregate (LWA) (expanded perlite), short cellulose fibres and 10 and 20% of a Phase Change Material (PCM) - microencapsulated paraffin wax. PCM’s nominal melting temperature was 23 ± 1 °C. An experimental program was carried out to assess the effect of PCM on the physical and thermal performance of the mortars. Two different scenarios were considered to evaluate the temperature effect on the PCM-mortar performance. Bulk density, open porosity, capillary absorption, vapour permeability, thermal conductivity and compressive strength were characterized. PCM produced significant changes on the mortar thermal properties and a synergetic effect of PCM and LWA was identified., Academic Journal of Civil Engineering, Vol 35 No 2 (2017): Special Issue - ICBBM 2017
- Published
- 2017
- Full Text
- View/download PDF
32. A new taxon in the genus Moehringia (Caryophyllaceae)
- Author
-
de la Guardia, C. Diaz, Mota, J. F., and Valle, F.
- Published
- 1991
33. Pinus pollen season trend in South Spain
- Author
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Velasco-Jiménez, M. J., primary, Alcázar, P., additional, Valenzuela, L. R., additional, Gharbi, D., additional, Díaz de la Guardia, C., additional, and Galán, C., additional
- Published
- 2017
- Full Text
- View/download PDF
34. The Burden of Neglected HIV-2 and HTLV-1 Infections in Spain
- Author
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Treviño A, Caballero E, de Mendoza C, Aguilera A, Pirón M, Soriano V, Rodríguez M, del Romero J, Marcaida G, Ocete MD, Molina I, Rodríguez-Calviño JJ, Navarro D, Regueiro B, Benito R, Algarate S, Gil J, Ortiz de Lejarazu R, Rojo S, Eirós JM, Manzardo C, Miró JM, García J, Paz I, Poveda E, Calderón E, Mateos M, Dronda F, Escudero D, Trigo M, Diz J, García-Campello M, Rodríguez-Iglesias M, Hernández-Betancor A, Martín AM, Ramos JM, Gimeno A, Gutiérrez F, Rodríguez JC, Sanchez V, Gómez-Hernando C, Cilla G, Pérez-Trallero E, López-Aldeguer J, Fernández-Pereira L, Niubó J, Hernández M, López-Lirola AM, Gómez-Sirvent JL, Force L, Cifuentes C, Pérez S, Morano L, Raya C, González-Praetorius A, Pérez JL, Peñaranda M, Hernáez-Crespo S, Montejo JM, Roc L, Martínez-Sapiña A, Viciana I, Cabezas T, Lozano A, Fernández JM, García-Bermejo I, Gaspar G, García R, Górgolas M, Vegas MC, Vegas C, Blas J, Miralles P, Aldamiz T, Margall N, Guardia C, Do Pico E, Polo I, Aguinaga A, Ezpeleta C, Sauleda S, Torres P, Jiménez A, Blanco L, González R, Suárez A, Requena S, Benítez-Gutiérrez L, Cuervas-Mons V, and Barreiro P
- Subjects
virus diseases - Abstract
HIV-2 and HTLV-1 infections are globally less frequent than those produced by HIV-1, the classical AIDS agent. In Spain and up to the end of 2014, a total of 310 cases of HIV-2, 274 of HTLV-1, and 776 of HTLV-2 infections had been reported. No cases of HTLV-3 or HTLV-4 infections have been identified so far in Spain. Most persons infected with HIV-2 or HTLV-1 acknowledge epidemiological risk factors for contagion, such as originating from or living in endemic regions and/or having had sexual partners from those areas. However, risk factors could not be recognized in up to 20-25% of carriers in Spain. Thus, it seems worth keeping a high level of clinical suspicion in order to identify earlier these neglected human retroviral infections, since diagnostic procedures and antiviral treatment are specific for each of these agents. In this article we summarize the major contributions reported at the meeting of the Spanish Group for HIV-2/HTLV held in Madrid in December 2014
- Published
- 2015
35. Group B streptococcal early-onset neonatal sepsis in the area of Barcelona (2004-2010). Analysis of missed opportunities for prevention
- Author
-
Gimenez, M, Sanfeliu, I, Sierra, M, Dopico, E, Juncosa, T, Andreu, A, Lite, J, Guardia, C, Sanchez, F, and Bosch, J
- Subjects
Early-onset neonatal sepsis ,Prevention ,Intra-partum chemoprophylaxis ,Streptococcus agalactiae - Abstract
Objectives: To study the evolution of the incidence of early-onset neonatal sepsis (EOS) by Streptococcus agalactiae in the area of Barcelona and to analyze failure of compliance with the prevention protocol. Methods: A retrospective review was carried out on EOS cases in 8 Health-Care Centers in the Barcelona area between 2004 and 2010. Results: Forty-nine newborns from 48 mothers were diagnosed with EOS. The incidence was 0.29% living newborns (0.18-0.47%.), with no significant differences in the fluctuations along the 7 years. The mortality rate was 8.16%. In 68.5% cases the maternal colonization studies were negative, and in 21% these studies were not performed. No risk factors were detected in 58.3% of pregnant women, and 22.9% of births were premature. In 58% of cases intra-partum antibiotic prophylaxis was not administered because it was not indicated, and in 42% due to failure to follow the protocol (3 strains were resistant to erythromycin). Resistance to clindamycin was 33.3%. The Streptococcus agalactiae serotypes more frequently isolated were in, v, and ia. Conclusions: No significant changes were detected in the incidence of Streptococcus agalactiae EOS in the 7 years of the study. The increased sensitivity of screening methods with the use of molecular techniques, the performance of susceptibility testing of strains isolated from pregnant women, and the improvement of communication between Health-Care Centers, can contribute to a better implementation of the protocol, as well as to reduce the incidence of EOS.(C) 2014 Elsevier Espana, S.L.U. and Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.
- Published
- 2015
36. Modeling olive pollen intensity in the Mediterranean region through analysis of emission sources
- Author
-
Rojo, J., primary, Orlandi, F., additional, Pérez-Badia, R., additional, Aguilera, F., additional, Ben Dhiab, A., additional, Bouziane, H., additional, Díaz de la Guardia, C., additional, Galán, C., additional, Gutiérrez-Bustillo, A.M., additional, Moreno-Grau, S., additional, Msallem, M., additional, Trigo, M.M., additional, and Fornaciari, M., additional
- Published
- 2016
- Full Text
- View/download PDF
37. Airborne pollen trends in the Iberian Peninsula
- Author
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Galán, C., primary, Alcázar, P., additional, Oteros, J., additional, García-Mozo, H., additional, Aira, M.J., additional, Belmonte, J., additional, Diaz de la Guardia, C., additional, Fernández-González, D., additional, Gutierrez-Bustillo, M., additional, Moreno-Grau, S., additional, Pérez-Badía, R., additional, Rodríguez-Rajo, J., additional, Ruiz-Valenzuela, L., additional, Tormo, R., additional, Trigo, M.M., additional, and Domínguez-Vilches, E., additional
- Published
- 2016
- Full Text
- View/download PDF
38. Anatomical and functional retinal changes in multiple sclerosis
- Author
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Cennamo, G, primary, Romano, M R, additional, Vecchio, E C, additional, Minervino, C, additional, della Guardia, C, additional, Velotti, N, additional, Carotenuto, A, additional, Montella, S, additional, Orefice, G, additional, and Cennamo, G, additional
- Published
- 2015
- Full Text
- View/download PDF
39. Pinus pollen season trend in South Spain.
- Author
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Velasco-Jiménez, M. J., Alcázar, P., Valenzuela, L. R., Gharbi, D., Díaz de la Guardia, C., and Galán, C.
- Subjects
PINE ,POLLEN ,ORNAMENTAL plants ,VEGETATION & climate ,CLIMATE change - Abstract
In Andalusia (southern Spain), Pinus species are found in mountainous areas and nature reserves, though some species are also grown as ornamentals in cities. Annual airborne pollen trends are regarded as an indicator of variations in climate prompted by overall climate change. Airborne pollen concentration also provides a useful tool for analyzing alterations in the distribution of vegetation in response to environmental factors and to changes in land use. The present study analyzed the Pinus pollen season over 22 years (1993-2014) in 4 Andalusian cities (Córdoba, Granada, Jaén, and Málaga), and examined correlations between airborne pollen concentrations and meteorological parameters (temperature and rainfall). Pinus pollen season lasted from March to June, starting first in Málaga and later in eastern Andalusia. Differences between the pollen curves for each city were attributable to differing proportions of pine species in each province. Temperatures during the months prior to flowering tended to fall, prompting delayed onset of the pollen season in most cities. No significant results were observed for rainfall patterns in most cities. Total pollen concentrations increased at most sites, suggesting that the recorded decline in pine-nut output was not influenced by flowering rates, but to the impact of a local pest. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
40. Analisi numerico-sperimentale del processo di formatura incrementale di lamiere metalliche
- Author
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Fontanari, V., Monelli, BERNARDO DISMA, Guardia, C., Bruschi, S., and Fuganti, A.
- Published
- 2011
41. Posaconazole susceptibility of clinical yeast isolates determined by an agar diffusion and microdilution method
- Author
-
Carrillo-Muñoz, A.J., Tur-Tur, C., Quindós, G., Eraso, E., del Valle, O., Santos, P., Estivill, D., Guardia, C., Hernández-Molina, J.M., and Giusiano, G.
- Published
- 2011
- Full Text
- View/download PDF
42. Quercus pollen season dynamics in the Iberian peninsula: response to meteorological parameters and possible consequences of climate change
- Author
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García-Mozo, H., Galán, C., Jato, V., Belmonte, J., Díaz La Guardia, C., Fernández, D., Gutiérrez, M., Aira, M. J., Roure, J. M., Ruiz, L., M.Mar Trigo Pérez, and Domínguez-Vilches, E.
- Subjects
Air Pollutants ,Quercus ,Spain ,Air Pollution ,Climate ,Hypersensitivity ,Humans ,Pollen ,Seasons ,Allergens ,Environmental Monitoring ,Forecasting ,Retrospective Studies - Abstract
The main characteristics of the Quercus pollination season were studied in 14 different localities of the Iberian Peninsula from 1992-2004. Results show that Quercus flowering season has tended to start earlier in recent years, probably due to the increased temperatures in the pre-flowering period, detected at study sites over the second half of the 20th century. A Growing Degree Days forecasting model was used, together with future meteorological data forecast using the Regional Climate Model developed by the Hadley Meteorological Centre, in order to determine the expected advance in the start of Quercus pollination in future years. At each study site, airborne pollen curves presented a similar pattern in all study years, with different peaks over the season attributable in many cases to the presence of several species. High pollen concentrations were recorded, particularly at Mediterranean sites. This study also proposes forecasting models to predict both daily pollen values and annual pollen emission. All models were externally validated using data for 2001 and 2004, with acceptable results. Finally, the impact of the highly-likely climate change on Iberian Quercus pollen concentration values was studied by applying RCM meteorological data for different future years, 2025, 2050, 2075 and 2099. Results indicate that under a doubled CO(2) scenario at the end of the 21st century Quercus pollination season could start on average one month earlier and airborne pollen concentrations will increase by 50 % with respect to current levels, with higher values in Mediterranean inland areas.
- Published
- 2007
43. Análisis aerobiológico del polen de Cupressaceae en Granada (sureste P. Ibérica): su repercusión en la población atópica
- Author
-
Díaz de la Guardia, C., Alba, F., De Linares, C., Nieto-Lugilde, D., Girón, F., Lara, M.A., Rojas, M.J., Martínez, P., and Martínez Cañavate, A.
- Subjects
Palynology - Abstract
XV lnternational A.P.L.E. Symposium of Palynology
- Published
- 2006
44. Espectro polínico de la franja litoral en la provincia de Granada: periodo estudiado 2003-2005
- Author
-
Nieto-Lugilde, D., Alba, F., De Linares, C., and Díaz de la Guardia, C.
- Subjects
Palynology - Abstract
XV lnternational A.P.L.E. Symposium of Palynology
- Published
- 2006
45. Estudio de la actividad alergénica de Olea europaea L. y su relación con ingresos de pacientes en los Servicios de Urgencias (Hospital San Cecilio de Granada)
- Author
-
De Linares, C., Nieto-Lugilde, D., Alba, F., and Díaz de la Guardia, C.
- Subjects
Alergógenos ,Palynology - Abstract
XV lnternational A.P.L.E. Symposium of Palynology
- Published
- 2006
46. Análisis y tendencias del polen de Chenopodiáceas-Amarantáceas en la atmósfera de cuatro ciudades del sur de España
- Author
-
Recio, M., Trigo, M.M., Díaz de la Guardia, C., Alba, F., Galán, Carmen, Alcázar, P., Cariñanos, P., Sabariego, S., De Linares, C., Docampo, S., Melgar, M., and Cabezudo, B.
- Subjects
Palynology - Abstract
XV lnternational A.P.L.E. Symposium of Palynology
- Published
- 2006
47. Olive flowering phenology variation between different varieties in Spain and Italy: modelling analysis
- Author
-
Garcia Mozo, H., FORNACIARI DA PASSANO, Marco, Galan, C., Orlandi, Fabio, Romano, Bruno, Ruiz, L., Diaz De La Guardia, C., Trigo, M. M., and Chuine, I.
- Published
- 2006
48. Interlaboratory Reproducibility and Proficiency Testing within the Human Papillomavirus Cervical Cancer Screening Program in Catalonia, Spain
- Author
-
Ibanez, R., primary, Felez-Sanchez, M., additional, Godinez, J. M., additional, Guardia, C., additional, Caballero, E., additional, Juve, R., additional, Combalia, N., additional, Bellosillo, B., additional, Cuevas, D., additional, Moreno-Crespi, J., additional, Pons, L., additional, Autonell, J., additional, Gutierrez, C., additional, Ordi, J., additional, de Sanjose, S., additional, and Bravo, I. G., additional
- Published
- 2014
- Full Text
- View/download PDF
49. Aerobiological dynamics of the Cupressaceae pollen in Spain, 1992-98
- Author
-
Belmonte, Jordina, Canela, M., Guàrdia, R., Guàrdia, R.A., Sbai, L., Vendrell, M., Cariñanos, P., Díaz de la Guardia, C., Dopazo, A., Fernández, D., Gutiérrez, M., and Trigo, M.M.
- Subjects
Polen ,Botánica ,Palinología - Published
- 1999
50. Variations in the main pollen season of Olea Europaea L. at selected sites in the Iberian Peninsula
- Author
-
Díaz de la Guardia, C., Galán, Carmen, Domínguez Vilches, E., Alba, F., Ruiz, L., Sabariego, S., Recio Criado, M., Fernández-González, D., Méndez, J., Vendrell, M., and Gutiérrez Bustillo, M.
- Subjects
Polen ,Botánica ,Palinología - Published
- 1999
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