Search

Your search keyword '"Gromowski, Tomasz"' showing total 34 results
Start Over Author "Gromowski, Tomasz"
34 results on '"Gromowski, Tomasz"'

3. Gut microbiome dynamics and predictive value in hospitalized COVID-19 patients: a comparative analysis of shallow and deep shotgun sequencing.

Author

Kopera, Katarzyna, Gromowski, Tomasz, Wydmański, Witold, Skonieczna-Żydecka, Karolina, Muszyńska, Agata, Zielińska, Kinga, Wierzbicka-Woś, Anna, Kaczmarczyk, Mariusz, Kadaj-Lipka, Roland, Cembrowska-Lech, Danuta, Januszkiewicz, Kornelia, Kotfis, Katarzyna, Witkiewicz, Wojciech, Nalewajska, Magdalena, Feret, Wiktoria, Marlicz, Wojciech, Łoniewski, Igor, Łabaj, Paweł P., Rydzewska, Grażyna, and Kosciolek, Tomasz

Subjects
SHOTGUN sequencing, COVID-19, GUT microbiome, DEEP brain stimulation, REVERSE transcriptase polymerase chain reaction, ANTIBIOTIC residues, SURVIVAL analysis (Biometry), HOSPITAL patients
Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has led to a wide range of clinical presentations, with respiratory symptoms being common. However, emerging evidence suggests that the gastrointestinal (GI) tract is also affected, with angiotensin-converting enzyme 2, a key receptor for SARS-CoV-2, abundantly expressed in the ileum and colon. The virus has been detected in GI tissues and fecal samples, even in cases with negative results of the reverse transcription polymerase chain reaction in the respiratory tract. GI symptoms have been associated with an increased risk of ICU admission and mortality. The gut microbiome, a complex ecosystem of around 40 trillion bacteria, plays a crucial role in immunological and metabolic pathways. Dysbiosis of the gut microbiota, characterized by a loss of beneficial microbes and decreased microbial diversity, has been observed in COVID-19 patients, potentially contributing to disease severity. We conducted a comprehensive gut microbiome study in 204 hospitalized COVID-19 patients using both shallow and deep shotgun sequencing methods. We aimed to track microbiota composition changes induced by hospitalization, link these alterations to clinical procedures (antibiotics administration) and outcomes (ICU referral, survival), and assess the predictive potential of the gut microbiome for COVID-19 prognosis. Shallow shotgun sequencing was evaluated as a cost-effective diagnostic alternative for clinical settings. Our study demonstrated the diverse effects of various combinations of clinical parameters, microbiome profiles, and patient metadata on the precision of outcome prognostication in patients. It indicates that microbiological data possesses greater reliability in forecasting patient outcomes when contrasted with clinical data or metadata. Furthermore, we established that shallow shotgun sequencing presents a viable and costeffective diagnostic alternative to deep sequencing within clinical environments. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Author

Białkowska, Katarzyna, Marciniak, Wojciech, Muszyńska, Magdalena, Baszuk, Piotr, Gupta, Satish, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Durda, Katarzyna, Gromowski, Tomasz, Lener, Marcin, Prajzendanc, Karolina, Łukomska, Alicja, Cybulski, Cezary, Huzarski, Tomasz, Gronwald, Jacek, Dębniak, Tadeusz, Lubiński, Jan, and Jakubowska, Anna

Published
2020
Full Text
View/download PDF

5. The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men

Author

Polish Hereditary Prostate Cancer Consortium, Antczak, Andrzej, Wokołorczyk, Dominika, Kluźniak, Wojciech, Kashyap, Aniruddh, Jakubowska, Anna, Gronwald, Jacek, Huzarski, Tomasz, Byrski, Tomasz, Dębniak, Tadeusz, Masojć, Bartłomiej, Górski, Bohdan, Gromowski, Tomasz, Gołąb, Adam, Sikorski, Andrzej, Słojewski, Marcin, Gliniewicz, Bartłomiej, Borkowski, Tomasz, Borkowski, Andrzej, Przybyła, Jacek, Sosnowski, Marek, Małkiewicz, Bartosz, Zdrojowy, Romuald, Sikorska-Radek, Paulina, Matych, Józef, Wilkosz, Jacek, Różański, Waldemar, Kiś, Jacek, Bar, Krzysztof, Janiszewska, Hanna, Stawicka, Małgorzata, Milecki, Piotr, Lubiński, Jan, Narod, Steven A., and Cybulski, Cezary

Published
2015

6. Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Author

BiaÅkowska, Katarzyna, Marciniak, Wojciech, MuszyÅska, Magdalena, Baszuk, Piotr, Gupta, Satish, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Durda, Katarzyna, Gromowski, Tomasz, Lener, Marcin, Prajzendanc, Karolina, Åukomska, Alicja, Cybulski, Cezary, Huzarski, Tomasz, Gronwald, Jacek, DÄbniak, Tadeusz, LubiÅski, Jan, and Jakubowska, Anna

Subjects
Colon cancer -- Genetic aspects -- Development and progression -- Risk factors, Apoptosis -- Genetic aspects -- Health aspects, Zinc (Nutrient) -- Genetic aspects -- Health aspects, Cancer research -- Health aspects -- Genetic aspects, Genes -- Genetic aspects -- Health aspects, Single nucleotide polymorphisms -- Genetic aspects -- Health aspects, Prostate cancer -- Risk factors -- Genetic aspects -- Development and progression, Gene expression -- Genetic aspects -- Health aspects, Proteins -- Genetic aspects -- Health aspects, Health
Abstract

Background Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. Methods The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn. Results None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed. Conclusions Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation. Keywords: Prostate cancer, Matrix metalloproteinases, Metallothioneins, Polymorphisms, Author(s): Katarzyna BiaÅkowska[sup.1], Wojciech Marciniak[sup.2], Magdalena MuszyÅska[sup.2], Piotr Baszuk[sup.1], Satish Gupta[sup.3], Katarzyna Jaworska-Bieniek[sup.1], Grzegorz Sukiennicki[sup.1], Katarzyna Durda[sup.1], Tomasz Gromowski[sup.1], Marcin Lener[sup.1], Karolina Prajzendanc[sup.1], Alicja Åukomska[sup.1], Cezary Cybulski[sup.1], Tomasz Huzarski[sup.1], Jacek [...]

Published
2020
Full Text
View/download PDF

9. CHAPTER 22. Selenium and Cancer

Author

Jaworska-Bieniek, Katarzyna, primary, Lener, Marcin, additional, Muszynska, Magdalena, additional, Serrano-Fernández, Pablo, additional, Sukiennicki, Grzegorz, additional, Durda, Katarzyna, additional, Gromowski, Tomasz, additional, Gupta, Satish, additional, Kladny, Józef, additional, Wiechowska-Kozlowska, Anna, additional, Grodzki, Tomasz, additional, Jaworowska, Ewa, additional, Lubinski, Jakub, additional, Górecka-Szyld, Barbara, additional, Wilk, Grazyna, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Cybulski, Cezary, additional, Gronwald, Jacek, additional, Debniak, Tadeusz, additional, Ashuryk, Olgierd, additional, Toloczko-Grabarek, Aleksandra, additional, Morawski, Antoni, additional, Scott, Rodney J., additional, Jakubowska, Anna, additional, and Lubinski, Jan, additional

Published
2015
Full Text
View/download PDF

10. Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021

Author

Mazur-Panasiuk, Natalia, primary, Rabalski, Lukasz, additional, Gromowski, Tomasz, additional, Nowicki, Grzegorz, additional, Kowalski, Michal, additional, Wydmanski, Witold, additional, Szulc, Piotr, additional, Kosinski, Maciej, additional, Gackowska, Karolina, additional, Drweska-Matelska, Natalia, additional, Grabowski, Jakub, additional, Piotrowska-Mietelska, Anna, additional, Szewczyk, Boguslaw, additional, Bienkowska-Szewczyk, Krystyna, additional, Swadzba, Jakub, additional, Labaj, Pawel, additional, Grzybek, Maciej, additional, and Pyrc, Krzysztof, additional

Published
2021
Full Text
View/download PDF

11. Arsenic (As) and breast cancer risk

Author

Muszyńska Magdalena, Jaworska-Bieniek Katarzyna, Durda Katarzyna, Sukiennicki Grzegorz, Gromowski Tomasz, Jakubowska Anna, Morawski Antoni, and Lubiński Jan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470
Abstract

Abstract The study was conducted to determine the correlations between serum concentration of arsenic (As) with increased or decreased predisposition to breast and ovarian cancer.

Published
2012
Full Text
View/download PDF

12. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer

Author

Magierowska, Katarzyna, primary, Korbut, Edyta, additional, Hubalewska-Mazgaj, Magdalena, additional, Surmiak, Marcin, additional, Chmura, Anna, additional, Bakalarz, Dominik, additional, Buszewicz, Grzegorz, additional, Wójcik, Dagmara, additional, Śliwowski, Zbigniew, additional, Ginter, Grzegorz, additional, Gromowski, Tomasz, additional, Kwiecień, Sławomir, additional, Brzozowski, Tomasz, additional, and Magierowski, Marcin, additional

Published
2019
Full Text
View/download PDF

13. Microelements as diagnostic markers of pancreatic cancer

Author

Lener, Marcin, Wiechowska-KozÅowska, Anna, MuszyÅska, Magdalena, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Kaczmarek, Katarzyna, Gromowski, Tomasz, Marciniak, Wojciech, Jakubowska, Anna, and LubiÅski, Jan

Subjects
Trace elements in nutrition -- Health aspects, Biological markers -- Identification and classification -- Health aspects, Pancreatic cancer -- Diagnosis, Health
Abstract

Author(s): Marcin Lener[sup.1] , Anna Wiechowska-KozÅowska[sup.2] , Magdalena MuszyÅska[sup.3] , Katarzyna Jaworska-Bieniek[sup.1] , Grzegorz Sukiennicki[sup.1] , Katarzyna Kaczmarek[sup.1] , Tomasz Gromowski[sup.1] , Wojciech Marciniak[sup.3] , Anna Jakubowska[sup.1] and Jan LubiÅski[sup.1,3] [...]

Published
2015
Full Text
View/download PDF

14. Zinc as diagnostic marker of cancers

Author

Kaczmarek, Katarzyna, MuszyÅska, Magdalena, Jaworska-Bieniek, Katarzyna, Marciniak, Wojciech, Sukiennicki, Grzegorz, Lener, Marcin, Durda, Katarzyna, Gromowski, Tomasz, Huzarski, Tomasz, Byrski, Tomasz, Gronwald, Jacek, Oszurek, Oleg, Cybulski, Cezary, DÄbniak, Tadeusz, Morawski, Antoni, Jakubowska, Anna, and LubiÅski, Jan

Subjects
Cancer -- Diagnosis, Zinc in the body -- Health aspects -- Innovations, Biological markers -- Identification and classification -- Health aspects, Health
Abstract

Author(s): Katarzyna Kaczmarek[sup.1] , Magdalena MuszyÅska[sup.2] , Katarzyna Jaworska-Bieniek[sup.1] , Wojciech Marciniak[sup.2] , Grzegorz Sukiennicki[sup.1] , Marcin Lener[sup.1] , Katarzyna Durda[sup.1] , Tomasz Gromowski[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] [...]

Published
2015
Full Text
View/download PDF

15. Iron as diagnostic marker of cancer

Author

Sukiennicki, Grzegorz, MuszyÅska, Magdalena, Jaworska-Bieniek, Katarzyna, Kaczmarek, Katarzyna, Marciniak, Wojciech, Lener, Marcin, Durda, Katarzyna, Gromowski, Tomasz, Huzarski, Tomasz, Byrski, Tomasz, Gronwald, Jacek, Oszurek, Oleg, Cybulski, Cezary, DÄbniak, Tadeusz, Morawski, Antoni, Jakubowska, Anna, and LubiÅski, Jan

Subjects
Iron in the body -- Health aspects -- Innovations, Cancer -- Diagnosis, Biological markers -- Identification and classification -- Health aspects, Health
Abstract

Author(s): Grzegorz Sukiennicki[sup.1] , Magdalena MuszyÅska[sup.2] , Katarzyna Jaworska-Bieniek[sup.1] , Katarzyna Kaczmarek[sup.1] , Wojciech Marciniak[sup.2] , Marcin Lener[sup.1] , Katarzyna Durda[sup.1] , Tomasz Gromowski[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] [...]

Published
2015
Full Text
View/download PDF

16. Selenium as diagnostic marker of cancers

Author

Jaworska-Bieniek, Katarzyna, MuszyÅska, Magdalena, Kaczmarek, Katarzyna, Marciniak, Wojciech, Sukiennicki, Grzegorz, Lener, Marcin, Durda, Katarzyna, Gromowski, Tomasz, Huzarski, Tomasz, Byrski, Tomasz, Gronwald, Jacek, Oszurek, Oleg, Cybulski, Cezary, DÄbniak, Tadeusz, Morawski, Antoni, Jakubowska, Anna, and LubiÅski, Jan

Subjects
Carcinogenesis -- Development and progression, Biological markers -- Identification and classification, Health
Abstract

Author(s): Katarzyna Jaworska-Bieniek[sup.1] , Magdalena MuszyÅska[sup.2] , Katarzyna Kaczmarek[sup.1] , Wojciech Marciniak[sup.2] , Grzegorz Sukiennicki[sup.1] , Marcin Lener[sup.1] , Katarzyna Durda[sup.1] , Tomasz Gromowski[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] [...]

Published
2015
Full Text
View/download PDF

17. Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families

Author

DÄbniak, Tadeusz, Gromowski, Tomasz, Scott, Rodney J, Gronwald, Jacek, Huzarski, Tomasz, Byrski, Tomasz, Kurzawski, Grzegorz, Dymerska, Dagmara, Górski, Bohdan, Paszkowska-Szczur, Katarzyna, Cybulski, Cezary, Serrano-Fernandez, Pablo, and LubiÅski, Jan

Subjects
Women -- Health aspects -- Research, Cancer -- Prevention, Ovarian cancer -- Genetic aspects -- Prevention -- Research -- Care and treatment
Abstract

Background Over half the cancer deaths in HNPCC families are due to extra-colonic malignancies that include endometrial and ovarian cancers. The benefits of surveillance for gynecological cancers are not yet proven and there is no consensus on the optimal surveillance recommendations for women with MMR mutations. Methods We performed a systematic review of the literature and evaluated gynecological cancer risk in a series of 631 Polish HNPCC families classified into either Lynch Syndrome (LS, MMR mutations detected) or HNPCC (fulfillment of the Amsterdam or modified Amsterdam criteria). Results Published data clearly indicates no benefit for ovarian cancer screening in contrast to risk reducing surgery. We confirmed a significantly increased risk of OC in Polish LS families (OR = 4,6, p < 0.001) and an especially high risk of OC was found for women under 50 years of age: OR = 32,6, p < 0.0001 (95% CI 12,96-81,87). The cumulative OC risk to 50 year of life was calculated to be 10%. Six out of 19 (32%) early-onset patients from LS families died from OC within 2 years of diagnosis. We confirmed a significantly increased risk of EC (OR = 26, 95% CI 11,36-58,8; p < 0,001). The cumulative risk for EC in Polish LS families was calculated to be 67%. Conclusions Due to the increased risk of OC and absence of any benefit from gynecological screening reported in the literature it is recommended that prophylactic oophorectomy for female carriers of MMR mutations after 35 year of age should be considered as a risk reducing option. Annual transvaginal ultrasound supported by CA125 or HE4 marker testing should be performed after prophylactic surgery in these women. Due to the high risk of EC it is reasonable to offer, after the age of 35 years, annual clinical gynecologic examinations with transvaginal ultrasound supported by routine aspiration sampling of the endometrium for women from either LS or HNPCC families. An alternative option, which could be taken into consideration for women preferring surgical prevention, is risk reducing total hysterectomy (with bilateral salpingo-oophorectomy) for carriers after childbearing is complete. Keywords: HNPCC, Lynch syndrome, Ovarian cancer, Endometrial cancer, Adnexectomy, Author(s): Tadeusz DÄbniak[sup.1] , Tomasz Gromowski[sup.1] , Rodney J Scott[sup.2] , Jacek Gronwald[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] , Grzegorz Kurzawski[sup.1] , Dagmara Dymerska[sup.1] , Bohdan Górski[sup.1] , Katarzyna [...]

Published
2015
Full Text
View/download PDF

18. Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland

Author

Dębniak, Tadeusz, primary, Scott, Rodney J, additional, Lea, Rodney A, additional, Górski, Bohdan, additional, Masojć, Bartłomiej, additional, Cybulski, Cezary, additional, Kram, Andrzej, additional, Maleszka, Romuald, additional, Gromowski, Tomasz, additional, Paszkowska-Szczur, Katarzyna, additional, Kashyap, Aniruddh, additional, Lener, Marcin R., additional, Malińska, Karolina, additional, Rogoża, Emilia, additional, Murawa, Dawid, additional, Rudnicka, Helena, additional, Deptuła, Jakub, additional, and Lubiński, Jan, additional

Published
2019
Full Text
View/download PDF

19. Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence

Author

Sukiennicki, Grzegorz Mariusz, primary, Marciniak, Wojciech, additional, Muszyńska, Magdalena, additional, Baszuk, Piotr, additional, Gupta, Satish, additional, Białkowska, Katarzyna, additional, Jaworska-Bieniek, Katarzyna, additional, Durda, Katarzyna, additional, Lener, Marcin, additional, Pietrzak, Sandra, additional, Gromowski, Tomasz, additional, Prajzendanc, Karolina, additional, Łukomska, Alicja, additional, Waloszczyk, Piotr, additional, Wójcik, Janusz Zenon, additional, Scott, Rodney, additional, Lubiński, Jan, additional, and Jakubowska, Anna, additional

Published
2019
Full Text
View/download PDF

20. Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population

Author

Białkowska, Katarzyna, primary, Marciniak, Wojciech, additional, Muszyńska, Magdalena, additional, Baszuk, Piotr, additional, Gupta, Satish, additional, Jaworska-Bieniek, Katarzyna, additional, Sukiennicki, Grzegorz, additional, Durda, Katarzyna, additional, Gromowski, Tomasz, additional, Prajzendanc, Karolina, additional, Cybulski, Cezary, additional, Huzarski, Tomasz, additional, Gronwald, Jacek, additional, Dębniak, Tadeusz, additional, Scott, Rodney J., additional, Lubiński, Jan, additional, and Jakubowska, Anna, additional

Published
2018
Full Text
View/download PDF

21. Meeting abstracts from the Annual Conference on Hereditary Cancers 2015

Author

Thompson, Ella R., primary, Wong-Brown, Michelle, additional, Rowley, Simone M., additional, Dooley, Susan, additional, Lil, Na, additional, Hipwell, Michael, additional, McInerny, Simone, additional, Meldrum, Cliff, additional, Devereux, Lisa, additional, Mossman, David, additional, Trainer, Alison H., additional, Millar, Briar-Rose, additional, Mitchell, Gillian, additional, Smith, Cate, additional, James, Paul A., additional, Campbell, Ian G., additional, Scott, Rodney J., additional, Klonowska, Katarzyna, additional, Jakubowska, Anna, additional, Maksimenko, Jelena, additional, Irmejs, Arvids, additional, Nakazawa-Miklasevica, Miki, additional, Melbarde-Gorkusa, Inga, additional, Trofimovics, Genadijs, additional, Gardovskis, Janis, additional, Miklasevics, Edvins, additional, Tęcza, Karolina, additional, Pamuła-Piłat, Jolanta, additional, Łanuszewska, Joanna, additional, Grzybowska, Ewa, additional, Szwiec, M., additional, Tomiczek-Szwiec, J., additional, Gełej, M., additional, Cybulski, C., additional, Huzarski, T., additional, Kilar, E., additional, Oczko-Wojciechowska, Małgorzata, additional, Świerniak, Michał, additional, Krajewska, Jolanta, additional, Kowalska, Małgorzata, additional, Tyszkiewicz, Tomasz, additional, Pawlaczek, Agnieszka, additional, Jarząb, Michał, additional, Kowal, Monika, additional, Rusinek, Dagmara, additional, Zebracka-Gala, Jadwiga, additional, Czarniecka, Agnieszka, additional, Jarzab, Barbara, additional, Plawski, Andrzej, additional, Borun, Paweł, additional, Szczepinska, Joanna, additional, Siolek, Monika, additional, Kozak-Klonowska, Beata, additional, Kaczmarek, Katarzyna, additional, Muszyńska, Magdalena, additional, Marciniak, Wojciech, additional, Sukiennicki, Grzegorz, additional, Lener, Marcin, additional, Durda, Katarzyna, additional, Jaworska-Bieniek, Katarzyna, additional, Gromowski, Tomasz, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Gronwald, Jacek, additional, Oszurek, Oleg, additional, Cybulski, Cezary, additional, Dębniak, Tadeusz, additional, Morawski, Antoni, additional, Lubiński, Jan, additional, and Post, Michał, additional

Published
2017
Full Text
View/download PDF

22. Serum 25(OH)D concentration, common variants of theVDRgene and lung cancer occurrence

Author

Gromowski, Tomasz, primary, Gapska, Paulina, additional, Scott, Rodney J., additional, Kąklewski, Krzysztof, additional, Marciniak, Wojciech, additional, Durda, Katarzyna, additional, Lener, Marcin, additional, Górski, Bohdan, additional, Cybulski, Cezary, additional, Sukiennicki, Grzegorz, additional, Kaczmarek, Katarzyna, additional, Jaworska-Bieniek, Katarzyna, additional, Paszkowska-Szczur, Katarzyna, additional, Waloszczyk, Piotr, additional, Lubiński, Jan, additional, and Dębniak, Tadeusz, additional

Published
2017
Full Text
View/download PDF

23. Serum Concentrations of Selenium and Copper in Patients Diagnosed with Pancreatic Cancer

Author

Lener, Marcin R., primary, Scott, Rodney J., additional, Wiechowska-Kozłowska, Anna, additional, Serrano-Fernández, Pablo, additional, Baszuk, Piotr, additional, Jaworska-Bieniek, Katarzyna, additional, Sukiennicki, Grzegorz, additional, Marciniak, Wojciech, additional, Muszyńska, Magdalena, additional, Kładny, Józef, additional, Gromowski, Tomasz, additional, Kaczmarek, Katarzyna, additional, Jakubowska, Anna, additional, and Lubiński, Jan, additional

Published
2016
Full Text
View/download PDF

24. Serum concentrations of Cu, Se, Fe and Zn in patients diagnosed with pancreatic cancer

Author

Lener, Marcin, primary, Wiechowska-Kozlowska, Anna, additional, Scott, Rodney J, additional, Muszynska, Magdalena, additional, Kladny, Jozef, additional, Waloszczyk, Piotr, additional, Rutkowska, Anna, additional, Sukiennicki, Grzegorz, additional, Gromowski, Tomasz, additional, Jaworska-Bieniek, Katarzyna, additional, van de Wetering, Thierry, additional, Kaczmarek, Katarzyna, additional, Jakubowska, Anna, additional, and Lubinski, Jan, additional

Published
2015
Full Text
View/download PDF

25. The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men

Author

Antczak, Andrzej, primary, Wokołorczyk, Dominika, additional, Kluźniak, Wojciech, additional, Kashyap, Aniruddh, additional, Jakubowska, Anna, additional, Gronwald, Jacek, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Dębniak, Tadeusz, additional, Masojć, Bartłomiej, additional, Górski, Bohdan, additional, Gromowski, Tomasz, additional, Gołąb, Adam, additional, Sikorski, Andrzej, additional, Słojewski, Marcin, additional, Gliniewicz, Bartłomiej, additional, Borkowski, Tomasz, additional, Borkowski, Andrzej, additional, Przybyła, Jacek, additional, Sosnowski, Marek, additional, Małkiewicz, Bartosz, additional, Zdrojowy, Romuald, additional, Sikorska-Radek, Paulina, additional, Matych, Józef, additional, Wilkosz, Jacek, additional, Różański, Waldemar, additional, Kiś, Jacek, additional, Bar, Krzysztof, additional, Janiszewska, Hanna, additional, Stawicka, Małgorzata, additional, Milecki, Piotr, additional, Lubiński, Jan, additional, Narod, Steven A., additional, and Cybulski, Cezary, additional

Published
2015
Full Text
View/download PDF

26. Lynch syndrome (HNPCC)

Author

Dębniak, Tadeusz, primary, Gromowski, Tomasz, additional, Kładny, Józef, additional, Suchy, Janina, additional, Dymerska, Dagmara, additional, Tutlewska, Katarzyna, additional, Kurzawski, Grzegorz, additional, and Lubiński, Jan, additional

Published
2015
Full Text
View/download PDF

27. Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families

Author

Dębniak, Tadeusz, primary, Gromowski, Tomasz, additional, Scott, Rodney J, additional, Gronwald, Jacek, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Kurzawski, Grzegorz, additional, Dymerska, Dagmara, additional, Górski, Bohdan, additional, Paszkowska-Szczur, Katarzyna, additional, Cybulski, Cezary, additional, Serrano-Fernandez, Pablo, additional, and Lubiński, Jan, additional

Published
2015
Full Text
View/download PDF

28. Review Selenium as a marker of cancer risk and of selection for control examinations in surveillance

Author

Lener, Marcin, primary, Muszyńska, Magdalena, additional, Jakubowska, Anna, additional, Jaworska-Bieniek, Katarzyna, additional, Sukiennicki, Grzegorz, additional, Kaczmarek, Katarzyna, additional, Durda, Katarzyna, additional, Gromowski, Tomasz, additional, Serrano-Fernández, Pablo, additional, Kładny, Józef, additional, Wiechowska-Kozłowska, Anna, additional, Grodzki, Tomasz, additional, Jaworowska, Ewa, additional, Lubiński, Jakub, additional, Górecka-Szyld, Barbara, additional, Wilk, Grażyna, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Cybulski, Cezary, additional, Gronwald, Jacek, additional, Dębniak, Tadeusz, additional, Ashuryk, Olgierd, additional, Tołoczko-Grabarek, Aleksandra, additional, Morawski, Antoni, additional, Scott, Rodney J., additional, and Lubiński, Jan, additional

Published
2015
Full Text
View/download PDF

29. Serum 25(OH)D concentration, common variants of the VDR gene and lung cancer occurrence.

Author

Gromowski, Tomasz, Gapska, Paulina, Scott, Rodney J., Kąklewski, Krzysztof, Marciniak, Wojciech, Durda, Katarzyna, Lener, Marcin, Górski, Bohdan, Cybulski, Cezary, Sukiennicki, Grzegorz, Kaczmarek, Katarzyna, Jaworska‐Bieniek, Katarzyna, Paszkowska‐Szczur, Katarzyna, Waloszczyk, Piotr, Lubiński, Jan, and Dębniak, Tadeusz

Abstract

The first aim of our study was to examine the association between common variants in VDR [rs2228570 ( FokI), rs1544410 ( BsmI), rs7975232 ( ApaI), rs731236 ( TaqI) and rs11568820 ( Cdx2)] and lung cancer risk in the Polish population. Genotyping and statistical analysis which included Chi-square test with Yates correction and haplotype frequency analysis were performed on a series of 840 consecutively collected lung cancer patients and 920 healthy controls. The second aim was to evaluate the link between serum 25(OH)D concentration and the number of lung cancers in a subgroup of 200 patients. A separate control group that consisted of 400 matched (by age, sex, smoking habits and the season of blood collection) healthy individuals was used to avoid posterior adjustment on the matched variables. Statistical analysis with the use of Chi-square test with Yates was performed. We found no statistically significant difference in the distribution of the allels of studied VDR variants among cases and controls. A statistically significant over-representation of VDR haplotypes: rs731236_A + rs1544410_T [odds ratio (OR) = 2.43, 95% confidence interval (CI) = 1.11-5.32, p < 0.001], rs731236_G + rs1544410_T (OR = 1.54, 95% CI = 1.31-1.81, p < 0.001) and rs731236_G + rs1544410_C (OR = 0.04, 95% CI = 0.03-0.07, p < 0.001) was detected. We found a tendency toward an increased number of lung cancers among individuals with low serum levels of 25(OH)D. To answer the question, whether VDR can be regarded as lung cancer susceptibility gene and low 25(OH)D serum levels is associated with lung cancer occurrences, additional, multicenter study needs to be performed. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

30. Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population

Author

Paszkowska-Szczur, Katarzyna, primary, Scott, Rodney J., additional, Górski, Bohdan, additional, Cybulski, Cezary, additional, Kurzawski, Grzegorz, additional, Dymerska, Dagmara, additional, Gupta, Satish, additional, van de Wetering, Thierry, additional, Masojć, Bartłomiej, additional, Kashyap, Aniruddh, additional, Gapska, Paulina, additional, Gromowski, Tomasz, additional, Kładny, Józef, additional, Lubiński, Jan, additional, and Dębniak, Tadeusz, additional

Published
2014
Full Text
View/download PDF

31. Common variants of xeroderma pigmentosum genes and prostate cancer risk

Author

Mirecka, Aneta, primary, Paszkowska-Szczur, Katarzyna, additional, Scott, Rodney J., additional, Górski, Bohdan, additional, van de Wetering, Thierry, additional, Wokołorczyk, Dominika, additional, Gromowski, Tomasz, additional, Serrano-Fernandez, Pablo, additional, Cybulski, Cezary, additional, Kashyap, Aniruddh, additional, Gupta, Satish, additional, Gołąb, Adam, additional, Słojewski, Marcin, additional, Sikorski, Andrzej, additional, Lubiński, Jan, additional, and Dębniak, Tadeusz, additional

Published
2014
Full Text
View/download PDF

32. A common nonsense mutation of the BLM gene and prostate cancer risk and survival

Author

Antczak, Andrzej, primary, Kluźniak, Wojciech, additional, Wokołorczyk, Dominika, additional, Kashyap, Aniruddh, additional, Jakubowska, Anna, additional, Gronwald, Jacek, additional, Huzarski, Tomasz, additional, Byrski, Tomasz, additional, Dębniak, Tadeusz, additional, Masojć, Bartłomiej, additional, Górski, Bohdan, additional, Gromowski, Tomasz, additional, Nagorna, Agnieszka, additional, Gołąb, Adam, additional, Sikorski, Andrzej, additional, Słojewski, Marcin, additional, Gliniewicz, Bartłomiej, additional, Borkowski, Tomasz, additional, Borkowski, Andrzej, additional, Przybyła, Jacek, additional, Sosnowski, Marek, additional, Małkiewicz, Bartosz, additional, Zdrojowy, Romuald, additional, Sikorska-Radek, Paulina, additional, Matych, Józef, additional, Wilkosz, Jacek, additional, Różański, Waldemar, additional, Kiś, Jacek, additional, Bar, Krzysztof, additional, Domagała, Paweł, additional, Stawicka, Małgorzata, additional, Milecki, Piotr, additional, Akbari, Mohammad R., additional, Narod, Steven A., additional, Lubiński, Jan, additional, Cybulski, Cezary, additional, Bryniarski, Piotr, additional, Paradysz, Andrzej, additional, Jersak, Konrad, additional, Niemirowicz, Jerzy, additional, Słupski, Piotr, additional, Jarzemski, Piotr, additional, Skrzypczyk, Michał, additional, Dobruch, Jakub, additional, Domagała, Wenancjusz, additional, Chosia, Maria, additional, van de Wetering, Thierry, additional, Serrano-Fernández, Pablo, additional, Puszyński, Michał, additional, Soczawa, Michał, additional, Świtała, Jerzy, additional, Archimowicz, Sławomir, additional, Kordowski, Mirosław, additional, Życzkowski, Marcin, additional, Borówka, Andrzej, additional, Bagińska, Joanna, additional, Krajka, Kazimierz, additional, Szwiec, Marek, additional, Haus, Olga, additional, Janiszewska, Hanna, additional, Stembalska, Agnieszka, additional, and Sąsiadek, Maria Małgorzata, additional

Published
2013
Full Text
View/download PDF

33. Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population.

Author

Scott, Rodney, Gupta, Satish, Paszkowska-Szczur, Katarzyna, Górski, Bohdan, Cybulski, Cezary, Kurzawski, Grzegorz, Dymerska, Dagmara, Wetering, Thierry, Masojć, Bartłomiej, Kashyap, Aniruddh, Gapska, Paulina, Gromowski, Tomasz, Lubiński, Jan, Dębniak, Tadeusz, and Kładny, Józef

Abstract

Xeroderma pigmentosum (XP) is a rare autosomal recessive disease that is associated with a severe deficiency in nucleotide excision repair. Genetic polymorphisms in XP genes may be associated with a change in DNA repair capacity, which could be associated with colorectal cancer development. We assessed the association between 94 single nucleotide polymorphisms (SNPs) within seven XP genes ( XPA- XPG) and the colorectal cancer risk in the Polish population. We genotyped 758 unselected patients with colorectal cancer and 1,841 healthy adults. We found that a significantly decreased risk of colorectal cancer was associated with XPC polymorphism rs2228000_CT genotype (OR 0.59; p < 0.0001) and the rs2228000_TT genotype (OR 0.29; p < 0.0001) compared to the reference genotype (CC). And an increased disease risk was associated with the XPD SNP, rs1799793_AG genotype (OR 1.44, p = 0.018) and rs1799793_AA genotype (OR 3.31, p < 0.0001) compared to the reference genotype. Haplotype analysis within XPC, XPD and XPG revealed haplotypes associated with an altered colorectal cancer risk. Stratified analysis by gender showed differences between the association of three SNPs: XPC rs2228000, XPD rs1799793 and XPD rs238406 in females and males. Association analysis between age of disease onset and polymorphisms in XPD (rs1799793) and XPC (rs2228000) revealed differences in the prevalence of these variants in patients under and over 50 years of age. Our results confirmed that polymorphisms in XPC and XPD may be associated with the risk of colorectal cancer. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

34. Selenium as a marker of cancer risk and of selection for control examinations in surveillance.

Author

Lener M, Muszyńska M, Jakubowska A, Jaworska-Bieniek K, Sukiennicki G, Kaczmarek K, Durda K, Gromowski T, Serrano-Fernández P, Kładny J, Wiechowska-Kozłowska A, Grodzki T, Jaworowska E, Lubiński J, Górecka-Szyld B, Wilk G, Huzarski T, Byrski T, Cybulski C, Gronwald J, Dębniak T, Ashuryk O, Tołoczko-Grabarek A, Morawski A, Scott RJ, and Lubiński J

Abstract

Publication is summarization of existing data being results of literature review and our experience on usefulness of selenium as a diagnostic marker selection for control examinations in surveillance and as a marker of patients with high risk of cancers.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results