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5. Combined Therapy of Experimental Autoimmune Uveitis by a Dual-Drug Nanocomposite Formulation with Berberine and Dexamethasone

Author

Huang,Chang, Zhang,Zhutian, Gu,Jifeng, Li,Dan, Gao,Shunxiang, Zhang,Rong, Shi,Rong, Sun,Jianguo, Huang,Chang, Zhang,Zhutian, Gu,Jifeng, Li,Dan, Gao,Shunxiang, Zhang,Rong, Shi,Rong, and Sun,Jianguo

Abstract

Chang Huang,1,2,* Zhutian Zhang,1,2,* Jifeng Gu,3,* Dan Li,1,2 Shunxiang Gao,1,2 Rong Zhang,1,2 Rong Shi,4 Jianguo Sun1,2 1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200031, People’s Republic of China; 2NHC Key Laboratory of Myopia, Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, 200031, People’s Republic of China; 3Department of Pharmacy, Eye & ENT Hospital, Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, 200031, People’s Republic of China; 4Science and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianguo Sun, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, People’s Republic of China, Email jgsun@fudan.edu.cn Rong Shi, Science and Technology Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China, Email rongshi56@126.comPurpose: Autoimmune uveitis is a kind of sight-threatening ocular and systemic disorders. Recent treatments on autoimmune uveitis still remain many limitations due to extreme complexity and undetermined pathogenesis. In this study, a novel dual-drug nanocomposite formulation is developed to treat experimental autoimmune uveitis by a combined and sustained therapy method.Methods: The dual-drug nanocomposite formulation is constructed by integrating berberine (BBR)-loaded mesoporous silica nanoparticles (MSNs) into dexamethasone (DEX)-loaded thermogel (BBR@MSN-DEX@Gel). The BBR@MSN-DEX@Gel is characterized by transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectrometer and rheometer. The in vitro drug release profile, cytotoxicity and anti-inflamm

Published
2023

10. A core-shell structured polyacrylonitrile@poly(vinylidene fluoride-hexafluoro propylene) microfiber complex membrane as a separator by co-axial electrospinning

Author

Shuting Yang, Wenhao Ma, Yanhong Yin, Gu Jifeng, and Aili Wang

Subjects
business.product_category, Materials science, General Chemical Engineering, Polyacrylonitrile, 02 engineering and technology, General Chemistry, Polyethylene, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Electrospinning, 0104 chemical sciences, chemistry.chemical_compound, Membrane, Chemical engineering, chemistry, Microfiber, Thermal stability, 0210 nano-technology, business, Porosity, Separator (electricity)
Abstract

A novel and facile core–shell structured polyacrylonitrile@poly (vinylidene fluoride-hexafluoro propylene) (PAN@PVDF-HFP) microfiber complex membrane was designed and fabricated via co-axial electrospinning, which was used as a separator in lithium-ion batteries. Poly(vinylidene fluoride-co-hexafluoro propene) (PVDF-HFP) and polyacrylonitrile (PAN) were used as the shell (outer) layer and core (inner), respectively. Structure, surface morphology, porosity, and thermal properties of the core–shell structured microfiber membranes were investigated. Compared with the traditional commercial porous polyethylene (PE) separator, the PAN@PVDF-HFP microfiber complex membranes exhibited higher porosity, superior thermal stability, better electrolyte wettability and higher ionic conductivity. As a consequence, batteries assembled with the PAN@PVDF-HFP microfiber complex membrane display better cycling stability and superior rate performance compared to those with the PE separator.

Published
2018

15. A biaxial stretched β-isotactic polypropylene microporous membrane for lithium-ion batteries

Author

Gu Jifeng, Yanhong Yin, and Shuting Yang

Subjects
Polypropylene, Materials science, Polymers and Plastics, 02 engineering and technology, General Chemistry, Microporous material, Porosimetry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, Crystallinity, chemistry.chemical_compound, Differential scanning calorimetry, Membrane, chemistry, Ultimate tensile strength, Materials Chemistry, Composite material, 0210 nano-technology, Porosity
Abstract

In this article, microporous polypropylene (PP) membranes were produced with TMB-5 as β-crystal nucleating agent by biaxial stretching. Influences of different concentration of TMB-5 were studied using differential scanning calorimetry and X-ray diffraction. It was found that the highest crystallinity was reached when the nucleating agent content was 0.5 wt %. The effect of stretching temperature and stretching ratio on pore size distribution and porosity of the membranes were investigated by scanning electron microscopy and mercury porosimeter, respectively. And physical properties, such as tensile strength, permeability, and puncture resistance of the microporous membrane prepared at the optimized conditions, were evaluated. Compared with commercial PP separator membrane, the as-prepared microporous membrane shows similar uniform pore size distribution and exhibits slightly higher porosity and ionic conductivities. When used as lithium-ion separator, the experimental film shows more stable cycling performance than the commercial one. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 135, 45825.

Published
2017
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19. Development and Validation of a Sensitive LC–MS-MS Assay for the Quantification of Betulonic Acid in Rat Plasma.

Author

Gu, Jifeng, Ding, Guoqiang, Chen, Nianzu, and Zhang, Zhen

Subjects
*LIQUID chromatography-mass spectrometry, *LABORATORY rats, *SAPOGENINS, *BLOOD plasma, *ELECTROSPRAY ionization mass spectrometry, *PHARMACOKINETICS, *QUANTITATIVE research
Abstract

A rapid, sensitive and reliable liquid chromatography–tandem mass spectrometry method was developed and validated for the determination of betulonic acid in rat plasma. The plasma samples were prepared by protein precipitation. Chromatographic separation was achieved on an Agela MG-C18 analytical column (50 × 2.1 mm, 5 µm) using methanol–water–formic acid (80:20:0.1, v/v/v) as the mobile phase with a constant flow rate of 0.6 mL/min. Mass detection was conducted by electrospray ionization in positive ion multiple reaction monitoring mode. The calibration curves were linear over a concentration range of 3.00–3,000 ng/mL for the analyte. The intra-day and inter-day accuracy and precision were within the acceptable limits of ±15% at all concentrations. The method was successfully applied for the estimation of betulonic acid in rat plasma from a preclinical pharmacokinetics study. [ABSTRACT FROM AUTHOR]

Published
2014
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20. LC–MS-MS Determination and Pharmacokinetic Study of the Novel Anti-Tumor Candidate Drug TEOA in Rats.

Author

Gu, Jifeng, Ding, Guoqiang, Chen, Nianzu, and Zhang, Zhen

Subjects
*PHARMACOKINETICS, *SHIKIMIC acid, *LABORATORY mice, *TRITERPENOIDS, *LIQUID chromatography-mass spectrometry, TUMOR prevention
Abstract

2α, 3α, 24-Trihydroxyurs-12-en-28-oic acid (TEOA) is a prominent ursane-type triterpenoid isolated from the root of Actinidia deliciosa, which has numerous pharmacological activities. To date, there is no report on the pharmacokinetic characterization of TEOA in biological samples. A specific, sensitive and robust liquid chromatography–tandem mass spectrometry (LC–MS-MS) method is reported for the fast assay of TEOA in rat plasma. Plasma sample preparation was based on liquid–liquid extraction with ethyl acetate. The extracted samples were determined using LC–MS-MS coupled with an atmospheric-pressure chemical ionization source in multiple-reaction monitoring scan mode. Chromatographic separation was achieved on a C18 Capcell PAK UG120 column (100 × 4.6 mm, i.d., 5 µm) using an isocratic elution mode with a total running time of 2.8 min. The selected ion pairs m/z 471.3 → 203.1 for the analyte and m/z 309.2 → 163.1 for internal standard were monitored in positive ionization mode for MS-MS detection. This method has been fully validated and the results showed good linearity, precision, accuracy and recovery. A stability test was conducted under various sample preparation, analysis and storage conditions. The method was successfully applied for the pharmacokinetic study of TEOA in rat plasma after oral administration of 100 mg/kg TEOA. [ABSTRACT FROM PUBLISHER]

Published
2013

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