1. The potential clinical value of platelet aggregation in colorectal tumor progression
- Author
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Yuyu Chen, Guanghua Liu, Jialong Yuan, Ju Zuo, Huan Liu, and Hao Liu
- Subjects
Tumor cell-induced platelet aggregation ,Colorectal tumors ,Progression ,Clinical value ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Objective The present study is to examine whether platelet aggregation function, platelet count and mean platelet volume are indicators that related to clinicopathological characteristics of colorectal cancer. Methods A total of 546 patients with colorectal tumors and 118 healthy controls were enrolled, and patients with colorectal tumors were grouped according to malignancy, prognosis, recurrence and metastasis. The parameters of platelet aggregation function included max aggregation ratio, average aggregation ratio and max aggregation time were detected. 546 patients were induced by arachidonic acid, meanwhile, 415 of which were additionally induced by adenosine diphosphate. Of 118 healthy controls, 60 cases were induced by arachidonic acid and 58 cases were induced by adenosine diphosphate. We evaluated the intergroup significance of these indexes by receiver operating characteristic analysis. Results The levels of max aggregation ratio, average aggregation ratio and platelet count were related to progression including cancerization, radical operation and recurrence and metastasis (P
- Published
- 2024
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