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In this study, particle-reinforced aluminium matrix composites (PRAMCs) of an Al–Cu–Li alloy were prepared using nano-sized TiB₂+TiC particles. The relationship between TiB₂+TiC nanoparticles and T1 precipitates during the ageing process, as well as the influence of TiC + TiB₂ particles on the growth process of T1 precipitates during the ageing process, were investigated. The grain sizes of the A0 and A1 samples were found to be 249.89 μm and 86.42 μm, respectively. The dislocation density is greater in the deformed A1 sample. The coefficient of thermal expansion (CTE) effect generated by TiC and TiB₂ particles stimulates the precipitation process of T1 precipitates. The A1 alloy reached the peak ageing state in a shorter time and yielded a greater number of T1 precipitates. The precipitation process of T1 precipitate is: SSSS→T1P→T1. The transition from T1P (face-centered cubic, FCC) to T1 (hexagonal close packing, HCP) entails a modification in the order of packing. The recently formed T1P precipitate is attached to the established T1 precipitate and extends along the c-axis through the shared copper-rich layer that has formed on both sides of the mature T1 precipitate. The mechanical properties of sample A1 are optimal at T = 22h, with a yield strength, tensile strength, and elongation of 520 MPa, 553 MPa, and 8.2%, respectively. In comparison to the A0 sample, the yield strength and tensile strength exhibited an increase of 5.05% and 5.13%, respectively.

In this study, three types of three-layer functionally graded materials (FGMs) were designed by mainting the average content of the reinforcement constant and changing the span of the composition. The B4C particle-reinforced Al-matrix FGMs and a homogeneous composite (HC) with the same average composition were prepared using the laser additive manufacturing technique. The FGMs had a higher average secondary-phase content and grain size than the HC. Large (black) and reticulated (white) secondary phases corresponding to B4C phase, T phase, and MgZn2 were observed in the as-deposited FGM samples. The content of the secondary phase in the middle layer was generally low. The bottom layer, which was in direct contact with the substrate, exhibited the smallest grain size. The hardness and wear resistance significantly improved owing to the high B4C content in the top layer. The flexural behaviors of each layer of the FGM in different directions were systematically studied. The plasticity of the single-layer material decreased with increase in the B4C content. When the bottom layer had a high B4C content, the flexural ability significantly reduced. Among all the samples, G2 with 8% B4C particle content in the top layer exhibited the best comprehensive mechanical properties. The hardness value, wear rate of the top layer, maximum bending stress, and maximum bending strain of the FGM were 177.5 HV, 0.367 × 10−3mm3/(N·m), 585.6 MPa, and 7.36%, respectively. This study can provide a reference value for the future design and development of wear-resistant gradient materials for aerospace applications.

Three types of 7185+TiB2/TiC aluminum matrix composites with different Zn/Mg ratios were prepared in this work through a water-cooled copper casting process. The effects of Zn/Mg ratio on the microstructure and mechanical properties of 20-mm-thick composites were studied by optical microscopy, electron back scattering diffraction, transmission electron microscopy, and tensile mechanical testing. The results showed that the addition of appropriate TiB2/TiC particles refined the as-cast microstructure of the alloy, and with a decrease in Zn/Mg ratio, the grain size distribution became more uniform, the crystalline phase content gradually increased, and the uniformity of the alloy increased. After aging, as the Zn/Mg ratio decreased, the size of the precipitated phase decreased, and the strengthening effect of the alloy improved. The tensile strengths of the surface layer, 1/4 layer, and center position of the A3 alloy were 558, 568, and 572 MPa, respectively. The strength difference among the different thickness layers was the smallest, and the elongation rate was greater than 12%, resulting in the best uniformity.

Abstract The deltoid muscle and rotator cuff tissue are structural components that maintain the dynamic stability of the shoulder joint. However, atrophy of the deltoid muscle may affect the stability of the shoulder joint, which in turn alters the mechanical distribution of rotator cuff tissue. Currently, the effect of muscle volume changes in the deltoid muscle on reducing the load on the rotator cuff tissue is still unknown. Therefore, this paper intends to analyze the mechanical changes of rotator cuff tissue by deltoid muscle atrophy through finite elements. Based on previously published finite element shoulder models, the deltoid muscle was modeled by constructing deltoid muscle models with different degrees of atrophy as, 100% deltoid muscle (Group 1), 80% deltoid muscle (Group 2), and 50% deltoid muscle (Group 3), respectively. The three models were given the same external load to simulate glenohumeral joint abduction, and the stress changes in the rotator cuff tissue were analyzed and recorded. In all three models, the stress in the rotator cuff tissue showed different degrees of increase with the increase of abduction angle, especially in the supraspinatus muscle. At 90° of glenohumeral abduction, supraspinatus stress increased by 58% and 118% in Group 2 and Group 3, respectively, compared with Group 1; In the subscapularis, the stress in Group 3 increased by 59% and 25% compared with Group 1 and Group 2, respectively. In addition, the stress of the infraspinatus muscle and teres minor muscle in Group 2 and Group 3 were higher than that in Group 1 during the abduction angle from 30° to 90°. Deltoid atrophy alters the abduction movement pattern of the glenohumeral joint. During glenohumeral abduction activity, deltoid atrophy significantly increases the stress on the rotator cuff tissue, whereas normal deltoid volume helps maintain the mechanical balance of the rotator cuff tissue.

BackgroundIn recent years, the number of artificial cervical disc replacements has increased, and paravertebral ectopic ossification is a common complication. Although the exact mechanism is not clear, some studies suggest that it is related to the concentration of tissue stress caused by incomplete coverage of the trailing edge of the endplate. Therefore, this study performed a quantitative analysis to compare the biomechanical effects of different sagittal distances at the posterior edge of the endplate of the upper and lower prosthesis on the cervical spine and to explore the mechanical response of incomplete coverage of the posterior edge of the endplate on the paravertebral tissues.MethodsA C2-C7 nonlinear finite element model of the cervical spine was established and validated. Based on the cervical spine model, cervical disc replacement surgery models were constructed with different distances of sagittal distance at the posterior edge of the upper prosthetic endplate (0, 1, 2, 3 mm, respectively) and sagittal distance at the posterior edge of the lower prosthetic endplate (1, 2, 3 mm, respectively). Each model was subjected to the same 1Nm torque and 73.6N driven compressive load. Range of motion (ROM), intervertebral disc pressure (IDP), facet joint force (FJF), and endplate stress were measured at the cervical surgical and other segments.ResultsCompared to the intact cervical spine model, the sagittal distance of the posterior edge of the prosthesis endplate at different distances increased the stress on the intervertebral disc and the capsular joint in the adjacent vertebral body segments to different degrees, especially in extension. In different directions of motion, the posterior margin sagittal distance of the posterior edge of the endplate of the lower prosthesis has a greater mechanical influence on the cervical spine compared to the posterior margin sagittal distance of the posterior edge of the endplate of the upper prosthesis. Compared with the intact model, the biomechanical parameters (ROM, FJF, endplate stress) of the C5-C6 segment increased the most when the sagittal distance of the posterior edge of the endplate of the upper prosthesis was 3 mm. Compared with the intact model, the maximum intervertebral disc stress of C4-C5 and C6-C7 was 0.57 MPa and 0.53 MPa, respectively, when the sagittal distance of the posterior edge of the upper prosthetic endplate was 3 mm.ConclusionAfter the sagittal distance of the posterior edge of the prosthetic endplate was completely covered, the mechanical influence of the entire cervical spine was low. The sagittal distance at the posterior edge of the endplate of different sizes changed the motion pattern and load distribution of the implanted segment to some extent. When the sagittal distance between the prosthesis and the upper endplate was greater than or equal to 3 mm, the mechanical indices of the implanted segment increased significantly, increasing the risk of local tissue injury, especially during extension motion. Compared to the sagittal distance at the posterior edge of the endplate of the lower prosthesis, increasing the sagittal distance at the posterior edge of the endplate of the upper prosthesis has a greater effect on the mechanics of the cervical spine.

Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characterized by central nervous system dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs) are highly abundant in the mammalian brain. Although their precise expression and function remain unknown, they have been hypothesized to regulate transcriptional and post-transcriptional gene expression. In this investigation, we comprehensively analyzed whether restraint stress for 2 days altered the circRNA expression profile in the amygdala of male rats. The impact of restraint stress on behavior was evaluated using an elevated plus maze and open field test. Serum corticosterone levels were measured using an enzyme-linked immunosorbent assay. A total of 10,670 circRNAs were identified using RNA sequencing. Ten circRNAs were validated by reverse transcription and quantitative polymerase chain reaction analysis. Gene ontology and Kyoto encyclopedia of genes and genomes pathway analyzes supported the notion that genes associated with differentially expressed circRNAs are primarily implicated in neuronal activity and neurotransmitter transport. Moreover, the three differentially expressed circRNAs showed high specificity in the amygdala. Overall, these findings indicate that differentially expressed circRNAs are highly enriched in the amygdala and offer a potential direction for further research on restraint stress.

BackgroundHealth workers involved in the fight to prevent the COVID-19 outbreak were exposed to hazards. Detailed information on mental health problems in different medical occupations is crucial. To examined the prevalence of mental health issues in three medical occupations as well as the relationships between mental health problems and correlates in each occupation.MethodsThis study utilizing the Questionnaire Star program was conducted among medical workers working at medical institutions in China from February 17 to 24, 2020. The Self-Reporting Questionnaire (SRQ-20), the Zung Self-rating Anxiety Scale (SAS), and the Zung Self-rating Depression Scale (SDS) were used to assess mental health problems.ResultsThe prevalence of any mental health problems in the three occupations was 43.6, 34.6, and 32.9% for nurses, paramedical workers (PMWs), and doctors, respectively. Three occupations shared some correlates, such as being overworked, not having enough time to rest, support from colleagues, and previous mental health status. There were specific factors for each occupation. For doctors, age, educational level, living status, support from family, and previous physical status were related factors in mental health problems. Working in a designated hospital for treating COVID-19, having COVID-19 event exposures, and receiving support from family were associated with the mental health problems of the nurses. PMWs’ mental health problems was linked to educational level and care from supervisors or heads of department.ConclusionDifferent medical occupations have distinct impacts on mental health issues. Policy makers and mental health professionals working to prepare for potential disease outbreaks should be aware of multiple factors in different occupations.

To explore high temperature ductility, a new Mg-2.70Zn-1.34Y-0.37Ca-0.02Zr (wt.%) alloy has been fabricated by novel multidirectional forging (MDF) and hot rolling. The microstructure and mechanical properties were investigated. The average grain size of MDF + hot rolled alloy is 10.89 ± 0.90 μm refined from the as-cast average grain size of 60.03 ± 0.72 μm. The ultimate tensile strength of 260.51 ± 1.03 MPa, yield strength of 192.29 ± 1.21 MPa, and elongation of 17.83 ± 0.72 % were obtained at room temperature. For high temperature tensile behavior, microstructural examination revealed that continuous dynamic recrystallization and discontinuous dynamic recrystallization are the main softening mechanism in the temperature range of 573–673 K, while dynamic grain growth with bimodal grains and twins is discovered at 723 K in this alloy. X-ray diffraction and scanning electron microscopy –energy dispersive spectroscopy examinations revealed that the constituent phases are composed of α-Mg solid solution and intermetallic compounds of Ca2Mg6Zn3, Mg3YZn6 (I-phase), and Mg3Zn3Y2 (W-phase). The microstructural evolution, such as dynamic recrystallization and dynamic grain growth at desired tensile temperatures, is related to the thermal stability of constituent phases. The elongation to failure of 215.4 % was demonstrated at 673 K and 1.67 × 10−2 s−1, exhibiting high strain rate quasi-superplasticity. A power-law constitutive equation was established. The deformation activation energy of 177.948 kJ/mol and stress exponent of 4.494 revealed that the dominant deformation mechanism of this alloy at elevated temperatures of 573–723 K is dislocation climb controlled by lattice diffusion.

The evolution of the microstructure, texture and mechanical properties of the Al–Cu–Li alloy sheets by nanoscale TiC + TiB2 ceramic particles during solid solution treatment was systematically investigated by characterization, texture measurements and mechanical performance tests. The yield strength, tensile strength, and elongation of the A1 alloy with the addition of nanoscale TiC + TiB2 ceramic particles under T4P conditions were 312 MPa, 420 MPa, and 21.9%, respectively, which were 35.6%, 27.6%, and 2.8% higher than those of the A0 alloy, respectively. The recrystallization mechanism of both alloys was mainly the particle stimulated nucleation (PSN) mechanism, but the nanoscale TiC + TiB2 in the A1 alloy led to a stronger Zener dragging effect, which hindered the growth of CubeND nuclei, and P-oriented grains dominated. Thus, the A0 alloy sheet was dominated by CubeND components, while the A1 alloy sheet was dominated by P recrystallized grains, which led to the two alloy sheets showing opposite variation trends of the deep drawing properties with increasing solid solution treatment time. The short-time solid-solution process is more likely to provide better properties to the alloy with TiC + TiB2 added particles better properties in terms of various aspects, such as microstructure, mechanical properties, and electrical conductivity.

Abstract Background Associations between adverse childhood experiences (ACEs) and common psychiatric disorders among older Chinese individuals have not been well reported. The objectives of this study are to examine the prevalence of ACEs and the associations of ACEs with common psychiatric disorders among older adults in China. Methods The study used data from the China Mental Health Survey (CMHS), a nationally representative epidemiological survey, which used computer-assisted personal interviewing (CAPI), logistic regression models were used to examine community-based adult psychiatric disorders and associated risk factors. Finally, 2,317 individuals aged 60 years or over were included in the CMHS. The national prevalence of ACEs in older adults were estimated and logistic regression were used to analyse the association between ACEs and past-year psychiatric disorders. Results Prevalence of ACEs among older adults in China was 18.1%. The three most common types of ACEs were neglect (11.6%), domestic violence (9.2%), and parental loss (9.1%). This study proved the association between ACEs and common past-year psychiatric disorders in older adults. ACEs increased the risk of past-year psychiatric disorders in older adults. After adjustment for age, sex, marital status, employment status, education, rural or urban residence, region, and physical diseases, the association between ACEs and past-year psychiatric disorders were still significant. Conclusions ACEs are linked to an increased risk for past-year psychiatric disorders in older adults. ACEs may have long-term effects on older adults’ mental well-being. Preventing ACEs may help reduce possible adverse health outcomes in later life.

Objectives: Accumulating evidence indicates a strong link between knee osteoarthritis (KOA) and sarcopenia. However, the mechanisms involved have not yet been elucidated. This study primarily aims to explore the molecular mechanisms that explain the connection between these 2 disorders. Methods: The gene expression profiles for KOA and sarcopenia were obtained from the Gene Expression Omnibus database, specifically from GSE55235, GSE169077, and GSE1408. Various bioinformatics techniques were employed to identify and analyze common differentially expressed genes (DEGs) across the 3 datasets. The techniques involved the analysis of Gene Ontology and pathways to enhance understanding, examining protein-protein interaction (PPI) networks, and identifying hub genes. In addition, we constructed the network of interactions between transcription factors (TFs) and genes, the co-regulatory network of TFs and miRNAs for hub genes, and predicted potential drugs. Results: In total, 14 common DEGs were found between KOA and sarcopenia. Detailed information on biological processes and signaling pathways of common DEGs was obtained through enrichment analysis. After performing PPI network analysis, we discovered 4 hub genes (FOXO3, BCL6, CDKN1A, and CEBPB). Subsequently, we developed coregulatory networks for these hub genes involving TF-gene and TF-miRNA interactions. Finally, we identified 10 potential chemical compounds. Conclusions: By conducting bioinformatics analysis, our study has successfully identified common gene interaction networks between KOA and sarcopenia. The potential of these findings to offer revolutionary understanding into the common development of these 2 conditions could lead to the identification of valuable targets for therapy.

This study investigated the effect of intermediate annealing (IA) during a special thermo-mechanical treatment on the microstructure and properties of 7185 Al alloy. The results show that after IA, many sub-structures are formed in the alloy and many particles are precipitated. The particle size increases and the width of the dislocation wall becomes narrower with increasing IA time and temperature. After the second stage of deformation, the dislocations are ordered again and generate micro shear bands (MSBs). The final T6 treated alloy under IA2 process (holding time for 40 min at 400 °C) has good plasticity and corrosion resistance. The tensile strength is 523 MPa, the yield strength is 458 MPa, the elongation is 17.6%, the depth of intergranular corrosion layer is 15.6 μm, and the corrosion grade after 6 and 12 h exfoliation corrosion is N, PC.

Abstract Hepatocellular carcinoma (HCC) is one of the most lethal tumor types worldwide. Glycosylation has shown promise in the study of tumor mechanisms and treatment. The glycosylation status of HCC and the underlying molecular mechanisms are still not fully elucidated. Using bioinformatic analysis we obtained a more comprehensive characterization of glycosylation of HCC. Our analysis presented that high glycosylation levels might correlate with tumor progression and poor prognosis. Subsequent Experiments identified key molecular mechanisms for ST6GALNAC4 promoting malignant progression by inducing abnormal glycosylation. We confirmed the contribution of ST6GALNAC4 to proliferation, migration, and invasion in vitro and in vivo. Mechanistic studies revealed that ST6GALNAC4 may be induced abnormal TGFBR2 glycosylation, resulting in the higher protein levels of TGFBR2 and TGF $$\beta$$ β pathway increased activation. Our study also provided a further understand of immunosuppressive function of ST6GALNAC4 through T antigen-galectin3+ TAMs axis. This study has provided one such possibility that galectin3 inhibitors might be an acceptable treatment choice for HCC patients with high T antigen expression.

Abstract Load can change the mechanical environment of dynamic and static stable structures of the shoulder joint, increase the risk of tissue damage and affect the stability of the shoulder joint, but its biomechanical mechanism is still unclear. Therefore, a finite element model of the shoulder joint was constructed to analyze the mechanical index changes of shoulder joint abduction under different loads. The stress of the articular side on the supraspinatus tendon was higher than that of the capsular side, with a maximum difference of 43% due to the increased load. For the deltoid muscle and glenohumeral ligaments, increases in stress and strain were obvious in the middle and posterior deltoid muscles and inferior glenohumeral ligaments. The above results indicate that load increases the stress difference between the articular side and the capsular side on the supraspinatus tendon and increases the mechanical indices of the middle and posterior deltoid muscles, as well as the inferior glenohumeral ligament. The increased stress and strain in these specific sites can lead to tissue injury and affect the stability of the shoulder joint.

ABSTRACTImproved strength-ductility synergy is not uncommon among metallic materials with gradient structures of grains and twins. In this work, we report that the texture gradient innately created in Al-Mn strips by twin-roll casting is also capable of increasing the material’s ductility without sacrificing its strength. Analyses based on crystal plasticity theory demonstrated that the underlying mechanism of this texture-gradient-induced ductility enhancement lies in the orientation-dependent slip and grain rotation, which generate backstress, alter the local stress triaxiality, and delay the fracture process. These results advocate the integration of texture gradient design into the fabrication of high-performance gradient materials.

Unlike the rod-like T–Al20Cu2Mn3 dispersoids, the spherical Al7(Cr, Mn) and Al6(Fe, Mn, Mo) precipitated in Al–Cu–Mg–Ag–Mn alloys with CrxMo(0.2-x) addition, retained the deformed substructure, and acted as a dispersion reinforcement. In this study, the precipitation behavior of dispersoids in Al–Cu–Mg–Ag–Mn alloys with various CrxMo(0.2-x) (x = 0.15, 0.10, 0.05 wt.%) at 400 °C/12 h + 515 °C/24 h homogenization was investigated. The compositional and structural evolution of dispersoids in Al–Cu–Mg–Ag–Mn alloys were investigated by optical microscopy and atomic resolution high-angle annular dark-field scanning transmission electron microscopy. The effects of CrxMo(0.2-x) addition on morphology, size and number density of dispersoids inhibited the recrystallization behavior and improved the mechanical properties of alloys in varying degrees. When x = 0.15 in CrxMo(0.2-x), the large amount of Al7(Cr, Mn) precipitates to refine the T–Al20Cu2Mn3, and dispersoid-free zones (DFZ) significantly decreases. As x decreases to 0.05, the homogeneous Al6(Fe, Mn, Mo) dispersoids present the opposite precipitation trend of T–Al20Cu2Mn3 to compensate for the DFZ. During the deformation and subsequent heat treatment, the Al–Cu–Mg–Ag–Mn alloy with Cr0.05Mo0.15 addition maintains the highest substructure and dislocation density owing to the highest number density of spherical dispersoids, demonstrating excellent mechanical properties at ambient and elevated temperatures.

Purpose – This paper aims to propose a medium-term forecast model for the daily passenger volume of High Speed Railway (HSR) systems to predict the daily the Origin-Destination (OD) daily volume for multiple consecutive days (e.g. 120 days). Design/methodology/approach – By analyzing the characteristics of the historical data on daily passenger volume of HSR systems, the date and holiday labels were designed with determined value ranges. In accordance to the autoregressive characteristics of the daily passenger volume of HSR, the Double Layer Parallel Wavelet Neural Network (DLP-WNN) model suitable for the medium-term (about 120 d) forecast of the daily passenger volume of HSR was established. The DLP-WNN model obtains the daily forecast result by weighed summation of the daily output values of the two subnets. Subnet 1 reflects the overall trend of daily passenger volumes in the recent period, and subnet 2 the daily fluctuation of the daily passenger volume to ensure the accuracy of medium-term forecast. Findings – According to the example application, in which the DLP-WNN model was used for the medium-term forecast of the daily passenger volumes for 120 days for typical O-D pairs at 4 different distances, the average absolute percentage error is 7%-12%, obviously lower than the results measured by the Back Propagation (BP) neural network, the ELM (extreme learning machine), the ELMAN neural network, the GRNN (generalized regression neural network) and the VMD-GA-BP. The DLP-WNN model was verified to be suitable for the medium-term forecast of the daily passenger volume of HSR. Originality/value – This study proposed a Double Layer Parallel structure forecast model for medium-term daily passenger volume (about 120 days) of HSR systems by using the date and holiday labels and Wavelet Neural Network. The predict results are important input data for supporting the line planning, scheduling and other decisions in operation and management in HSR systems.

Background Cage retropulsion after transforaminal lumbar interbody fusion (TLIF) is a common complication that is more frequently detected in the early postoperative period. Revision in the early stages is relatively less difficult in symptomatic cases. However, cage retropulsion is quite rare for patients with intervertebral osseous fusion in the long term after TLIF, and there are no relevant reports related to the revision plan. Case presentation Here, we report a case of a patient who underwent L4‐S1 TLIF at another hospital 4 years ago, accompanied by recurrent pain and discomfort of the left lower limb after the operation. Due to recent condition aggravation, it was considered to be caused by compression of the nerve root due to cage retropulsion. Nerve root sealing and endoscopy surgery were performed on the operative segment. It was found that cage retropulsion at the L4/5 level was a suspicious focus according to careful analysis of the clinical manifestations of the patient. Selective block of the nerve root on the level resulted in relief of the patient's original symptoms. After the posterior edge of the cage was exposed under the endoscope through an intervertebral foramen approach, the posterior edge of the cage protruding into the spinal canal was removed by high‐speed burr grinding, working casing reduction and other methods. Postoperative symptoms of pain in the low back and lower limb were relieved completely. Conclusions It is feasible to use the power system to remove the retrograde cage under the endoscope through the intervertebral foramen approach for the revision of symptomatic polyether ether ketone (PEEK) cage retropulsion in the long term after TLIF.

The objective of this study was to assess the impact of concentrated cottonseed protein (CPC) as a substitute for fishmeal (FM) in juvenile hybrid culter (Erythroculter ilishaeformis ♀ × Ancherythroculter nigrocauda ♂). A total of 360 fish with an initial body weight of 10.0 ± 0.5 g were randomly allocated into 12 indoor culture tanks, with each tank containing 30 fish. Four diets were formulated in which fish meal (FM) was replaced by CPC at different inclusion levels: 0% (T0), 15% (T15), 30% (T30), and 45% (T45). The corresponding amounts of CPC included were 0, 61, 122, and 182 g/kg, respectively. At the end of the 10-week feeding trial, the findings revealed an inverse correlation between the proportion of CPC replacing FM and both final body weight (FBW) and weight growth rate (WG) in hybrid culter. Specifically, the T30 and T45 groups exhibited significantly lower FBW and WG compared to the T0 group (p < 0.05). No significant differences in crude protein and ash contents were observed among all groups (p > 0.05). However, the crude lipid content was highest in hybrid culter fed the T45 diet and lowest in the T0 group (p < 0.05). There were no significant differences in muscle amino acid composition among all treatment groups (p > 0.05). The contents of total protein (TP) and albumin (ALB) declined slightly as the proportion of FM substituted by CPC increased, yet this decline did not reach statistical significance (p > 0.05). Serum alanine aminotransferase (ALT) activity elevated with increasing dietary CPC, and the T45 group exhibited significantly higher ALT activity compared to the T0 group (p < 0.05). The hepatic activities of superoxide dismutase (SOD) and catalase (CAT) were significantly lower in the T45 group than in the T0 and T15 groups (p < 0.05). Furthermore, there was a decrease in intestinal villi length with an increasing replacement ratio of FM by CPC, and the villi length in the T45 group exhibited a significant reduction when compared to that in the T0 group (p < 0.05). It is concluded that replacing 15% FM with CPC does not exert obviously detrimental effects on growth performance, serum biochemical indices, intestinal morphology, muscle amino acid profile, or antioxidant performance of juvenile hybrid culter.

This study investigates the monotonic and cyclic performance of composite bucket foundation breakwater in clay through centrifuge modeling. The application of monotonic loads simulates extreme wave conditions, and cyclic load corresponds to long-term serviceability conditions. In centrifuge tests, three typical soil strengths were tested, and two load eccentricities were simulated to check the influence of wave force height. Multiple measurements were conducted, including rotation angle, horizontal displacement, vertical settlement, and pore pressure variation. When soil strength increases in monotonic centrifuge tests, the ultimate bearing capacity of the bucket foundation experiences significant growth, and the foundation failure pattern varies. In responding to the monotonic test, the foundation’s rotation center constantly moved downward during the loading process, indicating that the deeper soil would be activated to resist the horizontal loading. In contrast, the rotation center movement in the symmetric centrifuge test was opposed to the non-symmetric test because the deeper soil was required to provide resistance to balance the more severe load under the non-symmetric loading condition. It should be noted that non-symmetric loading does not impact the bucket foundation as seriously as symmetric loading. The utilization of deep-soil resistance in non-symmetric tests is beneficial in controlling deformation.

In this paper, the microstructure and properties of Al–Mg–Mn alloy slabs with different thicknesses by twin-roll continuous casting were investigated. Under the twin-roll continuous casting process, the alloy melt conducts directional crystallization due to the near-horizontal heat transfer direction. In this way, the growth direction of the columnar crystal is changed to improve the shape and size of the sump and effectively eliminate the central segregation defect. Additionally, the improvement of segregation defects was more significant with the increase in thickness. As low angle grain boundary content and solution degree increased, the electrical conductivity decreased, the hardness increased, and the phenomenon of hard-soft-hard core-shell was significantly improved.

The effects of different cooling rates (0.3–66.2 K/s) on the solidification behavior, microstructural evolution, and mechanical properties of Al–Zn–Mg–Cu alloys during a short-flow process were investigated in detail. With the increasing cooling rate, the grain size first increased, then decreased, and finally, again increased, whereas the secondary dendrite arm spacing and the crystalline phase size were greatly reduced. Relatively high cooling rates (3.4–66.2 K/s) significantly increased elemental micro-segregation in α-Al due to the transition of the solidification mode from near-equilibrium to the Scheil mode. Moreover, the element trapping capacity at the end of solidification was enhanced at high cooling rates, especially for alloy D (66.2 K/s). Hence, the crystalline phase content first increased and then decreased at high cooling rates. During the short-flow process, the refinement of the crystalline phase and dendrites significantly promoted the re-dissolution of the crystalline phase and the elemental diffusion process, leading to improved mechanical properties. The yield strength, the tensile strength, and the elongation were improved from 420 MPa, 460 MPa, and 4.5% for alloy A to 457 MPa, 524 MPa, and 11.3% for alloy D, respectively.

Objective The injury of the annular ligament can change the stress distribution and affect the stability of the elbow joint, but its biomechanical mechanism is unclear. The present study investigated the biomechanical effects of different flexion angles of the annular ligament on elbow joint stability. Methods A cartilage and ligament model was constructed using SolidWorks software according to the magnetic resonance imaging results to simulate the annular ligament during normal, loosened, and ruptured conditions at different buckling angles (0°, 30°, 60°, 90°, and 120°). The fixed muscle strengths were 40 N (F1), 20 N (F2), 20 N (F3), 20 N (F4), and 20 N (F5) for the triceps, biceps, and brachial tendons and the base of the medial collateral ligament and lateral collateral ligament. The different elbow three‐dimensional (3D) finite element models were imported into ABAQUS software to calculate and analyze the load, contact area, contact stress, and stress of the medial collateral ligament of the olecranon cartilage. Results The results showed that the stress value of olecranon cartilage increased under different conditions (normal, loosened, and ruptured annular ligament) with elbow extension, and the maximum stress value of olecranon cartilage was 2.91 ± 0.24 MPa when the annular ligament was ruptured. The maximum contact area of olecranon cartilage was 254 mm2 with normal annular ligament when the elbow joint was flexed to 30°, while the maximum contact area of loosened and ruptured annular ligament was 283 and 312 mm2 at 60° of elbow flexion, and then decreased gradually. The maximum stress of the medial collateral ligament was 6.52 ± 0.23, 11.51 ± 0.78, and 18.74 ± 0.94 MPa under the different conditions, respectively. Conclusion When the annular ligament ruptures, it should be reconstructed as much as possible to avoid the elevation of stress on the surface of the medial collateral ligament of the elbow and the annular cartilage, which may cause clinical symptoms.

Abstract Background Common mental disorders are general term for mental disorders with high disability rates and significant social burden. The purpose of this study was to determine the degree of long-term disability associated with common mental disorders and to interpret the relationship between common mental disorders and long-term disability. Methods Participants in the 2013 China Mental Health Survey were followed up by telephone between April and June 2018. This study evaluated long-term disability over a five-year period using the World Health Organization’s Disability Assessment Schedule 2.0. Poisson regression was used to analyze the relationship between common mental disorders and long-term disability. Results A total of 6269 patients were followed up by telephone. In patients with common mental disorders, the prevalence of disability ranged from 7.62% to 43.94%. The long-term disabilities were significantly associated with dysthymic disorder (DD, RR:2.40; 95% CI:1.87-3.03), major depressive disorder (MDD, RR:1.63; 95% CI:1.34-1.98), generalized anxiety disorder (GAD, RR:1.95; 95% CI:1.15-3.09), obsessive-compulsive disorder (OCD, RR:1.68; 95% CI:1.24-2.22) and alcohol use disorder (AUD, RR: 1.42; 95% CI:0.99-1.96). Conclusions In China, common mental disorders raise the risk of long-term disability, and there is a critical need for monitoring patients with DD, MDD, GAD, OCD, and AUD. For improved quality of life and reduced disability levels, more resources need to be dedicated to mental health in the future.

High-throughput double cone specimens were used to study the influence of Mo on the microstructure evolution of Al–Cu–Mg–Ag alloy under a wide range of strain along the axis. The microstructure evolution was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and electron backscatter diffraction (EBSD). Results demonstrated that Al6(Fe, Mn, Mo) dispersoids formed in the Al–Cu–Mg–Ag alloy with the addition of 0.2% Mo during double-step homogenization. Meanwhile, rod-like Al20Cu2Mn3 and disk-like Al6(Fe, Mn, Mo) dispersoids segregated to opposite distribution in interdendritic regions and dendrite cores, respectively, which obviously eliminated the dispersoid-free zones and intragranular sparse regions. With different effective strains along the axis, Al6(Fe, Mn, Mo) dispersoids obviously reduced the transformation from Low-angle grain boundaries to High-angle grain boundaries. The nucleation and growth of dynamic recrystallization grains were effectively inhibited by the coupling of Al20Cu2Mn3 and Al6(Fe, Mn, Mo) dispersoids due to the obstruction of dislocation movement.

IntroductionThe impact of intergenerational caregiving on the mental health of providers remains a controversial topic, especially in countries like China where it is prevalent. Given the country’s aging population and recent liberalization of the two-child policy, understanding the effects of intergenerational caregiving on the mental health of middle-aged and older adult(s) individuals is crucial. This study aimed to explore the impact of intergenerational caregiving on mental health among middle-aged and older adult(s) individuals.MethodsWe analyzed data from the China Health and Aging Tracking Survey (CHARLS) 2013, consisting of 6602 participants finally. Personal information, family structure, financial support, health status, and physical measurements were selected for analysis. Correlation and regression analyses were used for relationships among variables controlling for potential confounding variables. Mental health status was evaluated using the depression self-rating scale.ResultsThere is a significant positive effect of intergenerational care on the mental health of middle-aged and older adult(s) people. Additionally, we re-profiled intergenerational care variables by considering the number and length of intergenerational caregivers, and found that the effects remained significant. Furthermore, the effects of intergenerational care vary across subgroups based on gender, age, nature of usual residence, marital status, and physical health status. Finally, we identified two mechanisms through which intergenerational caregiving positively affects mental health: intergenerational financial support and intergenerational spiritual support.DiscussionThese findings have important implications for policymakers, healthcare professionals, and family members in promoting the mental health of middle-aged and older adult(s) individuals in China.

Rotator cuff injuries account for 50% of shoulder disorders that can cause shoulder pain and reduced mobility. The occurrence of rotator cuff injury is related to the variation in shoulder load, but the mechanical changes in the rotator cuff caused by load remain unclear. Therefore, the mechanical results of the rotator cuff tissue during glenohumeral abduction and adduction were analyzed based on a finite element shoulder model under non-load (0 kg) and load (7.5 kg) conditions. The results showed that the maximum von Mises stress on the supraspinatus muscle was larger than that on the subscapularis, infraspinatus, and teres minor muscles during glenohumeral abduction. Compared with the non-load condition, the maximum von Mises stress on the supraspinatus muscle increased by 75% under the load condition at 30° abduction. Under the load condition, the supraspinatus joint side exhibited an average stress that was 32% greater than that observed on the bursal side. The von Mises stress on the infraspinatus muscle was higher than that in other rotator cuff tissues during adduction. The stress on the infraspinatus muscle increased by 36% in the load condition compared to the non-load condition at 30° adduction. In summary, the increased load changed the mechanical distribution of rotator cuff tissue and increased the stress differential between the joint aspect and the bursal aspect of the supraspinatus tendon.

The amygdala is a core region in the limbic system that is highly sensitive to stress. Astrocytes are key players in stress disorders such as anxiety and depression. However, the effects of stress on the morphology and function of amygdala astrocytes and its potential mechanisms remain largely unknown. Hence, we performed in vivo and in vitro experiments using a restraint stress (RS) rat model and stress-induced astrocyte culture, respectively. Our data show that norepinephrine (NE) content increased, cytotoxic edema occurred, and aquaporin-4 (AQP4) expression was up-regulated in the basolateral amygdala (BLA) obtained from RS rats. Additionally, the p38 mitogen-activated protein kinase (MAPK) pathway was also observed to be significantly activated in the BLA of rats subjected to RS. The administration of NE to in vitro astrocytes increased the AQP4 level and induced cell edema. Furthermore, p38 MAPK signaling was activated. The NE inhibitor alpha-methyl-p-tyrosine (AMPT) alleviated cytotoxic edema in astrocytes, inhibited AQP4 expression, and inactivated the p38 MAPK pathway in RS rats. Meanwhile, in the in vitro experiment, the p38 MAPK signaling inhibitor SB203580 reversed NE-induced cytotoxic edema and down-regulated the expression of AQP4 in astrocytes. Briefly, NE-induced activation of the p38 MAPK pathway mediated cytotoxic edema in BLA astrocytes from RS rats. Thus, our data provide novel evidence that NE-induced p38 MAPK pathway activation may be one of the mechanisms leading to cytotoxic edema in BLA under stress conditions, which also could enable the development of an effective therapeutic strategy against cytotoxic edema in BLA under stress and provide new ideas for the treatment of neuropsychiatric diseases.

Al–Zn–Mg–Cu alloys were fabricated with water-cooled copper casting. The microstructure of the alloys was characterized by electron probe microanalysis (EPMA), scanning electron microscope (SEM), transmission electron microscopy (TEM), and X-ray diffractometry (XRD). The mechanical properties were studied with by tensile and hardness tests. The results showed an enhanced effect of solid solution strengthening and precipitation strengthening with increased Cu content. The distribution spacing of the grain boundary precipitates (GBPs) increased, but the width of the precipitate-free zone (PFZ) decreased. The process enhanced the strength and plasticity of the alloy. The impact of precipitation strengthening decreased and the grain size and width of the PFZ decreased as the Zn/Mg ratio increased. Thus, the strength of the alloy decreased and its plasticity increased with increasing Zn/Mg ratios.

This study was undertaken to investigate the effect of low cast-rolling speeds (

In this paper, the formation mechanism of the vortex zone at different low cast-rolling speed was investigated elaborately with the aid of simulating flow field in cast-rolling zone. Additionally, the Influence of vortex effect on the central segregation defects of horizontal twin-roll casting (TRC) Al–Mg–Mn–Zn–Cu–Cr alloy sheet was analyzed in detail. The concrete results revealed that the area of the vortex zone shows an upward trend with decreasing cast-rolling speed, whereas the grain aspect ratio in the central area exhibits the reduction trend. The macro-segregation ratio of different elements at the vertex of the curve were also diminished when the cast-rolling speed decreases, due to the vortex effect can improve the nucleation rate and uniform the temperature field. More importantly, the presence of obvious valleys on both sides of the macro-segregation ratio curve, which fully proves the existence of vortex zones in the cast-rolling zone of the D2 and D3 cast-rolled sheets. Moreover, the values, uniformity and consistency of the hardness were significantly improved, mainly result from the vortex effect which enhances solid solubility of the alloy and improves the microstructural uniformity of sheet. While, the intensities of the shear textures and rolling texture of the cast-rolled sheet was notably enhanced with the gradual reduction of cast-rolling speed. Ultimately, the high alloying Al–Mg–Mn–Zn–Cu–Cr alloy cast-rolled sheet with excellent comprehensive properties was obtained.

ObjectivesAssess the validity of the Chinese version of the Dominic Interactive (DI), a 91-item, video-based diagnostic screening instrument for children that assesses four internalized disorders (phobias, separation anxiety disorder, generalized anxiety disorder, and major depressive disorder) and three externalized disorders (attention-deficit/hyperactivity disorder, conduct disorder, oppositional defiant disorder).Methods(1) Compare DI-generated “probable” or “possible” diagnoses to diagnoses based on the Development and Well-Being Assessment (DAWBA) instrument in 113 psychiatric outpatients and 20 community controls. (2) Administer DI to 1,479 children from elementary schools in Tianjin.ResultsIn the validation sample, DI with DAWBA concordance was much greater for internalized disorders (mean Kappa = 0.56) than for externalized disorders (mean kappa = 0.11). The positive predictive value of DI diagnoses ranged from 0.96 (generalized anxiety disorder) to 25% (oppositional defiant disorder) and negative from 0.81 to 0.96. Using “probable” cuts provides better results. In the survey, prevalence of probable DI disorders ranged from 1.0% (conduct disorder) to 13.1% (phobias). Internal consistency of all DI items was excellent (Cronbach alpha = 0.93) and that of the seven subscales ranged from 0.64 (phobias) to 0.87 (major depressive disorder). In multilevel SEM analyses, SRMR (Standardized root mean square residual) or each of the seven diagnoses was below 0.08 and each coefficient of determination was below 0.60.ConclusionThe Chinese DI is a convenient method of screening common mental disorders in Chinese children mainly for internalized disorders, which are the most prevalent diagnoses in that population. However its high negative predictive values for externalized could be used for screening.

In this study, a Ti/Al/Cu three-layer clad sheet was fabricated using horizontal twin-roll casting (HTRC) technology. The interfacial morphology, interfacial microstructure and phases, interfacial bonding strength, micro-hardness, and tensile properties of the clad sheet under different annealing and cold rolling conditions were investigated. The surface morphology of the titanium, copper and aluminum sheets after peeling was observed. Compared with the traditional compounding process, the cast-rolling bonding process can realize the direct combination of molten metal and solid metal strip and achieve higher bonding strength. In the as-cast sheet, the thickness of the diffusion layer is 3.6 μm and the average peel strength (APS) is 20.2 N/mm at the Ti/Al interface, meanwhile the values at the Cu/Al interface are 3.2 μm and 13.8 N/mm. Before the formation of intermetallic compound (IMC) at the interface, increasing annealing temperature can improve the bonding strength by promoting atomic interdiffusion. Further cold rolling can also improve the bonding strength by forming a wavelike interface. Under the action of huge rolling force, the matrices that were not well bonded in the cast-rolling process are contacted at the atomic scale, and as a result new bonding regions are created. By improving the interfacial bonding strength, appropriate annealing and cold rolling processes make the deformation of clad sheet more cooperative. According to the results obtained in this study, the best subsequent processing technology for Ti/Al/Cu clad sheet fabricated by HTRC is annealing at 300 °C for 1.5 h followed by a single pass cold rolling with 40% reduction.

A large number of dislocations and dislocation tangles are induced in the Al–Li alloy after 5% pre-stretching deformation before aging treatment, which increases the density of the defects in α(Al) matrix and affects the competitive precipitation relationship and precipitation behavior of δ′ (Al3Li), S′ (Al2CuMg) and T1 (Al2CuLi) precipitates during the aging process. The increase of crystal defects such as dislocations provides superior nucleation sites for the heterogeneous nucleation and promotes the precipitation of T1 phase, greatly improving the mechanical properties of the alloy. The uniform and dense precipitation of T1 phase in the grain reduces the potential difference between the grains and the grain boundaries. Therefore, not only does it reduce the driving force of intergranular corrosion (IGC), but also decreases the difference of the corrosion rate between the grain boundary and intragranular. These are beneficial to slow down the corrosion process and promote uniform corrosion. The intermittently distributed grain boundary precipitates (GBPs) in the T8 treated alloy cut off the continuous corrosion channel at grain boundaries and hinder the IGC process. Furthermore, the width of the precipitation free zones (PFZs) in the T8 treated alloy is narrow. Hence, the alloy exhibits excellent IGC resistance and superior corrosion protection performance under T8 single aging treatment. The pre-aging process in low temperature before T8 single aging treatment greatly enhances the precipitation driving force of T1 phase and effectively promotes the precipitation of T1 phase in the subsequent high-temperature aging process, which further increases the strength and improves the IGC resistance of the alloy.

With the rapid development of e-commerce and the dramatic upsurge in direct-to-consumer deliveries, the last-mile problem has become increasingly apparent. With the distinct advantages of bringing economies of scale and providing 24/7 contactless self-service, smart parcel lockers play a critical role in solving the last-mile problem. However, due to a lack of planning, myopia expansion, and an ambiguous profit model, smart parcel locker suppliers in China have been suffering huge economic losses, restricting their further development. In the study, on the basis of an in-depth analysis of the cost elements and major revenue sources of smart parcel lockers, we propose a bilevel programming model to optimize the location of community smart parcel lockers with the upper-level model maximizing the profit of a third-party smart parcel locker supplier and the lower-level model maximizing user satisfaction. Then, a solution algorithm based on the genetic algorithm is proposed. Finally, some numerical experiments are carried out based on a medium-scale residential community in Jiading District, Shanghai. The sensitivity analyses conducted in this study reveal how the user satisfaction evaluation and the investment budget influence the expected profit. The modelling framework and numerical results can provide third-party smart parcel locker suppliers with significant theoretical support and practical guidance on planning the investment budget and optimizing the smart parcel locker locations to maximize their profit.

In this study, a vertical twin-roll cast (TRC) thermal-fluid coupling model was established to determine a suitable roll-casting velocity. A slab of 0.9 mm thick roll-cast Al-50 wt.% Si alloy with a two-phase zone width of 473 °C was prepared at a velocity of 20 m/min for the first time. In addition, the finite element simulation showed that the average heat transfer rate had a positive correlation with the roll-casting velocity. When the roll-casting velocity increased to 20 m/min, the average heat transfer rate reached 1260 K/s, at which point, the average size of the primary Si was merely 16.5 μm. This was a decrease of approximately 90% when compared with the size of alloys cast with conventional methods. After carrying out semi-solid heating, an observation on the distribution of alloy elements identified a novel phenomenon of solute redistribution, i.e., inverse segregation. This inverse segregation process was highly significant in further controlling solute redistribution in the alloy. Additionally, it provided a new concept for improving roll-cast segregation.

In this work, the wear behaviors of a 2060 Al-Li alloy prepared by the twin-roll casting (TRC) process was analyzed and supplemented with coupling simulation calculations. As the load increased from 2 N, 5 N, 10 N, and 20 N at room temperature, the friction coefficient decreased due to the oxidation lubrication triggered by heat accumulation, which was calculated via the simulation; the wear volume decreased; and the decrease in wear volume rise rate was a result of dynamic recrystallization and grain rotation. Observing the grain rotation and analyzing the texture evolution law during wear tests with scanning electron microscopy (SEM) and electron back-scattered diffraction (EBSD) was an innovation. To support the rotation behavior, a method for calculating the Schmid factor of rotating grains was developed. As the load rose, the R-Cube {001} 〈110〉 texture rotated to the rotating cube {001} 〈310〉 texture towards the α-fiber line. The modification decreased the maximum Schmid factor along the sliding and rolling directions, indicating an increase in initial strength and wear resistance. In addition, at a 2 N load, the TRC-3 sample with higher substructure and deformation texture exhibited less wear volume than the TRC-6 sample.

Insecticides harm the beneficial organisms, such as predatory spiders, through direct killing or regulation of the development and reproduction. In this study, the bioassay showed that the treatment of juvenile hormone (JH) analogue fenoxycarb delayed the moulting of Pardosa pseudoannulata, a dominant predatory spider in paddy fields. In order to figure out the regulatory mechanism of fenoxycarb on the spider development, we systematically analyzed JH biosynthesis in P. pseudoannulata. All genes involved in JH biosynthesis pathway were retrieved from the genome of P. pseudoannulata, except for CYP15A1. The absence of CYP15A1 was in agreement with the identification of methyl farnesoate (MF) rather than JH III in the spider. The delayed moulting and decreased expression of JH biosynthesis-related genes in the MF-applied spiderlings supported that MF was an active JH. Fenoxycarb treatment significantly upregulated the transcriptional level of JH biosynthesis-related genes and consequently delayed the spiderling moulting. In the spider development, ecdysteroid played the opposite role, in contrast to MF, to accelerate the development, as our previous study. Here we found that the treatment of ecdysteroid analogue tebufenozide accelerated P. pseudoannulata spiderling moulting, which resulted from the expressional suppression of ecdysteroid biosynthesis-related genes. In total, the JH and ecdysteroid analogues affected the development of P. pseudoannulata by the expressional regulation of biosynthesis-related genes, which would be helpful for the evaluation of hormone analogue insecticides in environmental safety, and useful for the protection and application of P. pseudoannulate and related spider species.

7055 aluminum alloy was produced by twin-roll casting (TRC) and by conventional mold casting (MC). Homogenization at 465 °C for 24 h with natural cooling was applied, followed by uniaxial hot compression tests to verify the hot workability of the alloy. The results show that the TRC sample possessed a lower intermetallics fraction with a smaller size but much larger grain size than the MC sample in both the as-cast and as-homogenized microstructures. In the post-homogenization cooling stage, precipitation of T phase (AlZnMgCu) occurred, Al3Zr acted as nucleation sites for the precipitation of T phase. T phase precipitation-free zone (PFZ) formed at the dendrite arm regions, the formation of the T phase PFZ was based on the Ostwald ripening mechanism. During hot compression test, the MC samples exhibited overall higher flow stress levels than those of TRC samples since the combination of the stronger grain refined strengthening and particle strengthening effects in the MC sample than those in the TRC sample. Macrocracks were developed in the MC sample during hot compression, the source of which was the coarse intermetallic particles in the microstructures. No macrocrack was formed in the TRC sample under the same compression conditions owing to its much finer initial intermetallics, lower accumulation of substructures and local stress.

BackgroundAlthough evidence-based and effective treatments are available for people with major depressive disorder (MDD), a substantial number do not seek or receive help. Therefore, this study aimed to (1) investigate the total help-seeking rate and first-time help-seeking choices; (2) explore the perceived helpfulness of 23 potential sources; and (3) evaluate the factors related to help-seeking behaviors among patients with MDD.Materials and MethodsData came from the Tianjin Mental Health Survey (TJMHS), which included a representative sample of adult community residents (n = 11,748) in the Chinese municipality of Tianjin. Of these, 439 individuals were diagnosed with lifetime MDD according to the Diagnostic and Statistical Manual-fourth edition (DSM-IV) and administered a help-seeking questionnaire.ResultsIn a survey, 28.2% of patients with MDD living community reported that they had ever sought any help during their entire lifetime before the interview, with 8.2% seeking help in mental healthcare settings, 8.0% only in other healthcare settings, and 12.0% only in non-healthcare sources (e.g., family, friends, and spiritual advisor). Among help-seekers, the first help mainly was sought in non-healthcare sources (61.3%), followed by healthcare settings (25.8%) and mental healthcare settings (12.9%). The majority of MDD individuals thought the non-healthcare sources were not helpful and mental healthcare settings were helpful or possibly helpful to solve mental problems. Female, having 10–12 or higher education years, comorbid anxiety disorders were associated with increased help-seeking.ConclusionA small percentage of individuals with MDD living in community of Tianjin sought help. They preferred non-healthcare sources to healthcare settings. Demographic and clinical features were associated with help-seeking behaviors.

There are many options for passengers choosing to travel by train. In order to maximize price revenue requests, railway companies must consider the differences between passenger types in the process of formulating ticket strategies. This study firstly subdivides passenger demand according to the latent class model based on Stated Preference (SP) and Revealed Preference (RP) survey data, then the passenger’s preference for train service attributes is identified. Based on the prospect theory, logit model and passenger flow transfer model, the final passenger flow assignment result is obtained. A differential pricing and seat allocation model aiming at maximizing price revenue is established, and a simulated annealing (SA) algorithm is designed to solve it. The results of the case show that the proposed model can increase revenue by 3.52% and by 1.02% compared with the result under single fares and without demand division.

Abstract Background Little is known about the public stigma on mental illness and mental health knowledge (MHK) in China, public stigma and low MHK can negatively affect patients’ health and increase the burden of mental disorders on society. This study aimed at investigating the rates of stigma and MHK, the correlates of stigma and MHK, and the association between MHK and stigma among a Chinese population. Methods The data is from the Tianjin Mental Health Survey (TJMHS), which involved a large and a representative sample of adult community residents in the Chinese municipality of Tianjin (n = 11,748). In a 12% random subsample (n = 1775) the Perceived Discrimination and Devaluation scale (PDD) and a Mental Health Knowledge Questionnaire (MHKQ) were administered. First, percentages of the responses to the individual items of the PDD and MHKQ were investigated. Second, sociodemographic correlates of PDD and MHK, and the association between stigma and MHK were investigated. Results We found that a sizable proportion of participants responded that others would hold a negative attitude towards (former) mental patients, especially with regard to engaging in closer personal relationships. Most people were not familiar about the causes, treatments and prevention of mental illness. Resident area, age, education level, Per capita family income and employment status were related to devaluation score and MHKQ score. MHK was negatively associated with public stigma. Conclusions There is room for improvement with regard to levels of public stigma and MHK in China. Providing psychoeducation to improve public MHK could also contribute to reduction of public stigma.

As a new non-traditional method of alloy preparation, the electromagnetic twin-roll casting (ETRC) technology overcomes the defects of traditional technologies in the preparation of traditional aluminum alloy, especially Al–Li alloy, such as gas hole in the traditional mold casting and macro segregation in the twin-roll casting (TRC) process, which greatly improves the comprehensive properties of the alloy strip. In present work, the evolution of microstructure and properties of Al–Li alloy fabricated by copper mold casting, and TRC and ETRC processes during homogenization have been investigated in detail. Under the action of electromagnetic field, the secondary dendrite arm spacing (SDAS) of the alloy reduces significantly and the solidification structure of the alloy refines dramatically. Moreover, the volume fraction of non-equilibrium eutectic phases and intermetallics which continuously distributes in the interdendritic region and grain boundaries decreases remarkably, and the dendritic network as well as the microsegregation of the alloying elements eliminates effectively. Therefore, compared with the traditional technologies, the homogenization time of the alloy fabricated by ETRC is greatly shortened, which provides a new idea for the short process and efficient preparation of Al–Li alloy.

Background: Anxiety disorders (ADs) are a group of disorders with a high disability rate and bring a huge social burden. In China, information on future trends in the disability among community ADs patients and its determinants are rare. The objectives of this study are to describe the future trends in the disability among ADs patients living in community and to investigate the determinants of the disability.Methods: Participants diagnosed with 12-month ADs in the China Mental Health Survey (CMHS) were followed up by telephone from April to June 2018 to assess the future trends in the disability in a 5-year interval using the World Health Organization's Disability Assessment Schedule 2.0. The disability rate was reported and its determinants were analyzed by complex sample design multivariate logistic regression.Results: Totally 271 patients were interviewed by telephone and 33 informants finished proxy interviews. The disability rates were 45.9% and 14.3% among ADs patients at baseline and during the follow-up. Patients with general anxiety disorder (GAD) or agoraphobia with/without panic disorder (AGP) had the lower decrease and higher disability during the follow-up than patients with other subtypes. Patients aged in middle age (aged 40–49 years old, OR = 11.12, 95% CI: 4.16–29.72), having disability at baseline (OR = 7.18, 95% CI: 1.37–37.73), having comorbidity with three or more physical diseases (OR = 9.27, 95% CI: 2.48–34.71), and having comorbidity with other mental disorders (OR = 3.97, 95% CI: 1.13–13.96) had higher disability during the follow-up.Conclusions: The disability rate tends to decrease among ADs patients living in communities. Treatment priority should be given for ADs patients with disability and those in middle age. Treatments for the comorbidity of other mental disorders or physical diseases should be considered when treating anxiety.

Abstract Background Failure to seek treatment for mental health disorders is a serious public health concern. Unfortunately, there is little insight into help-seeking and its associated factors in China which has undergone rapid economic development in the past 30 years and has an increasing prevalence of mental disorder. Therefore, this study aimed to (1) investigate help-seeking rates in healthcare and non-healthcare settings and (2) investigate the correlates of help-seeking behavior in a large Chinese survey. Methods Data came from the Tianjin Mental Health Survey (TJMHS), a representative sample of adult community residents in the Chinese municipality of Tianjin (n = 11,748). Of these, 1759 individuals had ≥1 axis-I diagnosis according to the Diagnostic and Statistical manual– fourth edition (DSM-IV) and were administered a Help-Seeking Questionnaire. Results 15.7% of patients reported that they had ever sought help during their entire lifetime before the interview, with 4.5% seeking help in mental healthcare, 3.2% in other healthcare and 8.1% in non-healthcare settings (e.g., family, friends, and spiritual advisor). Among help-seekers, the first help was mostly sought in non-healthcare settings (58.4%), followed by healthcare (27.5%) and mental healthcare settings (24.5%). Female gender, younger age, having 7–9 years vs 0–6 years of education, a low income, a psychotic disorder and having ≥2 disorders were associated with increased help-seeking. Older age, being married and having a psychotic or organic disorder were associated with increased help-seeking in healthcare vs. non-healthcare settings. Conclusion A small percentage of persons with mental disorders in the Tianjin region seek help and among those who do, variations in the types of help-seeking may be partially explained by demographic and clinical characteristics.

Plants play an essential role in methane (CH4) production, transport and release processes of constructed wetlands but as yet there has been no consistent and clear consensus of their impacts on CH4 emissions. In this study, we used plant presence, species richness, plant species-specificity, and harvesting activity information obtained by reviewing papers published from 1993 to 2018 to elucidate the key factors that drive CH4 emission from constructed wetlands. Although it was not statistically significant, plant presence increased the CH4 emissions compared to unvegetated conditions and relatively lower values were observed for constructed wetlands planted with Acorus calamus, Cyperus papyrus or Juncus effusus. The use of a single plant species not only changed the production and consumption of CH4 by affecting the functioning of roots but also influenced the process of CH4 entering the atmosphere under different transport capacities. The CH4 flux reached 1.0686 g CH4 m−2 d−1 from the Zizania latifolia system, which is eight times larger than that of the Phalaris arundinacea system. The mixed systems exhibited a positive increase in CH4 flux with plant species richness due to the complementary effects of the root exudates excreted from different plants. The minimum CH4 value (−0.0084 g CH4 m−2 d−1) was observed in the three-species system (Oenanthe javanica, Phalaris arundinacea and J. effusus). These results demonstrate that selecting several species with lower methane fluxes such as Typha latifolia and C. papyrus and suitably regulating harvesting in constructed wetlands can be more effective for mitigating the potential of CH4 emissions while maintaining the efficiency of sewage purification.

Climate warming would be generally influenced by the quantity and component of greenhouse gases during the carbon and nitrogen removal in constructed wetlands (CWs). In this study, the impacts of the combinations by walnut shell (organic-rich substrate improving denitrification), manganese (Mn) ore (electron-exchange substrate transferring CH4 to CO2) and activated alumina (phosphorus-adsorption substrate) on global warming potentials (GWPs) were investigated to propose a strategy for both mitigating GWPs and performing well in wastewater treatment. During hybrid CWs, the highest COD and TP removal efficiencies were respectively 89.4% and 98.1% in CWs with the substrate combination of Mn ore and activated alumina, and the highest TN removal efficiency was in CWs with walnut shell and Mn ore. The substrate combination of walnut shell and Mn ore would simultaneously strengthen the nitrification and denitrification process resulting in the lowest N2O flux in CWs. The combinations of Mn ore with walnut shell or activated alumina could significantly decrease the GWPs through promoting the conversion of CH4 to CO2 due to the better redox potential environment favorable for methanotrophs (pmoA) instead of methanogenesis (mcrA) provided by Mn ore. This study provided a feasible way to mitigate climate warming during wastewater treatment in CWs by using substrate combination of Mn ore and walnut shell.

Herein, the effects of Si content on the microstructure evolution of Al-Mg-Si alloys during twin-roll casting (TRC) and subsequent heat treatment were characterized using scanning electron microscopy, emission electron probe micro analysis, electron backscatter diffraction, and transmission electron microscopy. The effects of insoluble Si particles, solute gradient, and recrystallization on the mechanical properties of the alloy in the T4P state were analyzed. An inhomogeneous deformation in the thickness direction of the TRC strip was observed during the pre-strain test. A premature local deformation at the element barren region (EBR) in the middle of the strip was considered to be the origin of the limited mechanical properties. By increasing the Si from 0.7 wt% to 1.1 wt%, the content and uniformity of the solute in the EBR can be effectively improved. The stronger work-hardening ability weakens the inhomogeneous deformation. Si addition significantly increased the number of insoluble Si particles during the heat treatment. The structure with a hard shell and soft core in the TRC strip significantly reduced the negative effect of insoluble Si particles on the mechanical properties. The tensile strength and uniform elongation of the strip increased from 159.44 MPa and 18.36% to 209.96 MPa and 29.791%, respectively.

In this study, we examined ticket pricing and train stop planning for the high-speed railway (HSR), which integrates two key aspects of railway operation and organization. We considered that passenger demand is sensitive to the generalized travel cost (depending on the ticket price and the travel time) and that the train stop plan can affect the travel time and passenger distribution. Then, a mixed-integer non-linear optimization model was proposed for the joint problem of ticket pricing and train stop planning to maximize HSR’s transport revenue and minimize passengers’ travel time. Based on the high similarity between combinatorial optimization problems and the solid annealing principle, we designed a combined simulated annealing (CSA) algorithm to solve practical problems. The results of a numerical example in the real HSR network showed that the proposed method can improve transport revenue by 5.1% and reduce passengers’ travel time loss by 11.15% without increasing transport capacity.