1. Classic gout in Hageman factor (Factor XII) deficiency.
- Author
-
Green D, Arsever CL, Grumet KA, and Ratnoff OD
- Subjects
- Extremities, Factor XII, Gout metabolism, Humans, Kinins analysis, Male, Middle Aged, Synovial Fluid analysis, Factor XII Deficiency, Gout complications
- Abstract
A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.
- Published
- 1982