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1. Cohort description:measures of early-life behaviour and later psychopathology in the LifeCycle Project — EU Child Cohort Network

Author

Nader, J. L. (Johanna L.), López-Vicente, M. (Mònica), Julvez, J. (Jordi), Guxens, M. (Monica), Cadman, T. (Tim), Elhakeem, A. (Ahmed), Järvelin, M.-R. (Marjo-Riitta), Rautio, N. (Nina), Miettunen, J. (Jouko), El Marroun, H. (Hanan), Melchior, M. (Maria), Heude, B. (Barbara), Charles, M.-A. (Marie-Aline), Yang, T. C. (Tiffany C.), McEachan, R. R. (Rosemary R. C.), Wright, J. (John), Polanska, K. (Kinga), Carson, J. (Jennie), Lin, A. (Ashleigh), Rauschert, S. (Sebastian), Huang, R.-C. (Rae-Chi), Popovic, M. (Maja), Richiardi, L. (Lorenzo), Corpeleijn, E. (Eva), Cardol, M. (Marloes), Mikkola, T. M. (Tuija M.), Eriksson, J. G. (Johan G.), Salika, T. (Theodosia), Inskip, H. (Hazel), Vinther, J. L. (Johan Lerbech), Strandberg-Larsen, K. (Katrine), Gürlich, K. (Kathrin), Grote, V. (Veit), Koletzko, B. (Berthold), Vafeiadi, M. (Marina), Sunyer, J. (Jordi), Jaddoe, V. W. (Vincent W. V.), Harris, J. R. (Jennifer R.), Nader, J. L. (Johanna L.), López-Vicente, M. (Mònica), Julvez, J. (Jordi), Guxens, M. (Monica), Cadman, T. (Tim), Elhakeem, A. (Ahmed), Järvelin, M.-R. (Marjo-Riitta), Rautio, N. (Nina), Miettunen, J. (Jouko), El Marroun, H. (Hanan), Melchior, M. (Maria), Heude, B. (Barbara), Charles, M.-A. (Marie-Aline), Yang, T. C. (Tiffany C.), McEachan, R. R. (Rosemary R. C.), Wright, J. (John), Polanska, K. (Kinga), Carson, J. (Jennie), Lin, A. (Ashleigh), Rauschert, S. (Sebastian), Huang, R.-C. (Rae-Chi), Popovic, M. (Maja), Richiardi, L. (Lorenzo), Corpeleijn, E. (Eva), Cardol, M. (Marloes), Mikkola, T. M. (Tuija M.), Eriksson, J. G. (Johan G.), Salika, T. (Theodosia), Inskip, H. (Hazel), Vinther, J. L. (Johan Lerbech), Strandberg-Larsen, K. (Katrine), Gürlich, K. (Kathrin), Grote, V. (Veit), Koletzko, B. (Berthold), Vafeiadi, M. (Marina), Sunyer, J. (Jordi), Jaddoe, V. W. (Vincent W. V.), and Harris, J. R. (Jennifer R.)

Abstract

Background: The EU LifeCycle Project was launched in 2017 to combine, harmonise, and analyse data from more than 250,000 participants across Europe and Australia, involving cohorts participating in the EU-funded LifeCycle Project. The purpose of this cohort description is to provide a detailed overview over the major measures within mental health domains that are available in 17 European and Australian cohorts participating in the LifeCycle Project. Methods: Data on cognitive, behavioural and psychological development has been collected on participants from birth until adulthood through questionnaire and medical data. We developed an inventory of the available data by mapping individual instruments, domain types, and age groups, providing the basis for statistical harmonization across mental health measures. Results: The mental health data in LifeCycle contain longitudinal and cross-sectional data for ages 0–18+ years, covering domains across a wide range of behavioural and psychopathology indicators and outcomes (including executive function, depression, ADHD and cognition). These data span a unique combination of qualitative data collected through behavioural/cognitive/mental health questionnaires and examination, as well as data from biological samples and indices in the form of brain imaging (MRI, foetal ultrasound) and DNA methylation data. Harmonized variables on a subset of mental health domains have been developed, providing statistical equivalence of measures required for longitudinal meta-analyses across instruments and cohorts. Conclusions: Mental health data harmonized through the LifeCycle project can be used to study life course trajectories and exposure-outcome models that examine early life risk factors for mental illness and develop predictive markers for later-life disease.

Published
2023

2. The EU Child Cohort Network’s core data:establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

Author

Pinot de Moira, A. (Angela), Haakma, S. (Sido), Strandberg-Larsen, K. (Katrine), van Enckevort, E. (Esther), Kooijman, M. (Marjolein), Cadman, T. (Tim), Cardol, M. (Marloes), Corpeleijn, E. (Eva), Crozier, S. (Sarah), Duijts, L. (Liesbeth), Elhakeem, A. (Ahmed), Eriksson, J. G. (Johan G.), Felix, J. F. (Janine F.), Fernandez-Barres, S. (Silvia), Foong, R. E. (Rachel E.), Forhan, A. (Anne), Grote, V. (Veit), Guerlich, K. (Kathrin), Heude, B. (Barbara), Huang, R.-C. (Rae-Chi), Järvelin, M.-R. (Marjo-Riitta), Jorgensen, A. C. (Anne Cathrine), Mikkola, T. M. (Tuija M.), Nader, J. L. (Johanna L. T.), Pedersen, M. (Marie), Popovic, M. (Maja), Rautio, N. (Nina), Richiardi, L. (Lorenzo), Ronkainen, J. (Justiina), Roumeliotaki, T. (Theano), Salika, T. (Theodosia), Sebert, S. (Sylvain), Vinther, J. L. (Johan L.), Voerman, E. (Ellis), Vrijheid, M. (Martine), Wright, J. (John), Yang, T. C. (Tiffany C.), Zariouh, F. (Faryal), Charles, M.-A. (Marie-Aline), Inskip, H. (Hazel), Jaddoe, V. W. (Vincent W. V.), Swertz, M. A. (Morris A.), Nybo Andersen, A.-M. (Anne-Marie), Pinot de Moira, A. (Angela), Haakma, S. (Sido), Strandberg-Larsen, K. (Katrine), van Enckevort, E. (Esther), Kooijman, M. (Marjolein), Cadman, T. (Tim), Cardol, M. (Marloes), Corpeleijn, E. (Eva), Crozier, S. (Sarah), Duijts, L. (Liesbeth), Elhakeem, A. (Ahmed), Eriksson, J. G. (Johan G.), Felix, J. F. (Janine F.), Fernandez-Barres, S. (Silvia), Foong, R. E. (Rachel E.), Forhan, A. (Anne), Grote, V. (Veit), Guerlich, K. (Kathrin), Heude, B. (Barbara), Huang, R.-C. (Rae-Chi), Järvelin, M.-R. (Marjo-Riitta), Jorgensen, A. C. (Anne Cathrine), Mikkola, T. M. (Tuija M.), Nader, J. L. (Johanna L. T.), Pedersen, M. (Marie), Popovic, M. (Maja), Rautio, N. (Nina), Richiardi, L. (Lorenzo), Ronkainen, J. (Justiina), Roumeliotaki, T. (Theano), Salika, T. (Theodosia), Sebert, S. (Sylvain), Vinther, J. L. (Johan L.), Voerman, E. (Ellis), Vrijheid, M. (Martine), Wright, J. (John), Yang, T. C. (Tiffany C.), Zariouh, F. (Faryal), Charles, M.-A. (Marie-Aline), Inskip, H. (Hazel), Jaddoe, V. W. (Vincent W. V.), Swertz, M. A. (Morris A.), and Nybo Andersen, A.-M. (Anne-Marie)

Abstract

The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.

Published
2021

3. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Author

Vehmeijer, F.O.L. (Florianne O.L.), Küpers, A.M. (Marlijn), Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Lent, S. (Samantha), Jima, D.D. (Dereje D.), Tindula, G. (Gwen), Reese, S.E. (Sarah E.), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F.I. (Faisal I.), Melton, P.E. (Philip E.), Nohr, C. (Christian), Escaramís, G. (Geòrgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S.T. (Samuli T.), Gao, L. (Lu), Ross, J.P. (Jason P.), Starling, A.P. (Anne P.), Holloway, J.W. (John W.), Yousefi, P. (Paul), Aasvang, G.M. (Gunn Marit), Beilin, L.J. (Lawrence), Bergström, A. (Anna), Binder, E.B. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (B.), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Håberg, S.E. (Siri E), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, C.A. (Christian), Langhendries, J.P. (Jean Paul), Lepeule, J. (Johanna), Magnus, M.C. (Maria C.), Maguire, R.L. (Rachel L.), Molloy, P.L. (Peter L.), Poppelaars-Monnereau, C. (Claire), Mori, T.A. (Trevor A.), Oken, E. (Emily), Räikkönen, K. (Katri), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J.M. (Judith), Xu, C.-J. (Cheng-Jian), Yang, I.V. (Ivana V.), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B.S. (Beverly S.), Breton, C. (Carrie), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sørensen, T.I.A. (Thorkild), Huang, R.-C. (Rae-Chi), Arshad, S.H. (Syed), Nystad, W. (Wenche), Melén, E. (Erik), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S.K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A.A. (Andrea), Relton, C.L. (Caroline), Snieder, H. (Harold), Jaddoe, V.W.V. (Vincent), Felix, J.F. (Janine), Vehmeijer, F.O.L. (Florianne O.L.), Küpers, A.M. (Marlijn), Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Lent, S. (Samantha), Jima, D.D. (Dereje D.), Tindula, G. (Gwen), Reese, S.E. (Sarah E.), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F.I. (Faisal I.), Melton, P.E. (Philip E.), Nohr, C. (Christian), Escaramís, G. (Geòrgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S.T. (Samuli T.), Gao, L. (Lu), Ross, J.P. (Jason P.), Starling, A.P. (Anne P.), Holloway, J.W. (John W.), Yousefi, P. (Paul), Aasvang, G.M. (Gunn Marit), Beilin, L.J. (Lawrence), Bergström, A. (Anna), Binder, E.B. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (B.), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Håberg, S.E. (Siri E), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, C.A. (Christian), Langhendries, J.P. (Jean Paul), Lepeule, J. (Johanna), Magnus, M.C. (Maria C.), Maguire, R.L. (Rachel L.), Molloy, P.L. (Peter L.), Poppelaars-Monnereau, C. (Claire), Mori, T.A. (Trevor A.), Oken, E. (Emily), Räikkönen, K. (Katri), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J.M. (Judith), Xu, C.-J. (Cheng-Jian), Yang, I.V. (Ivana V.), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B.S. (Beverly S.), Breton, C. (Carrie), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sørensen, T.I.A. (Thorkild), Huang, R.-C. (Rae-Chi), Arshad, S.H. (Syed), Nystad, W. (Wenche), Melén, E. (Erik), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S.K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A.A. (Andrea), Relton, C.L. (Caroline), Snieder, H. (Harold), Jaddoe, V.W.V. (Vincent), and Felix, J.F. (Janine)

Abstract

Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions: There were only minimal associations of DNA methylation with childhood and adolescent BMI.

Published
2020
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4. The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

Author

Jaddoe, V.W.V. (Vincent), Felix, J.F. (Janine), Andersen, A-M.N. (Anne-Marie Nybo), Charles, M.A., Chatzi, L. (Leda), Corpeleijn, E. (Eva), Donner, N. (Nina), Elhakeem, A. (Ahmed), Hagen, K. (Knut), Foong, R. (Rachel), Grote, V. (Veit), Haakma, S. (Sido), Hanson, M. (Mark), Harris, J.R. (Jennifer), Heude, B. (Barbara), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Järvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Lawlor, D.A. (Debbie), Lindeboom, M. (Maarten), McEachan, R.R.C. (Rosemary R. C.), Mikkola, T.M. (Tuija M.), Nader, J.L.T. (Johanna L. T.), de Moira, A.P. (Angela Pinot), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Sebert, S. (Sylvain), Schwalber, A. (Ameli), Sunyer, J. (Jordi), Swertz, M.A. (Morris A.), Vafeiadi, M. (Marina), Vrijheid, M. (Martine), Wright, J. (John), Duijts, L. (Liesbeth), El Marroun, H. (Hanan), Gaillard, R. (Romy), Santos, S. (Susana), Geurtsen, M.L. (Madelon L.), Kooijman, M.N. (Marjolein), Mensink-Bout, S.M. (Sara M.), Vehmeijer, F.O.L. (Florianne O.L.), Voerman, E. (Ellis), Nieuwenhuijsen, M. (Mark), Basagaña, X. (Xavier), Bustamante, M. (Mariona), Casas, M. (Miguel), de Castro, M. (Montserrat), Cirugeda, L.E. (Lourdes E.), Fernández-Barrés, S., Fossati, S. (Serena), Garcia, R. (Raquel), Julvez, J. (Jordi), Lertxundi, A. (Aitana), Lertxundi, N. (Nerea), Llop, S. (Sabrina), López-Vicente, M. (Mònica), Lopez-Espinosa, M.-J. (Maria-Jose), Maitre, L. (Lea), Murcia, M. (Mario), Lea, J. (Jose), Urquiza, H. (H.), Warembourg, C. (Charline), Zugna, D. (Daniela), Popovic, M. (Maja), Isaevska, E. (Elena), Maule, M. (Milena), Moccia, C. (Chiara), Moirano, G. (Giovenale), Rasella, D. (Davide), Hanson, M.A. (Mark A.), Inskip, H.M. (Hazel M.), Jacob, C.M. (Chandni Maria), Salika, T. (Theodosia), Cadman, T. (Tim), Strandberg-Larsen, K.M. (Katrine M.), Pedersen, M. (Marie), Vinther, J.L. (Johan L.), Wilson, P. (Paul), Mason, D. (Dan), Yang, T.C. (Tiffany C.), Cardol, M. (Marloes), van Enckevoort, E. (Esther), Hyde, E. (Eleanor), Scholtens, S. (Salome), Snieder, H. (Harold), Thio, C.H.L. (Chris H. L.), Chatzi, L. (Lida), Margetaki, K.C.A. (Katerina C. A.), Roumeliotaki, T. (Theano), Nader, J.L. (Johanna L.), Knudsen, G.P. (Gun Peggy), Magnus, P. (Per), Panico, L. (Lidia), Ichou, M. (Mathieu), de Lauzon-Guillain, B. (Blandine), Dargent-Molina, P. (Patricia), Cornet, M. (Maxime), Florian, S.M. (Sandra M.), Harrar, F. (Faryal), Lepeule, J. (Johanna), Lioret, S., Melchior, M. (Maria), Plancoulaine, S. (Sabine), Männikkö, M. (Minna), Parmar, P. (Priyanka), Rautio, N. (Nina), Ronkainen, J. (Justiina), Tolvanen, M. (Mimmi), Aumüller, N. (Nicole), Closa-Monasterolo, R. (Ricardo), Escribano, J. (Joaquin), Ferré, N. (Natalia), Gruszfeld, D. (Dariusz), Gürlich, K. (Kathrin), Langhendries, J.P. (Jean Paul), Luque, V. (Verónica), Riva, E. (Enrica), Schwarzfischer, P. (Phillipp), Totzauer, M. (Martina), Verduci, E. (Elvira), Xhonneux, A. (Annick), Zaragoza-Jordana, M. (Marta), Schwalber, A. (Amelie), Foong, R.E. (Rachel E.), Hall, G.L. (Graham L.), Lin, A. (Ashleigh), Carson, J. (Jennie), Melton, P. (Phillip), Rauschert, S. (Sebastian), Jaddoe, V.W.V. (Vincent), Felix, J.F. (Janine), Andersen, A-M.N. (Anne-Marie Nybo), Charles, M.A., Chatzi, L. (Leda), Corpeleijn, E. (Eva), Donner, N. (Nina), Elhakeem, A. (Ahmed), Hagen, K. (Knut), Foong, R. (Rachel), Grote, V. (Veit), Haakma, S. (Sido), Hanson, M. (Mark), Harris, J.R. (Jennifer), Heude, B. (Barbara), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Järvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Lawlor, D.A. (Debbie), Lindeboom, M. (Maarten), McEachan, R.R.C. (Rosemary R. C.), Mikkola, T.M. (Tuija M.), Nader, J.L.T. (Johanna L. T.), de Moira, A.P. (Angela Pinot), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Sebert, S. (Sylvain), Schwalber, A. (Ameli), Sunyer, J. (Jordi), Swertz, M.A. (Morris A.), Vafeiadi, M. (Marina), Vrijheid, M. (Martine), Wright, J. (John), Duijts, L. (Liesbeth), El Marroun, H. (Hanan), Gaillard, R. (Romy), Santos, S. (Susana), Geurtsen, M.L. (Madelon L.), Kooijman, M.N. (Marjolein), Mensink-Bout, S.M. (Sara M.), Vehmeijer, F.O.L. (Florianne O.L.), Voerman, E. (Ellis), Nieuwenhuijsen, M. (Mark), Basagaña, X. (Xavier), Bustamante, M. (Mariona), Casas, M. (Miguel), de Castro, M. (Montserrat), Cirugeda, L.E. (Lourdes E.), Fernández-Barrés, S., Fossati, S. (Serena), Garcia, R. (Raquel), Julvez, J. (Jordi), Lertxundi, A. (Aitana), Lertxundi, N. (Nerea), Llop, S. (Sabrina), López-Vicente, M. (Mònica), Lopez-Espinosa, M.-J. (Maria-Jose), Maitre, L. (Lea), Murcia, M. (Mario), Lea, J. (Jose), Urquiza, H. (H.), Warembourg, C. (Charline), Zugna, D. (Daniela), Popovic, M. (Maja), Isaevska, E. (Elena), Maule, M. (Milena), Moccia, C. (Chiara), Moirano, G. (Giovenale), Rasella, D. (Davide), Hanson, M.A. (Mark A.), Inskip, H.M. (Hazel M.), Jacob, C.M. (Chandni Maria), Salika, T. (Theodosia), Cadman, T. (Tim), Strandberg-Larsen, K.M. (Katrine M.), Pedersen, M. (Marie), Vinther, J.L. (Johan L.), Wilson, P. (Paul), Mason, D. (Dan), Yang, T.C. (Tiffany C.), Cardol, M. (Marloes), van Enckevoort, E. (Esther), Hyde, E. (Eleanor), Scholtens, S. (Salome), Snieder, H. (Harold), Thio, C.H.L. (Chris H. L.), Chatzi, L. (Lida), Margetaki, K.C.A. (Katerina C. A.), Roumeliotaki, T. (Theano), Nader, J.L. (Johanna L.), Knudsen, G.P. (Gun Peggy), Magnus, P. (Per), Panico, L. (Lidia), Ichou, M. (Mathieu), de Lauzon-Guillain, B. (Blandine), Dargent-Molina, P. (Patricia), Cornet, M. (Maxime), Florian, S.M. (Sandra M.), Harrar, F. (Faryal), Lepeule, J. (Johanna), Lioret, S., Melchior, M. (Maria), Plancoulaine, S. (Sabine), Männikkö, M. (Minna), Parmar, P. (Priyanka), Rautio, N. (Nina), Ronkainen, J. (Justiina), Tolvanen, M. (Mimmi), Aumüller, N. (Nicole), Closa-Monasterolo, R. (Ricardo), Escribano, J. (Joaquin), Ferré, N. (Natalia), Gruszfeld, D. (Dariusz), Gürlich, K. (Kathrin), Langhendries, J.P. (Jean Paul), Luque, V. (Verónica), Riva, E. (Enrica), Schwarzfischer, P. (Phillipp), Totzauer, M. (Martina), Verduci, E. (Elvira), Xhonneux, A. (Annick), Zaragoza-Jordana, M. (Marta), Schwalber, A. (Amelie), Foong, R.E. (Rachel E.), Hall, G.L. (Graham L.), Lin, A. (Ashleigh), Carson, J. (Jennie), Melton, P. (Phillip), and Rauschert, S. (Sebastian)

Abstract

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform

Published
2020
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5. DNA methylation and body mass index from birth to adolescence:meta-analyses of epigenome-wide association studies

Author

Vehmeijer, F. O. (Florianne O. L.), Kuepers, L. K. (Leanne K.), Sharp, G. C. (Gemma C.), Salas, L. A. (Lucas A.), Lent, S. (Samantha), Jima, D. D. (Dereje D.), Tindula, G. (Gwen), Reese, S. (Sarah), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F. I. (Faisal, I), Melton, P. E. (Philip E.), Nohr, E. (Ellen), Escaramis, G. (Georgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S. T. (Samuli T.), Gao, L. (Lu), Ross, J. P. (Jason P.), Starling, A. P. (Anne P.), Holloway, J. W. (John W.), Yousefi, P. (Paul), Aasvang, G. M. (Gunn Marit), Beilin, L. J. (Lawrence J.), Bergstrom, A. (Anna), Binder, E. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (Brenda), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Haberg, S. E. (Siri E.), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, I. (Inger), Langhendries, J.-P. (Jean-Paul), Lepeule, J. (Johanna), Magnus, M. C. (Maria C.), Maguire, R. L. (Rachel L.), Molloy, P. L. (Peter L.), Monnereau, C. (Claire), Mori, T. A. (Trevor A.), Oken, E. (Emily), Raikkonen, K. (Katri), Rifas-Shiman, S. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J. M. (Judith M.), Xu, C.-j. (Cheng-jian), Yang, I. V. (Ivana, V), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B. S. (Beverly S.), Breton, C. V. (Carrie, V), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sorensen, T. I. (Thorkild I. A.), Huang, R.-C. (Rae-Chi), Arshad, S. H. (Syed Hasan), Nystad, W. (Wenche), Melen, E. (Erik), Koppelman, G. H. (Gerard H.), London, S. J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S. K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A. (Andrea), Relton, C. L. (Caroline L.), Snieder, H. (Harold), Jaddoe, V. W. (Vincent W. V.), Felix, J. F. (Janine F.), Vehmeijer, F. O. (Florianne O. L.), Kuepers, L. K. (Leanne K.), Sharp, G. C. (Gemma C.), Salas, L. A. (Lucas A.), Lent, S. (Samantha), Jima, D. D. (Dereje D.), Tindula, G. (Gwen), Reese, S. (Sarah), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F. I. (Faisal, I), Melton, P. E. (Philip E.), Nohr, E. (Ellen), Escaramis, G. (Georgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S. T. (Samuli T.), Gao, L. (Lu), Ross, J. P. (Jason P.), Starling, A. P. (Anne P.), Holloway, J. W. (John W.), Yousefi, P. (Paul), Aasvang, G. M. (Gunn Marit), Beilin, L. J. (Lawrence J.), Bergstrom, A. (Anna), Binder, E. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (Brenda), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Haberg, S. E. (Siri E.), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, I. (Inger), Langhendries, J.-P. (Jean-Paul), Lepeule, J. (Johanna), Magnus, M. C. (Maria C.), Maguire, R. L. (Rachel L.), Molloy, P. L. (Peter L.), Monnereau, C. (Claire), Mori, T. A. (Trevor A.), Oken, E. (Emily), Raikkonen, K. (Katri), Rifas-Shiman, S. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J. M. (Judith M.), Xu, C.-j. (Cheng-jian), Yang, I. V. (Ivana, V), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B. S. (Beverly S.), Breton, C. V. (Carrie, V), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sorensen, T. I. (Thorkild I. A.), Huang, R.-C. (Rae-Chi), Arshad, S. H. (Syed Hasan), Nystad, W. (Wenche), Melen, E. (Erik), Koppelman, G. H. (Gerard H.), London, S. J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S. K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A. (Andrea), Relton, C. L. (Caroline L.), Snieder, H. (Harold), Jaddoe, V. W. (Vincent W. V.), and Felix, J. F. (Janine F.)

Abstract

Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10⁻⁷, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10⁻⁴; adolescence Penrichment = 2.10 × 10⁻⁷). Conclusions: There were only minimal associations of DNA methylation with childhood and adol

Published
2020

6. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Author

Vogelezang, S. (Suzanne), Bradfield, J. P. (Jonathan P.), Ahluwalia, T. S. (Tarunveer S.), Curtin, J. A. (John A.), Lakka, T. A. (Timo A.), Grarup, N. (Niels), Scholz, M. (Markus), van der Most, P. J. (Peter J.), Monnereau, C. (Claire), Stergiakouli, E. (Evie), Heiskala, A. (Anni), Horikoshi, M. (Momoko), Fedko, I. O. (Iryna O.), Vilor-Tejedor, N. (Natalia), Cousminer, D. L. (Diana L.), Standl, M. (Marie), Wang, C. A. (Carol A.), Viikari, J. (Jorma), Geller, F. (Frank), iniguez, C. (Carmen), Pitkanen, N. (Niina), Chesi, A. (Alessandra), Bacelis, J. (Jonas), Yengo, L. (Loic), Torrent, M. (Maties), Ntalla, I. (Ioanna), Helgeland, O. (Oyvind), Selzam, S. (Saskia), Vonk, J. M. (Judith M.), Zafarmand, M. H. (Mohammed H.), Heude, B. (Barbara), Farooqi, I. S. (Ismaa Sadaf), Alyass, A. (Akram), Beaumont, R. N. (Robin N.), Have, C. T. (Christian T.), Rzehak, P. (Peter), Bilbao, J. R. (Jose Ramon), Schnurr, T. M. (Theresia M.), Barroso, I. (Ines), Bonnelykke, K. (Klaus), Beilin, L. J. (Lawrence J.), Carstensen, L. (Lisbeth), Charles, M.-A. (Marie-Aline), Chawes, B. (Bo), Clement, K. (Karine), Closa-Monasterolo, R. (Ricardo), Custovic, A. (Adnan), Eriksson, J. G. (Johan G.), Escribano, J. (Joaquin), Groen-Blokhuis, M. (Maria), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Hakonarson, H. (Hakon), Hansen, T. (Torben), Hattersley, A. T. (Andrew T.), Hollensted, M. (Mette), Hottenga, J.-J. (Jouke-Jan), Hypponen, E. (Elina), Johansson, S. (Stefan), Joro, R. (Raimo), Kahonen, M. (Mika), Karhunen, V. (Ville), Kiess, W. (Wieland), Knight, B. A. (Bridget A.), Koletzko, B. (Berthold), Kuehnapfel, A. (Andreas), Landgraf, K. (Kathrin), Langhendries, J.-P. (Jean-Paul), Lehtimaki, T. (Terho), Leinonen, J. T. (Jaakko T.), Li, A. (Aihuali), Lindi, V. (Virpi), Lowry, E. (Estelle), Bustamante, M. (Mariona), Medina-Gomez, C. (Carolina), Melbye, M. (Mads), Michaelsen, K. F. (Kim F.), Morgen, C. S. (Camilla S.), Mori, T. A. (Trevor A.), Nielsen, T. R. (Tenna R. H.), Niinikoski, H. (Harri), Oldehinkel, A. J. (Albertine J.), Pahkala, K. (Katja), Panoutsopoulou, K. (Kalliope), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Power, C. (Christine), Reijneveld, S. A. (Sijmen A.), Rivadeneira, F. (Fernando), Simpson, A. (Angela), Sly, P. D. (Peter D.), Stokholm, J. (Jakob), Teo, K. K. (Kook K.), Thiering, E. (Elisabeth), Timpson, N. J. (Nicholas J.), Uitterlinden, A. G. (Andre G.), van Beijsterveldt, C. E. (Catharina E. M.), van Schaik, B. D. (Barbera D. C.), Vaudel, M. (Marc), Verduci, E. (Elvira), Vinding, R. K. (Rebecca K.), Vogel, M. (Mandy), Zeggini, E. (Eleftheria), Sebert, S. (Sylvain), Lind, M. V. (Mads V.), Brown, C. D. (Christopher D.), Santa-Marina, L. (Loreto), Reischl, E. (Eva), Frithioff-Bojsoe, C. (Christine), Meyre, D. (David), Wheeler, E. (Eleanor), Ong, K. (Ken), Nohr, E. A. (Ellen A.), Vrijkotte, T. G. (Tanja G. M.), Koppelman, G. H. (Gerard H.), Plomin, R. (Robert), Njolstad, P. R. (Pal R.), Dedoussis, G. D. (George D.), Froguel, P. (Philippe), Sorensen, T. I. (Thorkild I. A.), Jacobsson, B. (Bo), Freathy, R. M. (Rachel M.), Zemel, B. S. (Babette S.), Raitakari, O. (Olli), Vrijheid, M. (Martine), Feenstra, B. (Bjarke), Lyytikainen, L.-P. (Leo-Pekka), Snieder, H. (Harold), Kirsten, H. (Holger), Holt, P. G. (Patrick G.), Heinrich, J. (Joachim), Widen, E. (Elisabeth), Sunyer, J. (Jordi), Boomsma, D. I. (Dorret I.), Jarvelin, M.-R. (Marjo-Riitta), Koerner, A. (Antje), Davey Smith, G. (George), Holm, J.-C. (Jens-Christian), Atalay, M. (Mustafa), Murray, C. (Clare), Bisgaard, H. (Hans), McCarthy, M. I. (Mark I.), Jaddoe, V. W. (Vincent W. V.), Grant, S. F. (Struan F. A.), Felix, J. F. (Janine F.), Vogelezang, S. (Suzanne), Bradfield, J. P. (Jonathan P.), Ahluwalia, T. S. (Tarunveer S.), Curtin, J. A. (John A.), Lakka, T. A. (Timo A.), Grarup, N. (Niels), Scholz, M. (Markus), van der Most, P. J. (Peter J.), Monnereau, C. (Claire), Stergiakouli, E. (Evie), Heiskala, A. (Anni), Horikoshi, M. (Momoko), Fedko, I. O. (Iryna O.), Vilor-Tejedor, N. (Natalia), Cousminer, D. L. (Diana L.), Standl, M. (Marie), Wang, C. A. (Carol A.), Viikari, J. (Jorma), Geller, F. (Frank), iniguez, C. (Carmen), Pitkanen, N. (Niina), Chesi, A. (Alessandra), Bacelis, J. (Jonas), Yengo, L. (Loic), Torrent, M. (Maties), Ntalla, I. (Ioanna), Helgeland, O. (Oyvind), Selzam, S. (Saskia), Vonk, J. M. (Judith M.), Zafarmand, M. H. (Mohammed H.), Heude, B. (Barbara), Farooqi, I. S. (Ismaa Sadaf), Alyass, A. (Akram), Beaumont, R. N. (Robin N.), Have, C. T. (Christian T.), Rzehak, P. (Peter), Bilbao, J. R. (Jose Ramon), Schnurr, T. M. (Theresia M.), Barroso, I. (Ines), Bonnelykke, K. (Klaus), Beilin, L. J. (Lawrence J.), Carstensen, L. (Lisbeth), Charles, M.-A. (Marie-Aline), Chawes, B. (Bo), Clement, K. (Karine), Closa-Monasterolo, R. (Ricardo), Custovic, A. (Adnan), Eriksson, J. G. (Johan G.), Escribano, J. (Joaquin), Groen-Blokhuis, M. (Maria), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Hakonarson, H. (Hakon), Hansen, T. (Torben), Hattersley, A. T. (Andrew T.), Hollensted, M. (Mette), Hottenga, J.-J. (Jouke-Jan), Hypponen, E. (Elina), Johansson, S. (Stefan), Joro, R. (Raimo), Kahonen, M. (Mika), Karhunen, V. (Ville), Kiess, W. (Wieland), Knight, B. A. (Bridget A.), Koletzko, B. (Berthold), Kuehnapfel, A. (Andreas), Landgraf, K. (Kathrin), Langhendries, J.-P. (Jean-Paul), Lehtimaki, T. (Terho), Leinonen, J. T. (Jaakko T.), Li, A. (Aihuali), Lindi, V. (Virpi), Lowry, E. (Estelle), Bustamante, M. (Mariona), Medina-Gomez, C. (Carolina), Melbye, M. (Mads), Michaelsen, K. F. (Kim F.), Morgen, C. S. (Camilla S.), Mori, T. A. (Trevor A.), Nielsen, T. R. (Tenna R. H.), Niinikoski, H. (Harri), Oldehinkel, A. J. (Albertine J.), Pahkala, K. (Katja), Panoutsopoulou, K. (Kalliope), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Power, C. (Christine), Reijneveld, S. A. (Sijmen A.), Rivadeneira, F. (Fernando), Simpson, A. (Angela), Sly, P. D. (Peter D.), Stokholm, J. (Jakob), Teo, K. K. (Kook K.), Thiering, E. (Elisabeth), Timpson, N. J. (Nicholas J.), Uitterlinden, A. G. (Andre G.), van Beijsterveldt, C. E. (Catharina E. M.), van Schaik, B. D. (Barbera D. C.), Vaudel, M. (Marc), Verduci, E. (Elvira), Vinding, R. K. (Rebecca K.), Vogel, M. (Mandy), Zeggini, E. (Eleftheria), Sebert, S. (Sylvain), Lind, M. V. (Mads V.), Brown, C. D. (Christopher D.), Santa-Marina, L. (Loreto), Reischl, E. (Eva), Frithioff-Bojsoe, C. (Christine), Meyre, D. (David), Wheeler, E. (Eleanor), Ong, K. (Ken), Nohr, E. A. (Ellen A.), Vrijkotte, T. G. (Tanja G. M.), Koppelman, G. H. (Gerard H.), Plomin, R. (Robert), Njolstad, P. R. (Pal R.), Dedoussis, G. D. (George D.), Froguel, P. (Philippe), Sorensen, T. I. (Thorkild I. A.), Jacobsson, B. (Bo), Freathy, R. M. (Rachel M.), Zemel, B. S. (Babette S.), Raitakari, O. (Olli), Vrijheid, M. (Martine), Feenstra, B. (Bjarke), Lyytikainen, L.-P. (Leo-Pekka), Snieder, H. (Harold), Kirsten, H. (Holger), Holt, P. G. (Patrick G.), Heinrich, J. (Joachim), Widen, E. (Elisabeth), Sunyer, J. (Jordi), Boomsma, D. I. (Dorret I.), Jarvelin, M.-R. (Marjo-Riitta), Koerner, A. (Antje), Davey Smith, G. (George), Holm, J.-C. (Jens-Christian), Atalay, M. (Mustafa), Murray, C. (Clare), Bisgaard, H. (Hans), McCarthy, M. I. (Mark I.), Jaddoe, V. W. (Vincent W. V.), Grant, S. F. (Struan F. A.), and Felix, J. F. (Janine F.)

Abstract

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

Published
2020

7. The LifeCycle Project-EU Child Cohort Network:a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

Author

Jaddoe, V. W. (Vincent W. V.), Felix, J. F. (Janine F.), Andersen, A. N. (Anne‑Marie Nybo), Charles, M. (Marie‑Aline), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Donner, N. (Nina), Elhakeem, A. (Ahmed), Eriksson, J. G. (Johan G.), Foong, R. (Rachel), Grote, V. (Veit), Haakma, S. (Sido), Hanson, M. (Mark), Harris, J. R. (Jennifer R.), Heude, B. (Barbara), Huang, R. (Rae‑Chi), Inskip, H. (Hazel), Järvelin, M. (Marjo‑Riitta), Koletzko, B. (Berthold), Lawlor, D. A. (Deborah A.), Lindeboom, M. (Maarten), McEachan, R. R. (Rosemary R. C.), Mikkola, T. M. (Tuija M.), Nader, J. L. (Johanna L. T.), Pinot de Moira, A. (Angela), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Sebert, S. (Sylvain), Schwalber, A. (Ameli), Sunyer, J. (Jordi), Swertz, M. A. (Morris A.), Vafeiadi, M. (Marina), Vrijheid, M. (Martine), Wright, J. (John), Duijts, L. (Liesbeth), L. P. (LifeCycle Project Group), Jaddoe, V. W. (Vincent W. V.), Felix, J. F. (Janine F.), Andersen, A. N. (Anne‑Marie Nybo), Charles, M. (Marie‑Aline), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Donner, N. (Nina), Elhakeem, A. (Ahmed), Eriksson, J. G. (Johan G.), Foong, R. (Rachel), Grote, V. (Veit), Haakma, S. (Sido), Hanson, M. (Mark), Harris, J. R. (Jennifer R.), Heude, B. (Barbara), Huang, R. (Rae‑Chi), Inskip, H. (Hazel), Järvelin, M. (Marjo‑Riitta), Koletzko, B. (Berthold), Lawlor, D. A. (Deborah A.), Lindeboom, M. (Maarten), McEachan, R. R. (Rosemary R. C.), Mikkola, T. M. (Tuija M.), Nader, J. L. (Johanna L. T.), Pinot de Moira, A. (Angela), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Sebert, S. (Sylvain), Schwalber, A. (Ameli), Sunyer, J. (Jordi), Swertz, M. A. (Morris A.), Vafeiadi, M. (Marina), Vrijheid, M. (Martine), Wright, J. (John), Duijts, L. (Liesbeth), and L. P. (LifeCycle Project Group)

Abstract

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It

Published
2020

8. Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Author

Reese, S. E. (Sarah E.), Xu, C.-J. (Cheng-Jian), den Dekker, H. T. (Herman T.), Lee, M. K. (Mi Kyeong), Sikdar, S. (Sinjini), Ruiz-Arenas, C. (Carlos), Merid, S. K. (Simon K.), Rezwan, F. I. (Faisal I.), Page, C. M. (Christian M.), Ullemar, V. (Vilhelmina), Melton, P. E. (Phillip E.), Oh, S. S. (Sam S.), Yang, I. V. (Ivana V.), Burrows, K. (Kimberley), Söderhäll, C. (Cilla), Jima, D. D. (Dereje D.), Gao, L. (Lu), Arathimos, R. (Ryan), Küpers, L. K. (Leanne K.), Wielscher, M. (Matthias), Rzehak, P. (Peter), Lahti, J. (Jari), Laprise, C. (Catherine), Madore, A.-M. (Anne-Marie), Ward, J. (James), Bennett, B. D. (Brian D.), Wang, T. (Tianyuan), Bell, D. A. (Douglas A.), T. B. (The BIOS consortium), Vonk, J. M. (Judith M.), Håberg, S. E. (Siri E.), Zhao, S. (Shanshan), Karlsson, R. (Robert), Hollams, E. (Elysia), Hu, D. (Donglei), Richards, A. J. (Adam J.), Bergström, A. (Anna), Sharp, G. C. (Gemma C.), Felix, J. F. (Janine F.), Bustamante, M. (Mariona), Gruzieva, O. (Olena), Maguire, R. L. (Rachel L.), Gilliland, F. (Frank), Baïz, N. (Nour), Nohr, E. A. (Ellen A.), Corpeleijn, E. (Eva), Sebert, S. (Sylvain), Karmaus, W. (Wilfried), Grote, V. (Veit), Kajantie, E. (Eero), Magnus, M. C. (Maria C.), Örtqvist, A. K. (Anne K.), Eng, C. (Celeste), Liu, A. H. (Andrew H.), Kull, I. (Inger), Jaddoe, V. W. (Vincent W.V.), Sunyer, J. (Jordi), Kere, J. (Juha), Hoyo, C. (Cathrine), Annesi-Maesano, I. (Isabella), Arshad, S. H. (Syed Hasan), Koletzko, B. (Berthold), Brunekreef, B. (Bert), Binder, E. B. (Elisabeth B.), Räikkönen, K. (Katri), Reischl, E. (Eva), Holloway, J. W. (John W.), Järvelin, M.-R. (Marjo-Riitta), Snieder, H. (Harold), Kazmi, N. (Nabila), Breton, C. V. (Carrie V.), Murphy, S. K. (Susan K.), Pershagen, G. (Göran), Anto, J. M. (Josep Maria), Relton, C. L. (Caroline L.), Schwartz, D. A. (David A.), Burchard, E. G. (Esteban G.), Huang, R.-C. (Rae-Chi), Nystad, W. (Wenche), Almqvist, C. (Catarina), Henderson, A. J. (A. John), Melén, E. (Erik), Duijts, L. (Liesbeth), Koppelman, G. H. (Gerard H.), and London, S. J. (Stephanie J.)

Subjects
epigenetics, newborn, methylation, asthma, drug development, childhood
Abstract

Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion: Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.

Published
2019

9. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Santos, S. (Susana), Eekhout, I. (Iris), Voerman, E. (Ellis), Gaillard, R. (Romy), Barros, A.I. (Ana), Charles, M.A., Chatzi, L. (Leda), Chevrier, C. (Cécile), Chrousos, G.P. (George P.), Corpeleijn, W.E. (Willemijn), Costet, N. (Nathalie), Crozier, S. (Sarah), Doyon, M. (Myriam), Eggesbø, M. (Merete), Fantini, M.P. (Maria), Farchi, S. (Sara), Forastiere, F. (Francesco), Gagliardi, L. (Luigi), Georgiu, V. (Vagelis), Godfrey, K.M. (Keith M.), Gori, D. (Davide), Grote, V. (Veit), Hanke, W. (Wojciech), Hertz-Picciotto, I. (Irva), Heude, B. (Barbara), Hivert, M.-F. (Marie-France), Hryhorczuk, D.O. (Daniel), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Jusko, T.A. (Todd A), Karvonen, A.M. (Anne M.), Koletzko, B. (Berthold), Küpers, A.M. (Marlijn), Lagström, H. (Hanna), Lawlor, D.A. (Debbie A.), Lehmann, I. (Irina), Lopez-Espinosa, M.-J. (Maria-Jose), Magnus, P. (Per), Majewska, R. (Renata), Mäkelä, J. (Johanna), Manios, Y., McDonald, S.W. (Sheila W.), Mommers, M. (Monique), Morgen, C.S. (Camilla S.), Moschonis, G., Murinova, L.P. (Lubica Palkovicova), Newnham, J.P. (John), Nohr, C. (Christian), Andersen, A-M.N. (Anne-Marie Nybo), Oken, E. (Emily), Oostvogels, A.J.J.M. (Adriëtte J. J. M.), Pac, A. (Agnieszka), Papadopoulou, E. (Eleni), Pekkanen, J. (Juha), Pizzi, C. (Costanza), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Rifas-Shiman, S.L. (Sheryl), Roeleveld, N. (Nel), Santa-Marina, L. (Loreto), Santos, A.C. (Ana Cristina), Smit, H.A. (Henriëtte), Sørensen, T.I.A. (Thorkild), Standl, M. (Marie), Stanislawski, M. (Maggie), Stoltenberg, C. (Camilla), Thiering, E. (Elisabeth), Thijs, C. (Carel), Torrent, M. (Maties), Tough, S.C. (Suzanne C.), Trnovec, T. (Tomáš), Van Gelder, M.M.H.J. (Marleen M. H. J.), Rossem, L. (Lenie) van, Berg, A. (Andrea) von, Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Zvinchuk, O. (Oleksandr), Buuren, S. (Stef) van, Jaddoe, V.W.V. (Vincent), Santos, S. (Susana), Eekhout, I. (Iris), Voerman, E. (Ellis), Gaillard, R. (Romy), Barros, A.I. (Ana), Charles, M.A., Chatzi, L. (Leda), Chevrier, C. (Cécile), Chrousos, G.P. (George P.), Corpeleijn, W.E. (Willemijn), Costet, N. (Nathalie), Crozier, S. (Sarah), Doyon, M. (Myriam), Eggesbø, M. (Merete), Fantini, M.P. (Maria), Farchi, S. (Sara), Forastiere, F. (Francesco), Gagliardi, L. (Luigi), Georgiu, V. (Vagelis), Godfrey, K.M. (Keith M.), Gori, D. (Davide), Grote, V. (Veit), Hanke, W. (Wojciech), Hertz-Picciotto, I. (Irva), Heude, B. (Barbara), Hivert, M.-F. (Marie-France), Hryhorczuk, D.O. (Daniel), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Jusko, T.A. (Todd A), Karvonen, A.M. (Anne M.), Koletzko, B. (Berthold), Küpers, A.M. (Marlijn), Lagström, H. (Hanna), Lawlor, D.A. (Debbie A.), Lehmann, I. (Irina), Lopez-Espinosa, M.-J. (Maria-Jose), Magnus, P. (Per), Majewska, R. (Renata), Mäkelä, J. (Johanna), Manios, Y., McDonald, S.W. (Sheila W.), Mommers, M. (Monique), Morgen, C.S. (Camilla S.), Moschonis, G., Murinova, L.P. (Lubica Palkovicova), Newnham, J.P. (John), Nohr, C. (Christian), Andersen, A-M.N. (Anne-Marie Nybo), Oken, E. (Emily), Oostvogels, A.J.J.M. (Adriëtte J. J. M.), Pac, A. (Agnieszka), Papadopoulou, E. (Eleni), Pekkanen, J. (Juha), Pizzi, C. (Costanza), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Rifas-Shiman, S.L. (Sheryl), Roeleveld, N. (Nel), Santa-Marina, L. (Loreto), Santos, A.C. (Ana Cristina), Smit, H.A. (Henriëtte), Sørensen, T.I.A. (Thorkild), Standl, M. (Marie), Stanislawski, M. (Maggie), Stoltenberg, C. (Camilla), Thiering, E. (Elisabeth), Thijs, C. (Carel), Torrent, M. (Maties), Tough, S.C. (Suzanne C.), Trnovec, T. (Tomáš), Van Gelder, M.M.H.J. (Marleen M. H. J.), Rossem, L. (Lenie) van, Berg, A. (Andrea) von, Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Zvinchuk, O. (Oleksandr), Buuren, S. (Stef) van, and Jaddoe, V.W.V. (Vincent)

Abstract

Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy compli

Published
2018
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10. Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

Author

Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), London, S.J. (Stephanie J.), Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), and London, S.J. (Stephanie J.)

Published
2018
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11. Cohort profile:pregnancy and childhood epigenetics (PACE) consortium

Author

Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), London, S. J. (Stephanie J.), Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. 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Published
2018

12. Cultural effects on neurodevelopmental testing in children from six European countries: an analysis of NUTRIMENTHE Global Database

Author

Pérez-García, M. (Miguel), Luna, J.D.D. (Juan De Dios), Torres-Espínola, F.J. (Francisco J.), Martínez-Zaldívar, C. (Cristina), Anjos, T. (Tania), Graaf,, J.C. (Jurgen C. de), Weber, M. (Martina), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Verduci, E. (Elvira), Poncelet, P. (Pascale), Escribano, J. (Joaquín), Tiemeier, H.W. (Henning), Koletzko, B. (Berthold), Campoy, C. (Cristina), Pérez-García, M. (Miguel), Luna, J.D.D. (Juan De Dios), Torres-Espínola, F.J. (Francisco J.), Martínez-Zaldívar, C. (Cristina), Anjos, T. (Tania), Graaf,, J.C. (Jurgen C. de), Weber, M. (Martina), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Verduci, E. (Elvira), Poncelet, P. (Pascale), Escribano, J. (Joaquín), Tiemeier, H.W. (Henning), Koletzko, B. (Berthold), and Campoy, C. (Cristina)

Abstract

Cultural background is an important variable influencing neuropsychological performance. Multinational projects usually involve gath

Published
2017
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