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17 results on '"Grosberg, Lauren E."'

1. High-fidelity reproduction of visual signals by electrical stimulation in the central primate retina

Author

Gogliettino, Alex R., primary, Madugula, Sasidhar S., additional, Grosberg, Lauren E., additional, Vilkhu, Ramandeep S., additional, Brown, Jeff, additional, Nguyen, Huy, additional, Kling, Alexandra, additional, Hottowy, Paweł, additional, Dąbrowski, Władysław, additional, Sher, Alexander, additional, Litke, Alan M., additional, and Chichilnisky, E.J., additional

Published
2023
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2. Inference of Electrical Stimulation Sensitivity from Recorded Activity of Primate Retinal Ganglion Cells.

Author

Madugula, Sasidhar S., Vilkhu, Ramandeep, Shah, Nishal P., Grosberg, Lauren E., Kling, Alexandra, Gogliettino, Alex R., Huy Nguyen, Hottowy, Paweł, Sher, Alexander, Litke, Alan M., and Chichilnisky, E. J.

Subjects
RETINAL ganglion cells, ELECTRIC stimulation, NEURAL circuitry, PRIMATES, RETINA, RETINAL blood vessels, CONTRAST sensitivity (Vision)
Abstract

High-fidelity electronic implants can in principle restore the function of neural circuits by precisely activating neurons via extracellular stimulation. However, direct characterization of the individual electrical sensitivity of a large population of target neurons, to precisely control their activity, can be difficult or impossible. A potential solution is to leverage biophysical principles to infer sensitivity to electrical stimulation from features of spontaneous electrical activity, which can be recorded relatively easily. Here, this approach is developed and its potential value for vision restoration is tested quantitatively using large-scale multielectrode stimulation and recording from retinal ganglion cells (RGCs) of male and female macaque monkeys ex vivo. Electrodes recording larger spikes from a given cell exhibited lower stimulation thresholds across cell types, retinas, and eccentricities, with systematic and distinct trends for somas and axons. Thresholds for somatic stimulation increased with distance from the axon initial segment. The dependence of spike probability on injected current was inversely related to threshold, and was substantially steeper for axonal than somatic compartments, which could be identified by their recorded electrical signatures. Dendritic stimulation was largely ineffective for eliciting spikes. These trends were quantitatively reproduced with biophysical simulations. Results from human RGCs were broadly similar. The inference of stimulation sensitivity from recorded electrical features was tested in a data-driven simulation of visual reconstruction, revealing that the approach could significantly improve the function of future high-fidelity retinal implants. [ABSTRACT FROM AUTHOR]

Published
2023
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3. High-fidelity reproduction of visual signals by electrical stimulation in the central primate retina

Author

Gogliettino, Alex R., primary, Madugula, Sasidhar S., additional, Grosberg, Lauren E., additional, Vilkhu, Ramandeep S., additional, Brown, Jeff, additional, Nguyen, Huy, additional, Kling, Alexandra, additional, Hottowy, Paweł, additional, Dąbrowski, Władysław, additional, Sher, Alexander, additional, Litke, Alan M., additional, and Chichilnisky, E.J., additional

Published
2022
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9. Activation of ganglion cells and axon bundles using epiretinal electrical stimulation

Author

Grosberg, Lauren E., primary, Ganesan, Karthik, additional, Goetz, Georges A., additional, Madugula, Sasidhar S., additional, Bhaskhar, Nandita, additional, Fan, Victoria, additional, Li, Peter, additional, Hottowy, Pawel, additional, Dabrowski, Wladyslaw, additional, Sher, Alexander, additional, Litke, Alan M., additional, Mitra, Subhasish, additional, and Chichilnisky, E. J., additional

Published
2017
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11. Selective activation of ganglion cells without axon bundles using epiretinal electrical stimulation

Author

Grosberg, Lauren E., primary, Ganesan, Karthik, additional, Goetz, Georges A., additional, Madugula, Sasidhar, additional, Bhaskar, Nandita, additional, Fan, Victoria, additional, Li, Peter, additional, Hottowy, Paweł, additional, Dabrowski, Władysław, additional, Sher, Alexander, additional, Litke, Alan M., additional, Mitra, Subhasish, additional, and Chichilnisky, E.J., additional

Published
2016
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16. Optical Imaging and Microscopy of the Living Brain

Author

Hillman, Elizabeth M. C., primary, Chen, Brenda R., additional, Bouchard, Matthew B., additional, Grosberg, Lauren E., additional, Kozberg, Mariel G., additional, Rayshubskiy, Aleksandr, additional, Galwaduge, Pubudu T., additional, Muldoon, Timothy, additional, Ramirez, Evelyn, additional, Kim, Sharon, additional, and Liu, Angela, additional

Published
2012
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