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2. Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort
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Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, Isgett, S, Isidoro, T, Ismail, N, Ivulich, D, Jackson, C, Jelani, A, Joe, O, Joshi, S, Jung, A, Kaisbain, N, Kaleesvran, T, Ayadi Kamaluddin, M, Che Kamaruddin, Z, Kamarudin, N, Kang, K, Karpayah, P, Kartsonaki, C, Kay, C, Keating, S, Kelly, A, Kelly, S, Kennon, K, Khalid, I, Khan, I, Kho, M, Khoo, R, Khoo, D, Khoo, S, Kiat, K, Kida, Y, Kim, J, Kitamura, N, Klenerman, P, Knight, S, Kobbe, R, Krishnan, V, Kumar, D, Kumar, G, Kurtzman, E, Lalueza, A, Lanza, M, Law, A, Lee, T, Lee, H, Lee, B, Lee, Y, Lee, J, Leeming, G, Lene, H, Leone, M, Bassi, G, Lim, K, Lim, W, Lina, L, Liu, K, Loforte, A, Loon, L, Lopes, D, Low, L, Loy, J, Bermejo, C, Lunn, M, Lyons, R, Maasikas, O, Machado, S, de la Calle, G, Maier, L, Malfertheiner, M, Malik, N, Sant'ana Malaque, C, Marino, D, Marques, A, Marsh, B, Marsh, L, Marshall, J, Martin, E, Martinez, F, Martin-Loeches, I, Martins, J, Martins, A, Rego, C, Martucci, G, Marzukie, M, Maynar, J, Mcarthur, C, Mccanny, P, Mccloskey, C, Mcdermott, S, Mcdonald, S, Mcelroy, A, Mcelwee, S, Mcevoy, N, Mckay, C, Mckeown, J, Mclean, K, Mele, F, Menkiti, O, Mentzer, A, Mergler, B, Merson, L, Mesquita, A, Meynert, A, Mihnovit, V, Miller, J, Misnan, N, Mohamed, T, Eliza Mohamed, N, Moin, A, Mone, M, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Motos, A, Muh, N, Muhamad, D, Murphy, A, Murthy, S, Muyandy, G, Nagpal, D, Nagrebetsky, A, Neto, R, Neumann, E, Ng, W, Choileain, O, Nichol, A, Nitayavardhana, P, Nonas, S, Mohd Noordin, N, Izzati Norharizam, N, Norman, L, Noursadeghi, M, Occhipinti, G, O'Donnell, M, Ogura, T, Oliveira, J, Olliaro, P, Ong, J, Oosthuyzen, W, Openshaw, P, Ortoleva, J, Osatnik, J, Othman, S, Palmarini, M, Panarello, G, Panda, P, Pang, L, Panigada, M, Parke, R, Patauner, F, Pathmanathan, M, Patterson, L, Paulos, J, Paxton, W, Peake, S, Peariasamy, K, Jimenez, M, Pelosi, P, Pereira, R, Periel, L, Pesenti, A, Pimentel, C, Pires, C, Pius, R, Png, H, Poli, S, Pollakis, G, Post, A, Postma, D, Povoa, P, Povoas, D, Preiser, J, Pritchard, M, Proenca, L, Semedi, B, Quesada, L, Quinones-Cardona, V, Gonzalez, V, Quraishi, M, Rafael, A, Rahman, R, Rahman, A, Rajahram, G, Ramalho, J, Ramli, A, Ramos, G, Rangappa, R, Ratsep, I, Rau, C, Ravi, T, Reis, R, Rello, J, Ren, H, Richardson, D, Ahmad Ridzuan, S, Rios, A, Robba, C, Roberto, A, Roberts, S, Robertson, D, Rodeia, S, Roessler, B, Roger, C, Rojek, A, Roncon-Albuquerque, R, Rose, M, Rosenberger, D, Rossetti, M, Russell, C, Ryckaert, S, Saba, I, Sadat, M, Sakiyalak, P, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Santos, M, Satyapriya, S, Saviciute, E, Saw, Y, Schaffer, J, Schermer, T, Schwameis, M, Scott, J, Scott-Brown, J, Selvarajoo, M, Semple, M, Senian, R, Sequeira, F, Sequeira, T, Neto, A, Balazote, P, Shahidan, S, Shamsah, M, Sharma, P, Shaw, C, Shaw, V, Shetty, R, Shi, H, Shimizu, H, Shimizu, K, Shrapnel, S, Shum, H, Siang, N, Sigfrid, L, Sillaots, P, Silva, C, Heng, B, Singh, P, Singh, M, Sivam, K, Smith, S, Smood, B, Smyth, C, Snacken, M, Soh, T, Solomon, J, Solomon, T, Somers, E, Song, M, Sousa, M, Uva, M, Sperry, A, Sriskandan, S, Staudinger, T, Stecher, S, Stienstra, Y, Stolz, E, Stuart, A, Stuart, D, Suen, J, Summers, C, Suppiah, D, Syahrin, S, Sztajnbok, J, Szuldrzynski, K, Tabrizi, S, Taccone, F, Taib, S, Taleb, S, Talsma, J, Tan, K, Tan, Y, Tedder, R, Tee, T, Teixeira, J, Tejada, S, Teoh, S, Terpstra, P, Tessier-Grenier, H, Thabit, A, Tham, Z, Thangavelu, S, Thirumanickam, J, Thompson, S, Thomson, D, Thomson, E, Thorpe, M, Thurai, S, Thwaites, R, Toh, J, Tonnii, S, Torre, M, Torres, A, Towers, M, Trapani, T, Turtle, L, Udy, A, Ullrich, R, Uribe, A, Usman, A, Uyeki, T, Val-Flores, L, Van de Velde, S, Van Der Vekens, N, Van der Voort, P, Vanoverschelde, H, Vasudayan, S, Veeran, S, Ventura, S, Vidal, J, Vieira, C, Villanueva, J, Vitiello, C, Wahab, N, Wahab, S, Wahid, N, Wang, C, Webb, S, Wei, J, Wen, T, Wham, M, White, N, Wille, K, Williams, B, Williams, V, Williams, P, Wong, C, Wong, X, Wong, Y, Wong, T, Xian, G, Xian, L, Xuan, K, Mohd Yakop, S, Yamazaki, M, Yarad, E, Hing, N, Yeoh, C, Yerkovich, S, Yokoyama, T, Zaaqoq, A, Zahid, M, Binti Zaidan, N, Zambon, M, Zanella, A, Zaynah, N, Shah N., Xue B., Xu Z., Yang H., Marwali E., Dalton H., Payne P. P. R., Lu C., Said A. S., Abdukahil S. A., Abdulkadir N. N., Absil L., Acker A., Adriao D., Hssain A. A., Akwani C., Qasim E. A., Alalqam R., Al-Dabbous T., Alex B., Al-Fares A., Alfoudri H., Aliudin J., Alves J., Alves R., Alves J. M., Cabrita J. A., Amaral M., Amira N., Andini R., Anthonidass S., Antonelli M., Arabi Y., Arcadipane A., Arenz L., Arnold-Day C., Arora L., Arora R., Ashraf M., Asyraf A., Atique A., Bach B., Baillie J. K., Bak E., Bakar N. A., Balakrishnan M., Barbalho R., Barclay W. S., Barnett S. U., Barnikel M., Barrasa H., Barrigoto C., Baruch J., Hassin Basri M. F., Battaglini D., Bautista Rincon D. F., Bee K. H., Begum H., Beljantsev A., Benjiman L. E., Bento L., Bernal Sobrino J. L., Bertolino L., Bhatt A., Bianco C., Bidin F. N., Humaid F. B., Bin Kamarudin M. N., Blanco-Schweizer P., Bloos F., Boccia F., Bogaert D., Borges D., Bouhmani D., Bouziotis J., Boylan M., Bozza F. A., Brazzi L., Brewster D., Brickell K., Broadley T., Brozzi N., Buchtele N., Burrell A., Cabral S., Cabrita J., Garces R. C., Calligy K., Campbell P., Cardoso S., Cardoso F., Carelli S., Carrier F. M., Carson G., Cascao M., Casimiro J., Castanheira N., Castro I., Catarino A., Cavalin R., Cavalli G. G., Cavayas A., Chand M., Chen A., Chen Y. -S., Cheng M. P., Chica J., Chidambaram S. K., Tho L. C., Cho S. -M., Chow T. S., Chua H. J., Chua J., Cidade J. P., Citarella B. W., Ciullo A., Clarke J., Clohisey S., Codan C., Coles J., Colombo S. M., Connor M., Cooke G. S., Corley A., Cornelis S., Corpuz A. J., Crump J., Cruz C., Cruz Bermudez J. L., Rojo J. C., Csete M., Cullen A., Cummings M., Curley G., Custodio P., Filipe A. S., Dabaliz A. -A., Dagens A., Dahly D., Dalton J., Damas J., Dankwa E. A., Dantas J., de Loughry G., de Rosa R., de Silva T., Deacon J., Dean D., Debenedictis B., Dell'Amore A., Denis E., Depuydt P., Desai M., Dhangar P., Diaz R., Dieperink W., Docherty A. B., Doherty H., Donnelly C. A., Donohue C., Downer T., Drake T., Duculan T., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Ean S. C., Echeverria-Villalobos M., Elotmani L., Elshazly T., Eng C. C., Escher M., Santo C. E., Estevao J., Everding A. G., Fairfield C. J., Faria P., Fateena H., Fayed M., Fernandes J., Fernandes M. A., Fernandes S., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fiorda J., Fletcher T., Florio L. L., Fonseca T., Forsyth S., Foti G., Fowler R. A., Fraser J. F., Fraser C., Ribeiro A. F., French C., Fukuda M., G A., Gagliardi M., Gaiao S., Gamble C., Gani Y., Garcia R., Barrio N. G., Gavin A., Germano N., Giani M., Gilroy E., Girvan M., Gnall E., Goffard J. -C., Goh J. Y., Golob J., Gonzalez A., Graf J., Grasselli G., Green C. A., Greenhalf W., Grieco D. L., Griffee M., Griffiths F., Lordemann A. G., Gruner H., Gu Y., Guerreiro D., Castro M. G., Hakak S., Hall M., Halpin S., Hamer A., Hammond T., Hammond N., Han L. Y., Hao K. W., Hardwick H., Ekow Harrison S. B., Harrison E. M., Harrison J., Heerman J., Hendry R., Hennessy M., Higgins D., Higgins R., Hinton S., Ho Y. B., Ho A., Hoh W. H., Holt R., Horby P., Hsu J. M. -Y., Hurd A., Ijaz S., Inacio H., Ing Y. S., Isgett S., Isidoro T., Ismail N., Ivulich D., Jackson C., Jelani A. M., Joe O. Y., Joshi S., Jung A., Kaisbain N., Kaleesvran T., Ayadi Kamaluddin M. A., Che Kamaruddin Z. A., Kamarudin N., Kang K. Y., Karpayah P., Kartsonaki C., Kay C., Keating S., Kelly A., Kelly S., Kennon K., Khalid I., Khan I., Kho M. E., Khoo R., Khoo D., Khoo S., Kiat K. H., Kida Y., Kim J. B., Kitamura N., Klenerman P., Knight S. R., Kobbe R., Krishnan V., Kumar D., Kumar G., Kurtzman E., Lalueza A., Lanza M., Law A., Lee T. C., Lee H. G., Lee B. H., Lee Y. L., Lee J., Leeming G., Lene H. S., Leone M., Bassi G. L., Lim K. C., Lim W. S., Lina L., Liu K., Loforte A., Loon L. C., Lopes D., Low L. L., Loy J. S., Bermejo C. L., Lunn M., Lyons R., Maasikas O., Machado S., de la Calle G. M., Maier L. S., Malfertheiner M., Malik N., Sant'ana Malaque C. M., Marino D., Marques A., Marsh B., Marsh L., Marshall J., Martin E., Martinez F. E., Martin-Loeches I., Martins J., Martins A., Rego C. M., Martucci G., Marzukie M., Maynar J., McArthur C., McCanny P., McCloskey C., McDermott S., McDonald S. E., McElroy A., McElwee S., McEvoy N., McKay C., McKeown J., McLean K. A., Mele F., Menkiti O., Mentzer A. J., Mergler B., Merson L., Mesquita A., Meynert A. M., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Motos A., Muh N. Y., Muhamad D., Murphy A., Murthy S., Muyandy G., Nagpal D., Nagrebetsky A., Neto R., Neumann E., Ng W. Y., Choileain O. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Izzati Norharizam N. F., Norman L., Noursadeghi M., Occhipinti G., O'Donnell M., Ogura T., Oliveira J., Olliaro P. L., Ong J. Y., Oosthuyzen W., Openshaw P., Ortoleva J., Osatnik J., Othman S. Z., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Parke R., Patauner F., Pathmanathan M. D., Patterson L., Paulos J., Paxton W. A., Peake S. L., Peariasamy K., Jimenez M. P., Pelosi P., Pereira R., Periel L., Pesenti A., Pimentel C., Pires C., Pius R., Png H. S., Poli S., Pollakis G., Post A. -M., Postma D. F., Povoa P., Povoas D., Preiser J. -C., Pritchard M. G., Proenca L., Semedi B. P., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quraishi M., Rafael A., Rahman R. A., Rahman A. K. H. A., Rajahram G. S., Ramalho J., Ramli A. A., Ramos G. V., Rangappa R., Ratsep I., Rau C., Ravi T., Reis R., Rello J., Ren H., Richardson D., Ahmad Ridzuan S. N. A., Rios A. L., Robba C., Roberto A., Roberts S., Robertson D. L., Rodeia S., Roessler B., Roger C., Rojek A., Roncon-Albuquerque R., Rose M., Rosenberger D., Rossetti M., Russell C. D., Ryckaert S., Saba I., Sadat M., Sakiyalak P., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Santos M., Satyapriya S., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Schwameis M., Scott J. T., Scott-Brown J., Selvarajoo M., Semple M. G., Senian R. B., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shahidan S. A., Shamsah M., Sharma P., Shaw C. A., Shaw V., Shetty R. M., Shi H., Shimizu H., Shimizu K., Shrapnel S., Shum H. P., Siang N. Y., Sigfrid L., Sillaots P., Silva C., Heng B. S. L., Singh P., Singh M., Sivam K., Smith S., Smood B., Smyth C., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Song M. J., Sousa M., Uva M. S., Sperry A., Sriskandan S., Staudinger T., Stecher S. -S., Stienstra Y., Stolz E., Stuart A., Stuart D., Suen J. Y., Summers C., Suppiah D., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Taib S. M., Taleb S., Talsma J., Tan K. K., Tan Y. C., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Teoh S. K., Terpstra P., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thurai S. R. T., Thwaites R. S., Toh J. Z. Y., Tonnii S. L., Torre M., Torres A., Towers M., Trapani T., Turtle L. C. W., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Van de Velde S., Van Der Vekens N., Van der Voort P., Vanoverschelde H., Vasudayan S. R., Veeran S., Ventura S., Vidal J. E., Vieira C., Villanueva J. A., Vitiello C., Wahab N. H., Wahab S. A., Wahid N. A., Wang C. -H., Webb S., Wei J., Wen T. P., Wham M., White N., Wille K., Williams B., Williams V., Williams P. J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Xuan K. P., Mohd Yakop S. R. B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., Zaynah N., Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, 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B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., and Zaynah N.
- Abstract
Background: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a lifesaving support modality for severe respiratory failure, but its resource-intensive nature led to significant controversy surrounding its use during the COVID-19 pandemic. We report the performance of several ECMO mortality prediction and severity of illness scores at discriminating survival in a large COVID-19 V-V ECMO cohort. Methods: We validated ECMOnet, PRESET (PREdiction of Survival on ECMO Therapy-Score), Roch, SOFA (Sequential Organ Failure Assessment), APACHE II (acute physiology and chronic health evaluation), 4C (Coronavirus Clinical Characterisation Consortium), and CURB-65 (Confusion, Urea nitrogen, Respiratory Rate, Blood Pressure, age >65 years) scores on the ISARIC (International Severe Acute Respiratory and emerging Infection Consortium) database. We report discrimination via Area Under the Receiver Operative Curve (AUROC) and Area under the Precision Recall Curve (AURPC) and calibration via Brier score. Results: We included 1147 patients and scores were calculated on patients with sufficient variables. ECMO mortality scores had AUROC (0.58–0.62), AUPRC (0.62–0.74), and Brier score (0.286–0.303). Roch score had the highest accuracy (AUROC 0.62), precision (AUPRC 0.74) yet worst calibration (Brier score of 0.3) despite being calculated on the fewest patients (144). Severity of illness scores had AUROC (0.52–0.57), AURPC (0.59–0.64), and Brier Score (0.265–0.471). APACHE II had the highest accuracy (AUROC 0.58), precision (AUPRC 0.64), and best calibration (Brier score 0.26). Conclusion: Within a large international multicenter COVID-19 cohort, the evaluated ECMO mortality prediction and severity of illness scores demonstrated inconsistent discrimination and calibration highlighting the need for better clinically applicable decision support tools.
- Published
- 2023
3. Neurological manifestations of COVID-19 in adults and children
- Author
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O., Wille K., Willems S., Williams V., Wils E. -J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Hing N. Y. L., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke.
- Published
- 2023
4. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
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M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Mohamed N. N. E., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Morales Cely L., Moro L., Motherway C., Motos A., Mouquet H., Mouton Perrot C., Moyet J., Mudara C., Mufti A. K., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Murthy S., Musaab H., Muvindi H., Muyandy G., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nelwan E., Neto R., Neumann E., Ng P., Ng W. Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nusantara D. U., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Palacios M., Palacios A., Palmarini M., Panarello G., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Pasha T., Pasquier J., Pastene B., Patauner F., Patel D., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul M., Paul C., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pitaloka A., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Priyadarshani G. D. D., Proenca L., Pudota S., Puechal O., Semedi B. P., Pulicken M., Purcell G., Quesada L., Quinones-Cardona V., Quiros Gonzalez V., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahardjani M., Rahman R. A., Rahman A. K. H. A., Rahutullah A., Rainieri F., Rajahram G. S., Ramachandran P., Ramli A. A., Rammaert B., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehman A., Reid L., Reikvam D. H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes L. F., Reyes T., Ribeiro M. I., Ricchiuto A., Richardson D., Richier L., Ridzuan S. N. A. A., Riera J., Rios A. L., Rishu A., Rispal P., Risso K., Nunez M. A. R., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roilides E., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Roslan N. H. M., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Rusmawatiningtyas D., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadaf S., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Sales G., Sallaberry S., Salmon Gandonniere C., Salvator H., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satya A., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Schwartz G., Scicluna B., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semaille C., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Serpa Neto A., Serrano Balazote P., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Shaw C. A., Shaw V., Sheharyar A., Shetty R., Shetty R. M., Shi H., Shiban N., Shiekh M., Shime N., Shimizu H., Shimizu K., Shrapnel S., Shrestha P. S., Shrestha S. K., Shum H. P., Si Mohammed N., Siang N. Y., Sibiude J., Siddiqui A., Sillaots P., Silva C., Silva R., Silva M. J., Sin W. C., Sinatti D., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Sommet A., Song R., Song T., Song Chia J., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa M., Sousa A. C., Sousa Uva M., Souza-Dantas V., Sperry A., Spinuzza E., Sanka Ruwan Sri Darshana B. P., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Stuart D., Stuart A., Subekti D., Suen G., Suen J. Y., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Suwarti S., Svistunov A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taib S. M., Talarek E., Taleb S., Talsma J., Tamisier R., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Tanaka H., Taniguchi H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Thakur A., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson E. C., Thomson D., Thurai S. R. T., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toh J. Z. Y., Toki M., Tonby K., Tonnii S. L., Torres M., Torres A., Torres Santos-Olmo R. M., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Valentini P., Val-Flores L., Valran A., Van De Velde S., van Den Berge M., Van Der Feltz M., van Der Palen J., van Der Valk P., Van Der Vekens N., Van Der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Someren Greve F., van Veen I., Van Willigen H., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Vishwanathan G., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab S. A., Wahab N. H., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wong C., Wong Y. S., Wong T. F., Wright N., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Yee Liang Hing N., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who hav
- Published
- 2023
5. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
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R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
- Published
- 2023
6. A multi-country analysis of COVID-19 hospitalizations by vaccination status
- Author
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Goncalves, B, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, L, Piubelli, C, Citarella, B, Kartsonaki, C, Lefevre, B, Lopez Revilla, J, Lunn, M, Harrison, E, Kraemer, M, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, P, Merson, L, Abdukahil, S, Jabal, K, Salah, N, Airlangga, E, Hssain, A, Akwani, C, Al Qasim, E, Alberti, A, Aldabbourosama, O, Alessi, M, Alex, B, Al-Fares, A, Aliudin, J, Alkahlout, M, Almasri, L, Al-Saba'a, Y, Alves, R, Cabrita, J, Amaral, M, Ampaw, P, Anchan, A, Angheben, A, Arabi, Y, Arcadipane, A, Archambault, P, Arenz, L, Arora, R, Ashley, E, Atique, A, Atlowly, M, Bach, B, Baillie, J, Baird, J, Balan, V, Barbalho, R, Barbosa, N, Barclay, W, Barnikel, M, Beer, N, Begum, H, Bellemare, D, Beltrame, A, Bertoli, G, Bianco, C, Humaid, F, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, B, Monteiro, F, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, I, Caceres, E, Garces, R, Campisi, J, Canepa, C, Caoili, J, Cardellino, C, Cardoso, F, Cardoso, S, Carney, G, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castaneda, S, Castanheira, N, Cattaneo, P, Cavalin, R, Cavayas, A, Cevik, M, Chaleunphon, B, Chan, A, Chand, M, Chen, A, Cheng, M, Chommanam, D, Chow, Y, Christy, N, Claure-Del Granado, R, Clohisey, S, Codan, C, Connor, M, Cooke, G, Copland, M, Corley, A, Cortegiani, A, Crowl, G, Cruz, C, Csete, M, Custodio, P, da Silva Filipe, A, Dagens, A, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Damas, J, Daneman, N, Dankwa, E, Dantas, J, D'Aragon, F, De Rose, C, de Silva, T, Dechert, W, Denis, E, Dishon, Y, K, D, Docherty, A, Donnelly, C, Donohue, C, Douangdala, P, Douglas, J, Downer, T, Downing, M, Drake, T, Dryden, M, Dubot-Peres, A, Dudman, S, Dunning, J, Duplaix, M, Durham, L, Dyrhol-Riise, A, Edelstein, M, Escher, M, Esperatti, M, Santo, C, Estevao, J, Faheem, A, Fairfield, C, Faria, P, Farshait, N, Fernandes, J, Fernandes, M, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fletcher, T, Flynn, B, Fontela, P, Forsyth, S, Foti, G, Fowler, R, Franch-Llasat, D, Fraser, C, Fraser, J, Ribeiro, A, Friedrich, C, Fuentes, N, G, A, Skeie, L, Gamble, C, Garcia-Diaz, J, Garcia-Gallo, E, Gavin, A, Germano, N, Ghadimi, M, Ghisulal, P, Giani, M, Gibson, J, Girvan, M, Goco, G, Gomez-Junyent, J, Grable, M, Green, C, Greenhalf, W, Griffiths, F, Gruner, H, Gu, Y, Guerguerian, A, Guerreiro, D, Haber, D, Habraken, H, Hafez, W, Hall, M, Halpin, S, Hamdan, S, Hamers, R, Hamza, S, Hardwick, H, Harrison, J, Hartman, A, Heggelund, L, Hendry, R, Hennessy, M, Hesstvedt, L, Higgins, D, Higgins, R, Hinton, S, Ho, A, Holter, J, Horcajada, J, Ming-Yang Hsu, J, Hurd, A, Ijaz, S, Illana, C, Inacio, H, Ippolito, M, Isidoro, T, Jaber, H, Jackson, C, Jaworsky, D, Jenum, S, Jouvet, P, Kalicinska, A, Kandel, C, Katz, K, Kaur, A, Keating, S, Kelly, A, Kelly, S, Kennon, K, Keomany, S, Khalid, I, Kho, M, Khoo, S, Kiiza, P, Granerud, B, Kildal, A, Klenerman, P, Bekken, G, Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. B., Brazzi L., Buchtele N., Buonsenso D., Burrell A., Bustos I. G., Cabrita J., Caceres E., Garces R. C., Campisi J., Canepa C., Caoili J., Cardellino C. S., Cardoso F., Cardoso S., Carney G., Carrier F. M., Carson G., Cascao M., Casimiro J., Castaneda S., Castanheira N., Cattaneo P., Cavalin R., Cavayas A., Cevik M., Chaleunphon B., Chan A., Chand M., Chen A., Cheng M. P., Chommanam D., Chow Y. P., Christy N., Claure-Del Granado R., Clohisey S., Codan C., Connor M., Cooke G. S., Copland M., Corley A., Cortegiani A., Crowl G., Cruz C., Csete M., Custodio P., da Silva Filipe A., Dagens A., Daley P., Dalloul Z., Dalton H., Dalton J., Damas J., Daneman N., Dankwa E. A., Dantas J., D'Aragon F., De Rose C., de Silva T., Dechert W., Denis E., Dishon Y., k Dhangar, Docherty A. B., Donnelly C. A., Donohue C., Douangdala P., Douglas J. J., Downer T., Downing M., Drake T., Dryden M., Dubot-Peres A., Dudman S., Dunning J., Duplaix M., Durham L., Dyrhol-Riise A. M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Mudara C., Muhaisen M., Muller F., Muller K. E., Munshi L., Murthy S., Mustafa D., Nagpal D., Narasimhan M., Nasa P., Nelder M., Neumann E., Ng P. Y., Nichol A. D., Norman L., Notari A., Noursadeghi M., Nusantara D. U., Occhipinti G., O'Hearn K., Oliveira L., Ong D. S. Y., Oosthuyzen W., Openshaw P., Palmarini M., Panarello G., Panda P. K., Parke R., Patricio P., Patterson L., Paul M., Paulos J., Paxton W. A., Pejkovska M., Pereira R., Petrovic M., Pettersen F. O., Pharand S., Phonemixay O., Phoutthavong S., de Piero M., Pimentel C., Pires C., Pitaloka A., Pius R., Poli S., Pollakis G., Post A. -M., Povoas D., Powis J., Praphasiri V., Pritchard M. G., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Rafael A., Rahardjani M., Ramalho J., Rangappa R., Ratsep I., Reeve B., Reikvam D. H., Ren H., Rewa O., Ricchiuto A., Rishu A., Rivera Nunez M. A., Roberts S., Robertson D. L., Roche-Campo F., Rodari P., Roessler B., Rossanese A., Rossetti M., Russell C. D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., Zambon M., Goncalves, B, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, L, Piubelli, C, Citarella, B, Kartsonaki, C, Lefevre, B, Lopez Revilla, J, Lunn, M, Harrison, E, Kraemer, M, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, P, Merson, L, Abdukahil, S, Jabal, K, Salah, N, Airlangga, E, Hssain, A, Akwani, C, Al Qasim, E, Alberti, A, Aldabbourosama, O, Alessi, M, Alex, B, Al-Fares, A, Aliudin, J, Alkahlout, M, Almasri, L, Al-Saba'a, Y, Alves, R, Cabrita, J, Amaral, M, Ampaw, P, Anchan, A, Angheben, A, Arabi, Y, Arcadipane, A, Archambault, P, Arenz, L, Arora, R, Ashley, E, Atique, A, Atlowly, M, Bach, B, Baillie, J, Baird, J, Balan, V, Barbalho, R, Barbosa, N, Barclay, W, Barnikel, M, Beer, N, Begum, H, Bellemare, D, Beltrame, A, Bertoli, G, Bianco, C, Humaid, F, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, B, Monteiro, F, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, I, Caceres, E, Garces, R, Campisi, J, Canepa, C, Caoili, J, Cardellino, C, Cardoso, F, Cardoso, S, Carney, G, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castaneda, S, Castanheira, N, Cattaneo, P, Cavalin, R, Cavayas, A, Cevik, M, Chaleunphon, B, Chan, A, Chand, M, Chen, A, Cheng, M, Chommanam, D, Chow, Y, Christy, N, Claure-Del Granado, R, Clohisey, S, Codan, C, Connor, M, Cooke, G, Copland, M, Corley, A, Cortegiani, A, Crowl, G, Cruz, C, Csete, M, Custodio, P, da Silva Filipe, A, Dagens, A, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Damas, J, Daneman, N, Dankwa, E, Dantas, J, D'Aragon, F, De Rose, C, de Silva, T, Dechert, W, Denis, E, Dishon, Y, K, D, Docherty, A, Donnelly, C, Donohue, C, Douangdala, P, Douglas, J, Downer, T, Downing, M, Drake, T, Dryden, M, Dubot-Peres, A, Dudman, S, Dunning, J, Duplaix, M, Durham, L, Dyrhol-Riise, A, Edelstein, M, Escher, M, Esperatti, M, Santo, C, Estevao, J, Faheem, A, Fairfield, C, Faria, P, Farshait, N, Fernandes, J, Fernandes, M, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fletcher, T, Flynn, B, Fontela, P, Forsyth, S, Foti, G, Fowler, R, Franch-Llasat, D, Fraser, C, Fraser, J, Ribeiro, A, Friedrich, C, Fuentes, N, G, A, Skeie, L, Gamble, C, Garcia-Diaz, J, Garcia-Gallo, E, Gavin, A, Germano, N, Ghadimi, M, Ghisulal, P, Giani, M, Gibson, J, Girvan, M, Goco, G, Gomez-Junyent, J, Grable, M, Green, C, Greenhalf, W, Griffiths, F, Gruner, H, Gu, Y, Guerguerian, A, Guerreiro, D, Haber, D, Habraken, H, Hafez, W, Hall, M, Halpin, S, Hamdan, S, Hamers, R, Hamza, S, Hardwick, H, Harrison, J, Hartman, A, Heggelund, L, Hendry, R, Hennessy, M, Hesstvedt, L, Higgins, D, Higgins, R, Hinton, S, Ho, A, Holter, J, Horcajada, J, Ming-Yang Hsu, J, Hurd, A, Ijaz, S, Illana, C, Inacio, H, Ippolito, M, Isidoro, T, Jaber, H, Jackson, C, Jaworsky, D, Jenum, S, Jouvet, P, Kalicinska, A, Kandel, C, Katz, K, Kaur, A, Keating, S, Kelly, A, Kelly, S, Kennon, K, Keomany, S, Khalid, I, Kho, M, Khoo, S, Kiiza, P, Granerud, B, Kildal, A, Klenerman, P, Bekken, G, Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. 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M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. 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D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., and Zambon M.
- Abstract
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.
- Published
- 2023
7. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
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B., Kimmoun A., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Komatsu M., Korten V., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar D., Kumar G., Tirupakuzhi Vijayaraghavan B. K., Vecham P. K., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lafhej N., Lagrange M., Laine F., Lairez O., Lalueza A., Lambert M., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence T., Lawrence C., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Lee T. C., Lee S. H., Lee J., Lee H. G., Lee B. H., Lee Y. L., Leeming G., Lefebvre L., Lefebvre B., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Letrou S., Levy Y., Levy B., Levy-Marchal C., L'Her E., Bassi G. L., Liang J., Liegeon G., Lim W. S., Lim K. C., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Low L., Lowik M., Loy J. S., Lucet J. C., Bermejo C. L., Luna C. M., Lungu O., Lunn M., Luong L., Luque N., Luton D., Lyons R., Maasikas O., Mabiala O., Machado S., Machado M., Macheda G., Madiha H., Maestro de la Calle G., Mahieu R., Mahy S., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Sant'Ana Malaque C. M., Marino F., Markowicz S., Marques A., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin E., Martin-Blondel G., Martinez F. E., Martin-Loeches I., Martinot M., Martins J., Martins A., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Mason S., Mat Nor M. B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Menon K., Mentre F., Mentzer A. J., Mercier N., Mercier E., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Murphy A., Murphy L., Murray P., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D. M., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Neant N., Necsoi C., Nekliudov N., Neto R., Neumann E., Ng P. Y., Ng W. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Noret M., Izzati Norharizam N. F., Norman L., Notari A., Noursadeghi M., Nseir S., Nusantara D. U., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., Ogura T., O'Halloran S., O'Hearn K., Ohshimo S., Oliveira J., Olliaro P. L., O'Neil C., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. 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F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Proenca L., Pudota S., Puechal O., Semedi B. P., Purcell G., Quesada L., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Qutishat F., Rabaud C., Rafael A., Rafiq M., Rahardjani M., Rahimi A. K., Rahman R. A., Haji Ab Rahman A. K., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Ranjan R., Rapp C., Rasmin M., Ratsep I., Ravi T., Real A., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Remy M., Ren H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Reyes L. F., Ribeiro M. I., Richardson D., Richier L., Atikah Ahmad Ridzuan S. N., Rios A. L., Rishu A., Rispal P., Risso K., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez E., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu H., Shimizu K., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Subekti D., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Svistunov S. A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Mohd Thabit A. A., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thanga Thurai S. R., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Yang Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torre M., Torres A., Torres-Zevallos H., Towers M., Trapani T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turgeon A. F., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Villanueva J. A., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams V., Williams P. J., Wils E. -J., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Kuan P. X., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
- Published
- 2023
8. Liver injury in hospitalized patients with COVID-19: An International observational cohort study
- Author
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C., Lim W. S., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Livrozet M., Lizotte P., Lolong N., Loon L. C., Lopes D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Low L. L., Lowik M., Loy J. S., Lucet J. C., Luna C. M., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Malaque C. M. S., Marino F., Markowicz S., Eid C. M., Marsh L., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Nor B. M., Matan M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Mazzoni T., Sweeney L. M., McArthur C., McCarthy A., McCloskey C., McDermott S., McDonald S. E., McGeer A., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Melo L., Mendes J. J., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed N. N. E., Mohamed T. J., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. 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S., Salvator H., Sanchez O., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schermer T., Scherpereel A., Schneider M., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shimizu H., Shimizu K., Shrapnel S., Mohammed N. S., Siang N. Y., Sibiude J., Sigfrid L., Sillaots P., Silva M. J., Silva R., Heng B. S. L., Singh B. C., Sitompul P. A., Sivam K., Smith S., Smood B., Smyth M., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. 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T., Torres-Zevallos H., Trapani T., Trioux T., Tromeur C., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Uchiyama M., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Valran A., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Xian G. E., Xian L. S., Xuan K. P., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Hing N. Y. L., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., and Zucman D.
- Abstract
Background Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes. Methods We included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component ≥3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI). Results Of 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]). Conclusions Liver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes.
- Published
- 2023
9. Pneumocystosis pneumonia: A comparison study between HIV and non-HIV immunocompromised patients
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Rego de Figueiredo, I., Vieira Alves, R., Drummond Borges, D., Torres, M., Lourenço, F., Antunes, A.M., Gruner, H., and Panarra, A.
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- 2019
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- View/download PDF
10. Gesunde Nerven. Zur Poetik von Nervenheilratgebern um 1900
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Gruner, H., primary
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- 2021
- Full Text
- View/download PDF
11. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
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Murphy, A, Murphy, L, Murris, M, Musaab, H, Muvindi, H, Myrodia, D, Mohd-Hanafiah, F, Nagpal, D, Nagrebetsky, A, Narayanan, N, Khan, R, Nazerali-Maitland, A, Neant, N, Nekliudov, N, Neto, R, Neumann, E, Ng, P, Nghi, A, Nguyen, D, Choileain, O, Leathlobhair, N, Nitayavardhana, P, Nonas, S, Noret, M, Norman, L, Notari, A, Noursadeghi, M, Nowinski, A, Nseir, S, Nunez, J, Nurnaningsih, N, Nyamankolly, E, Brien, F, Callaghan, A, O'Callaghan, A, Occhipinti, G, Oconnor, D, O'Donnell, M, Ogston, T, Ogura, T, O'Halloran, S, O'Hearn, K, Oliveira, J, Oliveira, L, Ong, D, Oosthuyzen, W, Opavsky, A, Openshaw, P, Orakzai, S, Orozco-Chamorro, C, Ortoleva, J, Osatnik, J, O'Shea, L, O'Sullivan, M, Ouamara, N, Ouissa, R, Oziol, E, Pagadoy, M, Pages, J, Palacios, A, Palacios, M, Palmarini, M, Panarello, G, Paneru, H, Panigada, M, Pansu, N, Papadopoulos, A, Parke, R, Parker, M, Parra, B, Pasha, T, Pasquier, J, Pastene, B, Patauner, F, Patrao, L, Patricio, P, Patrier, J, Patterson, L, Pattnaik, R, Paul, C, 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M, Svistunov, A, Syrigos, K, Sztajnbok, J, Szuldrzynski, K, Tabrizi, S, Tagherset, L, Taleb, S, Talsma, J, Tampubolon, M, Tanaka, H, Taqdees, H, Taqi, A, Tardivon, C, Tattevin, P, Taufik, M, Tawfik, H, Tedder, R, Teixeira, J, Tejada, S, Tellier, M, Teoule, F, Terpstra, P, Terrier, O, Terzi, N, Tessier-Grenier, H, Tey, A, Thakur, A, Thibault, V, Thiberville, S, Thill, B, Thompson, S, Thomson, E, Thwaites, R, Tierney, P, Tieroshyn, V, Timashev, P, Timsit, J, Tissot, N, Toki, M, Tonby, K, Torre, M, Torres, A, Torres, M, Torres-Zevallos, H, Towers, M, Trapani, T, Treoux, T, Tromeur, C, Trontzas, I, Trouillon, T, Truong, J, Tual, C, Tubiana, S, Tuite, H, Turmel, J, Turtle, L, Twardowski, P, Uchiyama, M, Udayanga, P, Udy, A, Ullrich, R, Uribe, A, Usman, A, Uyeki, T, Vajdovics, C, Val-Flores, L, Valran, A, Van de Velde, S, van den Berge, M, van der Palen, J, van der Valk, P, Van Der Vekens, N, Van der Voort, P, Van Der Werf, S, van Gulik, L, Van Hattem, J, van Netten, C, van Veen, I, Vanel, 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F., Murthy S., Garcia-Gallo E., Merson L., Ibanez-Prada E. D., Rello J., Fuentes Y. V., Martin-Loeches I., Bozza F., Duque S., Taccone F. S., Fowler R. A., Kartsonaki C., Goncalves B. P., Citarella B. W., Aryal D., Burhan E., Cummings M. J., Delmas C., Diaz R., Figueiredo-Mello C., Hashmi M., Panda P. K., Jimenez M. P., Rincon D. F. B., Thomson D., Nichol A., Marshall J. C., Olliaro P. L., Abbas A., Abdukahil S. A., Abe R., Abel L., Absil L., Acharya S., Acker A., Adriao D., Al Ageel S., Ahmed S., Ainscough K., Aisa T., Hssain A. A., Tamlihat Y. A., Akimoto T., Akmal E., Al Qasim E., Alalqam R., Al-dabbous T., Alegesan S., Alegre C., Alessi M., Alex B., Alexandre K., Al-Fares A., Alfoudri H., Ali I., Shah N. A., Alidjnou K. E., Aliudin J., Alkhafajee Q., Allavena C., Allou N., Altaf A., Alves J., Alves J. M., Alves R., Cabrita J. A., Amaral M., Ampaw P., Andini R., Andrejak C., Angheben A., Angoulvant F., Ansart S., Antonelli M., de Brito C. A. A., Apriyana A., Arabi Y., Aragao I., Araujo C., Arcadipane A., Archambault P., Arenz L., Arlet J. -B., Arnold-Day C., Arora L., Arora R., Artaud-Macari E., Asensio A., Asif N., Asim M., Assie J. B., Atique A., Attanyake A. M. U. L., Auchabie J., Aumaitre H., Auvet A., Azemar L., Azoulay C., Bach B., Bachelet D., Badr C., Baig N., Baillie J. K., Bak E., Bakakos A., Bal A., Balan V., Bani-Sadr F., Barbalho R., Barclay W. S., Barnikel M., Barrasa H., Barrelet A., Barrigoto C., Bartoli M., Baruch J., Basmaci R., Battaglini D., Bauer J., Dow D. B., Beane A., Bedossa A., Begum H., Behilill S., Beishuizen A., Beljantsev A., Bellemare D., Beltrame A., Beluze M., Benech N., Benkerrou D., Bennett S., Bento L., Berdal J. -E., Bergeaud D., Bergin H., Sobrino J. L. B., Bertoli G., Bertolino L., Bessis S., Bevilcaqua S., Bezulier K., Bhatt A., Bhavsar K., Bianco C., Singh M. B., Humaid F. B., Bissuel F., Bitker L., Bitton J., Blanco-Schweizer P., Blier C., Bloos F., Blot M., Boccia F., Bodenes L., Bogaert D., Boivin A. -H., Bolze P. -A., Bompart F., Borges D., Borie R., Bosse H. M., Botelho-Nevers E., Bouadma L., Bouchaud O., Bouchez S., Bouhmani D., Bouhour D., Bouiller K., Bouillet L., Bouisse C., Boureau A. -S., Bourke J., Bouscambert M., Bousquet A., Bouziotis J., Boxma B., Boyer-Besseyre M., Boylan M., Braconnier A., Braga C., Brandenburger T., Monteiro F. B., Brazzi L., Breen D., Breen P., Brickell K., Browne A., Browne S., Brusse-Keizer M., Buchtele N., Buesaquillo C., Bugaeva P., Buisson M., Burrell A., Bustos I. G., Butnaru D., Cabie A., Cabral S., Caceres E., Cadoz C., Garces R. C., Calligy K., Calvache J. A., Camoes J., Campana V., Campbell P., Canepa C., Cantero M., Caraux-Paz P., Carcel S., Cardellino C. S., Cardoso F., Cardoso N., Cardoso S., Carelli S., Carlier N., Carmoi T., Carney G., Carqueja I., Carret M. -C., Carrier F. 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J., Diaz P., Didier K., Diehl J. -L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Djossou F., Docherty A. B., Doherty H., Dondorp A. M., Donnelly C. A., Donnelly M., Donohue C., Donohue S., Donohue Y., Doran P., Dorival C., D'Ortenzio E., Douglas J. J., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Fonseca C. D., Dubee V., Dubos F., Ducancelle A., Dudman S., Dunand P., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Echeverria-Villalobos M., Egan S., Eira C., Sanharawi M. E., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Enderle I., Endo T., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Santo C. E., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C. J., Fakar Z., Fareed K., Faria P., Farooq A., Fatoni A. 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G., Germano N., Ghosn J., Giani M., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J. -C., Golob J., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E. W., Granier P., Grasselli G., Green C. A., Greene C., Greenhalf W., Greffe S., Grieco D. L., Griffee M., Griffiths F., Groenendijk A., Lordemann A. G., Gruner H., Gu Y., Guedj J., Guego M., Guellec D., Guerguerian A. -M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., de Castro M. G., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hadri N., Haidri F., Hakak S., Hall A., Hall M., Halpin S., Hameed J., Hamer A., Hamidfar R., Hammond T., Haniffa R., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hasan M. S., Hashmi J., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Hentzien M., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., Higgins R., Hinchion R., Hinton S., Hitoto H., Ho A., Hoctin A., Hoffmann I., Hoiting O., Holt R., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Hsu J. M. -Y., Hulot J. -S., Huo S., Hurd A., Hussain I., Ijaz S., Ikram A., Illes H. -G., Imbert P., Imran M., Sikander R. I., Imtiaz A., Inacio H., Dominguez C. I., Ippolito M., Isgett S., Isidoro T., Isnard M., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jaud-Fischer C., Jaureguiberry S., Jego F., Jenum S., Garcia R. N. J., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., Jung A., Juzar D., Kafif O., Kaguelidou F., Kali S., Kalomoiri S., Kandamby D. H., Kandel C., Kanwal D., Kataria A., Katz K., Kay C., Keane H., Keating S., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennon K., Kernan M., Kerroumi Y., Keshav S., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khan Q. A., Khanal S., Khatak A., Khawaja A., Kho M. E., Khoo S., Khoso N., Kida Y., Kiiza P., Granerud B. K., Kildal A. B., Kimmoun A., Kindgen-Milles D., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kodippily C., Vasconcelos M. K., Koirala S., Kosgei C., Kpangon A., Krawczyk K., Kruglova O., Kumar D., Kumar M., Vijayaraghavan B. K. T., Vecham P. K., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Santos M. L., Lee J., Lee S. H., Lee T. C., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lennon J., Leon R., Leone M., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Bassi G. L., Liaquat A., Liegeon G., Lim W. S., Lima C., Lina B., Lind A., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Lopes D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Lowik M., Lucet J. C., Bermejo C. L., Luna C. M., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., de la Calle G. M., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandelbrot L., Mankikian J., Manning E., Manuel A., Sant C. M., Malaque A., Marino D., Marino F., Markowicz S., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Martelli C. T., Martin E., Martin-Blondel G., Martinot M., Martins A., Martins J., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Maslove D., Mason S., Masood S., Nor B. M., Matan M., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Evoy N., Mc Sweeney L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Atif M., Meher M., Mele F., Melo L., Memon K., Mendes J. J., Menkiti O., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihnovit V., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mufti A. K., Mullaert J., Muller F., Muller K. E., Munblit D., Muneeb S., Munir N., Murphy A., Murphy L., Murris M., Musaab H., Muvindi H., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Nagrebetsky A., Narayanan N., Khan R. N., Nazerali-Maitland A., Neant N., Nekliudov N., Neto R., Neumann E., Ng P. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. 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M, Sperry, A, Spinuzza, E, Darshana, B, Sriskandan, S, Stabler, S, Staudinger, T, Stecher, S, Stienstra, Y, Stiksrud, B, Stolz, E, Stone, A, Streinu-Cercel, A, Stuart, A, Stuart, D, Suen, G, Suen, J, Sultana, A, Summers, C, Supic, D, Surovcova, M, Svistunov, A, Syrigos, K, Sztajnbok, J, Szuldrzynski, K, Tabrizi, S, Tagherset, L, Taleb, S, Talsma, J, Tampubolon, M, Tanaka, H, Taqdees, H, Taqi, A, Tardivon, C, Tattevin, P, Taufik, M, Tawfik, H, Tedder, R, Teixeira, J, Tejada, S, Tellier, M, Teoule, F, Terpstra, P, Terrier, O, Terzi, N, Tessier-Grenier, H, Tey, A, Thakur, A, Thibault, V, Thiberville, S, Thill, B, Thompson, S, Thomson, E, Thwaites, R, Tierney, P, Tieroshyn, V, Timashev, P, Timsit, J, Tissot, N, Toki, M, Tonby, K, Torre, M, Torres, A, Torres, M, Torres-Zevallos, H, Towers, M, Trapani, T, Treoux, T, Tromeur, C, Trontzas, I, Trouillon, T, Truong, J, Tual, C, Tubiana, S, Tuite, H, Turmel, J, Turtle, L, Twardowski, P, Uchiyama, M, Udayanga, P, Udy, A, Ullrich, R, Uribe, A, 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F., Murthy S., Garcia-Gallo E., Merson L., Ibanez-Prada E. D., Rello J., Fuentes Y. V., Martin-Loeches I., Bozza F., Duque S., Taccone F. S., Fowler R. A., Kartsonaki C., Goncalves B. P., Citarella B. W., Aryal D., Burhan E., Cummings M. J., Delmas C., Diaz R., Figueiredo-Mello C., Hashmi M., Panda P. K., Jimenez M. P., Rincon D. F. B., Thomson D., Nichol A., Marshall J. C., Olliaro P. L., Abbas A., Abdukahil S. A., Abe R., Abel L., Absil L., Acharya S., Acker A., Adriao D., Al Ageel S., Ahmed S., Ainscough K., Aisa T., Hssain A. A., Tamlihat Y. A., Akimoto T., Akmal E., Al Qasim E., Alalqam R., Al-dabbous T., Alegesan S., Alegre C., Alessi M., Alex B., Alexandre K., Al-Fares A., Alfoudri H., Ali I., Shah N. A., Alidjnou K. E., Aliudin J., Alkhafajee Q., Allavena C., Allou N., Altaf A., Alves J., Alves J. M., Alves R., Cabrita J. A., Amaral M., Ampaw P., Andini R., Andrejak C., Angheben A., Angoulvant F., Ansart S., Antonelli M., de Brito C. A. A., Apriyana A., Arabi Y., Aragao I., Araujo C., Arcadipane A., Archambault P., Arenz L., Arlet J. -B., Arnold-Day C., Arora L., Arora R., Artaud-Macari E., Asensio A., Asif N., Asim M., Assie J. B., Atique A., Attanyake A. M. U. L., Auchabie J., Aumaitre H., Auvet A., Azemar L., Azoulay C., Bach B., Bachelet D., Badr C., Baig N., Baillie J. K., Bak E., Bakakos A., Bal A., Balan V., Bani-Sadr F., Barbalho R., Barclay W. S., Barnikel M., Barrasa H., Barrelet A., Barrigoto C., Bartoli M., Baruch J., Basmaci R., Battaglini D., Bauer J., Dow D. B., Beane A., Bedossa A., Begum H., Behilill S., Beishuizen A., Beljantsev A., Bellemare D., Beltrame A., Beluze M., Benech N., Benkerrou D., Bennett S., Bento L., Berdal J. -E., Bergeaud D., Bergin H., Sobrino J. L. B., Bertoli G., Bertolino L., Bessis S., Bevilcaqua S., Bezulier K., Bhatt A., Bhavsar K., Bianco C., Singh M. B., Humaid F. B., Bissuel F., Bitker L., Bitton J., Blanco-Schweizer P., Blier C., Bloos F., Blot M., Boccia F., Bodenes L., Bogaert D., Boivin A. -H., Bolze P. -A., Bompart F., Borges D., Borie R., Bosse H. M., Botelho-Nevers E., Bouadma L., Bouchaud O., Bouchez S., Bouhmani D., Bouhour D., Bouiller K., Bouillet L., Bouisse C., Boureau A. -S., Bourke J., Bouscambert M., Bousquet A., Bouziotis J., Boxma B., Boyer-Besseyre M., Boylan M., Braconnier A., Braga C., Brandenburger T., Monteiro F. B., Brazzi L., Breen D., Breen P., Brickell K., Browne A., Browne S., Brusse-Keizer M., Buchtele N., Buesaquillo C., Bugaeva P., Buisson M., Burrell A., Bustos I. G., Butnaru D., Cabie A., Cabral S., Caceres E., Cadoz C., Garces R. C., Calligy K., Calvache J. A., Camoes J., Campana V., Campbell P., Canepa C., Cantero M., Caraux-Paz P., Carcel S., Cardellino C. S., Cardoso F., Cardoso N., Cardoso S., Carelli S., Carlier N., Carmoi T., Carney G., Carqueja I., Carret M. -C., Carrier F. M., Carroll I., Carson G., Casanova M. -L., Cascao M., Casey S., Casimiro J., Cassandra B., Castaneda S., Castanheira N., Castor-Alexandre G., Castrillon H., Castro I., Catarino A., Catherine F. -X., Cattaneo P., Cavalin R., Cavalli G. G., Cavayas A., Ceccato A., Cervantes-Gonzalez M., Chair A., Chakveatze C., Chan A., Chand M., Auger C. C., Chapplain J. -M., Chas J., Chaudry M., Iniguez J. S. C., Chen A., Chen Y. -S., Cheng M. P., Cheret A., Chiarabini T., Chica J., Chirouze C., Chiumello D., Cho S. -M., Cholley B., Chopin M. -C., Cidade J. P., Herreros J. M. C., Ciullo A., Clarke E., Clarke J., Clohisey S., Cobb P. J., Codan C., Cody C., Coelho A., Coles M., Colin G., Collins M., Colombo S. M., Combs P., Connor M., Conrad A., Contreras S., Conway E., Cooke G. S., Copland M., Cordel H., Corley A., Cornelis S., Cornet A. D., Corpuz A. J., Cortegiani A., Corvaisier G., Costigan E., Couffignal C., Couffin-Cadiergues S., Courtois R., Cousse S., Cregan R., Croonen S., Crowl G., Crump J., Cruz C., Bermudez J. L. C., Rojo J. C., Csete M., Cullen A., Curley G., Curlier E., Curran C., Custodio P., da Silva Filipe A., Da Silveira C., Dabaliz A. -A., Dagens A., Dahly D., Dalton H., Dalton J., Daly S., Damas J., Daneman N., Daniel C., Dankwa E. A., Dantas J., D'Aragon F., de Loughry G., de Mendoza D., De Montmollin E., de Oliveira Franca R. F., de Pinho Oliveira A. I., De Rosa R., de Silva T., de Vries P., Deacon J., Dean D., Debard A., Debray M. -P., DeCastro N., Dechert W., Deconninck L., Decours R., Defous E., Delacroix I., Delaveuve E., Delavigne K., Dell'Amore A., Delobel P., Delsing C., Demonchy E., Denis E., Deplanque D., Depuydt P., Descamps D., Desvallees M., Dewayanti S., Dhanger P., Diallo A., Diamantis S., Dias A., Diaz J. J., Diaz P., Didier K., Diehl J. -L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Djossou F., Docherty A. B., Doherty H., Dondorp A. M., Donnelly C. A., Donnelly M., Donohue C., Donohue S., Donohue Y., Doran P., Dorival C., D'Ortenzio E., Douglas J. J., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Fonseca C. D., Dubee V., Dubos F., Ducancelle A., Dudman S., Dunand P., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Echeverria-Villalobos M., Egan S., Eira C., Sanharawi M. E., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Enderle I., Endo T., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Santo C. E., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C. J., Fakar Z., Fareed K., Faria P., Farooq A., Fatoni A. Z., Faure K., Favory R., Fayed M., Feely N., Feeney L., Fernandes J., Fernandes M. A., Fernandes S., Ferrand F. -X., Devouge E. F., Ferrao J., Ferraz M., Ferreira B., Ferreira I., Ferreira S., Ferrer-Roca R., Ferriere N., Ficko C., Fiorda J., Flament T., Flateau C., Fletcher T., Florio L. L., Flynn D., Foley C., Foley J., Fomin V., Fonseca T., Fontela P., Forsyth S., Foster D., Foti G., Fourn E., Fraher M., Franch-Llasat D., Fraser C., Fraser J. F., Freire M. V., Ribeiro A. F., French C., Friedrich C., Fry S., Fuentes N., Fukuda M., Argin G., Gaborieau V., Gaci R., Gagliardi M., Gagnard J. -C., Gagneux-Brunon A., Gaiao S., Skeie L. G., Gallagher P., Gamble C., Garan A., Garcia R., Barrio N. G., Garimella N., Garot D., Garrait V., Gauli B., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Morlaes L. G., Germano N., Ghosn J., Giani M., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J. -C., Golob J., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E. W., Granier P., Grasselli G., Green C. A., Greene C., Greenhalf W., Greffe S., Grieco D. L., Griffee M., Griffiths F., Groenendijk A., Lordemann A. G., Gruner H., Gu Y., Guedj J., Guego M., Guellec D., Guerguerian A. -M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., de Castro M. G., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hadri N., Haidri F., Hakak S., Hall A., Hall M., Halpin S., Hameed J., Hamer A., Hamidfar R., Hammond T., Haniffa R., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hasan M. S., Hashmi J., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Hentzien M., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., Higgins R., Hinchion R., Hinton S., Hitoto H., Ho A., Hoctin A., Hoffmann I., Hoiting O., Holt R., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Hsu J. M. -Y., Hulot J. -S., Huo S., Hurd A., Hussain I., Ijaz S., Ikram A., Illes H. -G., Imbert P., Imran M., Sikander R. I., Imtiaz A., Inacio H., Dominguez C. I., Ippolito M., Isgett S., Isidoro T., Isnard M., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jaud-Fischer C., Jaureguiberry S., Jego F., Jenum S., Garcia R. N. J., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., Jung A., Juzar D., Kafif O., Kaguelidou F., Kali S., Kalomoiri S., Kandamby D. H., Kandel C., Kanwal D., Kataria A., Katz K., Kay C., Keane H., Keating S., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennon K., Kernan M., Kerroumi Y., Keshav S., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khan Q. A., Khanal S., Khatak A., Khawaja A., Kho M. E., Khoo S., Khoso N., Kida Y., Kiiza P., Granerud B. K., Kildal A. B., Kimmoun A., Kindgen-Milles D., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kodippily C., Vasconcelos M. K., Koirala S., Kosgei C., Kpangon A., Krawczyk K., Kruglova O., Kumar D., Kumar M., Vijayaraghavan B. K. T., Vecham P. K., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Santos M. L., Lee J., Lee S. H., Lee T. C., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lennon J., Leon R., Leone M., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Bassi G. L., Liaquat A., Liegeon G., Lim W. S., Lima C., Lina B., Lind A., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Lopes D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Lowik M., Lucet J. C., Bermejo C. L., Luna C. M., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., de la Calle G. M., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandelbrot L., Mankikian J., Manning E., Manuel A., Sant C. M., Malaque A., Marino D., Marino F., Markowicz S., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Martelli C. T., Martin E., Martin-Blondel G., Martinot M., Martins A., Martins J., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Maslove D., Mason S., Masood S., Nor B. M., Matan M., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Evoy N., Mc Sweeney L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Atif M., Meher M., Mele F., Melo L., Memon K., Mendes J. J., Menkiti O., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihnovit V., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mufti A. K., Mullaert J., Muller F., Muller K. E., Munblit D., Muneeb S., Munir N., Murphy A., Murphy L., Murris M., Musaab H., Muvindi H., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Nagrebetsky A., Narayanan N., Khan R. N., Nazerali-Maitland A., Neant N., Nekliudov N., Neto R., Neumann E., Ng P. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. N., Nitayavardhana P., Nonas S., Noret M., Norman L., Notari A., Noursadeghi M., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., O'Halloran S., O'Hearn K., Oliveira J., Oliveira L., Ong D. S. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Paneru H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Pasha T., Pasquier J., Pastene B., Patauner F., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Picard W., Picone O., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pius R., Plantier L., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Priyadarshani G. D. D., Proenca L., Pudota S., Puechal O., Semedi B. P., Pulicken M., Purcell G., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Rahutullah A., Rainieri F., Ramachandran P., Ramakrishnan N., Ramalho J., Rammaert B., Ramos G. V., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehman A., Reid L., Reikvam D. H., Reis R., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Ribeiro M. I., Richardson D., Richier L., Riera J., Rios A. L., Rishu A., Rispal P., Risso K., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Abreu J. R., Roessler B., Roger P. -M., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Rusmawatiningtyas D., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadaf S., Sadat M., Sahraei V., Saidani N., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Semaille C., Semple M. G., Senneville E., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheharyar A., Shetty R. M., Shi H., Shiekh M., Shimizu K., Shrapnel S., Shrestha S. K., Shrestha P. S., Shum H. P., Mohammed N. S., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva M. J., Silva R., Sin W. C., Singh B. C., Singh P., Sitompul P. A., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song R., Song T., Chia J. S., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. S., Sperry A., Spinuzza E., Darshana B. P. S. R. S., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Suen G., Suen J. Y., Sultana A., Summers C., Supic D., Surovcova M., Svistunov A., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taleb S., Talsma J., Tampubolon M. L., Tanaka H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Teixeira J., Tejada S., Tellier M. -C., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thakur A., Thibault V., Thiberville S. -D., Thill B., Thompson S., Thomson E. C., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toki M., Tonby K., Torre M., Torres A., Torres M., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Vauchy C., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Shukeri W. F. W. M., Wang C. -H., Webb S., Wei J., Weil K., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Yiu N. W., Wong C., Xynogalas I., Yamazaki M., Yazdanpanah Y., Yelnik C., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zahran M., Zambon M., Zanella A., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), a
- Published
- 2022
12. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
- Author
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S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Praphasiri V., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Priyadarshani G. D. D., Proenca L., Pudota S., Puechal O., Semedi B. P., Pulicken M., Puntoni M., Purcell G., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahardjani M., Haji Ab Rahman A. K., Rahman R. A., Rahutullah A., Rainieri F., Rajahram G. S., Ramachandran P., Ramakrishnan N., Ramanathan K., Ramli A. A., Rammaert B., Ramos G. V., Rampello A., Rana A., Rangappa R., Ranjan R., Ranza E., Rapp C., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Rausa F., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehman A., Reid L., Reikvam D. 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S., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satya A., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheharyar A., Shetty R. M., Shetty R., Shi H., Shiban N., Shiekh M., Shiga T., Shime N., Shimizu H., Shimizu K., Shimizu N., Shrestha P. S., Shrestha S. K., Shum H. P., Mohammed N. S., Siang N., Sibiude J., Sibounheuang B., Siddiqui A., Sillaots P., Silva C., Silva M. J., Silva R., Heng B. S. L., Sin W. C., Sinatti D., Singh B. 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L., Valran A., Valzano I., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Dyk M., van Gulik L., Van Hattem J., van Netten C., Van Twillert G., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Van Vinh Chau N., Vishwanathan G., Visseaux B., Visser H., Vitiello C., Vongsouvath M., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Wright N., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yacoub S., Mohdyakop S. R. B., Yamazaki M., Yazdanpanah Y., Hing N. L., Yelnik C., Yeoh C. H., Yerkovich S., Yiaye T., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zoufaly A., and Zucman D.
- Abstract
The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.
- Published
- 2022
13. The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
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J., Douma R., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Dryden M., Duarte Fonseca C., Dubee V., Dubos F., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Dunning J., Duplaix M., Durante-Mangoni E., Durham III L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Ean S. C., Echeverria-Villalobos M., Egan S., Eira C., El Sanharawi M., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Elyazar I., Enderle I., Endo T., Eng C. C., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C. J., Fakar Z., Faria P., Farooq A., Farrar J. J., Farshait N., Fateena H., Fatoni A. Z., Faure K., Favory R., Fayed M., Feely N., Feeney L., Fernandes J., Fernandes M., Fernandes S., Ferrand F. -X., Ferrand Devouge E., Ferrao J., Ferraz M., Ferreira B., Ferreira S., Ferrer-Roca R., Ferriere N., Ficko C., Figueiredo-Mello C., Fiorda J., Flament T., Flateau C., Fletcher T., Florio L. L., Flynn B., Flynn D., Foley C., Foley J., Fomin V., Fonseca T., Fontela P., Forsyth S., Foster D., Foti G., Fourn E., Fowler R. A., Fraher D. M., Franch-Llasat D., Fraser C., Fraser J. F., Freire M. V., Freitas Ribeiro A., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Gaborieau V., Gaci R., Gagliardi M., Gagnard J. -C., Gagne N., Gagneux-Brunon A., Gaiao S., Gail Skeie L., Gallagher P., Gallego Curto E., Gamble C., Gani Y., Garan A., Garcia R., Garcia Barrio N., Garcia-Diaz J., Garcia-Gallo E., Garimella N., Garot D., Garrait V., Gauli B., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Gerbaud Morlaes L., Germano N., ghisulal P. K., Ghosn J., Giani M., Giaquinto C., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Gitahi J., Giwangkancana G., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J. -C., Goh J. Y., Golob J., Gomes R., Gomez K., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gordon A., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E. W., Granier P., Grasselli G., Grazioli L., Green C. A., Greene C., Greenhalf W., Greffe S., Grieco D. L., Griffee M., Griffiths F., Grigoras I., Groenendijk A., Grosse Lordemann A., Gruner H., Gu Y., Guarracino F., Guedj J., Guego M., Guellec D., Guerguerian A. -M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., Guimaraes de Castro M., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hadri N., Haidash O., Haider S., Haidri F., Hakak S., Hall A., Hall M., Halpin S., Hamer A., Hamers R., Hamidfar R., Hammond T., Han L. Y., Haniffa R., Hao K. W., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hartman A., Hashmi J., Hashmi M., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Henriquez A., Hentzien M., Herekar F., Hernandez-Montfort J., Herr D., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., HigginsOKeeffe G., Hinchion R., Hinton S., Hiraiwa H., Hitoto H., Ho A., Ho Y. B., Hoctin A., Hoffmann I., Hoh W. H., Hoiting O., Holt R., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Houltham S., Hsu J. M. -Y., Hulot J. -S., Hussain I., Ijaz S., Illes H. -G., Imbert P., Imran M., Imran Sikander R., Inacio H., Infante Dominguez C., Ing Y. S., Iosifidis E., Ippolito M., Isgett S., Ishani P. G. P. I., Isidoro T., Ismail N., Isnard M., Itai J., Ito A., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Javidfar J., Jawad I., Jaworsky D., Jayakumar D., Jego F., Jelani A. M., Jenum S., Jimbo-Sotomayor R., Job V. D. P., Joe O. Y., Jorge Garcia R. N., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., June J., Jung A., Jung H., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kalicinska A., Kalomoiri S., Kamal S., Kamaluddin M. A. A., Kamaruddin Z. A. C., Kamarudin N., Kandamby D. H., Kandel C., Kang K. Y., Kant R., Kanwal D., Kanyawati D., Karki B., Karpayah P., Karsies T., Kartsonaki C., Kasugai D., Kataria A., Katz K., Kaur A., Kaur Johal S., Kawasaki T., Kay C., Keane H., Keating S., Kellam P., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennedy R., Kennon K., Kernan M., Kerroumi Y., Keshav S., Kestelyn E., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khanal S., Kho M. E., Khoo D., Khoo R., Khoo S., Khoso N., Kiat K. H., Kida Y., Kiiza P., Kildal A. B., Kim J. B., Kimmoun A., Kindgen-Milles D., King A., Kitamura N., Klenerman P., Klont R., Kloumann Bekken G., Knight S., Kobbe R., Kodippily C., Kohns Vasconcelos M., Koirala S., Komatsu M., Korten V., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar A., Kumar D., Kumar G., Kumar M., Kumar Vecham P., Kuriakose D., Kurtzman E., Kusumastuti N. P., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Leal Santos M., Lee B. H., Lee H. G., Lee J., Lee S. H., Lee T. C., Lee Y. 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S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandei J. M., Mandelbrot L., Manetta F., Mangal K., Mankikian J., Manning E., Manuel A., Maria Sant`Ana Malaque C., Marino D., Marino F., Markowicz S., Maroun Eid C., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martinelli A., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins J., Martins N., Martins Rego C., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Masa Jimenez J. F., Maslove D., Mason P., Mason S., Masood S., Mat Nor B., Matan M., Mateus Fernandes H., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Sweeney L., McAndrew L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. 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M., N N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N. A., Nelwan E., Neto R., Neumann E., Neves B., Ng P. Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nichol A., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nyamankolly E., O Brien F., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Olliaro P. L., O'Neil C., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Orquera A., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Owyang C., Oziol E., Pabasara H. M. U., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Panda P. K., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Parrini V., Pasha T., Pasquier J., Pastene B., Patauner F., Patel J., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Pedrera Jimenez M., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pius R., Piva S., Plantier L., Plotkin D., Png H. S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. 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E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Vinh Chau N. V., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S. A., Wei J., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Wing Yiu N., Wong C., Wong T. F., Wong X. C., Wong Y. S., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yacoub S., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Yee Liang Hing N., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Published
- 2021
14. Development of an Arc-Based Diagnostic Procedure for Process Characterization in DC Plasma Spraying
- Author
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Thomas, G., additional, Limburg, M., additional, Mihm, S., additional, Rupprecht, C., additional, and Gruner, H., additional
- Published
- 2022
- Full Text
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15. COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
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McDermott, S, McDonald, S, McElwee, S, McEvoy, N, McGeer, A, McGuinness, N, McLean, KA, McNicholas, B, Meaney, E, Mear-Passard, C, Mechlin, M, Mele, F, Menon, K, Mentre, F, Mentzer, AJ, Mercier, N, Merckx, A, Mergler, B, Merson, L, Mesquita, A, Meybeck, A, Meynert, AM, Meyssonnier, V, Meziane, A, Mezidi, M, Michelanglei, C, Mihnovits, V, Maldonado, HM, Mone, M, Moin, A, Molina, D, Molinos, E, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Moore, SC, Morales-Cely, L, Moro, L, Tutillo, DRM, Motos, A, Mouquet, H, Perrot, CM, Moyet, J, Mullaert, J, Munblit, D, Murphy, D, Murris, M, Myrodia, DM, N'guyen, Y, Neant, N, Neb, H, Nekliudov, NA, Neto, R, Neumann, E, Neves, B, Ng, PY, Ng, WY, Choileain, ON, Nichol, A, Nonas, S, Noret, M, Norman, L, Notari, A, Noursadeghi, M, Nowicka, K, Nseir, S, Nunez, JI, Nyamankolly, E, O'Donnell, M, O'Hearn, K, O'Neil, C, Occhipinti, G, Ogston, T, Ogura, T, Oh, T-H, Ohshimo, S, Oinam, BCS, Oliveira, AP, Oliveira, J, Olliaro, P, Ong, DSY, Oosthuyzen, W, Openshaw, PJM, Orozco-Chamorro, CM, Orquera, A, Osatnik, J, Ouamara, N, Ouissa, R, Owyang, C, Oziol, E, Povoas, D, Pagadoy, M, Pages, J, Palacios, M, Palmarini, M, Panarello, G, Panda, PK, Panigada, M, Pansu, N, Papadopoulos, A, Parra, B, Pasquier, J, Patauner, F, Patrao, L, Paul, C, Paul, M, Paulos, J, Paxton, WA, Payen, J-F, Pearse, I, Peek, GJ, Peelman, F, Peiffer-Smadja, N, Peigne, V, Pejkovska, M, Peltan, ID, Pereira, R, Perez, D, Perpoint, T, Pesenti, A, Petrousova, L, Petrov-Sanchez, V, Peytavin, G, Pharand, S, Piagnerelli, M, Picard, W, Picone, O, Piel-Julian, M, Pierobon, C, Pimentel, C, Piroth, L, Pius, R, Piva, S, Plantier, L, Plotkin, D, Poissy, J, Pokorska-Spiewak, M, Poli, S, Pollakis, G, Popielska, J, Postma, DF, Povoa, P, Powis, J, Prapa, S, Prebensen, C, Preiser, J-C, Prestre, V, Price, N, Prinssen, A, Pritchard, MG, Proenca, L, Puechal, O, Purcell, G, Quesada, L, Quist-Paulsen, E, Quraishi, M, Ratsep, I, Rossler, B, Rabaud, C, Rafiq, M, Ragazzo, G, Rainieri, F, Ramakrishnan, N, Ramanathan, K, Rammaert, B, Rapp, C, Rasmin, M, Rau, C, Rebaudet, S, Redl, S, Reeve, B, Reid, L, Reis, R, Remppis, J, Remy, M, Renk, H, Resende, L, Resseguier, A-S, Revest, M, Rewa, O, Reyes, LF, Richardson, D, Richier, L, Riera, J, Rios, AL, Rishu, A, Rispal, P, Risso, K, Nunez, MAR, Rizer, N, Roberto, A, Roberts, S, Robertson, DL, Robineau, O, Roche-Campo, F, Rodari, P, Rodeia, S, Abreu, JR, Roilides, E, Rojek, A, Romaru, J, Roncon-Albuquerque, R, Roriz, M, Rosa-Calatrava, M, Rose, M, Rosenberger, D, Rossanese, A, Rossignol, B, Rossignol, P, Roy, C, Roze, B, Russell, CD, Ryckaert, S, Holten, AR, Choez, XS, Saba, I, Sadat, M, Saidani, N, Salazar, L, Sales, G, Sallaberry, S, Salvator, H, Sanchez-Miralles, A, Sanchez, O, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarton, B, Saviciute, E, Savvidou, P, Scarsbrook, J, Schermer, T, Scherpereel, A, Schneider, M, Schroll, S, Schwameis, M, Scott-Brown, J, Scott, JT, Sedillot, N, Seitz, T, Semaille, C, Semple, MG, Senneville, E, Sequeira, F, Sequeira, T, Shadowitz, E, Shamsah, M, Sharma, P, Shaw, CA, Shaw, V, Shiban, N, Shime, N, Shimizu, H, Shimizu, K, Shrapnel, S, Shum, HP, Mohammed, NS, Sigfrid, L, Silva, C, Silva, MJ, Sin, WC, Skogen, V, Smith, S, Smood, B, Smyth, M, Snacken, M, So, D, Solis, M, Solomon, J, Solomon, T, Somers, E, Sommet, A, Song, MJ, Song, R, Song, T, Sonntagbauer, M, Soum, E, Uva, MS, Sousa, M, Souza-Dantas, V, Sperry, A, Sriskandan, S, Staudinger, T, Stecher, S-S, Stienstra, Y, Stiksrud, B, Streinu-Cercel, A, Strudwick, S, Stuart, A, Stuart, D, Sultana, A, Summers, C, Surovcova, M, Svistunov, AA, Syrigos, K, Sztajnbok, J, Szuldrzynski, K, Teoule, F, Tabrizi, S, Tagherset, L, Talarek, E, Taleb, S, Talsma, J, Van Tan, L, Tanaka, H, Tanaka, T, Taniguchi, H, Tardivon, C, Tattevin, P, Taufik, MA, Tedder, RS, Teixeira, J, Tellier, M-C, Terpstra, P, Terrier, O, Terzi, N, Tessier-Grenier, H, Thibault, V, Thiberville, S-D, Thill, B, Thompson, AAR, Thompson, S, Thomson, D, Thomson, EC, Thuy, DB, Thwaites, RS, Timashev, PS, Timsit, J-F, Vijayaraghavan, BKT, Toki, M, Tonby, K, Santos-Olmo, RMT, Torres, A, Torres, M, Trioux, T, Trieu, HT, Tromeur, C, Trontzas, I, Troost, J, Trouillon, T, Tual, C, Tubiana, S, Tuite, H, Turtle, LCW, Twardowski, P, Uchiyama, M, Ullrich, R, Uribe, A, Usman, A, Val-Flores, L, Van de Velde, S, Van den Berge, M, Van der Feltz, M, Van der Vekens, N, Van der Voort, P, Van der Werf, S, Van Dyk, M, Van Gulik, L, Van Hattem, J, Van Lelyveld, S, Van Netten, C, Vanel, N, Vanoverschelde, H, Vauchy, C, Veislinger, A, Velazco, J, Ventura, S, Verbon, A, Vieira, C, Villanueva, JA, Villar, J, Villeneuve, P-M, Villoldo, A, Chau, NVV, Visseaux, B, Visser, H, Vuorinen, A, Vuotto, F, Wang, C-H, Wei, J, Weil, K, Wesselius, S, Wham, M, Whelan, B, White, N, Wiedemann, A, Wille, K, Wils, E-J, Xynogalas, I, Suen, JY, Yacoub, S, Yamazaki, M, Yazdanpanah, Y, Yelnik, C, Yerkovich, S, Yokoyama, T, Yonis, H, Young, P, Yuliarto, S, Zabbe, M, Zacharowski, K, Zahran, M, Zambon, M, Zanella, A, Zawadka, K, Zayyad, H, Zoufaly, A, and Zucman, D
- Abstract
BACKGROUND: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. METHODS: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. RESULTS: 'Typical' symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. INTERPRETATION: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
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- 2021
16. Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials
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Pazan, F, Petrovic, M, Cherubini, A, Onder, G, Cruz-Jentoft, AJ, Denkinger, M, van der Cammen, T, Stevenson, J M, Ibrahim, K, Rajkumar, C, Bakken, MS, Baeyens, JP, Crome, P, Frühwald, T, Gallaghar, P, Guðmundsson, A, Knol, W, O’Mahony, D, Pilotto, A, Rönnemaa, E, Serra-Rexach, JA, Soulis, G, van Marum, RJ, Ziere, Bert, Mair, A, Burkhardt, H, Neumann-Podczaska, A, Wieczorowska-Tobis, K, Fernandes, M, Gruner, H, Dallmeier, D, Beuscart, JB, Velde, N, Wehling, M, Pazan, F, Petrovic, M, Cherubini, A, Onder, G, Cruz-Jentoft, AJ, Denkinger, M, van der Cammen, T, Stevenson, J M, Ibrahim, K, Rajkumar, C, Bakken, MS, Baeyens, JP, Crome, P, Frühwald, T, Gallaghar, P, Guðmundsson, A, Knol, W, O’Mahony, D, Pilotto, A, Rönnemaa, E, Serra-Rexach, JA, Soulis, G, van Marum, RJ, Ziere, Bert, Mair, A, Burkhardt, H, Neumann-Podczaska, A, Wieczorowska-Tobis, K, Fernandes, M, Gruner, H, Dallmeier, D, Beuscart, JB, Velde, N, and Wehling, M
- Abstract
Background: Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty. Methods: A literature search was performed in Medline to detect prospective randomized controlled trials (RCTs) testing the effects of pharmacological interventions or medication optimization in older frail adults on comprehensive frailty scores or partial aspects of frailty that were published from January 1998 to October 2019. Results: Twenty-five studies were identified, 4 on comprehensive frailty scores and 21 on aspects of frailty. Two trials on comprehensive frailty scores showed positive results on frailty although the contribution of medication review in a multidimensional approach was unclear. In the studies on aspects related to frailty, ten individual drug interventions showed improvement in physical performance, muscle strength or body composition utilizing alfacalcidol, teriparatide, piroxicam, testosterone, recombinant human chorionic gonadotropin, or capromorelin. There were no studies examining negative effects of drugs on frailty. Conclusion: So far, data on a causal relationship between drugs and frailty are inconclusive or related to single-drug interventions on partial aspects of frailty. There is a clear need for RCTs on this topic that should be based on a comprehensive, internationally consistent and thus reproducible concept of frailty assessment.
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- 2021
17. Tuberculosis infection in HIV vs . non‐HIV patients
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Rego de Figueiredo, I, primary, Branco Ferrão, J, additional, Dias, S, additional, Vieira Alves, R, additional, Drummond Borges, D, additional, Torres, M, additional, Guerreiro Castro, S, additional, Lourenço, F, additional, Antunes, AM, additional, Gruner, H, additional, and Panarra, A, additional
- Published
- 2021
- Full Text
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18. Sjögren's syndrome: State of the art on clinical practice guidelines
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Romao, V, Talarico, R, Scire, C, Vieira, A, Alexander, T, Baldini, C, Gottenberg, J, Gruner, H, Hachulla, E, Mouthon, L, Orlandi, M, Pamfil, C, Pineton De Chambrun, M, Taglietti, M, Toplak, N, Van Daele, P, Van Laar, J, Bombardieri, S, Schneider, M, Smith, V, Cutolo, M, Mosca, M, Mariette, X, Romao V. C., Talarico R., Scire C. A., Vieira A., Alexander T., Baldini C., Gottenberg J. -E., Gruner H., Hachulla E., Mouthon L., Orlandi M., Pamfil C., Pineton De Chambrun M., Taglietti M., Toplak N., Van Daele P., Van Laar J. M., Bombardieri S., Schneider M., Smith V., Cutolo M., Mosca M., Mariette X., Romao, V, Talarico, R, Scire, C, Vieira, A, Alexander, T, Baldini, C, Gottenberg, J, Gruner, H, Hachulla, E, Mouthon, L, Orlandi, M, Pamfil, C, Pineton De Chambrun, M, Taglietti, M, Toplak, N, Van Daele, P, Van Laar, J, Bombardieri, S, Schneider, M, Smith, V, Cutolo, M, Mosca, M, Mariette, X, Romao V. C., Talarico R., Scire C. A., Vieira A., Alexander T., Baldini C., Gottenberg J. -E., Gruner H., Hachulla E., Mouthon L., Orlandi M., Pamfil C., Pineton De Chambrun M., Taglietti M., Toplak N., Van Daele P., Van Laar J. M., Bombardieri S., Schneider M., Smith V., Cutolo M., Mosca M., and Mariette X.
- Abstract
Sjögren's syndrome (SS) is a complex autoimmune rheumatic disease that specifically targets salivary and lachrymal glands. As such, patients typically had ocular and oral dryness and salivary gland swelling. Moreover, skin, nasal and vaginal dryness are frequently present. In addition to dryness, musculoskeletal pain and fatigue are the hallmarks of this disease and constitute the classic symptom triad presented by the vast majority of patients. Up to 30% to 50 % of patients with SS may present systemic disease; moreover, there is an increased risk for the development of non-Hodgkin's lymphoma that occurs in a minority of patients. The present work was developed in the framework of the European Reference Network (ERN) dedicated to Rare and Complex Connective Tissue and Musculoskeletal Diseases (ReCONNET). In line with its goals of aiming to improve early diagnosis, treatment and care of rare connective and musculoskeletal diseases, ERN-ReCONNET set to review the current state of clinical practice guidelines (CPGs) in the rare and complex connective tissue diseases of interest of the network. Therefore, the present work was aimed at providing a state of the art of CPGs for SS.
- Published
- 2018
19. AB1213 DIFFERENT IMMUNOSUPPRESSIVE REGIMENS WITH NO EFFECT ON INFLUENZA-LIKE ILLNESS
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Freixa, M. I., primary, Inácio, H., additional, Amaral, M., additional, Martins, M., additional, Costa, C., additional, Moitinhos, M., additional, Gruner, H., additional, Almeitda, A., additional, Barreto, P., additional, and Pinheiro, S., additional
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- 2020
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20. Topographical characterization and microstructural interface analysis of vacuum-plasma-sprayed titanium and hydroxyapatite coatings on carbon fibre-reinforced poly(etheretherketone)
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HA, S.-W, GISEP, A, MAYER, J, WINTERMANTEL, E, GRUNER, H, and WIELAND, M
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- 1997
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21. NaOH treatment of vacuum-plasma-sprayed titanium on carbon fibre-reinforced poly(etheretherketone)
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HA, S.-W, ECKERT, K.-L, WINTERMANTEL, E, GRUNER, H, GUECHEVA, M, and VONMONT, H
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- 1997
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22. TERRA Erdkunde 7/8: Handbuch Realschulen Nordrhein-Westfalen
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Dresler, W., Kalla, H., Lammersen, R., Ohl, Ulrike, Palmen, P., Pinter, G., Porth, C., Schminke, A., and Gruner, H.
- Published
- 2019
23. TERRA Erdkunde 7/8: Realschule Nordrhein-Westfalen
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Dresler, W., Gruner, H., Kalla, R., Lammersen, H., Ohl, Ulrike, Palmen, P., Pinter, G., Porth, C., and Schminke, A.
- Published
- 2019
24. Vacuum plasma sprayed titanium and hydroxyapatite coatings on carbon fiber reinforced polyetheretherketone (PEEK)
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Ha, S.-W., primary, Gisep, A., additional, Gruner, H., additional, Mayer, J., additional, and Wintermantel, E., additional
- Published
- 1997
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25. Calcium phosphate formation on chemically treated vacuum plasma sprayed titanium coatings
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Ha, S.-W., primary, Eckert, K.-L., additional, Gruner, H., additional, and Wintermantel, E., additional
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- 1997
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- View/download PDF
26. Estudo Monocêntrico da Apresentação Clínica e Prognóstico a Longo Prazo de Doentes Portugueses com Esclerose Sistémica: uma Iniciativa do Registo EUSTAR
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Vidal, C, Ruano, C, Bernardino, V, Lavado Carreira, P, Lladó, A, Santos, MC, Gruner, H, Panarra, A, Riso, N, and Moraes-Fontes, MF
- Subjects
Europe ,Survival Rate ,Time Factors ,Treatment Outcome ,Scleroderma, Systemic/therapy ,HSM IMA ,Scleroderma, Systemic/mortality ,Registries ,HCC MED ,Scleroderma, Systemic/diagnosis - Abstract
INTRODUCTION: Systemic sclerosis is a complex disorder that requires systematic screening. Our objective is to report the European Scleroderma Trials and Research group centre affiliation and its impact in our clinical practice. MATERIAL AND METHODS: The European Scleroderma Trials and Research group affiliation process, database update and current patient evaluation, with respect to demographic and clinical features. Cumulative mortality was analysed. RESULTS: We identified 19 female patients (which met all the American College of Rheumatology/ European League Against Rheumatism 2013 criteria for systemic sclerosis) under current follow-up, divided according to the LeRoy classification into diffuse cutaneous (n = 5), limited cutaneous (n = 11) and limited (n = 3) types, followed for a median period of 5, 12 and 6 years, respectively. Raynaud´s phenomenon and abnormal nailfold capillaries were universally present. Interstitial lung disease was absent in the limited cutaneous form but present in 100% of the diffuse subtype. Pitting scars were more common in the diffuse form. Active disease was also more frequent in the diffuse form, and most patients with active disease were treated with anti-endothelin receptor antagonists. Over 21 years (from 1994 to 2015) the mortality rate was 55% (n = 23/42). Age at time of death was significantly lower in the diffuse subtype. DISCUSSION: Our single centre cohort shares many features with larger and international reports and more specifically is in accordance with patient characteristics described in the European Scleroderma Trials and Research group registries. CONCLUSION: The European Scleroderma Trials and Research group registration motivated our systematic patient characterization and may be used as a tool for homogenous disease registries. info:eu-repo/semantics/publishedVersion
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- 2018
27. Topographical characterization and microstructural interface analysis of vacuum-plasma-sprayed titanium and hydroxyapatite coatings on carbon fibre-reinforced poly(etheretherketone)
- Author
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Ha, S.-W, Gisep, A, Mayer, J, Wintermantel, E, Gruner, H, and Wieland, M
- Abstract
Journal of Materials Science. Materials in Medicine, 8 (12), ISSN:0957-4530, ISSN:1573-4838
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- 2018
28. NaOH treatment of vacuum-plasma-sprayed titanium on carbon fibre-reinforced poly(etheretherketone)
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Ha, S.-W, Eckert, K.-L, Wintermantel, E, Gruner, H, Guecheva, M, and Vonmont, H
- Abstract
Journal of Materials Science. Materials in Medicine, 8 (12), ISSN:0957-4530, ISSN:1573-4838
- Published
- 2018
29. SUN-PO044: Nutritional Evaluation in a Geriatric Clinic
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Rego De Figueiredo, I., primary, Saldanha, M., additional, Gonçalves, C., additional, Luis, M., additional, Guerreiro, J., additional, Silva, R., additional, Santos, C., additional, Luz Ramires, M., additional, and Gruner, H., additional
- Published
- 2019
- Full Text
- View/download PDF
30. Sjögren's syndrome: State of the art on clinical practice guidelines
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Romão, V.C. (Vasco C.), Talarico, R. (Rosaria), Scirè, C.A. (Carlo Alberto), Vieira, A. (Ana), Alexander, T. (Tobias), Baldini, C. (Chiara), Gottenberg, J.-E. (Jacques-Eric), Gruner, H. (Heidi), Hachulla, E. (Eric), Mouthon, L. (Luc), Orlandi, M. (Martina), Pamfil, C. (Cristina), Pineton De Chambrun, M. (Marc), Taglietti, M. (Marco), Toplak, N. (Natasa), Daele, P.L.A. (Paul) van, Van Laar, J.M. (Jacob M), Bombardieri, S. (Stefano), Schneider, M. (Matthias), Smith, V. (Vanessa), Cutolo, M. (Maurizio), Mosca, M. (Marta), Mariette, X. (Xavier), Romão, V.C. (Vasco C.), Talarico, R. (Rosaria), Scirè, C.A. (Carlo Alberto), Vieira, A. (Ana), Alexander, T. (Tobias), Baldini, C. (Chiara), Gottenberg, J.-E. (Jacques-Eric), Gruner, H. (Heidi), Hachulla, E. (Eric), Mouthon, L. (Luc), Orlandi, M. (Martina), Pamfil, C. (Cristina), Pineton De Chambrun, M. (Marc), Taglietti, M. (Marco), Toplak, N. (Natasa), Daele, P.L.A. (Paul) van, Van Laar, J.M. (Jacob M), Bombardieri, S. (Stefano), Schneider, M. (Matthias), Smith, V. (Vanessa), Cutolo, M. (Maurizio), Mosca, M. (Marta), and Mariette, X. (Xavier)
- Abstract
Sjögren's syndrome (SS) is a complex autoimmune rheumatic disease that specifically targets salivary and lachrymal glands. As such, patients typically had ocular and oral dryness and salivary gland swelling. Moreover, skin, nasal and vaginal dryness are frequently present. In addition to dryness, musculoskeletal pain and fatigue are the hallmarks of this disease and constitute the classic symptom triad presented by the vast majority of patients. Up to 30% to 50 % of patients with SS may present systemic disease; moreover, there is an increased risk for the development of non-Hodgkin's lymphoma that occurs in a minority of patients. The present work was developed in the framework of the European Reference Network (ERN) dedicated to Rare and Complex Connective Tissue and Musculoskeletal Diseases (ReCONNET). In line with its goals of aiming to improve early diagnosis, treatment and care of rare connective and musculoskeletal diseases, ERN-ReCONNET set to review the current state of clinical practice guidelines (CPGs) in the rare and complex connective tissue diseases of interest of the network. Therefore, the present work was aimed at providing a state of the art of CPGs for SS.
- Published
- 2018
- Full Text
- View/download PDF
31. Sjogren's syndrome: state of the art on clinical practice guidelines
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Romao, VC, Talarico, R, Scire, CA, Vieira, A, Alexander, T, Baldini, C, Gottenberg, JE, Gruner, H, Hachulla, E, Mouthon, L, Orlandi, M, Pamfil, C, de Chambrun, MP, Taglietti, M, Toplak, N, van Daele, Paul, van Laar, JM, Bombardieri, S, Schneider, M, Smith, V, Cutolo, M, Mosca, M, Mariette, X, Romao, VC, Talarico, R, Scire, CA, Vieira, A, Alexander, T, Baldini, C, Gottenberg, JE, Gruner, H, Hachulla, E, Mouthon, L, Orlandi, M, Pamfil, C, de Chambrun, MP, Taglietti, M, Toplak, N, van Daele, Paul, van Laar, JM, Bombardieri, S, Schneider, M, Smith, V, Cutolo, M, Mosca, M, and Mariette, X
- Published
- 2018
32. A Plan for a Crustaceorum Catalogus
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Gruner, H.-E. and Holthuis, L. B.
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- 1965
33. Revision der Familie Mesoniscidae Verhoeff, 1908 (Isopoda, Oniscoidea)
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Gruner, H.-E. and Tabacaru, I.
- Published
- 1963
34. Rectoskopie als Vorsorgeuntersuchung ?
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Kanzler, G., Beck, K., Gruner, H. J., Ottenjann, R., Remmele, W., Strauch, M., and Schlegel, B., editor
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- 1972
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35. The Arc Movement as a Source of Process Instability for Single-Cathode-Anode Systems – A New Method for Direct Investigation
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Thomas, G., additional, Mihm, S., additional, Limburg, M., additional, and Gruner, H., additional
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- 2017
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36. Liver structure and function during long-term treatment with cyproterone acetate
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Kaiser, E. and Gruner, H. S.
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- 1987
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37. SAT0364 Diagnosis of Latent Tuberculosis in Patients Undergoing Biological Therapy
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Guerreiro Castro, S., primary, Patarata, E., additional, Gruner, H., additional, Gomes, C., additional, Moraes Fontes, M.F., additional, and Riso, N., additional
- Published
- 2015
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38. Behandlung schwerer Androgenisierungserscheinungen mit Diane® und intramuskulär appliziertem Cyproteronacetat (Androcur®- Depot)
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Kaiser, E., primary and Gruner, H. S., additional
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- 1987
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39. VACUUM PLASMA SPRAYED COMPOSITE COATINGS
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Gruner, H., primary
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- 1986
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40. Beziehungen zwischen Sammlerwirkung und Korngröße der Mineralteilchen - Untersuchungen mit Zinnstein und Bleiglanz
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Wottgen, E, primary and Gruner, H, additional
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- 1967
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41. 42. Schleimhauthistologie des operierten Ulcusmagens im Vergleich von selektiver Vagotomie und Magenresektion
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Reifferscheid, M., Gruner, H. J., and Peters, H.
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- 1967
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42. P011: Risk factors for pressure ulcers in an internal medicine ward
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Fernandes, M.A., primary, Seara, A., additional, Lavado, P., additional, Popovik, M., additional, Bras, V., additional, Patarata, E., additional, Antunes, A., additional, Sabino, V., additional, Romão, F., additional, Baptista, M., additional, Gruner, H., additional, Ferreira, A., additional, and Riso, N., additional
- Published
- 2014
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43. P010: Diagnostic procedures in stroke patients in an internal medicine ward
- Author
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Magalhaes, F., primary, Marques, B.A., additional, Popocvik, M., additional, Fernandes, M.A., additional, Bras, V., additional, Lavado, P., additional, Patarata, E., additional, Castro, S., additional, Antunes, A., additional, Baptista, M., additional, Ferreira, A., additional, Gruner, H., additional, and Riso, N., additional
- Published
- 2014
- Full Text
- View/download PDF
44. Neoplasia in rheumatoid arthritis patients using a biological agent in an autoimmune diseases unit
- Author
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Castro, S. Guerreiro, primary, Antunes, M., additional, Magalhães, F.G., additional, Silva, M., additional, Patarata, E., additional, Gruner, H., additional, Moraes-Fontes, F., additional, Ferreira, A., additional, and Riso, N., additional
- Published
- 2013
- Full Text
- View/download PDF
45. Follow up in the physical medicine and rehabilitation consult of patients with rheumatoid arthritis using a biological agent
- Author
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Silva, M., primary, Castro, S. Guerreiro, additional, Magalhães, F.G., additional, Antunes, M., additional, Patarata, E., additional, Gruner, H., additional, Moraes-Fontes, M.F., additional, Ferreira, A., additional, and Riso, N., additional
- Published
- 2013
- Full Text
- View/download PDF
46. Cardiorenal syndrome in the elderly in an internal medicine ward
- Author
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Gonçalves, C., primary, Antunes, A.M., additional, Magalhaes, F.G., additional, Silva, M., additional, Gruner, H., additional, and Ventura, M., additional
- Published
- 2012
- Full Text
- View/download PDF
47. Reducing the Cost of Thermal Barrier Coatings by Optimizing the Atmospheric Plasma Spray Process
- Author
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Mihm, S., additional, Duda, T., additional, Thomas, G., additional, Gruner, H., additional, and Dzur, B., additional
- Published
- 2011
- Full Text
- View/download PDF
48. Fiscal Policy and Growth: Do Financial Crises Make a Difference?
- Author
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Afonso, António, primary, Gruner, H. P., additional, and Kolerus, Christina Elisabeth, additional
- Published
- 2010
- Full Text
- View/download PDF
49. Herreid, Clyde F., & Fourtner, Charles R. (Edits.): Locomotion and Energetics in Arthropods. 546 S., zahlreiche Abb. u. Tab.; Plenum Press (New York), 1981. US $ 59,50. - ISBN 0-306-40830-9
- Author
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Gruner, H.-E., primary
- Published
- 2008
- Full Text
- View/download PDF
50. Tautz, Jürgen: Medienbewegung in der Sinneswelt der Arthropoden. Fallstudien zu einer Sinnesökologie. Information Processing in Animals. Vol. 6 (1989): 1-59, 35 Abb., 17 × 24 cm, kt. DM 37,-. Veröffentl. der Akademie der Wissenschaften u. d. Literatur, Ma
- Author
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Gruner, H.-E., primary
- Published
- 2008
- Full Text
- View/download PDF
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