Search

Your search keyword '"Grove, James C. R."' showing total 12 results
Start Over Author "Grove, James C. R."
12 results on '"Grove, James C. R."'

5. Rapid deployment of SARS-CoV-2 testing: The CLIAHUB

Author

Crawford, Emily D., primary, Acosta, Irene, additional, Ahyong, Vida, additional, Anderson, Erika C., additional, Arevalo, Shaun, additional, Asarnow, Daniel, additional, Axelrod, Shannon, additional, Ayscue, Patrick, additional, Azimi, Camillia S., additional, Azumaya, Caleigh M., additional, Bachl, Stefanie, additional, Bachmutsky, Iris, additional, Bhaduri, Aparna, additional, Brown, Jeremy Bancroft, additional, Batson, Joshua, additional, Behnert, Astrid, additional, Boileau, Ryan M., additional, Bollam, Saumya R., additional, Bonny, Alain R., additional, Booth, David, additional, Borja, Michael Jerico B., additional, Brown, David, additional, Buie, Bryan, additional, Burnett, Cassandra E., additional, Byrnes, Lauren E., additional, Cabral, Katelyn A., additional, Cabrera, Joana P., additional, Caldera, Saharai, additional, Canales, Gabriela, additional, Castañeda, Gloria R., additional, Chan, Agnes Protacio, additional, Chang, Christopher R., additional, Charles-Orszag, Arthur, additional, Cheung, Carly, additional, Chio, Unseng, additional, Chow, Eric D., additional, Citron, Y. Rose, additional, Cohen, Allison, additional, Cohn, Lillian B., additional, Chiu, Charles, additional, Cole, Mitchel A., additional, Conrad, Daniel N., additional, Constantino, Angela, additional, Cote, Andrew, additional, Crayton-Hall, Tre’Jon, additional, Darmanis, Spyros, additional, Detweiler, Angela M., additional, Dial, Rebekah L., additional, Dong, Shen, additional, Duarte, Elias M., additional, Dynerman, David, additional, Egger, Rebecca, additional, Fanton, Alison, additional, Frumm, Stacey M., additional, Fu, Becky Xu Hua, additional, Garcia, Valentina E., additional, Garcia, Julie, additional, Gladkova, Christina, additional, Goldman, Miriam, additional, Gomez-Sjoberg, Rafael, additional, Gordon, M. Grace, additional, Grove, James C. R., additional, Gupta, Shweta, additional, Haddjeri-Hopkins, Alexis, additional, Hadley, Pierce, additional, Haliburton, John, additional, Hao, Samantha L., additional, Hartoularos, George, additional, Herrera, Nadia, additional, Hilberg, Melissa, additional, Ho, Kit Ying E., additional, Hoppe, Nicholas, additional, Hosseinzadeh, Shayan, additional, Howard, Conor J., additional, Hussmann, Jeffrey A., additional, Hwang, Elizabeth, additional, Ingebrigtsen, Danielle, additional, Jackson, Julia R., additional, Jowhar, Ziad M., additional, Kain, Danielle, additional, Kim, James Y. S., additional, Kistler, Amy, additional, Kreutzfeld, Oriana, additional, Kulsuptrakul, Jessie, additional, Kung, Andrew F., additional, Langelier, Charles, additional, Laurie, Matthew T., additional, Lee, Lena, additional, Leng, Kun, additional, Leon, Kristoffer E., additional, Leonetti, Manuel D., additional, Levan, Sophia R., additional, Li, Sam, additional, Li, Aileen W., additional, Liu, Jamin, additional, Lubin, Heidi S., additional, Lyden, Amy, additional, Mann, Jennifer, additional, Mann, Sabrina, additional, Margulis, Gorica, additional, Marquez, Diana M., additional, Marsh, Bryan P., additional, Martyn, Calla, additional, McCarthy, Elizabeth E., additional, McGeever, Aaron, additional, Merriman, Alexander F., additional, Meyer, Lauren K., additional, Miller, Steve, additional, Moore, Megan K., additional, Mowery, Cody T., additional, Mukhtar, Tanzila, additional, Mwakibete, Lusajo L., additional, Narez, Noelle, additional, Neff, Norma F., additional, Osso, Lindsay A., additional, Oviedo, Diter, additional, Peng, Suping, additional, Phelps, Maira, additional, Phong, Kiet, additional, Picard, Peter, additional, Pieper, Lindsey M., additional, Pincha, Neha, additional, Pisco, Angela Oliveira, additional, Pogson, Angela, additional, Pourmal, Sergei, additional, Puccinelli, Robert R., additional, Puschnik, Andreas S., additional, Rackaityte, Elze, additional, Raghavan, Preethi, additional, Raghavan, Madhura, additional, Reese, James, additional, Replogle, Joseph M., additional, Retallack, Hanna, additional, Reyes, Helen, additional, Rose, Donald, additional, Rosenberg, Marci F., additional, Sanchez-Guerrero, Estella, additional, Sattler, Sydney M., additional, Savy, Laura, additional, See, Stephanie K., additional, Sellers, Kristin K., additional, Serpa, Paula Hayakawa, additional, Sheehy, Maureen, additional, Sheu, Jonathan, additional, Silas, Sukrit, additional, Streithorst, Jessica A., additional, Strickland, Jack, additional, Stryke, Doug, additional, Sunshine, Sara, additional, Suslow, Peter, additional, Sutanto, Renaldo, additional, Tamura, Serena, additional, Tan, Michelle, additional, Tan, Jiongyi, additional, Tang, Alice, additional, Tato, Cristina M., additional, Taylor, Jack C., additional, Tenvooren, Iliana, additional, Thompson, Erin M., additional, Thornborrow, Edward C., additional, Tse, Eric, additional, Tung, Tony, additional, Turner, Marc L., additional, Turner, Victoria S., additional, Turnham, Rigney E., additional, Turocy, Mary J., additional, Vaidyanathan, Trisha V., additional, Vainchtein, Ilia D., additional, Vanaerschot, Manu, additional, Vazquez, Sara E., additional, Wandler, Anica M., additional, Wapniarski, Anne, additional, Webber, James T., additional, Weinberg, Zara Y., additional, Westbrook, Alexandra, additional, Wong, Allison W., additional, Wong, Emily, additional, Worthington, Gajus, additional, Xie, Fang, additional, Xu, Albert, additional, Yamamoto, Terrina, additional, Yang, Ying, additional, Yarza, Fauna, additional, Zaltsman, Yefim, additional, Zheng, Tina, additional, and DeRisi, Joseph L., additional

Published
2020
Full Text
View/download PDF

8. Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.

Author

de los Santos, Janira, Purohit, Shashvat, Grove, James C. R., Hirano, Arlene A., Brecha, Nicholas C., Barnes, Steven, McHugh, Cyrus F., and Field, Greg D.

Subjects
GABA, RETINAL cone photoreceptor cells, GABA receptors, HYDROGEN-ion concentration, SYNAPSES
Abstract

The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal transmission. The mechanisms underlying the regulation of graded photoreceptor synaptic output in this nonspiking network have remained elusive. Here, we analyze with patch clamp recording the novel mechanisms by which horizontal cells control pH in the synaptic cleft to modulate photoreceptor neurotransmitter release. First, we show that mammalian horizontal cells respond to their own GABA release and that the results of this autaptic action affect cone voltage-gated Ca2+ channel (CaV channel) gating through changes in pH. As a proof-of-principle, we demonstrate that chemogenetic manipulation of horizontal cells with exogenous anion channel expression mimics GABA-mediated cone CaV channel inhibition. Activation of these GABA receptor anion channels can depolarize horizontal cells and increase cleft acidity via Na+/H+ exchanger (NHE) proton extrusion, which results in inhibition of cone CaV channels. This action is effectively counteracted when horizontal cells are sufficiently hyperpolarized by increased GABA receptor (GABAR)-mediated HCO3− efflux, alkalinizing the cleft and disinhibiting cone CaV channels. This demonstrates how hybrid actions of GABA operate in parallel to effect voltage-dependent pH changes, a novel mechanism for regulating synaptic output. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

10. Dopamine D1 receptor modulation of calcium channel currents in horizontal cells of mouse retina.

Author

Xue Liu, Grove, James C. R., Hirano, Arlene A., Brecha, Nicholas C., and Barnes, Steven

Subjects
*DOPAMINE, *CALCIUM channels, *CIRCADIAN rhythms, *DOPAMINERGIC mechanisms, *GUANOSINE
Abstract

Horizontal cells form the first laterally interacting network of inhibitory interneurons in the retina. Dopamine released onto horizontal cells under photic and circadian control modulates horizontal cell function. Using isolated, identified horizontal cells from a connexin-57-iCre × ROSA26-tdTomato transgenic mouse line, we investigated dopaminergic modulation of calcium channel currents (ICa) with whole cell patch-clamp techniques. Dopamine (10 μM) blocked 27% of steadystate ICa, an action blunted to 9% in the presence of the L-type Ca channel blocker verapamil (50 μM). The dopamine type 1 receptor (D1R) agonist SKF38393 (20 μM) inhibited ICa by 24%. The D1R antagonist SCH23390 (20 μM) reduced dopamine and SKF38393 inhibition. Dopamine slowed ICa activation, blocking ICa by 38% early in a voltage step. Enhanced early inhibition of ICa was eliminated by applying voltage prepulses to +120 mV for 100 ms, increasing ICa by 31% and 11% for early and steady-state currents, respectively. Voltage-dependent facilitation of ICa and block of dopamine inhibition after preincubation with a Gβγ-blocking peptide suggested involvement of Gβγ proteins in the D1R-mediated modulation. When the G protein activator guanosine 5'-O-(3-thiotriphosphate) (GTPγS) was added intracellularly, ICa was smaller and showed the same slowed kinetics seen during D1R activation. With GTPγS in the pipette, additional block of ICa by dopamine was only 6%. Strong depolarizing voltage prepulses restored the GTPγS-reduced early ICa amplitude by 36% and steady-state ICa amplitude by 3%. These results suggest that dopaminergic inhibition of ICa via D1Rs is primarily mediated through the action of Gβγ proteins in horizontal cells. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

11. Enteroendocrine cell types that drive food reward and aversion.

Author

Bai L, Sivakumar N, Yu S, Mesgarzadeh S, Ding T, Ly T, Corpuz TV, Grove JCR, Jarvie BC, and Knight ZA

Subjects
Animals, Cholecystokinin metabolism, Food Preferences, Mice, Reward, Taste, Enteroendocrine Cells metabolism, Food
Abstract

Animals must learn through experience which foods are nutritious and should be consumed, and which are toxic and should be avoided. Enteroendocrine cells (EECs) are the principal chemosensors in the GI tract, but investigation of their role in behavior has been limited by the difficulty of selectively targeting these cells in vivo. Here, we describe an intersectional genetic approach for manipulating EEC subtypes in behaving mice. We show that multiple EEC subtypes inhibit food intake but have different effects on learning. Conditioned flavor preference is driven by release of cholecystokinin whereas conditioned taste aversion is mediated by serotonin and substance P. These positive and negative valence signals are transmitted by vagal and spinal afferents, respectively. These findings establish a cellular basis for how chemosensing in the gut drives learning about food., Competing Interests: LB, NS, SY, SM, TD, TL, TC, JG, BJ, ZK No competing interests declared, (© 2022, Bai et al.)

Published
2022
Full Text
View/download PDF

12. Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity.

Author

Koren D, Grove JCR, and Wei W

Subjects
Action Potentials drug effects, Action Potentials physiology, Amino Acids pharmacology, Animals, Animals, Newborn, Cadmium Chloride pharmacology, Calcium Channel Blockers pharmacology, Dendrites drug effects, Excitatory Amino Acid Antagonists pharmacology, Female, Inhibitory Postsynaptic Potentials physiology, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Photic Stimulation, Receptors, AMPA genetics, Receptors, AMPA metabolism, Retina physiology, Signal Transduction drug effects, Signal Transduction genetics, Synapses drug effects, Synapses physiology, Xanthenes pharmacology, omega-Conotoxin GVIA pharmacology, Amacrine Cells cytology, Amacrine Cells physiology, Dendrites physiology, Motion Perception physiology, Retina cytology, Signal Transduction physiology
Abstract

Compartmentalized signaling in dendritic subdomains is critical for the function of many central neurons. In the retina, individual dendritic sectors of a starburst amacrine cell (SAC) are preferentially activated by different directions of linear motion, indicating limited signal propagation between the sectors. However, the mechanism that regulates this propagation is poorly understood. Here, we find that metabotropic glutamate receptor 2 (mGluR2) signaling, which acts on voltage-gated calcium channels in SACs, selectively restricts cross-sector signal propagation in SACs, but does not affect local dendritic computation within individual sectors. mGluR2 signaling ensures sufficient electrotonic isolation of dendritic sectors to prevent their depolarization during non-preferred motion, yet enables controlled multicompartmental signal integration that enhances responses to preferred motion. Furthermore, mGluR2-mediated dendritic compartmentalization in SACs is important for the functional output of direction-selective ganglion cells (DSGCs). Therefore, our results directly link modulation of dendritic compartmentalization to circuit-level encoding of motion direction in the retina., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results