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210 results on '"Guan, Xinyuan"'

12. Abstract 4452: FASN inhibition overcomes immune evasion by upregulating MHC-I in hepatocellular carcinoma

Author

Huang, Jiao, primary, Tsang, Wai Ying, additional, Fang, Xiaona, additional, Zhang, Yu, additional, Luo, Jie, additional, Gong, Lanqi, additional, Zhang, Baifeng, additional, Wong, Ching Ngar, additional, Liu, Beilei, additional, Huang, Jinlin, additional, Yang, Yuma, additional, Liu, Shan, additional, Li, Zhihong, additional, and Guan, Xinyuan, additional

Published
2023
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15. Abstract 4450: SOX4 promotes tumor development and immune evasion via disruption of zinc homeostasis between nasopharyngeal carcinoma cells and T cells

Author

Yang, Yuma, primary, Gong, Lanqi, additional, Luo, Jie, additional, Fang, Xiaona, additional, Huang, Jiao, additional, Bai, Lu, additional, Liu, Qin, additional, Liu, Beilei, additional, Liu, Shan, additional, Huang, Jinlin, additional, Wong, Ching Ngar, additional, Zhang, Baifeng, additional, Zheng, Danyang, additional, Zhang, Yu, additional, Dai, Wei, additional, and Guan, Xinyuan, additional

Published
2023
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18. Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition the Hippo signaling pathway in human bladder cancer

Author

Lyu Zhaojie, Liu Yuchen, Chen Miao, Chen Yacun, Wu Shayi, He Anbang, Liao Xinhui, Zhang Meng, Wu Peipei, Mei Hongbing, Wang Feng, Cai Zhiming, and Guan Xinyuan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Transitional cell carcinoma (TCC) of the bladder, the major histologic subtype of bladder cancer, is increasing in incidence and mortality, which requires the identification of effective biomarkers. Actin-regulating proteins have recently been proposed as important antitumor druggable targets. As a gelsolin-family actin-modulating protein, CAPG (gelsolin-like actin-capping protein) generated great interest due to its crucial effects in various biological and physiological processes; however, the role and mechanism of CAPG in TCCs remain unknown. Materials and methods: Bioinformatic analysis and immunohistochemistry of clinical specimens were performed to detect the expression level of CAPG. Both in vitro and in vivo assays were used to determine the oncogenic effect of CAPG in TCCs. Male 4–5-week-old BALB/c nude mice were used for in vivo tumorigenesis assays, while SCID mice were used for in vivo metastatic assays. Affymetrix microarray was used to identify the underlying molecular mechanism. Western blot and immunofluorescence were used to validate the expression and localization of proteins. Results: CAPG was frequently upregulated in TCCs and associated with clinical aggressiveness and worse prognosis. Functional assays demonstrated that CAPG could contribute to the tumorigenesis, metastasis and epithelial-mesenchymal transition (EMT) of TCCs both in vitro and in vivo . A novel mechanism that CAPG promoted TCC development via inactivating the Hippo pathway, leading to a nucleus translocation of Yes-associated protein was suggested. Conclusions: The current study identified CAPG as a novel and critical oncogene in TCCs, supporting the pursuit of CAPG as a potential target for TCC intervention.

Published
2019
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23. Single‐Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma

Author

Jia, Yongxu, primary, Zhang, Baifeng, additional, Zhang, Chunyang, additional, Kwong, Dora Lai‐Wan, additional, Chang, Zhiwei, additional, Li, Shanshan, additional, Wang, Zehua, additional, Han, Huiqiong, additional, Li, Jing, additional, Zhong, Yali, additional, Sui, Xin, additional, Fu, Li, additional, Guan, Xinyuan, additional, and Qin, Yanru, additional

Published
2023
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24. S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos

Author

Wang, Xia, primary, Huang, Hongyang, additional, Sze, Karen Man-Fong, additional, Wang, Jin, additional, Tian, Lu, additional, Lu, Jingyi, additional, Tsui, Yu-Man, additional, Ma, Hoi Tang, additional, Lee, Eva, additional, Chen, Ao, additional, Lee, Joyce, additional, Wang, Ying, additional, Yam, Judy Wai Ping, additional, Cheung, Tan-To, additional, Guan, Xinyuan, additional, and Ng, Irene Oi-Lin, additional

Published
2023
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29. Characterization of 26 deletion CNVs reveals the frequent occurrence of micro-mutations within the breakpoint-flanking regions and frequent repair of double-strand breaks by templated insertions derived from remote genomic regions

Author

Wang, Ye, Su, Peiqiang, Hu, Bin, Zhu, Wenjuan, Li, Qibin, Yuan, Ping, Li, Jiangchao, Guan, Xinyuan, Li, Fucheng, Jing, Xiangyi, Li, Ru, Zhang, Yongling, Férec, Claude, Cooper, David N., Wang, Jun, Huang, Dongsheng, Chen, Jian-Min, and Wang, Yiming

Published
2015
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37. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript

Author

Zheng, Yinli, primary, Wu, Jinjun, additional, Deng, Ru, additional, Lin, Censhan, additional, Huang, Yuhua, additional, Yang, Xia, additional, Wang, Chunhua, additional, Yang, Mingming, additional, He, Yangfan, additional, Lu, Jiabin, additional, Su, Xiaodong, additional, Yan, Qian, additional, Zhu, Yinghui, additional, Guan, Xinyuan, additional, Li, Yan, additional, and Yun, Jingping, additional

Published
2021
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39. Genomic instability in laminopathy-based premature aging

Author

Liu, Baohua, Wang, Jianming, Chan, Kui Ming, Tjia, Wai Mui, Deng, Wen, Guan, Xinyuan, Huang, Jian-dong, Li, Kai Man, Chau, Pui Yin, Chen, David J, Pei, Duanqing, Pendas, Alberto M, Cadiñanos, Juan, López-Otín, Carlos, Tse, Hung Fat, Hutchison, Chris, Chen, Junjie, Cao, Yihai, Cheah, Kathryn S E, Tryggvason, Karl, and Zhou, Zhongjun

Published
2005
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40. Correction: Hu, W., et al. Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype. Cancers 2020, 12, 2436

Author

Hu, Wen, primary, Zhang, Li, additional, Ferri-Borgogno, Sammy, additional, Kwan, Suet-Ying, additional, Lewis, Kelsey E., additional, Cun, Han T., additional, Yeung, Tsz-Lun, additional, Soliman, Pamela T., additional, Tarapore, Rohinton S., additional, Allen, Joshua E., additional, Guan, Xinyuan, additional, Lu, Karen H., additional, Mok, Samuel C., additional, and Au-Yeung, Chi-Lam, additional

Published
2021
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41. Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway

Author

Jin, Yuan, primary, Meng, Qilin, additional, Zhang, Bihui, additional, Xie, Chen, additional, Chen, Xue, additional, Tian, Baoqing, additional, Wang, Jiakang, additional, Shih, Tsung-Chieh, additional, Zhang, Yibo, additional, Cao, Jieqiong, additional, Yang, Yiqi, additional, Chen, Size, additional, Guan, Xinyuan, additional, Chen, Xiaojia, additional, and Hong, An, additional

Published
2021
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42. Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype

Author

Hu, Wen, primary, Zhang, Li, additional, Ferri-Borgogno, Sammy, additional, Kwan, Suet-Ying, additional, Lewis, Kelsey E., additional, Cun, Han T., additional, Yeung, Tsz-Lun, additional, Soliman, Pamela T., additional, Tarapore, Rohinton S., additional, Allen, Joshua E., additional, Guan, Xinyuan, additional, Lu, Karen H., additional, Mok, Samuel C., additional, and Au-Yeung, Chi-Lam, additional

Published
2020
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44. NGS Reveals the Phylogeny of Multi-Organ Metastatic Colon Cancer and Molecular Determinants of Metastasis

Author

Pan, Yangxun, primary, Kong, Lingheng, additional, Yihong, Ling, additional, Wang, Chenwei, additional, Song, Yunda, additional, Zhang, Yuanping, additional, Yuan, Shaohua, additional, Ou, Qingjian, additional, Fang, Yujing, additional, Zhang, Yaojun, additional, Li, Binkui, additional, Chen, Gong, additional, Yuan, Yunfei, additional, Li, Yan, additional, Guan, Xinyuan, additional, Chen, Minshan, additional, Hu, Dandan, additional, and Wan, Desen, additional

Published
2020
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45. Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma

Author

Liao, Yadi, primary, Wang, Chenwei, additional, Yang, Zhiwen, additional, Liu, Wenwu, additional, Yuan, Yichuan, additional, Li, Kai, additional, Zhang, Yuanping, additional, Wang, Yongjin, additional, Shi, Yunxing, additional, Qiu, Yuxiong, additional, Zuo, Dinglan, additional, He, Wei, additional, Qiu, Jiliang, additional, Guan, Xinyuan, additional, Yuan, Yunfei, additional, and Li, Binkui, additional

Published
2020
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46. Dry matter accumulation and phosphorus efficiency response of cotton cultivars to phosphorus and drought

Author

Liu Zhiyong, Wu Zhansheng, Wang Jun, Li Yongshen, Liu Ping, and Guan Xinyuan

Subjects
0106 biological sciences, Physiology, Phosphorus, chemistry.chemical_element, 04 agricultural and veterinary sciences, 01 natural sciences, Arid, chemistry, Agronomy, 040103 agronomy & agriculture, Soil phosphorus, 0401 agriculture, forestry, and fisheries, Environmental science, Dry matter, Cultivar, Agronomy and Crop Science, 010606 plant biology & botany
Abstract

Low soil phosphorus (P) availability and drought are the most recognized growth-limiting factors for the cotton production in arid regions. A pot experiment with P-efficient (Xinluzao19, X19) and P...

Published
2017
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47. The BMP antagonist, SOSTDC1, restrains gastric cancer progression via inactivation of c-Jun signaling

Author

Cui, Yuzhu, Zhang, Feifei, Jia, Yongxu, Sun, Liangzhan, Chen, Miao, Wu, Shayi, Verhoeft, Krista, Li, Yan, Qin, Yanru, Guan, Xinyuan, and Lam, Ka-On

Subjects
Original Article
Abstract

Gastric cancer is commonly diagnosed at an advanced stage when metastasis is almost inevitable. Despite numerous novel regulators have been identified in driving gastric cancer progression, much remains unclear due to the complex nature of cancer. Comparison of the transcriptome profiles of gastric primary tumor tissue, with its matched non-tumor and lymph node metastasis revealed frequent stepwise down-regulation of sclerostin domain containing 1 (SOSTDC1) related with tumor progression. Clinically, deficiency of this gene is associated with shortened survival of patients. Our results suggest that SOSTDC1 confers tumor-suppressive features in gastric cancer and silencing of it accelerates tumor growth and promotes the formation of lung metastasis. Although SOSTDC1 displayed limited inhibition of canonical SMAD-dependent bone morphogenetic proteins (BMP) pathway, it remarkably restrained the c-Jun activation and transcription of c-Jun downstream targets in the noncanonical BMP signaling pathway. Furthermore, c-Jun N-terminal kinase (JNK) blockage attenuated cell proliferative and migrative advantages of SOSTDC1 knockdown cell lines. Our study comprehensively elucidated the role of SOSTDC1 in gastric cancer progression and the results translate into potential therapy for gastric cancer.

Published
2019

48. Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition

Author

Lyu, Zhaojie, Liu, Yuchen, Chen, Miao, Chen, Yacun, Wu, Shayi, He, Anbang, Liao, Xinhui, Zhang, Meng, Wu, Peipei, Mei, Hongbing, Wang, Feng, Cai, Zhiming, and Guan, Xinyuan

Subjects
epithelial-mesenchymal transition (EMT), oncogene, Hippo pathway, transitional cell carcinoma (TCC) of the bladder, prognosis, urologic and male genital diseases, female genital diseases and pregnancy complications, Original Research, CAPG
Abstract

Background: Transitional cell carcinoma (TCC) of the bladder, the major histologic subtype of bladder cancer, is increasing in incidence and mortality, which requires the identification of effective biomarkers. Actin-regulating proteins have recently been proposed as important antitumor druggable targets. As a gelsolin-family actin-modulating protein, CAPG (gelsolin-like actin-capping protein) generated great interest due to its crucial effects in various biological and physiological processes; however, the role and mechanism of CAPG in TCCs remain unknown. Materials and methods: Bioinformatic analysis and immunohistochemistry of clinical specimens were performed to detect the expression level of CAPG. Both in vitro and in vivo assays were used to determine the oncogenic effect of CAPG in TCCs. Male 4–5-week-old BALB/c nude mice were used for in vivo tumorigenesis assays, while SCID mice were used for in vivo metastatic assays. Affymetrix microarray was used to identify the underlying molecular mechanism. Western blot and immunofluorescence were used to validate the expression and localization of proteins. Results: CAPG was frequently upregulated in TCCs and associated with clinical aggressiveness and worse prognosis. Functional assays demonstrated that CAPG could contribute to the tumorigenesis, metastasis and epithelial-mesenchymal transition (EMT) of TCCs both in vitro and in vivo. A novel mechanism that CAPG promoted TCC development via inactivating the Hippo pathway, leading to a nucleus translocation of Yes-associated protein was suggested. Conclusions: The current study identified CAPG as a novel and critical oncogene in TCCs, supporting the pursuit of CAPG as a potential target for TCC intervention.

Published
2018

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