480 results on '"Groop, Leif C."'
Search Results
2. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
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van Zuydam, Natalie R, Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R, McKeigue, Paul M, Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Robert P, Salem, Rany M, Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M, Jiang, Guozhi, Tam, Claudia HT, Luk, Andrea OY, Lee, Heung Man, Lim, Cadmon KP, Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana CN, Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, McKnight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G, Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Linda T, Ahluwalia, Tarunveer S, Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R, Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D, Tregouet, David, Maxwell, Alexander P, Lim, Su Chi, Ma, Ronald CW, Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C, Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin NA, Groop, Per-Henrik, Colhoun, Helen M, Groop, Leif C, McCarthy, Mark I, Koivula, S, Uggeldahl, T, Forslund, T, Halonen, A, Koistinen, A, Koskiaho, P, Laukkanen, M, Saltevo, J, Tiihonen, M, Forsen, M, Granlund, H, Jonsson, A-C, Nyroos, B, Kinnunen, P, Orvola, A, Salonen, T, Vähänen, A, Paldanius, Kotka R, and Riihelä, M
- Subjects
Diabetes ,Genetics ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Good Health and Well Being ,Adult ,Aged ,Aged ,80 and over ,Case-Control Studies ,Diabetes Mellitus ,Type 2 ,Diabetic Nephropathies ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,Renal Insufficiency ,Chronic ,Finnish Diabetic Nephropathy Study ,Hong Kong Diabetes Registry Theme-based Research Scheme Project Group ,Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group ,GENIE (GEnetics of Nephropathy an International Effort) Consortium ,Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group ,SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium ,Medical and Health Sciences ,Endocrinology & Metabolism - Abstract
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 × 10-8) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.
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- 2018
3. Relationship between insulin sensitivity and gene expression in human skeletal muscle
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Parikh, Hemang M., Elgzyri, Targ, Alibegovic, Amra, Hiscock, Natalie, Ekström, Ola, Eriksson, Karl-Fredrik, Vaag, Allan, Groop, Leif C., Ström, Kristoffer, and Hansson, Ola
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- 2021
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4. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
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Mahajan, Anubha, Go, Min Jin, Zhang, Weihua, Below, Jennifer E, Gaulton, Kyle J, Ferreira, Teresa, Horikoshi, Momoko, Johnson, Andrew D, Ng, Maggie CY, Prokopenko, Inga, Saleheen, Danish, Wang, Xu, Zeggini, Eleftheria, Abecasis, Goncalo R, Adair, Linda S, Almgren, Peter, Atalay, Mustafa, Aung, Tin, Baldassarre, Damiano, Balkau, Beverley, Bao, Yuqian, Barnett, Anthony H, Barroso, Ines, Basit, Abdul, Been, Latonya F, Beilby, John, Bell, Graeme I, Benediktsson, Rafn, Bergman, Richard N, Boehm, Bernhard O, Boerwinkle, Eric, Bonnycastle, Lori L, Burtt, Noël, Cai, Qiuyin, Campbell, Harry, Carey, Jason, Cauchi, Stephane, Caulfield, Mark, Chan, Juliana CN, Chang, Li-Ching, Chang, Tien-Jyun, Chang, Yi-Cheng, Charpentier, Guillaume, Chen, Chien-Hsiun, Chen, Han, Chen, Yuan-Tsong, Chia, Kee-Seng, Chidambaram, Manickam, Chines, Peter S, Cho, Nam H, Cho, Young Min, Chuang, Lee-Ming, Collins, Francis S, Cornelis, Marilyn C, Couper, David J, Crenshaw, Andrew T, van Dam, Rob M, Danesh, John, Das, Debashish, de Faire, Ulf, Dedoussis, George, Deloukas, Panos, Dimas, Antigone S, Dina, Christian, Doney, Alex SF, Donnelly, Peter J, Dorkhan, Mozhgan, van Duijn, Cornelia, Dupuis, Josée, Edkins, Sarah, Elliott, Paul, Emilsson, Valur, Erbel, Raimund, Eriksson, Johan G, Escobedo, Jorge, Esko, Tonu, Eury, Elodie, Florez, Jose C, Fontanillas, Pierre, Forouhi, Nita G, Forsen, Tom, Fox, Caroline, Fraser, Ross M, Frayling, Timothy M, Froguel, Philippe, Frossard, Philippe, Gao, Yutang, Gertow, Karl, Gieger, Christian, Gigante, Bruna, Grallert, Harald, Grant, George B, Groop, Leif C, Groves, Christopher J, Grundberg, Elin, Guiducci, Candace, Hamsten, Anders, Han, Bok-Ghee, Hara, Kazuo, and Hassanali, Neelam
- Subjects
Biological Sciences ,Genetics ,Human Genome ,Diabetes ,Metabolic and endocrine ,Alleles ,Asian People ,Case-Control Studies ,Diabetes Mellitus ,Type 2 ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Hispanic or Latino ,Humans ,Polymorphism ,Single Nucleotide ,Risk Factors ,White People ,DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium ,Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium ,South Asian Type 2 Diabetes (SAT2D) Consortium ,Mexican American Type 2 Diabetes (MAT2D) Consortium ,Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
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- 2014
5. Correction to: A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY
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Kettunen, Jarno L. T., Rantala, Elina, Dwivedi, Om P., Isomaa, Bo, Sarelin, Leena, Kokko, Paula, Hakaste, Liisa, Miettinen, Päivi J., Groop, Leif C., and Tuomi, Tiinamaija
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- 2022
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6. Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies
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Quell, Jan D., Römisch-Margl, Werner, Colombo, Marco, Krumsiek, Jan, Evans, Anne M., Mohney, Robert, Salomaa, Veikko, de Faire, Ulf, Groop, Leif C., Agakov, Felix, Looker, Helen C., McKeigue, Paul, Colhoun, Helen M., and Kastenmüller, Gabi
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- 2017
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7. Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
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Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, and Wareham, Nicholas J.
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- 2020
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8. Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
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Lee, Yunsung, Haftorn, Kristine L., Denault, William R. P., Nustad, Haakon E., Page, Christian M., Lyle, Robert, Lee-Ødegård, Sindre, Moen, Gunn-Helen, Prasad, Rashmi B., Groop, Leif C., Sletner, Line, Sommer, Christine, Magnus, Maria C., Gjessing, Håkon K., Harris, Jennifer R., Magnus, Per, Håberg, Siri E., Jugessur, Astanand, and Bohlin, Jon
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- 2020
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9. Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
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Heni, Martin, Kullmann, Stephanie, Ahlqvist, Emma, Wagner, Robert, Machicao, Fausto, Staiger, Harald, Häring, Hans-Ulrich, Almgren, Peter, Groop, Leif C., Small, Dana M., Fritsche, Andreas, and Preissl, Hubert
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- 2016
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10. Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
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Hindy, George, primary, Dornbos, Peter, additional, Chaffin, Mark D., additional, Liu, Dajiang J., additional, Wang, Minxian, additional, Selvaraj, Margaret Sunitha, additional, Zhang, David, additional, Park, Joseph, additional, Aguilar-Salinas, Carlos A., additional, Antonacci-Fulton, Lucinda, additional, Ardissino, Diego, additional, Arnett, Donna K., additional, Aslibekyan, Stella, additional, Atzmon, Gil, additional, Ballantyne, Christie M., additional, Barajas-Olmos, Francisco, additional, Barzilai, Nir, additional, Becker, Lewis C., additional, Bielak, Lawrence F., additional, Bis, Joshua C., additional, Blangero, John, additional, Boerwinkle, Eric, additional, Bonnycastle, Lori L., additional, Bottinger, Erwin, additional, Bowden, Donald W., additional, Bown, Matthew J., additional, Brody, Jennifer A., additional, Broome, Jai G., additional, Burtt, Noël P., additional, Cade, Brian E., additional, Centeno-Cruz, Federico, additional, Chan, Edmund, additional, Chang, Yi-Cheng, additional, Chen, Yii-Der I., additional, Cheng, Ching-Yu, additional, Choi, Won Jung, additional, Chowdhury, Rajiv, additional, Contreras-Cubas, Cecilia, additional, Córdova, Emilio J., additional, Correa, Adolfo, additional, Cupples, L. Adrienne, additional, Curran, Joanne E., additional, Danesh, John, additional, de Vries, Paul S., additional, DeFronzo, Ralph A., additional, Doddapaneni, Harsha, additional, Duggirala, Ravindranath, additional, Dutcher, Susan K., additional, Ellinor, Patrick T., additional, Emery, Leslie S., additional, Florez, Jose C., additional, Fornage, Myriam, additional, Freedman, Barry I., additional, Fuster, Valentin, additional, Garay-Sevilla, Ma. Eugenia, additional, García-Ortiz, Humberto, additional, Germer, Soren, additional, Gibbs, Richard A., additional, Gieger, Christian, additional, Glaser, Benjamin, additional, Gonzalez, Clicerio, additional, Gonzalez-Villalpando, Maria Elena, additional, Graff, Mariaelisa, additional, Graham, Sarah E., additional, Grarup, Niels, additional, Groop, Leif C., additional, Guo, Xiuqing, additional, Gupta, Namrata, additional, Han, Sohee, additional, Hanis, Craig L., additional, Hansen, Torben, additional, He, Jiang, additional, Heard-Costa, Nancy L., additional, Hung, Yi-Jen, additional, Hwang, Mi Yeong, additional, Irvin, Marguerite R., additional, Islas-Andrade, Sergio, additional, Jarvik, Gail P., additional, Kang, Hyun Min, additional, Kardia, Sharon L.R., additional, Kelly, Tanika, additional, Kenny, Eimear E., additional, Khan, Alyna T., additional, Kim, Bong-Jo, additional, Kim, Ryan W., additional, Kim, Young Jin, additional, Koistinen, Heikki A., additional, Kooperberg, Charles, additional, Kuusisto, Johanna, additional, Kwak, Soo Heon, additional, Laakso, Markku, additional, Lange, Leslie A., additional, Lee, Jiwon, additional, Lee, Juyoung, additional, Lee, Seonwook, additional, Lehman, Donna M., additional, Lemaitre, Rozenn N., additional, Linneberg, Allan, additional, Liu, Jianjun, additional, Loos, Ruth J.F., additional, Lubitz, Steven A., additional, Lyssenko, Valeriya, additional, Ma, Ronald C.W., additional, Martin, Lisa Warsinger, additional, Martínez-Hernández, Angélica, additional, Mathias, Rasika A., additional, McGarvey, Stephen T., additional, McPherson, Ruth, additional, Meigs, James B., additional, Meitinger, Thomas, additional, Melander, Olle, additional, Mendoza-Caamal, Elvia, additional, Metcalf, Ginger A., additional, Mi, Xuenan, additional, Mohlke, Karen L., additional, Montasser, May E., additional, Moon, Jee-Young, additional, Moreno-Macías, Hortensia, additional, Morrison, Alanna C., additional, Muzny, Donna M., additional, Nelson, Sarah C., additional, Nilsson, Peter M., additional, O’Connell, Jeffrey R., additional, Orho-Melander, Marju, additional, Orozco, Lorena, additional, Palmer, Colin N.A., additional, Palmer, Nicholette D., additional, Park, Cheol Joo, additional, Park, Kyong Soo, additional, Pedersen, Oluf, additional, Peralta, Juan M., additional, Peyser, Patricia A., additional, Post, Wendy S., additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Qi, Qibin, additional, Rao, D.C., additional, Redline, Susan, additional, Reiner, Alexander P., additional, Revilla-Monsalve, Cristina, additional, Rich, Stephen S., additional, Samani, Nilesh, additional, Schunkert, Heribert, additional, Schurmann, Claudia, additional, Seo, Daekwan, additional, Seo, Jeong-Sun, additional, Sim, Xueling, additional, Sladek, Rob, additional, Small, Kerrin S., additional, So, Wing Yee, additional, Stilp, Adrienne M., additional, Tai, E. Shyong, additional, Tam, Claudia H.T., additional, Taylor, Kent D., additional, Teo, Yik Ying, additional, Thameem, Farook, additional, Tomlinson, Brian, additional, Tsai, Michael Y., additional, Tuomi, Tiinamaija, additional, Tuomilehto, Jaakko, additional, Tusié-Luna, Teresa, additional, Udler, Miriam S., additional, van Dam, Rob M., additional, Vasan, Ramachandran S., additional, Viaud Martinez, Karine A., additional, Wang, Fei Fei, additional, Wang, Xuzhi, additional, Watkins, Hugh, additional, Weeks, Daniel E., additional, Wilson, James G., additional, Witte, Daniel R., additional, Wong, Tien-Yin, additional, Yanek, Lisa R., additional, Kathiresan, Sekar, additional, Rader, Daniel J., additional, Rotter, Jerome I., additional, Boehnke, Michael, additional, McCarthy, Mark I., additional, Willer, Cristen J., additional, Natarajan, Pradeep, additional, Flannick, Jason A., additional, Khera, Amit V., additional, and Peloso, Gina M., additional
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- 2022
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11. A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY
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Kettunen, Jarno L. T., primary, Rantala, Elina, additional, Dwivedi, Om P., additional, Isomaa, Bo, additional, Sarelin, Leena, additional, Kokko, Paula, additional, Hakaste, Liisa, additional, Miettinen, Päivi J., additional, Groop, Leif C., additional, and Tuomi, Tiinamaija, additional
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- 2021
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12. Polymorphisms of the HDL Receptor Gene Associated with HDL Cholesterol Levels in Diabetic Kindred from Three Populations
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McCarthy, Jeanette J., Lewitzky, Steve, Reeves, Cynthia, Permutt, Alan, Glaser, Benjamin, Groop, Leif C., Lehner, Thomas, and Meyer, Joanne M.
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- 2003
13. The genetics of diabetic complications
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Ahlqvist, Emma, van Zuydam, Natalie R., Groop, Leif C., and McCarthy, Mark I.
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- 2015
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14. Genetic studies of body mass index yield new insights for obesity biology
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Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jianʼan, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E., de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Jörgen, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Quinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Sin Lo, Ken, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Vernon Smith, Albert, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, vanʼt Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Adrienne Cupples, L., Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Kees Hovingh, G., Humphries, Steve E., Hunt, Steven C., Hyppönen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Wouter Jukema, J., Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Carola Zillikens, M., Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stéphane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., OʼConnell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Abecasis, Gonçalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, André, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Inês, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., and Speliotes, Elizabeth K.
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- 2015
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15. New genetic loci link adipose and insulin biology to body fat distribution
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Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jianʼan, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., OʼConnell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, Adrienne L., Morris, Andrew P., Lindgren, Cecilia M., and Mohlke, Karen L
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- 2015
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16. Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
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Scott, Robert A., Fall, Tove, Pasko, Dorota, Barker, Adam, Sharp, Stephen J., Arriola, Larraitz, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Boeing, Heiner, Clavel-Chapelon, Françoise, Crowe, Francesca L., Dekker, Jacqueline M., Fagherazzi, Guy, Ferrannini, Ele, Forouhi, Nita G., Franks, Paul W., Gavrila, Diana, Giedraitis, Vilmantas, Grioni, Sara, Groop, Leif C., Kaaks, Rudolf, Key, Timothy J., Kühn, Tilman, Lotta, Luca A., Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sala, Núria, Sánchez, María-José, Schulze, Matthias B., Siddiq, Afshan, Slimani, Nadia, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L., Yaghootkar, Hanieh, McCarthy, Mark I., Semple, Robert K., Riboli, Elio, Walker, Mark, Ingelsson, Erik, Frayling, Tim M., Savage, David B., Langenberg, Claudia, and Wareham, Nicholas J.
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- 2014
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17. Cohort profile: Epigenetics in Pregnancy (EPIPREG) – population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes
- Author
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Fragoso-Bargas, Nicolas, primary, Opsahl, Julia O., additional, Kiryushchenko, Nadezhda, additional, Böttcher, Yvonne, additional, Lee-Ødegård, Sindre, additional, Qvigstad, Elisabeth, additional, Richardsen, Kåre Rønn, additional, Waage, Christin W., additional, Sletner, Line, additional, Jenum, Anne Karen, additional, Prasad, Rashmi B., additional, Groop, Leif C., additional, Moen, Gunn-Helen, additional, Birkeland, Kåre I., additional, and Sommer, Christine, additional
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- 2021
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18. Additional file 1 of Relationship between insulin sensitivity and gene expression in human skeletal muscle
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Parikh, Hemang M., Targ Elgzyri, Alibegovic, Amra, Hiscock, Natalie, Ekström, Ola, Karl-Fredrik Eriksson, Vaag, Allan, Groop, Leif C., Ström, Kristoffer, and Hansson, Ola
- Abstract
Additional file 1: Supplementary Table S1. Clinical and biochemical characteristics of male subjects from study A. Supplementary Table S2. Clinical and biochemical characteristics of male subjects from study B. Supplementary Table S3. Genes of which expression levels in skeletal muscle were positively correlated with insulin sensitivity (1/HOMA-IR) in study A. Supplementary Table S4. Genes of which expression levels in skeletal muscle were inversely correlated with insulin sensitivity (1/HOMA-IR) in study A. Supplementary Table S5. Significantly enriched Gene Ontology (GO) categories in the 70 genes whose expression level in skeletal muscle positively correlated with insulin sensitivity in Study A, analyzed with the WEB-based GEne SeT AnaLysis Toolkit (WebGestalt). Supplementary Table S6. Significantly enriched Wikipathways, in the 70 genes whose expression level in skeletal muscle positively correlated with insulin sensitivity in Study A, analyzed with the WEB-based GEne SeT AnaLysis Toolkit (WebGestalt). Supplementary Table S7. Significantly enriched Gene Ontology (GO) categories in the 110 genes whose expression level in skeletal muscle was inversely correlated with insulin sensitivity in Study A, analyzed with the WEB-based GEne SeT AnaLysis Toolkit (WebGestalt).
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- 2021
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19. Molecular correlates for maximal oxygen uptake and type 1 fibers
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Parikh, Hemang, Nilsson, Emma, Ling, Charlotte, Poulsen, Pernille, Almgren, Peter, Nittby, Henrietta, Eriksson, Karl-Fredrik, Vaag, Allan, and Groop, Leif C.
- Subjects
Oxidative phosphorylation -- Observations ,Aging -- Influence ,Gene expression -- Research ,Exercise -- Physiological aspects ,Exercise -- Research ,Biological sciences - Abstract
Maximal oxygen uptake (V[O.sub.2max]) and the amount of type 1 fibers are interrelated, but the underlying unifying molecular mechanisms are poorly understood. To explore these mechanisms, we related gene expression profiles in skeletal muscle biopsies of 43 age-matched men from published datasets with V[O.sub.2max] and the amount of type 1 fibers and replicated some of the findings in muscle biopsies from 154 young and elderly individuals using real-time PCR. We identified 66 probe sets (genes or expressed sequence tags) positively and 83 probe sets inversely correlated with V[O.sub.2max] and 171 probe sets positively and 217 probe sets inversely correlated with percentage of type 1 fibers in human skeletal muscle. Genes involved in oxidative phosphorylation (OXPHOS) showed high expression in individuals with high V[O.sub.2max], whereas the opposite was not the case in individuals with low V[O.sub.2max]. Instead, genes such as AHNAK and BCL6 were associated with low V[O.sub.2max]. Also, expression of the OXPHOS genes NDUFB5 and ATP5C1 increased with exercise training and decreased with aging. In contrast, expression of AHNAK in skeletal muscle decreased with exercise training and increased with aging. Eleven genes (NDUFB4, COX5A, UQCRB, ATP5C1, ATP5G3, ETHE1, FABP3, ISCA1, MYST4, C9orf3, and PKIA) were positively correlated with both V[O.sub.2max] and the percentage of type 1 fibers. V[O.sub.2max] closely reflects expression of OXPHOS genes, particularly that of NDUFB5 and ATP5C1, in skeletal muscle, suggesting good muscle fitness. In contrast, a high expression of AHNAK was associated with a low V[O.sub.2max] and poor muscle fitness. aging; AHNAK; oxidative phosphorylation; exercise
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- 2008
20. Additional file 3 of Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
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Lee, Yunsung, Haftorn, Kristine L., Denault, William R. P., Nustad, Haakon E., Page, Christian M., Lyle, Robert, Lee-Ødegård, Sindre, Gunn-Helen Moen, Prasad, Rashmi B., Groop, Leif C., Sletner, Line, Sommer, Christine, Magnus, Maria C., Gjessing, Håkon K., Harris, Jennifer R., Magnus, Per, Håberg, Siri E., Astanand Jugessur, and Bohlin, Jon
- Abstract
Additional file 3. This file includes 1) further details (sample selection, DNA extraction, and quality control) of EPIPREG, 2) cross-validation curves of mean squared error over lambda and alpha values for eABEC, 3) determination of the reduced sample sizes for Fig. 4, and 4) further information regarding batch adjustment in developing the ABECs.
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- 2020
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21. Additional file 2 of Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
- Author
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Lee, Yunsung, Haftorn, Kristine L., Denault, William R. P., Nustad, Haakon E., Page, Christian M., Lyle, Robert, Lee-Ødegård, Sindre, Gunn-Helen Moen, Prasad, Rashmi B., Groop, Leif C., Sletner, Line, Sommer, Christine, Magnus, Maria C., Gjessing, Håkon K., Harris, Jennifer R., Magnus, Per, Håberg, Siri E., Astanand Jugessur, and Bohlin, Jon
- Abstract
Additional file 2. This file includes 1) a figure displaying the age prediction of cABEC, 2) a table containing the bootstrapped 95% confidence intervals for the r values in Figs. 4, 5 and 6) figures displaying the age prediction of the ABECs and the other published clocks in EPIPREG and GSE132203, 4) a figure illustrating the regression-to-the-mean effect and 5) histograms displaying the age distribution of individuals in each cohort.
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- 2020
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22. TXNIP regulates peripheral glucose metabolism in humans
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Parikh, Hemang, Carlsson, Emma, Chutkow, William A., Johansson, Lovisa E., Storgaard, Heidi, Poulsen, Pernille, Saxena, Richa, Ladd, Christine, Schulze, P. Christian, Mazzini, Michael J., Jensen, Christine Bjorn, Krook, Anna, Bjornholm, Marie, Tornqvist, Hans, Zierath, Juleen R., Ridderstrale, Martin, Altshuler, David, Lee, Richard T., Vaag, Allan, Groop, Leif C., and Mootha, Vamsi K.
- Subjects
Gene expression -- Observations ,Glucose metabolism -- Health aspects ,Proteins -- Health aspects ,Medical research ,Medicine, Experimental - Abstract
ABSTRACT Background Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest [...]
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- 2007
23. 5’ flanking variants of resistin are associated with obesity
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Engert, James C., Gaudet, Daniel, Vohl, Marie-Claude, Williams, Scott M., Després, Jean-Pierre, Lepage, Pierre, Loredo-Osti, J. Concepción, Faith, Janet, Doré, Carole, Renaud, Yannick, Burtt, Noël P., Villeneuve, Amélie, Hirschhorn, Joel N., Altshuler, David, Groop, Leif C., Hudson, Thomas J., Engert, James C., Gaudet, Daniel, Vohl, Marie-Claude, Williams, Scott M., Després, Jean-Pierre, Lepage, Pierre, Loredo-Osti, J. Concepción, Faith, Janet, Doré, Carole, Renaud, Yannick, Burtt, Noël P., Villeneuve, Amélie, Hirschhorn, Joel N., Altshuler, David, Groop, Leif C., and Hudson, Thomas J.
- Abstract
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine singlenucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5 flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency 0.04) was significantly associated with an increase in BMI (P 0.03 and P 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% CI 1.28–5.81) and the g.-420 variants (1.58, 1.06–2.35) were associated with an increased risk for a BMI >30 kg/m2. In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.
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- 2020
24. Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
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Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, Wareham, Nicholas J., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, and Wareham, Nicholas J.
- Published
- 2020
25. Cohort Profile: Epigenetics in Pregnancy (EPIPREG) – population-based sample of European and South Asian pregnant women living in Norway with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes
- Author
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Fragoso-Bargas, Nicolas, primary, Opsahl, Julia O., additional, Kiryushchenko, Nadezhda, additional, Böttcher, Yvonne, additional, Lee-Ødegård, Sindre, additional, Qvigstad, Elisabeth, additional, Richardsen, Kåre Rønn, additional, Waage, Christin W., additional, Sletner, Line, additional, Jenum, Anne Karen, additional, Prasad, Rashmi B., additional, Groop, Leif C., additional, Moen, Gunn-Helen, additional, Birkeland, Kåre I., additional, and Sommer, Christine, additional
- Published
- 2021
- Full Text
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26. Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk: Results from the EPIC-InterAct study
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Brand, Judith S., van der Schouw, Yvonne T., Onland-Moret, N. Charlotte, Sharp, Stephen J., Ong, Ken K., Khaw, Kay-Tee, Ardanaz, Eva, Amiano, Pilar, Boeing, Heiner, Chirlaque, Maria-Dolores, Clavel-Chapelon, Françoise, Crowe, Francesca L., de Lauzon-Guillain, Blandine, Duell, Eric J., Fagherazzi, Guy, Franks, Paul W., Grioni, Sara, Groop, Leif C., Kaaks, Rudolf, Key, Timothy J., Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Sánchez, María-José, Slimani, Nadia, Teucher, Birgit, Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L., Feskens, Edith J.M., Langenberg, Claudia, Forouhi, Nita G., Riboli, Elio, and Wareham, Nicholas J.
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- 2013
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27. Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
- Author
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Travers, Mary E., Mackay, Deborah J.G., Dekker Nitert, Marloes, Morris, Andrew P., Lindgren, Cecilia M., Berry, Andrew, Johnson, Paul R., Hanley, Neil, Groop, Leif C., McCarthy, Mark I., and Gloyn, Anna L.
- Published
- 2013
- Full Text
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28. FTO genotype is associated with phenotypic variability of body mass index
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Yang, Jian, Loos, Ruth J. F., Powell, Joseph E., Medland, Sarah E., Speliotes, Elizabeth K., Chasman, Daniel I., Rose, Lynda M., Thorleifsson, Gudmar, Steinthorsdottir, Valgerdur, Mägi, Reedik, Waite, Lindsay, Vernon Smith, Albert, Yerges-Armstrong, Laura M., Monda, Keri L., Hadley, David, Mahajan, Anubha, Li, Guo, Kapur, Karen, Vitart, Veronique, Huffman, Jennifer E., Wang, Sophie R., Palmer, Cameron, Esko, Tõnu, Fischer, Krista, Hua Zhao, Jing, Demirkan, Ayşe, Isaacs, Aaron, Feitosa, Mary F., Luan, Jian’an, Heard-Costa, Nancy L., White, Charles, Jackson, Anne U., Preuss, Michael, Ziegler, Andreas, Eriksson, Joel, Kutalik, Zoltán, Frau, Francesca, Nolte, Ilja M., Van Vliet-Ostaptchouk, Jana V., Hottenga, Jouke-Jan, Jacobs, Kevin B., Verweij, Niek, Goel, Anuj, Medina-Gomez, Carolina, Estrada, Karol, Lynn Bragg-Gresham, Jennifer, Sanna, Serena, Sidore, Carlo, Tyrer, Jonathan, Teumer, Alexander, Prokopenko, Inga, Mangino, Massimo, Lindgren, Cecilia M., Assimes, Themistocles L., Shuldiner, Alan R., Hui, Jennie, Beilby, John P., McArdle, Wendy L., Hall, Per, Haritunians, Talin, Zgaga, Lina, Kolcic, Ivana, Polasek, Ozren, Zemunik, Tatijana, Oostra, Ben A., Juhani Junttila, M., Grönberg, Henrik, Schreiber, Stefan, Peters, Annette, Hicks, Andrew A., Stephens, Jonathan, Foad, Nicola S., Laitinen, Jaana, Pouta, Anneli, Kaakinen, Marika, Willemsen, Gonneke, Vink, Jacqueline M., Wild, Sarah H., Navis, Gerjan, Asselbergs, Folkert W., Homuth, Georg, John, Ulrich, Iribarren, Carlos, Harris, Tamara, Launer, Lenore, Gudnason, Vilmundur, O’Connell, Jeffrey R., Boerwinkle, Eric, Cadby, Gemma, Palmer, Lyle J., James, Alan L., Musk, Arthur W., Ingelsson, Erik, Psaty, Bruce M., Beckmann, Jacques S., Waeber, Gerard, Vollenweider, Peter, Hayward, Caroline, Wright, Alan F., Rudan, Igor, Groop, Leif C., Metspalu, Andres, Tee Khaw, Kay, van Duijn, Cornelia M., Borecki, Ingrid B., Province, Michael A., Wareham, Nicholas J., Tardif, Jean-Claude, Huikuri, Heikki V., Adrienne Cupples, L., Atwood, Larry D., Fox, Caroline S., Boehnke, Michael, Collins, Francis S., Mohlke, Karen L., Erdmann, Jeanette, Schunkert, Heribert, Hengstenberg, Christian, Stark, Klaus, Lorentzon, Mattias, Ohlsson, Claes, Cusi, Daniele, Staessen, Jan A., Van der Klauw, Melanie M., Pramstaller, Peter P., Kathiresan, Sekar, Jolley, Jennifer D., Ripatti, Samuli, Jarvelin, Marjo-Riitta, de Geus, Eco J. C., Boomsma, Dorret I., Penninx, Brenda, Wilson, James F., Campbell, Harry, Chanock, Stephen J., van der Harst, Pim, Hamsten, Anders, Watkins, Hugh, Hofman, Albert, Witteman, Jacqueline C., Uitterlinden, André G., Rivadeneira, Fernando, Zillikens, M. Carola, Kiemeney, Lambertus A., Vermeulen, Sita H., Abecasis, Goncalo R., Schlessinger, David, Schipf, Sabine, Stumvoll, Michael, Tönjes, Anke, Spector, Tim D., North, Kari E., Lettre, Guillaume, McCarthy, Mark I., Berndt, Sonja I., Heath, Andrew C., Madden, Pamela A. F., Nyholt, Dale R., Montgomery, Grant W., Martin, Nicholas G., McKnight, Barbara, Strachan, David P., Hill, William G., Snieder, Harold, Ridker, Paul M., Thorsteinsdottir, Unnur, Stefansson, Kari, Frayling, Timothy M., Hirschhorn, Joel N., Goddard, Michael E., and Visscher, Peter M.
- Published
- 2012
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29. Hundreds of variants clustered in genomic loci and biological pathways affect human height
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Lango Allen, Hana, Estrada, Karol, Lettre, Guillaume, Berndt, Sonja I., Weedon, Michael N., Rivadeneira, Fernando, Willer, Cristen J., Jackson, Anne U., Vedantam, Sailaja, Raychaudhuri, Soumya, Ferreira, Teresa, Wood, Andrew R., Weyant, Robert J., Segrè, Ayellet V., Speliotes, Elizabeth K., Wheeler, Eleanor, Soranzo, Nicole, Park, Ju-Hyun, Yang, Jian, Gudbjartsson, Daniel, Heard-Costa, Nancy L., Randall, Joshua C., Qi, Lu, Vernon Smith, Albert, Mägi, Reedik, Pastinen, Tomi, Liang, Liming, Heid, Iris M., Luan, Jian’an, Thorleifsson, Gudmar, Winkler, Thomas W., Goddard, Michael E., Sin Lo, Ken, Palmer, Cameron, Workalemahu, Tsegaselassie, Aulchenko, Yurii S., Johansson, Åsa, Carola Zillikens, M., Feitosa, Mary F., Esko, Tõnu, Johnson, Toby, Ketkar, Shamika, Kraft, Peter, Mangino, Massimo, Prokopenko, Inga, Absher, Devin, Albrecht, Eva, Ernst, Florian, Glazer, Nicole L., Hayward, Caroline, Hottenga, Jouke-Jan, Jacobs, Kevin B., Knowles, Joshua W., Kutalik, Zoltán, Monda, Keri L., Polasek, Ozren, Preuss, Michael, Rayner, Nigel W., Robertson, Neil R., Steinthorsdottir, Valgerdur, Tyrer, Jonathan P., Voight, Benjamin F., Wiklund, Fredrik, Xu, Jianfeng, Hua Zhao, Jing, Nyholt, Dale R., Pellikka, Niina, Perola, Markus, Perry, John R. B., Surakka, Ida, Tammesoo, Mari-Liis, Altmaier, Elizabeth L., Amin, Najaf, Aspelund, Thor, Bhangale, Tushar, Boucher, Gabrielle, Chasman, Daniel I., Chen, Constance, Coin, Lachlan, Cooper, Matthew N., Dixon, Anna L., Gibson, Quince, Grundberg, Elin, Hao, Ke, Juhani Junttila, M., Kaplan, Lee M., Kettunen, Johannes, König, Inke R., Kwan, Tony, Lawrence, Robert W., Levinson, Douglas F., Lorentzon, Mattias, McKnight, Barbara, Morris, Andrew P., Müller, Martina, Suh Ngwa, Julius, Purcell, Shaun, Rafelt, Suzanne, Salem, Rany M., Salvi, Erika, Sanna, Serena, Shi, Jianxin, Sovio, Ulla, Thompson, John R., Turchin, Michael C., Vandenput, Liesbeth, Verlaan, Dominique J., Vitart, Veronique, White, Charles C., Ziegler, Andreas, Almgren, Peter, Balmforth, Anthony J., Campbell, Harry, Citterio, Lorena, De Grandi, Alessandro, Dominiczak, Anna, Duan, Jubao, Elliott, Paul, Elosua, Roberto, Eriksson, Johan G., Freimer, Nelson B., Geus, Eco J. C., Glorioso, Nicola, Haiqing, Shen, Hartikainen, Anna-Liisa, Havulinna, Aki S., Hicks, Andrew A., Hui, Jennie, Igl, Wilmar, Illig, Thomas, Jula, Antti, Kajantie, Eero, Kilpeläinen, Tuomas O., Koiranen, Markku, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Laitinen, Jaana, Liu, Jianjun, Lokki, Marja-Liisa, Marusic, Ana, Maschio, Andrea, Meitinger, Thomas, Mulas, Antonella, Paré, Guillaume, Parker, Alex N., Peden, John F., Petersmann, Astrid, Pichler, Irene, Pietiläinen, Kirsi H., Pouta, Anneli, Ridderstråle, Martin, Rotter, Jerome I., Sambrook, Jennifer G., Sanders, Alan R., Oliver Schmidt, Carsten, Sinisalo, Juha, Smit, Jan H., Stringham, Heather M., Bragi Walters, G., Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Zagato, Laura, Zgaga, Lina, Zitting, Paavo, Alavere, Helene, Farrall, Martin, McArdle, Wendy L., Nelis, Mari, Peters, Marjolein J., Ripatti, Samuli, van Meurs, Joyce B. J., Aben, Katja K., Ardlie, Kristin G., Beckmann, Jacques S., Beilby, John P., Bergman, Richard N., Bergmann, Sven, Collins, Francis S., Cusi, Daniele, den Heijer, Martin, Eiriksdottir, Gudny, Gejman, Pablo V., Hall, Alistair S., Hamsten, Anders, Huikuri, Heikki V., Iribarren, Carlos, Kähönen, Mika, Kaprio, Jaakko, Kathiresan, Sekar, Kiemeney, Lambertus, Kocher, Thomas, Launer, Lenore J., Lehtimäki, Terho, Melander, Olle, Mosley, Tom H., Jr, Musk, Arthur W., Nieminen, Markku S., O’Donnell, Christopher J., Ohlsson, Claes, Oostra, Ben, Palmer, Lyle J., Raitakari, Olli, Ridker, Paul M., Rioux, John D., Rissanen, Aila, Rivolta, Carlo, Schunkert, Heribert, Shuldiner, Alan R., Siscovick, David S., Stumvoll, Michael, Tönjes, Anke, Tuomilehto, Jaakko, van Ommen, Gert-Jan, Viikari, Jorma, Heath, Andrew C., Martin, Nicholas G., Montgomery, Grant W., Province, Michael A., Kayser, Manfred, Arnold, Alice M., Atwood, Larry D., Boerwinkle, Eric, Chanock, Stephen J., Deloukas, Panos, Gieger, Christian, Grönberg, Henrik, Hall, Per, Hattersley, Andrew T., Hengstenberg, Christian, Hoffman, Wolfgang, Mark Lathrop, G., Salomaa, Veikko, Schreiber, Stefan, Uda, Manuela, Waterworth, Dawn, Wright, Alan F., Assimes, Themistocles L., Barroso, Inês, Hofman, Albert, Mohlke, Karen L., Boomsma, Dorret I., Caulfield, Mark J., Adrienne Cupples, L., Erdmann, Jeanette, Fox, Caroline S., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B., Hayes, Richard B., Jarvelin, Marjo-Riitta, Mooser, Vincent, Munroe, Patricia B., Ouwehand, Willem H., Penninx, Brenda W., Pramstaller, Peter P., Quertermous, Thomas, Rudan, Igor, Samani, Nilesh J., Spector, Timothy D., Völzke, Henry, Watkins, Hugh, Wilson, James F., Groop, Leif C., Haritunians, Talin, Hu, Frank B., Kaplan, Robert C., Metspalu, Andres, North, Kari E., Schlessinger, David, Wareham, Nicholas J., Hunter, David J., O’Connell, Jeffrey R., Strachan, David P., Wichmann, H.-Erich, Borecki, Ingrid B., van Duijn, Cornelia M., Schadt, Eric E., Thorsteinsdottir, Unnur, Peltonen, Leena, Uitterlinden, André G., Visscher, Peter M., Chatterjee, Nilanjan, Loos, Ruth J. F., Boehnke, Michael, McCarthy, Mark I., Ingelsson, Erik, Lindgren, Cecilia M., Abecasis, Gonçalo R., Stefansson, Kari, Frayling, Timothy M., and Hirschhorn, Joel N.
- Published
- 2010
- Full Text
- View/download PDF
30. Biological, clinical and population relevance of 95 loci for blood lipids
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Teslovich, Tanya M., Musunuru, Kiran, Smith, Albert V., Edmondson, Andrew C., Stylianou, Ioannis M., Koseki, Masahiro, Pirruccello, James P., Ripatti, Samuli, Chasman, Daniel I., Willer, Cristen J., Johansen, Christopher T., Fouchier, Sigrid W., Isaacs, Aaron, Peloso, Gina M., Barbalic, Maja, Ricketts, Sally L., Bis, Joshua C., Aulchenko, Yurii S., Thorleifsson, Gudmar, Feitosa, Mary F., Chambers, John, Orho-Melander, Marju, Melander, Olle, Johnson, Toby, Li, Xiaohui, Guo, Xiuqing, Li, Mingyao, Cho, Yoon Shin, Go, Min Jin, Kim, Young Jin, Lee, Jong-Young, Park, Taesung, Kim, Kyunga, Sim, Xueling, Ong, Rick Twee-Hee, Croteau-Chonka, Damien C., Lange, Leslie A., Smith, Joshua D., Song, Kijoung, Zhao, Jing Hua, Yuan, Xin, Luan, Jian’an, Lamina, Claudia, Ziegler, Andreas, Zhang, Weihua, Zee, Robert Y. L., Wright, Alan F., Witteman, Jacqueline C. M., Wilson, James F., Willemsen, Gonneke, Wichmann, H.-Erich, Whitfield, John B., Waterworth, Dawn M., Wareham, Nicholas J., Waeber, Gérard, Vollenweider, Peter, Voight, Benjamin F., Vitart, Veronique, Uitterlinden, Andre G., Uda, Manuela, Tuomilehto, Jaakko, Thompson, John R., Tanaka, Toshiko, Surakka, Ida, Stringham, Heather M., Spector, Tim D., Soranzo, Nicole, Smit, Johannes H., Sinisalo, Juha, Silander, Kaisa, Sijbrands, Eric J. G., Scuteri, Angelo, Scott, James, Schlessinger, David, Sanna, Serena, Salomaa, Veikko, Saharinen, Juha, Sabatti, Chiara, Ruokonen, Aimo, Rudan, Igor, Rose, Lynda M., Roberts, Robert, Rieder, Mark, Psaty, Bruce M., Pramstaller, Peter P., Pichler, Irene, Perola, Markus, Penninx, Brenda W. J. H., Pedersen, Nancy L., Pattaro, Cristian, Parker, Alex N., Pare, Guillaume, Oostra, Ben A., O’Donnell, Christopher J., Nieminen, Markku S., Nickerson, Deborah A., Montgomery, Grant W., Meitinger, Thomas, McPherson, Ruth, McCarthy, Mark I., McArdle, Wendy, Masson, David, Martin, Nicholas G., Marroni, Fabio, Mangino, Massimo, Magnusson, Patrik K. E., Lucas, Gavin, Luben, Robert, Loos, Ruth J. F., Lokki, Marja-Liisa, Lettre, Guillaume, Langenberg, Claudia, Launer, Lenore J., Lakatta, Edward G., Laaksonen, Reijo, Kyvik, Kirsten O., Kronenberg, Florian, König, Inke R., Khaw, Kay-Tee, Kaprio, Jaakko, Kaplan, Lee M., Johansson, Åsa, Jarvelin, Marjo-Riitta, Janssens, Cecile A. J. W., Ingelsson, Erik, Igl, Wilmar, Hovingh, G. Kees, Hottenga, Jouke-Jan, Hofman, Albert, Hicks, Andrew A., Hengstenberg, Christian, Heid, Iris M., Hayward, Caroline, Havulinna, Aki S., Hastie, Nicholas D., Harris, Tamara B., Haritunians, Talin, Hall, Alistair S., Gyllensten, Ulf, Guiducci, Candace, Groop, Leif C., Gonzalez, Elena, Gieger, Christian, Freimer, Nelson B., Ferrucci, Luigi, Erdmann, Jeanette, Elliott, Paul, Ejebe, Kenechi G., Döring, Angela, Dominiczak, Anna F., Demissie, Serkalem, Deloukas, Panagiotis, de Geus, Eco J. C., de Faire, Ulf, Crawford, Gabriel, Collins, Francis S., Chen, Yii-der I., Caulfield, Mark J., Campbell, Harry, Burtt, Noel P., Bonnycastle, Lori L., Boomsma, Dorret I., Boekholdt, Matthijs S., Bergman, Richard N., Barroso, Inês, Bandinelli, Stefania, Ballantyne, Christie M., Assimes, Themistocles L., Quertermous, Thomas, Altshuler, David, Seielstad, Mark, Wong, Tien Y., Tai, E-Shyong, Feranil, Alan B., Kuzawa, Christopher W., Adair, Linda S., Taylor, Herman A., Jr, Borecki, Ingrid B., Gabriel, Stacey B., Wilson, James G., Holm, Hilma, Thorsteinsdottir, Unnur, Gudnason, Vilmundur, Krauss, Ronald M., Mohlke, Karen L., Ordovas, Jose M., Munroe, Patricia B., Kooner, Jaspal S., Tall, Alan R., Hegele, Robert A., Kastelein, John J.P., Schadt, Eric E., Rotter, Jerome I., Boerwinkle, Eric, Strachan, David P., Mooser, Vincent, Stefansson, Kari, Reilly, Muredach P., Samani, Nilesh J, Schunkert, Heribert, Cupples, Adrienne L., Sandhu, Manjinder S., Ridker, Paul M, Rader, Daniel J., van Duijn, Cornelia M., Peltonen, Leena, Abecasis, Gonçalo R., Boehnke, Michael, and Kathiresan, Sekar
- Published
- 2010
- Full Text
- View/download PDF
31. GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
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Lundgren, Virve M., Isomaa, Bo, Lyssenko, Valeriya, Laurila, Esa, Korhonen, Pasi, Groop, Leif C., and Tuomi, Tiinamaija
- Published
- 2010
32. Estimation of Blood Flow Heterogeneity in Human Skeletal Muscle Using Intravascular Tracer Data: Importance for Modeling Transcapillary Exchange
- Author
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Vicini, Paolo, Bonadonna, Riccardo C., Lehtovirta, Mikko, Groop, Leif C., and Cobelli, Claudio
- Published
- 1998
- Full Text
- View/download PDF
33. Association Studies of BMI and Type 2 Diabetes in the Neuropeptide Y Pathway: A Possible Role for NPY2R as a Candidate Gene for Type 2 Diabetes in Men
- Author
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Campbell, Catarina D., Lyon, Helen N., Nemesh, James, Drake, Jared A., Tuomi, Tiinamaija, Gaudet, Daniel, Zhu, Xiaofeng, Cooper, Richard S., Ardlie, Kristin G., Groop, Leif C., and Hirschhorn, Joel N.
- Published
- 2007
34. Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals
- Author
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Saxena, Richa, Gianniny, Lauren, Burtt, Noël P., Lyssenko, Valeriya, Giuducci, Candace, Sjögren, Marketa, Florez, Jose C., Almgren, Peter, Isomaa, Bo, Orho-Melander, Marju, Lindblad, Ulf, Daly, Mark J., Tuomi, Tiinamaija, Hirschhorn, Joel N., Ardlie, Kristin G., Groop, Leif C., and Altshuler, David
- Published
- 2006
35. Improved Prandial Glucose Control With Lower Risk of Hypoglycemia With Nateglinide Than With Glibenclamide in Patients With Maturity-Onset Diabetes of the Young Type 3
- Author
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TUOMI, TIINAMAIJA, HONKANEN, ELINA H., ISOMAA, BO, SARELIN, LEENA, and GROOP, LEIF C.
- Published
- 2006
36. Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen
- Author
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Salem, Rany M., Todd, Jennifer N., Sandholm, Niina, Cole, Joanne B., Chen, Wei-Min, Andrews, Darrell, Pezzolesi, Marcus G., McKeigue, Paul M., Hiraki, Linda T., Qiu, Chengxiang, Nair, Viji, Di Liao, Chen, Cao, Jing Jing, Valo, Erkka, Onengut-Gumuscu, Suna, Smiles, Adam M., McGurnaghan, Stuart J., Haukka, Jani K., Harjutsalo, Valma, Brennan, Eoin P., van Zuydam, Natalie, Ahlqvist, Emma, Doyle, Ross, Ahluwalia, Tarunveer S., Lajer, Maria, Hughes, Maria F., Park, Jihwan, Skupien, Jan, Spiliopoulou, Athina, Liu, Andrew, Menon, Rajasree, Boustany-Kari, Carine M., Kang, Hyun M., Nelson, Robert G., Klein, Ronald, Klein, Barbara E., Lee, Kristine E., Gao, Xiaoyu, Mauer, Michael, Maestroni, Silvia, Caramori, Maria Luiza, de Boer, Ian H., Miller, Rachel G., Guo, Jingchuan, Boright, Andrew P., Tregouet, David, Gyorgy, Beata, Snell-Bergeon, Janet K., Maahs, David M., Bull, Shelley B., Canty, Angelo J., Palmer, Colin N. A., Stechemesser, Lars, Paulweber, Bernhard, Weitgasser, Raimund, Sokolovska, Jelizaveta, Rovite, Vita, Pirags, Valdis, Prakapiene, Edita, Radzeviciene, Lina, Verkauskiene, Rasa, Panduru, Nicolae Mircea, Groop, Leif C., McCarthy, Mark, I, Gu, Harvest F., Möllsten, Anna, Falhammar, Henrik, Brismar, Kerstin, Martin, Finian, Rossing, Peter, Costacou, Tina, Zerbini, Gianpaolo, Marre, Michel, Hadjadj, Samy, McKnight, Amy J., Forsblom, Carol, McKay, Gareth, Godson, Catherine, Maxwell, A. Peter, Kretzler, Matthias, Susztak, Katalin, Colhoun, Helen M., Krolewski, Andrzej, Paterson, Andrew D., Groop, Per-Henrik, Rich, Stephen S., Hirschhorn, Joel N., Florez, Jose C., Salem, Rany M., Todd, Jennifer N., Sandholm, Niina, Cole, Joanne B., Chen, Wei-Min, Andrews, Darrell, Pezzolesi, Marcus G., McKeigue, Paul M., Hiraki, Linda T., Qiu, Chengxiang, Nair, Viji, Di Liao, Chen, Cao, Jing Jing, Valo, Erkka, Onengut-Gumuscu, Suna, Smiles, Adam M., McGurnaghan, Stuart J., Haukka, Jani K., Harjutsalo, Valma, Brennan, Eoin P., van Zuydam, Natalie, Ahlqvist, Emma, Doyle, Ross, Ahluwalia, Tarunveer S., Lajer, Maria, Hughes, Maria F., Park, Jihwan, Skupien, Jan, Spiliopoulou, Athina, Liu, Andrew, Menon, Rajasree, Boustany-Kari, Carine M., Kang, Hyun M., Nelson, Robert G., Klein, Ronald, Klein, Barbara E., Lee, Kristine E., Gao, Xiaoyu, Mauer, Michael, Maestroni, Silvia, Caramori, Maria Luiza, de Boer, Ian H., Miller, Rachel G., Guo, Jingchuan, Boright, Andrew P., Tregouet, David, Gyorgy, Beata, Snell-Bergeon, Janet K., Maahs, David M., Bull, Shelley B., Canty, Angelo J., Palmer, Colin N. A., Stechemesser, Lars, Paulweber, Bernhard, Weitgasser, Raimund, Sokolovska, Jelizaveta, Rovite, Vita, Pirags, Valdis, Prakapiene, Edita, Radzeviciene, Lina, Verkauskiene, Rasa, Panduru, Nicolae Mircea, Groop, Leif C., McCarthy, Mark, I, Gu, Harvest F., Möllsten, Anna, Falhammar, Henrik, Brismar, Kerstin, Martin, Finian, Rossing, Peter, Costacou, Tina, Zerbini, Gianpaolo, Marre, Michel, Hadjadj, Samy, McKnight, Amy J., Forsblom, Carol, McKay, Gareth, Godson, Catherine, Maxwell, A. Peter, Kretzler, Matthias, Susztak, Katalin, Colhoun, Helen M., Krolewski, Andrzej, Paterson, Andrew D., Groop, Per-Henrik, Rich, Stephen S., Hirschhorn, Joel N., and Florez, Jose C.
- Abstract
Background: Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain largely unknown. Methods: To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide association study (GWAS) analyses. Through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, we assembled a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes. We used a spectrum of ten diabetic kidney disease definitions based on albuminuria and renal function. Results: Our GWAS meta-analysis included association results for up to 19,406 individuals of European descent with type 1 diabetes. We identified 16 genome-wide significant risk loci. The variant with the strongest association (rs55703767) is a common missense mutation in the collagen type IV alpha 3 chain (COL4A3) gene, which encodes a major structural component of the glomerular basement membrane (GBM). Mutations in COL4A3 are implicated in heritable nephropathies, including the progressive inherited nephropathy Alport syndrome. The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of diabetic kidney disease, including albuminuria and ESKD, and demonstrated a significant association with GBM width; protective allele carriers had thinner GBM before any signs of kidney disease, and its effect was dependent on glycemia. Three other loci are in or near genes with known or suggestive involvement in this condition (BMP7) or renal biology (COLEC11 and DDR1). Conclusions: The 16 diabetic kidney disease–associated loci may provide novel insights into the pathogenesis of this condition and help identify potential biologic targets for prevention and treatment.
- Published
- 2019
- Full Text
- View/download PDF
37. Association of a polymorphism in the beta3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
- Author
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Widen, Elisabeth, Lehto, Markku, Kanninen, Timo, Walston, Jeremy, Shuldiner, Alan R., and Groop, Leif C.
- Subjects
Type 2 diabetes -- Genetic aspects ,Epinephrine -- Receptors - Abstract
A mutation in a gene coding for a receptor involved in fat metabolism may play a role in the development of obesity and non-insulin-dependent diabetes mellitus (NIDDM). Genetic analysis was carried out in a group of 128 Finns with NIDDM, 207 non-diabetic Finns, and 17 pairs of siblings with normal glucose metabolism where one sibling carried the mutation on both chromosomes and the other did not. Glucose metabolism was evaluated, and measurements were made of body lean tissue, waist and hip circumference, and blood pressure. Non-diabetic participants carrying the mutation were more likely to be fatter around the waist, resistant to insulin, and to have higher blood pressure. Diabetes onset occurred at an earlier age in carriers. Siblings carrying the mutation on both chromosomes tended to be fatter than siblings who had one normal chromosome, and siblings carrying the mutation were more insulin resistant than siblings with normal genes.
- Published
- 1995
38. A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2–q22 linked to type 2 diabetes
- Author
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Demenais, Florence, Kanninen, Timo, Lindgren, Cecilia M., Wiltshire, Steven, Gaget, Stéphane, Dandrieux, Candice, Almgren, Peter, Sjögren, Marketa, Hattersley, Andrew, Dina, Christian, Tuomi, Tiinamaija, McCarthy, Mark I., Froguel, Philippe, and Groop, Leif C.
- Published
- 2003
39. A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity
- Author
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Frayling, Timothy M., Lindgren, Cecilia M., Chevre, Jean Claude, Menzel, Stephan, Wishart, Marie, Benmezroua, Yamina, Brown, Alison, Evans, Julie C., Rao, Pamidghantam Subba, Dina, Christian, Lecoeur, Cécile, Kanninen, Timo, Almgren, Peter, Bulman, Michael P., Wang, Youxiang, Mills, James, Wright-Pascoe, Rosemarie, Mahtani, Melanie M., Prisco, Francesco, Costa, Angels, Cognet, Ignacio, Hansen, Torben, Pedersen, Oluf, Ellard, Sian, Tuomi, Tiinamaija, Groop, Leif C., Froguel, Philippe, Hattersley, Andrew T., and Vaxillaire, Martine
- Published
- 2003
40. Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle
- Author
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Bonadonna, Riccardo C., Groop, Leif C., Simonson, Donald C., and DeFronzo, R.A.
- Subjects
Glucose metabolism -- Analysis ,Fatty acid metabolism -- Analysis ,Aging -- Molecular aspects ,Biological sciences - Abstract
Studies on the role of free fatty acid and glucose metabolism in human aging reveals that the substrate competition between fat and glucose may reduce the insulin-mediated glucose oxidation. The abnormal insulin regulation of free fatty acid/lipid metabolism is the next major factor involved. Glucose oxidation is lower in the elderly than the young at all insulin concentrations.
- Published
- 1994
41. Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria
- Author
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Viberti, Giancarlo, Mogensen, Carl Erik, Groop, Leif C., and Pauls, John F.
- Subjects
Captopril -- Evaluation ,Proteinuria -- Prevention ,Type 1 diabetes -- Drug therapy - Abstract
Captopril therapy for patients with diabetes and microalbuminuria may prevent the development of proteinuria. Captopril inhibits the action of angiotensin converting enzymes and is used to treat high blood pressure. Proteinuria and microalbuminuria are the presence of excess blood proteins in the urine. Researchers assigned 92 diabetes patients to receive either 50 milligrams of captopril or a placebo twice daily. After 24 months, 12 patients receiving the placebo and four patients receiving captopril developed proteinuria. Albumin protein excretion rates increased significantly among patients given the placebo, while they decreased substantially among patients given captopril. Urinary albumin excretion increased by 18.3% per year in placebo-treated patients and only 2.1% per year in captopril-treated patients. Average blood pressure did not change among the placebo-treated group, but fell significantly among the captopril-treated group., Objectives.--To study the effect of angiotensin converting enzyme inhibition on the rate of progression to clinical proteinuria and the rate of change of albumin excretion rates in patients with insulin-dependent diabetes mellitus and persistent microalbuminuria. Design and Setting.--Randomized, double-blind, placebo-controlled clinical trial of 2 years' duration at 12 hospital-based diabetes centers. Patients.--Ninety-two patients with insulin-dependent diabetes mellitus and persistent microalbuminuria but no hypertension. Intervention.--The patients were randomly allocated in blocks of two to receive either captopril, 50 mg, or placebo twice per day. Measurements.--Albumin excretion rate, blood pressure, glycosylated hemoglobin level, and fructosamine level every 3 months; urinary urea nitrogen excretion every 6 months; and glomerular filtration rate every 12 months. Results.--Twelve patients receiving placebo and four receiving captopril progressed to clinical proteinuria, defined as an albumin excretion rate persistently greater than 200 [mu]g/min and at least a 30% increase from baseline (P=.05). The probability of progression to clinical proteinuria was significantly reduced by captopril therapy (P=.03 by log-rank test). Albumin excretion rate rose from a geometric mean (95% confidence interval) of 52 (39 to 68) to 76 (47 to 122) [mu]g/min in the placebo group but fell from 52 (41 to 65) to 41 (28 to 60) [mu]g/min in the captopril group, a significant difference (P
- Published
- 1994
42. Contribution of Known and Unknown Susceptibility Genes to Early-Onset Diabetes in Scandinavia: Evidence for Heterogeneity
- Author
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Lindgren, Cecilia M., Widén, Elisabeth, Tuomi, Tiinamaija, Li, Haiyan, Almgren, Peter, Kanninen, Timo, Melander, Olle, Weng, Jianping, Lehto, Markku, and Groop, Leif C.
- Published
- 2002
43. 5′ Flanking Variants of Resistin Are Associated With Obesity
- Author
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Engert, James C., Vohl, Marie-Claude, Williams, Scott M., Lepage, Pierre, Loredo-Osti, J C., Faith, Janet, Doré, Carole, Renaud, Yannick, Burtt, Noël P., Villeneuve, Amélie, Hirschhorn, Joel N., Altshuler, David, Groop, Leif C., Després, Jean-Pierre, Gaudet, Daniel, and Hudson, Thomas J.
- Published
- 2002
44. Screening for MODY Mutations, GAD Antibodies, and Type 1 Diabetes-Associated HLA Genotypes in Women With Gestational Diabetes Mellitus
- Author
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Weng, Jianping, Ekelund, Magnus, Lehto, Markku, Li, Haiyan, Ekberg, Göran, Frid, Anders, Åberg, Anders, Groop, Leif C., and Berntorp, Kerstin
- Published
- 2002
45. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus
- Author
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Groop, Leif C., Kankuri, Maija, Schalin-Jantti, Camilla, Ekstrand, Agneta, Nikula-Ijas, Pirjo, Widen, Elisabeth, Kuismanen, Esa, Eriksson, Johan, Franssila-Kallunki, Anja, Saloranta, Carola, and Koskimies, Saija
- Subjects
Type 2 diabetes -- Genetic aspects ,Glycogen -- Synthesis ,Genetic polymorphisms -- Physiological aspects - Abstract
Polymorphism of the glycogen synthase gene is associated with non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. NIDDM is characterized by defective glycogen synthesis and insulin resistance and is thought to be a genetic disease. Impairment or inactivation of the gene for glycogen synthase, an enzyme involved in glycogen synthesis, might explain this defect. DNA probes of 107 patients with NIDDM and 164 non-diabetic individuals with no family history of NIDDM revealed two polymorphic alleles for the glycogen synthase gene, labelled A1 and A2. Thirty percent of the patients with NIDDM had either the A1A2 or A2A2 genotype compared with only 8% of patients without NIDDM. Diabetics with the A2 allele had a significantly greater incidence of high blood pressure and insulin resistance and had an extensive family history of NIDDM. The presence of the A2 allele could be considered an indicator of NIDDM.
- Published
- 1993
46. Inhibition of the Rise in FFA by Acipimox Partially Prevents GH-Induced Insulin Resistance in GH-Deficient Adults
- Author
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Segerlantz, Mikael, Bramnert, Margareta, Manhem, Per, Laurila, Esa, and Groop, Leif C.
- Published
- 2001
47. Characterization of the Annexin I Gene and Evaluation of Its Role in Type 2 Diabetes
- Author
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Lindgren, Cecilia M., Nilsson, Anita, Orho-Melander, Marju, Almgren, Peter, and Groop, Leif C.
- Published
- 2001
48. A Gene Conferring Susceptibility to Type 2 Diabetes in Conjunction With Obesity Is Located on Chromosome 18p11
- Author
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Parker, Alex, Meyer, Joanne, Lewitzky, Steve, Rennich, Jean S., Chan, Gayun, Thomas, Jeffrey D., Orho-Melander, Marju, Lehtovirta, Mikko, Forsblom, Carol, Hyrkkö, Auli, Carlsson, Martin, Lindgren, Cecilia, and Groop, Leif C.
- Published
- 2001
49. Association Between the Human Glycoprotein PC-1 Gene and Elevated Glucose and Insulin Levels in a Paired-Sibling Analysis
- Author
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Gu, Harvest F., Almgren, Peter, Lindholm, Eero, Frittitta, Lucia, Pizzuti, Antonio, Trischitta, Vincenzo, and Groop, Leif C.
- Published
- 2000
50. The T 54 Allele of the Intestinal Fatty Acid-Binding Protein 2 Is Associated with a Parental History of Stroke*
- Author
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Carlsson, Martin, Orho-Melander, Marju, Hedenbro, Jan, Almgren, Peter, and Groop, Leif C
- Published
- 2000
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