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29 results on '"Groeneveldt, Joanne"'

1. Right Atrial Adaptation to Precapillary Pulmonary Hypertension: Pressure-Volume, Cardiomyocyte, and Histological Analysis

Author

Wessels, Jeroen N., van Wezenbeek, Jessie, de Rover, Jari, Smal, Rowan, Llucià-Valldeperas, Aida, Celant, Lucas R., Marcus, J. Tim, Meijboom, Lilian J., Groeneveldt, Joanne A., Oosterveer, Frank P.T., Winkelman, Toon A., Niessen, Hans W.M., Goumans, Marie-José, Bogaard, Harm Jan, Vonk Noordegraaf, Anton, Strijkers, Gustav J., Handoko, M. Louis, Westerhof, Berend E., and de Man, Frances S.

Published
2023
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6. Distinct Platelet Ribonucleic Acid Signatures in Patients with Pulmonary Hypertension

Author

Smits, A. Josien, primary, Arkani, Mohammad, additional, In ’t Veld, Sjors G.J.G., additional, Huis in ‘t Veld, Anna E., additional, Sol, Nik, additional, Groeneveldt, Joanne A., additional, Botros, Liza, additional, Braams, Natalia J., additional, Jansen, Samara M.A., additional, Ramaker, Jip, additional, Zwaan, Kenn, additional, Post, Edward, additional, Nossent, Esther J., additional, Boonstra, Anco, additional, de Man, Frances S., additional, Noordegraaf, Anton Vonk, additional, Gomez-Arroyo, Jose, additional, Best, Myron G., additional, Wurdinger, Tom, additional, and Bogaard, Harm Jan, additional

Published
2022
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7. Distinct Platelet RNA Signatures in Patients with Pulmonary Hypertension

Author

Smits, A Josien, Arkani, Mohammad, In 't Veld, Sjors G J G, Huis In 't Veld, Anna E, Sol, Nik, Groeneveldt, Joanne A, Botros, Liza, Braams, Natalia J, Jansen, Samara Ma, Ramaker, Jip, Zwaan, Kenn, Post, Edward, Nossent, Esther J, Boonstra, Anco, de Man, Frances S, Vonk Noordegraaf, Anton, Gomez-Arroyo, Jose, Best, Myron G, Wurdinger, Tom, Bogaard, Harm Jan, Pulmonology, and Neurosurgery

Abstract

RATIONALE: Pulmonary hypertension encompasses progressive disorders leading to right ventricular dysfunction and early death. Late detection is an important cause of poor clinical outcomes. However, biomarkers that accurately predict the presence of pulmonary hypertension are currently lacking. OBJECTIVES: In this study we provide evidence that blood platelets contain a distinctive RNA profile that may be exploited for detection of pulmonary hypertension. METHODS: Blood platelet RNA was isolated prospectively from 177 prevalent patients with different subtypes of pulmonary hypertension as well as 195 controls clinically not suspected of pulmonary hypertension. Sequencing libraries were created using SMARTer cDNA amplification, and sequenced on the Illumina HiSeq platform. RNA-sequencing reads were mapped to the human reference genome, and intron-spanning spliced RNA reads were selected. Differential spliced RNA panels were calculated by ANOVA-statistics. A particle swarm optimisation (PSO)-enhanced classification algorithm was built employing a development (n=213 samples) and independent validation series (n=159 samples). RESULTS: We detected a total of 4014 different RNAs in blood platelets from pulmonary hypertension patients (n=177) and asymptomatic controls (n=195). GSEA gene ontology analysis revealed enriched RNA levels for genes related to RNA-processing, translation and mitochondrial function. A PSO-selected RNA panel of 408 distinctive differentially spliced RNAs mediated detection of pulmonary hypertension with 93% sensitivity, 62% specificity, 77% accuracy, 0.89 (95%CI 0.83-0.93) area under the curve and a negative predictive value of 91% in the independent validation series. Prediction score was independent of age, sex, smoking, pulmonary hypertension subtype, and the use of pulmonary hypertension-specific medication or anti-coagulants. CONCLUSION: A platelet RNA-panel may accurately discriminate patients with pulmonary hypertension from asymptomatic controls. In the light of current diagnostic delays, this study is the starting point for further development and evaluation of a platelet RNA-based blood test, to ultimately improve early diagnosis and clinical outcomes in patients with pulmonary hypertension.

Published
2022

8. When right ventricular pressure meets volume: The impact of arrival time of reflected waves on right ventricle load in pulmonary arterial hypertension

Author

Fukumitsu, Masafumi, primary, Groeneveldt, Joanne A., additional, Braams, Natalia J., additional, Bayoumy, Ahmed A., additional, Marcus, J. Tim, additional, Meijboom, Lilian J., additional, de Man, Frances S., additional, Bogaard, Harm‐Jan, additional, Vonk Noordegraaf, Anton, additional, and Westerhof, Berend E., additional

Published
2022
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9. Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort

Author

van Wezenbeek, Jessie, primary, Groeneveldt, Joanne A., additional, Llucià-Valldeperas, Aida, additional, van der Bruggen, Cathelijne E., additional, Jansen, Samara M.A., additional, Smits, A. Josien, additional, Smal, Rowan, additional, van Leeuwen, Joost W., additional, Remedios, Cris dos, additional, Keogh, Anne, additional, Humbert, Marc, additional, Dorfmüller, Peter, additional, Mercier, Olaf, additional, Guignabert, Christophe, additional, Niessen, Hans W.M., additional, Handoko, M. Louis, additional, Marcus, J. Tim, additional, Meijboom, Lilian J., additional, Oosterveer, Frank P.T., additional, Westerhof, Berend E., additional, Heijboer, Annemieke C., additional, Bogaard, Harm Jan, additional, Vonk Noordegraaf, Anton, additional, Goumans, Marie José, additional, and de Man, Frances S., additional

Published
2022
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11. Abstract 10462: Increased Bone Morphogenetic Protein 10 Activity is Associated with Increased Right Atrial Wall Stress and Disease Severity in Pulmonary Hypertension

Author

Llucià-Valldeperas, Aida, primary, Van Wezenbeek, Jessie, additional, Groeneveldt, Joanne A, additional, Sanchez-Duffhues, Gonzalo, additional, Smal, Rowan, additional, Pan, Xiaoke, additional, vonk noordegraaf, anton, additional, Bogaard, Harm J, additional, Goumans, Marie Jose, additional, and De Man, Frances S, additional

Published
2021
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12. sj-pdf-1-pul-10.1177_2045894019873548 - Supplemental material for Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients

Author

Rijnierse, Mischa T., Groeneveldt, Joanne A., Campen, Jasmijn S.J.A. Van, Boer, Karin De, Bruggen, Cathelijne E.E. Van Der, Harms, Hendrik J., Raijmakers, Pieter G., Lammertsma, Adriaan A., Knaapen, Paul, Bogaard, Harm Jan, Westerhof, Berend E., Noordegraaf, Anton Vonk, Allaart, Cornelis P., and Man, Frances S. De

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology
Abstract

Supplemental material, sj-pdf-1-pul-10.1177_2045894019873548 for Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients by Mischa T. Rijnierse, Joanne A. Groeneveldt, Jasmijn S.J.A. van Campen, Karin de Boer, Cathelijne E.E. van der Bruggen, Hendrik J. Harms, Pieter G. Raijmakers, Adriaan A. Lammertsma, Paul Knaapen, Harm Jan Bogaard, Berend E. Westerhof, Anton Vonk Noordegraaf, Cornelis P. Allaart and Frances S. de Man in Pulmonary Circulation

Published
2020
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13. sj-pdf-3-pul-10.1177_2045894019873548 - Supplemental material for Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients

Author

Rijnierse, Mischa T., Groeneveldt, Joanne A., Campen, Jasmijn S.J.A. Van, Boer, Karin De, Bruggen, Cathelijne E.E. Van Der, Harms, Hendrik J., Raijmakers, Pieter G., Lammertsma, Adriaan A., Knaapen, Paul, Bogaard, Harm Jan, Westerhof, Berend E., Noordegraaf, Anton Vonk, Allaart, Cornelis P., and Man, Frances S. De

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology
Abstract

Supplemental material, sj-pdf-3-pul-10.1177_2045894019873548 for Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients by Mischa T. Rijnierse, Joanne A. Groeneveldt, Jasmijn S.J.A. van Campen, Karin de Boer, Cathelijne E.E. van der Bruggen, Hendrik J. Harms, Pieter G. Raijmakers, Adriaan A. Lammertsma, Paul Knaapen, Harm Jan Bogaard, Berend E. Westerhof, Anton Vonk Noordegraaf, Cornelis P. Allaart and Frances S. de Man in Pulmonary Circulation

Published
2020
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14. sj-pdf-2-pul-10.1177_2045894019873548 - Supplemental material for Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients

Author

Rijnierse, Mischa T., Groeneveldt, Joanne A., Campen, Jasmijn S.J.A. Van, Boer, Karin De, Bruggen, Cathelijne E.E. Van Der, Harms, Hendrik J., Raijmakers, Pieter G., Lammertsma, Adriaan A., Knaapen, Paul, Bogaard, Harm Jan, Westerhof, Berend E., Noordegraaf, Anton Vonk, Allaart, Cornelis P., and Man, Frances S. De

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology
Abstract

Supplemental material, sj-pdf-2-pul-10.1177_2045894019873548 for Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients by Mischa T. Rijnierse, Joanne A. Groeneveldt, Jasmijn S.J.A. van Campen, Karin de Boer, Cathelijne E.E. van der Bruggen, Hendrik J. Harms, Pieter G. Raijmakers, Adriaan A. Lammertsma, Paul Knaapen, Harm Jan Bogaard, Berend E. Westerhof, Anton Vonk Noordegraaf, Cornelis P. Allaart and Frances S. de Man in Pulmonary Circulation

Published
2020
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15. Early return of reflected waves increases right ventricular wall stress in chronic thromboembolic pulmonary hypertension

Author

Fukumitsu, Masafumi, primary, Westerhof, Berend E., additional, Ruigrok, Dieuwertje, additional, Braams, Natalia J., additional, Groeneveldt, Joanne A., additional, Bayoumy, Ahmed A., additional, Marcus, J. Tim, additional, Meijboom, Lilian J., additional, de Man, Frances S., additional, Westerhof, Nico, additional, Bogaard, Harm-Jan, additional, and Vonk Noordegraaf, Anton, additional

Published
2020
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17. Determinants of right ventricular diastolic stiffness in precapillary pulmonary hypertension: a cardiac magnetic resonance study

Author

Bayoumy, Ahmed A., primary, Braams, Natalia J., additional, Mouratoglou, Sophia A., additional, Spruijt, Onno A., additional, De Man, Frances S., additional, Vonk-Noordegraaf, Anton, additional, Jansen, Samara M.A., additional, Groeneveldt, Joanne A., additional, Westerhof, Berend E., additional, Marcus, J. Tim, additional, Meijboom, Lilian J., additional, and Bogaard, Harm-Jan, additional

Published
2020
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19. Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients

Author

Rijnierse, Mischa T., primary, Groeneveldt, Joanne A., additional, van Campen, Jasmijn S.J.A., additional, Boer, Karin de, additional, van der Bruggen, Cathelijne E.E., additional, Harms, Hendrik J., additional, Raijmakers, Pieter G., additional, Lammertsma, Adriaan A., additional, Knaapen, Paul, additional, Bogaard, Harm Jan, additional, Westerhof, Berend E., additional, Noordegraaf, Anton Vonk, additional, Allaart, Cornelis P., additional, and de Man, Frances S., additional

Published
2020
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20. Differences of right ventricular diastolic stiffness in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Author

Bayoumy, Ahmed A., primary, J. Braams, Natalia, additional, A. Spruijt, Onno, additional, S. De Man, Frances, additional, A. Groeneveldt, Joanne, additional, Vonk-Noordegraaf, Anton, additional, E. Westerhof, Berend, additional, Tim Marcus, J., additional, J. Meijboom, Lilian, additional, M. A. Jansen, S.M.A., additional, and Bogaard, Harm-Jan, additional

Published
2019
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23. Bisoprolol therapy does not reduce right ventricular sympathetic activity in pulmonary arterial hypertension patients

Author

Rijnierse, Mischa T., Groeneveldt, Joanne A., van Campen, Jasmijn S.J.A., Boer, Karin de, van der Bruggen, Cathelijne E.E., Harms, Hendrik J., Raijmakers, Pieter G., Lammertsma, Adriaan A., Knaapen, Paul, Bogaard, Harm Jan, Westerhof, Berend E., Noordegraaf, Anton Vonk, Allaart, Cornelis P., and de Man, Frances S.

Abstract

Right ventricular (RV) function and autonomic dysfunction are important determinants of morbidity and mortality in patients with pulmonary arterial hypertension (PAH). Although successful in animal studies, effects of beta-blocker therapy on RV function in clinical trials were disappointing. To understand this discrepancy, we studied whether beta-blocker therapy changes RV sympathetic activity. Idiopathic PAH (IPAH) patients received beta-blocker therapy (uptitrated to a maximal tolerated dose) and underwent cardiac magnetic resonance imaging, right heart catheterization, and a [11C]-hydroxyephedrine positron emission tomography ([11C]HED PET) scan at baseline to determine, respectively, RV ejection fraction (RVEF), RV pressures, and sympathetic activity. [11C]HED, a norepinephrine analogue, allows determination of sympathetic innervation of the RV. [11C]HED retention index reflects norepinephrine transporter activity. As a consequence of excessive catecholamine levels in the synaptic cleft, this transporter may be downregulated. Therefore, low [11C]HED retention index indicates high sympathetic activity. 13 IPAH patients underwent [11C]HED PET scans at baseline and after bisoprolol treatment. Although heart rate was reduced, systemic modulation of autonomic activity by bisoprolol did not affect local RV sympathetic nerve activity, RV function, or RV wall tension. In PAH patients, RV [11C]HED retention index was lower compared to LV tracer uptake (p<0.01) and was related to systolic wall tension (R2= 0.4731, p<0.01) and RV function (R2= 0.44, p = 0.01). In RV failure, the tolerated dosage of bisoprolol did not result in an improvement of RV function nor in a reduction in RV sympathetic activity.

Published
2024
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27. Preserving right ventricular function in patients with pulmonary arterial hypertension: Single centre experience with a cardiac magnetic resonance imaging-guided treatment strategy

Author

Huis in ’t Veld, Anna E., Van de Veerdonk, Mariëlle C., Spruijt, Onno A., Groeneveldt, Joanne A., Marcus, J. Tim, Westerhof, Nico, Jan Bogaard, Harm, and Noordegraaf, Anton Vonk

Abstract

The feasibility and usefulness of routine cardiac magnetic resonance imaging (CMR) in the management of idiopathic pulmonary arterial hypertension (IPAH) is unknown. The aims of the study were: 1) to study whether a decrease in CMR-derived right ventricular ejection fraction (RVEF) coincides with clinical deterioration; 2) to determine whether RVEF is responsive to early escalation of pulmonary arterial hypertension (PAH)-specific therapy. This was a prospective study including 30 incident IPAH patients. Patients underwent right heart catheterization and CMR at regular follow-up visits (baseline, four, eight, 12, 24 months; no right heart catheterization at eight months). New York Heart Association (NYHA) functional class II patients started with monotherapy (endothelin receptor antagonist or phosphodiesterase-5-inhibitor) and NYHA III patients with combination therapy (endothelin receptor antagonist plus phosphodiesterase-5-inhibitor). In the case of a deterioration in RVEF of more than 3% compared with the previous measurement, PAH-specific therapy was added (i.e. treatment escalation). In 11 patients without signs of clinical deterioration, a greater than 3% decrease in RVEF occurred. After treatment escalation, RVEF significantly improved (average improvement of 7%, p= 0.009) whereas right ventricle volumes, N-terminal pro-brain natriuretic peptide and six-minute walking distance remained stable. Clinical worsening did not occur after escalating therapy. Throughout the study, four patients presented with clinical worsening, despite a stable RVEF. Three of these four patients had a baseline RVEF <35%. In IPAH patients presenting with an early decrease in RVEF but otherwise stable disease, progressive right ventricle failure and subsequent clinical worsening did not occur when therapy was escalated. Nevertheless, clinical worsening did occur in patients with a low baseline RVEF.

Published
2018
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28. Early return of reflected waves increases right ventricular wall stress in chronic thromboembolic pulmonary hypertension.

Author

Fukumitsu M, Westerhof BE, Ruigrok D, Braams NJ, Groeneveldt JA, Bayoumy AA, Marcus JT, Meijboom LJ, de Man FS, Westerhof N, Bogaard HJ, and Vonk Noordegraaf A

Subjects
Aged, Catheterization, Swan-Ganz, Chronic Disease, Female, Humans, Hypertension, Pulmonary diagnosis, Hypertension, Pulmonary physiopathology, Hypertrophy, Right Ventricular diagnostic imaging, Hypertrophy, Right Ventricular physiopathology, Magnetic Resonance Imaging, Male, Middle Aged, Pulmonary Embolism diagnosis, Pulmonary Embolism physiopathology, Retrospective Studies, Stroke Volume, Time Factors, Vascular Resistance, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right physiopathology, Ventricular Remodeling, Arterial Pressure, Hypertension, Pulmonary etiology, Hypertrophy, Right Ventricular etiology, Pulmonary Artery physiopathology, Pulmonary Embolism complications, Ventricular Dysfunction, Right etiology, Ventricular Function, Right
Abstract

Pulmonary vascular resistance (PVR) and compliance are comparable in proximal and distal chronic thromboembolic pulmonary hypertension (CTEPH). However, proximal CTEPH is associated with inferior right ventricular (RV) adaptation. Early wave reflection in proximal CTEPH may be responsible for altered RV function. The aims of the study are as follows: 1 ) to investigate whether reflected pressure returns sooner in proximal than in distal CTEPH and 2 ) to elucidate whether the timing of reflected pressure is related to RV dimensions, ejection fraction (RVEF), hypertrophy, and wall stress. Right heart catheterization and cardiac MRI were performed in 17 patients with proximal CTEPH and 17 patients with distal CTEPH. In addition to the determination of PVR, compliance, and characteristic impedance, wave separation analysis was performed to determine the magnitude and timing of the peak reflected pressure (as %systole). Findings were related to RV dimensions and time-resolved RV wall stress. Proximal CTEPH was characterized by higher RV volumes, mass, and wall stress, and lower RVEF. While PVR, compliance, and characteristic impedance were similar, proximal CTEPH was related to an earlier return of reflected pressure than distal CTEPH (proximal 53 ± 8% vs. distal 63 ± 15%, P < 0.05). The magnitude of the reflected pressure waves did not differ. RV volumes, RVEF, RV mass, and wall stress were all related to the timing of peak reflected pressure. Poor RV function in patients with proximal CTEPH is related to an early return of reflected pressure wave. PVR, compliance, and characteristic impedance do not explain the differences in RV function between proximal and distal CTEPH. NEW & NOTEWORTHY In chronic thromboembolic pulmonary hypertension (CTEPH), proximal localization of vessel obstructions is associated with poor right ventricular (RV) function compared with distal localization, though pulmonary vascular resistance, vascular compliance, characteristic impedance, and the magnitude of wave reflection are similar. In proximal CTEPH, the RV is exposed to an earlier return of the reflected wave. Early wave reflection may increase RV wall stress and compromise RV function.

Published
2020
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