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Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors and various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case of severe thrombocytopenia during intensive care unit (ICU) hospitalization that was likely to be associated with vancomycin. By revealing the process of identifying this case of DITP and reviewing relevant clinical studies, a risk alert of vancomycin-related severe hematotoxicity should be considered.

ObjectiveTo explore the role of pharmacists and innovation of pharmacy interventions for COVID-19 patients in China.MethodsWe comprehensively searched PubMed and Chinese databases Sinomed, China National Knowledge Infrastructure to identify articles reporting pharmacist interventions and pharmacy services for COVID-19 patients using a predefined search strategy. The search period was from inception to April 7th 2020. We also manually searched the reference list of included articles and websites of important journals with special issues for COVID-19.ResultsA total of 156 articles were identified by applying the search criteria. After screening, 91 articles, with the majority are literature reviews (n = 77, 84.62%) published in Chinese (n = 83, 91.2%), were included. Pharmacist interventions for COVID-19 patients most commonly related to guidelines or consensus development for the treatment of disease and practice procedure to prevent the spread of COVID-19 (n = 10, 10.98%), the supply of medicines to treat patients with severe respiratory or systematic symptoms related to COVID-19 (n = 10, 10.98%), formulating infections prevention and control strategies related to COVID-19 for pharmaceutical personnel/pharmacy staff (n = 14, 15.39%), new way of delivery pharmacy services and the implementation of new pharmacy services for COVID-19 outbreak (n = 14, 15.39%), routine pharmacy services under the restrict limit of COVID-19 outbreak (n = 39, 42.86%), and case series analysis of treatment regimens using existing, routinely collected data (n = 4, 4.40%).ConclusionPharmacy services have a role in the COVID-19 pandemic control, and there were many rapid changes in response to the pandemic.

Cu2O rhombic dodecahedra were used to photocatalyze thiobenzamide cyclization in tetrahydrofuran (THF) forming 3,5-diphenyl-1,2,4-thiadiazole under 390 nm light illumination. The rhombic dodecahedra outperform cubic and octahedral Cu2O crystals. They can also photocatalyze thiobenzamides bearing a wide range of substituent groups with generally high product yields in 18 h at room temperature. Electron, hole and various radical scavenging experiments were performed to support the proposed reaction mechanism. This work demonstrates again that the use of surface-controlled metal oxide crystals offers huge cost advantages over the covalent organic framework (COF) photocatalysts for some organic transformations. [ABSTRACT FROM AUTHOR]