1. Research progress of m 6 A regulation during animal growth and development.
- Author
-
Hengwei Y, Raza SHA, Wenzhen Z, Xinran Y, Almohaimeed HM, Alshanwani AR, Assiri R, Aggad WS, and Zan L
- Subjects
- Animals, Growth and Development genetics, Humans, Methylation, RNA metabolism, RNA, Messenger genetics, Adenosine genetics, Adenosine metabolism, Neoplasms genetics
- Abstract
Environmental factors, genetic factors, and epigenetics are involved in animal growth and development. Among them, methylation is one of the abundant modifications of epigenetics. N6-methyladenosine(m
6 A) is extensive in cellular RNA, of which mRNA is the most common internal modification. m6 A modification regulates life activities dynamically and reversibly, including expressed genes, RNA metabolism, and protein translation. The m6 A modifications are closely related to human diseases involving heart failure, tumors, and cancer. It is relatively in-depth in the medical field. However, there are few studies on its biochemical function in animals. We summarized the latest paper related to the chemical structure and role of the writers, the erasers, and the readers to study exerting dynamic regulation of m6 A modification of animal growth and development. Furthermore, the key roles of m6 A modification were reported in the process of RNA metabolism. Finally, the dynamic regulation of m6 A modification in animal growth and development was reviewed, including brain development, fertility, fat deposition, and muscle production. It reveals the key roles of m6 A modification and the regulation of gene expression, aiming to provide new ideas for m6 A methylation in animal growth and development., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2022 Elsevier Ltd. All rights reserved.)- Published
- 2022
- Full Text
- View/download PDF