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131 results on '"Groot, Hilde E."'

1. Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Author

Pekayvaz, Kami, Losert, Corinna, Knottenberg, Viktoria, Gold, Christoph, van Blokland, Irene V., Oelen, Roy, Groot, Hilde E., Benjamins, Jan Walter, Brambs, Sophia, Kaiser, Rainer, Gottschlich, Adrian, Hoffmann, Gordon Victor, Eivers, Luke, Martinez-Navarro, Alejandro, Bruns, Nils, Stiller, Susanne, Akgöl, Sezer, Yue, Keyang, Polewka, Vivien, Escaig, Raphael, Joppich, Markus, Janjic, Aleksandar, Popp, Oliver, Kobold, Sebastian, Petzold, Tobias, Zimmer, Ralf, Enard, Wolfgang, Saar, Kathrin, Mertins, Philipp, Huebner, Norbert, van der Harst, Pim, Franke, Lude H., van der Wijst, Monique G. P., Massberg, Steffen, Heinig, Matthias, Nicolai, Leo, and Stark, Konstantin

Published
2024
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7. Single-cell eQTLGen Consortium: a personalized understanding of disease

Author

van der Wijst, Monique G. P., de Vries, Dylan H., Groot, Hilde E., Trynka, Gosia, Hon, Chung-Chau, Nawijn, Martijn C., Idaghdour, Youssef, van der Harst, Pim, Ye, Chun J., Powell, Joseph, Theis, Fabian J., Mahfouz, Ahmed, Heinig, Matthias, and Franke, Lude

Subjects
Quantitative Biology - Genomics, Quantitative Biology - Molecular Networks, Quantitative Biology - Populations and Evolution
Abstract

In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opportunities for mapping eQTLs across different cell types and in dynamic processes, many of which are obscured when using bulk methods. The enormous increase in throughput and reduction in cost per cell now allow this technology to be applied to large-scale population genetics studies. Therefore, we have founded the single-cell eQTLGen consortium (sc-eQTLGen), aimed at pinpointing disease-causing genetic variants and identifying the cellular contexts in which they affect gene expression. Ultimately, this information can enable development of personalized medicine. Here, we outline the goals, approach, potential utility and early proofs-of-concept of the sc-eQTLGen consortium. We also provide a set of study design considerations for future single-cell eQTL studies., Comment: 26 pages, 5 figures, position paper of sc-eQTLGen consortium

Published
2019

10. Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction

Author

Cardiologie, Gezonde Vaten, Circulatory Health, van Blokland, Irene V., Oelen, Roy, Groot, Hilde E., Benjamins, Jan Walter, Pekayvaz, Kami, Losert, Corinna, Knottenberg, Viktoria, Heinig, Matthias, Nicolai, Leo, Stark, Konstantin, van der Harst, Pim, Franke, Lude, van der Wijst, Monique G.P., Cardiologie, Gezonde Vaten, Circulatory Health, van Blokland, Irene V., Oelen, Roy, Groot, Hilde E., Benjamins, Jan Walter, Pekayvaz, Kami, Losert, Corinna, Knottenberg, Viktoria, Heinig, Matthias, Nicolai, Leo, Stark, Konstantin, van der Harst, Pim, Franke, Lude, and van der Wijst, Monique G.P.

Published
2024

11. The gut microbiome across the cardiovascular risk spectrum

Author

Cardiologie, Gezonde Vaten, Circulatory Health, Prins, Femke M., Collij, Valerie, Groot, Hilde E., Björk, Johannes R., Swarte, J. Casper, Andreu-Sánchez, Sergio, Jansen, Bernadien H., Fu, Jingyuan, Harmsen, Hermie J.M., Zhernakova, Alexandra, Lipsic, Erik, Van Der Harst, Pim, Weersma, Rinse K., Gacesa, Ranko, Cardiologie, Gezonde Vaten, Circulatory Health, Prins, Femke M., Collij, Valerie, Groot, Hilde E., Björk, Johannes R., Swarte, J. Casper, Andreu-Sánchez, Sergio, Jansen, Bernadien H., Fu, Jingyuan, Harmsen, Hermie J.M., Zhernakova, Alexandra, Lipsic, Erik, Van Der Harst, Pim, Weersma, Rinse K., and Gacesa, Ranko

Published
2024

12. Association of fibrotic markers with diastolic function after STEMI

Author

Circulatory Health, Gezonde Vaten, Al Ali, Lawien, Meijers, Wouter C., Beldhuis, Iris E., Groot, Hilde E., Lipsic, Erik, van Veldhuisen, Dirk J., Voors, Adriaan A., van der Horst, Iwan C.C., de Boer, Rudolf A., van der Harst, Pim, Circulatory Health, Gezonde Vaten, Al Ali, Lawien, Meijers, Wouter C., Beldhuis, Iris E., Groot, Hilde E., Lipsic, Erik, van Veldhuisen, Dirk J., Voors, Adriaan A., van der Horst, Iwan C.C., de Boer, Rudolf A., and van der Harst, Pim

Published
2024

13. Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Author

Cardiologie, Gezonde Vaten, Circulatory Health, Pekayvaz, Kami, Losert, Corinna, Knottenberg, Viktoria, Gold, Christoph, van Blokland, Irene V., Oelen, Roy, Groot, Hilde E., Benjamins, Jan Walter, Brambs, Sophia, Kaiser, Rainer, Gottschlich, Adrian, Hoffmann, Gordon Victor, Eivers, Luke, Martinez-Navarro, Alejandro, Bruns, Nils, Stiller, Susanne, Akgöl, Sezer, Yue, Keyang, Polewka, Vivien, Escaig, Raphael, Joppich, Markus, Janjic, Aleksandar, Popp, Oliver, Kobold, Sebastian, Petzold, Tobias, Zimmer, Ralf, Enard, Wolfgang, Saar, Kathrin, Mertins, Philipp, Huebner, Norbert, van der Harst, Pim, Franke, Lude H., van der Wijst, Monique G.P., Massberg, Steffen, Heinig, Matthias, Nicolai, Leo, Stark, Konstantin, Cardiologie, Gezonde Vaten, Circulatory Health, Pekayvaz, Kami, Losert, Corinna, Knottenberg, Viktoria, Gold, Christoph, van Blokland, Irene V., Oelen, Roy, Groot, Hilde E., Benjamins, Jan Walter, Brambs, Sophia, Kaiser, Rainer, Gottschlich, Adrian, Hoffmann, Gordon Victor, Eivers, Luke, Martinez-Navarro, Alejandro, Bruns, Nils, Stiller, Susanne, Akgöl, Sezer, Yue, Keyang, Polewka, Vivien, Escaig, Raphael, Joppich, Markus, Janjic, Aleksandar, Popp, Oliver, Kobold, Sebastian, Petzold, Tobias, Zimmer, Ralf, Enard, Wolfgang, Saar, Kathrin, Mertins, Philipp, Huebner, Norbert, van der Harst, Pim, Franke, Lude H., van der Wijst, Monique G.P., Massberg, Steffen, Heinig, Matthias, Nicolai, Leo, and Stark, Konstantin

Published
2024

14. Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST-elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention

Author

Cardiologie, Gezonde Vaten, Circulatory Health, Lenselink, Chris, Ricken, Kim W.L.M., Groot, Hilde E., de Bruijne, Tijs J., Hendriks, Tom, van der Harst, Pim, Voors, Adriaan A., Lipsic, Erik, Cardiologie, Gezonde Vaten, Circulatory Health, Lenselink, Chris, Ricken, Kim W.L.M., Groot, Hilde E., de Bruijne, Tijs J., Hendriks, Tom, van der Harst, Pim, Voors, Adriaan A., and Lipsic, Erik

Published
2024

17. The gut microbiome across the cardiovascular risk spectrum

Author

Prins, Femke M, primary, Collij, Valerie, additional, Groot, Hilde E, additional, Björk, Johannes R, additional, Swarte, J Casper, additional, Andreu-Sánchez, Sergio, additional, Jansen, Bernadien H, additional, Fu, Jingyuan, additional, Harmsen, Hermie J M, additional, Zhernakova, Alexandra, additional, Lipsic, Erik, additional, van der Harst, Pim, additional, Weersma, Rinse K, additional, and Gacesa, Ranko, additional

Published
2023
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18. Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST‐elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention.

Author

Lenselink, Chris, Ricken, Kim W.L.M., Groot, Hilde E., de Bruijne, Tijs J., Hendriks, Tom, van der Harst, Pim, Voors, Adriaan A., and Lipsic, Erik

Subjects
ST elevation myocardial infarction, HEART failure, PERCUTANEOUS coronary intervention, VENTRICULAR ejection fraction, HEART failure patients, LEFT heart atrium
Abstract

Aims: The development and incidence of de‐novo heart failure after ST‐elevation myocardial infarction (STEMI) in the contemporary era of rapid reperfusion are largely unknown. We aimed to establish the incidence of post‐STEMI heart failure, stratified by left ventricular ejection fraction (LVEF) and to find predictors for its occurrence. Furthermore, we investigated the course of left ventricular systolic and diastolic function after STEMI. Methods and results: A total of 1172 all‐comer STEMI patients from the CardioLines Biobank were included. Patients were predominantly male (74.5%) and 64 ± 12 years of age. During a median follow‐up of 3.7 years (2.0, 5.5) we found a total incidence of post‐STEMI heart failure of 10.9%, of which 52.1% heart failure with reduced ejection fraction (HFrEF), 29.4% heart failure with mildly reduced ejection fraction and 18.5% heart failure with preserved ejection fraction (HFpEF). Independent predictors for the development of HFrEF were male sex (β = 0.97, p = 0.009), lung crepitations (β = 1.09, p = 0.001), potassium level (mmol/L, β = 0.43, p = 0.012), neutrophil count (109/L, β = 0.09, p = 0.001) and a reduced LVEF (β = 1.91, p < 0.001) at baseline. Independent predictors for the development of HFpEF were female sex (β = 0.99, p = 0.029), pre‐existing kidney failure (β = 1.95, p = 0.003) and greater left atrial volume index (β = 0.04, p = 0.033) at baseline. Follow‐up echocardiography (median follow‐up 20 months) showed an improvement in LVEF (p < 0.001), whereas changes in diastolic function parameters showed both improvement and deterioration. Conclusion: In the current era of early STEMI reperfusion, still one in 10 patients develops heart failure, with approximately half of the patients with a reduced and half with a mildly reduced or normal LVEF. Predictors for the development of HFrEF were different from HFpEF. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Multi-Omic Factor Analysis uncovers immunological signatures with pathophysiologic and clinical implications in coronary syndromes

Author

Pekayvaz, Kami, primary, Losert, Corinna, additional, Knottenberg, Viktoria, additional, van Blokland, Irene V., additional, Oelen, Roy, additional, Groot, Hilde E., additional, Benjamins, Jan Walter, additional, Brambs, Sophia, additional, Kaiser, Rainer, additional, Eivers, Luke, additional, Polewka, Vivien, additional, Escaig, Raphael, additional, Joppich, Markus, additional, Janjic, Aleksandar, additional, Popp, Oliver, additional, Petzold, Tobias, additional, Zimmer, Ralf, additional, Enard, Wolfgang, additional, Saar, Kathrin, additional, Mertins, Philipp, additional, Huebner, Norbert, additional, van der Harst, Pim, additional, Franke, Lude H., additional, van der Wijst, Monique G. P., additional, Massberg, Steffen, additional, Heinig, Matthias, additional, Nicolai, Leo, additional, and Stark, Konstantin, additional

Published
2023
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26. Predictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction

Author

Gezonde Vaten, Circulatory Health, Al Ali, Lawien, Groot, Hilde E., Assa, Solmaz, Lipsic, Erik, Hummel, Yoran M., van Veldhuisen, Dirk J., Voors, Adriaan A., van der Horst, Iwan C.C., Lam, Carolyn S., van der Harst, Pim, Gezonde Vaten, Circulatory Health, Al Ali, Lawien, Groot, Hilde E., Assa, Solmaz, Lipsic, Erik, Hummel, Yoran M., van Veldhuisen, Dirk J., Voors, Adriaan A., van der Horst, Iwan C.C., Lam, Carolyn S., and van der Harst, Pim

Published
2023

27. Additional file 1 of Predictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction

Author

Al Ali, Lawien, Groot, Hilde E., Assa, Solmaz, Lipsic, Erik, Hummel, Yoran M., van Veldhuisen, Dirk J., Voors, Adriaan A., van der Horst, Iwan C. C., Lam, Carolyn S., and van der Harst, Pim

Abstract

Additional files 1: Table S1. Discharge medication of all patients, and stratified by E/e′ below and above median at 4 months after STEMI. E/e′: ratio of transmitral flow velocity (E) to early mitral annulus velocity (e′).

Published
2023
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28. Additional file 16 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

Author

Li, Shuang, Schmid, Katharina T., de Vries, Dylan H., Korshevniuk, Maryna, Losert, Corinna, Oelen, Roy, van Blokland, Irene V., Groot, Hilde E., Swertz, Morris A., van der Harst, Pim, Westra, Harm-Jan, van der Wijst, Monique G.P., Heinig, Matthias, and Franke, Lude

Abstract

Additional file 16. Review history.

Published
2023
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29. Additional file 2 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

Author

Li, Shuang, Schmid, Katharina T., de Vries, Dylan H., Korshevniuk, Maryna, Losert, Corinna, Oelen, Roy, van Blokland, Irene V., Groot, Hilde E., Swertz, Morris A., van der Harst, Pim, Westra, Harm-Jan, van der Wijst, Monique G.P., Heinig, Matthias, and Franke, Lude

Abstract

Additional file 2: Supplementary Figures. Collection of all Fig. S1-34.

Published
2023
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30. Additional file 3 of Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

Author

Li, Shuang, Schmid, Katharina T., de Vries, Dylan H., Korshevniuk, Maryna, Losert, Corinna, Oelen, Roy, van Blokland, Irene V., Groot, Hilde E., Swertz, Morris A., van der Harst, Pim, Westra, Harm-Jan, van der Wijst, Monique G.P., Heinig, Matthias, and Franke, Lude

Abstract

Additional file 3: Supplementary Note. More extensive description of meta-cell evaluation, alternative GRN construction methods and interpretation of additional co-eQTL examples.

Published
2023
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31. Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Author

Gürgöze, Muhammed T., Kardys, Isabella, Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., Groot, Hilde E., van der Harst, Pim, Umans, Victor A., Kietselaer, Bas, Ronner, Eelko, Lenderink, Timo, Asselbergs, Folkert W., Manintveld, Olivier C., Boersma, Eric, Gürgöze, Muhammed T., Kardys, Isabella, Akkerhuis, K. Martijn, Oemrawsingh, Rohit M., Groot, Hilde E., van der Harst, Pim, Umans, Victor A., Kietselaer, Bas, Ronner, Eelko, Lenderink, Timo, Asselbergs, Folkert W., Manintveld, Olivier C., and Boersma, Eric

Abstract

Iron deficiency has been extensively researched and is associated with adverse outcomes in heart failure. However, to our knowledge, the temporal evolution of iron status has not been previously investigated in patients with acute coronary syndrome (ACS). Therefore, we aimed to explore the temporal pattern of repeatedly measured iron, ferritin, transferrin, and transferrin saturation (TSAT) in relation to prognosis post-ACS. BIOMArCS (BIOMarker study to identify the Acute risk of a Coronary Syndrome) is a prospective, multicenter, observational cohort study conducted in The Netherlands between 2008 and 2015. A total of 844 patients with post-ACS were enrolled and underwent high-frequency (median 17) blood sampling during 1 year follow-up. Biomarkers of iron status were measured batchwise in a central laboratory. We analyzed 3 patient subsets, including the case-cohort (n = 187). The primary endpoint (PE) was a composite of cardiovascular mortality and repeat nonfatal ACS, including unstable angina pectoris requiring revascularization. The association between iron status and the PE was analyzed using multivariable joint models. Mean age was 63 years; 78% were men, and >50% had iron deficiency at first sample in the case-cohort. After adjustment for a broad range of clinical variables, 1 SD decrease in log-iron was associated with a 2.2-fold greater risk of the PE (hazard ratio 2.19, 95% confidence interval 1.34 to 3.54, p = 0.002). Similarly, 1 SD decrease in log-TSAT was associated with a 78% increased risk of the PE (hazard ratio 1.78, 95% confidence interval 1.17 to 2.65, p = 0.006). Ferritin and transferrin were not associated with the PE. Repeated measurements of iron and TSAT predict risk of adverse outcomes in patients with post-ACS during 1 year follow-up. Trial Registration: The Netherlands Trial Register. Unique identifiers: NTR1698 and NTR1106. Registered at https://www.trialregister.nl/trial/1614 and https://www.trialregister.nl/trial/1073.

Published
2022

34. Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Author

Team Medisch, Circulatory Health, Gürgöze, Muhammed T, Kardys, Isabella, Akkerhuis, K Martijn, Oemrawsingh, Rohit M, Groot, Hilde E, van der Harst, Pim, Umans, Victor A, Kietselaer, Bas, Ronner, Eelko, Lenderink, Timo, Asselbergs, Folkert W, Manintveld, Olivier C, Boersma, Eric, Team Medisch, Circulatory Health, Gürgöze, Muhammed T, Kardys, Isabella, Akkerhuis, K Martijn, Oemrawsingh, Rohit M, Groot, Hilde E, van der Harst, Pim, Umans, Victor A, Kietselaer, Bas, Ronner, Eelko, Lenderink, Timo, Asselbergs, Folkert W, Manintveld, Olivier C, and Boersma, Eric

Published
2022

35. Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity: A cross sectional study in the population-based LifeLines DEEP cohort

Author

Team Medisch, Circulatory Health, Groenen, Anouk G, Bazioti, Venetia, van Zeventer, Isabelle A, Chen, Lianmin, Groot, Hilde E, Balder, Jan-Willem, Zhernakova, Alexandra, van der Harst, Pim, Rimbert, Antoine, Kuivenhoven, Jan Albert, Fu, Jingyuan, Westerterp, Marit, Team Medisch, Circulatory Health, Groenen, Anouk G, Bazioti, Venetia, van Zeventer, Isabelle A, Chen, Lianmin, Groot, Hilde E, Balder, Jan-Willem, Zhernakova, Alexandra, van der Harst, Pim, Rimbert, Antoine, Kuivenhoven, Jan Albert, Fu, Jingyuan, and Westerterp, Marit

Published
2022

36. Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Author

Gürgöze, Muhammed T., primary, Kardys, Isabella, additional, Akkerhuis, K. Martijn, additional, Oemrawsingh, Rohit M., additional, Groot, Hilde E., additional, van der Harst, Pim, additional, Umans, Victor A., additional, Kietselaer, Bas, additional, Ronner, Eelko, additional, Lenderink, Timo, additional, Asselbergs, Folkert W., additional, Manintveld, Olivier C., additional, and Boersma, Eric, additional

Published
2022
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43. Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment

Author

Team Medisch, Circulatory Health, Wang, Siqi, Said, M Abdullah, Groot, Hilde E, van der Most, Peter J, Thio, Chris H L, van de Vegte, Yordi J, Verweij, Niek, Snieder, Harold, van der Harst, Pim, Team Medisch, Circulatory Health, Wang, Siqi, Said, M Abdullah, Groot, Hilde E, van der Most, Peter J, Thio, Chris H L, van de Vegte, Yordi J, Verweij, Niek, Snieder, Harold, and van der Harst, Pim

Published
2021

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