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Introduction: The effects of denosumab on bone mineral density (BMD) and metabolism in patients with end‐stage renal disease (ESRD) remain controversial. Hence, we performed a systematic review and meta‐analysis of observational studies. Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched in June 2022 to identify studies that evaluated the risk of denosumab‐associated hypocalcemia and changes in bone metabolism, changes in BMD from baseline to post‐treatment in patients with ESRD. Findings: Twelve studies with 348 participants were included. The pooled incidence of hypocalcemia during denosumab treatment was 35.0% (95% confidence interval [CI], 25%–46%; I2 = 63.6%). There were no significant changes in either the serum calcium or phosphate levels from the baseline to post‐treatment period; the mean differences were 0.04 mg/dL (95% CI, −0.12 to 0.20 mg/dL) and −0.39 mg/dL (95% CI, −0.89 to 0.12 mg/dL). We found significant changes in the alkaline phosphatase and parathyroid hormone levels; the standardized mean differences were −2.98 (95% CI, −5.36 to –0.59) and −3.12 (95% CI: –4.94 to –1.29), respectively. Denosumab may increase BMD, with mean differences of 9.10% (95% CI: 4.07%–14.13%) and 9.00% (95% CI: 5.93%–12.07%) for the femoral neck and lumbar spine, respectively. Discussion: Denosumab increased the BMDs of the lumbar spine and femoral neck in patients with ESRD. The onset of hypocalcemia must be carefully monitored during denosumab administration. [ABSTRACT FROM AUTHOR]

Extensive fires pose catastrophic threats to both human and natural ecosystems. Understanding the history of fire, particularly Holocene palaeofire activity in densely populated areas, is essential for predicting future fire risks and developing effective fire management policies. The complexity of fire activity is influenced by various factors, including climate and anthropogenic activities. In this study, we analysed microcharcoal from the top 35.36 m of a well‐dated sediment core HMD1401 in Ningshao Plain, eastern China. We combined our findings with phytolith and diatom evidence to obtain a comprehensive understanding of variations in Holocene fire activity and its controls. The results showed that there was higher fire activity during the early and late Holocene and less fire activity during the mid‐Holocene. More frequent fire occurred from c. 10 000–7000 cal. a BP and was primarily caused by abundant biomass and high seasonal flammability due to increased annual temperature and precipitation and warm but dry winter climate. Fire occurrences between c. 7000–2000 cal. a BP remained at a low level, except for the periods c. 5900–5600 cal. a BP and c. 5300 cal. a BP, which may have been caused by extreme climate events. The impact of fire caused by human activity was significantly enhanced during the last two millennia. [ABSTRACT FROM AUTHOR]

This article, titled "[Retracted] Liraglutide protects renal mesangial cells against hyperglycemia-mediated mitochondrial apoptosis by activating the ERK-Yap signaling pathway and upregulating Sirt3 expression," was published in Molecular Medicine Reports in 2019. However, it has since been retracted due to concerns raised by a reader. The TUNEL assay data presented in Figures 1C and 5H were found to be similar to data published in other articles by different authors at different research institutes. The authors were asked for an explanation but did not respond. The editor apologizes for any inconvenience caused. [Extracted from the article]

Reliable information on the dynamics of hydrological changes is crucial for the social and economic stabilities and sustaining developments in arid Central Asia. However, the few long‐term hydrological records limit understanding of the relationship between meltwater runoff and climate changes, because the short‐term observations show a paradoxical runoff trend with climate warming across Central Asia. Here, we made a systematic analysis on the 10Be exposure ages of the river terraces developed in the eastern Tarim Basin and reconstructed the hydrological regime changes during the past 170 ka. These data, together with the ages of the river terraces in the water source areas, suggest that the exposure ages of river terraces in the eastern Tarim Basin reflect the depositional time of alluvial sediments. The meltwater runoff displays an inverse relation with the North Hemisphere Summer Insolation and temperature changes on both orbital and millennial time scale, indicating that low temperatures favor high runoff fluxes. The observed correlation between the hydrological regimes and temperature changes suggests that the runoff will decrease and thus climate will become drying with global warming in arid Central Asia. Plain Language Summary: Reliable information on the dynamics of hydrological changes is crucial for the social and economic stabilities and sustaining developments in arid Central Asia. However, the short‐term observations show a paradoxical runoff trend with climate warming across Central Asia. In order to understand the association of hydrological regimes with climate changes in arid Central Asia, particularly the hydrological changes on the context of global warming, this study reconstructs the hydrological changes in the eastern Tarim Basin over the past 170 ka. Our results show that the high runoff occurred during low temperature periods in the past. The inverse correlation between the hydrological regimes and temperatures in this study indicates that the runoff will decrease and climate will become drying with global warming in the future. More conservative water management policies should be taken for the sustaining development and water security in Central Asia. Key Points: 10Be exposure ages of river terraces in the eastern Tarim Basin reflect the depositional dates of alluvial sedimentsThe runoff in central Asia displays an inverse relation with global temperature changesHigh runoffs and humid climates occurred during cold periods over the past 170 ka, indicating a climate drying with global warming [ABSTRACT FROM AUTHOR]