38 results on '"Grootswagers, Pol"'
Search Results
2. Discovering the direct relations between nutrients and epigenetic ageing
- Author
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Grootswagers, Pol, Bach, Daimy, Biemans, Ynte, Behrouzi, Pariya, Horvath, Steve, Kramer, Charlotte S., Liu, Simin, Manson, JoAnn E., Shadyab, Aladdin H., Stewart, James D., Whitsel, Eric, Yang, Bo, and de Groot, Lisette
- Published
- 2024
- Full Text
- View/download PDF
3. Meal Protein Quality Score: A Novel Tool to Evaluate Protein Quantity and Quality of Meals
- Author
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Grootswagers, Pol, Højlund Christensen, Sine, Timmer, Marielle, Riley, William, de Groot, Lisette, and Tetens, Inge
- Published
- 2024
- Full Text
- View/download PDF
4. The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study
- Author
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Tore, Elena C., Eussen, Simone J.P.M., Bastani, Nasser E., Dagnelie, Pieter C., Elshorbagy, Amany K., Grootswagers, Pol, Kožich, Viktor, Olsen, Thomas, Refsum, Helga, Retterstøl, Kjetil, Stehouwer, Coen DA., Stolt, Emma T.K., Vinknes, Kathrine J., and van Greevenbroek, Marleen M.J.
- Published
- 2023
- Full Text
- View/download PDF
5. Meal Protein Quality Score: A novel tool to evaluate protein quantity and quality of meals
- Author
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Grootswagers, Pol, primary, Christensen, Sine Højlund, additional, Timmer, Marielle, additional, Riley, William, additional, de Groot, Lisette, additional, and Tetens, Inge, additional
- Published
- 2024
- Full Text
- View/download PDF
6. Discussion on protein recommendations for supporting muscle and bone health in older adults: a mini review
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Groenendijk, Inge, primary, de Groot, Lisette C. P. G. M., additional, Tetens, Inge, additional, and Grootswagers, Pol, additional
- Published
- 2024
- Full Text
- View/download PDF
7. Identifying the relation between food groups and biological ageing: a data-driven approach
- Author
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Biemans, Ynte, primary, Bach, Daimy, additional, Behrouzi, Pariya, additional, Horvath, Steve, additional, Kramer, Charlotte S, additional, Liu, Simin, additional, Manson, JoAnn E, additional, Shadyab, Aladdin H, additional, Stewart, James, additional, Whitsel, Eric A, additional, Yang, Bo, additional, de Groot, Lisette, additional, and Grootswagers, Pol, additional
- Published
- 2024
- Full Text
- View/download PDF
8. Nutrition and Exercise to Maintain Physical Functioning During Ageing
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Grootswagers, Pol, Mensink, Marco, de Groot, Lisette, Rattan, Suresh I.S., Series Editor, Barbagallo, Mario, Editorial Board Member, Çakatay, Ufuk, Editorial Board Member, Fraifeld, Vadim E., Editorial Board Member, Fülöp, Tamàs, Editorial Board Member, Gruber, Jan, Editorial Board Member, Jin, Kunlin, Editorial Board Member, Kaul, Sunil, Editorial Board Member, Kaur, Gurcharan, Editorial Board Member, Le Bourg, Eric, Editorial Board Member, Lopez Lluch, Guillermo, Editorial Board Member, Moskalev, Alexey, Editorial Board Member, Nehlin, Jan, Editorial Board Member, Pawelec, Graham, Editorial Board Member, Rizvi, Syed Ibrahim, Editorial Board Member, Sholl, Jonathan, Editorial Board Member, Stambler, Ilia, Editorial Board Member, Szczerbińska, Katarzyna, Editorial Board Member, Trougakos, Ioannis P., Editorial Board Member, Wadhwa, Renu, Editorial Board Member, Wnuk, Maciej, Editorial Board Member, and Rattan, Suresh I. S., editor
- Published
- 2021
- Full Text
- View/download PDF
9. Diets in Dutch hospitals : Setting the scene for healthy, protein adequate, and sustainable menus
- Author
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Bannenberg, Celia, Geleijnse, Marianne, Grootswagers, Pol, Lensink, Mariska, van der Schouw, Yvonne T., Kok, Annemieke, Dermody, Brian J., Bolat, Esra, Pot, Gerda K., de Koning, Iris, Kuipers, Jelte, Verhage, Charlotte, Biesbroek, Sander, Bannenberg, Celia, Geleijnse, Marianne, Grootswagers, Pol, Lensink, Mariska, van der Schouw, Yvonne T., Kok, Annemieke, Dermody, Brian J., Bolat, Esra, Pot, Gerda K., de Koning, Iris, Kuipers, Jelte, Verhage, Charlotte, and Biesbroek, Sander
- Published
- 2024
10. O.4.1-5 An online lifestyle intervention consisting of resistance exercise and advice on protein intake improves leg muscle strength and physical functioning in older adults
- Author
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Dorhout, Berber, primary, Grootswagers, Pol, additional, and Wezenbeek, Nick, additional
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- 2023
- Full Text
- View/download PDF
11. The co-creation of a digital tool that ensures sufficient protein quality in plant-based meals of older adults; a User-Centered Design Approach (Preprint)
- Author
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van Dam, Lotte, primary, Christensen, Sine Højlund, additional, Tetens, Inge, additional, Riley III, William, additional, Timmer, Mariëlle, additional, Suciu Jr, George, additional, Marin, Iuliana, additional, De Groot, Lisette, additional, and Grootswagers, Pol, additional
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- 2023
- Full Text
- View/download PDF
12. Protein intake and bone mineral density: Cross‐sectional relationship and longitudinal effects in older adults
- Author
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Groenendijk, Inge, Grootswagers, Pol, Santoro, Aurelia, Franceschi, Claudio, Bazzocchi, Alberto, Meunier, Nathalie, Caille, Aurélie, Malpuech‐Brugere, Corinne, Bialecka‐Debek, Agata, Pietruszka, Barbara, Fairweather‐Tait, Susan, Jennings, Amy, de Groot, Lisette C.P.G.M., Groenendijk, Inge, Grootswagers, Pol, Santoro, Aurelia, Franceschi, Claudio, Bazzocchi, Alberto, Meunier, Nathalie, Caille, Aurélie, Malpuech‐Brugere, Corinne, Bialecka‐Debek, Agata, Pietruszka, Barbara, Fairweather‐Tait, Susan, Jennings, Amy, and de Groot, Lisette C.P.G.M.
- Abstract
Background: There are several mechanisms via which increased protein intake might maintain or improve bone mineral density (BMD), but current evidence for an association or effect is inconclusive. The objectives of this study were to investigate the association between dietary protein intake (total, plant and animal) with BMD (spine and total body) and the effects of protein supplementation on BMD.Methods: Individual data from four trials that included either (pre-)frail, undernourished or healthy older adults (aged ≥65 years) were combined. Dietary intake was assessed with food records (2, 3 or 7 days) and BMD with dual-energy X-ray absorptiometry (DXA). Associations and effects were assessed by adjusted linear mixed models.Results: A total of 1570 participants [57% women, median (inter-quartile range): age 71 (68–75) years] for which at least total protein intake and total body BMD were known were included in cross-sectional analyses. In fully adjusted models, total protein intake was associated with higher total body and spine BMD [beta (95% confidence interval): 0.0011 (0.0006–0.0015) and 0.0015 (0.0007–0.0023) g/cm2, respectively]. Animal protein intake was associated with higher total body and spine BMD as well [0.0011 (0.0007–0.0016) and 0.0017 (0.0010–0.0024) g/cm2, respectively]. Plant protein intake was associated with a lower total body and spine BMD [−0.0010 (−0.0020 to −0.0001) and −0.0019 (−0.0034 to −0.0004) g/cm2, respectively]. Associations were similar between sexes. Participants with a high ratio of animal to plant protein intake had higher BMD. In participants with an adequate calcium intake and sufficient serum 25(OH)D concentrations, the association between total protein intake with total body and spine BMD became stronger. Likewise, the association between animal protein intake with total body BMD was stronger. In the longitudinal analyses, 340 participants [58% women, median (inter-quartile range): age 75 (70–81) years] were included. Interve
- Published
- 2023
13. Switching towards More Plant-Based Diets in Older Adults: Implications for Protein Intake and Protein Quality Based on a Simulation Study
- Author
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Grootswagers, Pol, Borkent, Jos, Timmer, Marielle, Riley, William, Linschooten, Joost, Roodenburg, Annet, Tetens, Inge, De van der Schueren, Marian, Grootswagers, Pol, Borkent, Jos, Timmer, Marielle, Riley, William, Linschooten, Joost, Roodenburg, Annet, Tetens, Inge, and De van der Schueren, Marian
- Abstract
Rationale: An adequate amount of good-quality protein (P) is essential to remain fit and healthy at an older age. Animal-based proteins (ABPs) are of high quality and provide nearly 60% of the P intake in older adults. It is unclear if an adequate P intake can be achieved when ABPs are replaced by vegetarian (Veg) or plant-based (Plant) alternatives. Methods: A simulation study was performed based on dietary intake data from the Dutch National food consumption (DNFC) 2019–2021 (n = 607, age ≥ 65 years). In five scenarios, animal protein intake was replaced by vegetable protein. The scenario diets included vegetarian, flexitarian (two levels), pescatarian and vegan. Protein quality was measured by the Meal Protein Quality Score (MPQS), a score that ranges from 0–100 and takes into account protein digestibility, body-weight based amino acid requirements, and time window of complementation. Results: Total P and MPQS remained stable over all non-vegan plant-based scenarios, but showed a large decrease in the vegan scenario. Conclusions: shifting to a fully vegan diet severely compromises total protein intake and protein quality in older adults, whereas shifting to a vegetarian or flexitarian diet does not.
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- 2023
14. Protein intake and bone mineral density: Cross‐sectional relationship and longitudinal effects in older adults
- Author
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Groenendijk, Inge, primary, Grootswagers, Pol, additional, Santoro, Aurelia, additional, Franceschi, Claudio, additional, Bazzocchi, Alberto, additional, Meunier, Nathalie, additional, Caille, Aurélie, additional, Malpuech‐Brugere, Corinne, additional, Bialecka‐Debek, Agata, additional, Pietruszka, Barbara, additional, Fairweather‐Tait, Susan, additional, Jennings, Amy, additional, and de Groot, Lisette C.P.G.M., additional
- Published
- 2022
- Full Text
- View/download PDF
15. Identifying the interactions between nutrients and biological ageing
- Author
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Grootswagers, Pol, Daimy Bach, Ynte Biemans, and Behrouzi, Pariya
- Subjects
FOS: Computer and information sciences ,Aging ,DNA methylation ,Epigenetic clock ,Bioinformatics ,Dietary habits ,Biological age ,Life Sciences ,PhenoAge ,Exploratory ,FOS: Law ,Diseases ,nutriNetwork ,Epigenetic aging ,Medicine and Health Sciences ,data-driven ,Copula Graphical Model ,Graphical Model ,Women's Health Initiative ,Law ,Dietetics and Clinical Nutrition ,Nutrition ,Food Science - Abstract
Ageing is seen as one of the greatest challenges of the coming decades, as it leads to enormous financial and social burden (Prince et al., 2015). Globally, the gap in lifespan and health span between high and low socioeconomic classes has been growing for the last decades (Partridge et al., 2018). The main differences between these classes are found in lifestyle and environment, strengthening the observation that genetics only explain a minor proportion of lifespan variation (Fong et al., 2021; Kaplanis et al., 2018). The heterogeneity in the ageing process (and consequential susceptibility to diseases) between individuals renders chronological age unequipped to accurately represent the ageing process (Levine et al., 2018). As determining causes of accelerated or decelerated ageing rates has potential social, economic, and public health benefits, researchers have been studying alternative methods that can more accurately represent the ageing process. To date, the most accurate biomarker of human ageing are so called epigenetic clocks (Levine et al., 2018), which represents one’s biological age. Epigenetic clocks estimate a person’s biological age by analyzing the degree of methylation on a set of CpG sites determined by machine learning (Horvath & Raj, 2018). Briefly, DNA methylation is the process that involves the transfer of a methyl-group onto the C5 position of cytosine, forming 5-methylcytosine (5mC). This process, like other epigenetic modifications, regulates gene expression without changing the DNA sequence (Abdul et al., 2017). Interestingly, epigenetic clocks show excellent correlations with chronological age, are able to predict illness and death and can be ‘rewound’ by healthy lifestyle interventions, such as a Mediterranean diet (Kresovich et al., 2022; Lu et al., 2019). Additionally, a study from Quach et al. (2017) investigated the relationships between epigenetic age acceleration in blood and dietary variables, education, alcohol, and exercise by using data from older women within the Women's Health Initiative (WHI) from two large epidemiological cohorts. The main findings showed a relatively strong correlation between higher intake of fish, vegetables, fruits and poultry and decelerated epigenetic ageing, reflecting a potential health benefit by specific dietary elements (Quach et al., 2017). These results are only the first examples of an emerging new field in human ageing research: making use of epigenetic clocks to identify dietary habits that protect against age-acceleration. A limitation of the study method of Quach et al. (2017) and other studies investigating epigenetic ageing, is the hypothesis-driven approach, since it limits the amount of nutrients that can be identified to play a role in biological ageing. With an entirely data-driven approach in a suitable dataset, the importance of specific dietary habits in light of ageing can be identified in a more objective and open-minded fashion. After all, although various studies have shown the causal relationship between a healthy lifestyle and slowing down of DNA methylation-based biomarkers of biological ageing (Fiorito et al., 2021; Fitzgerald et al., 2021), the effects of specific nutrients that could slow down ageing are still unclear. With a data-driven approach, which considers the full range of nutrients, new doors in the field of nutrition and ageing research can be opened. These leads can be further unraveled in hypothesis-driven, observational or interventional study designs. For optimal data-driven analyses, the data should be of high quality, with epigenetic age data of many participants, and with extensive information on diet, physical activity, smoking and drinking habits, as well as general covariates. Therefore, using the extensive data of the WHI in which these high-quality data are available in a large sample of older women would be of great value for our research. We propose to use Copula Graphical Modeling (CGM), which is a network analysis method that copes with non-gaussian, ordinal and count data, as well as with complex inter-nutrient relationships. This flexibility makes CGM highly applicable in nutritional epidemiology. CGM allows to identify direct relationships between dietary factors and biological ageing, while adjusting for every other variable present in the dataset (Lauritzen, 1996; Behrouzi et al., 2020), thereby preventing subjective confounder selection while allowing us to include all measured nutrient intake in the networks. In previous unpublished work, we successfully carried out CGM analyses on a small dataset with lifestyle factors and biological age. For this study, we aim to repeat the methodology in a large subsample of the WHI, to discover nutritional and lifestyle factors that influence the rate of epigenetic ageing. References . Abdul, Q. A., et al. (2017). Epigenetic modifications of gene expression by lifestyle and environment. Archives of Pharmacal Research 40(11): 1219-1237. https://doi.org/10.1007/s12272-017-0973-3 Behrouzi, P., Grootswagers, P., Keizer, P. L. C., Smeets, E. T. H. C., Feskens, E. J. M., de Groot, L. C. P. G. M., van Eeuwijk, F. A. (2020). Dietary Intakes of Vegetable Protein, Folate, and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models. Journal of Nutrition, 150(3). https://doi.org/10.1093/jn/nxz269 Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, et al. DNA methylation aging clocks: challenges and recommendations. Genome Biology. 2019;20(1):249. Fiorito, G., et al. (2021). "DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study." Aging Cell 20(10): e13439. https://doi.org/10.1111/acel.13439 Fong, B. Y. F., et al. (2021). A Review Study of a Green Diet and Healthy Ageing. International Journal of Environmental Research and Public Health 18(15): 8024. https://doi.org/10.3390/ijerph18158024 Horvath, S. and K. Raj (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics 19(6): 371-384. https://doi.org/10.1038/s41576-018-0004-3 Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY) 10(4): 573-591. http://doi.org/10.18632/aging.101414 Kresovich, J. K., et al. (2022). Healthy eating patterns and epigenetic measures of biological age. Am J Clin Nutr 115(1): 171-179. http://doi.org/10.1093/ajcn/nqab307 Kaplanis, J., et al. (2018). Quantitative analysis of population-scale family trees with millions of relatives. Science 360(6385): 171-175. https://www.science.org/doi/abs/10.1126/science.aam9309 Lauritzen, S. L. (1996). Graphical models. Claren- don Press. Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner, A. P., Aviv, A., Lohman, K., Liu, Y., Ferrucci, L., & Horvath, S. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging, 10(4), 573–591. https://doi.org/10.18632/aging.101414 Lu, A. T., et al. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY) 11(2): 303-327. http://doi.org/10.18632/aging.101684 Partridge, L., et al. (2018). Facing up to the global challenges of ageing. Nature 561(7721): 45-56. https://doi.org/10.1038/s41586-018-0457-8 Prince, M. J., et al. (2015). The burden of disease in older people and implications for health policy and practice. The Lancet 385(9967): 549-562. https://doi.org/10.1016/S0140-6736(14)61347-7 Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168. PMID: 28198702; PMCID: PMC5361673.
- Published
- 2023
- Full Text
- View/download PDF
16. Identifying the interactions between dietary habits and biological aging
- Author
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Ynte Biemans, Grootswagers, Pol, Daimy Bach, and Behrouzi, Pariya
- Subjects
Statistics and Probability ,Aging ,DNA methylation ,Statistical Models ,Epigenetic ageing ,Biological age ,Life Sciences ,PhenoAge ,Genetics and Genomics ,Medicine and Health Sciences ,Physical Sciences and Mathematics ,Copula Graphical Model ,Dietetics and Clinical Nutrition ,Nutrition ,Food Science - Abstract
Aging is seen as one of the greatest challenges of the coming decades, as it leads to enormous financial and social burden (Prince et al., 2015). Globally, the gap in lifespan and health span between high and low socioeconomic classes has been growing for the last decades (Partridge et al., 2018). The main differences between these classes are found in lifestyle and environment, strengthening the observation that genetics only explain a minor proportion of lifespan variation (Fong et al., 2021; Kaplanis et al., 2018). The heterogeneity in the aging process (and consequential susceptibility to diseases) between individuals renders chronological age unequipped to accurately represent the aging process (Levine et al., 2018). As determining causes of accelerated or decelerated aging rates has potential social, economic, and public health benefits, researchers have been studying alternative methods that can more accurately represent the aging process. To date, the most accurate biomarker of human aging are so called epigenetic clocks (Levine et al., 2018), which represents one’s biological age. Epigenetic clocks estimate a person’s biological age by analyzing the degree of methylation on a set of CpG sites determined by machine learning (Horvath & Raj, 2018). Briefly, DNA methylation is the process that involves the transfer of a methyl-group onto the C5 position of cytosine, forming 5-methylcytosine (5mC). This process, like other epigenetic modifications, regulates gene expression without changing the DNA sequence (Abdul et al., 2017). Interestingly, epigenetic clocks show excellent correlations with chronological age, are able to predict illness and death and can be ‘rewound’ by healthy lifestyle interventions, such as a Mediterranean diet (Kresovich et al., 2022; Lu et al., 2019). Additionally, a study from Quach et al. (2017) investigated the relationships between epigenetic age acceleration in blood and dietary variables, education, alcohol, and exercise by using data from older women within the Women's Health Initiative (WHI) from two large epidemiological cohorts. The main findings showed a relatively strong correlation between higher intake of fish, vegetables, fruits and poultry and decelerated epigenetic ageing, reflecting a potential health benefit by specific dietary elements (Quach et al., 2017). These results are only the first examples of an emerging new field in human aging research: making use of epigenetic clocks to identify dietary habits that protect against age-acceleration. A limitation of the study method of Quach et al. (2017) and other studies investigating epigenetic ageing, is the hypothesis-driven approach, since it limits the amount of nutrients and food groups that can be identified to play a role in biological ageing. With an entirely data-driven approach in a suitable dataset, the importance of specific dietary habits in light of ageing can be identified in a more objective and open-minded fashion. After all, although various studies have shown the causal relationship between a healthy lifestyle and slowing down of DNA methylation-based biomarkers of biological aging (Fiorito et al., 2021; Fitzgerald et al., 2021), the effects of specific nutrients and foods that could slow down aging are still unclear. In addition, as nutrient databases often provide limited information on bioactive compounds, food matrices, and potential other interactions among substances within foods, it is valuable to also explore whether specific food groups relate to the pace of biological aging. With a data-driven approach, which considers the full range of nutrients and food groups, new doors in the field of nutrition and ageing research can be opened. These leads can be further unraveled in hypothesis-driven, observational or interventional study designs. For optimal data-driven analyses, the data should be of high quality, with epigenetic age data of many participants, and with extensive information on diet, physical activity, smoking and drinking habits, as well as general covariates. Therefore, using the extensive data of the WHI in which these high-quality data are available in a large sample of older women would be of great value for our research. We propose to use Copula Graphical Modeling (CGM), which is a network analysis method that copes with non-gaussian, ordinal and count data, as well as with complex inter-nutrient relationships. This flexibility makes CGM highly applicable in nutritional epidemiology. CGM allows to identify direct relationships between dietary factors and biological aging, while adjusting for every other variable present in the dataset (Lauritzen, 1996; Behrouzi et al., 2020), thereby preventing subjective confounder selection while allowing us to include all measured nutrient and food group intake in the networks. In previous unpublished work, we successfully carried out CGM analyses on a small dataset with lifestyle factors and biological age. For this study, we aim to repeat the methodology in a large subsample of the WHI, to discover nutritional and lifestyle factors that influence the rate of epigenetic aging. References . Abdul, Q. A., et al. (2017). Epigenetic modifications of gene expression by lifestyle and environment. Archives of Pharmacal Research 40(11): 1219-1237. https://doi.org/10.1007/s12272-017-0973-3 Behrouzi, P., Grootswagers, P., Keizer, P. L. C., Smeets, E. T. H. C., Feskens, E. J. M., de Groot, L. C. P. G. M., van Eeuwijk, F. A. (2020). Dietary Intakes of Vegetable Protein, Folate, and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models. Journal of Nutrition, 150(3). https://doi.org/10.1093/jn/nxz269 Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, et al. DNA methylation aging clocks: challenges and recommendations. Genome Biology. 2019;20(1):249. Fiorito, G., et al. (2021). "DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study." Aging Cell 20(10): e13439. https://doi.org/10.1111/acel.13439 Fong, B. Y. F., et al. (2021). A Review Study of a Green Diet and Healthy Ageing. International Journal of Environmental Research and Public Health 18(15): 8024. https://doi.org/10.3390/ijerph18158024 Horvath, S. and K. Raj (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics 19(6): 371-384. https://doi.org/10.1038/s41576-018-0004-3 Levine, M. E., et al. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY) 10(4): 573-591. http://doi.org/10.18632/aging.101414 Kresovich, J. K., et al. (2022). Healthy eating patterns and epigenetic measures of biological age. Am J Clin Nutr 115(1): 171-179. http://doi.org/10.1093/ajcn/nqab307 Kaplanis, J., et al. (2018). Quantitative analysis of population-scale family trees with millions of relatives. Science 360(6385): 171-175. https://www.science.org/doi/abs/10.1126/science.aam9309 Lauritzen, S. L. (1996). Graphical models. Claren- don Press. Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner, A. P., Aviv, A., Lohman, K., Liu, Y., Ferrucci, L., & Horvath, S. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging, 10(4), 573–591. https://doi.org/10.18632/aging.101414 Lu, A. T., et al. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY) 11(2): 303-327. http://doi.org/10.18632/aging.101684 Partridge, L., et al. (2018). Facing up to the global challenges of ageing. Nature 561(7721): 45-56. https://doi.org/10.1038/s41586-018-0457-8 Prince, M. J., et al. (2015). The burden of disease in older people and implications for health policy and practice. The Lancet 385(9967): 549-562. https://doi.org/10.1016/S0140-6736(14)61347-7 Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168. PMID: 28198702; PMCID: PMC5361673.
- Published
- 2023
- Full Text
- View/download PDF
17. Perspective: Vegan Diets for Older Adults? A Perspective On the Potential Impact On Muscle Mass and Strength
- Author
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Domić, Jacintha, primary, Grootswagers, Pol, additional, van Loon, Luc J C, additional, and de Groot, Lisette C P G M, additional
- Published
- 2022
- Full Text
- View/download PDF
18. Relative Validity and Reliability of Isometric Lower Extremity Strength Assessment in Older Adults by Using a Handheld Dynamometer
- Author
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Grootswagers, Pol, Vaes, Anouk M.M., Hangelbroek, Roland, Tieland, Michael, van Loon, Luc J.C., de Groot, Lisette C.P.G.M., Grootswagers, Pol, Vaes, Anouk M.M., Hangelbroek, Roland, Tieland, Michael, van Loon, Luc J.C., and de Groot, Lisette C.P.G.M.
- Abstract
Background: Handheld dynamometry (HHD) is a practical alternative to traditional testing of lower extremity strength. However, its reliability and validity across different populations and settings are not clear. Hypothesis: We hypothesize that HHD is a valid and reliable device to assess lower extremity strength in a population of older adults. Study Design: Cross-sectional/cohort. Level of Evidence: Level 3. Methods: This study included 258 older adults (≥65 years). Isometric knee extension and flexion force were measured by 1 examiner, using an HHD (n = 222), including 3 repetitions to calculate within-day intrarater reliability. These measurements were repeated by the examiner in a subgroup (n = 23) to analyze intrarater reliability over a test-retest period of on average 8 weeks. In addition, HHD force measures were performed by a second examiner (n = 29) to analyze interrater reliability. In another subgroup (n = 77), isometric knee extension and flexion torque were measured by 1 examiner using both the HHD and Biodex System 4 to assess relative validity. Results: HHD and Biodex measurements were highly correlated and showed excellent concurrent validity. HHD systematically overestimated torque as compared with Biodex by 8 N·m on average. Same-day intrarater intraclass correlation coefficients (ICCs) ranged from 0.97 to 0.98. Interrater reliability ICCs ranged from 0.83 to 0.95. Conclusion: HHD represents a reliable and valid alternative to Biodex to rank individuals on leg strength, or to assess within-person changes in leg strength over time, because of the high validity and reliability. The HHD is less suited for absolute strength assessment because of significant systematic overestimations. Clinical Relevance: Clinicians are encouraged to use HHD to rank older adults on leg strength, or to assess within-person changes in leg strength over time, but not to compare readings with cut-offs or normative values.
- Published
- 2022
19. Perspective: Vegan Diets for Older Adults? A Perspective On the Potential Impact On Muscle Mass and Strength
- Author
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Domić, Jacintha, Grootswagers, Pol, van Loon, Luc J.C., De groot, Lisette, Domić, Jacintha, Grootswagers, Pol, van Loon, Luc J.C., and De groot, Lisette
- Abstract
Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. Concurrently, older adults are recommended to consume an adequate amount of high-quality dietary protein for the prevention of age-related muscle loss. In the current Perspective article, we discuss why it may not be preferred to consume a vegan diet at an older age. Our perspective is based on the proposed lower bioavailability and functionality of proteins in a vegan diet due to the matrix of the whole-food protein sources, the lower essential amino acid (EAA) content, and specific EAA deficiencies in proteins derived from plant-based foods. We propose that a vegan diet increases the risk of an inadequate protein intake at an older age and that current strategies to improve the anabolic properties of plant-based foods are not feasible for many older adults. We provide recommendations for further research to substantiate the remaining knowledge gaps regarding the consequences of a vegan diet on skeletal muscle mass and strength at an older age.
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- 2022
20. Relative Validity and Reliability of Isometric Lower Extremity Strength Assessment in Older Adults by Using a Handheld Dynamometer
- Author
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Grootswagers, Pol, primary, Vaes, Anouk M. M., additional, Hangelbroek, Roland, additional, Tieland, Michael, additional, van Loon, Luc J. C., additional, and de Groot, Lisette C. P. G. M., additional
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- 2022
- Full Text
- View/download PDF
21. Nutritional concerns later in life
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Grootswagers, Pol, primary and de Groot, Lisette C. P. G. M., additional
- Published
- 2021
- Full Text
- View/download PDF
22. Vitamin B-6 intake is related to physical performance in European older adults : results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study
- Author
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Grootswagers, Pol, Mensink, Marco, Berendsen, Agnes A.M., Deen, Carolien P.J., Kema, Ido P., Bakker, Stephan J.L., Santoro, Aurelia, Franceschi, Claudio, Meunier, Nathalie, Malpuech-Brugère, Corinne, Bialecka-Debek, Agata, Rolf, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Feskens, Edith J.M., Groot, Lisette C.P.G.M., de, Grootswagers, Pol, Mensink, Marco, Berendsen, Agnes A.M., Deen, Carolien P.J., Kema, Ido P., Bakker, Stephan J.L., Santoro, Aurelia, Franceschi, Claudio, Meunier, Nathalie, Malpuech-Brugère, Corinne, Bialecka-Debek, Agata, Rolf, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Feskens, Edith J.M., and Groot, Lisette C.P.G.M., de
- Abstract
BACKGROUND: Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. OBJECTIVES: The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations. METHODS: We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n = 1249 healthy older adults (aged 65-79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical performance battery and handgrip dynamometry. Associations were assessed by adjusted linear mixed models. RESULTS: Intake of vitamin B-6 was related to lower chair rise test time [β: -0.033 ± 0.016 s (log); P = 0.043]. Vitamin B-6 intake was also significantly associated with handgrip strength, but for this association, a significant interaction effect between vitamin B-6 intake and physical activity level was found. In participants with the lowest level of physical activity, higher intake of vitamin B-6 tended to be associated with greater handgrip strength (β: 1.5 ± 0.8 kg; P = 0.051), whereas in participants in the highest quartile of physical activity, higher intake was associated with lower handgrip strength (β: -1.4 ± 0.7 kg; P = 0.041). No evidence was found for an association between intake of niacin, vitamin B-12, or folate and physical performance or for mediation by niacin status or homocysteine concentrations. CONCLUSIONS: Vitamin B-6 intake was a
- Published
- 2021
23. A novel oral nutritional supplement improves gait speed and mitochondrial functioning compared to standard care in older adults with (or at risk of) undernutrition: results from a randomized controlled trial
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Grootswagers, Pol, Smeets, Ellen, Oteng, Antwi-Boasiako, de Groot, Lisette, Grootswagers, Pol, Smeets, Ellen, Oteng, Antwi-Boasiako, and de Groot, Lisette
- Abstract
Undernutrition in older adults is mainly addressed by oral nutritional supplements, which do not affect physical functioning. In this study, we tested a novel oral nutritional supplement that included whey and casein protein, ursolic acid, free branch-chained amino acids and vitamin D against a standard supplement. We included older adults (>65y) with (or at risk of) undernutrition (n=82) and randomized them to 12 weeks of novel or standard supplement. Both groups showed significant increases in body mass. No within or between-group differences in lean body mass were observed. Fat mass increased significantly more in the standard than the novel supplement group (time*treatment effect P=0.045). The novel supplement group showed a larger improvement in walking performance on distances of 4m (treatment x time interaction P=0.048) and 400m (treatment x time interaction P=0.038) than the standard treatment group. Gene sets related to mitochondrial functioning and oxidative phosphorylation were upregulated in the novel supplement group and downregulated in the standard supplement group. We conclude that a 12-week intervention with the novel supplement improved walking performance both during short and long distance as compared to a standard supplement, which can largely be explained by increased mitochondrial functioning in the group receiving the novel supplement.
- Published
- 2021
24. Nutritional Concerns Later in Life
- Author
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Grootswagers, Pol, de Groot, Lisette C.P.G.M., Grootswagers, Pol, and de Groot, Lisette C.P.G.M.
- Abstract
In an ageing society, the preservation of health and function is becoming increasingly important. The present paper acknowledges that ageing is malleable and focuses on diets and key nutritional concerns later in life. It presents evidence for the importance of healthful dietary patterns and points towards specific nutritional concerns later in life and conveys three main messages: (1) considering health maintenance and malnutrition risk, both dietary quality in terms of healthful dietary patterns and dietary quantity are important later in life, (2) ageing-related changes in nutrient physiology and metabolism contribute to the risk of inadequacies or deficiencies for specific nutrients, e.g. vitamin D, vitamin B12 and protein and (3) that current food-based dietary guidelines propagate a shift into the direction of Mediterranean type of diets including more plant-based foods. Limited scientific evidence on nutritional requirements of older adults, along with envisaged shifts towards diets rich in plant foods, are challenges that need to be addressed in order to develop tailored nutritional recommendations and dietary guidance for older adults.
- Published
- 2021
25. The effects of a novel oral nutritional supplement as compared to standard care on body composition, physical function and skeletal muscle mRNA expression in Dutch older adults with (or at risk of) undernutrition
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Grootswagers, Pol, Smeets, Ellen, Oteng, Antwi-Boasiako, de Groot, Lisette, Grootswagers, Pol, Smeets, Ellen, Oteng, Antwi-Boasiako, and de Groot, Lisette
- Abstract
In a randomized controlled trial, 82 older adults (>65y) with (or at risk of) undernutrition (n=82) were randomly allocated to 12 weeks of supplementation with a novel supplement (586 kcal, 22 g protein of which 50% whey and 50% casein, 206 mg ursolic acid, 7 g free BCAAs, 11 µg vitamin D) or standard care (600 kcal, 24g protein of which 100% casein, 4 µg vitamin D). Body weight increased significantly in the 12 weeks, both in the intervention group (+1.6 ± 0.2 kg, p<.0001) and in the standard care group (+1.8 ± 0.2 kg, p<.0001). Gait speed during 4m and 400m tests improved over time in the intervention group, whereas the standard care showed no improvements (time*treatment effects 400m: p=0.038 and 4m: p=0.048). Gene sets related to mitochondrial functioning were strongly upregulated in the participants receiving the intervention product. We showed that a novel oral nutritional supplement improves gait speed in older adults via improvements in mitochondrial functioning.
- Published
- 2021
26. A novel oral nutritional supplement improves gait speed and mitochondrial functioning compared to standard care in older adults with (or at risk of) undernutrition: results from a randomized controlled trial
- Author
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Grootswagers, Pol, primary, Smeets, Ellen, additional, Oteng, Antwi-Boasiako, additional, and Groot, Lisette de, additional
- Published
- 2021
- Full Text
- View/download PDF
27. Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study
- Author
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Grootswagers, Pol, primary, Mensink, Marco, additional, Berendsen, Agnes AM, additional, Deen, Carolien PJ, additional, Kema, Ido P, additional, Bakker, Stephan JL, additional, Santoro, Aurelia, additional, Franceschi, Claudio, additional, Meunier, Nathalie, additional, Malpuech-Brugère, Corinne, additional, Bialecka-Debek, Agata, additional, Rolf, Katarzyna, additional, Fairweather-Tait, Susan, additional, Jennings, Amy, additional, Feskens, Edith JM, additional, and de Groot, Lisette CPGM, additional
- Published
- 2021
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- View/download PDF
28. Nutritional strategies to improve muscle quality during ageing
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Grootswagers, Pol, Wageningen University, L. de Groot, and M. Mensink
- Subjects
Life Science ,Nutritional Biology ,VLAG - Abstract
Increased lifespan is a great achievement of humankind, and opens new opportunities for the life of ageing human beings, in part conditional on health and independence. Health and independence are related to physical performance which is often compromised in older adults, to some extent due to age-related decreases in muscle mass and muscle strength decrease. During ageing, muscle strength decreases at a faster rate than muscle mass, indicating a loss in muscle quality. Muscle quality is defined as muscle strength per unit of muscle mass and is determined by factors such as specific muscle fibre atrophy, mitochondrial functioning, neuromuscular functioning and degree of fat infiltration. Targeting the quality of muscle tissue is a promising strategy to improve muscle quality during ageing.An active lifestyle seems to prevent losses in muscle quality to some extent, whereby exercise programs can improve markers of muscle quality. Not many intervention trials have aimed to improve muscle quality via nutrition. However, metabolic aspects play a role in muscle quality, and many nutrients act on pathways that are related to physiological determinants of muscle quality. Together, this gives reasons to pursue the identification of nutritional strategies to target muscle quality. Therefore, in this thesis, we aimed to identify novel nutritional strategies to improve muscle quality and physical performance in older adults.In Chapter 2, we investigated the reliability and validity of handheld dynamometry (HHD) for the assessment of leg strength. Leg strength assessment is proposed to be a better alternative to the often used handgrip strength measurement. However, the current advised equipment to measure leg strength is static and costly, while handgrip strength can be measured with an inexpensive and small device. The results of Chapter 2 show that the HHD is a valid and reliable tool to assess changes in leg strength in older adults or to rank older adults on strength level, indicating that HHD can be used as an alternative to handgrip strength assessment. The results of Chapter 2 are important for the development of leg strength measurements for strength monitoring in older adults.Chapter 3 and Chapter 4 describe the results of two clinical trials aimed at improving physical performance in older adults. In Chapter 3, an intensive exercise and nutrition intervention augmented muscle mass (+5%), strength (+13%), and physical performance (10-20%) of older adults already after four weeks. The findings are relevant and important because short-term interventions like these are urgently needed for the future of prehabilitation. Prehabilitation is a discipline aimed at training patients before planned surgery so that patients lose less muscle mass and strength during hospitalisation.In Chapter 4, a novel medical nutrition product was tested against standard medical nutrition in older adults with (or at risk of) undernutrition. Without a concurrent exercise regimen, this novel medical nutrition treatment appeared to be able to improve walking performance and mitochondrial functioning in this vulnerable group. The improvement in walking performance is of clinical relevance, as it relates to lower chances of future falls, hospitalisation and mortality. Being able to improve physical performance without a concurrent exercise program is an important finding for the field of nutrition and ageing, suggesting that besides exercise interventions, there is a potential for nutritional interventions as well.In Chapter 5 and Chapter 6, we aimed to identify new nutritional targets to improve muscle quality in older adults. Chapter 5 was a hypothesis-driven approach in which we tested the associations between dietary intake of vitamin B3, B6, B12, folate and measures of physical performance in healthy older adults. Chapter 6 was a data-driven approach, in which we tested for associations between all nutrients and measures of physical performance in healthy, frail or malnourished older adults. Chapter 5 identified an association between the intake of vitamin B6 and chair rise test in the full population (3% improvement per mg of vitamin B6) and an association between intake of vitamin B6 and handgrip strength in participants with low physical activity (also a 3% improvement per mg of vitamin B6), but not in those with normal or high physical activity. Chapter 6 also identified an association between vitamin B6 and chair rise test and total physical performance score. Chapter 6 additionally identified associations between intakes of vegetable protein, vitamin B12 and folate with measures of physical performance. Chapter 6 made use of Copula Graphical Modelling, a new methodology with many potential applications for the field of nutritional epidemiology.This thesis adds important knowledge on how to measure muscle quality, which strategies are effective and which nutritional strategies could be further explored in the future. Advancing the integration of muscle quality measurements in the field of nutrition and ageing research can lead to important advances in the quest to find strategies that improve physical performance in older adults. With improved physical performance, older adults are more likely to stay mentally, socially, and physically active. This in turn helps them to age healthily and happily.
- Published
- 2020
29. A 4-week exercise and protein program improves muscle mass and physical functioning in older adults – A pilot study
- Author
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Grootswagers, Pol, Regt, Margot, de, Domić, Jacintha, Dronkers, Jaap, Visser, Marlieke, Witteman, Ben, Hopman, Maria, Mensink, Marco, Grootswagers, Pol, Regt, Margot, de, Domić, Jacintha, Dronkers, Jaap, Visser, Marlieke, Witteman, Ben, Hopman, Maria, and Mensink, Marco
- Abstract
Background: Prehabilitation might attenuate common surgery-induced losses in muscle mass and physical performance. Beneficial effects of physical exercise with protein supplementation have been reported in older adults, but typically after an intervention of at least 12 weeks. The time-window for pre-surgery training is often limited to around 30 days, and it is not known if it is possible to achieve comparable results in such a short time window. Objectives: The aim of this study was to pilot-test the effectiveness of a controlled four-week combined exercise and protein supplementation program on skeletal muscle-related outcomes in a Dutch older adult population. Design: This study was a one-armed pilot trial. Participants: Seventeen older men and women, aged 55-75y, not scheduled for surgery. Intervention: A 4-week intervention program consisting of a twice-weekly supervised resistance and high-intensity aerobic exercise training of 75 min, combined with daily protein supplementation (2 doses of 15.5 g/day at breakfast and lunch). Measurement: After two and four weeks, isometric quadriceps maximal voluntary contraction (MVC) was assessed via Biodex and quadriceps cross-sectional area (CSA) via magnetic resonance imaging. Other outcome measures were handgrip strength, chair rise time and maximal aerobic capacity (VO2-max), as assessed from a submaximal exercise test. Results: Compliance to the supervised training sessions (99.3%) and the protein supplementation (97%) was very high. The 4-week exercise and protein program led to an increase in quadriceps CSA of 2.3 ± 0.7 cm2 (P = 0.008) in the dominant leg and 3.2 ± 0.7 cm2 (P < 0.001) in the non-dominant leg. Isometric quadriceps MVC increased in the dominant leg (Δ14 ± 4 Nm, P = 0.001) and in the non-dominant leg (Δ17 ± 5 Nm, P = 0.003). Chair rise test time improved with −3.8 ± 0.5 s (P < 0.0001), and VO2-max improved with 3.3 ± 1.1 ml/min/kg (P = 0.014). We observed
- Published
- 2020
30. Nutritional strategies to improve muscle quality during ageing
- Author
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de Groot, L., Mensink, M., Grootswagers, Pol, de Groot, L., Mensink, M., and Grootswagers, Pol
- Abstract
Increased lifespan is a great achievement of humankind, and opens new opportunities for the life of ageing human beings, in part conditional on health and independence. Health and independence are related to physical performance which is often compromised in older adults, to some extent due to age-related decreases in muscle mass and muscle strength decrease. During ageing, muscle strength decreases at a faster rate than muscle mass, indicating a loss in muscle quality. Muscle quality is defined as muscle strength per unit of muscle mass and is determined by factors such as specific muscle fibre atrophy, mitochondrial functioning, neuromuscular functioning and degree of fat infiltration. Targeting the quality of muscle tissue is a promising strategy to improve muscle quality during ageing.An active lifestyle seems to prevent losses in muscle quality to some extent, whereby exercise programs can improve markers of muscle quality. Not many intervention trials have aimed to improve muscle quality via nutrition. However, metabolic aspects play a role in muscle quality, and many nutrients act on pathways that are related to physiological determinants of muscle quality. Together, this gives reasons to pursue the identification of nutritional strategies to target muscle quality. Therefore, in this thesis, we aimed to identify novel nutritional strategies to improve muscle quality and physical performance in older adults.In Chapter 2, we investigated the reliability and validity of handheld dynamometry (HHD) for the assessment of leg strength. Leg strength assessment is proposed to be a better alternative to the often used handgrip strength measurement. However, the current advised equipment to measure leg strength is static and costly, while handgrip strength can be measured with an inexpensive and small device. The results of Chapter 2 show that the HHD is a valid and reliable tool to assess changes in leg strength in older adults or to rank older adults on strength level
- Published
- 2020
31. Dietary Intakes of Vegetable Protein, Folate, and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models
- Author
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Behrouzi, Pariya, Grootswagers, Pol, Keizer, Paul L.C., Smeets, Ellen T.H.C., Feskens, Edith J.M., de Groot, Lisette C.P.G.M., van Eeuwijk, Fred A., Behrouzi, Pariya, Grootswagers, Pol, Keizer, Paul L.C., Smeets, Ellen T.H.C., Feskens, Edith J.M., de Groot, Lisette C.P.G.M., and van Eeuwijk, Fred A.
- Abstract
Background: In nutritional epidemiology, dealing with confounding and complex internutrient relations are major challenges. An often-used approach is dietary pattern analyses, such as principal component analysis, to deal with internutrient correlations, and to more closely resemble the true way nutrients are consumed. However, despite these improvements, these approaches still require subjective decisions in the preselection of food groups. Moreover, they do not make efficient use of multivariate dietary data, because they detect only marginal associations. We propose the use of copula graphical models (CGMs) to model and make statistical inferences regarding complex associations among variables in multivariate data, where associations between all variables can be learned simultaneously. Objective: We aimed to reconstruct nutritional intake and physical functioning networks in Dutch older adults by applying a CGM. Methods: We addressed this issue by uncovering the pairwise associations between variables while correcting for the effect of remaining variables. More specifically, we used a CGM to infer the precision matrix, which contains all the conditional independence relations between nodes in the graph. The nonzero elements of the precision matrix indicate the presence of a direct association. We applied this method to reconstruct nutrient-physical functioning networks from the combined data of 4 studies (Nu-Age, ProMuscle, ProMO, and V-Fit, total n = 662, mean ± SD age = 75 ± 7 y). The method was implemented in the R package nutriNetwork which is freely available at https://cran.r-project.org/web/packages/nutriNetwork. Results: Greater intakes of vegetable protein and vitamin B-6 were partially correlated with higher scores on the total Short Physical Performance Battery (SPPB) and the chair rise test. Greater intakes of vitamin B-12 and folate were partially correlated with higher scores on the chair rise test and the total SPPB, respectively. Conclusions: We d
- Published
- 2020
32. A 4-week exercise and protein program improves muscle mass and physical functioning in older adults – A pilot study
- Author
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Grootswagers, Pol, primary, de Regt, Margot, additional, Domić, Jacintha, additional, Dronkers, Jaap, additional, Visser, Marlieke, additional, Witteman, Ben, additional, Hopman, Maria, additional, and Mensink, Marco, additional
- Published
- 2020
- Full Text
- View/download PDF
33. Calcifediol supplementation to reduce pulse pressure in a limited sample of vitamin D deficient older adults with elevated parathyroid hormone levels
- Author
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Grootswagers, Pol, Vaes, Anouk M.M., Tieland, Michael, and de Groot, Lisette C.P.G.M.
- Published
- 2019
- Full Text
- View/download PDF
34. Dietary Intakes of Vegetable Protein, Folate,and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models
- Author
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Behrouzi, Pariya, primary, Grootswagers, Pol, additional, Keizer, Paul L C, additional, Smeets, Ellen T H C, additional, Feskens, Edith J M, additional, de Groot, Lisette C P G M, additional, and van Eeuwijk, Fred A, additional
- Published
- 2020
- Full Text
- View/download PDF
35. Nutritional strategies to improve muscle quality during ageing
- Author
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Grootswagers, Pol, primary
- Full Text
- View/download PDF
36. Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study
- Author
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Claudio Franceschi, Agnes A M Berendsen, Stephan J. L. Bakker, Edith J. M. Feskens, Aurelia Santoro, Corinne Malpuech-Brugère, Lisette C. P. G. M. de Groot, Agata Bialecka-Debek, Ido P. Kema, Nathalie Meunier, Marco Mensink, Susan J. Fairweather-Tait, Amy Jennings, Katarzyna Rolf, Pol Grootswagers, Carolien P J Deen, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Wageningen University and Research [Wageningen] (WUR), University of Groningen [Groningen], University of Bologna/Università di Bologna, Lobachevsky State University of Nizhny Novgorod, Lobachevsky State University [Nizhni Novgorod], Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF), Warsaw University of Life Sciences (SGGW), University of East Anglia [Norwich] (UEA), University of Bologna, University of Nizhny Novgorod, Grootswagers, Pol, Mensink, Marco, Berendsen, Agnes A M, Deen, Carolien P J, Kema, Ido P, Bakker, Stephan J L, Santoro, Aurelia, Franceschi, Claudio, Meunier, Nathalie, Malpuech-Brugère, Corinne, Bialecka-Debek, Agata, Rolf, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Feskens, Edith J M, and de Groot, Lisette C P G M
- Subjects
Male ,Aging ,Homocysteine ,Nutrition and Disease ,muscle ,Medicine (miscellaneous) ,Physiology ,niacin ,AcademicSubjects/MED00160 ,Healthy Aging ,chemistry.chemical_compound ,0302 clinical medicine ,Voeding en Ziekte ,Medicine ,030212 general & internal medicine ,Human Nutrition & Health ,0303 health sciences ,education.field_of_study ,Nutrition and Dietetics ,Hand Strength ,Humane Voeding & Gezondheid ,Physical Functional Performance ,Nutritional Biology ,Europe ,Original Research Communications ,vitamin B-6 ,Quartile ,Female ,Niacin ,Vitamin ,Population ,Nutritional Status ,folate ,03 medical and health sciences ,AcademicSubjects/MED00060 ,physical function ,Humans ,Vitamin B12 ,education ,Exercise ,030304 developmental biology ,Aged ,VLAG ,vitamin B-12 ,Global Nutrition ,Wereldvoeding ,business.industry ,homocysteine ,Physical activity level ,Vitamin B 6 ,Diet ,B vitamins ,chemistry ,Dietary Supplements ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; ABSTRACT Background Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. Objectives The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations. Methods We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n = 1249 healthy older adults (aged 65–79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical performance battery and handgrip dynamometry. Associations were assessed by adjusted linear mixed models. Results Intake of vitamin B-6 was related to lower chair rise test time [β: –0.033 ± 0.016 s (log); P = 0.043]. Vitamin B-6 intake was also significantly associated with handgrip strength, but for this association, a significant interaction effect between vitamin B-6 intake and physical activity level was found. In participants with the lowest level of physical activity, higher intake of vitamin B-6 tended to be associated with greater handgrip strength (β: 1.5 ± 0.8 kg; P = 0.051), whereas in participants in the highest quartile of physical activity, higher intake was associated with lower handgrip strength (β: –1.4 ± 0.7 kg; P = 0.041). No evidence was found for an association between intake of niacin, vitamin B-12, or folate and physical performance or for mediation by niacin status or homocysteine concentrations. Conclusions Vitamin B-6 intake was associated with better chair rise test time in a population of European healthy older adults and also with greater handgrip strength in participants with low physical activity only. Homocysteine concentrations did not mediate these associations. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012.
- Published
- 2021
37. Protein intake and bone mineral density: Cross-sectional relationship and longitudinal effects in older adults.
- Author
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Groenendijk I, Grootswagers P, Santoro A, Franceschi C, Bazzocchi A, Meunier N, Caille A, Malpuech-Brugere C, Bialecka-Debek A, Pietruszka B, Fairweather-Tait S, Jennings A, and de Groot LCPGM
- Subjects
- Animals, Female, Male, Calcium, Absorptiometry, Photon, Plant Proteins pharmacology, Bone Density, Dietary Proteins pharmacology
- Abstract
Background: There are several mechanisms via which increased protein intake might maintain or improve bone mineral density (BMD), but current evidence for an association or effect is inconclusive. The objectives of this study were to investigate the association between dietary protein intake (total, plant and animal) with BMD (spine and total body) and the effects of protein supplementation on BMD., Methods: Individual data from four trials that included either (pre-)frail, undernourished or healthy older adults (aged ≥65 years) were combined. Dietary intake was assessed with food records (2, 3 or 7 days) and BMD with dual-energy X-ray absorptiometry (DXA). Associations and effects were assessed by adjusted linear mixed models., Results: A total of 1570 participants [57% women, median (inter-quartile range): age 71 (68-75) years] for which at least total protein intake and total body BMD were known were included in cross-sectional analyses. In fully adjusted models, total protein intake was associated with higher total body and spine BMD [beta (95% confidence interval): 0.0011 (0.0006-0.0015) and 0.0015 (0.0007-0.0023) g/cm
2 , respectively]. Animal protein intake was associated with higher total body and spine BMD as well [0.0011 (0.0007-0.0016) and 0.0017 (0.0010-0.0024) g/cm2 , respectively]. Plant protein intake was associated with a lower total body and spine BMD [-0.0010 (-0.0020 to -0.0001) and -0.0019 (-0.0034 to -0.0004) g/cm2 , respectively]. Associations were similar between sexes. Participants with a high ratio of animal to plant protein intake had higher BMD. In participants with an adequate calcium intake and sufficient serum 25(OH)D concentrations, the association between total protein intake with total body and spine BMD became stronger. Likewise, the association between animal protein intake with total body BMD was stronger. In the longitudinal analyses, 340 participants [58% women, median (inter-quartile range): age 75 (70-81) years] were included. Interventions of 12 or 24 weeks with protein supplementation or protein supplementation combined with resistance exercise did not lead to significant improvements in BMD., Conclusions: An association between total and animal protein intake with higher BMD was found. In contrast, plant protein intake was associated with lower BMD. Research is warranted to further investigate the added value of dietary protein alongside calcium and vitamin D for BMD improvement, especially in osteopenic or osteoporotic individuals. Moreover, more research on the impact of a plant-based diet on bone health is needed., (© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.)- Published
- 2023
- Full Text
- View/download PDF
38. Dietary Intakes of Vegetable Protein, Folate, and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models.
- Author
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Behrouzi P, Grootswagers P, Keizer PLC, Smeets ETHC, Feskens EJM, de Groot LCPGM, and van Eeuwijk FA
- Subjects
- Aged, Aged, 80 and over, Body Mass Index, Frail Elderly, Humans, Netherlands, Folic Acid administration & dosage, Models, Theoretical, Physical Functional Performance, Plant Proteins, Dietary administration & dosage, Vitamin B 12 administration & dosage, Vitamin B 6 administration & dosage
- Abstract
Background: In nutritional epidemiology, dealing with confounding and complex internutrient relations are major challenges. An often-used approach is dietary pattern analyses, such as principal component analysis, to deal with internutrient correlations, and to more closely resemble the true way nutrients are consumed. However, despite these improvements, these approaches still require subjective decisions in the preselection of food groups. Moreover, they do not make efficient use of multivariate dietary data, because they detect only marginal associations. We propose the use of copula graphical models (CGMs) to model and make statistical inferences regarding complex associations among variables in multivariate data, where associations between all variables can be learned simultaneously., Objective: We aimed to reconstruct nutritional intake and physical functioning networks in Dutch older adults by applying a CGM., Methods: We addressed this issue by uncovering the pairwise associations between variables while correcting for the effect of remaining variables. More specifically, we used a CGM to infer the precision matrix, which contains all the conditional independence relations between nodes in the graph. The nonzero elements of the precision matrix indicate the presence of a direct association. We applied this method to reconstruct nutrient-physical functioning networks from the combined data of 4 studies (Nu-Age, ProMuscle, ProMO, and V-Fit, total n = 662, mean ± SD age = 75 ± 7 y). The method was implemented in the R package nutriNetwork which is freely available at https://cran.r-project.org/web/packages/nutriNetwork., Results: Greater intakes of vegetable protein and vitamin B-6 were partially correlated with higher scores on the total Short Physical Performance Battery (SPPB) and the chair rise test. Greater intakes of vitamin B-12 and folate were partially correlated with higher scores on the chair rise test and the total SPPB, respectively., Conclusions: We determined that vegetable protein, vitamin B-6, folate, and vitamin B-12 intakes are partially correlated with improved functional outcome measurements in Dutch older adults., (Copyright © The Author(s) 2019.)
- Published
- 2020
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