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2. Applications of Direct Analysis in Real-Time Mass Spectrometry in Traditional Chinese Medicines Analysis

Author

WANG Xing-yu, GU Wen-yi, ZHANG Fang-li, ZHANG Dan, LI Lin-nan, WANG Zheng-tao1, and YANG Li1

Subjects
ambient mass spectrometry, direct analysis in real-time mass spectrometry (dart-ms), traditional chinese medicines, natural medicines, quality control, Chemistry, QD1-999
Abstract

Direct analysis in real-time mass spectrometry (DART-MS) is an emerging in-situ ionization mass spectrometry analysis technology in recent years. DART is a non-contact surface desorption ionization technique, which is based on the principle of using helium or nitrogen as the working gas and generating excited high-energy particles by electric discharge. The excited state particles are accelerated by rapid heating and electric force, which instantly ionize the volatile compounds on the surface of the sample to be measured under atmospheric pressure, and then detected by mass spectrometry, thus achieving real-time direct analysis of the sample. DART-MS has the characteristics of simple sample preparation, quick and in-situ analysis. Since DART-MS was reported in 2005, it has become one of the most broadly used direct analysis methods and is extensively applied for the direct analysis of the quality, safety, origin and characteristics of food samples. Besides, it has been widely used in biomedicine, environmental monitoring, public safety, and drug analysis as well. Traditional Chinese medicines (TCMs) have been used for thousands of years in China, which gradually move towards to the world arena. The composition of TCM is very complicated, often containing many different chemical components of different types and properties, such as flavonoids, alkaloids, terpenoids, etc. Therefore, the analysis of the chemical basis of the efficacy and quality evaluation of TCMs are very crucial. In recent years, the development of DART-MS technology has provided many new opportunities for direct and rapid analysis of active ingredients in TCMs. The review was focused on the applications of DART-MS in TCMs, which covered the principle, characteristics, influencing factors and technological progress of DART-MS technology, and systematically summarized the research and application of this technology in TCMs, including qualitative and quantitative analysis. In addition, this review briefly introduced the progress of the application of DART-MS in combination with other techniques, such as thin-layer chromatography, imaging mass spectrometry and solid-phase microextraction in the profiling of TCMs, and provided further perspectives on its application development.

Published
2023
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3. Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

Author

Zhang, Yuan-Yao, primary, Luo, Sen, additional, Li, Hai, additional, Sun, Shu-Ning, additional, Wang, Xian-Bo, additional, Zheng, Xin, additional, Huang, Yan, additional, Li, Bei-Ling, additional, Gao, Yan-Hang, additional, Qian, Zhi-Ping, additional, Liu, Feng, additional, Lu, Xiao-Bo, additional, Liu, Jun-Ping, additional, Ren, Hao-Tang, additional, Zheng, Yu-Bao, additional, Yan, Hua-Dong, additional, Deng, Guo-Hong, additional, Qiao, Liang, additional, Zhang, Yan, additional, Gu, Wen-Yi, additional, Xiang, Xiao-Mei, additional, Zhou, Yi, additional, Hou, Yi-Xin, additional, Zhang, Qun, additional, Xiong, Yan, additional, Zou, Cong-Cong, additional, Chen, Jun, additional, Huang, Ze-Bing, additional, Jiang, Xiu-Hua, additional, Qi, Ting-Ting, additional, Chen, Yuan-Yuan, additional, Gao, Na, additional, Liu, Chun-Yan, additional, Yuan, Wei, additional, Mei, Xue, additional, Li, Jing, additional, Li, Tao, additional, Zheng, Rong-Jiong, additional, Zhou, Xin-Yi, additional, Zhao, Jun, additional, and Meng, Zhong-Ji, additional

Published
2024
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4. Prevalence and Clinical Significance of Portal Vein Thrombosis in Patients With Cirrhosis and Acute Decompensation

Author

Zhang, Yan, Xu, Bao-yan, Wang, Xian-bo, Zheng, Xin, Huang, Yan, Chen, Jinjun, Meng, Zhong-ji, Gao, Yan-hang, Qian, Zhi-ping, Liu, Feng, Lu, Xiao-bo, Shi, Yu, Shang, Jia, Li, Hai, Wang, Shao-yang, Yin, Shan, Sun, Shu-ning, Hou, Yi-Xin, Xiong, Yan, Chen, Jun, Li, Bei-ling, Lei, Qing, Gao, Na, Ji, Liu-juan, Li, Jing, Jie, Fang-rong, Zhao, Rui-hong, Liu, Jun-ping, Lin, Tao-fa, Chen, Liu-ying, Tan, Wen-ting, Zhang, Qun, Zou, Cong-cong, Huang, Ze-bing, Jiang, Xiu-hua, Luo, Sen, Liu, Chun-yan, Zhang, Yu-yi, Li, Tao, Ren, Hao-tang, Wang, Shi-jin, Deng, Guo-hong, Xiong, Shu-e, Liu, Xiao-xiao, Wang, Chen, Yuan, Wei, Gu, Wen-yi, Qiao, Liang, Wang, Tong-yu, Wu, Dan-dan, Dong, Fu-chen, and Hua, Jing

Published
2020
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9. Insight into Hepatocellular Carcinogenesis at Transcriptome Level by Comparing Gene Expression Profiles of Hepatocellular Carcinoma with Those of Corresponding Noncancerous Liver

Author

Xu, Xiang-Ru, Huang, Jian, Xu, Zhi-Gang, Qian, Bin-Zhi, Zhu, Zhi-Dong, Yan, Qing, Cai, Ting, Zhang, Xin, Xiao, Hua-Sheng, Qu, Jian, Liu, Feng, Huang, Qiu-Hua, Cheng, Zhi-Hong, Li, Neng-Gan, Du, Jian-Jun, Hu, Wei, Shen, Kun-Tang, Lu, Gang, Fu, Gang, Zhong, Ming, Xu, Shu-Hua, Gu, Wen-Yi, Huang, Wei, Zhao, Xin-Tai, Hu, Geng-Xi, Gu, Jian-Ren, Chen, Zhu, and Han, Ze-Guang

Published
2001

10. Cervical Screening by Pap Test and Visual Inspection Enabling Same-Day Biopsy in Low-Resource, High-Risk Communities

Author

Tao, Lin, Amanguli, A., Li, Feng, Wang, Ying Hong, Yang, Lan, Mohemaiti, Meiliguli, Zhao, Jin, Zou, Xiao Guang, Saimaiti, Abudukeyoumu, Abudu, Mirensha, Maimaiti, Mikairemu, Chen, Shi Yan, Abudukelimu, Ruxianguli, Maimaiti, Ayinuer, Li, Shu Gang, Zhang, Wei, Aizimu, Ayinuer, Yang, An Qiang, Wang, Ju, Pang, Li Juan, Cao, Yu Guang, Gu, Wen Yi, and Zhang, Wen Jie

Published
2018
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11. Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

Author

Shen, Zi-Xuan, primary, Wu, Dan-Dan, additional, Xia, Jie, additional, Wang, Xian-Bo, additional, Zheng, Xin, additional, Huang, Yan, additional, Li, Bei-Ling, additional, Meng, Zhong-Ji, additional, Gao, Yan-Hang, additional, Qian, Zhi-Ping, additional, Liu, Feng, additional, Lu, Xiao-Bo, additional, Shang, Jia, additional, Yan, Hua-Dong, additional, Zheng, Yu-Bao, additional, Gu, Wen-Yi, additional, Zhang, Yan, additional, Wei, Jian-Yi, additional, Tan, Wen-Ting, additional, Hou, Yi-Xin, additional, Zhang, Qun, additional, Xiong, Yan, additional, Zou, Cong-Cong, additional, Chen, Jun, additional, Huang, Ze-Bing, additional, Jiang, Xiu-Hua, additional, Luo, Sen, additional, Chen, Yuan-Yuan, additional, Gao, Na, additional, Liu, Chun-Yan, additional, Yuan, Wei, additional, Mei, Xue, additional, Li, Jing, additional, Li, Tao, additional, Zhou, Xin-Yi, additional, Deng, Guo-Hong, additional, Chen, Jin-Jun, additional, Ma, Xiong, additional, and Li, Hai, additional

Published
2022
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12. Molecular Imaging of Stem Cells: Tracking Survival, Biodistribution, Tumorigenicity, and Immunogenicity

Author

Eugene Gu, Wen-Yi Chen, Jay Gu, Paul Burridge, Joseph C. Wu

Subjects
Medicine
Abstract

Being able to self-renew and differentiate into virtually all cell types, both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have exciting therapeutic implications for myocardial infarction, neurodegenerative disease, diabetes, and other disorders involving irreversible cell loss. However, stem cell biology remains incompletely understood despite significant advances in the field. Inefficient stem cell differentiation, difficulty in verifying successful delivery to the target organ, and problems with engraftment all hamper the transition from laboratory animal studies to human clinical trials. Although traditional histopathological techniques have been the primary approach for ex vivo analysis of stem cell behavior, these postmortem examinations are unable to further elucidate the underlying mechanisms in real time and in vivo. Fortunately, the advent of molecular imaging has led to unprecedented progress in understanding the fundamental behavior of stem cells, including their survival, biodistribution, immunogenicity, and tumorigenicity in the targeted tissues of interest. This review summarizes various molecular imaging technologies and how they have advanced the current understanding of stem cell survival, biodistribution, immunogenicity, and tumorigenicity.

Published
2012

15. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

Author

Ren, Shuang-Xi, Fu, Gang, Jiang, Xiu-Gao, Zeng, Rong, Miao, You-Gang, Xu, Hai, Zhang, Yi-Xuan, Xiong, Hui, Lu, Gang, Lu, Ling-Feng, Jiang, Hong-Quan, Jia, Jia, Tu, Yue-Feng, Jiang, Ju-Xing, Gu, Wen-Yi, Zhang, Yue-Qing, Cai, Zhen, Sheng, Hai-Hui, Yin, Hai-Feng, Zhang, Yi, Zhu, Gen-Feng, Wan, Ma, Huang, Hong-Lei, Qian, Zhen, Wang, Sheng-Yue, Ma, Wei, Yao, Zhi-Jian, Shen, Yan, Qiang, Bo-Qin, Xia, Qi-Chang, Guo, Xiao-Kui, Danchin, Antoine, Saint Girons, Isabelle, Somerville, Ronald L., Wen, Yu-Mei, Shi, Man-Hua, Chen, Zhu, Xu, Jian-Guo, and Zhao, Guo-Ping

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Shuang-Xi Ren [1, 2, 3]; Gang Fu [1, 4, 3]; Xiu-Gao Jiang [5, 3]; Rong Zeng [2, 3]; You-Gang Miao [2]; Hai Xu [2]; Yi-Xuan Zhang [2]; Hui Xiong [...]

Published
2003
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16. Variceal bleeding has increased mortality compared to nonvariceal bleeding only in males

Author

Erasmus, Hans-Peter, primary, Bektas, Rukiye, additional, Orland, Katharina, additional, Trifonova, Svetlozara, additional, Gu, Wen-Yi, additional, Uschner, Frank Erhard, additional, Brol, Maximilian J., additional, Chang, Johannes, additional, Praktiknjo, Michael, additional, Strassburg, Christian P., additional, Trebicka, Jonel, additional, and Jansen, Christian, additional

Published
2020
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17. HLA-DR regulates macrophage phenotypic transformation and affects malignant behavior in esophageal squamous cell carcinoma

Author

Li, Jiang Fen, primary, Xie, Yu Fang, additional, Liang, Wei Hua, additional, Zhang, Hai Jun, additional, Wang, Xue Li, additional, Liu, Ji Hong, additional, Liu, Kai, additional, Jiang, Xian Li, additional, Jiang, Chen Hao, additional, Yuan, Xin, additional, Zhang, An Zhi, additional, Pang, Li Juan, additional, Cui, Xiao Bin, additional, Yang, Lan, additional, Liu, Chun Xia, additional, Gu, Wen Yi, additional, Li, Feng, additional, and Hu, Jian Ming, additional

Published
2020
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19. Acute-on-Chronic Liver Failure in China: Rationale for Developing a Patient Registry and Baseline Characteristics

Author

Gu, Wen-yi, primary, Xu, Bao-yan, additional, Zheng, Xin, additional, Chen, Jinjun, additional, Wang, Xian-bo, additional, Huang, Yan, additional, Gao, Yan-hang, additional, Meng, Zhong-ji, additional, Qian, Zhi-ping, additional, Liu, Feng, additional, Lu, Xiao-bo, additional, Shang, Jia, additional, Li, Hai, additional, Wang, Shao-yang, additional, and Sun, Xin, additional

Published
2018
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20. Laser capture microdissection for detecting the expression of epithelial-mesenchymal transition-related genes in epithelial and spindle cells of paraffin-embedded formalin-fixed biphasic synovial sarcoma

Author

Wang, Ning, primary, Liu, Zi-Han, additional, Zou, Hong, additional, Pang, Li-juan, additional, Gu, Wen-yi, additional, Hu, Jian-Ming, additional, Li, Dong-mei, additional, Zhao, Jin, additional, Zhang, Jun, additional, Liu, Chun-Xia, additional, Zhang, Wen-Jie, additional, Qi, Yan, additional, and Li, Feng, additional

Published
2018
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23. Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites

Author

Liu, Xia, primary, Zhao, Bo, additional, Zheng, Hua-Jun, additional, Hu, Yan, additional, Lu, Gang, additional, Yang, Chang-Qing, additional, Chen, Jie-Dan, additional, Chen, Jun-Jian, additional, Chen, Dian-Yang, additional, Zhang, Liang, additional, Zhou, Yan, additional, Wang, Ling-Jian, additional, Guo, Wang-Zhen, additional, Bai, Yu-Lin, additional, Ruan, Ju-Xin, additional, Shangguan, Xiao-Xia, additional, Mao, Ying-Bo, additional, Shan, Chun-Min, additional, Jiang, Jian-Ping, additional, Zhu, Yong-Qiang, additional, Jin, Lei, additional, Kang, Hui, additional, Chen, Shu-Ting, additional, He, Xu-Lin, additional, Wang, Rui, additional, Wang, Yue-Zhu, additional, Chen, Jie, additional, Wang, Li-Jun, additional, Yu, Shu-Ting, additional, Wang, Bi-Yun, additional, Wei, Jia, additional, Song, Si-Chao, additional, Lu, Xin-Yan, additional, Gao, Zheng-Chao, additional, Gu, Wen-Yi, additional, Deng, Xiao, additional, Ma, Dan, additional, Wang, Sen, additional, Liang, Wen-Hua, additional, Fang, Lei, additional, Cai, Cai-Ping, additional, Zhu, Xie-Fei, additional, Zhou, Bao-Liang, additional, Jeffrey Chen, Z., additional, Xu, Shu-Hua, additional, Zhang, Yu-Gao, additional, Wang, Sheng-Yue, additional, Zhang, Tian-Zhen, additional, Zhao, Guo-Ping, additional, and Chen, Xiao-Ya, additional

Published
2015
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24. Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer

Author

Yu, Xian-Jun, primary, Yang, Min-Jun, additional, Zhou, Bo, additional, Wang, Gui-Zhen, additional, Huang, Yun-Chao, additional, Wu, Li-Chuan, additional, Cheng, Xin, additional, Wen, Zhe-Sheng, additional, Huang, Jin-Yan, additional, Zhang, Yun-Dong, additional, Gao, Xiao-Hong, additional, Li, Gao-Feng, additional, He, Shui-Wang, additional, Gu, Zhao-Hui, additional, Ma, Liang, additional, Pan, Chun-Ming, additional, Wang, Ping, additional, Chen, Hao-Bin, additional, Hong, Zhi-Peng, additional, Wang, Xiao-Lu, additional, Mao, Wen-Jing, additional, Jin, Xiao-Long, additional, Kang, Hui, additional, Chen, Shu-Ting, additional, Zhu, Yong-Qiang, additional, Gu, Wen-Yi, additional, Liu, Zi, additional, Dong, Hui, additional, Tian, Lin-Wei, additional, Chen, Sai-Juan, additional, Cao, Yi, additional, Wang, Sheng-Yue, additional, and Zhou, Guang-Biao, additional

Published
2015
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25. Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population

Author

Cui, Xiao-Bin, primary, Chen, Yun-Zhao, additional, Pang, Xue-lian, additional, Liu, Wei, additional, Hu, Jian-Ming, additional, Li, Shu-Gang, additional, Yang, Lan, additional, Zhang, Wen-Jie, additional, Liu, Chun-xia, additional, Cao, Yu-wen, additional, Jiang, Jin-Fang, additional, Gu, Wen-Yi, additional, Pang, James, additional, Yang, Lei, additional, Yuan, Xiang-Lin, additional, Yu, Shi-Ying, additional, and Li, Feng, additional

Published
2013
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26. Comparative and functional genomic analyses of the pathogenicity of phytopathogenXanthomonas campestrispv.campestris

Author

Qian, Wei, primary, Jia, Yantao, additional, Ren, Shuang-Xi, additional, He, Yong-Qiang, additional, Feng, Jia-Xun, additional, Lu, Ling-Feng, additional, Sun, Qihong, additional, Ying, Ge, additional, Tang, Dong-Jie, additional, Tang, Hua, additional, Wu, Wei, additional, Hao, Pei, additional, Wang, Lifeng, additional, Jiang, Bo-Le, additional, Zeng, Shenyan, additional, Gu, Wen-Yi, additional, Lu, Gang, additional, Rong, Li, additional, Tian, Yingchuan, additional, Yao, Zhijian, additional, Fu, Gang, additional, Chen, Baoshan, additional, Fang, Rongxiang, additional, Qiang, Boqin, additional, Chen, Zhu, additional, Zhao, Guo-Ping, additional, Tang, Ji-Liang, additional, and He, Chaozu, additional

Published
2005
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27. Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris.

Author

Qian W, Jia Y, Ren SX, He YQ, Feng JX, Lu LF, Sun Q, Ying G, Tang DJ, Tang H, Wu W, Hao P, Wang L, Jiang BL, Zeng S, Gu WY, Lu G, Rong L, Tian Y, Yao Z, Fu G, Chen B, Fang R, Qiang B, Chen Z, Zhao GP, Tang JL, and He C

Subjects
Brassica genetics, Brassica microbiology, DNA Transposable Elements, Molecular Sequence Data, Mutagenesis, Insertional, Operator Regions, Genetic, Plant Diseases genetics, Sequence Analysis, DNA, Bacterial Proteins genetics, Genome, Bacterial, Virulence Factors genetics, Xanthomonas campestris genetics, Xanthomonas campestris pathogenicity
Abstract

Xanthomonas campestris pathovar campestris (Xcc) is the causative agent of crucifer black rot disease, which causes severe losses in agricultural yield world-wide. This bacterium is a model organism for studying plant-bacteria interactions. We sequenced the complete genome of Xcc 8004 (5,148,708 bp), which is highly conserved relative to that of Xcc ATCC 33913. Comparative genomics analysis indicated that, in addition to a significant genomic-scale rearrangement cross the replication axis between two IS1478 elements, loss and acquisition of blocks of genes, rather than point mutations, constitute the main genetic variation between the two Xcc strains. Screening of a high-density transposon insertional mutant library (16,512 clones) of Xcc 8004 against a host plant (Brassica oleraceae) identified 75 nonredundant, single-copy insertions in protein-coding sequences (CDSs) and intergenic regions. In addition to known virulence factors, full virulence was found to require several additional metabolic pathways and regulatory systems, such as fatty acid degradation, type IV secretion system, cell signaling, and amino acids and nucleotide metabolism. Among the identified pathogenicity-related genes, three of unknown function were found in Xcc 8004-specific chromosomal segments, revealing a direct correlation between genomic dynamics and Xcc virulence. The present combination of comparative and functional genomic analyses provides valuable information about the genetic basis of Xcc pathogenicity, which may offer novel insight toward the development of efficient methods for prevention of this important plant disease.

Published
2005
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