Search

Your search keyword '"Grosso E."' showing total 646 results
Start Over Author "Grosso E."
646 results on '"Grosso E."'

3. 2D Recurrent Neural Networks for Robust Visual Tracking of Non-Rigid Bodies

Author

Masala, G. L., Golosio, B., Tistarelli, M., Grosso, E., Diniz Junqueira Barbosa, Simone, Series editor, Chen, Phoebe, Series editor, Du, Xiaoyong, Series editor, Filipe, Joaquim, Series editor, Kara, Orhun, Series editor, Kotenko, Igor, Series editor, Liu, Ting, Series editor, Sivalingam, Krishna M., Series editor, Washio, Takashi, Series editor, Jayne, Chrisina, editor, and Iliadis, Lazaros, editor

Published
2016
Full Text
View/download PDF

5. 29MO Germline variants NGS characterization in patients with non-syndromic adrenocortical carcinoma

Author

Grisanti, S., primary, Scatolini, M., additional, Tomaiuolo, P., additional, Grosso, E., additional, Basile, V., additional, Cosentini, D., additional, Puglisi, S., additional, Laganà, M., additional, Perotti, P., additional, Rossini, E., additional, Smussi, D., additional, Sigala, S., additional, Volante, M., additional, Berruti, A., additional, and Terzolo, M., additional

Published
2023
Full Text
View/download PDF

7. Copy number variants analysis in a cohort of isolated and syndromic developmental delay/intellectual disability reveals novel genomic disorders, position effects and candidate disease genes

Author

Di Gregorio, E., Riberi, E., Belligni, E.F., Biamino, E., Spielmann, M., Ala, U., Calcia, A., Bagnasco, I., Carli, D., Gai, G., Giordano, M., Guala, A., Keller, R., Mandrile, G., Arduino, C., Maffè, A., Naretto, V.G., Sirchia, F., Sorasio, L., Ungari, S., Zonta, A., Zacchetti, G., Talarico, F., Pappi, P., Cavalieri, S., Giorgio, E., Mancini, C., Ferrero, M., Brussino, A., Savin, E., Gandione, M., Pelle, A., Giachino, D.F., De Marchi, M., Restagno, G., Provero, P., Cirillo Silengo, M., Grosso, E., Buxbaum, J.D., Pasini, B., De Rubeis, S., Brusco, A., and Ferrero, G.B.

Published
2017
Full Text
View/download PDF

10. GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma

Author

Scatolini, M., primary, Patel, A., additional, Grosso, E., additional, Mello-Grand, M., additional, Ostano, P., additional, Coppo, R., additional, Vitiello, M., additional, Venesio, T., additional, Zaccagna, A., additional, Pisacane, A., additional, Sarotto, I., additional, Taverna, D., additional, Poliseno, L., additional, Bergamaschi, D., additional, and Chiorino, G., additional

Published
2022
Full Text
View/download PDF

11. Expanding the clinical phenotype of the ultra-rare Skraban-Deardorff syndrome: Two novel individuals with WDR26 loss-of-function variants and a literature review

Author

Pavinato, L., Trajkova, S., Grosso, E., Giorgio, E., Bruselles, A., Radio, F. C., Pippucci, T., Dimartino, P., Tartaglia, M., Petlichkovski, A., De Rubeis, S., Buxbaum, J., Ferrero, G. B., Keller, R., and Brusco, A.

Subjects
Adult, Male, autism spectrum disorder, epilepsy, intellectual disability, Skraban-Deardorff, WDR26, Haploinsufficiency, Phenotype, Neurodevelopmental Disorders, Child, Preschool, Intellectual Disability, Mutation, Humans, Female, Genetic Predisposition to Disease, Chromosome Deletion, Child, Adaptor Proteins, Signal Transducing
Abstract

De novo variants in the WDR26 gene leading to haploinsufficiency have recently been associated with Skraban-Deardorff syndrome. This condition is an ultra-rare autosomal dominant neurodevelopmental disorder characterized by a broad range of clinical signs, including intellectual disability (ID), developmental delay (DD), seizures, abnormal facial features, feeding difficulties, and minor skeletal anomalies. Currently, 18 cases have been reported in the literature and for only 15 of them a clinical description is available. Here, we describe a child with Skraban-Deardorff syndrome associated with the WDR26 pathogenic de novo variant NM_025160.6:c.69dupC, p.(Gly24ArgfsTer48), and an adult associated with the pathogenic de novo variant c.1076G A, p.(Trp359Ter). The adult patient was a 29-year-old female with detailed information on clinical history and pharmacological treatments since birth, providing an opportunity to map disease progression and patient management. By comparing our cases with published reports of Skraban-Deardorff syndrome, we provide a genetic and clinical summary of this ultrarare condition, describe the clinical management from childhood to adult age, and further expand on the clinical phenotype.

Published
2021

16. Understanding and modeling visitor behaviours for enhancing personalized cultural experiences

Author

Pandolfo, L, Spanu, S, Grosso, E, Pulina, L, Pandolfo, L, Spanu, S, Grosso, E, and Pulina, L

Abstract

Nowadays, there is an increasing interest in using adaptive technologies in cultural heritage sites to personalize and enhance the user's visit experience. However, personalizing the cultural experiences is still a challenging task that requires a deep knowledge of those user aspects that influence the visit. In order to facilitate the learning process during the visit, adaptive systems should consider differences between individuals for personalizing access to cultural heritage collections. This article calls into question the role that technologies can play both to enhance a user's visit experience and to attract new audiences through personalized interactions with cultural objects. It addresses a specific understanding of visitors' needs and behaviours by means of empirical data collected through a survey questionnaire. Knowing the main factors underlying visitors' styles it allowed formalization of this knowledge into a user model ontology which collects the main visitors' characteristics in the use of cultural heritage contexts.

Published
2020

19. AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Author

Salpietro, V. Dixon, C.L. Guo, H. Bello, O.D. Vandrovcova, J. Efthymiou, S. Maroofian, R. Heimer, G. Burglen, L. Valence, S. Torti, E. Hacke, M. Rankin, J. Tariq, H. Colin, E. Procaccio, V. Striano, P. Mankad, K. Lieb, A. Chen, S. Pisani, L. Bettencourt, C. Männikkö, R. Manole, A. Brusco, A. Grosso, E. Ferrero, G.B. Armstrong-Moron, J. Gueden, S. Bar-Yosef, O. Tzadok, M. Monaghan, K.G. Santiago-Sim, T. Person, R.E. Cho, M.T. Willaert, R. Yoo, Y. Chae, J.-H. Quan, Y. Wu, H. Wang, T. Bernier, R.A. Xia, K. Blesson, A. Jain, M. Motazacker, M.M. Jaeger, B. Schneider, A.L. Boysen, K. Muir, A.M. Myers, C.T. Gavrilova, R.H. Gunderson, L. Schultz-Rogers, L. Klee, E.W. Dyment, D. Osmond, M. Parellada, M. Llorente, C. Gonzalez-Peñas, J. Carracedo, A. Van Haeringen, A. Ruivenkamp, C. Nava, C. Heron, D. Nardello, R. Iacomino, M. Minetti, C. Skabar, A. Fabretto, A. Hanna, M.G. Bugiardini, E. Hostettler, I. O’Callaghan, B. Khan, A. Cortese, A. O’Connor, E. Yau, W.Y. Bourinaris, T. Kaiyrzhanov, R. Chelban, V. Madej, M. Diana, M.C. Vari, M.S. Pedemonte, M. Bruno, C. Balagura, G. Scala, M. Fiorillo, C. Nobili, L. Malintan, N.T. Zanetti, M.N. Krishnakumar, S.S. Lignani, G. Jepson, J.E.C. Broda, P. Baldassari, S. Rossi, P. Fruscione, F. Madia, F. Traverso, M. De-Marco, P. Pérez-Dueñas, B. Munell, F. Kriouile, Y. El-Khorassani, M. Karashova, B. Avdjieva, D. Kathom, H. Tincheva, R. Van-Maldergem, L. Nachbauer, W. Boesch, S. Gagliano, A. Amadori, E. Goraya, J.S. Sultan, T. Kirmani, S. Ibrahim, S. Jan, F. Mine, J. Banu, S. Veggiotti, P. Zuccotti, G.V. Ferrari, M.D. Van Den Maagdenberg, A.M.J. Verrotti, A. Marseglia, G.L. Savasta, S. Soler, M.A. Scuderi, C. Borgione, E. Chimenz, R. Gitto, E. Dipasquale, V. Sallemi, A. Fusco, M. Cuppari, C. Cutrupi, M.C. Ruggieri, M. Cama, A. Capra, V. Mencacci, N.E. Boles, R. Gupta, N. Kabra, M. Papacostas, S. Zamba-Papanicolaou, E. Dardiotis, E. Maqbool, S. Rana, N. Atawneh, O. Lim, S.Y. Shaikh, F. Koutsis, G. Breza, M. Coviello, D.A. Dauvilliers, Y.A. AlKhawaja, I. AlKhawaja, M. Al-Mutairi, F. Stojkovic, T. Ferrucci, V. Zollo, M. Alkuraya, F.S. Kinali, M. Sherifa, H. Benrhouma, H. Turki, I.B.Y. Tazir, M. Obeid, M. Bakhtadze, S. Saadi, N.W. Zaki, M.S. Triki, C.C. Benfenati, F. Gustincich, S. Kara, M. Belcastro, V. Specchio, N. Capovilla, G. Karimiani, E.G. Salih, A.M. Okubadejo, N.U. Ojo, O.O. Oshinaike, O.O. Oguntunde, O. Wahab, K. Bello, A.H. Abubakar, S. Obiabo, Y. Nwazor, E. Ekenze, O. Williams, U. Iyagba, A. Taiwo, L. Komolafe, M. Senkevich, K. Shashkin, C. Zharkynbekova, N. Koneyev, K. Manizha, G. Isrofilov, M. Guliyeva, U. Salayev, K. Khachatryan, S. Rossi, S. Silvestri, G. Haridy, N. Ramenghi, L.A. Xiromerisiou, G. David, E. Aguennouz, M. Fidani, L. Spanaki, C. Tucci, A. Raspall-Chaure, M. Chez, M. Tsai, A. Fassi, E. Shinawi, M. Constantino, J.N. De Zorzi, R. Fortuna, S. Kok, F. Keren, B. Bonneau, D. Choi, M. Benzeev, B. Zara, F. Mefford, H.C. Scheffer, I.E. Clayton-Smith, J. Macaya, A. Rothman, J.E. Eichler, E.E. Kullmann, D.M. Houlden, H. SYNAPS Study Group

Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission. © 2019, The Author(s).

Published
2019

24. Performance analysis of data fragmentation techniques on a cloud server

Author

Santos, N, Lentini, S, Grosso, E, Ghita, B, Masala, G, Santos, N, Lentini, S, Grosso, E, Ghita, B, and Masala, G

Abstract

Copyright © 2019 Inderscience Enterprises Ltd. The advancements in virtualisation and distributed computing have allowed the cloud paradigm to become very popular among users and resources. It allows companies to save costs on infrastructure and maintenance and to focus on the development of products. However, this fast-growing paradigm has brought along some concerns from users, such as the integrity and security of the data, particularly in environments where users rely entirely on providers to secure their data. This paper explores different techniques to fragment data on the cloud and prevent direct unauthorised access to the data. It explores their performance on a cloud instance, where the total time to perform the operation, including the upload and download of the data, is considered. Results from this experiment indicate that fragmentation algorithms show better performance compared to encryption. Moreover, when combining encryption with fragmentation, there is an increase in the security, with the trade-off of the performance.

Published
2019

25. AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Author

Salpietro, V, Dixon, CL, Guo, H, Bello, OD, Vandrovcova, J, Efthymiou, S, Maroofian, R, Heimer, G, Burglen, L, Valence, S, Torti, E, Hacke, M, Rankin, J, Tariq, H, Colin, E, Procaccio, V, Striano, P, Mankad, K, Lieb, A, Chen, S, Pisani, L, Bettencourt, C, Mannikko, R, Manole, A, Brusco, A, Grosso, E, Ferrero, GB, Armstrong-Moron, J, Gueden, S, Bar-Yosef, O, Tzadok, M, Monaghan, KG, Santiago-Sim, T, Person, RE, Cho, MT, Willaert, R, Yoo, Y, Chae, J-H, Quan, Y, Wu, H, Wang, T, Bernier, RA, Xia, K, Blesson, A, Jain, M, Motazacker, MM, Jaeger, B, Schneider, AL, Boysen, K, Muir, AM, Myers, CT, Gavrilova, RH, Gunderson, L, Schultz-Rogers, L, Klee, EW, Dyment, D, Osmond, M, Parellada, M, Llorente, C, Gonzalez-Penas, J, Carracedo, A, Van Haeringen, A, Ruivenkamp, C, Nava, C, Heron, D, Nardello, R, Iacomino, M, Minetti, C, Skabar, A, Fabretto, A, Chez, M, Tsai, A, Fassi, E, Shinawi, M, Constantino, JN, De Zorzi, R, Fortuna, S, Kok, F, Keren, B, Bonneau, D, Choi, M, Benzeev, B, Zara, F, Mefford, HC, Scheffer, IE, Clayton-Smith, J, Macaya, A, Rothman, JE, Eichler, EE, Kullmann, DM, Houlden, H, Raspall-Chaure, M, Hanna, MG, Bugiardini, E, Hostettler, I, O'Callaghan, B, Khan, A, Cortese, A, O'Connor, E, Yau, WY, Bourinaris, T, Kaiyrzhanov, R, Chelban, V, Madej, M, Diana, MC, Vari, MS, Pedemonte, M, Bruno, C, Balagura, G, Scala, M, Fiorillo, C, Nobili, L, Malintan, NT, Zanetti, MN, Krishnakumar, SS, Lignani, G, Jepson, JEC, Broda, P, Baldassari, S, Rossi, P, Fruscione, F, Madia, F, Traverso, M, De-Marco, P, Perez-Duenas, B, Munell, F, Kriouile, Y, El-Khorassani, M, Karashova, B, Avdjieva, D, Kathom, H, Tincheva, R, Van-Maldergem, L, Nachbauer, W, Boesch, S, Gagliano, A, Amadori, E, Goraya, JS, Sultan, T, Kirmani, S, Ibrahim, S, Jan, F, Mine, J, Banu, S, Veggiotti, P, Zuccotti, G, Ferrari, MD, Van Den Maagdenberg, AMJ, Verrotti, A, Marseglia, GL, Savasta, S, Soler, MA, Scuderi, C, Borgione, E, Chimenz, R, Gitto, E, Dipasquale, V, Sallemi, A, Fusco, M, Cuppari, C, Cutrupi, MC, Ruggieri, M, Cama, A, Capra, V, Mencacci, NE, Boles, R, Gupta, N, Kabra, M, Papacostas, S, Zamba-Papanicolaou, E, Dardiotis, E, Maqbool, S, Rana, N, Atawneh, O, Lim, SY, Shaikh, F, Koutsis, G, Breza, M, Coviello, DA, Dauvilliers, YA, AlKhawaja, I, AlKhawaja, M, Al-Mutairi, F, Stojkovic, T, Ferrucci, V, Zollo, M, Alkuraya, FS, Kinali, M, Sherifa, H, Benrhouma, H, Turki, IBY, Tazir, M, Obeid, M, Bakhtadze, S, Saadi, NW, Zaki, MS, Triki, CC, Benfenati, F, Gustincich, S, Kara, M, Belcastro, V, Specchio, N, Capovilla, G, Karimiani, EG, Salih, AM, Okubadejo, NU, Ojo, OO, Oshinaike, OO, Oguntunde, O, Wahab, K, Bello, AH, Abubakar, S, Obiabo, Y, Nwazor, E, Ekenze, O, Williams, U, Iyagba, A, Taiwo, L, Komolafe, M, Senkevich, K, Shashkin, C, Zharkynbekova, N, Koneyev, K, Manizha, G, Isrofilov, M, Guliyeva, U, Salayev, K, Khachatryan, S, Rossi, S, Silvestri, G, Haridy, N, Ramenghi, LA, Xiromerisiou, G, David, E, Aguennouz, M, Fidani, L, Spanaki, C, Tucci, A, Salpietro, V, Dixon, CL, Guo, H, Bello, OD, Vandrovcova, J, Efthymiou, S, Maroofian, R, Heimer, G, Burglen, L, Valence, S, Torti, E, Hacke, M, Rankin, J, Tariq, H, Colin, E, Procaccio, V, Striano, P, Mankad, K, Lieb, A, Chen, S, Pisani, L, Bettencourt, C, Mannikko, R, Manole, A, Brusco, A, Grosso, E, Ferrero, GB, Armstrong-Moron, J, Gueden, S, Bar-Yosef, O, Tzadok, M, Monaghan, KG, Santiago-Sim, T, Person, RE, Cho, MT, Willaert, R, Yoo, Y, Chae, J-H, Quan, Y, Wu, H, Wang, T, Bernier, RA, Xia, K, Blesson, A, Jain, M, Motazacker, MM, Jaeger, B, Schneider, AL, Boysen, K, Muir, AM, Myers, CT, Gavrilova, RH, Gunderson, L, Schultz-Rogers, L, Klee, EW, Dyment, D, Osmond, M, Parellada, M, Llorente, C, Gonzalez-Penas, J, Carracedo, A, Van Haeringen, A, Ruivenkamp, C, Nava, C, Heron, D, Nardello, R, Iacomino, M, Minetti, C, Skabar, A, Fabretto, A, Chez, M, Tsai, A, Fassi, E, Shinawi, M, Constantino, JN, De Zorzi, R, Fortuna, S, Kok, F, Keren, B, Bonneau, D, Choi, M, Benzeev, B, Zara, F, Mefford, HC, Scheffer, IE, Clayton-Smith, J, Macaya, A, Rothman, JE, Eichler, EE, Kullmann, DM, Houlden, H, Raspall-Chaure, M, Hanna, MG, Bugiardini, E, Hostettler, I, O'Callaghan, B, Khan, A, Cortese, A, O'Connor, E, Yau, WY, Bourinaris, T, Kaiyrzhanov, R, Chelban, V, Madej, M, Diana, MC, Vari, MS, Pedemonte, M, Bruno, C, Balagura, G, Scala, M, Fiorillo, C, Nobili, L, Malintan, NT, Zanetti, MN, Krishnakumar, SS, Lignani, G, Jepson, JEC, Broda, P, Baldassari, S, Rossi, P, Fruscione, F, Madia, F, Traverso, M, De-Marco, P, Perez-Duenas, B, Munell, F, Kriouile, Y, El-Khorassani, M, Karashova, B, Avdjieva, D, Kathom, H, Tincheva, R, Van-Maldergem, L, Nachbauer, W, Boesch, S, Gagliano, A, Amadori, E, Goraya, JS, Sultan, T, Kirmani, S, Ibrahim, S, Jan, F, Mine, J, Banu, S, Veggiotti, P, Zuccotti, G, Ferrari, MD, Van Den Maagdenberg, AMJ, Verrotti, A, Marseglia, GL, Savasta, S, Soler, MA, Scuderi, C, Borgione, E, Chimenz, R, Gitto, E, Dipasquale, V, Sallemi, A, Fusco, M, Cuppari, C, Cutrupi, MC, Ruggieri, M, Cama, A, Capra, V, Mencacci, NE, Boles, R, Gupta, N, Kabra, M, Papacostas, S, Zamba-Papanicolaou, E, Dardiotis, E, Maqbool, S, Rana, N, Atawneh, O, Lim, SY, Shaikh, F, Koutsis, G, Breza, M, Coviello, DA, Dauvilliers, YA, AlKhawaja, I, AlKhawaja, M, Al-Mutairi, F, Stojkovic, T, Ferrucci, V, Zollo, M, Alkuraya, FS, Kinali, M, Sherifa, H, Benrhouma, H, Turki, IBY, Tazir, M, Obeid, M, Bakhtadze, S, Saadi, NW, Zaki, MS, Triki, CC, Benfenati, F, Gustincich, S, Kara, M, Belcastro, V, Specchio, N, Capovilla, G, Karimiani, EG, Salih, AM, Okubadejo, NU, Ojo, OO, Oshinaike, OO, Oguntunde, O, Wahab, K, Bello, AH, Abubakar, S, Obiabo, Y, Nwazor, E, Ekenze, O, Williams, U, Iyagba, A, Taiwo, L, Komolafe, M, Senkevich, K, Shashkin, C, Zharkynbekova, N, Koneyev, K, Manizha, G, Isrofilov, M, Guliyeva, U, Salayev, K, Khachatryan, S, Rossi, S, Silvestri, G, Haridy, N, Ramenghi, LA, Xiromerisiou, G, David, E, Aguennouz, M, Fidani, L, Spanaki, C, and Tucci, A

Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

Published
2019

28. ESTRATÉGIAS E DESDOBRAMENTOS DE UMA URBANIZAÇÃO OLIGOPOLISTA EM PRIMAVERA DO LESTE, MATO GROSSO, BRASIL / STRATEGIES AND CONSEQUENCES OF AN OLIGOPOLISTIC URBANIZATION IN PRIMAVERA DO LESTE, MATO GROSSO, BRAZIL

Author

Fioravanti, Lívia Maschio and Docente do IFMT (Instituto Federal de Mato Grosso) e doutoranda em Geografia Humana na Universidade de São Paulo

Abstract

O objetivo deste trabalho é investigar de que modo o início da ocupação de Primavera do Leste influencia em seus atuais conflitos espaciais. O modo pelo qual a propriedade rural foi dominada e fracionada por grandes empresários do centro-sul brasileiro nas últimas três décadas do século XX teve como consequência uma dominação também da propriedade urbana, culminando em uma “urbanização oligopolista”. Por meio de levantamento bibliográfico e realização de trabalhos de campo, demonstramos que essas famílias pioneiras empregam diversas estratégias para controlar a renda da terra e a valorização do solo urbano.

Published
2018

30. 476 GJB5 association with BRAF mutation and survival in cutaneous melanoma

Author

Scatolini, M., primary, Grosso, E., additional, Mello-Grand, M., additional, Ostano, P., additional, Coppo, R., additional, Patel, A., additional, Vitiello, M., additional, Venesio, T., additional, Zaccagna, A., additional, Pisacane, A., additional, Sarotto, I., additional, Taverna, D., additional, Poliseno, L., additional, Chiorino, G., additional, and Bergamaschi, D., additional

Published
2019
Full Text
View/download PDF

31. 2D recurrent neural networks: a high-performance tool for robust visual tracking in dynamic scenes

Author

Masala, G, Casu, F, Golosio, B, Grosso, E, Masala, G, Casu, F, Golosio, B, and Grosso, E

Abstract

© 2017, The Natural Computing Applications Forum. This paper proposes a novel method for robust visual tracking of arbitrary objects, based on the combination of image-based prediction and position refinement by weighted correlation. The effectiveness of the proposed approach is demonstrated on a challenging set of dynamic video sequences, extracted from the final of triple jump at the London 2012 Summer Olympics. A comparison is made against five baseline tracking systems. The novel system shows remarkable superior performances with respect to the other methods, in all considered cases characterized by changing background, and a large variety of articulated motions. The novel architecture, from here onward named 2D Recurrent Neural Network (2D-RNN), is derived from the well-known recurrent neural network model and adopts nearest neighborhood connections between the input and context layers in order to store the temporal information content of the video. Starting from the selection of the object of interest in the first frame, neural computation is applied to predict the position of the target in each video frame. Normalized cross-correlation is then applied to refine the predicted target position. 2D-RNN ensures limited complexity, great adaptability and a very fast learning time. At the same time, it shows on the considered dataset fast execution times and very good accuracy, making this approach an excellent candidate for automated analysis of complex video streams.

Published
2018

32. Biometric authentication and data security in cloud computing

Author

Masala, G.L., Ruiu, P., Grosso, E., Masala, G.L., Ruiu, P., and Grosso, E.

Abstract

Two important topics related to the cloud security are discussed in this chapter: the authentication of logical users accessing the cloud, and the security of data stored on public cloud servers. A real cloud platform is used as example; it is designed and implemented to support basic web applications, and to be shared by small and medium companies. Such platform is built using the OpenStack architecture. The user authentication is based on an original biometric approach exploiting fingerprints and open to multimodal improvements. The platform guarantees secure access of multiple users and complete logical separation of computational and data resources, related to different companies. High level of protection of the data, stored in the cloud, is ensured by adopting a peculiar data fragmentation approach. Details are given about the authentication process and of the service modules involved in the biometric authentication. Furthermore are discussed the key issues, related to the integration of the biometric authentication, in the cloud platform.

Published
2018

33. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)

Author

Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Bassi I., Moro M., Pincelli A. I., Mancini A. (ORCID:0000-0002-7707-4564), Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M. (ORCID:0000-0001-5767-8785), Grugni G., Parenti G., Pontecorvi A. (ORCID:0000-0003-0570-6865), Sala E., Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Bassi I., Moro M., Pincelli A. I., Mancini A. (ORCID:0000-0002-7707-4564), Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M. (ORCID:0000-0001-5767-8785), Grugni G., Parenti G., Pontecorvi A. (ORCID:0000-0003-0570-6865), and Sala E.

Abstract

Objective: Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and nonreproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. Design: Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. Methods: We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). Results: 90% of patients were classifed as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was signifcantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann's syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are signifcantly associated with AO-IHH rather than PPO-IHH. Conclusions: Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these fndings improve the understanding of IHH and may have a positive impact on the management of patients and their families.

Published
2018

35. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)

Author

Bonomi, Marco, primary, Vezzoli, Valeria, additional, Krausz, Csilla, additional, Guizzardi, Fabiana, additional, Vezzani, Silvia, additional, Simoni, Manuela, additional, Bassi, Ivan, additional, Duminuco, Paolo, additional, Di Iorgi, Natascia, additional, Giavoli, Claudia, additional, Pizzocaro, Alessandro, additional, Russo, Gianni, additional, Moro, Mirella, additional, Fatti, Letizia, additional, Ferlin, Alberto, additional, Mazzanti, Laura, additional, Zatelli, Maria Chiara, additional, Cannavò, Salvo, additional, Isidori, Andrea M, additional, Pincelli, Angela Ida, additional, Prodam, Flavia, additional, Mancini, Antonio, additional, Limone, Paolo, additional, Tanda, Maria Laura, additional, Gaudino, Rossella, additional, Salerno, Mariacarolina, additional, Francesca, Pregnolato, additional, Maghnie, Mohamad, additional, Maggi, Mario, additional, Persani, Luca, additional, _, _, additional, Aimaretti, G, additional, Altobelli, M, additional, Ambrosio, M R, additional, Andrioli, M, additional, Angeletti, G, additional, Arecco, F, additional, Arnaldi, G, additional, Arosio, M, additional, Balsamo, A, additional, Baldassarri, M, additional, Bartalena, L, additional, Bazzoni, N, additional, Beccaria, L, additional, Beck-Peccoz, P, additional, Bellastella, G, additional, Bellizzi, M, additional, Benedicenti, F, additional, Bernasconi, S, additional, Bizzarri, C, additional, Bona, G, additional, Bonadonna, S, additional, Borretta, G, additional, Boschetti, M, additional, Brunani, A, additional, Brunelli, V, additional, Buzi, F, additional, Cacciatore, C, additional, Cangiano, B, additional, Cappa, M, additional, Casalone, R, additional, Cassio, A, additional, Cavarzere, P, additional, Cherubini, V, additional, Ciampani, T, additional, Cicognani, D, additional, Cignarelli, A, additional, Cisternino, M, additional, Colombo, P, additional, Corbetta, S, additional, Corciulo, N, additional, Corona, G, additional, Cozzi, R, additional, Crivellaro, C, additional, Dalle Mule, I, additional, Danesi, L, additional, D’Elia, A V, additional, degli Uberti, E, additional, De Leo, S, additional, Della Valle, E, additional, De Marchi, M, additional, Di Iorgi, N, additional, Di Mambro, A, additional, Fabbri, A, additional, Foresta, C, additional, Forti, G, additional, Franceschi, A R, additional, Garolla, A, additional, Ghezzi, M, additional, Giacomozzi, C, additional, Giusti, M, additional, Grosso, E, additional, Guabello, G, additional, Guarneri, M P, additional, Grugni, G, additional, Isidori, A M, additional, Lanfranco, F, additional, Lania, A, additional, Lanzi, R, additional, Larizza, L, additional, Lenzi, A, additional, Loche, S, additional, Loli, P, additional, Lombardi, V, additional, Maggio, M C, additional, Mandrile, G, additional, Manieri, C, additional, Mantovani, G, additional, Marelli, S, additional, Marzullo, M, additional, Mencarelli, M A, additional, Migone, N, additional, Motta, G, additional, Neri, G, additional, Padova, G, additional, Parenti, G, additional, Pasquino, B, additional, Pia, A, additional, Piantanida, E, additional, Pignatti, E, additional, Pilotta, A, additional, Pivetta, B, additional, Pollazzon, M, additional, Pontecorvi, A, additional, Porcelli, P, additional, Pozzan, G B, additional, Pozzobon, G, additional, Radetti, G, additional, Razzore, P, additional, Rocchetti, L, additional, Roncoroni, R, additional, Rossi, G, additional, Sala, E, additional, Salvatoni, A, additional, Salvini, F, additional, Secco, A, additional, Segni, M, additional, Selice, R, additional, Sgaramella, P, additional, Sileo, F, additional, Sinisi, A A, additional, Sirchia, F, additional, Spada, A, additional, Tresoldi, A, additional, Vigneri, R, additional, Weber, G, additional, and Zucchini, S, additional

Published
2018
Full Text
View/download PDF

37. Biometric authentication and data security in cloud computing

Author

Daimi, Kevin, Masala, GL, Ruiu, P, Grosso, E, Daimi, Kevin, Masala, GL, Ruiu, P, and Grosso, E

Abstract

Two important topics related to the cloud security are discussed in this chapter: the authentication of logical users accessing the cloud, and the security of data stored on public cloud servers. A real cloud platform is used as example; it is designed and implemented to support basic web applications, and to be shared by small and medium companies. Such platform is built using the OpenStack architecture. The user authentication is based on an original biometric approach exploiting fingerprints and open to multimodal improvements. The platform guarantees secure access of multiple users and complete logical separation of computational and data resources, related to different companies. High level of protection of the data, stored in the cloud, is ensured by adopting a peculiar data fragmentation approach. Details are given about the authentication process and of the service modules involved in the biometric authentication. Furthermore are discussed the key issues, related to the integration of the biometric authentication, in the cloud platform.

Published
2017

38. Teleradiology through iPad May Positively Affects the Quality of Health Care in a Paediatric Children Hospital

Author

ZENNARO, FLORIANA, DEMARINI, SERGIO, CONT, GABRIELE, GUASTALLA, PIERPAOLO, BELGRANO, MANUEL GIANVALERIO, ODONI, LUCA, DIBELLO, DANIELA, LAZZERINI, MARZIA, Vittoria, Francesca, Dicarlo, Valentina, Barbo, Giuliano, Steinbock, Antonella, Daniele Grosso, E, RSNA, Zennaro, Floriana, Demarini, Sergio, Cont, Gabriele, Guastalla, Pierpaolo, Vittoria, Francesca, Belgrano, MANUEL GIANVALERIO, Odoni, Luca, Dicarlo, Valentina, Dibello, Daniela, Barbo, Giuliano, Steinbock, Antonella, Daniele Grosso, E, and Lazzerini, Marzia

Subjects
Pediatric teleradiology
Published
2014

39. Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)-Chlorooximes, lsocyanides, and Electron-Deficient Phenols

Author

Mercalli V., Del Grosso E., Varese M., Massarotti A., Tront G.C., GIUSTINIANO, MARIATERESA, CASSESE, HILDE, NOVELLINO, ETTORE, Mercalli, V., Giustiniano, Mariateresa, Del Grosso, E., Varese, M., Cassese, Hilde, Massarotti, A., Novellino, Ettore, and Tront, G. C.

Subjects
multicomponent reactions, isocyanides, (Z)-chlorooximes, aryloxyiminoamides, benzo[d]isoxazole-3-carboxamides
Abstract

A library of 41 aryloxyimino amides was prepared via solution phase parallel synthesis by extending the multicomponent reaction of (Z)-chlorooximes and isocyanides to the use of electron-deficient phenols. The resulting aryloxyiminoamide derivatives can be used as intermediates for the synthesis of benzo[d]isoxazole-3-carboxamides, dramatically reducing the number of synthetic steps required by other methods reported in literature.

Published
2014

40. Identification of patients at high risk for hypocalcemia after total thyroidectomy

Author

TREDICI, P., GROSSO, E., GIBELLI, B., MASSARO, M.A., ARRIGONI, C., and TRADATI, N.

Subjects
Oncology, Hypocalcemia, Risk Factors, Thyroidectomy, Humans, Calcium therapy, Prospective Studies, Retrospective Studies
Abstract

SUMMARY Hypocalcemia is a major post-operative complication of total thyroidectomy, causing severe symptoms and increasing hospitalization time. The primary cause is secondary hypo-parathyroidism following damage to, or devascularisation of, one or more parathyroid glands during surgery. Aim of the study was to develop a simple and reliable method for predicting post-operative hypocalcemia in total thyroidectomy patients. A retrospective analysis was made of immediate pre-operative and early post-operative calcium levels in 100 patients. It was found that a marked decrease in blood calcium, immediately after surgery, was a sensitive predictor of hypocalcemia. In a subsequent prospective series of 67 patients, the efficacy was assessed of early administration of calcium plus Vitamin D in reducing symptomatic hypocalcemia in patients in whom the difference (Δ) between pre- and post-operative blood calcium was ≥ 1.1 mg/dl. This treatment was part of a protocol in which normo-calcemic patients were discharged immediately after drainage removal (third post-operative day). In the retrospective series, 84% of patients who developed hypocalcemia had Δ ≥ 1.1 and 54% of patients who did not develop hypocalcemia had Δ < 1.1 (p < 0.0001). Mean duration of hospitalization was 6.2 days. In the prospective series, 76% of patients who developed hypocalcemia had Δ ≥ 1.1 mg/dl; of the patients who did not develop hypocalcemia 75% had Δ < 1.1 mg/dl (p = 0.0013); mean hospitalization was 4.7 days (p < 0.0001). Use of the 1.1 mg/dl cut-off for deciding whether to start early prophylaxis allowed most patients to avoid symptomatic hypocalcemia (and the associated anxiety), while permitting a significantly reduced hospital stay, resulting in lower hospitalization costs.

Published
2011

41. 18FDG PET/CT Image-Guided Simultaneous Integrated Boost Intensity-Modulated Radiotherapy in Head and Neck cancer

Author

Mapelli, P, Grosso, E, Dell'Oca, I, Kirienko, M, Castiglioni, I, Villa, E, Gianolli, L, Picchio, M, Messa, C, Mapelli P, Grosso E, Dell'Oca I, Kirienko M, CASTIGLIONI I, Villa E, Gianolli L, Picchio M, Messa C, Mapelli, P, Grosso, E, Dell'Oca, I, Kirienko, M, Castiglioni, I, Villa, E, Gianolli, L, Picchio, M, Messa, C, Mapelli P, Grosso E, Dell'Oca I, Kirienko M, CASTIGLIONI I, Villa E, Gianolli L, Picchio M, and Messa C

Published
2012

42. A Decision Support System for the assisted diagnosis of brain tumors: a feasibility study for ¹⁸F-FDG PET preclinical studies

Author

Grosso, E, Lopez, M, SALVATORE, CHRISTIAN, Gallivanone, F, Di Grigoli, G, Valtorta, Silvia, MORESCO, ROSA MARIA, GILARDI, MARIA CARLA, Ramirez, J, Gorriz, JM, Castiglioni, I., Grosso, E, Lopez, M, Salvatore, C, Gallivanone, F, Di Grigoli, G, Valtorta, S, Moresco, R, Gilardi, M, Ramirez, J, Gorriz, J, and Castiglioni, I

Subjects
Principal Component Analysis, Brain Neoplasms, Fluorodeoxyglucose F18, Positron-Emission Tomography, Disease Progression, Machine learning, PET, brain, tumor, preclinical, Decision Support System, Humans, Decision Support Systems, Clinical, Sensitivity and Specificity, Algorithms
Abstract

Decision support systems for the assisted medical diagnosis offer the main feature of giving assessments which are poorly affected from arbitrary clinical reasoning. Aim of this work was to assess the feasibility of a decision support system for the assisted diagnosis of brain cancer, such approach presenting potential for early diagnosis of tumors and for the classification of the degree of the disease progression. For this purpose, a supervised learning algorithm combined with a pattern recognition method was developed and cross-validated in ¹⁸F-FDG PET studies of a model of a brain tumour implantation.

Published
2013

44. Statistical Parametric Mapping for activation studies in rats

Author

Gallivanone, F, Grosso, E, Di Grigoli, G, Valtorta, Silvia, MORESCO, ROSA MARIA, SALVATORE, CHRISTIAN, GILARDI, MARIA CARLA, CASTIGLIONI, ISABELLA, Gallivanone, F, Grosso, E, Di Grigoli, G, Salvatore, C, Valtorta, S, Gilardi, M, Moresco, R, and Castiglioni, I

Subjects
SPM
Published
2012

45. SPM for activation studies in rats on stress condition

Author

Gallivanone, F, Di Grigoli, G, Valtorta, Silvia, Grosso, E, MORESCO, ROSA MARIA, SALVATORE, CHRISTIAN, GILARDI, MARIA CARLA, CASTIGLIONI, ISABELLA, Gallivanone, F, Di Grigoli, G, Salvatore, C, Valtorta, S, Grosso, E, Gilardi, M, Moresco, R, and Castiglioni, I

Subjects
SPM
Published
2012

46. 18FDG PET/CT Image-Guided Simultaneous Integrated Boost Intensity-Modulated Radiotherapy in Head and Neck cancer

Author

Mapelli P, Grosso E, Dell'Oca I, Kirienko M, CASTIGLIONI I, Villa E, Gianolli L, Picchio M, Messa C, Mapelli, P, Grosso, E, Dell’Oca, I, Kirienko, M, Castiglioni, I, Villa, E, Gianolli, L, Picchio, M, Messa, C., Dell'Oca, I, and Messa, C

Subjects
pet ct
Abstract

AIM: To evaluate early outcome of simultaneous integrated boost (SIB) on PET positive sub-volume (Biological Target Volume BTV) intensity-modulated radiotherapy (BTV-SIB-IMRT) in Head and Neck cancer (HNC) patients. MATERIALS and METHODS: Forty-eight HNC patients (36 men, 12 women, mean age 58 yrs, range 23-81; 35.4% I-II-III pTNM stages (I (4.2%), II (12.5%), and III (18.7%)) and 64.6% IV pTNM stage disease; local extension T1-T2 in 58.3% and T3-T4 in 41.7%; tumor site oropharynx in 43.7% and rinopharynx 39.6% , 16.7% other; 56.2% squamocellular and 37.5% undifferentiated carcinoma, 6.2% other) treated by BTV-SIB-IMRT between 2005 and 2011 at dose of 69 Gy, 30 fractions, were retrospectively included in the study. Two-year disease-free (DFS), local relapse-free (LRFS) and distant metastases-free survival (DMFS) were calculated and correlated to tumor stage, local extension, site and histology. RESULTS: On stage based analysis (I-II vs III-IV) DFS, LRFS and DMFS were 88, 88 and 100% vs 55, 63 and 76%; while comparing I-II-III vs IV the figures were 88, 88 and 94% vs 45 (p

Published
2012

47. 2D recurrent neural networks for robust visual tracking of non-rigid bodies

Author

Masala, GL, Golosio, B, Tistarelli, M, Grosso, E, Masala, GL, Golosio, B, Tistarelli, M, and Grosso, E

Abstract

© Springer International Publishing Switzerland 2016. The efficient tracking of articulated bodies over time is an essential element of pattern recognition and dynamic scenes analysis. This paper proposes a novel method for robust visual tracking, based on the combination of image-based prediction and weighted correlation. Starting from an initial guess, neural computation is applied to predict the position of the target in each video frame. Normalized cross-correlation is then applied to refine the predicted target position. Image-based prediction relies on a novel architecture, derived from the Elman’s Recurrent Neural Networks and adopting nearest neighborhood connections between the input and context layers in order to store the temporal information content of the video. The proposed architecture, named 2D Recurrent Neural Network, ensures both a limited complexity and a very fast learning stage. At the same time, it guarantees fast execution times and excellent accuracy for the considered tracking task. The effectiveness of the proposed approach is demonstrated on a very challenging set of dynamic image sequences, extracted from the final of triple jump at the London 2012 Summer Olympics. The system shows remarkable performance in all considered cases, characterized by changing background and a large variety of articulated motions.

Published
2016

48. Accessing Cloud Services through Biometrics Authentication

Author

Ruiu, P, Caragnano, G, Masala, GL, Grosso, E, Ruiu, P, Caragnano, G, Masala, GL, and Grosso, E

Abstract

© 2016 IEEE. The adoption of Cloud computing involves many advantages in terms of flexibility, scalability and reliability, but also implies new challenges on security, data privacy and protection of personal data. Since more and more sensitive applications and data are moved to the cloud, the verification of the digital identity of the participants in the electronic communication has become a crucial challenge. Currently, the use of biometric techniques can be considered as an effective solution to ensure a significant increase of security in the authentication protocols managed by modern authentication servers. However the use of biometric data for the logical access to IT services is a more challenging and still unsolved problem. The project Cloud for SME integrates a biometric authentication based on fingerprints with a cloud computing platform, investigating how highly secure authentication methods can increase the adoption of cloud computing technologies among small and medium enterprises.

Published
2016

49. A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutations

Author

Brussino A., Vaula G., Cagnoli C., Di Gregorio E., Scappaticci S., Camanini S., Daniele D., Bradac G. B., Pinessi L., Cavalieri S., Grosso E., Migone N., Brusco A., PANZA, EMANUELE, SERI, MARCO, Brussino A., Vaula G., Cagnoli C., Panza E., Seri M., Di Gregorio E., Scappaticci S., Camanini S., Daniele D., Bradac G.B., Pinessi L., Cavalieri S., Grosso E., Migone N., and Brusco A.

Subjects
Adult, Male, DNA Copy Number Variations, Genetic Linkage, Leukoencephalopathies, Gene Duplication, demyelinating diseases, genetic linkage study, leukodystrophies, LMNB1, MRI, neurodegenerative disorders, Humans, Point Mutation, Family, Age of Onset, Aged, Sequence Deletion, Lamin Type B, Middle Aged, Leukodystrophy, Globoid Cell, Hereditary Central Nervous System Demyelinating Diseases, Phenotype, Italy, Mutation, Chromosomes, Human, Pair 5, Female, Microsatellite Repeats
Abstract

Background and purpose: Duplications of lamin B1 (LMNB1) at 5q23 are implicated in adult-onset autosomal dominant leukodystrophy (ADLD) having been described in six families with diverse ethnic background but with a homogeneous phenotype. In a large Italian family, we recently identified a variant form of ADLD characterized clinically by absence of the autonomic dysfunction at onset described in ADLD and, on MRI, by milder cerebellar involvement with sparing of hemispheric white matter. Aim of this study was to investigate the genetic basis of this variant form of ADLD. Methods: We carried out a genome-wide linkage analysis using microsatellite markers, and the genes in the candidate region were screened for point mutations. LMNB1 was also screened for deletions/duplications by real-time PCR, multiplex ligation-dependent probe amplification and Southern blot. Results: We mapped the variant ADLD locus to 5q23.2-q23.3, a genomic region containing 11 genes including LMNB1. Neither gene copy-number defects nor point mutations in the LMNB1 gene were found. We also excluded point mutations in the coding exons of the other ten genes in the candidate region. However, expression of lamin B1 evaluated in lymphoblastoid cells was higher in patients than in healthy controls, and was similar to the lamin B1 expression levels found in a patient with LMNB1 duplication. Conclusions: This observation suggests that a mutation in an LMNB1 regulatory sequence underlies the variant ADLD phenotype. Thus, adult forms of ADLD linked to 5q23 appear to be more heterogeneous clinically and genetically than previously thought.

Published
2010

50. GERMLINE PROKINETICIN RECEPTOR 2 (PROKR2) VARIANTS ASSOCIATED WITH CENTRAL HYPOGONADISM CAUSE DIFFERENTAL MODULATION OF DISTINCT INTRACELLULAR PATHWAYS

Author

Domenico Vladimiro Libri, Gunnar, Kleinau, Valeria, Vezzoli, Marta, Busnelli, Fabiana, Guizzardi, Antonio Agostino Sinisi, Angela Ida Pincelli, Antonio, Mancini, Gianni, Russo, Paolo Beck Peccoz, Sandro, Loche, Claudio, Crivellaro, Maghnie, Mohamad, Csilla, Krausz, Luca, Persani, Marco, Bonomi, Aimaretti, G., Altobelli, M., Arnaldi, G., Baldi, M., Bartalena, L., Beccaria, L., Bellastella, G., Bellizzi, M., Bona, G., Borretta, G., Buzi, F., Cannavo, S., Cappa, M., Cariboni, A., Ciampani, T., Cicognani, A., Cisternino, M., Corbetta, S., Corciulo, N., Corona, G., Cozzi, R., D'Elia, A. V., Degli Uberti, E., De Marchi, M., Forti, G., Di Iorgi, N., Isidori, Andrea, Fabbri, A., Ferlin, A., Foresta, C., Franceschi, R., Garolla, A., Gaudino, R., Giagulli, V., Grosso, E., Jannini, E., Lanfranco, F., Larizza, L., Lenzi, A., Lombardo, Francesco, Limone, P., Maggi, M., Maggi, R., Maggio, M. C., Mandrile, G., Marino, M., Mencarelli, M. A., Migone, N., Neri, G., Perroni, L., Pignatti, E., Pilotta, A., Pizzocaro, A., Pontecorvi, A., Pozzobon, G., Prodam, F., Radetti, G., Razzore, P., Salerno, M. C., Salvatoni, A., Salvini, F., Secco, A., Segni, Maria, Simoni, M., Vigneri, R., Weber, G., Libri, Dv, Kleinau, G, Vezzoli, V, Busnelli, M, Guizzardi, F, Sinisi, Antonio Agostino, Pincelli, Ai, Mancini, A, Russo, G, Beck Peccoz, P, Loche, S, Crivellaro, C, Maghnie, M, Krausz, C, Persani, L, Bonomi, M., Libri DV, Kleinau G, Vezzoli V, Busnelli M, Guizzardi F, Sinisi AA, Pincelli AI, Mancini A, Russo G, Beck-Peccoz P, Loche S, Crivellaro C, Maghnie M, Krausz C, Persani L, Bonomi M, Maggio MC, et al, Libri, Domenico Vladimiro, Kleinau, Gunnar, Vezzoli, Valeria, Busnelli, Marta, Guizzardi, Fabiana, Pincelli, Angela Ida, Mancini, Antonio, Russo, Gianni, Beck Peccoz, Paolo, Loche, Sandro, Crivellaro, Claudio, Maghnie, Mohamad, Krausz, Csilla, Persani, Luca, Bonomi, Marco, and Salerno, Mariacarolina

Subjects
Male, Kallmann syndrome, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Inositol Phosphate, medicine.disease_cause, Biochemistry, Hypogonadotropic hypogonadism, Germline, Receptors, G-Protein-Coupled, Cohort Studies, Endocrinology, Settore MED/38 - Pediatria Generale E Specialistica, Adolescent, Adult, Child, Cyclic AMP, Female, Genetic Association Studies, Humans, Hypogonadism, Inositol Phosphates, Middle Aged, Mutation, Missense, Receptors, Peptide, Signal Transduction, Young Adult, Germ-Line Mutation, Receptors, mutations, septo-optic dysplasia, Missense mutation, Receptor, Mutation, Prokineticin, Peptide, Human, medicine.medical_specialty, Adolescent, Adult, Child, Cohort Studies, Cyclic AMP, metabolism, Female, Genetic Association Studies, Germ-Line Mutation, Humans, Hypogonadism, epidemiology/genetics, Inositol Phosphates, metabolism, Male, Middle Aged, Missense, Receptors, G-Protein-Coupled, genetics, Receptors, genetics, Signal Transduction, genetics, Young Adult, Genetic Association Studie, Biology, Germline mutation, Internal medicine, medicine, Biochemistry (medical), Prokineticin receptor 2, medicine.disease, PROKR2, hypogonadism, prokineticin, Missense, Cohort Studie
Abstract

INTRODUCTION: Defects of prokineticin pathway affect the neuroendocrine control of reproduction, but their role in the pathogenesis of central hypogonadism remains undefined, and the functional impact of the missense PROKR2 variants has been incompletely characterized. MATERIAL AND METHODS: In a series of 246 idiopathic central hypogonadism patients, we found three novel (p.V158I, p.V334M, and p.N15TfsX30) and six already known (p.L173R, p.T260M, p.R268C, p.V274D, p.V331M, and p.H20MfsX23) germline variants in the PROKR2 gene. We evaluated the effects of seven missense alterations on two different prokineticin receptor 2 (PROKR2)-dependent pathways: inositol phosphate-Ca(2+) (Gq coupling) and cAMP (Gs coupling). RESULTS: PROKR2 variants were found in 16 patients (6.5%). Expression levels of variants p.V158I and p.V331M were moderately reduced, whereas they were markedly impaired in the remaining cases, except p.V334M, which was significantly overexpressed. The variants p.T260M, p.R268C, and p.V331M showed no remarkable changes in cAMP response (EC50) whereas the IP signaling appeared more profoundly affected. In contrast, cAMP accumulation cannot be stimulated through the p.L173R and p.V274D, but IP EC50 was similar to wt inp.L173R and increased by 10-fold in p.V274D. The variant p.V334M led to a 3-fold increase of EC50 for both cAMP and IP. CONCLUSION: Our study shows that single PROKR2 missense allelic variants can either affect both signaling pathways differently or selectively. Thus, the integrity of both PROKR2-dependent cAMP and IP signals should be evaluated for a complete functional testing of novel identified allelic variants.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results