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20 results on '"Gu, Anxin"'

9. Additional file 1 of The clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses

Author

Chen, Yungchang, Sun, Hao, Deng, Yanhong, Ma, Yutong, Huang, He, Liu, Yang, Zhang, Yaru, Zhang, Hongyu, Ye, Sheng, E, Mingyan, Guo, Hongqiang, Wu, Mengmeng, Wu, Chunman, Pu, Xingxiang, Chen, Xinggui, Liang, Chaoyong, Ou, Qiuxiang, Weng, Huawei, Wu, Xue, Shao, Yang, Gu, Anxin, and Lin, Tongyu

Abstract

Additional file 1: Supplementary Methods. Supplementary Table S1. Clinical characteristics of patients. Supplementary Figure S1. The overview of patients enrolled in this study and the concurrent gene/pathway alterations. (A) A total of 328 colorectal patients whose treatment-naïve tumor samples harboring BRAF mutations from the database are included in this study. (B) The oncoprint of the most frequently concurrent gene mutations (top panel) and pathway alterations (bottom panel) are shown as legend by BRAF classes. Supplementary Figure S2. Patients with Class 3 BRAF mutations demonstrated longer OS compared to those with Class1/2 BRAF mutations. Patients’ overall survival (OS) data from an additional external cohort were analyzed based on the Kaplan-Meier modeling. NR, not reached.

Published
2023
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20. [Mechanism and Research Progress of Microbiome in the Development of Lung Cancer].

Author

Liu G, Gu A, and E M

Subjects
Humans, Lung Neoplasms immunology, Lung Neoplasms metabolism, Lung Neoplasms pathology, Lung Neoplasms microbiology, Microbiota
Abstract

Lung cancer is one of the most common malignant tumors with poor prognosis in China, and most patients are diagnosed as advanced patients. Studies have shown that the microecological characteristics of lung cancer patients are different from healthy people, and the microorganisms of the respiratory tract can affect the occurrence and development of lung cancer through various mechanisms. In recent years, the study of the correlation between microbiome and disease has become another research hotspot following the Human Genome Project. However, at present, there are relatively few studies on the characteristics of lung cancer and respiratory microbiome. Therefore, it is necessary to further explore the potential relationship between lung cancer and microbial flora. By studying the mechanism of action of respiratory microorganisms in the development of lung cancer, it is expected to provide a clearer scientific basis in the clinical diagnosis, treatment and prognosis assessment of lung cancer. This article reviews the current researches on microbial flora and lung cancer, and provides new ideas for clinical diagnosis and treatment of lung cancer.
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Published
2020
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