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2. Matched pair analysis to evaluate the impact of hospitalization during radiation therapy as an early marker of survival in head and neck cancer patients

Author

Han, Hye Ri, Hermann, Gregory M., Ma, Sung Jun, Iovoli, Austin J., Wooten, Kimberly E., Arshad, Hassan, Gupta, Vishal, McSpadden, Ryan P., Kuriakose, Moni A., Markiewicz, Michael R., Chan, Jon M., Platek, Mary E., Ray, Andrew D., Gu, Fangyi, Hicks, Wesley L., Jr, Repasky, Elizabeth A., and Singh, Anurag K.

Published
2020
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3. Association of Insomnia and Obstructive Sleep Apnea with Worse Oral Mucositis and Quality of Life in Head and Neck Cancer Patients Undergoing Radiation Therapy.

Author

Iovoli, Austin J., Smith, Kelsey, Yu, Han, Kluczynski, Melissa A., Jungquist, Carla R., Ray, Andrew D., Farrugia, Mark K., Gu, Fangyi, and Singh, Anurag K.

Subjects
STOMATITIS, RESEARCH funding, HEAD & neck cancer, INSOMNIA, QUESTIONNAIRES, CANCER patients, MANN Whitney U Test, DESCRIPTIVE statistics, FUNCTIONAL status, CANCER pain, QUALITY of life, SLEEP apnea syndromes, HEALTH outcome assessment, CANCER fatigue, SALIVA, DISEASE risk factors, DISEASE complications
Abstract

Simple Summary: Patients with head and neck cancer undergoing curative treatment with radiation therapy and chemotherapy often experience sleep disturbances that can affect pain and quality of life. We prospectively studied this patient population using sleep symptom questionnaires to assess the impact of sleep disturbances on patient-reported outcomes. We found that at baseline, 39% of patients had subthreshold or greater insomnia and 54% screened positive for OSA. Upon completion of radiation therapy, patients with these sleep disturbances had worse patient-reported quality of life and oral mucositis pain. These findings highlight the importance of managing sleep disturbances as a potential method to improve patient-reported outcomes for patients undergoing radiation therapy for head and neck cancer. Background: Patients with head and neck cancer (HNC) undergoing radiation therapy (RT) often experience sleep disturbances that may contribute to oral mucositis (OM) and quality of life (QOL). Methods: Patients with HNC treated with RT at a single institution were examined. Sleep questionnaires were given on the first day of RT to assess for insomnia and obstructive sleep apnea (OSA). Patient-reported QOL and oral mucositis were assessed during RT. Associations between insomnia and OSA with QOL were assessed using the Mann–Whitney U test. Linear mixed models assessed associations with OM. Results: Among 87 patients, 34 patients (39%) had subthreshold or greater insomnia and 47 patients (54%) screened positive for OSA. Upon RT completion, patients with subthreshold or greater insomnia had worse physical function (p = 0.005), fatigue (p = 0.01), insomnia (p < 0.001), and sticky saliva (p = 0.002). Patients screening positive for OSA had worse physical function (p = 0.01), sticky saliva (p = 0.02), fatigue (p = 0.007), insomnia (p = 0.009), and pain (p = 0.005). Upon linear mixed model evaluation, subthreshold or greater insomnia (p = 0.01) and positive OSA screen (p = 0.002) were associated with worse OM. Conclusion: Insomnia and OSA are highly prevalent in patients with HNC undergoing RT. These sleep disturbances are associated with worse QOL and OM during treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Supplementary Table 1 from Eighteen Insulin-like Growth Factor Pathway Genes, Circulating Levels of IGF-I and Its Binding Protein, and Risk of Prostate and Breast Cancer

Author

Gu, Fangyi, primary, Schumacher, Fredrick R., primary, Canzian, Federico, primary, Allen, Naomi E., primary, Albanes, Demetrius, primary, Berg, Christine D., primary, Berndt, Sonja I., primary, Boeing, Heiner, primary, Bueno-de-Mesquita, H. Bas, primary, Buring, Julie E., primary, Chabbert-Buffet, Nathalie, primary, Chanock, Stephen J., primary, Clavel-Chapelon, Françoise, primary, Dumeaux, Vanessa, primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Haiman, Christopher A., primary, Hankinson, Susan E., primary, Hayes, Richard B., primary, Henderson, Brian E., primary, Hunter, David J., primary, Hoover, Robert N., primary, Johansson, Mattias, primary, Key, Timothy J., primary, Khaw, Kay-Tee, primary, Kolonel, Laurence N., primary, Lagiou, Pagona, primary, Lee, I-Min, primary, LeMarchand, Loic, primary, Lund, Eiliv, primary, Ma, Jing, primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Rodriguez, Laudina, primary, Sacerdote, Carlotta, primary, Sánchez, Maria-José, primary, Stampfer, Meir J., primary, Stattin, Pär, primary, Stram, Daniel O., primary, Thomas, Gilles, primary, Thun, Michael J., primary, Tjønneland, Anne, primary, Trichopoulos, Dimitrios, primary, Tumino, Rosario, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie J., primary, Willett, Walter C., primary, Yeager, Meredith, primary, Zhang, Shumin M., primary, Kaaks, Rudolf, primary, Riboli, Elio, primary, Ziegler, Regina G., primary, and Kraft, Peter, primary

Published
2023
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12. Time to first cigarette and its impact on lung tumorigenesis

Author

Zhang, Tongwu, primary, Sang, Jian, additional, Caporaso, Neil, additional, Gu, Fangyi, additional, Hutchinson, Amy, additional, Consonni, Dario, additional, Pesatori, Angela C., additional, Homer, Robert, additional, Chanock, Stephen, additional, and Landi, Maria Teresa, additional

Published
2022
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14. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia

Author

Gu, Fangyi, Zhang, Han, Hyland, Paula L., Berndt, Sonja, Gapstur, Susan M., Wheeler, William, ELLIPSE consortium*, the, Amos, Christopher I., Bezieau, Stephane, Bickeböller, Heike, Brenner, Hermann, Brennan, Paul, Chang‐Claude, Jenny, Conti, David V, Doherty, Jennifer Anne, Gruber, Stephen B, Harrison, Tabitha A, Hayes, Richard B, Hoffmeister, Michael, Houlston, Richard S, Hung, Rayjean J., Jenkins, Mark A., Kraft, Peter, Lawrenson, Kate, McKay, James, Markt, Sarah, Mucci, Lorelei, Phelan, Catherine M., Qu, Conghui, Risch, Angela, Rossing, Mary Anne, Wichmann, H.‐Erich, Shi, Jianxin, Schernhammer, Eva, Yu, Kai, Landi, Maria Teresa, and Caporaso, Neil E.

Published
2017
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15. Response

Author

Gu, Fangyi, Wacholder, Sholom, Freedman, Neal D., Panagiotou, Orestis A., Reyes-Guzman, Carolyn, Bertazzi, Pier Alberto, and Caporaso, Neil E.

Published
2014
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17. Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers

Author

Li, Wen-Qing, Pfeiffer, Ruth M., Hyland, Paula L., Shi, Jianxin, Gu, Fangyi, Wang, Zhaoming, Bhattacharjee, Samsiddhi, Luo, Jun, Xiong, Xiaoqin, Yeager, Meredith, Deng, Xiang, Hu, Nan, Taylor, Philip R., Albanes, Demetrius, Caporaso, Neil E., Gapstur, Susan M., Amundadottir, Laufey, Chanock, Stephen J., Chatterjee, Nilanjan, Landi, Maria Teresa, Tucker, Margaret A., Goldstein, Alisa M., and Yang, Xiaohong R.

Published
2014
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19. Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa

Author

Gu, Fangyi, primary, Gomez, Eduardo Cortes, additional, Chen, Jianhong, additional, Buas, Matthew F., additional, Schlecht, Nicolas F., additional, Hulme, Karen, additional, Kulkarni, Shweta Vishwas, additional, Singh, Prashant K., additional, O’Connor, Richard, additional, Ambrosone, Christine B., additional, Singh, Anurag K., additional, and Wang, Jianmin, additional

Published
2021
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20. Matched pair analysis for comparison of survival outcome of alternative regimens to standard three-weekly cisplatin-based concurrent chemoradiation of head and neck cancer

Author

Han, Hye Ri, primary, Ma, Sung Jun, additional, Hermann, Gregory M., additional, Iovoli, Austin J., additional, Wooten, Kimberly E., additional, Arshad, Hassan, additional, Gupta, Vishal, additional, McSpadden, Ryan P., additional, Kuriakose, Moni A., additional, Markiewicz, Michael R., additional, Chan, Jon M., additional, Platek, Mary E., additional, Ray, Andrew D., additional, Gu, Fangyi, additional, Hicks Jr, Wesley L., additional, and Singh, Anurag K., additional

Published
2021
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21. Matched pair analysis to evaluate weight loss during radiation therapy for head and neck cancer as a prognostic factor for survival

Author

Han, Hye Ri, primary, Hermann, Gregory M., additional, Ma, Sung Jun, additional, Iovoli, Austin J., additional, Wooten, Kimberly E., additional, Arshad, Hassan, additional, Gupta, Vishal, additional, McSpadden, Ryan P., additional, Kuriakose, Moni A., additional, Markiewicz, Michael R., additional, Chan, Jon M., additional, Platek, Mary E., additional, Ray, Andrew D., additional, Gu, Fangyi, additional, Jr, Wesley L. Hicks, additional, and Singh, Anurag K., additional

Published
2021
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22. Change in Physical Performance Correlates with Decline in Quality of Life and Frailty Status in Head and Neck Cancer Patients Undergoing Radiation with and without Chemotherapy

Author

Farrugia, Mark, primary, Erickson, Kayleigh, additional, Wendel, Elizabeth, additional, Platek, Mary E., additional, Ji, Wenyan, additional, Attwood, Kristopher, additional, Ma, Sung Jun, additional, Gu, Fangyi, additional, Singh, Anurag K., additional, and Ray, Andrew D., additional

Published
2021
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23. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes

Author

Chen, Jingchun, Loukola, Anu, Gillespie, Nathan A, Peterson, Roseann, Jia, Peilin, Riley, Brien, Maes, Hermine, Dick, Daniella M, Kendler, Kenneth S, Damaj, M Imad, Miles, Michael F, Zhao, Zhongming, Li, Ming D, Vink, Jacqueline M, Minica, Camelia C, Willemsen, Gonneke, Boomsma, Dorret I, Qaiser, Beenish, Madden, Pamela A F, Korhonen, Tellervo, Jousilahti, Pekka, Hällfors, Jenni, Gelernter, Joel, Kranzler, Henry R, Sherva, Richard, Farrer, Lindsay, Maher, Brion, Vanyukov, Michael, Taylor, Michelle, Ware, Jenifer J, Munafò, Marcus R, Lutz, Sharon M, Hokanson, John E, Gu, Fangyi, Landi, Maria T, Caporaso, Neil E, Hancock, Dana B, Gaddis, Nathan C, Baker, Timothy B, Bierut, Laura J, Johnson, Eric O, Chenoweth, Meghan, Lerman, Caryn, Tyndale, Rachel, Kaprio, Jaakko, Chen, Xiangning, Chen, Jingchun, Loukola, Anu, Gillespie, Nathan A, Peterson, Roseann, Jia, Peilin, Riley, Brien, Maes, Hermine, Dick, Daniella M, Kendler, Kenneth S, Damaj, M Imad, Miles, Michael F, Zhao, Zhongming, Li, Ming D, Vink, Jacqueline M, Minica, Camelia C, Willemsen, Gonneke, Boomsma, Dorret I, Qaiser, Beenish, Madden, Pamela A F, Korhonen, Tellervo, Jousilahti, Pekka, Hällfors, Jenni, Gelernter, Joel, Kranzler, Henry R, Sherva, Richard, Farrer, Lindsay, Maher, Brion, Vanyukov, Michael, Taylor, Michelle, Ware, Jenifer J, Munafò, Marcus R, Lutz, Sharon M, Hokanson, John E, Gu, Fangyi, Landi, Maria T, Caporaso, Neil E, Hancock, Dana B, Gaddis, Nathan C, Baker, Timothy B, Bierut, Laura J, Johnson, Eric O, Chenoweth, Meghan, Lerman, Caryn, Tyndale, Rachel, Kaprio, Jaakko, and Chen, Xiangning

Abstract

INTRODUCTION: FTND (Fagerstrӧm test for nicotine dependence) and TTFC (time to smoke first cigarette in the morning) are common measures of nicotine dependence (ND). However, genome-wide meta-analysis for these phenotypes has not been reported.METHODS: Genome-wide meta-analyses for FTND (N = 19,431) and TTFC (N = 18,567) phenotypes were conducted for adult smokers of European ancestry from 14 independent cohorts.RESULTS: We found that SORBS2 on 4q35 (p = 4.05 × 10-8), BG182718 on 11q22 (p = 1.02 × 10-8), and AA333164 on 14q21 (p = 4.11 × 10-9) were associated with TTFC phenotype. We attempted replication of leading candidates with independent samples (FTND, N = 7010 and TTFC, N = 10 061), however, due to limited power of the replication samples, the replication of these new loci did not reach significance. In gene-based analyses, COPB2 was found associated with FTND phenotype, and TFCP2L1, RELN, and INO80C were associated with TTFC phenotype. In pathway and network analyses, we found that the interconnected interactions among the endocytosis, regulation of actin cytoskeleton, axon guidance, MAPK signaling, and chemokine signaling pathways were involved in ND.CONCLUSIONS: Our analyses identified several promising candidates for both FTND and TTFC phenotypes, and further verification of these candidates was necessary. Candidates supported by both FTND and TTFC (CHRNA4, THSD7B, RBFOX1, and ZNF804A) were associated with addiction to alcohol, cocaine, and heroin, and were associated with autism and schizophrenia. We also identified novel pathways involved in cigarette smoking. The pathway interactions highlighted the importance of receptor recycling and internalization in ND.IMPLICATIONS: Understanding the genetic architecture of cigarette smoking and ND is critical to develop effective prevention and treatment. Our study identified novel candidates and biological pathways involved in FTND and TTFC phenotypes, and this will facilitate furth

Published
2020
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24. Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)

Author

Tsilidis, Konstantinos K., Travis, Ruth C., Appleby, Paul N., Allen, Naomi E., Lindström, Sara, Albanes, Demetrius, Ziegler, Regina G., McCullough, Marjorie L., Siddiq, Afshan, Barricarte, Aurelio, Berndt, Sonja I., Bueno-de-Mesquita, Bas H., Chanock, Stephen J., Crawford, David E., Diver, Ryan W., Gapstur, Susan M., Giovannucci, Edward, Gu, Fangyi, Haiman, Christopher A., Hayes, Richard B., Hunter, David J., Johansson, Mattias, Kaaks, Rudolf, Kolonel, Laurence N., Kraft, Peter, Le Marchand, Loic, Overvad, Kim, Polidoro, Silvia, Riboli, Elio, Schumacher, Fredrick R., Stevens, Victoria L., Trichopoulos, Dimitrios, Virtamo, Jarmo, Willett, Walter C., and Key, Timothy J

Published
2013
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25. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population

Author

Li, Wen-Qing, Hu, Nan, Hyland, Paula L., Gao, Ying, Wang, Zhao-Ming, Yu, Kai, Su, Hua, Wang, Chao-Yu, Wang, Le-Min, Chanock, Stephen J., Burdett, Laurie, Ding, Ti, Qiao, You-Lin, Fan, Jin-Hu, Wang, Yuan, Xu, Yi, Shi, Jian-Xin, Gu, Fangyi, Wheeler, William, Xiong, Xiao-Qin, Giffen, Carol, Tucker, Margaret A., Dawsey, Sanford M., Freedman, Neal D., Abnet, Christian C., Goldstein, Alisa M., and Taylor, Philip R.

Published
2013
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26. Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers

Author

Hartz, Sarah M., Short, Susan E., Saccone, Nancy L., Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah H., Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Gubjartsson, Daniel, Hansel, Nadia N., Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikäinen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Rosenberger, Albert, Scheet, Paul, Shaffer, John R., Teumer, Alexander, Thompson, John R., Vink, Jacqueline M., Vogelzangs, Nicole, Wenzlaff, Angela S., Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven H., Balmforth, Anthony J., Baumeister, Sebastian E., Beaty, Terri, Bennett, Siiri, Bergen, Andrew W., Boyd, Heather A., Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M., Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, Alistair S., Hällfors, Jenni, Han, Shizhong, Hartmann, Annette M., Hayward, Caroline, Heikkilä, Kauko, Hewitt, John K., Hottenga, Jouke Jan, Jensen, Majken K., Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven J., Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven M., Mathias, Rasika A., McNeil, Daniel W., Medland, Sarah E., Montgomery, Grant W., Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin M., Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkársdóttir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Goncalo, Barnes, Kathleen, Bickeböller, Heike, Boerwinkle, Eric, Boomsma, Dorret I., Caporaso, Neil, Duan, Jubao, Edenberg, Howard J., Francks, Clyde, Gejman, Pablo V., Gelernter, Joel, Grabe, Hans Jörgen, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kähönen, Mika, Kendler, Kenneth S., Lehtimäki, Terho, Levinson, Douglas F., Marazita, Mary L., Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton D., Murray, Jeffrey C., Nöthen, Markus M., Penninx, Brenda W., Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan R., Schwartz, Ann G., Shete, Sanjay, Shi, Jianxin, Spitz, Margaret, Stefansson, Kari, Swan, Gary E., Thorgeirsson, Thorgeir, Völzke, Henry, Wei, Qingyi, Wichmann, H.-Erich, Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric O., Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria L., Stitzel, Jerry A., Weiss, Robert B., Kraft, Peter, and Bierut, Laura J.

Published
2012
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27. Daily Time of Radiation Treatment Is Associated with Subsequent Oral Mucositis Severity during Radiotherapy in Head and Neck Cancer Patients

Author

Gu, Fangyi, primary, Farrugia, Mark K., additional, Duncan, William D., additional, Feng, Yingdong, additional, Hutson, Alan D., additional, Schlecht, Nicolas F., additional, Repasky, Elizabeth A., additional, Antoch, Marina P., additional, Miller, Austin, additional, Platek, Alexis, additional, Platek, Mary E., additional, Iovoli, Austin J., additional, and Singh, Anurag K., additional

Published
2020
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28. Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis

Author

Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming-Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, Mckay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz-Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P. A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, Christiani, David C., Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming-Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, Mckay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz-Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P. A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, and Christiani, David C.

Abstract

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Published
2019
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29. Elevated platelet count appears to be causally associated with increased risk of lung cancer:A mendelian randomization analysis

Author

Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, McKay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P.A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., Van der Heijden, Erik H.F.M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, Christiani, David C., Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, McKay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P.A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., Van der Heijden, Erik H.F.M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, and Christiani, David C.

Abstract

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non–small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15–2.27; P ¼ 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27–7.06; P ¼ 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Published
2019

30. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes

Author

Chen, Jingchun, primary, Loukola, Anu, primary, Gillespie, Nathan A, primary, Peterson, Roseann, primary, Jia, Peilin, primary, Riley, Brien, primary, Maes, Hermine, primary, Dick, Daniella M, primary, Kendler, Kenneth S, primary, Damaj, M Imad, primary, Miles, Michael F, primary, Zhao, Zhongming, primary, Li, Ming D, primary, Vink, Jacqueline M, primary, Minica, Camelia C, primary, Willemsen, Gonneke, primary, Boomsma, Dorret I, primary, Qaiser, Beenish, primary, Madden, Pamela A F, primary, Korhonen, Tellervo, primary, Jousilahti, Pekka, primary, Hällfors, Jenni, primary, Gelernter, Joel, primary, Kranzler, Henry R, primary, Sherva, Richard, primary, Farrer, Lindsay, primary, Maher, Brion, primary, Vanyukov, Michael, primary, Taylor, Michelle, primary, Ware, Jenifer J, primary, Munafò, Marcus R, primary, Lutz, Sharon M, primary, Hokanson, John E, primary, Gu, Fangyi, primary, Landi, Maria T, primary, Caporaso, Neil E, primary, Hancock, Dana B, primary, Gaddis, Nathan C, primary, Baker, Timothy B, primary, Bierut, Laura J, primary, Johnson, Eric O, primary, Chenoweth, Meghan, primary, Lerman, Caryn, primary, Tyndale, Rachel, primary, Kaprio, Jaakko, primary, and Chen, Xiangning, primary

Published
2019
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32. Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Author

Zhu, Ying, primary, Wei, Yongyue, additional, Zhang, Ruyang, additional, Dong, Xuesi, additional, Shen, Sipeng, additional, Zhao, Yang, additional, Bai, Jianling, additional, Albanes, Demetrius, additional, Caporaso, Neil E., additional, Landi, Maria Teresa, additional, Zhu, Bin, additional, Chanock, Stephen J., additional, Gu, Fangyi, additional, Lam, Stephen, additional, Tsao, Ming-Sound, additional, Shepherd, Frances A., additional, Tardon, Adonina, additional, Fernández-Somoano, Ana, additional, Fernandez-Tardon, Guillermo, additional, Chen, Chu, additional, Barnett, Matthew J., additional, Doherty, Jennifer, additional, Bojesen, Stig E., additional, Johansson, Mattias, additional, Brennan, Paul, additional, McKay, James D., additional, Carreras-Torres, Robert, additional, Muley, Thomas, additional, Risch, Angela, additional, Wichmann, Heunz-Erich, additional, Bickeboeller, Heike, additional, Rosenberger, Albert, additional, Rennert, Gad, additional, Saliba, Walid, additional, Arnold, Susanne M., additional, Field, John K., additional, Davies, Michael P.A., additional, Marcus, Michael W., additional, Wu, Xifeng, additional, Ye, Yuanqing, additional, Le Marchand, Loic, additional, Wilkens, Lynne R., additional, Melander, Olle, additional, Manjer, Jonas, additional, Brunnström, Hans, additional, Hung, Rayjean J., additional, Liu, Geoffrey, additional, Brhane, Yonathan, additional, Kachuri, Linda, additional, Andrew, Angeline S., additional, Duell, Eric J., additional, Kiemeney, Lambertus A., additional, van der Heijden, Erik HFM, additional, Haugen, Aage, additional, Zienolddiny, Shanbeh, additional, Skaug, Vidar, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Woll, Penella J., additional, Cox, Angela, additional, Taylor, Fiona, additional, Teare, Dawn M., additional, Lazarus, Philip, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Houlston, Richard S., additional, McLaughlin, John, additional, Stevens, Victoria L., additional, Shen, Hongbing, additional, Hu, Zhibin, additional, Dai, Juncheng, additional, Amos, Christopher I., additional, Han, Younghun, additional, Zhu, Dakai, additional, Goodman, Gary E., additional, Chen, Feng, additional, and Christiani, David C., additional

Published
2019
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33. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Author

Consortium, Coffee and Caffeine Genetics, Cornelis, Marilyn C, Renstrom, Frida, Rasheed, Asif, Mason, Marc A, Zonderman, Alan B, Franke, Lude, Kristal, Bruce S, Consortium, International Parkinson’s Disease Genomics, Consortium, North American Brain Expression, Consortium, UK Brain Expression, Karjalainen, Juha, Reed, Danielle R, Ngwa, Julius S, Westra, Harm-Jan, Evans, Michele K, Saleheen, Danish, Harris, Tamara B, Dedoussis, George, Curhan, Gary, Stumvoll, Michael, Beilby, John, Pasquale, Louis R, Feenstra, Bjarke, Huikari, Ville, Bandinelli, Stefania, Ordovas, Jose M, Chan, Andrew T, Peters, Ulrike, Ohlsson, Claes, Gieger, Christian, Martin, Nicholas G, Waldenberger, Melanie, Siscovick, David S, Raitakari, Olli, Cavadino, Alana, Eriksson, Johan G, Mitchell, Paul, Hunter, David J, Kraft, Peter, Rimm, Eric B, Boomsma, Dorret I, Borecki, Ingrid B, Loos, Ruth Jf, Wareham, Nicholas J, Vollenweider, Peter, Nolte, Ilja M, Caporaso, Neil, Grabe, Hans Jörgen, Neuhouser, Marian L, Wolffenbuttel, Bruce Hr, Hu, Frank B, Hyppönen, Elina, Järvelin, Marjo-Riitta, Cupples, L Adrienne, Franks, Paul W, Ridker, Paul M, Teumer, Alexander, van Duijn, Cornelia M, Heiss, Gerardo, Metspalu, Andres, North, Kari E, Ingelsson, Erik, Nettleton, Jennifer A, van Dam, Rob M, Chasman, Daniel I, Nalls, Michael A, Plagnol, Vincent, Yu, Kai, Hernandez, Dena G, Sharma, Manu, Sheerin, Una-Marie, Saad, Mohamad, Simón-Sánchez, Javier, Schulte, Claudia, Lesage, Suzanne, Sveinbjörnsdóttir, Sigurlaug, Arepalli, Sampath, Barker, Roger, Marques-Vidal, Pedro, Ben-Shlomo, Yoav, Berendse, Henk W, Berg, Daniela, Bhatia, Kailash, de Bie, Rob M A, Biffi, Alessandro, Bloem, Bas, Bochdanovits, Zoltan, Bonin, Michael, Bras, M., Rawal, Rajesh, Brockmann, Kathrin, Brooks, Janet, Burn, David J, Charlesworth, Gavin, Chen, Honglei, Chinnery, Patrick F, Chong, Sean, Clarke, Carl E, Cookson, Mark R, Cooper, J Mark, Manichaikul, Ani, Corvol, Jean Christophe, Counsell, Carl, Damier, Philippe, Dartigues, Jean-François, Deloukas, Panos, Deuschl, Günther, Dexter, David T, van Dijk, Karin D, Dillman, Allissa, Durif, Frank, Byrne, Enda M, Wojczynski, Mary K, Dürr, Alexandra, Edkins, Sarah, Evans, Jonathan R, Foltynie, Thomas, Dong, Jing, Gardner, Michelle, Gibbs, J Raphael, Goate, Alison, Gray, Emma, Guerreiro, Rita, Vink, Jacqueline M, Harris, Clare, van Hilten, Jacobus J, Hofman, Albert, Hollenbeck, Albert, Holton, Janice, Hu, Michele, Huang, Xuemei, Hershey, Milton S, Wurster, Isabel, Mätzler, Walter, Zhao, Jing Hua, Hudson, Gavin, Hunt, Sarah E, Huttenlocher, Johanna, Illig, Thomas, München, Helmholtz Zentrum, Jónsson, Pálmi V, Lambert, Jean-Charles, Langford, Cordelia, Lees, Andrew, Lichtner, Peter, Burlutsky, George, Limousin, Patricia, Lopez, Grisel, Lorenz, Delia, McNeill, Alisdair, Moorby, Catriona, Moore, Matthew, Morris, Huw R, Morrison, Karen E, O' Sullivan, Sean S, Lahti, Jari, Pearson, Justin, Perlmutter, Joel S, Pétursson, Hjörvar, Pollak, Pierre, Potter, Simon, Ravina, Bernard, Revesz, Tamas, Riess, Olaf, Rivadeneira, Fernando, Rizzu, Patrizia, Mikkilä, Vera, Ryten, Mina, Sawcer, Stephen, Schapira, Anthony, Scheffer, Hans, Shaw, Karen, Sidransky, Ellen, Smith, Colin, Spencer, Chris C A, Stefánsson, Hreinn, Bettella, Francesco, Lemaitre, Rozenn N, Stockton, Joanna D, Strange, Amy, Talbot, Kevin, Tanner, M., Tashakkori-Ghanbaria, Avazeh, Tison, François, Trabzuni, Daniah, Traynor, Bryan J, Uitterlinden, André G, Velseboer, Daan, Eriksson, Joel, Vidailhet, Marie, Walker, Robert, van de Warrenburg, Bart, Wickremaratchi, Mirdhu, Williams, Nigel, Williams-Gray, Caroline H, Winder-Rhodes, Sophie, Stefánsson, Kári, Martinez, Maria, Sabatier, Paul, Musani, Solomon K, Wood, Nicholas W, Hardy, John, Heutink, Peter, Brice, Alexis, Gasser, Thomas, Singleton, Andrew B, Singleton, Andrew, Cookson, Mark, Hernandez, Dena, Tanaka, Toshiko, Nalls, Michael, Zonderman, Alan, Ferrucci, Luigi, Johnson, Robert, Longo, Dan, O'Brien, Richard, Traynor, Bryan, Troncoso, Juan, Esko, Tõnu, Geller, Frank, van der Brug, Marcel, Zielke, Ronald, Weale, Michael, Ramasamy, Adaikalavan, Box, P. O., Luan, Jian'an, Hui, Jennie, Mägi, Reedik, Dimitriou, Maria, Garcia, Melissa E, Ho, Weang-Kee, Wright, Margaret J, Rose, Lynda M, Magnusson, Patrik Ke, Pedersen, Nancy L, Couper, David, Oostra, Ben A, Ikram, Mohammad Arfan, Tiemeier, Henning W, Uitterlinden, Andre G, van Rooij, Frank Ja, Barroso, Inês, Johansson, Ingegerd, Ganna, Andrea, Xue, Luting, Kaakinen, Marika, Milani, Lili, Power, Chris, Snieder, Harold, Stolk, Ronald P, Baumeister, Sebastian E, Biffar, Reiner, Gu, Fangyi, Bastardot, François, Paynter, Nina, Kutalik, Zoltán, Jacobs, David R, Forouhi, Nita G, Mihailov, Evelin, Lind, Lars, Lindgren, Cecilia, Michaëlsson, Karl, Morris, Andrew, Jensen, Majken, Khaw, Kay-Tee, Monda, Keri L, Luben, Robert N, Wang, Jie Jin, Männistö, Satu, Perälä, Mia-Maria, Kähönen, Mika, Lehtimäki, Terho, Viikari, Jorma, Mozaffarian, Dariush, Mukamal, Kenneth, Psaty, Bruce M, Amin, Najaf, Döring, Angela, Heath, Andrew C, Montgomery, Grant W, Dahmen, Norbert, Carithers, Teresa, Tucker, Katherine L, Boyd, Heather A, Melbye, Mads, Treur, Jorien L, Fischer, Krista, Mellström, Dan, Hottenga, Jouke Jan, Prokopenko, Inga, Tönjes, Anke, Kanoni, Stavroula, Lorentzon, Mattias, Houston, Denise K, Liu, Yongmei, Danesh, John, Biological Psychology, Nutrition and Health, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, The, Coffee, Cornelis, MC, Byrne, Enda, Esko, Tonu, Nalls, MA, Hyppönen, Elina, Chasman, DI, The Coffee and Caffeine Genetics Consortium, International Parkinson's Disease Genomics Consortium (IPDGC), UK Brain Expression Consortium (UKBEC), North American Brain Expression Consortium (NABEC), Epidemiology, Surgery, Public Health, Cell biology, Hematology, Clinical Genetics, Internal Medicine, Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Center for Liver, Digestive and Metabolic Diseases (CLDM), Stem Cell Aging Leukemia and Lymphoma (SALL), ANS - Amsterdam Neuroscience, Neurology, Graduate School, Pediatric surgery, VU University medical center, NCA - neurodegeneration, Human genetics, NCA - Brain mechanisms in health and disease, and NCA - Neurobiology of mental health

Subjects
INVOLVEMENT, Netherlands Twin Register (NTR), GCKR protein, human, PROTEIN, Genome-wide association study, VARIANTS, genetics [Brain-Derived Neurotrophic Factor], chemistry.chemical_compound, 0302 clinical medicine, Polymorphism (computer science), genetics [Adaptor Proteins, Signal Transducing], BINDING, BRAIN, Genetics, 0303 health sciences, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], 3. Good health, Psychiatry and Mental health, Phenotype, genetics [Polymorphism, Single Nucleotide], genetics [Cytochrome P-450 CYP1A2], Caffeine, CAFFEINE, Single-nucleotide polymorphism, Biology, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Cytochrome P-450 CYP1A2, SNP, Humans, ddc:610, Allele, genetics [Basic Helix-Loop-Helix Leucine Zipper Transcription Factors], Molecular Biology, 030304 developmental biology, Adaptor Proteins, Signal Transducing, MLXIPL protein, human, RECEPTOR, Brain-Derived Neurotrophic Factor, Coffea, ta1182, Feeding Behavior, biology.organism_classification, ta3124, BDNF, chemistry, Behavioral medicine, Developmental Psychopathology, 030217 neurology & neurosurgery, GLUCOKINASE, metabolism [Coffea], Genome-Wide Association Study
Abstract

Contains fulltext : 155360.pdf (Publisher’s version ) (Closed access) Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log10Bayes factor (BF)>5.64) with per-allele effect sizes of 0.03-0.14 cups per day. Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. Two map to GCKR and MLXIPL genes related to metabolic traits but lacking known roles in coffee consumption. Enhancer and promoter histone marks populate the regions of many confirmed loci and several potential regulatory SNPs are highly correlated with the lead SNP of each. SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme profiles (P

Published
2015
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34. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Author

Ji, Xuemei, Bosse, Yohan, Landi, Maria Teresa, Gui, Jiang, Xiao, Xiangjun, Qian, David, Joubert, Philippe, Lamontagne, Maxime, Li, Yafang, Gorlov, Ivan, de Biasi, Mariella, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Wu, Xifeng, Mckay, James, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeboeller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier A., Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Erik H. F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnstrom, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brueske, Irene, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Gu, Fangyi, Byun, Jinyoung, Kamal, Ahsan, Zhu, Dakai, Tyndale, Rachel F., Wei, Wei-Qi, Chanock, Stephen, Brennan, Paul, Amos, Christopher I., Ji, Xuemei, Bosse, Yohan, Landi, Maria Teresa, Gui, Jiang, Xiao, Xiangjun, Qian, David, Joubert, Philippe, Lamontagne, Maxime, Li, Yafang, Gorlov, Ivan, de Biasi, Mariella, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Wu, Xifeng, Mckay, James, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeboeller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier A., Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Erik H. F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnstrom, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brueske, Irene, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Gu, Fangyi, Byun, Jinyoung, Kamal, Ahsan, Zhu, Dakai, Tyndale, Rachel F., Wei, Wei-Qi, Chanock, Stephen, Brennan, Paul, and Amos, Christopher I.

Abstract

Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.

Published
2018
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35. Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma

Author

Gu, Fangyi, Chen, Ting-Huei, Pfeiffer, Ruth M, Fargnoli, Maria Concetta, Calista, Donato, Ghiorzo, Paola, Peris, Ketty, Puig, Susana, Menin, Chiara, De Nicolo, Arcangela, Rodolfo, Monica, Pellegrini, Cristina, Pastorino, Lorenza, Evangelou, Evangelo, Zhang, Tongwu, Hua, Xing, Dellavalle, Curt T, Timothy Bishop, D, Macgregor, Stuart, Iles, Mark I, Law, Matthew H, Cust, Anne, Brown, Kevin M, Stratigos, Alexander J, Nagore, Eduardo, Chanock, Stephen, Shi, Jianxin, Landi, Maria Teresa, Peris, Ketty (ORCID:0000-0002-5237-0463), Gu, Fangyi, Chen, Ting-Huei, Pfeiffer, Ruth M, Fargnoli, Maria Concetta, Calista, Donato, Ghiorzo, Paola, Peris, Ketty, Puig, Susana, Menin, Chiara, De Nicolo, Arcangela, Rodolfo, Monica, Pellegrini, Cristina, Pastorino, Lorenza, Evangelou, Evangelo, Zhang, Tongwu, Hua, Xing, Dellavalle, Curt T, Timothy Bishop, D, Macgregor, Stuart, Iles, Mark I, Law, Matthew H, Cust, Anne, Brown, Kevin M, Stratigos, Alexander J, Nagore, Eduardo, Chanock, Stephen, Shi, Jianxin, Landi, Maria Teresa, and Peris, Ketty (ORCID:0000-0002-5237-0463)

Published
2018

36. Nighttime eating and breast cancer among Chinese women in Hong Kong

Author

Li, Mengjie, Tse, Lap Ah, Chan, Wing-Cheong, Kwok, Chi-Hei, Leung, Siu-Lan, Wu, Cherry, Yu, Wai-Cho, Lee, Priscilla Ming-Yi, Tsang, Koon-Ho, Law, Sze-Hong, Vermeulen, Roel, Gu, Fangyi, Caporaso, Neil E, Yu, Ignatius Tak-Sun, Wang, Feng, Yang, Xiaohong Rose, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-2

Subjects
0301 basic medicine, Adult, Risk, medicine.medical_specialty, Food intake, Time Factors, Breast Neoplasms, Comorbidity, Logistic regression, Body Mass Index, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, Asian People, medicine, Odds Ratio, Humans, Eating habits, Aged, Medicine(all), Gynecology, Aged, 80 and over, business.industry, Nighttime eating behavior, Odds ratio, Feeding Behavior, Dietary factors, Middle Aged, medicine.disease, Confidence interval, Diet, 030104 developmental biology, 030220 oncology & carcinogenesis, Case-Control Studies, Population Surveillance, Eating behavior, Hong Kong, Female, business, Body mass index, Demography, Research Article
Abstract

Background A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits after 10 p.m. and breast cancer in Hong Kong women. Methods A hospital-based case-control study was conducted during 2012–2015. A total of 922 patients with incident breast cancer (cases) and 913 hospital controls were recruited and interviewed using a standard questionnaire including information on eating behavior during both daytime and nighttime. We collected the timing, duration, types and frequencies of food intake of eating at nighttime. Odds ratios (ORs) for the risk of breast cancer in relation to nighttime eating-related variables were calculated by unconditional multivariable logistic regression. Results Eating at night after 10 pm was significantly associated with breast cancer with an adjusted OR of 1.50 (95% confidence interval (CI) 1.06–2.12, P = 0.02), and the associations were stronger in women who had the longest duration of nighttime eating (≥20 years) (adjusted OR = 2.28 (95% CI 1.13–4.61, P = 0.02) and who ate late (midnight to 2 a.m.) (adjusted OR = 2.73, 95% CI 1.01–6.99, P = 0.04). Interestingly, nighttime eating was only associated with breast cancer among women who consumed staple foods (OR = 2.16, 95% CI 1.42–3.29, P

Published
2017

39. Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma

Author

Gu, Fangyi, primary, Chen, Ting-Huei, additional, Pfeiffer, Ruth M, additional, Fargnoli, Maria Concetta, additional, Calista, Donato, additional, Ghiorzo, Paola, additional, Peris, Ketty, additional, Puig, Susana, additional, Menin, Chiara, additional, De Nicolo, Arcangela, additional, Rodolfo, Monica, additional, Pellegrini, Cristina, additional, Pastorino, Lorenza, additional, Evangelou, Evangelos, additional, Zhang, Tongwu, additional, Hua, Xing, additional, DellaValle, Curt T, additional, Timothy Bishop, D, additional, MacGregor, Stuart, additional, Iles, Mark I, additional, Law, Matthew H, additional, Cust, Anne, additional, Brown, Kevin M, additional, Stratigos, Alexander J, additional, Nagore, Eduardo, additional, Chanock, Stephen, additional, Shi, Jianxin, additional, Consortium, Melanoma Meta-Analysis, additional, Consortium, MelaNostrum, additional, and Landi, Maria Teresa, additional

Published
2018
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40. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Author

Ji, Xuemei, primary, Bossé, Yohan, additional, Landi, Maria Teresa, additional, Gui, Jiang, additional, Xiao, Xiangjun, additional, Qian, David, additional, Joubert, Philippe, additional, Lamontagne, Maxime, additional, Li, Yafang, additional, Gorlov, Ivan, additional, de Biasi, Mariella, additional, Han, Younghun, additional, Gorlova, Olga, additional, Hung, Rayjean J., additional, Wu, Xifeng, additional, McKay, James, additional, Zong, Xuchen, additional, Carreras-Torres, Robert, additional, Christiani, David C., additional, Caporaso, Neil, additional, Johansson, Mattias, additional, Liu, Geoffrey, additional, Bojesen, Stig E., additional, Le Marchand, Loic, additional, Albanes, Demetrios, additional, Bickeböller, Heike, additional, Aldrich, Melinda C., additional, Bush, William S., additional, Tardon, Adonina, additional, Rennert, Gad, additional, Chen, Chu, additional, Teare, M. Dawn, additional, Field, John K., additional, Kiemeney, Lambertus A., additional, Lazarus, Philip, additional, Haugen, Aage, additional, Lam, Stephen, additional, Schabath, Matthew B., additional, Andrew, Angeline S., additional, Shen, Hongbing, additional, Hong, Yun-Chul, additional, Yuan, Jian-Min, additional, Bertazzi, Pier A., additional, Pesatori, Angela C., additional, Ye, Yuanqing, additional, Diao, Nancy, additional, Su, Li, additional, Zhang, Ruyang, additional, Brhane, Yonathan, additional, Leighl, Natasha, additional, Johansen, Jakob S., additional, Mellemgaard, Anders, additional, Saliba, Walid, additional, Haiman, Christopher, additional, Wilkens, Lynne, additional, Fernandez-Somoano, Ana, additional, Fernandez-Tardon, Guillermo, additional, van der Heijden, Erik H. F. M., additional, Kim, Jin Hee, additional, Dai, Juncheng, additional, Hu, Zhibin, additional, Davies, Michael P. A., additional, Marcus, Michael W., additional, Brunnström, Hans, additional, Manjer, Jonas, additional, Melander, Olle, additional, Muller, David C., additional, Overvad, Kim, additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, Doherty, Jennifer, additional, Goodman, Gary E., additional, Cox, Angela, additional, Taylor, Fiona, additional, Woll, Penella, additional, Brüske, Irene, additional, Manz, Judith, additional, Muley, Thomas, additional, Risch, Angela, additional, Rosenberger, Albert, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Shepherd, Frances, additional, Tsao, Ming-Sound, additional, Arnold, Susanne M., additional, Haura, Eric B., additional, Bolca, Ciprian, additional, Holcatova, Ivana, additional, Janout, Vladimir, additional, Kontic, Milica, additional, Lissowska, Jolanta, additional, Mukeria, Anush, additional, Ognjanovic, Simona, additional, Orlowski, Tadeusz M., additional, Scelo, Ghislaine, additional, Swiatkowska, Beata, additional, Zaridze, David, additional, Bakke, Per, additional, Skaug, Vidar, additional, Zienolddiny, Shanbeh, additional, Duell, Eric J., additional, Butler, Lesley M., additional, Koh, Woon-Puay, additional, Gao, Yu-Tang, additional, Houlston, Richard, additional, McLaughlin, John, additional, Stevens, Victoria, additional, Nickle, David C., additional, Obeidat, Ma’en, additional, Timens, Wim, additional, Zhu, Bin, additional, Song, Lei, additional, Artigas, María Soler, additional, Tobin, Martin D., additional, Wain, Louise V., additional, Gu, Fangyi, additional, Byun, Jinyoung, additional, Kamal, Ahsan, additional, Zhu, Dakai, additional, Tyndale, Rachel F., additional, Wei, Wei-Qi, additional, Chanock, Stephen, additional, Brennan, Paul, additional, and Amos, Christopher I., additional

Published
2018
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42. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Author

McKay, James D., Hung, Rayjean J., Han, Younghun, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil E., Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Byun, Jinyoung, Dunning, Alison, Pooley, Karen A., Qian, David C., Ji, Xuemei, Liu, Geoffrey, Timofeeva, Maria N., Bojesen, Stig E., Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher A., Wilkens, Lynne R., Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Henricus F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer A., Barnett, Matt P., Chen, Chu, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Manz, Judith, Muley, Thomas R., Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A., Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Joubert, Philippe, Lamontagne, Maxime, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Rafnar, Thorunn, Thorgeirsson, Thorgeir E., Reginsson, Gunnar W., Stefansson, Kari, Hancock, Dana B., Bierut, Laura J., Spitz, Margaret R., Gaddis, Nathan C., Lutz, Sharon M., Gu, Fangyi, Johnson, Eric O., Kamal, Ahsan, Pikielny, Claudio, Zhu, Dakai, Lindström, Sara, Jiang, Xia, Tyndale, Rachel F., Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa, Amos, Christopher I., McKay, James D., Hung, Rayjean J., Han, Younghun, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil E., Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Byun, Jinyoung, Dunning, Alison, Pooley, Karen A., Qian, David C., Ji, Xuemei, Liu, Geoffrey, Timofeeva, Maria N., Bojesen, Stig E., Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher A., Wilkens, Lynne R., Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Henricus F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer A., Barnett, Matt P., Chen, Chu, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Manz, Judith, Muley, Thomas R., Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A., Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Joubert, Philippe, Lamontagne, Maxime, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Rafnar, Thorunn, Thorgeirsson, Thorgeir E., Reginsson, Gunnar W., Stefansson, Kari, Hancock, Dana B., Bierut, Laura J., Spitz, Margaret R., Gaddis, Nathan C., Lutz, Sharon M., Gu, Fangyi, Johnson, Eric O., Kamal, Ahsan, Pikielny, Claudio, Zhu, Dakai, Lindström, Sara, Jiang, Xia, Tyndale, Rachel F., Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa, and Amos, Christopher I.

Abstract

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

Published
2017
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43. Nighttime eating and breast cancer among Chinese women in Hong Kong

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Li, Mengjie, Tse, Lap Ah, Chan, Wing-Cheong, Kwok, Chi-Hei, Leung, Siu-Lan, Wu, Cherry, Yu, Wai-Cho, Lee, Priscilla Ming-Yi, Tsang, Koon-Ho, Law, Sze-Hong, Vermeulen, Roel, Gu, Fangyi, Caporaso, Neil E, Yu, Ignatius Tak-Sun, Wang, Feng, Yang, Xiaohong Rose, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Li, Mengjie, Tse, Lap Ah, Chan, Wing-Cheong, Kwok, Chi-Hei, Leung, Siu-Lan, Wu, Cherry, Yu, Wai-Cho, Lee, Priscilla Ming-Yi, Tsang, Koon-Ho, Law, Sze-Hong, Vermeulen, Roel, Gu, Fangyi, Caporaso, Neil E, Yu, Ignatius Tak-Sun, Wang, Feng, and Yang, Xiaohong Rose

Published
2017

44. Identifying biomarkers of dietary patterns by using metabolomics123

Author

Playdon, Mary C, Moore, Steven C, Derkach, Andriy, Reedy, Jill, Subar, Amy F, Sampson, Joshua N, Albanes, Demetrius, Gu, Fangyi, Kontto, Jukka, Lassale, Camille, Liao, Linda M, Männistö, Satu, Mondul, Alison M, Weinstein, Stephanie J, Irwin, Melinda L, Mayne, Susan T, and Stolzenberg-Solomon, Rachael

Subjects
Nutritional Epidemiology and Public Health, Metabolomics, Biomarkers, Diet
Abstract

Background: Healthy dietary patterns that conform to national dietary guidelines are related to lower chronic disease incidence and longer life span. However, the precise mechanisms involved are unclear. Identifying biomarkers of dietary patterns may provide tools to validate diet quality measurement and determine underlying metabolic pathways influenced by diet quality.

Published
2016

47. Diurnal variation of metabolites in three individual participants.

Author

Gu, Fangyi, Klerman, Elizabeth B., Kim, Sungduk, Moore, Steve, Yu, Kai, Albert, Paul S., and Caporaso, Neil E

Subjects
*METABOLITES, *CIRCADIAN rhythms, *CHRONOBIOLOGY disorders, *METABOLOMICS, *METABOLITE analysis, *INDIVIDUAL differences
Abstract

The circadian system influences virtually all biological functions. Understanding the impact of circadian variation on metabolism may provide insight into mechanisms of circadian-associated disorders and guide the implementation of chrono-therapy. Previous research has reported circadian variation in 7-20% of metabolites in human blood. In this study, untargeted metabolomics profiles were measured using blood of two healthy men and one healthy woman, collected every 2 h for up to 48 h under carefully controlled conditions. The pattern of variation of each metabolite over time was examined on each participant separately, using both one- and two-order harmonic models. A total of 100 of 663 metabolites, representing all metabolite categories, showed diurnal rhythmic concentrations that exceeded the Bonferroni threshold (P < 2.5 × 10−5). Overall, peak times of many metabolites were clustered during the afternoon-midnight, including the majority of amino acids, all peptides, all lysolipids and all phospholipids, whereas the majority of steroids peaked in the morning. We observed substantial inter-individual variation for both peak times and amplitudes in these three subjects. In conclusion, at least 15% of blood metabolites, representing a broad group of biological pathways, exhibit diurnal variation in three participants. The average peak times of most of these metabolites are clustered in morning or afternoon-midnight. Further work is needed to validate and extend this work in more individuals. [ABSTRACT FROM AUTHOR]

Published
2019
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