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Background: The aim of the study was to examine the value of quantitative and qualitative MRI and 11 C acetate PET/CT parameters in predicting regional lymph node (LN) metastasis of newly diagnosed prostate cancer (PCa)., Patients and Methods: Patients with intermediate (n = 6) and high risk (n = 47) PCa underwent 3T MRI (40 patients) and 11 C acetate PET/CT (53 patients) before extended pelvic LN dissection. For each patient the visually most suspicious LN was assessed for mean apparent diffusion coefficient (ADCmean), maximal standardized uptake value (SUVmax), size and shape and the primary tumour for T stage on MRI and ADCmean and SUVmax in the index lesion. The variables were analysed in simple and multiple logistic regression analysis., Results: All variables, except ADCmean and SUVmax of the primary tumor, were independent predictors of LN metastasis. In multiple logistic regression analysis the best model was ADCmean in combintion with MRI T-stage where both were independent predictors of LN metastasis, this combination had an AUC of 0.81 which was higher than the AUC of 0.65 for LN ADCmean alone and the AUC of 0.69 for MRI T-stage alone., Conclusions: Several quantitative and qualitative imaging parameters are predictive of regional LN metastasis in PCa. The combination of ADCmean in lymph nodes and T-stage on MRI was the best model in multiple logistic regression with increased predictive value compared to lymph node ADCmean and T-stage on MRI alone., Competing Interests: Disclosure: Joel Kullberg and Håkan Ahlström are two of the founders of and employed by Antaros Medical AB. This company has not been involved in the presented study

Objectives: To evaluate the accuracy of the radiopharmaceutical [(11) C]-acetate combined with positron emission tomography/computer tomography (acetate-PET/CT) in lymph node (LN) staging in newly diagnosed prostate cancer cases. A second aim was to evaluate the potential discriminative properties of acetate-PET/CT in clinical routine., Patients and Methods: In a prospective comparative study, from July 2010 to June 2013, 53 men with newly histologically diagnosed intermediate- or high-risk prostate cancer underwent acetate-PET/CT investigation at one regional centre before laparoscopic extended pelvic LN dissection (ePLND) at one referral centre. The sensitivity, specificity and accuracy of acetate-PET/CT were calculated. Comparisons were made between true-positive and false-negative PET/CT cases to identify differences in the clinical parameters: PSA level, Gleason status, lymph metastasis burden and size, calculated risk of LN involvement, and curative treatment decisions., Results: In all, 26 patients had surgically/histologically confirmed LN metastasis (LN+). Acetate-PET/CT was true positive in 10 patients, false positive in one, false negative in 16, and true negative in 26. The individual sensitivity was 38%, specificity 96%, and accuracy 68%. The acetate-PET/CT positive cases had significantly more involved LNs (mean 7.9 vs 2.4, P < 0.001) with larger cancer diameters (14.1 vs 4.9 mm, P = 0.001) and fewer eventually had treatment with curative intent (40% vs 94%, P <0.005), although we lack long-term outcome data., Conclusion: Acetate-PET/CT has too low a sensitivity for routine LN staging but the specificity is high. The acetate-PET/CT positive cases have a very high burden of LN spread., (© 2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.)

It is significantly showed, that great infants have also in further life average a long body-height. From body-height at birth can be estimated the body-height-development. The great infants are great to time of school-absolvation. This also proves right for boys and girls.

The Authors inform about the degree of infection in children, which are born in Görlitz in 1957 to 1959. This study aimed at finding out, which infections still called "Classical children's diseases" should be particularly considered in childhood at present. The possibilitiy of vaccination against mumps and rubeolae in the GDR is discussed.

The different phases of increase of body-weight in boys and girls are studied. The development of body-weight from three anual-sets of children, who are born in the town of Görlitz, from birth to time of school-absolvation is presented.

The growth from birth till to last school-health-examination of 3 annual-sets (1957, 1958 and 1959) in the town of Goerlitz is presented. There are significant differences between the sexes. The growth of girls is more harmonious than that of boys. The growth rate in puberty in girls starts earlier and ends quicker. In boys the same phaenomenon begins later. The period of growth in boys is longer and produces a higher result.

Infants with higher birth-weight produce in further life more frequently an obesity. This also proves right for boys and girls. Sex differences appear not in early childhood but after beginning attendance at school.