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1,106 results on '"Guan, An-Yang"'

1. Urothelial carcinoma of the renal pelvis with squamous and sarcomatoid differentiation complicated by hydronephrosis and pyelonephritis: a case report and literature review

Author: Zheng-ping Yang, Guan-tian Yang, Zheng Zeng, and Zhuang Gong
Subjects: Upper urinary tract urothelial carcinoma, Squamous differentiation, Sarcomatoid differentiation, Hydronephrosis, Pyelonephritis, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Abstract Background Renal pelvic urothelial carcinoma with multiple histological variants co-occurs with hydronephrosis and pyelonephritis extremely rarely. The diagnosis of renal pelvic urothelial carcinoma can be complicated by these conditions, leading to delayed or missed diagnosis or misdiagnosis. Case presentation We report the evolutionary course of a rare case of renal pelvic urothelial carcinoma containing squamous and sarcomatoid differentiation associated with hydronephrosis and pyelonephritis in a low-functioning kidney. Preoperative clinical and imaging manifestations were highly suggestive of hydronephrosis and pyelonephritis; however, all corresponding therapeutic measures failed. Eventually, nephrectomy was performed, and postoperative pathological examination revealed renal pelvic urothelial carcinoma with squamous and sarcomatoid differentiation. Further residual ureter and bladder cuff resection was refused by the patient. Regular cisplatin-based postoperative chemotherapy and bladder perfusion were arranged, and cystoscopy and imaging examinations were performed regularly for follow-up. Conclusion Hydronephrosis and pyelonephritis can mask the typical clinical and imaging manifestations of renal pelvic urothelial carcinoma. Renal pelvic malignancy should be considered in patients with intractable pyelonephritis and hydronephrosis. There is no standard treatment for renal pelvic carcinoma with multiple pathological types. Radical surgery is considered an appropriate option and should be performed as early as possible. Chemotherapy and immunotherapy may improve patient survival.
Published: 2024
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2. Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage of lymph node metastasis in colorectal cancer

Author: Jin-Ming Chen, Jun He, Jian-Ming Qiu, Guan-Gen Yang, Dong Wang, and Zhong Shen
Subjects: Netrin-1, CD146, S100 proteins, Lymph node metastasis, Colorectal cancer, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Abstract Background The netrin-1/CD146 pathway regulates colorectal cancer (CRC) liver metastasis, angiogenesis, and vascular development. However, few investigations have yet examined the biological function of netrin-1/CD146 complex in CRC. In this work, we investigated the relationship between the netrin-1/CD146 axis and S100 proteins in sentinel lymph node, and revealed a possible new clue for vascular metastasis of CRC. Methods The expression levels of netrin-1 and CD146 proteins in CRC, as well as S100A8 and S100A9 proteins in the sentinel lymph nodes were determined by immunohistochemistry. Using GEPIA and UALCAN, we analyzed netrin-1 and CD146 gene expression in CRC, their association with CRC stage, and their expression levels and prognosis in CRC patients. Results The expression level of netrin-1 in N1a+1b (CRC lymphatic metastasis groups, exculded N1c) was positively increased with N0 (p = 0.012). The level of netrin-1 protein was positively correlated with CD146 protein (p 0.05). Conclusions The netrin-1/CD146 and netrin-1/S100A9 axis in CRC tissues might related with early stage of lymph node metastasis, thus providing potential novel channels for blocking lymphatic metastasis and guiding biomarker discovery in CRC patients.
Published: 2024
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3. Vessel reidentification technology based on deep learning

Author: MO Qianqian, LIU Jun, GUAN Jian, YANG Qilin, PENG Dongliang, CHEN Huajie, GU Yu
Subjects: vessel recognition, deep learning, convolutional neural networks, perspective assistance, Military Science
Abstract: Re-identification technology for pedestrians and vehicles has been successfully applied in the field of intelligence analysis. However, there is a lack of research on re-identification technology for ship targets. In this paper, we propose a double-feature fusion-based maritime defogging re-identification network for intelligence analysis and supervision of ship targets. To reduce the impact of negative samples on features, we adopt a perspective-assisted adaptive query expansion method and a similarity-based feature fusion method. Furthermore, a defogging branch is embedded in the shallow layer of the re-identification branch. This branch utilizes weight sharing technology to extract fog-free features. The defogged image is then reconstructed using upsampling technology and the pyramid model, enhancing the recognition ability of the re-identification network in low-visibility scenarios. Finally, a pseudo-IOU based non-maximum suppression method is proposed to enhance the detection accuracy of ship targets. This method modifies the confidence of the detection frame. Experimental results demonstrate that the proposed method outperforms existing methods, and each module contributes to the network’s performance.
Published: 2024
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4. Realizing the excellent oxidation resistance of an environmental barrier coating through aluminum surface modification

Author: Lin Dong, Wen-Qi Yang, Lin Chen, Guan-Jun Yang, and Chang-Jiu Li
Subjects: environmental barrier coating (ebc), oxidation, modification, diffusion, cracking, Clay industries. Ceramics. Glass, TP785-869
Abstract: The lifetime of Si-based environmental barrier coatings (EBCs) is constrained by thermally grown SiO2 oxide layer (SiO2-TGO), which can cause premature cracking and spalling. To address this issue, a new approach for surface modification using aluminum is proposed. The oxidation performance was examined in a 50 vol% H2O–50 vol% O2 environment at 1350 °C for up to 300 h. The results indicate that a dense ytterbium aluminum garnet (YbAG) layer was formed after modification, decreasing the porosity by 80%. Due to the elimination of fast diffusion channels and the low oxygen permeability of YbAG, aluminum modification significantly reduced the growth rate of SiO2-TGO by nearly two orders of magnitude. Consequently, its thickness decreased by more than 70% after 300 h of exposure. A diffusion-controlled oxidation mechanism indicates that the modified dense surface is equivalent to an initial SiO2 layer with a specific thickness, causing a shift in the oxidation time and increasing the oxidation resistance. This research provides valuable insights for designing Si-based EBC with improved lifetimes.
Published: 2024
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5. Achievement motivation and mental health among medical postgraduates: the chain mediating effect of self-esteem and perceived stress

Author: Mu-yun Ma, Yao Li, Li Guo, and Guan-e Yang
Subjects: medical postgraduates, achievement motivation, depression, anxiety, self-esteem, perceived stress, Psychology, BF1-990
Abstract: IntroductionMedical postgraduates generally experience high levels of depression and anxiety. Previous studies have investigated the impact of various achievement motivations on depression/anxiety among medical students.MethodsThis study focused on self-esteem and perceived stress, examining the internal mechanisms through which achievement motivation affects depression/anxiety. 530 medical postgraduate students (66.04% female and 33.96% male) were administered the Achievement Goal Orientation Scale, Self-Esteem Scale, Perceived Stress Scale, and Depression-Anxiety-Stress Scale.ResultsResults indicated that: (1) mastery-approach goals were negatively correlated with depression/anxiety; mastery-avoidance goals were positively correlated with depression/anxiety; performance-avoidance goals positively predicted depression/anxiety; (2) self-esteem mediated the relationship between achievement motivation and depression/anxiety; (3) perceived stress played a mediating role in the relationship between achievement motivation and depression/anxiety; (4) self-esteem and perceived stress played a chain mediating role in the relationship between achievement motivation and depression/anxiety; (5) there was no significant linear correlation between mastery-approach goals and depression/anxiety.DiscussionAlthough this study employed a cross-sectional design and self-report scales, both of which have certain limitations, the findings still hold significant theoretical and practical implications. The research reveals a mediating pathway between achievement goals and mental health, offering new insights into mental health education for medical graduate students.
Published: 2024
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6. KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges

Author: Chang-Yun Li, Wanhe Wang, Chung-Hang Leung, Guan-Jun Yang, and Jiong Chen
Subjects: Breast cancer, KDM5, Histone demethylation, Therapeutic target, KDM5 inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor for cancer deaths in women. The clinical subtypes of BC include estrogen receptor (ER) positive, progesterone receptor (PR) positive, human epidermal growth factor receptor 2 (HER2) positive, and triple-negative BC (TNBC). Based on the stages and subtypes of BC, various treatment methods are available with variations in the rates of progression-free disease and overall survival of patients. However, the treatment of BC still faces challenges, particularly in terms of drug resistance and recurrence. The study of epigenetics has provided new ideas for treating BC. Targeting aberrant epigenetic factors with inhibitors represents a promising anticancer strategy. The KDM5 family includes four members, KDM5A, KDM5B, KDM5C, and KDMD, all of which are Jumonji C domain-containing histone H3K4me2/3 demethylases. KDM5 proteins have been extensively studied in BC, where they are involved in suppressing or promoting BC depending on their specific upstream and downstream pathways. Several KDM5 inhibitors have shown potent BC inhibitory activity in vitro and in vivo, but challenges still exist in developing KDM5 inhibitors. In this review, we introduce the subtypes of BC and their current therapeutic options, summarize KDM5 family context-specific functions in the pathobiology of BC, and discuss the outlook and pitfalls of KDM5 inhibitors in this disease.
Published: 2024
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7. The complete chloroplast genome of Keteleeria evelyniana Mast var. pendula Hsüeh (Pinaceae), a species with extremely small populations in China

Author: Guan-Song Yang, Yu Qiu, and Zheng-An Yang
Subjects: Chloroplast genome, Keteleeria evelyniana var. pendula, phylogeny, Genetics, QH426-470
Abstract: AbstractKeteleeria evelyniana Mast var. pendula Hsüeh, a typical plant species of extremely small population, is faced to be endangered. The complete chloroplast (cp) genome of K. evelyniana var. pendula has been assembled and annotated for the first time in this study. The complete genome in length was found to be 117,139 bp. The genome annotation revealed a total of 118 genes, including 34 transfer RNA (tRNA) genes, 4 ribosomal RNA (rRNA) genes, and 80 protein-coding genes. The maximum-likelihood phylogenetic tree supported that K. evelyniana var. pendula, K. fortune, K. evelyniana, and K. davidiana are clustered in one branch. This complete chloroplast genome helped us to understand the evolution of K. evelyniana var. pendula. These results laid the foundation for future studies on the conservation of this species.
Published: 2024
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8. Durable dual-state duplex Si–HfO2 with excellent oxidation and cracking resistance

Author: Lin Chen, Jing-Chuan Luo, Wen-Qi Yang, Chang-Jiu Li, and Guan-Jun Yang
Subjects: environmental barrier coatings (ebcs), bond coatings, oxidation, phase transition, cracking, Clay industries. Ceramics. Glass, TP785-869
Abstract: The lifetime of Si bond coatings in environmental barrier coatings is constrained by phase-transition-induced cracking of the SiO2 scale. In this study, Si–HfO2 dual-state duplex composite materials are proposed to address this issue by partially forming HfSiO4 and minimizing the SiO2 content. The as-prepared composite exhibited a structure comprising discrete HfO2 “bricks” embedded in a continuous Si “mortar”, while the oxidized state transformed into discrete HfSiO4 “bricks” within continuous thin SiO2 “mortars”. The results indicate that continuous thin SiO2 contributes to reducing the oxidation rate to a level comparable to that of pure Si, and discrete HfSiO4 particles aid in relieving phase transition-induced stress and inhibiting crack propagation, thereby enhancing oxidation and cracking resistance simultaneously. Consequently, the composite with 20 mol% HfO2 and a mean particle size of ~500 nm at 1370 ℃ exhibited a service lifetime 10 times greater than that of pure Si. This research provides valuable insights for designing Si-based bond coatings with improved service lifetime.
Published: 2024
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9. Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review

Author: Wan‑Jia Qin, Jin-Jin Shi, Ru-Yi Chen, Chang-Yun Li, Yan-Jun Liu, Jian-Fei Lu, Guan-Jun Yang, Jia-Feng Cao, and Jiong Chen
Subjects: CELF1, RNA-binding protein, Diseases, Cancer therapy, Inhibitor, Cytology, QH573-671
Abstract: Abstract RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications of their binding RNA partners, and thereby modulate various physiological and pathological processes. CUG-BP, Elav-like family 1 (CELF1) is a member of the CELF family of RBPs with high affinity to the GU-rich elements in mRNA, and thus exerting control over critical processes including mRNA splicing, translation, and decay. Mounting studies support that CELF1 is correlated with occurrence, genesis and development and represents a potential therapeutical target for these malignant diseases. Herein, we present the structure and function of CELF1, outline its role and regulatory mechanisms in varieties of homeostasis and diseases, summarize the identified CELF1 regulators and their structure–activity relationships, and prospect the current challenges and their solutions during studies on CELF1 functions and corresponding drug discovery, which will facilitate the establishment of a targeted regulatory network for CELF1 in diseases and advance CELF1 as a potential drug target for disease therapy. Graphical Abstract
Published: 2024
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10. Amplifying hepatic L-aspartate levels suppresses CCl4-induced liver fibrosis by reversing glucocorticoid receptor β-mediated mitochondrial malfunction

Author: Rui Su, Hui-Ling Fu, Qian-Xue Zhang, Chen-Yan Wu, Guan-Yu Yang, Jun-Jie Wu, Wen-Jie Cao, Jin Liu, Zhong-Ping Jiang, Cong-Jun Xu, Yong Rao, and Ling Huang
Subjects: Liver fibrosis, L-aspartate, Mitochondrial oxidation, Cholesterol metabolism, Steroid biosynthesis, Corticosterone, Therapeutics. Pharmacology, RM1-950
Abstract: Liver fibrosis is a determinant-stage process of many chronic liver diseases and affected over 7.9 billion populations worldwide with increasing demands of ideal therapeutic agents. Discovery of active molecules with anti-hepatic fibrosis efficacies presents the most attacking filed. Here, we revealed that hepatic L-aspartate levels were decreased in CCl4-induced fibrotic mice. Instead, supplementation of L-aspartate orally alleviated typical manifestations of liver injury and fibrosis. These therapeutic efficacies were alongside improvements of mitochondrial adaptive oxidation. Notably, treatment with L-aspartate rebalanced hepatic cholesterol-steroid metabolism and reduced the levels of liver-impairing metabolites, including corticosterone (CORT). Mechanistically, L-aspartate treatment efficiently reversed CORT-mediated glucocorticoid receptor β (GRβ) signaling activation and subsequent transcriptional suppression of the mitochondrial genome by directly binding to the mitochondrial genome. Knockout of GRβ ameliorated corticosterone-mediated mitochondrial dysfunction and hepatocyte damage which also weakened the improvements of L-aspartate in suppressing GRβ signaling. These data suggest that L-aspartate ameliorates hepatic fibrosis by suppressing GRβ signaling via rebalancing cholesterol-steroid metabolism, would be an ideal candidate for clinical liver fibrosis treatment.
Published: 2024
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11. Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021

Author: Bender, Rose Grace, Sirota, Sarah Brooke, Swetschinski, Lucien R, Dominguez, Regina-Mae Villanueva, Novotney, Amanda, Wool, Eve E, Ikuta, Kevin S, Vongpradith, Avina, Rogowski, Emma Lynn Best, Doxey, Matthew, Troeger, Christopher E, Albertson, Samuel B, Ma, Jianing, He, Jiawei, Maass, Kelsey Lynn, A.F.Simões, Eric, Abdoun, Meriem, Abdul Aziz, Jeza Muhamad, Abdulah, Deldar Morad, Abu Rumeileh, Samir, Abualruz, Hasan, Aburuz, Salahdein, Adepoju, Abiola Victor, Adha, Rishan, Adikusuma, Wirawan, Adra, Saryia, Afraz, Ali, Aghamiri, Shahin, Agodi, Antonella, Ahmadzade, Amir Mahmoud, Ahmed, Haroon, Ahmed, Ayman, Akinosoglou, Karolina, AL-Ahdal, Tareq Mohammed Ali, Al-amer, Rasmieh Mustafa, Albashtawy, Mohammed, AlBataineh, Mohammad T., Alemi, Hediyeh, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Syed Shujait Shujait, Alqahtani, Jaber S, AlQudah, Mohammad, Al-Tawfiq, Jaffar A., Al-Worafi, Yaser Mohammed, Alzoubi, Karem H, Amani, Reza, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amuasi, John H, Anil, Abhishek, Anyanwu, Philip Emeka, Arafat, Mosab, Areda, Damelash, Arefnezhad, Reza, Atalell, Kendalem Asmare, Ayele, Firayad, Azzam, Ahmed Y, Babamohamadi, Hassan, Babin, François-Xavier, Bahurupi, Yogesh, Baker, Stephen, Banik, Biswajit, Barchitta, Martina, Barqawi, Hiba Jawdat, Basharat, Zarrin, Baskaran, Pritish, Batra, Kavita, Batra, Ravi, Bayileyegn, Nebiyou Simegnew, Beloukas, Apostolos, Berkley, James A, Beyene, Kebede A, Bhargava, Ashish, Bhattacharjee, Priyadarshini, Bielicki, Julia A, Bilalaga, Mariah Malak, Bitra, Veera R, Brown, Colin Stewart, Burkart, Katrin, Bustanji, Yasser, Carr, Sinclair, Chahine, Yaacoub, Chattu, Vijay Kumar, Chichagi, Fatemeh, Chopra, Hitesh, Chukwu, Isaac Sunday, Chung, Eunice, Dadana, Sriharsha, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Darban, Isaac, Dash, Nihar Ranjan, Dashti, Mohsen, Dashtkoohi, Mohadese, Dekker, Denise Myriam, Delgado-Enciso, Ivan, Devanbu, Vinoth Gnana Chellaiyan, Dhama, Kuldeep, Diao, Nancy, Do, Thao Huynh Phuong, Dokova, Klara Georgieva, Dolecek, Christiane, Dziedzic, Arkadiusz Marian, Eckmanns, Tim, Ed-Dra, Abdelaziz, Efendi, Ferry, Eftekharimehrabad, Aziz, Eyre, David William, Fahim, Ayesha, Feizkhah, Alireza, Felton, Timothy William, Ferreira, Nuno, Flor, Luisa S, Gaihre, Santosh, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Geffers, Christine, Gerema, Urge, Ghaffari, Kazem, Goldust, Mohamad, Goleij, Pouya, Guan, Shi-Yang, Gudeta, Mesay Dechasa, Guo, Cui, Gupta, Veer Bala, Gupta, Ishita, Habibzadeh, Farrokh, Hadi, Najah R, Haeuser, Emily, Hailu, Wase Benti, Hajibeygi, Ramtin, Haj-Mirzaian, Arvin, Haller, Sebastian, Hamiduzzaman, Mohammad, Hanifi, Nasrin, Hansel, Jan, Hasnain, Md Saquib, Haubold, Johannes, Hoan, Nguyen Quoc, Huynh, Hong-Han, Iregbu, Kenneth Chukwuemeka, Islam, Md. Rabiul, Jafarzadeh, Abdollah, Jairoun, Ammar Abdulrahman, Jalili, Mahsa, Jomehzadeh, Nabi, Joshua, Charity Ehimwenma, Kabir, Md. Awal, Kamal, Zul, Kanmodi, Kehinde Kazeem, Kantar, Rami S., Karimi Behnagh, Arman, Kaur, Navjot, Kaur, Harkiran, Khamesipour, Faham, Khan, M Nuruzzaman, Khan suheb, Mahammed Ziauddin, Khanal, Vishnu, Khatab, Khaled, Khatib, Mahalaqua Nazli, Kim, Grace, Kim, Kwanghyun, Kitila, Aiggan Tamene Tamene, Komaki, Somayeh, Krishan, Kewal, Krumkamp, Ralf, Kuddus, Md Abdul, Kurniasari, Maria Dyah, Lahariya, Chandrakant, Latifinaibin, Kaveh, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Lee, Seung Won, LEPAPE, Alain, Lerango, Temesgen L., Li, Ming-Chieh, Mahboobipour, Amir Ali, Malhotra, Kashish, Mallhi, Tauqeer Hussain, Manoharan, Anand, Martinez-Guerra, Bernardo Alfonso, Mathioudakis, Alexander G., Mattiello, Rita, May, Jürgen, McManigal, Barney, McPhail, Steven M, Mekene Meto, Tesfahun, Mendez-Lopez, Max Alberto Mendez, Meo, Sultan Ayoub, Merati, Mohsen, Mestrovic, Tomislav, Mhlanga, Laurette, Minh, Le Huu Nhat, Misganaw, Awoke, Mishra, Vinaytosh, Misra, Arup Kumar, Mohamed, Nouh Saad, Mohammadi, Esmaeil, Mohammed, Mesud, Mohammed, Mustapha, Mokdad, Ali H, Monasta, Lorenzo, Moore, Catrin E, Motappa, Rohith, Mougin, Vincent, Mousavi, Parsa, Mulita, Francesk, Mulu, Atsedemariam Andualem, Naghavi, Pirouz, Naik, Ganesh R, Nainu, Firzan, Nair, Tapas Sadasivan, Nargus, Shumaila, Negaresh, Mohammad, Nguyen, Hau Thi Hien, Nguyen, Dang H, Nguyen, Van Thanh, Nikolouzakis, Taxiarchis Konstantinos, Noman, Efaq Ali, Nri-Ezedi, Chisom Adaobi, Odetokun, Ismail A., Okwute, Patrick Godwin, Olana, Matifan Dereje, Olanipekun, Titilope O, Olasupo, Omotola O., Olivas-Martinez, Antonio, Ordak, Michal, Ortiz-Brizuela, Edgar, Ouyahia, Amel, Padubidri, Jagadish Rao, Pak, Anton, Pandey, Anamika, Pantazopoulos, Ioannis, Parija, Pragyan Paramita, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Pashaei, Ava, Peprah, Prince, Pham, Hoang Tran, Poddighe, Dimitri, Pollard, Andrew, Ponce-De-Leon, Alfredo, Prakash, Peralam Yegneswaran, Prates, Elton Junio Sady, Quan, Nguyen Khoi, Raee, Pourya, Rahim, Fakher, Rahman, Mosiur, Rahmati, Masoud, Ramasamy, Shakthi Kumaran, Ranjan, Shubham, Rao, Indu Ramachandra, Rashid, Ahmed Mustafa, Rattanavong, Sayaphet, Ravikumar, Nakul, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Reiner, Robert C, Jr., Reyes, Luis Felipe, Roberts, Tamalee, Rodrigues, Mónica, Rosenthal, Victor Daniel, Roy, Priyanka, Runghien, Tilleye, Saeed, Umar, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahoo, Soumya Swaroop, Sahu, Monalisha, Sakshaug, Joseph W, Salami, Afeez Abolarinwa, Saleh, Mohamed A., Salehi omran, Hossein, Sallam, Malik, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Sanjeev, Rama Krishna, Sarasmita, Made Ary, Saravanan, Aswini, Sartorius, Benn, Saulam, Jennifer, Schumacher, Austin E, Seyedi, Seyed Arsalan, Shafie, Mahan, Shahid, Samiah, Sham, Sunder, Shamim, Muhammad Aaqib, Shamshirgaran, Mohammad Ali, Shastry, Rajesh P., Sherchan, Samendra P, Shiferaw, Desalegn, Shittu, Aminu, Siddig, Emmanuel Edwar, Sinto, Robert, Sood, Aayushi, Sorensen, Reed J D, Stergachis, Andy, Stoeva, Temenuga Zhekova, Swain, Chandan Kumar, Szarpak, Lukasz, Tamuzi, Jacques Lukenze, Temsah, Mohamad-Hani, Tessema, Melkamu B Tessema, Thangaraju, Pugazhenthan, Tran, Nghia Minh, Tran, Ngoc-Ha, Tumurkhuu, Munkhtuya, Ty, Sree Sudha, Udoakang, Aniefiok John, Ulhaq, Inam, Umar, Tungki Pratama, Umer, Abdurezak Adem, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Van den Eynde, Jef, Walson, Judd L, Waqas, Muhammad, Xing, Yuhan, Yadav, Mukesh Kumar, Yahya, Galal, Yon, Dong Keon, Zahedi Bialvaei, Abed, Zakham, Fathiah, Zeleke, Abyalew Mamuye, Zhai, Chunxia, Zhang, Zhaofeng, Zhang, Haijun, Zielińska, Magdalena, Zheng, Peng, Aravkin, Aleksandr Y, Vos, Theo, Hay, Simon I, Mosser, Jonathan F., Lim, Stephen S, Naghavi, Mohsen, Murray, Christopher J L, and Kyu, Hmwe Hmwe
Published: 2024
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12. Global, regional, and national burden of major depressive disorder and alcohol use disorder attributed to childhood sexual abuse in 204 countries and territories, 1999–2019: An analysis for the global burden of disease study 2019

Author: Xu, Jin-jie, Xia, Lan, Zheng, Jin-xin, Wang, Cheng-rui, Dun, Wen-wen, Wang, Guang, Wang, Wei, Guan, Shi-Yang, Hu, Jia, Qiao, Yu, Zhang, Wan-jun, Wang, Mei-ti, Fu, Bing-bing, and Wang, Gang
Published: 2025
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13. PERSONALIZED PREDICTIVE VALUE OF ARTIFICIAL INTELLIGENCE FOR ACUTE KIDNEY INJURY AND MORTALITY RISK IN HOSPITALIZED PATIENTS RECEIVING FUROSEMIDE

Author: CUI Lianshun, XU Lingyu, LI Tianyang, GUAN Chen, YANG Chengyu, ZHANG Ningxin, SONG Zhuo, XU Yan
Subjects: furosemide, acute kidney injury, death, artificial intelligence, machine learning, risk assessment, forecasting, Medicine
Abstract: Objective To analyze the association between the use of furosemide in hospitalized patients and the risk of acute kidney injury (AKI) and death based on machine learning and to construct a predictive model. Methods The study inclu-ded 18 998 hospitalized patients who had used furosemide in our hospital from October 2017 to October 2020. The predictive model for evaluating furosemide-associated AKI and mortality risks was established using eight machine learning algorithms including Light Gradient Boosting Machine (LightGBM). The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to assess the discrimination, calibration, and clinical utility of the model. Feature importance analysis of the predictive model with the highest area under the curve (AUC) was conducted using SHAP summary plots, while SHAP force and decision plots were used to explain the individualized decision-making process for predicting AKI and mortality. Results Among the eight machine learning models, the LightGBM model exhibited an AUC of 0.814 for predicting AKI and 0.949 for predicting mortality risk, and the ROC and DCA curves confirmed its strong performance in terms of calibration and clinical application. SHAP summary plots revealed that after using furosemide, crucial factors affecting the occurrence of AKI included serum creatinine, se-rum cystatin C, urine microalbumin/creatinine ratio, and the concurrent use of adrenaline and heparin; meanwhile, the most significant factors leading to mortality in patients using furosemide encompassed 24-hour urinary protein quantification, plasma prothrombin time and international normalized ratio, plasma platelet count, the concurrent use of adrenaline, and the development of AKI du-ring hospitalization. Conclusion A predictive model has been established to assess the risk of AKI occurrence and mortality in hospitalized patients using furosemide by employing machine learning algorithms. This model effectively identifies the influencing factors in predicting the risk of AKI and mortality in these patients.
Published: 2023
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14. The comparison of an accessible C-shaped partial stapled hemorrhoidopexy (C-PSH) versus circular stapled hemorrhoidopexy (CSH) in patients with grade IV hemorrhoids: a retrospective cohort study

Author: Jun He, Meng-Dan Zhou, Wen-Jing Wu, Zhi-Yong Liu, Dong Wang, Guan-Gen Yang, Qin-Yan Yang, and Zhong Shen
Subjects: C-shaped partial stapled hemorrhoidopexy, Partial stapled hemorrhoidopexy, Circular stapled hemorrhoidopexy, Grade IV hemorrhoids, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Abstract Objectives The objectives of this study were to present an accessible C-shaped partial stapled hemorrhoidopexy (C-PSH) in the treatment of grade IV hemorrhoids and to assess long-term outcomes of this technique compared with circular stapled hemorrhoidopexy (CSH). Methods Conventional CSH kits combined with an intestinal spatula were used for performing C-PSH. A total of 256 patients with grade IV hemorrhoids referred to Hangzhou Third People's Hospital between January 2016 and June 2017 were obtained: 122 (47.7%) with C-PSH, and 134 (52.3%) with CSH. After propensity score matching, 222 patients (111 in C-PSH group and 111 in CSH group) were ultimately analyzed. The primary outcome was the five-year recurrence rate of hemorrhoids. Secondary outcomes included intraoperative outcomes, postoperative outcomes and complications. Results The operative time in the C-PSH group was slightly longer than that in the CSH group (p 0.05). Multivariate Cox regression analysis revealed that constipation was an independent prognostic factor for hemorrhoidal recurrence. Conclusions The accessible C-PSH seems to be a safe and effective technique in managing grade IV hemorrhoids. It has advantages in alleviating postoperative pain at first defecation, fecal urgency and major complications compared with CSH. It could be an alternative technique in the treatment of grade IV hemorrhoids.
Published: 2023
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15. Improving fire retardancy of Ti alloys with a refractory ceramic barrier layer

Author: Lin Chen, Yu Dong, Yun-Qi Tong, Mei-Jun Liu, and Guan-Jun Yang
Subjects: Ceramic barrier coating, Abradable seal coating, Fire retardant, Ablation, Melting, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: Reliable service of indispensable titanium alloys in aeroengines is limited by the bottleneck problem of titanium fires. In this study, a tri-layer fire retardant coating with a bi-functional ceramic barrier layer is proposed to suppress titanium fire. Results show that the current coating can increase the fire retardant temperature by ≥ 300 K under droplet ignition. Thermal barrier effect of the YSZ refractory ceramic layer significantly reduces Ti alloy temperature, and oxygen barrier effect prevents active Ti from directly contacting oxygen during the entire ablation process. Therefore, the two barrier effects effectively prevent occurrence of titanium fire. In addition, dissolution of the Ni-based abradable seal coating makes burning TC4 molten droplet extinguished in a short time, thus further inhibiting titanium fire ignition. The present study provides an effective method for reliable service and titanium fire-resistant design of titanium alloys.
Published: 2023
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16. Marine Staurosporine Analogues: Activity and Target Identification in Triple-Negative Breast Cancer

Author: Ru-Yi Chen, Li-Jian Ding, Yan-Jun Liu, Jin-Jin Shi, Jing Yu, Chang-Yun Li, Jian-Fei Lu, Guan-Jun Yang, and Jiong Chen
Subjects: staurosporine analogue, apoptosis, triple-negative breast cancer, cancer stem cells, cell migration, MAP3K11, Biology (General), QH301-705.5
Abstract: Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality and drug resistance and no targeted drug available at present. Compound 4, a staurosporine alkaloid derived from Streptomyces sp. NBU3142 in a marine sponge, exhibits potent anti-TNBC activity. This research investigated its impact on MDA-MB-231 cells and their drug-resistant variants. The findings highlighted that compound 4 inhibits breast cancer cell migration, induces apoptosis, arrests the cell cycle, and promotes cellular senescence in both regular and paclitaxel-resistant MDA-MB-231 cells. Additionally, this study identified mitogen-activated protein kinase kinase kinase 11 (MAP3K11) as a target of compound 4, implicating its role in breast tumorigenesis by affecting cell proliferation, migration, and cell cycle progression.
Published: 2024
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17. TPSQLi: Test Prioritization for SQL Injection Vulnerability Detection in Web Applications

Author: Guan-Yan Yang, Farn Wang, You-Zong Gu, Ya-Wen Teng, Kuo-Hui Yeh, Ping-Hsueh Ho, and Wei-Ling Wen
Subjects: software testing, penetration testing, automatic testing, information security, SQL injection, testing priority, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract: The rapid proliferation of network applications has led to a significant increase in network attacks. According to the OWASP Top 10 Projects report released in 2021, injection attacks rank among the top three vulnerabilities in software projects. This growing threat landscape has increased the complexity and workload of software testing, necessitating advanced tools to support agile development cycles. This paper introduces a novel test prioritization method for SQL injection vulnerabilities to enhance testing efficiency. By leveraging previous test outcomes, our method adjusts defense strength vectors for subsequent tests, optimizing the testing workflow and tailoring defense mechanisms to specific software needs. This approach aims to improve the effectiveness and efficiency of vulnerability detection and mitigation through a flexible framework that incorporates dynamic adjustments and considers the temporal aspects of vulnerability exposure.
Published: 2024
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18. Global burden due to modifiable risk factors for autoimmune diseases, 1990–2021: Temporal trends and socio-demographic inequalities

Author: Guan, Shi-Yang, Zheng, Jin-Xin, Feng, Xin-Yu, Zhang, Shun-Xian, Xu, Shu-Zhen, Wang, Peng, and Pan, Hai-Feng
Published: 2024
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19. Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021

Author: Ledesma, Jorge R, Ma, Jianing, Zhang, Meixin, Basting, Ann V L, Chu, Huong Thi, Vongpradith, Avina, Novotney, Amanda, LeGrand, Kate E, Xu, Yvonne Yiru, Dai, Xiaochen, Nicholson, Sneha Ingle, Stafford, Lauryn K, Carter, Austin, Ross, Jennifer M, Abbastabar, Hedayat, Abdoun, Meriem, Abdulah, Deldar Morad, Aboagye, Richard Gyan, Abolhassani, Hassan, Abrha, Woldu Aberhe, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Aburuz, Salahdein, Addo, Isaac Yeboah, Adepoju, Abiola Victor, Adhikari, Kishor, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afework, Abel, Aghamiri, Shahin, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Danish, Ahmad, Sajjad, Ahmadzade, Amir Mahmoud, Ahmed, Haroon, Ahmed, Mohammed, Ahmed, Ayman, Akinosoglou, Karolina, AL-Ahdal, Tareq Mohammed Ali, Alam, Nazmul, Albashtawy, Mohammed, AlBataineh, Mohammad T, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Endale Alemayehu, Ali, Liaqat, Ali, Zahid, Ali, Syed Shujait Shujait, Allel, Kasim, Altaf, Awais, Al-Tawfiq, Jaffar A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amani, Reza, Amusa, Ganiyu Adeniyi, Amzat, Jimoh, Andrews, Jason R, Anil, Abhishek, Anwer, Razique, Aravkin, Aleksandr Y, Areda, Damelash, Artamonov, Anton A, Aruleba, Raphael Taiwo, Asemahagn, Mulusew A, Atre, Sachin R, Aujayeb, Avinash, Azadi, Davood, Azadnajafabad, Sina, Azzam, Ahmed Y, Badar, Muhammad, Badiye, Ashish D, Bagherieh, Sara, Bahadorikhalili, Saeed, Baig, Atif Amin, Banach, Maciej, Banik, Biswajit, Bardhan, Mainak, Barqawi, Hiba Jawdat, Basharat, Zarrin, Baskaran, Pritish, Basu, Saurav, Beiranvand, Maryam, Belete, Melaku Ashagrie, Belew, Makda Abate, Belgaumi, Uzma Iqbal, Beloukas, Apostolos, Bettencourt, Paulo J G, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhargava, Ashish, Bhat, Vivek, Bhatti, Jasvinder Singh, Bhatti, Gurjit Kaur, Bikbov, Boris, Bitra, Veera R, Bjegovic-Mikanovic, Vesna, Buonsenso, Danilo, Burkart, Katrin, Bustanji, Yasser, Butt, Zahid A, Camargos, Paulo, Cao, Yu, Carr, Sinclair, Carvalho, Felix, Cegolon, Luca, Cenderadewi, Muthia, Cevik, Muge, Chahine, Yaacoub, Chattu, Vijay Kumar, Ching, Patrick R, Chopra, Hitesh, Chung, Eunice, Claassens, Mareli M, Coberly, Kaleb, Cruz-Martins, Natália, Dabo, Bashir, Dadana, Sriharsha, Dadras, Omid, Darban, Isaac, Darega Gela, Jiregna, Darwesh, Aso Mohammad, Dashti, Mahmood, Demessa, Berecha Hundessa, Demisse, Biniyam, Demissie, Solomon, Derese, Awoke Masrie Asrat, Deribe, Kebede, Desai, Hardik Dineshbhai, Devanbu, Vinoth Gnana Chellaiyan, Dhali, Arkadeep, Dhama, Kuldeep, Dhingra, Sameer, Do, Thao Huynh Phuong, Dongarwar, Deepa, Dsouza, Haneil Larson, Dube, John, Dziedzic, Arkadiusz Marian, Ed-Dra, Abdelaziz, Efendi, Ferry, Effendi, Diyan Ermawan, Eftekharimehrabad, Aziz, Ekadinata, Nopryan, Ekundayo, Temitope Cyrus, Elhadi, Muhammed, Elilo, Legesse Tesfaye, Emeto, Theophilus I, Engelbert Bain, Luchuo, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Feizkhah, Alireza, Fetensa, Getahun, Fischer, Florian, Gaipov, Abduzhappar, Gandhi, Aravind P, Gautam, Rupesh K, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebrekidan, Kahsu Gebrekirstos, Ghaffari, Kazem, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Goodridge, Amador, Goyal, Anmol, Guan, Shi-Yang, Gudeta, Mesay Dechasa, Guled, Rashid Abdi, Gultom, Novianti Br, Gupta, Veer Bala, Gupta, Vivek Kumar, Gupta, Sapna, Hagins, Hailey, Hailu, Semira Goitom, Hailu, Wase Benti, Hamidi, Samer, Hanif, Asif, Harapan, Harapan, Hasan, Rumina Syeda, Hassan, Shoaib, Haubold, Johannes, Hezam, Kamal, Hong, Sung Hwi, Horita, Nobuyuki, Hossain, Md. Belal, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Huynh, Hong-Han, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Ilic, Irena M., Ilic, Milena D., Islam, Md. Rabiul, Ismail, Nahlah Elkudssiah, Ismail, Faisal, Jafarzadeh, Abdollah, Jakovljevic, Mihajlo, Jalili, Mahsa, Janodia, Manthan Dilipkumar, Jomehzadeh, Nabi, Jonas, Jost B, Joseph, Nitin, Joshua, Charity Ehimwenma, Kabir, Zubair, Kamble, Bhushan Dattatray, Kanchan, Tanuj, Kandel, Himal, Kanmodi, Kehinde Kazeem, Kantar, Rami S, Karaye, Ibraheem M, Karimi Behnagh, Arman, Kassa, Gebrehiwot G, Kaur, Rimple Jeet, Kaur, Navjot, Khajuria, Himanshu, Khamesipour, Faham, Khan, Yusra H, Khan, M Nuruzzaman, Khan Suheb, Mahammed Ziauddin, Khatab, Khaled, Khatami, Fatemeh, Kim, Min Seo, Kosen, Soewarta, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Kucuk Bicer, Burcu, Kuddus, Md Abdul, Kulimbet, Mukhtar, Kumar, Nithin, Lal, Dharmesh Kumar, Landires, Iván, Latief, Kamaluddin, Le, Trang Diep Thanh, Le, Thao Thi Thu, Ledda, Caterina, Lee, Munjae, Lee, Seung Won, Lerango, Temesgen L, Lim, Stephen S, Liu, Chaojie, Liu, Xuefeng, Lopukhov, Platon D, Luo, Hong, Lv, Hengliang, Mahajan, Preetam Bhalchandra, Mahboobipour, Amir Ali, Majeed, Azeem, Malakan Rad, Elaheh, Malhotra, Kashish, Malik, Muhammad Sajeel Ahmed, Malinga, Lesibana Anthony, Mallhi, Tauqeer Hussain, Manilal, Aseer, Martinez-Guerra, Bernardo Alfonso, Martins-Melo, Francisco Rogerlândio, Marzo, Roy Rillera, Masoumi-Asl, Hossein, Mathur, Vasundhara, Maude, Richard James, Mehrotra, Ravi, Memish, Ziad A, Mendoza, Walter, Menezes, Ritesh G, Merza, Muayad Aghali, Mestrovic, Tomislav, Mhlanga, Laurette, Misra, Sanjeev, Misra, Arup Kumar, Mithra, Prasanna, Moazen, Babak, Mohammed, Hussen, Mokdad, Ali H, Monasta, Lorenzo, Moore, Catrin E, Mousavi, Parsa, Mulita, Francesk, Musaigwa, Fungai, Muthusamy, Raman, Nagarajan, Ahamarshan Jayaraman, Naghavi, Pirouz, Naik, Ganesh R, Naik, Gurudatta, Nair, Sanjeev, Nair, Tapas Sadasivan, Natto, Zuhair S, Nayak, Biswa Prakash, Negash, Hadush, Nguyen, Dang H, Nguyen, Van Thanh, Niazi, Robina Khan, Nnaji, Chukwudi A, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Oancea, Bogdan, Obamiro, Kehinde O, Odetokun, Ismail A, Odo, Daniel Bogale Odo, Odukoya, Oluwakemi Ololade, Oh, In-Hwan, Okereke, Chukwuma O, Okonji, Osaretin Christabel, Oren, Eyal, Ortiz-Brizuela, Edgar, Osuagwu, Uchechukwu Levi, Ouyahia, Amel, P A, Mahesh Padukudru, Parija, Pragyan Paramita, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Patil, Shankargouda, Pawar, Shrikant, Peng, Minjin, Pepito, Veincent Christian Filipino, Peprah, Prince, Perdigão, João, Perico, Norberto, Pham, Hoang Tran, Postma, Maarten J, Prabhu, Attur Ravindra Attur, Prasad, Manya, Prashant, Akila, Prates, Elton Junio Sady, Rahim, Fakher, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmati, Masoud, Rajaa, Sathish, Ramasamy, Shakthi Kumaran, Rao, Indu Ramachandra, Rao, Sowmya J, Rapaka, Deepthi, Rashid, Ahmed Mustafa, Ratan, Zubair Ahmed, Ravikumar, Nakul, Rawaf, Salman, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Reyes, Luis Felipe, Rezaei, Nazila, Rezaeian, Mohsen, Rezahosseini, Omid, Rodrigues, Mónica, Roy, Priyanka, Ruela, Guilherme de Andrade, Sabour, Siamak, Saddik, Basema, Saeed, Umar, Safi, Sher Zaman, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahebkar, Amirhossein, Sahiledengle, Biniyam, Sahoo, Soumya Swaroop, Salam, Nasir, Salami, Afeez Abolarinwa, Saleem, Samreen, Saleh, Mohamed A, Samadi Kafil, Hossein, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Sanjeev, Rama Krishna, Saravanan, Aswini, Sawyer, Susan M, Selvaraj, Siddharthan, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Shah, Pritik A, Shahid, Samiah, Shaikh, Masood Ali, Sham, Sunder, Shamshirgaran, Mohammad Ali, Shanawaz, Mohd, Sharath, Medha, Sherchan, Samendra P, Shetty, Ranjitha S, Shirzad-Aski, Hesamaddin, Shittu, Aminu, Siddig, Emmanuel Edwar, Silva, João Pedro, Singh, Surjit, Singh, Paramdeep, Singh, Harpreet, Singh, Jasvinder A, Siraj, Md Shahjahan, Siswanto, Siswanto, Solanki, Ranjan, Solomon, Yonatan, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Steiropoulos, Paschalis, Swain, Chandan Kumar, Tabuchi, Takahiro, Tampa, Mircea, Tamuzi, Jacques JL Lukenze, Tat, Nathan Y, Tavakoli Oliaee, Razieh, Teklay, Gebrehiwot, Tesfaye, Edosa Geta, Tessema, Belay, Thangaraju, Pugazhenthan, Thapar, Rekha, Thum, Chern Choong Chern, Ticoalu, Jansje Henny Vera, Tleyjeh, Imad M, Tobe-Gai, Ruoyan, Toma, Temesgen Mohammed, Tram, Khai Hoan, Udoakang, Aniefiok John, Umar, Tungki Pratama, Umeokonkwo, Chukwuma David, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, van Boven, Job F M, Varthya, Shoban Babu, Wang, Ziyue, Warsame, Muktar S A, Westerman, Ronny, Wonde, Tewodros Eshete, Yaghoubi, Sajad, Yi, Siyan, Yiğit, Vahit, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Zakham, Fathiah, Zangiabadian, Moein, Zeukeng, Francis, Zhang, Haijun, Zhao, Yang, Zheng, Peng, Zielińska, Magdalena, Salomon, Joshua A, Reiner Jr, Robert C, Naghavi, Mohsen, Vos, Theo, Hay, Simon I, Murray, Christopher J L, and Kyu, Hmwe Hmwe
Published: 2024
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20. The effect of single nucleotide polymorphisms on depression in combination with coronary diseases: a systematic review and meta-analysis

Author: Jing Zhang, Lu Gao, Guan Lin Yang, and De Zhao Kong
Subjects: depression, coronary heart disease, gene polymorphisms, single nucleotide polymorphisms, systematic review, meta-analysis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: BackgroundDepression and coronary heart disease (CHD) have common risk mechanisms. Common single nucleotide polymorphisms (SNPs) may be associated with the risk of depression combined with coronary heart disease.MethodsThis study was designed according to the PRISMA-P guidelines. We will include case-control studies and cohort studies investigating the relationship between gene SNPs and depression and coronary heart disease comorbidities. The Newcastle-Ottawa Scale (NOS) will be used to assess the risk of bias. When measuring dichotomous outcomes, we will use the odds ratio (OR) and 95% confidence interval (95%CIs) in a case-control study. Five genetic models (allele model, homozygous model, co-dominant model, dominant model, and recessive model) will be evaluated for each included study. Subgroup analysis by ethnicity will be performed. If necessary, post hoc analysis will be made according to different types.ResultsA total of 13 studies were included in this study, and the types of genes included are FKBP5 and SGK1 genes that act on glucocorticoid; miR-146a, IL-4-589, IL-6-174, TNF-α-308, CRP-717 genes that act on inflammatory mechanisms; eNOS genes from endothelial cells; HSP70 genes that act on the autoimmune response; ACE2 and MAS1 genes that act to mediate Ang(1-7) in the RAS system; 5-HTTLPR gene responsible for the transport of serotonin 5-HT and neurotrophic factor BDNF gene. There were three studies on 5-HTTLPR and BDNF genes, respectively, while there was only one study targeting FKBP5, SGK1, miR-146a, IL-4-589, IL-6-174, TNF-alpha-308, CRP-717, eNOS, HSP70, ACE2, and MAS1 genes. We did not perform a meta-analysis for genes reported in a single study, and meta-analysis was performed separately for studies exploring the 5-HTTLPR and BDNF genes. The results showed that for the 5-HTTLPR gene, there was a statistically significant association between 5-HTTLPR gene polymorphisms and depression in combination with coronary diseases (CHD-D) under the co-dominant model (LS vs LL: OR 1.76, 95%CI 1.20-2.59; SS vs LL: OR 2.80, 95%CI 1.45 to 5.41), the dominant model (LS+SS vs LL: OR 2.06, 95%CI 1.44 to 2.96), and the homozygous model (SS vs LL: OR 2.80 95%CI 1.45 to 5.5.41) were statistically significant for CHD-D, demonstrating that polymorphisms in the 5-HTTLPR gene are associated with the development of CHD-D and that the S allele in the 5-HTTLPR gene is likely to be a risk factor for CHD-D. For the BDNF gene, there were no significant differences between one of the co-dominant gene models (AA vs GG: OR 6.63, 95%CI 1.44 to 30.64), the homozygous gene model (AA vs GG: OR 6.63,95% CI 1.44 to 30.64), the dominant gene model (GA+AA vs GG: OR4.29, 95%CI 1.05 to 17.45), recessive gene model (AA vs GG+GA: OR 2.71, 95%CI 1.16 to 6.31), and allele model (A vs G: OR 2.59, 95%CI 1.18 to 5.67) were statistically significant for CHD-D, demonstrating that BDNFrs6265 gene polymorphisms are associated with the CHD-D development and that the A allele in the BDNFrs6265 gene is likely to be a risk factor for CHD-D. We analyzed the allele frequencies of SNPs reported in a single study and found that the SNPs in the microRNA146a gene rs2910164, the SNPs in the ACE2 gene rs2285666 and the SNPs in the SGK1 gene rs1743963 and rs1763509 were risk factors for the development of CHD-D. We performed a subgroup analysis of three studies involving the BDNFrs6265 gene. The results showed that European populations were more at risk of developing CHD-D than Asian populations in both dominant model (GA+AA vs GG: OR 10.47, 95%CI 3.53 to 31.08) and co-dominant model (GA vs GG: OR 6.40, 95%CI 1.98 to 20.73), with statistically significant differences. In contrast, the studies involving the 5-HTTLPR gene were all Asian populations, so subgroup analyses were not performed. We performed sensitivity analyses of studies exploring the 5-HTTLPR and BDNF rs6265 genes. The results showed that the results of the allele model, the dominant model, the recessive model, the homozygous model and the co-dominant model for both 5-HTTLPR and BDNF rs6265 genes were stable. Due to the limited number of studies of the 5-HTTLPR and BDNF genes, it was not possible to determine the symmetry of the funnel plot using Begg’s funnel plot and Egger’s test. Therefore, we did not assess publication bias.DiscussionSNPs of the microRNA146a gene at rs2910164, the ACE2 gene at the rs2285666 and the SGK1 gene at rs1743963 and rs1763509, and the SNPs at the 5-HTTLPR and BDNF gene loci are associated with the onset of comorbid depression in coronary heart disease. We recommend that future research focus on studying SNPs’ impact on comorbid depression in coronary heart disease, specifically targeting the 5-HTTLPR and BDNF gene at rs6265.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021229371.
Published: 2024
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21. Critical firing conditions for titanium alloys by molten droplet ignition

Author: Lin Chen, Yu Dong, Yun-Qi Tong, Mei-Jun Liu, and Guan-Jun Yang
Subjects: Titanium fire, Ablation, Molten droplet ignition, Critical conditions, Scaling law, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: Reliable service of indispensable titanium alloys in aeroengines is limited by titanium fire with unclear critical conditions. In this study, critical conditions in the form of parameter phase diagrams for secondary burning were determined by molten droplet ignition. Finite element analysis (FEA) reveals that the molten droplet size (R0), relative oxygen content (Pr), and initial temperature (T0) significantly affect titanium fire following power exponential laws. In addition, Pr and T0 affect ablation synergically, and a unified empirical relationship for critical ablation of titanium alloy is established. Furthermore, the critical T0 of a typical TC4 alloy under 20% Pr is higher than 973 K, which explains the reliable service performance of TC4 alloy at ≤ 873 K in compressors in commerical air engines. In addition, the critical empirical conditions are consistent with the FEA results, and the deviation occurs due to oxidation at T0 ≥ 673 K. Moreover, the ablated TC4 alloy can be divided into five characteristic zones, and loose and porous oxide scales are formed at the front of the titanium fire. The present study points the way towards long-lifetime services of TC4 alloys through sound titanium fire protection strategies.
Published: 2023
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22. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Brauer, Michael, Roth, Gregory A, Aravkin, Aleksandr Y, Zheng, Peng, Abate, Kalkidan Hassen, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abiodun, Olumide, Abiso, Temesgen Lera, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abukhadijah, Hana Jihad Jihad, Aburuz, Salahdein, Abu-Zaid, Ahmed, Adane, Mesafint Molla, Addo, Isaac Yeboah, Addolorato, Giovanni, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afolabi, Aanuoluwapo Adeyimika, Afolabi, Rotimi Felix, Afshin, Ashkan, Afyouni, Shadi, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agbozo, Faith, Aghamiri, Shahin, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Noah, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmed, Ali, Ahmed, Anisuddin, Ahmed, Ayman, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Safoora, Ahmed, Syed Anees, Ajami, Marjan, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akbarialiabad, Hossein, Akhlaghi, Shiva, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akkala, Sreelatha, Akombi-Inyang, Blessing, Al Awaidy, Salah, Al Hasan, Syed Mahfuz, Alahdab, Fares, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Nazmul, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, AlBataineh, Mohammad T, Aldhaleei, Wafa A, Aldridge, Robert W, Alemayohu, Mulubirhan Assefa, Alemu, Yihun Mulugeta, Al-Fatly, Bassam, Al-Gheethi, Adel Ali Saeed, Al-Habbal, Khairat, Alhabib, Khalid F, Alhassan, Robert Kaba, Ali, Abid, Ali, Amjad, Ali, Beriwan Abdulqadir, Ali, Iman, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Waad, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Alla, François, Al-Marwani, Sabah, Al-Mekhlafi, Hesham M, Almustanyir, Sami, Alomari, Mahmoud A, Alonso, Jordi, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Raddadi, Rajaa M, Alrawashdeh, Ahmad, Al-Rifai, Rami Hani, Alrousan, Sahel Majed, Al-Sabah, Salman Khalifah, Alshahrani, Najim Z, Altaany, Zaid, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Alwafi, Hassan, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Al-Zyoud, Walid, Amaechi, Uchenna Anderson, Aman Mohammadi, Masous, Amani, Reza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Ammirati, Enrico, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Anenberg, Susan C, Angappan, Dhanalakshmi, Angus, Colin, Anil, Abhishek, Anil, Sneha, Anjum, Afifa, Anoushiravani, Amir, Antonazzo, Ippazio Cosimo, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Boluwatife Stephen, Anvari, Davood, Anvari, Saeid, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyabolo, Ekenedilichukwu Emmanuel, Anyasodor, Anayochukwu Edward, Apostol, Geminn Louis Carace, Arabloo, Jalal, Arabzadeh Bahri, Razman, Arafat, Mosab, Areda, Demelash, Aregawi, Brhane Berhe, Aremu, Abdulfatai, Armocida, Benedetta, Arndt, Michael Benjamin, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Artanti, Kurnia Dwi, Aruleba, Idowu Thomas, Arumugam, Ashokan, Asbeutah, Akram M, Asgary, Saeed, Asgedom, Akeza Awealom, 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Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
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23. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Author: Bhattacharjee, Natalia V, Schumacher, Austin E, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abiodun, Olumide, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abrigo, Michael R M, Abtahi, Dariush, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Adal, Tadele Girum Girum, Adane, Mesafint Molla, Adeagbo, Oluwafemi Atanda Adeagbo, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adepoju, Abiola Victor, Adetokunboh, Olatunji O, Adetunji, Juliana Bunmi, Adeyinka, Daniel Adedayo, Adeyomoye, Olorunsola Israel, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afolabi, Rotimi Felix, Afyouni, Shadi, Afzal, Muhammad Sohail, Afzal, Saira, Aghamiri, Shahin, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Tauseef, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Meqdad Saleh, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Akalu, Gizachew Taddesse, Akbarialiabad, Hossein, Akinyemi, Rufus Olusola, Akkaif, Mohammed Ahmed, Akkala, Sreelatha, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Al Qadire, Mohammad, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, Albashtawy, Mohammed, AlBataineh, Mohammad T, Alemi, Hediyeh, Alemi, Sharifullah, Alemu, Yihun Mulugeta, Al-Eyadhy, Ayman, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhajri, Noora, Alhalaiqa, Fadwa Alhalaiqa Naji, Alhassan, Robert Kaba, Ali, Abid, Ali, Beriwan Abdulqadir, Ali, 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24. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Ferrari, Alize J, Santomauro, Damian Francesco, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdollahi, Arash, Abdullahi, Auwal, Abegaz, Kedir Hussein, Abeldaño Zuñiga, Roberto Ariel, Aboagye, Richard Gyan, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abualruz, Hasan, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Ackerman, Ilana N, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adepoju, Abiola Victor, Adewuyi, Habeeb Omoponle, Afyouni, Shadi, Afzal, Saira, Afzal, Sina, Agodi, Antonella, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Shahzaib, Ahmed, Ali, Ahmed, Luai A, Ahmed, Muktar Beshir, Ajami, Marjan, Akinosoglou, Karolina, Akkaif, Mohammed Ahmed, Al Hasan, Syed Mahfuz, Alalalmeh, Samer O, Al-Aly, Ziyad, Albashtawy, Mohammed, Aldridge, Robert W, Alemu, Meseret Desalegn, Alemu, Yihun Mulugeta, Alene, Kefyalew Addis, Al-Gheethi, Adel Ali Saeed, 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Theo, and Murray, Christopher J L
Published: 2024
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25. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Naghavi, Mohsen, Ong, Kanyin Liane, Aali, Amirali, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abedi, Aidin, Abegaz, Kedir Hussein, Abhilash, E S, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abtahi, Dariush, Abu Rumeileh, Samir, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Accrombessi, Manfred Mario Kokou, Adal, Tadele Girum, Adamu, Abdu A, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adekanmbi, Victor, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adeyinka, Daniel Adedayo, Adeyomoye, Olorunsola Israel, Admass, Biruk Adie Adie, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afolabi, Aanuoluwapo Adeyimika, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agasthi, Pradyumna, Aggarwal, Manik, Aghamiri, Shahin, Agide, Feleke Doyore, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Mehrunnisha Sharif, Ahmed, Meqdad Saleh, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Akara, Essona Matatom, Akbarialiabad, Hossein, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, 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Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Toriola, Adetunji T, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Nghia Minh, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Irfan, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van de Velde, Sarah M, Van den Eynde, Jef, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Ning, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Watson, Stephanie Louise Watson, Weerakoon, Kosala Gayan, Wei, Melissa Y, Weintraub, Robert G, Weiss, Daniel J, Westerman, Ronny, Whisnant, Joanna L, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wojewodzic, Marcin W, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wolfe, Charles D A, Wondimagegene, Yohannes Addisu, Wong, Yen Jun, Wongsin, Utoomporn, Wu, Ai-Min, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xie, Yang, Xu, Suowen, Xu, Wang-Dong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadollahpour, Ali, Yamagishi, Kazumasa, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesiltepe, Metin, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yigezu, Amanuel, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yismaw, Malede Berihun, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yoon, Seok-Jun, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuh, Faith H, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zangiabadian, Moein, Zar, Heather J, Zare, Iman, Zarrintan, Armin, Zeariya, Mohammed G M, Zeinali, Zahra, Zhang, Haijun, Zhang, Jianrong, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Ziafati, Makan, Zielińska, Magdalena, Zitoun, Osama A, Zoladl, Mohammad, Zou, Zhiyong, Zuhlke, Liesl J, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Wool, Eve E, and Murray, Christopher J L
Published: 2024
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26. Robust zero-energy states in two-dimensional Su-Schrieffer-Heeger topological insulators

Author: Yang, Zhang-Zhao, Guan, An-Yang, Yang, Wen-Jie, Zou, Xin-Ye, and Cheng, Jian-Chun
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Applied Physics
Abstract: The Su-Schrieffer-Heeger (SSH) model on a two-dimensional square lattice has been considered as a significant platform for studying topological multipole insulators. However, due to the highly-degenerate bulk energy bands protected by $ C_{4v} $ and chiral symmetry, the discussion of the zero-energy topological corner states and the corresponding physical realization have been rarely presented. In this work, by tuning the hopping terms to break $ C_{4v} $ symmetry down to $ C_{2v} $ symmetry but with the topological phase invariant, we show that the degeneracies can be removed and a complete band gap can be opened, which provides robust protection for the spectrally isolated zero-energy corner states. Meanwhile, we propose a rigorous acoustic crystalline insulator and therefore these states can be observed directly. Our work reveals the topological properties of the robust zero-energy states, and provides a new way to explore novel topological phenomena., Comment: 22 pages, 7 figures
Published: 2021

27. A General Method to Design Acoustic Higher-Order Topological Insulators

Author: Guan, An-Yang, Yang, Zhang-Zhao, Zou, Xin-Ye, and Cheng, Jian-Chun
Subjects: Physics - Applied Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Acoustic systems that are without limitations imposed by the Fermi level have been demonstrated as significant platform for the exploration of fruitful topological phases. By surrounding the nontrivial domain with trivial "environment", the domain-wall topological states have been theoretically and experimentally demonstrated. In this work, based on the topological crystalline insulator with a kagome lattice, we rigorously derive the corresponding Hamiltonian from the traditional acoustics perspective, and exactly reveal the correspondences of the hopping and onsite terms within acoustic systems. Crucially, these results directly indicate that instead of applying the trivial domain, the soft boundary condition precisely corresponds to the theoretical models which always require generalized chiral symmetry. These results provide a general platform to construct desired acoustic topological devices hosting desired topological phenomena for versatile applications., Comment: 17 pages, 5 figures
Published: 2021
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28. Topological Classical Systems with Generalized Chiral Symmetry

Author: Yang, Zhang-Zhao, Guan, An-Yang, Zou, Xin-Ye, and Cheng, Jian-Chun
Subjects: Condensed Matter - Materials Science, Physics - Applied Physics
Abstract: The bulk band topology of symmetry invariant adiabatic systems in the thermodynamic limit are considered to be determined by the hopping energy. In this work, we present that in closed classical systems, due to generalized chiral symmetry broken, the on-site energy cannot always be regarded as identical and can crucially impact the topological properties of the systems. Based on a finite one-dimensional chain, we demonstrate that the non-equivalent on-site energy of bulk lattices affects the topological phases of the bands, and the on-site energy of end lattices affects the existence of the topological states. Along these lines, the correspondence with generalized chiral symmetry in acoustic system is rigorously proposed. Our work provides a new degree of freedom for topological classical systems, and can be generalized to higher-dimensions and non-Hermitian conditions., Comment: 17 pages, 5 figures
Published: 2021
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29. The State-of-the-Art Antibacterial Activities of Glycyrrhizin: A Comprehensive Review

Author: Ru-Yi Chen, Jin-Jin Shi, Yan-Jun Liu, Jing Yu, Chang-Yun Li, Fan Tao, Jia-Feng Cao, Guan-Jun Yang, and Jiong Chen
Subjects: glycyrrhizin, antibacterial effect, licorice, HMGB1, Biology (General), QH301-705.5
Abstract: Licorice (Glycyrrhiza glabra) is a plant of the genus Glycyrrhiza in the family Fabaceae/Leguminosae and is a renowned natural herb with a long history of medicinal use dating back to ancient times. Glycyrrhizin (GLY), the main active component of licorice, serves as a widely utilized therapeutic agent in clinical practice. GLY exhibits diverse medicinal properties, including anti-inflammatory, antibacterial, antiviral, antitumor, immunomodulatory, intestinal environment maintenance, and liver protection effects. However, current research primarily emphasizes GLY’s antiviral activity, while providing limited insight into its antibacterial properties. GLY demonstrates a broad spectrum of antibacterial activity via inhibiting the growth of bacteria by targeting bacterial enzymes, impacting cell membrane formation, and altering membrane permeability. Moreover, GLY can also bolster host immunity by activating pertinent immune pathways, thereby enhancing pathogen clearance. This paper reviews GLY’s inhibitory mechanisms against various pathogenic bacteria-induced pathological changes, its role as a high-mobility group box 1 inhibitor in immune regulation, and its efficacy in combating diseases caused by pathogenic bacteria. Furthermore, combining GLY with other antibiotics reduces the minimum inhibitory concentration, potentially aiding in the clinical development of combination therapies against drug-resistant bacteria. Sources of information were searched using PubMed, Web of Science, Science Direct, and GreenMedical for the keywords “licorice”, “Glycyrrhizin”, “antibacterial”, “anti-inflammatory”, “HMGB1”, and combinations thereof, mainly from articles published from 1979 to 2024, with no language restrictions. Screening was carried out by one author and supplemented by others. Papers with experimental flaws in their experimental design and papers that did not meet expectations (antifungal papers, etc.) were excluded.
Published: 2024
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30. Application of an Improved GPU Acceleration Strategy for the Smoothed Particle Hydrodynamics Method

Author: GUAN Yanmin, YANG Caihong, KANG Zhuang, ZHOU Li
Subjects: smoothed particle hydrodynamics (sph), parallel computing, dam breaking, computational efficiency, Engineering (General). Civil engineering (General), TA1-2040, Chemical engineering, TP155-156, Naval architecture. Shipbuilding. Marine engineering, VM1-989
Abstract: In order to solve the problem of graphics processing unit (GPU) memory access conflicts possibly caused by the disorder of particles and enhance the computation efficiency, an improved GPU acceleration strategy is proposed by establishing particle reorder technology. The acceleration strategy is applied to the smoothed particle hydrodynamics (SPH) method to simulate the dam breaking with obstacles in three dimensions, and the algorithm is verified by comparing with the experimental results, which obtained a high calculation accuracy. Based on this benchmark example of the SPH, the studies on the effect of particle renumbering and the solution efficiency of the algorithm are conducted by comparing the simulations of different hardware facilities. The results indicate that the particle reorder technology can ensure a stable single-step running time, and can effectively solve the problem of graphic card memory access conflicts that commonly exist in the GPU-SPH algorithm. Furthermore, the GPU parallel algorithm can greatly improve the solution efficiency of the SPH method, and with the increase of particle number, the advantage of drastically reducing the computation time becomes more obvious. The method proposed in this paper provides the possibility to expand the application of the SPH method to solve 3D numerical simulations.
Published: 2023
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31. Boosting electromagnetic wave absorption of Ti3AlC2 by improving effective electrical conductivity

Author: Kai-Yu Guo, Lin Chen, and Guan-Jun Yang
Subjects: anisotropic electrical conductivity, conduction loss (lc), interfacial polarization loss (lip), effective electrical conductivity, co-optimize impedance matching (zin/z0), electromagnetic wave loss, Clay industries. Ceramics. Glass, TP785-869
Abstract: Electromagnetic wave-absorbing (EMA) materials at high temperatures are limited by poor conduction loss (Lc). However, adding conductors simultaneously increases the conduction loss and interfacial polarization loss, leading to a conflict between impedance matching (Zin/Z0) and electromagnetic wave loss. This will prevent electromagnetic waves from entering the EMA materials, finally reducing overall absorbing performance. Here, the effective electrical conductivity (σ) is enhanced by synchronizing particle size and grain number of Ti3AlC2 to increase the conduction loss and avoid the conflict between the impedance matching and the electromagnetic wave loss. As a result, the best-absorbing performance with an effective absorption bandwidth (EAB) of 4.8 GHz (10.6–15.4 GHz) at a thickness of only 1.5 mm is realized, which is the best combination of wide absorption bandwidth and small thickness, and the minimum reflection loss (RLmin) reaches −45.6 dB at 4.1 GHz. In short, this work explores the regulating mechanism of the EMA materials of effective electrical conductivity by simulated calculations using the Vienna ab-initio Simulation Package (VASP) and COMSOL as well as a series of experiments, which provide new insight into a rational design of materials with anisotropic electrical conductivity.
Published: 2023
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32. Tailoring sintering-resistant thermal barrier coatings by considering critical healing width of two-dimensional interlamellar pores

Author: Guang-Rong Li, Tao Liu, Xiao-Tao Luo, Guan-Jun Yang, and Chang-Jiu Li
Subjects: thermal barrier coatings (tbcs), air plasma spraying (aps), multiple connections, grain growth, sintering-resistant structure, Clay industries. Ceramics. Glass, TP785-869
Abstract: Large degradation in thermal insulation and strain tolerance is a main headache and a primary cause of the failure for plasma-sprayed thermal barrier coatings (TBCs) during service. One mechanism behind such degradation is the healing of interlamellar pores formed by multiple connections between edges of a pore, which significantly speeds up healing during thermal exposure. The objective of this study is to obtain sintering-resistant TBCs by tailoring the width of interlamellar pores to avoid multiple connections. Firstly, the mechanism responsible for the multiple connections was revealed. The splat surfaces before and after thermal treatments were characterized via an atomic force microscope (AFM). The roughening of the pore surface occurs during thermal exposure, along with the grain growth inside the splats. Consequently, the local surface height increases, which causes multiple connections and healing of the interlamellar pores. Secondly, critical widths of the interlamellar pores for avoiding the multiple connections during thermal exposure are established by correlating the extent of surface roughening with the growth of individual grains. The height increase of the splat surface and the growth of the grain size (D) were found to increase with the exposure temperature and duration. A relationship linking the height increase and the growth of the grain size induced by thermal exposure in plasma-sprayed ceramic splats was obtained. Finally, composite TBCs were prepared to form wide interlamellar pores in the coatings. Using this design, the increases in the thermal conductivity (λ) and the elastic modulus (E) can be prevented to a large extent. Thus, sintering-resistant TBCs that maintain high thermal insulation and strain tolerance, even after long thermal exposure, can be created.
Published: 2023
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33. Assessing the association between the circulating levels of inflammatory cytokines and the risk of tuberculosis: A bidirectional two-sample mendelian randomization study

Author: Zhang, Shun-Xian, Lu, Zhen-Hui, Wang, Mei-Ti, Shen, Yu-Ping, Duan, Lei, Guan, Shi-Yang, Chen, Mu-Xin, Lu, Yan, Yang, Ming, Wang, Lei, Yang, Guo-Bing, Lv, Wen-Wen, Wang, Ji-Chun, and Zheng, Jin-Xin
Published: 2023
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34. Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Kim, Min Seo, Hwang, Jimin, Yon, Dong Keon, Lee, Seung Won, Jung, Se Yong, Park, Seoyeon, Johnson, Catherine Owens, Stark, Benjamin A, Razo, Christian, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abhari, Amir Parsa, Aboyans, Victor, Adane, Denberu Eshetie Adane, Adebayo, Oladimeji M, Alahdab, Fares, Almustanyir, Sami, Aly, Hany, Ameyaw, Edward Kwabena, Anderson, Jason A, Andrei, Catalina Liliana, Aryan, Zahra, Aujayeb, Avinash, Bagherieh, Sara, Baltatu, Ovidiu Constantin, Banach, Maciej, Bayileyegn, Nebiyou Simegnew, Bearne, Lindsay M, Behnoush, Amir Hossein, Bensenor, Isabela M, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhat, Vivek, Bikbov, Boris, Bintoro, Bagas Suryo, Burkart, Katrin, Cámera, Luis Alberto, Catapano, Alberico L, Chandrasekar, Eeshwar K, Charan, Jaykaran, Chattu, Vijay Kumar, Chi, Gerald, Chukwu, Isaac Sunday, Chung, Sheng-Chia, Cirillo, Massimo, Coberly, Kaleb, Costa, Vera Marisa, Dadras, Omid, Dai, Xiaochen, Do, Thanh Chi, Doshi, Rajkumar, Ekholuenetale, Michael, Elgendy, Islam Y, Elhadi, Muhammed, Fagbamigbe, Adeniyi Francis, Feizkhah, Alireza, Fekadu, Ginenus, Gill, Paramjit Singh, Goldust, Mohamad, Golechha, Mahaveer, Guan, Shi-Yang, Gupta, Vivek Kumar, Hadei, Mostafa, Hadi, Najah R, Hammoud, Ahmad, Hankey, Graeme J, Harlianto, Netanja I, Hasaballah, Ahmed I, Hassan, Shoaib, Hassen, Mohammed Bheser, Heidari, Golnaz, Hostiuc, Mihaela, Ilesanmi, Olayinka Stephen, Iwagami, Masao, Jokar, Mohammad, Jonas, Jost B, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Kazemian, Sina, Keykhaei, Mohammad, Khalaji, Amirmohammad, Khan, Moien AB, Khateri, Sorour, Kibret, Biruk Getahun, Korzh, Oleksii, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Kumar, Akshay, Kumar, Manoj, Kuttikkattu, Ambily, Laksono, Tri, Larijani, Bagher, Le, Thao Thi Thu, Lim, Stephen S, Liu, Xuefeng, Lorkowski, Stefan, Magdy Abd El Razek, Hassan, Malhotra, Kashish, Manla, Yosef, Maugeri, Andrea, Mentis, Alexios-Fotios A, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Mirica, Andreea, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Manish, Mohammad, Yousef, Mokdad, Ali H, Moni, Mohammad Ali, Montasir, Ahmed Al, Moradi, Yousef, Moraga, Paula, Morovatdar, Negar, Mousavi-Aghdas, Seyed Ali, Murray, Christopher J L, Naghavi, Mohsen, Nair, Tapas Sadasivan, Nassereldine, Hasan, Natto, Zuhair S, Nguyen, Dang H, Nguyen, Hien Quang, Nguyen, Van Thanh, Noubiap, Jean Jacques, Oancea, Bogdan, Oliveira, Gláucia Maria Moraes, Owolabi, Mayowa O, Padron-Monedero, Alicia, Perico, Norberto, Petcu, Ionela-Roxana, Radfar, Amir, Rafferty, Quinn, Rahman, Mosiur, Rahman, Muhammad Aziz, Ram, Pradhum, Rashedi, Sina, Rashid, Ahmed Mustafa, Rawaf, Salman, Remuzzi, Giuseppe, Renzaho, Andre M N, Rezaee, Malihe, Roever, Leonardo, Saad, Aly M A, Saadatagah, Seyedmohammad, Sadeghi, Masoumeh, Sahebkar, Amirhossein, Saleh, Mohamed A, Samy, Abdallah M, Santric-Milicevic, Milena M, Sepanlou, Sadaf G, Seylani, Allen, Sharfaei, Sadaf, Shorofi, Seyed Afshin, Singh, Jasvinder A, Singh, Paramdeep, Spartalis, Michael, Sundström, Johan, Tan, Ker-Kan, Teramoto, Masayuki, Tharwat, Samar, Tyrovolas, Stefanos, Valadan Tahbaz, Sahel, Van den Eynde, Jef, Vart, Priya, Wang, Cong, Wang, Fang, Westerman, Ronny, Xia, Juan, Xu, Suowen, Yada, Dereje Y, Yamagishi, Kazumasa, Yonemoto, Naohiro, Zahir, Mazyar, Zangiabadian, Moein, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zoladl, Mohammad, Hay, Simon I, Shin, Jae Il, and Roth, Gregory A
Published: 2023
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35. Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

Author: Wu, Dongze, Jin, Yingzhao, Xing, Yuhan, Abate, Melsew Dagne, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abd-Allah, Foad, Abdelmasseh, Michael, Abdollahifar, Mohammad-Amin, Abdulah, Deldar Morad, Abedi, Aidin, Abedi, Vida, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Abuabara, Katrina, Abyadeh, Morteza, Addo, Isaac Yeboah, Adeniji, Kayode Nelson, Adepoju, Abiola Victor, Adesina, Miracle Ayomikun, Sakilah Adnani, Qorinah Estiningtyas, Afarideh, Mohsen, Aghamiri, Shahin, Agodi, Antonella, Agrawal, Anurag, Aguilera Arriagada, Constanza Elizabeth, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Ali, Ahmed, Ali, Ahmed, Ayman, Aithala, Janardhana P., Ajadi, Abdullateef Abiodun, Ajami, Marjan, Akbarzadeh-Khiavi, Mostafa, Alahdab, Fares, AlBataineh, Mohammad T., Alemi, Sharifullah, Saeed Al-Gheethi, Adel Ali, Ali, Liaqat, Alif, Sheikh Mohammad, Almazan, Joseph Uy, Almustanyir, Sami, Alqahtani, Jaber S., Alqasmi, Ibrahim, Khan Altaf, Ihsan Ullah, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Al-Worafi, Yaser Mohammed, Aly, Hany, Amani, Reza, Amu, Hubert, Amusa, Ganiyu Adeniyi, Andrei, Catalina Liliana, Ansar, Adnan, Ansariniya, Hossein, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arefnezhad, Reza, Arulappan, Judie, Asghari-Jafarabadi, Mohammad, Ashraf, Tahira, Atata, Jamila Abdulhamid, Athari, Seyyed Shamsadin, Atlaw, Daniel, Wahbi Atout, Maha Moh'd, Aujayeb, Avinash, Awan, Asma Tahir, Ayatollahi, Haleh, Azadnajafabad, Sina, Azzam, Ahmed Y., Badawi, Alaa, Badiye, Ashish D., Bagherieh, Sara, Baig, Atif Amin, Bantie, Berihun Bantie, Barchitta, Martina, Bardhan, Mainak, Barker-Collo, Suzanne Lyn, Barone-Adesi, Francesco, Batra, Kavita, Bayileyegn, Nebiyou Simegnew, Behnoush, Amir Hossein, Belgaumi, Uzma Iqbal, Bemanalizadeh, Maryam, Bensenor, Isabela M., Beyene, Kebede A., Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bitaraf, Saeid, Bitra, Veera R., Boloor, Archith, Bora, Kaustubh, Botelho, João Silva, Buchbinder, Rachelle, Calina, Daniela, Cámera, Luis Alberto, Carvalho, Andre F., Kai Chan, Jeffrey Shi, Chattu, Vijay Kumar, Abebe, Endeshaw Chekol, Chichagi, Fatemeh, Choi, Sungchul, Chou, Tzu-Chieh, Chu, Dinh-Toi, Coberly, Kaleb, Costa, Vera Marisa, Couto, Rosa A.S., Cruz-Martins, Natália, Dadras, Omid, Dai, Xiaochen, Damiani, Giovanni, Dascalu, Ana Maria, Dashti, Mohsen, Debela, Sisay Abebe, Dellavalle, Robert Paul, Demetriades, Andreas K., Demlash, Alemayehu Anley, Deng, Xinlei, Desai, Hardik Dineshbhai, Desai, Rupak, Rahman Dewan, Syed Masudur, Dey, Sourav, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dibas, Mahmoud, Dinis-Oliveira, Ricardo Jorge, Diress, Mengistie, Do, Thanh Chi, Doan, Duy Khanh, Dodangeh, Masoud, Dodangeh, Milad, Dongarwar, Deepa, Dube, John, Dziedzic, Arkadiusz Marian, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Eissazade, Negin, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Elemam, Noha Mousaad, Elhadi, Muhammed, Elmehrath, Ahmed O., Abdou Elmeligy, Omar Abdelsadek, Emamverdi, Mehdi, Emeto, Theophilus I., Esayas, Hawi Leul, Eshetu, Habitu Birhan, Etaee, Farshid, Fagbamigbe, Adeniyi Francis, Faghani, Shahriar, Fakhradiyev, Ildar Ravisovich, Fatehizadeh, Ali, Fathi, Mobina, Feizkhah, Alireza, Fekadu, Ginenus, Fereidouni, Mohammad, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C., Ferrara, Pietro, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Foroutan, Behzad, Foroutan, Masoud, Fukumoto, Takeshi, Ganesan, Balasankar, Belete Gemeda, Belete Negese, Ghamari, Seyyed-Hadi, Ghasemi, MohammadReza, Gholamalizadeh, Maryam, Gill, Tiffany K., Gillum, Richard F., Goldust, Mohamad, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Goudarzi, Houman, Guan, Shi-Yang, Guo, Yang, Gupta, Bhawna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haddadi, Rasool, Hadi, Najah R., Halwani, Rabih, Haque, Shafiul, Hasan, Ikramul, Hashempour, Reza, Hassan, Amr, Hassan, Treska S., Hassanzadeh, Sara, Hassen, Mohammed Bheser, Haubold, Johannes, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Heidari-Soureshjani, Reza, Herteliu, Claudiu, Hessami, Kamran, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hosseini, Mohammad-Salar, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilic, Irena M., Ilic, Milena D., Iranmehr, Arad, Iravanpour, Farideh, Ismail, Nahlah Elkudssiah, Iwagami, Masao, Iwu, Chidozie C.D., Jacob, Louis, Jafarinia, Morteza, Jafarzadeh, Abdollah, Jahankhani, Kasra, Jahrami, Haitham, Jakovljevic, Mihajlo, Jamshidi, Elham, Jani, Chinmay T., Janodia, Manthan Dilipkumar, Jayapal, Sathish Kumar, Jayaram, Shubha, Jeganathan, Jayakumar, Jonas, Jost B., Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Vaishali, K., Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kaliyadan, Feroze, Kalroozi, Fatemeh, Kamal, Vineet Kumar, Kandel, Amit, Kandel, Himal, Kanungo, Srikanta, Karami, Jafar, Karaye, Ibraheem M., Karimi, Hanie, Kasraei, Hengameh, Kazemian, Sina, Kebede, Sewnet Adem, Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khamesipour, Faham, Khan, Ejaz Ahmad, Khan, Imteyaz A., Khan, Maseer, Khan, Md Jobair, Khan, Moien A.B., Khan, Muhammad Arslan, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khayat Kashani, Hamid Reza, Kim, Min Seo, Kisa, Adnan, Kisa, Sezer, Koh, Hyun Yong, Kolkhir, Pavel, Korzh, Oleksii, Kotnis, Ashwin Laxmikant, Koul, Parvaiz A., Koyanagi, Ai, Krishan, Kewal, Kuddus, Mohammed, Kulkarni, Vishnutheertha Vishnutheertha, Kumar, Narinder, Kundu, Satyajit, Kurmi, Om P., La Vecchia, Carlo, Lahariya, Chandrakant, Laksono, Tri, Lám, Judit, Latief, Kamaluddin, Lauriola, Paolo, Lawal, Basira Kankia, Thu Le, Thao Thi, Bich Le, Trang Thi, Lee, Munjae, Lee, Seung Won, Lee, Wei-Chen, Lee, Yo Han, Lenzi, Jacopo, Levi, Miriam, Li, Wei, Ligade, Virendra S., Lim, Stephen S., Liu, Gang, Liu, Xuefeng, Llanaj, Erand, Lo, Chun-Han, Machado, Vanessa Sintra, Maghazachi, Azzam A., Mahmoud, Mansour Adam, Mai, Tuan A., Majeed, Azeem, Sanaye, Pantea Majma, Makram, Omar Mohamed, Rad, Elaheh Malakan, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martorell, Miquel, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Mathangasinghe, Yasith, Mathews, Elezebeth, Mathioudakis, Alexander G., Maugeri, Andrea, Mayeli, Mahsa, Carabeo Medina, John Robert, Meles, Gebrekiros Gebremichael, Mendes, José João, Menezes, Ritesh G., Mestrovic, Tomislav, Michalek, Irmina Maria, Micheletti Gomide Nogueira de Sá, Ana Carolina, Mihretie, Ephrem Tesfaye, Nhat Minh, Le Huu, Mirfakhraie, Reza, Mirrakhimov, Erkin M., Misganaw, Awoke, Mohamadkhani, Ashraf, Mohamed, Nouh Saad, Mohammadi, Faezeh, Mohammadi, Soheil, Mohammed, Salahuddin, Mohammed, Shafiu, Mohan, Syam, Mohseni, Anita, Mokdad, Ali H., Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moniruzzaman, Md, Moradi, Yousef, Morovatdar, Negar, Mostafavi, Ebrahim, Mousavi, Parsa, Mukoro, George Duke, Mulita, Admir, Mulu, Getaneh Baye, Murillo-Zamora, Efrén, Musaigwa, Fungai, Mustafa, Ghulam, Muthu, Sathish, Nainu, Firzan, Nangia, Vinay, Swamy, Sreenivas Narasimha, Natto, Zuhair S., Navaraj, Perumalsamy, Nayak, Biswa Prakash, Nazri-Panjaki, Athare, Negash, Hadush, Nematollahi, Mohammad Hadi, Nguyen, Dang H., Hien Nguyen, Hau Thi, Nguyen, Hien Quang, Nguyen, Phat Tuan, Nguyen, Van Thanh, Niazi, Robina Khan, Nikolouzakis, Taxiarchis Konstantinos, Nnyanzi, Lawrence Achilles, Noreen, Mamoona, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Oh, In-Hwan, Okati-Aliabad, Hassan, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olagunju, Andrew T., Olatubi, Matthew Idowu, Olufadewa, Isaac Iyinoluwa, Ordak, Michal, Otstavnov, Nikita, Owolabi, Mayowa O., Mahesh, P.A., Padubidri, Jagadish Rao, Pak, Anton, Pakzad, Reza, Palladino, Raffaele, Pana, Adrian, Pantazopoulos, Ioannis, Papadopoulou, Paraskevi, Pardhan, Shahina, Parthasarathi, Ashwaghosha, Pashaei, Ava, Patel, Jay, Pathan, Aslam Ramjan, Patil, Shankargouda, Paudel, Uttam, Pawar, Shrikant, Pedersini, Paolo, Pensato, Umberto, Pereira, David M., Pereira, Jeevan, Pereira, Maria Odete, Pereira, Renato B., Peres, Mario F.P., Perianayagam, Arokiasamy, Perna, Simone, Petcu, Ionela-Roxana, Pezeshki, Parmida Sadat, Pham, Hoang Tran, Philip, Anil K., Piradov, Michael A., Podder, Indrashis, Podder, Vivek, Poddighe, Dimitri, Sady Prates, Elton Junio, Qattea, Ibrahim, Radfar, Amir, Raee, Pourya, Rafiei, Alireza, Raggi, Alberto, Rahim, Fakher, Rahimi, Mehran, Rahimifard, Mahban, Rahimi-Movaghar, Vafa, Rahman, Md Obaidur, Ur Rahman, Mohammad Hifz, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Mohamed, Rahmani, Shayan, Rahmanian, Vahid, Ramasubramani, Premkumar, Rancic, Nemanja, Rao, Indu Ramachandra, Rashedi, Sina, Rashid, Ahmed Mustafa, Ravikumar, Nakul, Rawaf, Salman, Mohamed Redwan, Elrashdy Moustafa, Rezaei, Nazila, 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Il, Shirkoohi, Reza, Shitaye, Nebiyu Aniley, Shivakumar, K.M., Shivarov, Velizar, Shobeiri, Parnian, Siabani, Soraya, Sibhat, Migbar Mekonnen, Siddig, Emmanuel Edwar, Simpson, Colin R., Sinaei, Ehsan, Singh, Harpreet, Singh, Inderbir, Singh, Jasvinder A., Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Al Mamun Sohag, Abdullah, Solanki, Ranjan, Solikhah, Solikhah, Solomon, Yonatan, Soltani-Zangbar, Mohammad Sadegh, Sun, Jing, Szeto, Mindy D., Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabish, Mohammad, Taheri, Ensiyeh, Tahvildari, Azin, Talaat, Iman M., Lukenze Tamuzi, Jacques J.L., Tan, Ker-Kan, Tat, Nathan Y., Oliaee, Razieh Tavakoli, Tavasol, Arian, Temsah, Mohamad-Hani, Thangaraju, Pugazhenthan, Tharwat, Samar, Tibebu, Nigusie Selomon, Vera Ticoalu, Jansje Henny, Tillawi, Tala, Tiruye, Tenaw Yimer, Tiyuri, Amir, Tovani-Palone, Marcos Roberto, Tripathi, Manjari, Tsegay, Guesh Mebrahtom, Tualeka, Abdul Rohim, Ty, Sree Sudha, Ubah, Chukwudi S., Ullah, Saif, Ullah, Sana, Umair, Muhammad, Umakanthan, Srikanth, Upadhyay, Era, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Tahbaz, Sahel Valadan, Valizadeh, Rohollah, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Verras, Georgios-Ioannis, Villafañe, Jorge Hugo, Vlassov, Vasily, Vo, Danh Cao, Waheed, Yasir, Waris, Abdul, Welegebrial, Brhane Gebrehiwot, Westerman, Ronny, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Willekens, Barbara, Woldegeorgis, Beshada Zerfu, Woldemariam, Melat, Xiao, Hong, Yada, Dereje Y., Yahya, Galal, Yang, Lin, Yazdanpanah, Fereshteh, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Zahir, Mazyar, Zaidi, Syed Saoud, Zangiabadian, Moein, Zare, Iman, Zeineddine, Mohammad A., Zemedikun, Dawit T., Zeru, Naod Gebrekrstos, Zhang, Chen, Zhao, Hanqing, Zhong, Chenwen, Zielińska, Magdalena, Zoladl, Mohammad, Zumla, Alimuddin, Guo, Cui, and Tam, Lai-shan
Published: 2023
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36. The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond

Author: Meng-Yao Niu, Yan-Jun Liu, Jin-Jin Shi, Ru-Yi Chen, Shun Zhang, Chang-Yun Li, Jia-Feng Cao, Guan-Jun Yang, and Jiong Chen
Subjects: USP36, cancer, ubiquitination, deubiquitinating enzyme, Microbiology, QR1-502
Abstract: The balance between ubiquitination and deubiquitination is instrumental in the regulation of protein stability and maintenance of cellular homeostasis. The deubiquitinating enzyme, ubiquitin-specific protease 36 (USP36), a member of the USP family, plays a crucial role in this dynamic equilibrium by hydrolyzing and removing ubiquitin chains from target proteins and facilitating their proteasome-dependent degradation. The multifaceted functions of USP36 have been implicated in various disease processes, including cancer, infections, and inflammation, via the modulation of numerous cellular events, including gene transcription regulation, cell cycle regulation, immune responses, signal transduction, tumor growth, and inflammatory processes. The objective of this review is to provide a comprehensive summary of the current state of research on the roles of USP36 in different pathological conditions. By synthesizing the findings from previous studies, we have aimed to increase our understanding of the mechanisms underlying these diseases and identify potential therapeutic targets for their treatment.
Published: 2024
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37. Editorial: Emerging talents in comparative immunology: 2022

Author: Yan-Jun Liu, Xin-Jiang Lu, Chris Hauton, Guan-Jun Yang, and Jiong Chen
Subjects: comparative immunology, LECT2, P2X receptor, germinal center, MCSF-2, Immunologic diseases. Allergy, RC581-607
Published: 2023
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38. Global burden and risk factors of musculoskeletal disorders among adolescents and young adults in 204 countries and territories, 1990–2019

Author: Guan, Shi-Yang, Zheng, Jin-Xin, Sam, Napoleon Bellua, Xu, Shengqian, Shuai, Zongwen, and Pan, Faming
Published: 2023
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39. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

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Ali, Ahmed, Luai A, Ahmed, Syed Anees, Ajami, Marjan, Akinyemi, Rufus Olusola, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, AL-Ahdal, Tareq Mohammed Ali, Alalwan, Tariq A, Al-Aly, Ziyad, AlBataineh, Mohammad T, Alcalde-Rabanal, Jacqueline Elizabeth, Alemi, Sharifullah, Ali, Hassam, Alinia, Tahereh, Aljunid, Syed Mohamed, Almustanyir, Sami, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Amiri, Sohrab, Amusa, Ganiyu Adeniyi, Andrei, Catalina Liliana, Anjana, Ranjit Mohan, Ansar, Adnan, Ansari, Golnoosh, Ansari-Moghaddam, Alireza, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Aravkin, Aleksandr Y, Areda, Demelash, Arifin, Hidayat, Arkew, Mesay, Armocida, Benedetta, Ärnlöv, Johan, Artamonov, Anton A, Arulappan, Judie, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Aryan, Zahra, Asemu, Mulu Tiruneh, Asghari-Jafarabadi, Mohammad, Askari, Elaheh, Asmelash, Daniel, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, 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Virginia, Boloor, Archith, Brauer, Michael, Brazo-Sayavera, Javier, Brenner, Hermann, Butt, Zahid A, Calina, Daniela, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Yin, Cao, Chao, Car, Josip, Carvalho, Márcia, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Cerin, Ester, Chadwick, Joshua, Chandrasekar, Eeshwar K, Chanie, Gashaw Sisay, Charan, Jaykaran, Chattu, Vijay Kumar, Chauhan, Kirti, Cheema, Huzaifa Ahmad, Chekol Abebe, Endeshaw, Chen, Simiao, Cherbuin, Nicolas, Chichagi, Fatemeh, Chidambaram, Saravana Babu, Cho, William C S, Choudhari, Sonali Gajanan, Chowdhury, Rajiv, Chowdhury, Enayet Karim, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Sheng-Chia, Coberly, Kaleb, Columbus, Alyssa, Contreras, Daniela, Cousin, Ewerton, Criqui, Michael H, Cruz-Martins, Natália, Cuschieri, Sarah, Dabo, Bashir, Dadras, Omid, Dai, Xiaochen, Damasceno, Albertino Antonio Moura, Dandona, Rakhi, Dandona, Lalit, Das, Saswati, Dascalu, Ana Maria, Dash, Nihar Ranjan, Dashti, Mohsen, 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Hasan, S M Mahmudul, Hasan, Syed Shahzad, Hasani, Hamidreza, Hassanipour, Soheil, Hassen, Mohammed Bheser, Haubold, Johannes, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Hessami, Kamran, Hiraike, Yuta, Holla, Ramesh, Hossain, Sahadat, Hossain, Md Shakhaoat, Hosseini, Mohammad-Salar, Hosseinzadeh, Mehdi, Hosseinzadeh, Hassan, Huang, Junjie, Huda, Md Nazmul, Hussain, Salman, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ilic, Irena M, Ilic, Milena D, Inbaraj, Leeberk Raja, Iqbal, Afrin, Islam, Sheikh Mohammed Shariful, Islam, Rakibul M, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Itumalla, Ramaiah, Iwagami, Masao, Iwu, Chidozie C D, Iyamu, Ihoghosa Osamuyi, Iyasu, Assefa N, Jacob, Louis, Jafarzadeh, Abdollah, Jahrami, Haitham, Jain, Rajesh, Jaja, Chinwe, Jamalpoor, Zahra, Jamshidi, Elham, Janakiraman, Balamurugan, Jayanna, Krishnamurthy, Jayapal, Sathish Kumar, Jayaram, Shubha, Jayawardena, Ranil, Jebai, Rime, Jeong, Wonjeong, Jin, Yinzi, Jokar, Mohammad, Jonas, Jost B, Joseph, Nitin, Joseph, Abel, Joshua, Charity Ehimwenma, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Kaambwa, Billingsley, Kabir, Ali, Kabthymer, Robel Hussen, Kadashetti, Vidya, Kahe, Farima, Kalhor, Rohollah, Kandel, Himal, Karanth, Shama D, Karaye, Ibraheem M, Karkhah, Samad, Katoto, Patrick DMC, Kaur, Navjot, Kazemian, Sina, Kebede, Sewnet Adem, Khader, Yousef Saleh, Khajuria, Himanshu, Khalaji, Amirmohammad, Khan, Moien AB, Khan, Maseer, Khan, Ajmal, Khanal, Saval, Khatatbeh, Moawiah Mohammad, Khater, Amir M, Khateri, Sorour, khorashadizadeh, Fatemeh, Khubchandani, Jagdish, Kibret, Biruk Getahun, Kim, Min Seo, Kimokoti, Ruth W, Kisa, Adnan, Kivimäki, Mika, Kolahi, Ali-Asghar, Komaki, Somayeh, Kompani, Farzad, Koohestani, Hamid Reza, Korzh, Oleksii, Kostev, Karel, Kothari, Nikhil, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Yuvaraj, Kuate Defo, Barthelemy, Kuddus, Mohammed, Kuddus, Md Abdul, Kumar, Rakesh, Kumar, Harish, Kundu, Satyajit, Kurniasari, Maria Dyah, Kuttikkattu, Ambily, La Vecchia, Carlo, Lallukka, Tea, Larijani, Bagher, Larsson, Anders O, Latief, Kamaluddin, Lawal, Basira Kankia, Le, Thao Thi Thu, Le, Trang Thi Bich, Lee, Shaun Wen Huey, Lee, Munjae, Lee, Wei-Chen, Lee, Paul H, Lee, Sang-woong, Lee, Seung Won, Legesse, Samson Mideksa, Lenzi, Jacopo, Li, Yongze, Li, Ming-Chieh, Lim, Stephen S, Lim, Lee-Ling, Liu, Xuefeng, Liu, Chaojie, Lo, Chun-Han, Lopes, Graciliana, Lorkowski, Stefan, Lozano, Rafael, Lucchetti, Giancarlo, Maghazachi, Azzam A, Mahasha, Phetole Walter, Mahjoub, Soleiman, Mahmoud, Mansour Adam, Mahmoudi, Razzagh, Mahmoudimanesh, Marzieh, Mai, Anh Tuan, Majeed, Azeem, Majma Sanaye, Pantea, Makris, Konstantinos Christos, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mamun, Abdullah A, Mansouri, Borhan, Marateb, Hamid Reza, Mardi, Parham, Martini, Santi, Martorell, Miquel, Marzo, Roy Rillera, Masoudi, Reza, Masoudi, Sahar, Mathews, Elezebeth, Maugeri, Andrea, Mazzaglia, Giampiero, Mekonnen, Teferi, Meshkat, Mahboobeh, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Tomasz, Michalek, Irmina Maria, Minh, Le Huu Nhat, Mini, GK, Miranda, J Jaime, Mirfakhraie, Reza, Mirrakhimov, Erkin M, Mirza-Aghazadeh-Attari, Mohammad, Misganaw, Awoke, Misgina, Kebede Haile, Mishra, Manish, Moazen, Babak, Mohamed, Nouh Saad, Mohammadi, Esmaeil, Mohammadi, Mohsen, Mohammadian-Hafshejani, Abdollah, Mohammadshahi, Marita, Mohseni, Alireza, Mojiri-forushani, Hoda, Mokdad, Ali H, Momtazmanesh, Sara, Monasta, Lorenzo, Moniruzzaman, Md, Mons, Ute, Montazeri, Fateme, Moodi Ghalibaf, AmirAli, Moradi, Yousef, Moradi, Maryam, Moradi Sarabi, Mostafa, Morovatdar, Negar, Morrison, Shane Douglas, Morze, Jakub, Mossialos, Elias, Mostafavi, Ebrahim, Mueller, Ulrich Otto, Mulita, Francesk, Mulita, Admir, Murillo-Zamora, Efrén, Musa, Kamarul Imran, Mwita, Julius C, Nagaraju, Shankar Prasad, Naghavi, Mohsen, Nainu, Firzan, Nair, Tapas Sadasivan, Najmuldeen, Hastyar Hama Rashid, Nangia, Vinay, Nargus, Shumaila, Naser, Abdallah Y, Nassereldine, Hasan, Natto, Zuhair S, Nauman, Javaid, Nayak, Biswa Prakash, Ndejjo, Rawlance, Negash, Hadush, Negoi, Ruxandra Irina, Nguyen, Hau Thi Hien, Nguyen, Dang H, Nguyen, Phat Tuan, Nguyen, Van Thanh, Nguyen, Hien Quang, Niazi, Robina Khan, Nigatu, Yeshambel T, Ningrum, Dina Nur Anggraini, Nizam, Muhammad A, Nnyanzi, Lawrence Achilles, Noreen, Mamoona, Noubiap, Jean Jacques, Nzoputam, Ogochukwu Janet, Nzoputam, Chimezie Igwegbe, Oancea, Bogdan, Odogwu, Nkechi Martina, Odukoya, Oluwakemi Ololade, Ojha, Vivek Anand, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olufadewa, Isaac Iyinoluwa, Onwujekwe, Obinna E, Ordak, Michal, Ortiz, Alberto, Osuagwu, Uchechukwu Levi, Oulhaj, Abderrahim, Owolabi, Mayowa O, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Palladino, Raffaele, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pandey, Ashok, Pandey, Anamika, Pandi-Perumal, Seithikurippu R, Pantea Stoian, Anca Mihaela, Pardhan, Shahina, Parekh, Tarang, Parekh, Utsav, Pasovic, Maja, Patel, Jay, Patel, Jenil R, Paudel, Uttam, Pepito, Veincent Christian Filipino, Pereira, Marcos, Perico, Norberto, Perna, Simone, Petcu, Ionela-Roxana, Petermann-Rocha, Fanny Emily, Podder, Vivek, Postma, Maarten J, Pourali, Ghazaleh, Pourtaheri, Naeimeh, Prates, Elton Junio Sady, Qadir, Mirza Muhammad Fahd, Qattea, Ibrahim, Raee, Pourya, Rafique, Ibrar, Rahimi, Mehran, Rahimifard, Mahban, Rahimi-Movaghar, Vafa, Rahman, Md Obaidur, Rahman, Muhammad Aziz, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahman, Md Mosfequr, Rahmani, Mohamed, Rahmani, Shayan, Rahmanian, Vahid, Rahmawaty, Setyaningrum, Rahnavard, Niloufar, Rajbhandari, Bibek, Ram, Pradhum, Ramazanu, Sheena, Rana, Juwel, Rancic, Nemanja, Ranjha, Muhammad Modassar Ali Nawaz, Rao, Chythra R, Rapaka, Deepthi, Rasali, Drona Prakash, Rashedi, Sina, Rashedi, Vahid, Rashid, Ahmed Mustafa, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, Salman, Rawal, Lal, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Rengasamy, Kannan RR, Renzaho, Andre M N, Reyes, Luis Felipe, Rezaei, Nima, Rezaei, Nazila, Rezaeian, Mohsen, Rezazadeh, Hossein, Riahi, Seyed Mohammad, Rias, Yohanes Andy, Riaz, Muhammad, Ribeiro, Daniela, Rodrigues, Mónica, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Rohloff, Peter, Roshandel, Gholamreza, Roustazadeh, Abazar, Rwegerera, Godfrey M, Saad, Aly M A, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sabzmakan, Leila, Saddik, Basema, Sadeghi, Erfan, Saeed, Umar, Saeedi Moghaddam, Sahar, Safi, Sare, Safi, Sher Zaman, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahoo, Harihar, Saif-Ur-Rahman, KM, Sajid, Mirza Rizwan, Salahi, Sarvenaz, Salahi, Saina, Saleh, Mohamed A, Salehi, Mohammad Amin, Salomon, Joshua A, Sanabria, Juan, Sanjeev, Rama Krishna, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Sarasmita, Made Ary, Sargazi, Saman, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sawhney, Monika, Schlaich, Markus P, Schmidt, Maria Inês, Schuermans, Art, Seidu, Abdul-Aziz, Senthil Kumar, Nachimuthu, Sepanlou, Sadaf G, Sethi, Yashendra, Seylani, Allen, Shabany, Maryam, Shafaghat, Tahereh, Shafeghat, Melika, Shafie, Mahan, Shah, Nilay S, Shahid, Samiah, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sharfaei, Sadaf, Shashamo, Bereket Beyene, Shiri, Rahman, Shittu, Aminu, Shivakumar, K M, Shivalli, Siddharudha, Shobeiri, Parnian, Shokri, Fereshteh, Shuval, Kerem, Sibhat, Migbar Mekonnen, Silva, Luís Manuel Lopes Rodrigues, Simpson, Colin R, Singh, Jasvinder A, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Skryabina, Anna Aleksandrovna, Sohag, Abdullah Al Mamun, Soleimani, Hamidreza, Solikhah, Solikhah, Soltani-Zangbar, Mohammad Sadegh, Somayaji, Ranjani, Sorensen, Reed J D, Starodubova, Antonina V, Sujata, Sujata, Suleman, Muhammad, Sun, Jing, Sundström, Johan, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaeizadeh, Seyed-Amir, Tabish, Mohammad, Taheri, Majid, Taheri, Ensiyeh, Taki, Elahe, Tamuzi, Jacques JL Lukenze, Tan, Ker-Kan, Tat, Nathan Y, Taye, Birhan Tsegaw, Temesgen, Worku Animaw, Temsah, Mohamad-Hani, Tesler, Riki, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapa, Rajshree, Tharwat, Samar, Thomas, Nihal, Ticoalu, Jansje Henny Vera, Tiyuri, Amir, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Trico, Domenico, Trihandini, Indang, Tripathy, Jaya Prasad, Tromans, Samuel Joseph, Tsegay, Guesh Mebrahtom, Tualeka, Abdul Rohim, Tufa, Derara Girma, Tyrovolas, Stefanos, Ullah, Sana, Upadhyay, Era, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, van Daalen, Kim Robin, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vaziri, Siavash, Verma, Madhur verma, Verras, Georgios-Ioannis, Vo, Danh Cao, Wagaye, Birhanu, Waheed, Yasir, Wang, Ziyue, Wang, Yanqing, Wang, Cong, Wang, Fang, Wassie, Gizachew Tadesse, Wei, Melissa Y Wei, Weldemariam, Abrha Hailay, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Wu, YiFan, Wulandari, Ratna DWI, Xia, Juan, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Yada, Dereje Y, Yang, Lin, Yatsuya, Hiroshi, Yesiltepe, Metin, Yi, Siyan, Yohannis, Hunachew Kibret, Yonemoto, Naohiro, You, Yuyi, Zaman, Sojib Bin, Zamora, Nelson, Zare, Iman, Zarea, Kourosh, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zeru, Naod Gebrekrstos, Zhang, Zhi-Jiang, Zhong, Chenwen, Zhou, Jingjing, Zielińska, Magdalena, Zikarg, Yossef Teshome, Zodpey, Sanjay, Zoladl, Mohammad, Zou, Zhiyong, Zumla, Alimuddin, Zuniga, Yves Miel H, Magliano, Dianna J, Murray, Christopher J L, Hay, Simon I, and Vos, Theo
Published: 2023
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40. Heterogeneous layered structure in thermal barrier coatings by plasma spray-physical vapor deposition

Author: Yan-Hong Lu, Lu Huang, Mei-Jun Liu, Guan-Jun Yang, and Chang-Jiu Li
Subjects: transient temperature, in-situ deposit surface, heterogeneous layered structure, fracture mechanism, plasma spray-physical vapor deposition (ps-pvd), Clay industries. Ceramics. Glass, TP785-869
Abstract: The unique columnar structure endows thermal barrier coatings (TBCs) prepared by plasma spray-physical vapor deposition (PS-PVD) with high thermal insulation and long lifetime. However, the coating delamination failure resulting from an intra-column fracture (within a column rather than between columns) is a bottleneck in the solid dust particle impact environment for aero-engine. To clarify the intra-column fracture mechanism, a basic layer deposition model is developed to explore a heterogeneous weak-to-strong layered structure formed by a local transient in-situ deposit temperature. During the PS-PVD, an in-situ deposit surface is continuously updated due to constantly being covered by vapor condensation, showing a transient temperature, which means that the in-situ deposit surface temperature rises sharply in short period of 0.2 s of depositing a thin layer during a single pass. Meanwhile, the increasing temperature of the in-situ deposit surface results in an experimentally observed heterogeneous weak-to-strong structure, showing a continuous transition from a porous weak structure at the bottom region to a dense strong structure at the top region. This structure easily makes the intra-column fracture at the porous weak region. The results shed light on improving TBC lifetime by restraining the intra-column fracture.
Published: 2023
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41. Improving oxidation resistance of Si coating by isolated-particle healing

Author: Lin Chen, Jia-Hui Li, Guo-Qiang Wang, You-Feng Bo, and Guan-Jun Yang
Subjects: Si coating, IPH treatment, Oxidation rate, Cracking, Phase transformation, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: Atmospheric plasma sprayed dense Si coatings have excellent potential for high-temperature oxidation resistance. However, numerous isolated spherical particles on the coating surface result in rapid oxidation and a large local TGO thickness. In the present study, isolated particle healing (IPH) treatment was proposed to eliminate these isolated particles. Then, the related structure evolution and oxidation kinetics of Si coatings were investigated. Finally, the failure mechanism of TGO after oxidation was identified. The results show that the IPH treatment makes isolated particles diffuse, connect with and then immerse themselves into the bulk coating surface, thereby contributing to both surface smoothing and coating densification. Consequently, the localized large thickness in the TGO scale is eliminated, and the overall oxidation rates of the IPH Si coating decrease by ∼24% compared with the as-sprayed coating. The β→α phase transformation of polymorphic cristobalite with a volume reduction of ∼4.5% is the main cause for TGO channel cracking and is not suppressed by IPH treatment, which points out future directions for better antioxidant Si coatings.
Published: 2022
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42. Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

Author: Shasha Cheng, Guan-Jun Yang, Wanhe Wang, Dik-Lung Ma, and Chung-Hang Leung
Subjects: Cancer stem cells, CDK9-cyclin T1, Epithelial mesenchymal transition, Protein–protein interaction (PPI), Triple-negative breast cancer (TNBC), Medicine (General), R5-920, Genetics, QH426-470
Abstract: Triple-negative breast cancer (TNBC) is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer subtypes. The epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs) have been proposed as important mechanisms underlying TNBC metastasis. CDK9 is highly expressed in breast cancer, including TNBC, where it promotes EMT and induces cancer cell stemness. In this study, we have identified a tetrahydroisoquinoline derivative (compound 1) as a potent and selective CDK9-cyclin T1 inhibitor via virtual screening. Interestingly, by targeting the ATP binding site, compound 1 not only inhibited CDK9 activity but also disrupted the CDK9-cyclin T1 protein–protein interaction (PPI). Mechanistically, compound 1 reversed EMT and reduced the ratio of CSCs by blocking the CDK9-cyclin T1 interaction, leading to reduced TNBC cell proliferation and migration. To date, compound 1 is the first reported tetrahydroisoquinoline-based CDK9-cyclin T1 ATP-competitive inhibitor that also interferes with the interaction between CDK9 and cyclin T1. Compound 1 may serve as a promising scaffold for developing more selective and potent anti-TNBC agents. Our work also provides insight into the role of the CDK9-cyclin T1 PPI on EMT and CSCs and highlights the feasibility and significance of targeting CDK9 for the treatment of TNBC.
Published: 2022
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43. Application of MOF-based nanotherapeutics in light-mediated cancer diagnosis and therapy

Author: Dan Zhao, Wang Zhang, Shuang Yu, Si-Lei Xia, Ya-Nan Liu, and Guan-Jun Yang
Subjects: Light-mediated, Metal–organic frameworks, Nanotherapeutics, Cancer diagnosis, Therapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
Abstract: Abstract Light-mediated nanotherapeutics have recently emerged as promising strategies to precisely control the activation of therapeutic reagents and imaging probe both in vitro and in vivo, largely ascribed to their unique properties, including minimally invasive capabilities and high spatiotemporal resolution. Nanoscale metal–organic frameworks (NMOFs), a new family of hybrid materials consisting of metal attachment sites and bridging ligands, have been explored as a new platform for enhanced cancer diagnosis and therapy due to their tunable size, modifiable surface, good biocompatibility, high agent loading and, most significantly, their ability to be preferentially deposited in tumors through enhanced permeability and retention (EPR). Especially the light-driven NMOF-based therapeutic platform, which not only allow for increased laser penetration depth and enhanced targeting, but also enable imaging-guided or combined treatments. This review provides up-to-date developments of NMOF-based therapeutic platforms for cancer treatment with emphasis on light-triggered therapeutic strategies and introduces their advances in cancer diagnosis and therapy in recent years. Graphic Abstract
Published: 2022
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44. Editorial: Community series in epigenetics of the immune component of inflammation-volume II

Author: Yan-Jun Liu, Hai-Jing Zhong, Haitao Wang, Cheong-Meng Chong, and Guan-Jun Yang
Subjects: epigenetics, immune response, inflammation, genome modification, posttranscriptional modifications, post-translational modifications, Immunologic diseases. Allergy, RC581-607
Published: 2023
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45. Progress in ceramic materials and structure design toward advanced thermal barrier coatings

Author: Zhi-Yuan Wei, Guo-Hui Meng, Lin Chen, Guang-Rong Li, Mei-Jun Liu, Wei-Xu Zhang, Li-Na Zhao, Qiang Zhang, Xiao-Dong Zhang, Chun-Lei Wan, Zhi-Xue Qu, Jing Feng, Ling Liu, Hui Dong, Ze-Bin Bao, Xiao-Feng Zhao, Xiao-Feng Zhang, Lei Guo, Liang Wang, Bo Cheng, Wei-Wei Zhang, Peng-Yun Xu, Guan-Jun Yang, Hong-Neng Cai, Hong Cui, You Wang, Fu-Xing Ye, Zhuang Ma, Wei Pan, Min Liu, Ke-Song Zhou, and Chang-Jiu Li
Subjects: thermal barrier coatings (TBCs), ceramic material, degradation and failure, structure design, long lifetime, Clay industries. Ceramics. Glass, TP785-869
Abstract: Abstract Thermal barrier coatings (TBCs) can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic top coat. However, the continuous pursuit of a higher operating temperature leads to degradation, delamination, and premature failure of the top coat. Both new ceramic materials and new coating structures must be developed to meet the demand for future advanced TBC systems. In this paper, the latest progress of some new ceramic materials is first reviewed. Then, a comprehensive spalling mechanism of the ceramic top coat is summarized to understand the dependence of lifetime on various factors such as oxidation scale growth, ceramic sintering, erosion, and calcium-magnesium-aluminium-silicate (CMAS) molten salt corrosion. Finally, new structural design methods for high-performance TBCs are discussed from the perspectives of lamellar, columnar, and nanostructure inclusions. The latest developments of ceramic top coat will be presented in terms of material selection, structural design, and failure mechanism, and the comprehensive guidance will be provided for the development of next-generation advanced TBCs with higher temperature resistance, better thermal insulation, and longer lifetime.
Published: 2022
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46. Novel aluminum-based fuel: Facile preparation to improve thermal reactions

Author: Guan, Fa-yang, Ren, Hui, Zhao, Wan-jun, Wu, Xin-zhou, and Jiao, Qing-jie
Published: 2022
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47. Editorial: Immunomodulatory role of metalloproteases in chronic inflammatory diseases

Author: Guan-Jun Yang, Dan Li, Chung Nga Ko, Shicheng Guo, and Chao Yang
Subjects: metalloproteases, immunomodulation, chronic inflammatory diseases, MMPs, ADAMs, Immunologic diseases. Allergy, RC581-607
Published: 2023
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48. The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential

Author: Ming-Hui Zhu, Yan-Jun Liu, Chang-Yun Li, Fan Tao, Guan-Jun Yang, and Jiong Chen
Subjects: LECT2, LECT2 receptor, immune regulation, inflammation-related diseases, comparative immunology, Immunologic diseases. Allergy, RC581-607
Abstract: Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in diverse physiological and pathological processes. The high sequence similarity of LECT2 among different vertebrates makes it possible to explore its functions by using comparative biology. LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types. In addition, the misfolding LECT2 leads to the amyloidosis of several crucial tissues (kidney, liver, and lung, etc.) by inducing the formation of insoluble fibrils. However, the mechanisms of LECT2-mediated diverse immune pathogenic conditions in various tissues remain to be fully elucidated due to the functional and signaling heterogeneity. Here, we provide a comprehensive summary of the structure, the “double-edged sword” function, and the extensive signaling pathways of LECT2 in immune diseases, as well as the potential applications of LECT2 in therapeutic interventions in preclinical or clinical trials. This review provides an integrated perspective on the current understanding of how LECT2 is associated with immune diseases, with the aim of facilitating the development of drugs or probes against LECT2 for the theranostics of immune-related diseases.
Published: 2023
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49. Effect of Lactobacillus plantarum LP104 on hyperlipidemia in high-fat diet induced C57BL/6N mice via alteration of intestinal microbiota

Author: Teng, Yue, Wang, Yu, Guan, Wu-yang, Wang, Chao, Yu, Han-song, Li, Xia, and Wang, Yu-hua
Published: 2022
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50. Effects of different concentrations of intraluminal sodium chloride solution on intracavitary ECG used for arm infusion port implantation

Author: Dong, Lei, Guan, Chen-yang, Zhang, Ying, Wang, Ai-xia, Liu, Ming-hua, Guo, Chen, Hao, Xiao-li, and Zhang, Qi
Published: 2022
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