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3. First-in-Human Multicenter Experience of the Newest Generation Supra-Annular Self-Expanding Evolut FX TAVR System

Author

Zaid, Syed, Attizzani, Guilherme F., Krishnamoorthy, Parasuram, Yoon, Sung-Han, Palma Dallan, Luis A., Chetcuti, Stanley, Fukuhara, Shinichi, Grossman, P. Michael, Goel, Sachin S., Atkins, Marvin D., Kleiman, Neal S., Puri, Rishi, Bakhtadze, Beka, Byrne, Timothy, Ibrahim, Akram W., Grubb, Kendra J., Tully, Andy, Herrmann, Howard C., Faggioni, Michela, Ramlawi, Basel, Khera, Sahil, Lerakis, Stamatios, Dangas, George D., Kini, Annapoorna S., Sharma, Samin K., Reardon, Michael J., and Tang, Gilbert H.L.

Published
2023
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9. 1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses

Author

Deeb, G. Michael, Chetcuti, Stanley J., Reardon, Michael J., Patel, Himanshu J., Grossman, P. Michael, Schreiber, Theodore, Forrest, John K., Bajwa, Tanvir K., O’Hair, Daniel P., Petrossian, George, Robinson, Newell, Katz, Stanley, Hartman, Alan, Dauerman, Harold L., Schmoker, Joseph, Khabbaz, Kamal, Watson, Daniel R., Yakubov, Steven J., Oh, Jae K., Li, Shuzhen, Kleiman, Neal S., Adams, David H., and Popma, Jeffrey J.

Published
2017
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13. Multifaceted Intervention to Improve P2Y12 Inhibitor Adherence After Percutaneous Coronary Intervention: A Stepped Wedge Trial

Author

Ho, P. Michael, primary, O’Donnell, Colin I., additional, McCreight, Marina, additional, Bavry, Anthony A., additional, Bosworth, Hayden B., additional, Girotra, Saket, additional, Grossman, P. Michael, additional, Helfrich, Christian, additional, Latif, Faisal, additional, Lu, David, additional, Matheny, Michael, additional, Mavromatis, Kreton, additional, Ortiz, Jose, additional, Parashar, Amitabh, additional, Ratliff, Devona M., additional, Grunwald, Gary K., additional, Gillette, Michael, additional, and Jneid, Hani, additional

Published
2022
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15. Outcomes in patients with electrocardiographic left ventricular dyssynchrony following transcatheter aortic valve replacement.

Author

Ananwattanasuk, Teetouch, Atreya, Auras R., Teerawongsakul, Padoemwut, Ghannam, Michael, Lathkar-Pradhan, Sangeeta, Latchamsetty, Rakesh, Jame, Sina, Patel, Himanshu J., Grossman, Paul Michael, Oral, Hakan, and Jongnarangsin, Krit

Abstract

Left bundle branch block (LBBB) and atrioventricular (AV) conduction abnormalities requiring permanent pacemaker (PPM) implantation occur frequently following transcatheter aortic valve replacement (TAVR). The resultant left ventricular (LV) dyssynchrony may be associated with adverse clinical events. The purpose of this study was to assess the adverse outcomes associated with LV dyssynchrony due to high-burden right ventricular (RV) pacing or permanent LBBB following TAVR in patients with preserved left ventricular ejection fraction (LVEF). Consecutive TAVR patients at the University of Michigan from January 2012 to June 2017 were included. Pre-existing cardiac implantable electronic device, previous LBBB, LVEF <50%, or follow-up period <1 year were excluded. The primary outcome was all-cause mortality. Secondary outcomes included cardiomyopathy (defined as LVEF ≤45%), a composite endpoint of cardiomyopathy or all-cause mortality, and the change in LVEF at 1-year follow-up. A total of 362 patients were analyzed (mean age 77 years). LV dyssynchrony group (n = 91 [25.1%]) included 56 permanent LBBB patients, 12 permanent LBBB patients with PPM, and 23 non-LBBB patients with PPM and high-burden RV pacing. Remaining patients served as control (n = 271 [74.9%]). After adjusted analysis, LV dyssynchrony had significantly higher all-cause mortality (adjusted hazard ratio [HR] 2.16; 95% confidence interval [CI] 1.07–4.37) and cardiomyopathy (adjusted HR 14.80; 95% CI 6.31–14.69). The LV dyssynchrony group had mean LVEF decline of 10.5% ± 10.2% compared to a small increase (0.5% ± 7.7%) in control. Among TAVR patients with preserved LVEF and normal AV conduction, development of postprocedural LV dyssynchrony secondary to high-burden RV pacing or permanent LBBB was associated with significantly higher risk of death and cardiomyopathy at 1-year follow-up. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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17. Aortic valve reintervention in patients with failing transcatheter aortic bioprostheses: A statewide experience

Author

Fukuhara, Shinichi, primary, Tanaka, Daizo, additional, Brescia, Alex A., additional, Wai Sang, Stephane Leung, additional, Grossman, P. Michael, additional, Sukul, Devraj, additional, Chetcuti, Stanley J., additional, He, Chang, additional, Eng, Marvin H., additional, Patel, Himanshu J., additional, and Deeb, G. Michael, additional

Published
2021
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22. Cardiac-specific norepinephrine mass transport and its relationship to left ventricular size and systolic performance

Author

Grossman, P. Michael, Linares, Oscar A., Supiano, Mark A., Oral, Hakan, Mehta, Rajendra H., and Starling Mark R.

Subjects
Noradrenaline -- Research, Biological sciences
Abstract

Objectives of this study were to develop a technique for quantifying cardiac-specific norepinephrine (NE) mass transport and determine whether cardiac NE kinetic modeling parameters were related to physiological variables of left ventricular (LV) size and systolic performance in nine patients with chronic mitral regurgitation. Biplane contrast cineventriculograms were used to determine LV size and ejection fraction (EF), micromanometer LV pressures and radionuclide LV volumes from a range of loading conditions to calculate LV end-systolic elastance, and [[sup.3]H]NE infusions with LV and coronary sinus sampling for [[sup.3]H]NE and endogenous NE during and after termination of infusions to model NE mass transport. Total NE release rate into cardiac interstitial fluid ([M.sup.R.sub.IF]) averaged 859 [+ or -] 214 and NE released de novo into cardiac interstitial fluid ([M.sup.u,r,en.sub.IF]) averaged 546 [+ or -] 174 pmol/min. Both ([M.sup.R.sub.IF]) and ([M.sup.u,r,en.sub.IF]) correlated directly with LV end-systolic volume (r = 0.84, P = 0.005; r = 0.86, P = 0.003); inversely with LV EFs (r = -0.75, P = 0.02; r = -0.81, P = 0.008); and inversely with LV end-systolic elastance values, optimally fit by a nonlinear function (r = 0.89, P = 0.04; r = 0.96, P = 0.01). We conclude that total and newly released NE into interstitial fluid of the heart, determined by regional mass transport kinetic model, are specific measures of regional cardiac-specific sympathetic nervous system activity and are strongly related to measures of LV size and systolic performance. These data support the concept that this new model of organ-specific NE kinetics has physiological relevance. mitral regurgitation; left ventricle; ejection fraction; contractility

Published
2004

23. The Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography

Author

Soomro, Qandeel H., Anand, Sonia T., Weisbord, Steven D., Gallagher, Martin P., Ferguson, Ryan E., Palevsky, Paul M., Bhatt, Deepak L., Parikh, Chirag R., Kaufman, James S., Brophy, Mary, Chertow, Glenn, Conner, Todd, Ferguson, Ryan, Fine, M., Kaufman, James, Lew, Robert, McCullough, Peter, Palevsky, Paul, Parikh, Chirag, Ringer, Robert, Shunk, Kendrick, Soliva, Susan, Weisbord, Steven, Bhatt, Deepak, Cass, Alan, Gallagher, Martin, McFalls, Edward, Pirakh, Chirag, Wu, Hongsheng, Ratliff, Michelle, Ketteler, Erika, Goff, James, Snider, Richard, Jones, Debra, Kreuch, Jeannie, Duvernoy, Claire, Thomas, Michael, Willatt, Jonathan, Gurm, Hitinder, Krishnamurthy, Venkat, Nallamothu, Brahmajee, Szymanski, Kendra, Grossman, P. Michael, Menees, Daniel, Rose, Patricia, Mavromatis, Kreton, Kumar, Gautam, Raghavan, Sumati, Dow, Jeanne, Mandawat, Mahendra, Noe, Susan, Alavi, Hossain, Calkins, Joe, McNear, Jennifer, Beals, Donald, Cavalieri, Stuart, Sierzega, Renata, Pearson, Laura, Afaq, Mazhar, Vaitkus, Paul, Kudryk, Bruce, Hall, Dennis, Nadella, Neelima, Corin, William, Woklu, Nina, Inting-Toothman, Stella, Wescott, Lea, Ventura, Nicole, Kinlay, Scott, Croce, Kevin, Faxon, David, Vokonas, Pantel, Raffetto, Joseph, McPhee, James, Gupta, Naren, Nava, Adrianna, Ly, Samantha, My-Do, Jacquelyn, Ostrowski, Simon, Bundy, Mariah, Quinn, Margot, Chin, Melissa, Corbelli, John, Dosluoglu, Hasan, Lohr, James, Rivero, Mariel, Cooke, Beth, Galla, Ann, Cloen, Denise, Fernandes, Valerian, DiBona, Alexander, Nielsen, Christopher, Idleman, Lois, Lee, Bertha, Vidovich, Mladen, Kibbe, Melina, Griza, Decebal, Raicu, Mihai, Rothenberg, Florence, Thakar, Charuhas, Madabhushi, Aditi, Arif, Imran, Bath, Jonathan, Helmy, Tarek, Unterbrink, Kendra, Ross, Stephanie, Bailey, Cathy, Hailes, Myrtle, Goldberg, Jonathan, Jozic, Joseph, Kang, Preet, Kalman, Jeaniene, Rosenthal, Noah, Catania, Deborah, Marlow, Jeanne, Kumaran, Vinay, Krupka, Angela, Zappernick, Taissa, Brilakis, Emmanouil, Tsai, Shirling, Banerjee, Subhash, Modrall, J. Gregory, Roesle, Michele, Hamilton, Marcie, Lusk, Cassie, Compton, Jennifer, Willis, Cyenthia, Atwell, Amy, Soto-Gonzalez, Marilisa, Agarwal, Ajay, Saklayen, Mohammad, Woerner, Donna, Ross, Jeffrey, Turner, Karen, Zheng-Phelan, Ling, Rider, Kamia, Rao, Sunil, Jones, W. Schuyler, Povsic, Thomas, Krucoff, Mitchell, Brennan, James, Miller, Michael, Mureebe, Leila, Aristy, Kathy, Powell, Marilyn, Bavry, Anthony, Choi, Calvin, Park, Ki, Curry, Tempa, Robertson, Debra, Wright, Cila, Jneid, Hani, Paniagua, David, Denktas, Ali, Lara-Smalling, Agueda, Palmer, Leah, Malarchick, Jo Ann, Broussard, Emily, Bolad, Islam, Breall, Jeffrey, Motaganahalli, Raghunandan, English, Beth, Ramkaransingh, Jeffrey, Mukerji, Rita, Subbarao, Roopa, Williams, Vicki, Henson, Sharon, Krier, Connie, Parashara, Deepak, Ciniglio, Ricardo, Barua, Rajat, Roys, Michael, Surineni, Kamalakar, Mendes, Kimberley, Oni, Olurinde, Uretsky, Barry, Ahmed, Zubair, Yousaf, Muhammad, Hakeem, Abdul, Chung, Hui Yong, Miller, Kristin, Dishongh, Katherine, Ramanathan, Kodangudi, Shah, Rahman, McGee, Jesse, Qualls, Zoe, Armstrong, Ashley, Johnson, Lillie, Garcia, Santiago, Adabag, Selcuk, Vakil, Kairav, Nguyen, Jennifer, Berg, Matthew, Herrmann, Rebekah, Condon, Debra, Meyeraan, Tacy, Sedlis, Steven, Lorin, Jeffrey, Keary, Mary, Shah, Binita, Maranan, Leandro, Latif, Faisal, Thadani, Udho, Abu-Fadel, Mazen, Exaire, Jose, Rousan, Talla, Ramirez-Jimenez, Arleen, Pham, Trang, Giacomini, John, Lit, Yiming, Massaband, Payam, Yong, Celina, Fearon, William, Zhou, Wei, Aalami, Oliver, Peters, Theresa, Bratcher, Karen, Monteverde, Edgardo, Rahman, Aref, Bandi, Rupal, Garbelotti, Kelly, Mulukutla, Suresh, Overberger, Pamela, Watnick, Suzanne, Davies, Crispin, Larsen, Greg, Atkinson, Tamara, Walczyk, Jacqueline, Kenworthy-Heinige, Tawni, Guenther, Stephanie, Pitts, Alexandra, Jovin, Ion, Minisi, Anthony, Sumption, Kevin, Feldman, George, Ha, Jonathan, Hendrix, Mack, Maldonado, Maureen, Jeter, Deborah, Klein, Andrew, Forsberg, Michael, Rowe, Caroline, Nasir, Ammar, Mani, Kartik, Vercher, Paul, Waidmann, Kristi, Vargo, Kristin, Chilakapati, Venkata, Jarmukli, Nabil, Tan, Shen-Li, Sherigar, Rathnakara, Bottomley, Sharon, Capuno, Maribeth, Henley, Katherine, Dev, Devasmita, Mathew, Jacob, Ochalek, Tracy, Lui, Charles, Smith, Brigham, Huo, Eugene, Frodsham, Aaron, Eskelson, Noni, Velarde, Kandi, Dulin, Heather, Martinez, Lillian, Zimmet, Jeffrey, Sawhney, Rajiv, Malik, Fady, Chou, Tony, Huynh, Cynthia, Stanley, Kathleen, Garcia, Epifanio, Lehmann, Kenneth, Stadius, Michael, Beatty, Alexis, Naria, Sohilkumar, Galvin, Georgia, Chilton, Robert, Pham, Son, Oliveros, Rene, Hecht, Joan, Thai, Hoang, Truong, Huu Tam, Goldman, Steven, Thal, Sergio, Juneman, Elizabeth, Kapoor, Divya, Tsuda, Ryan, Kipps, Juliana, Mikhail, Amani, Sandoval, Michael, Currier, Jesse, Lee, Hsin-Yi, Chang, Donald, Walsworth, Matthew, Warner, Alberta, Chen, Alice, Lendvai, Dora, Johnson, Janet, Lee, Joanne, Coggan, Sarah, Kumar, Namrata Nath, Dempsey, Erika, Kotwal, Sradha, Smyth, Brendan, Yianni, Alexia, Lee, Li Hui, Cheong, Siew Yan, Yates, Casey, James, Earl, Talaulikar, Girish, Farshid, Ahmad, Johnson, Patricia, Taverner, Pearle, Chadwick, Heather, Stewart, Ralph, Benatar, Jocelyne, Stone, Louise, Howell, Leah, Anderson, Sue, Lehnhard, Siobhan, Patten, Cathrine, Farouque, Omar, Bellomo, Rinaldo, Horrigan, Mark, Scott, Peter, Jones, Nicolas, Yudi, Matias, Huq, Rafi, Al-Fiadh, Ali, Brown, Louise, Brieger, David, Hillis, Graham, Cherry, Jonathan, Aitken, Sarah, Anastasius, Malcom, Lau, Jerrett, Lowe, Harry, Ayoub, Chadi, Jardine, Meg, O?Connor, Jody, Wong, Christopher, Wu, June, Xu, Kitty, Webster, Julie, Mwaijele, Liliang, Hand, Samantha, Chew, Derek, Alyward, Philip, Balakrishnan, Deepu, Prakash, Roshan, Pathik, Bhupesh, Kinatra, Vineet, Jones, Dylan, Singh, Arun, Ratib, Karim, Hammad, Nassser Al, Gunton, James, Mazhar, Jawad, Musameh, Muntaser, O?Shea, Catherine, Judd, Jo, Raman, Betty, Wollaston, Fiona, Felice, Kerri Ann, Hincks, Christine, Harrison, Timothy, Fawcett, Malcolm, Wright, Therese, Horsfall, Lee-Anne, Kissajukian, Francis, Murphy, Diedre, Bartlett, Pamela, Stockle, Paul, William, Maged, Elsokkari, Ihab, Rangasamy, Karthikeyan, Roy, Probal, Tran, David, Hayat, Muhammed Umair, May, Austin, Nyakudarika, Elijah, Phang, Calvin, Conway, Bets, O?Donoghue, Michelle, Ellis, Katrina, Kanna, Rajesh, Hendriks, Randall, Forrest, Nicole, Tulloch, Gill, Greenwell, Della, Ghapar, Abd Kahar, Ghani, Abdul Raqib Abd, Sundaralingam, Shamini, Fuah, K., Habizal, Nor Halwani, Daud, Siti Rohaya, Haq, Hafsah Begum binti Abdul, Mohammad, Masliza Binti, Hassan, Faizah Che, Hashim, Hanani, Ismail, Omar, Kong, Poi Keong, Ma, Soot Keng, Wahab, Mohamed Jahangir Abdul, Abdulla, Zarina Banu, Kader, Mohamad Ali Sheikh Abdul, Goh, Chong Aik, Ahmadsha, Shahul Hamid, Naser, Mohamad Nazrulhisham Mad, Yusuf, Azizah, Govindasamy, Paramesveri, Ibrahim, Nur Azliati Binti, Yahaya, Normilah, Juergens, Craig, French, John, Mussap, C., Lo, Sidney, Burgess, S., Mallard, Trevor, Huang, Justin, Kumar, Manish, Lee, Adam, Leung, Dominic, Badie, Tamar, Xu, James, Terluk, Andrew, Croucher, Alexandria, O?Brien, Kelsey, Raynes, Suzanne, Plotz, Maria, Hallani, Hisham, Fernandes, Clyne, Fitzpatrick, Drew, Parikh, Devang, Coulshed, David, Pathan, Faraz, Ganda, Prashil, Chandrala, Pavan, Barry, Lisa, Mackenzie, Michele, VanGaal, William, Hyat, Umair, Tsay, It Men, Subiakto, Ivan, Cresp, Damian, Nelson, Gregory, Mau, James, Shaw, Elizabeth, Yan, Warren, Arena, Frank, Danson, Edward, Vernon, S., Ward, Michael, Allahwala, U., Reid, Emma, Straiton, Nicola, Whitley, Alexandra, Loxton, Annie, Erickson, Royal Perth Hospital: Matthew, Ihdayid, Abdul-Rhman, Dias, Peter, Atique, Syed, Bonner, Michelle, Venn-Edmonds, Clare, Prasan, Ananth, Sader, Mark, Ramsay, David, Ford, Tom, Weaver, James, Binnekamp, Maurits, Barrett, David, Roy, James, Ng, Ben, Youssef, George, Shrestha, Prakriti, Vrachas, Deborah, Dobinson, Kate, Ternouth, Ian, Lumb, Nicky, Sebastian, Jeffrey, Jackson, Carolyn, Vickers, Cathy, Prideaux, Jan, Ahmad, Wan Azman Wan, Abidin, Imran Zainal, Zuhdi, Ahmad Syadi Mahmood, Ismail, Muhammad Dzafir, Sridhar, Ganiga Srinivasaiah, Lim, Soo Kun, Hadi, Moud Firdaus, Adnan, Wan Ahmad Hafiz Wan Md, Kassim, Zainab Abu, Mansor, Syed Mukhtar Syed, Lee, Vin-Zhen, Harding, Scott, Ranchord, Anil, Matsis, Philip, Aitken, Andrew, Simmonds, Mark Bernard, Fairley, Sarah, Wolbinski, Mariusz, Plunkett, Susan, Sinan, Ali Al, Ferrier, Katherine, O?Meeghan, Tim, Wilkins, Ben, Anscomise, Russell, Sasse, Alexander, Kirby, Alyssa, Ershad, Shakiya, Smyth, Duncan, Lim, Ren Yik, Middleditch, Diane, and Davies, Bronwyn

Published
2022
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26. Early Structural Valve Degeneration of Trifecta Bioprosthesis

Author

Fukuhara, Shinichi, primary, Shiomi, Suzuna, additional, Yang, Bo, additional, Kim, Karen, additional, Bolling, Steven F., additional, Haft, Jonathan, additional, Tang, Paul, additional, Pagani, Francis, additional, Prager, Richard L., additional, Chetcuti, Stanley, additional, Grossman, P. Michael, additional, Patel, Himanshu J., additional, and Deeb, G. Michael, additional

Published
2020
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28. Transcatheter Aortic Valve Replacement with a Self-Expanding Prosthesis.

Author

Hughes, Erinn and Grossman, Paul Michael

Abstract

The self-expanding transcatheter heart valve (Medtronic Cardiovascular Corevalve and Evolut) is a supra-annular, trileafet porcine pericardial valves on a diamond lattice nickel-titanium alloy frame. The TAVR device has undergone significant improvements in design and procedural techniques to further increase safety, efficacy, and durability since they it was first released. Unique design characteristics, as well as patient and procedural factors, favor self-expanding over balloon-expandable prostheses in certain situations. The self-expanding transcatheter heart valve has proven to be an excellent option for severe aortic stenosis patients with any level of surgical risk and preliminary data suggest a comparable durability to surgical tissue valves. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Expanding opportunities to understand quality and outcomes of peripheral vascular interventions: The ACC NCDR PVI Registry

Author

Jones, W. Schuyler, primary, Kennedy, Kevin F., additional, Hawkins, Beau M., additional, Attaran, Robert R., additional, Secemsky, Eric A., additional, Latif, Faisal, additional, Shammas, Nicolas W., additional, Feldman, Dmitriy N., additional, Aronow, Herbert D., additional, Gray, Bruce, additional, Armstrong, Ehrin J., additional, Grossman, P. Michael, additional, Ho, Kalon K.L., additional, Prasad, Anand, additional, Jaff, Michael R., additional, Rosenfield, Kenneth, additional, and Tsai, Thomas T., additional

Published
2019
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31. Self-Expanding Transcatheter Aortic Valve Replacement in Patients With Low-Gradient Aortic Stenosis

Author

Chetcuti, Stanley J., primary, Deeb, G. Michael, additional, Popma, Jeffrey J., additional, Yakubov, Steven J., additional, Grossman, P. Michael, additional, Patel, Himanshu J., additional, Casale, Alfred, additional, Dauerman, Harold L., additional, Resar, Jon R., additional, Boulware, Michael J., additional, Dries-Devlin, Jessica L., additional, Li, Shuzhen, additional, Oh, Jae K., additional, and Reardon, Michael J., additional

Published
2019
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32. Safety and efficacy of thrombectomy in patients undergoing primary percutaneous coronary intervention for Acute ST elevation MI: A Meta-Analysis of Randomized Controlled Trials

Author

Grossman P Michael, Hameed Irfan, Chetcuti Stanley, Tamhane Umesh U, Moscucci Mauro, and Gurm Hitinder S

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Clinical trials comparing thrombectomy devices with conventional percutaneous coronary interventions (PCI) in patients with acute ST elevation myocardial infarction (STEMI) have produced conflicting results. The objective of our study was to systematically evaluate currently available data comparing thrombectomy followed by PCI with conventional PCI alone in patients with acute STEMI. Methods Seventeen randomized trials (n = 3,909 patients) of thrombectomy versus PCI were included in this meta-analysis. We calculated the summary odds ratios for mortality, stroke, post procedural myocardial blush grade (MBG), thrombolysis in myocardial infarction (TIMI) grade flow, and post procedural ST segment resolution (STR) using random-effects and fixed-effects models. Results There was no difference in risk of 30-day mortality (44/1914 vs. 50/1907, OR 0.84, 95% CI 0.54-1.29, P = 0.42) among patients randomized to thrombectomy, compared with conventional PCI. Thrombectomy was associated with a significantly greater likelihood of TIMI 3 flow (1616/1826 vs. 1533/1806, OR 1.41, P = 0.007), MBG 3 (730/1526 vs. 486/1513, OR 2.42, P < 0.001), STR (923/1500 vs. 715/1494, OR 2.30, P < 0.001), and with a higher risk of stroke (14/1403 vs. 3/1413, OR 2.88, 95% CI 1.06-7.85, P = 0.04). Outcomes differed significantly between different device classes with a trend towards lower mortality with manual aspiration thrombectomy (MAT) (21/949 vs.36/953, OR 0.59, 95% CI 0.35-1.01, P = 0.05), whereas mechanical devices showed a trend towards higher mortality (20/416 vs.10/418, OR 2.07, 95% CI 0.95-4.48, P = 0.07). Conclusions Thrombectomy devices appear to improve markers of myocardial perfusion in patients undergoing primary PCI, with no difference in overall 30-day mortality but an increased likelihood of stroke. The clinical benefits of thrombectomy appear to be influenced by the device type with a trend towards survival benefit with MAT and worsening outcome with mechanical devices.

Published
2010
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34. Impact of Annular Size on Outcomes After Surgical or Transcatheter Aortic Valve Replacement

Author

Deeb, G. Michael, primary, Chetcuti, Stanley J., additional, Yakubov, Steven J., additional, Patel, Himanshu J., additional, Grossman, P. Michael, additional, Kleiman, Neal S., additional, Heiser, John, additional, Merhi, William, additional, Zorn, George L., additional, Tadros, Peter N., additional, Petrossian, George, additional, Robinson, Newell, additional, Mumtaz, Mubashir, additional, Gleason, Thomas G., additional, Huang, Jian, additional, Conte, John V., additional, Popma, Jeffrey J., additional, and Reardon, Michael J., additional

Published
2018
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35. Contrast‐induced nephropathy in patients undergoing endovascular peripheral vascular intervention: Incidence, risk factors, and outcomes as observed in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium

Author

Grossman, P. Michael, primary, Ali, Syed S., additional, Aronow, Herbert D., additional, Boros, Michael, additional, Nypaver, Timothy J., additional, Schreiber, Theodore L., additional, Park, Yeo Jung, additional, Henke, Peter K., additional, and Gurm, Hitinder S., additional

Published
2017
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37. 3-Year Outcomes in High-Risk Patients Who Underwent Surgical or Transcatheter Aortic Valve Replacement

Author

Deeb, G. Michael, primary, Reardon, Michael J., additional, Chetcuti, Stan, additional, Patel, Himanshu J., additional, Grossman, P. Michael, additional, Yakubov, Steven J., additional, Kleiman, Neal S., additional, Coselli, Joseph S., additional, Gleason, Thomas G., additional, Lee, Joon Sup, additional, Hermiller, James B., additional, Heiser, John, additional, Merhi, William, additional, Zorn, George L., additional, Tadros, Peter, additional, Robinson, Newell, additional, Petrossian, George, additional, Hughes, G. Chad, additional, Harrison, J. Kevin, additional, Maini, Brijeshwar, additional, Mumtaz, Mubashir, additional, Conte, John, additional, Resar, Jon, additional, Aharonian, Vicken, additional, Pfeffer, Thomas, additional, Oh, Jae K., additional, Qiao, Hongyan, additional, Adams, David H., additional, and Popma, Jeffrey J., additional

Published
2016
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38. Phase I study of multi-gene cell therapy in patients with peripheral artery disease

Author

Grossman, P Michael, primary, Mohler, Emile R, additional, Roessler, Blake J, additional, Wilensky, Robert L, additional, Levine, Bruce L, additional, Woo, Edward Y, additional, Upchurch, Gilbert R, additional, Schneiderman, Jacob, additional, Koren, Belly, additional, Hutoran, Marina, additional, Gershstein, Diana, additional, and Flugelman, Moshe Y, additional

Published
2015
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39. If not now, when? Prescription of evidence-based medical therapy prior to hospital discharge increases utilization at 6 months in patients with symptomatic peripheral artery disease

Author

Renard, Brian M, primary, Seth, Milan, additional, Share, David, additional, Aronow, Herb D, additional, Laveroni, Eugene W, additional, De Gregorio, Michele, additional, Hans, Sachinder S, additional, Henke, Peter K, additional, Gurm, Hitinder S, additional, and Grossman, P Michael, additional

Published
2015
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42. Phase I study of multi-gene cell therapy in patients with peripheral artery disease.

Author

Grossman, P. Michael, Mohler, Emile R., Roessler, Blake J., Wilensky, Robert L., Levine, Bruce L., Woo, Edward Y., Upchurch, Gilbert R., Schneiderman, Jacob, Koren, Belly, Hutoran, Marina, Gershstein, Diana, and Flugelman, Moshe Y.

Subjects
*ARTERIAL disease treatment, *CELLULAR therapy, *GENE therapy, *VASCULAR endothelial growth factors, *ANGIOPOIETIN-1
Abstract

Alternative treatment strategies for claudication are needed and cell-based therapies designed to induce angiogenesis are promising. The purpose of this report was to conduct a Phase I safety, dose-escalating, non-randomized, open-label study of autologous, fully differentiated venous endothelial and smooth muscle cells called MultiGeneAngio (MGA) for claudication due to peripheral artery disease. Twelve subjects, at two centers, received a single intra-arterial infusion of a suspension of equal amounts of transduced autologous venous smooth muscle cells expressing vascular endothelial growth factor (VEGF165) and endothelial cells expressing angiopoietin-1 (Ang-1) (Cohort 1: 1 × 107, Cohort 2: 2 × 107, Cohort 3: 5 × 107, Cohort 4: 7 × 107). The treatment was given unblinded and in the more symptomatic lower extremity. Transduced cells were tested for in vitro doubling time, telomerase activity, and gene expression. The main outcomes were clinical safety and tolerability. Other safety measures included ankle–brachial index (ABI) and walking time on a treadmill. All subjects were male (mean age 60 ± 5 years) including 25% with diabetes mellitus. At 1-year follow-up, there was one serious adverse event possibly related to MGA. Safety endpoints including VEGF and Ang-1 plasma protein levels were within normal ranges in all subjects. The mean maximal walking time increased from baseline to 1 year and the index limb ABI was unchanged, indicating no safety concerns. MGA, an autologous, transduced, cell-based therapy was well tolerated and safe in this Phase I study. Further evaluation is warranted in randomized human studies. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT00390767. [ABSTRACT FROM AUTHOR]

Published
2016
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47. Defining the Optimal Degree of Heparin Anticoagulation for Peripheral Vascular Interventions

Author

Kasapis, Christos, primary, Gurm, Hitinder S., additional, Chetcuti, Stanley J., additional, Munir, Khan, additional, Luciano, Ann, additional, Smith, Dean, additional, Aronow, Herbert D., additional, Kassab, Elias H., additional, Knox, Michael F., additional, Moscucci, Mauro, additional, Share, David, additional, and Grossman, P. Michael, additional

Published
2010
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