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A scalable optical convolutional neural network (SOCNN) based on free-space optics and Koehler illumination was proposed to address the limitations of the previous 4f correlator system. Unlike Abbe illumination, Koehler illumination provides more uniform illumination and reduces crosstalk. SOCNN allows for scaling up of the input array and the use of incoherent light sources. Hence, the problems associated with 4f correlator systems can be avoided. We analyzed the limitations in scaling the kernel size and parallel throughput and found that SOCNN can offer a multilayer convolutional neural network with massive optical parallelism.

Through a survey of rose diseases in the South Tropical Garden in Kunming, China,it was found that black spot was the most common and serious disease of rose cultivated in the open air there, with an incidence of more than 90%. In this study, fungus isolation was performed on leaf samples of five black spot susceptible varieties of rose from the South Tropical Garden by tissue isolation. 18 strains of fungus were initially obtained, and 7 of them were finally identified to cause black spot symptoms on healthy leaves of rose after verification by Koch's rule. By observing the morphology of colonies and spores, and constructing a phylogenetic tree by combining molecular biology and multiple genes, 2 pathogenic fungus were identified, namely, Alternaria alternata and Gnomoniopsis rosae. G. rosae was the first pathogenic fungi of rose black spot isolated and identified in this study. The results of this study can provide a reference base for further research and control of the black spot disease of rose in Kunming.

A scalable optical computer based on free-space optics was proposed to obtain optical parallelism in an artificial neural network. The combination of lens arrays, a spatial light modulator, and a large-diameter lens can distribute the weighted input light to multiple detectors, which can add light from multiple inputs to achieve a linear combination optical engine. The nonlinear part of the neural network can be processed using distributed electronics, as in smart pixels. The proposed design was realised in hardware with 2×2 inputs and 2×2 outputs, using light-emitting diodes, a liquid crystal display, lens arrays, and a detector array assembled in an optical cage system with subsidiary electronics. The feasibility of the constructed optical computer was demonstrated by achieving the expected results of NAND and NOR logics in parallel in the non-difference mode. A simple pattern-checking function in the difference mode was also shown. The proposed architecture has the potential for realising massive optical parallelism if large array components and high-speed electronics are used in the future.

The thoughts of the predecessors are indeed not very meaningful to survival, and it is tiresome to listen to them for a long time. But before you criticize, you must know that all kinds of academic ideas or ideas today are evolved and improved step by step through human thought. Perhaps the ideas of the predecessors are boring, but they may be the fundamental origin of some modern ideas.

Cryptococcus neoformans is a major etiological agent of fungal meningoencephalitis. The outcome of cryptococcosis depends on the complex interactions between the pathogenic fungus and host immunity. The understanding of how C. neoformans manipulates the host immune response through its pathogenic factors remains incomplete. In this study, we defined the roles of a previously uncharacterized protein, Csn1201, in cryptococcal fitness and host immunity. Use of both inhalational and intravenous mouse models demonstrated that the CSN1201 deletion significantly blocked the pulmonary infection and extrapulmonary dissemination of C. neoformans. The in vivo hypovirulent phenotype of the csn1201Δ mutant was attributed to a combination of multiple factors, including preferential dendritic cell accumulation, enhanced Th1 and Th17 immune responses, decreased intracellular survival inside macrophages, and attenuated blood–brain barrier transcytosis rather than exclusively to pathogenic fitness. The csn1201Δ mutant exhibited decreased tolerance to various stressors in vitro, along with reduced capsule production and enhanced cell wall thickness under host-relevant conditions, indicating that the CSN1201 deletion might promote the exposure of cell wall components and thus induce a protective immune response. Taken together, our results strongly support the importance of cryptococcal Csn1201 in pulmonary immune responses and disseminated infection.

Additional file 1: Table S1. The lethality assay of S. pullorum ATCC 13036 for 2-day-old chickens.

We performed a tolerance analysis of a photonic crystal (PC) substrate used in spectrometer-free photonic crystal enhanced microscopy (SFPCEM). SFPCEM is a simplified version of photonic crystal enhanced microscopy and is used for viewing nanoparticles without an expensive spectrometer or a scanning stage. We varied various structural parameters of the PC substrate and determined the change in its spectral behavior in order to find out the tolerance and sensitivity of its final performance to the parameters. We also analyzed the incident light angle dependency of the PC substrate, and in an SFPCEM observation of a nanoparticle, it caused the image of a nanoparticle to be stretched. The tolerance analysis may help to optimize the PC substrate for observing nanoparticles more clearly in SFPCEM and provides the permissible fabrication error boundary for reasonable performance.

We developed a microdisplay-based microscope projection photolithography (MDMPP) technique in which a liquid crystal (LC) microdisplay is used as a reconfigurable photomask for a microscope projector. The LC microdisplay provides a significant advantage in terms of cost and speed since patterns can be generated through software instead of redesigning and fabricating glass photomasks. The constructed MDMPP system could produce line patterns as narrow as 2.4 um, smaller than that specified by the diffraction limit, with the aid of a 4X objective lens. The achievement of a linewidth smaller than the theoretical limit may be ascribed to a combination of overexposure and the underetching effect, in addition to the good optical performance of the system. In a diffraction experiment performed with fabricated slits, the application of the MDMPP technique helped provide various patterns of the slits, demonstrating the potential usefulness of the MDMPP system in undergraduate optics courses. We expect that MDMPP can contribute to the field of physics education and various areas of research, such as chemistry and biology, in the future., Comment: 14 pages, 8 figures, 6 tables

A total of 60 three-way crossbred (Landrace, Duroc, and Yorkshire) pigs were divided into two groups (processed sulfur-fed pigs (SFPs) and nonprocessed sulfur-fed pigs, (NSFPs)) and used to determine the effect of supplementation with 3 g kg-1 processed sulfur on water-soluble precursors, free amino acids, and taste of meat using an electronic tongue, during refrigerated storage.; Results: Glycogen and glucose levels of SFP were significantly higher than in NSFPs. Glycogen levels decreased and glucose levels increased during storage (P < 0.001). The pH and moisture content of SFPs were higher than in NSFPs. Inosine of SFPs was higher than in NSFPs (P < 0.05). Hence, umami and richness tastes of SFPs were higher than in NSFPs and increased during storage. The total free amino acid content of both groups was not different, although it increased during storage (P < 0.001). The umami taste of water-soluble precursors was improved in meat derived from SFPs during refrigeration.; Conclusion: The storage time and dietary supplementation with processed sulfur increased the taste components of meat. Application of an electronic tongue system can be used to distinguish the taste characteristics of different types of pork, based on differential supplementation and aging. © 2018 Society of Chemical Industry.; © 2018 Society of Chemical Industry.

The objective of this study was to determine the effect of Allium hookeri supplementation with whey powder in pig diet on meat quality, oxidative stability and sensory characteristics of Longissimus dorsi muscle samples. A total of 60 pigs were randomly assigned into the following three groups (four replicate pens per group with five pigs per pen): CON group, basal diet; AH, dietary supplementation with 10 g A. hookeri/kg feed and AHW, dietary supplementation with 5 g A. hookeri/40 g whey powder/kg feed. Proximate composition of muscle sample was not significantly affected by A. hookeri supplementation. On average, the AHW group showed higher pH but less cooking loss than the CON group. However, the AH and AHW groups had lower (p