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CAS has emerged as an alternative to carotid endarterectomy for the treatment of significant carotid artery stenosis. We investigated if the side of the stenosis treated has an influence on the neurological outcome of our patients. CAS was performed in 1124 patients at our center. The left carotid artery (group L) was intervened in 557 and the right carotid artery (group R) in 567 patients. Data of both patient groups were analyzed with respect to the total rate of peri-interventional ischemic cerebral events, defined as transient ischemic attacks, minor and major strokes, respectively. The total peri-interventional ischemic cerebral event rate was 10.1% in group L and 6.7% in group R (p = 0.042), respectively. The routine use of a filter wire resulted in a significant reduction of complication rates in group L (from 14.7 to 7.1%; p = 0.005) but not in group R (from 7.8 to 6.0%; p = 0.505). Ischemic cerebral events did not differ between group L and R, when only patients in whom a filter wire was used were analyzed (7.1% in group L and 6.0% in group R, p = 0.174). Peri-interventional ischemic cerebral complication rates in patients undergoing CAS differ with respect to the side treated. This may be due to a more frequent plaque mobilization caused by the guiding catheter.

Dynamic processes in the Earth's interior are the dominant driving forces behind the continuous deformation-related reworking of its surface. The characterization of deformation caused by past tectonic events near the Earth's surface as well as mapping of ongoing dynamic-driven processes deep inside the Earth are therefore major objectives to understand the dynamics of our planet. Seismic anisotropy, the direction-dependence of seismic wave speed, is directly related to deformation processes and can be "felt" by passing seismic waves. Although seismic anisotropy is a well-known phenomenon, the individual contributions from different depth ranges are still debated. However, recordings available from dense and large-aperture seismic station networks, provide the opportunity for resolving both, small-scale variations relatively close to the surface as well as so far unknown structures at greater depth. In 2012, an international seismological field experiment, called ScanArray, was initiated. The combination of 72 temporary broadband stations with long-running national permanent stations and arrays resulted in a recording network consisting of 266 seismic stations in total that were distributed across the Fennoscandian peninsula in northern Europe. Fennoscandia opens the opportunity to study the (past) geodynamical evolution of crustal and upper mantle structures far away from currently active plate tectonics. The main goal of this study is to characterize the anisotropic structure beneath the Fennoscandian peninsula as well as in the Earth's lowermost mantle based on a uniformly processed data set provided by the ScanArray network. For this purpose single-event shear wave splitting analysis was performed using core-refracted shear waves (SKS, SKKS, PKS) of around 3000 globally distributed teleseismic earthquakes (1998-2017). In order to improve the data coverage at a recording station, a new plugin (StackSplit) for a widely applied analysis software (SplitLab) is introduced allowing efficient and flexible handling of multi-event splitting measurements. Based on the massive seismic data set, this study provides a comprehensive characterization of the distinct lateral and backazimuthal variations of the shear wave splitting pattern at individual stations and across the ScanArray network. These variations partly correlate well with different tectonic regimes related to past large-scale lithospheric deformation due to ancient collision events. Detailed forward modeling allowed to explore different anisotropic structural geometries including anisotropy with a dipping axis of symmetry. Although, the majority of the shear wave splitting observations can be explained with high reliability, for a small number of recording stations non-unique anisotropy models were found which fit the observed data equally well. Furthermore, this study sheds light on lowermost mantle anisotropy located in the so-called D" layer just atop the core-mantle boundary in ~ 2900 km depth. This unexpected discovery is based on observations of distinct splitting discrepancies between teleseismic SKS and SKKS phases for the same source-receiver configuration. The lowermost mantle anisotropy can be associated with two large-scale seismic velocity anomalies beneath the North Atlantic and northwestern Siberia. Even though the exact geometry and mechanism of the anisotropic fabrics in D" cannot be fully constrained by ScanArray recordings alone, these new observations provide important and much-needed boundary conditions for improved future geodynamic mantle modeling.

LITHOS-CAPP is the German contribution to the international ScanArray experiment. ScanArray is an array of broadband seismometers with which we aim to study the lithosphere and upper mantle beneath the Scandinavian Mountains and the Baltic Shield. LITHOS-CAPP contributed 20 broadband recording stations from September 2014 to October 2016, 10 in Sweden and 10 in Finland, continuously recordings at 100 samples per second. The stations were deployed by the KIT Geophysical Institute and GFZ section 2.4 (seismology). They form part of the temporary network ScanArrayCore (FDSN network code 1G 2012-2017), Scientific Technical Report STR - Data; 17/02, GIPP Experiment and Data Archive

Transcatheter pulmonary valve (TPV) replacement is an effective therapy of right ventricular outflow tract conduit dysfunction. Acute complications after TPV implantation include infective endocarditis, stent fracture, and device dislocation. We present a novel, life-threatening complication: an acute, noninfectious TPV thrombosis. Within 24 hours after implantation of a Melody system (Medtronic, Inc, Minneapolis, MN), the patient developed an acute TPV thrombosis characterized by severe TPV stenosis on echocardiography and contrast filling defects on computed tomography pulmonary angiography images. Genetic testing revealed heterozygous prothrombin G20210A polymorphism and homozygous 4G/4G polymorphism of the plasminogen-activator-inhibitor. The patient recovered after surgical valve replacement with a pulmonary homograft.