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Space analog research has increased over the last few years with new analogs appearing every year. Research in this field is very important for future real mission planning, selection and training of astronauts. Analog environments offer specific characteristics that resemble to some extent the environment of a real space mission. These analog environments are especially interesting from the psychological point of view since they allow the investigation of mental and social variables in very similar conditions to those occurring during real space missions. Analog missions also represent an opportunity to test operational work and obtain information on which combination of processes and team dynamics are most optimal for completing specific aspects of the mission. A group of experts from a European Space Agency (ESA) funded topical team reviews the current situation of topic, potentialities, gaps, and recommendations for appropriate research. This review covers the different domains in space analog research including classification, main areas of behavioral health performance research in these environments and operational aspects. We also include at the end, a section with a list or tool of recommendations in the form of a checklist for the scientific community interested in doing research in this field. This checklist can be useful to maintain optimal standards of methodological and scientific quality, in addition to identifying topics and areas of special interest., (© 2024. The Author(s).)

Surgical resection remains the gold standard of treatment for early-stage lung cancer. Several risk models exist to predict postoperative morbidity and mortality. Psoas muscle sarcopenia has already successfully been used for morbidity prediction in lung transplantation and is not yet included in the available risk scores for pulmonary resections. We hypothesized that the skeletal muscle index and mediastinal adipose tissue might also have an impact on postoperative outcomes after primary surgery for primary lung cancer. The institutional database was queried for patients with primary lung cancer who were treated with primary lobectomy or segmentectomy between February 2009 and November 2018. In total, 311 patients were included for analysis. Patients receiving neo-/adjuvant chemotherapy or with a positive nodal status were excluded to rule out any morbidity or mortality due to (neo-)adjuvant treatment. Sarcopenia was defined as a skeletal muscle index of <34.4 cm 2 /m 2 for women and <45.4 cm 2 /m 2 for men. Mediastinal adipose tissue was defined with a radiodensity of -150 to -30 Hounsfield units. Sarcopenia was diagnosed in 78 (25.1%) of the 311 patients. Male patients were significantly more likely to suffer from sarcopenia (31.5% vs. 18.1%, p = 0.009). Comorbidities, lung function, tumour histology, pathologic tumour staging, mediastinal adipose tissue and age did not differ between groups with or without sarcopenia. Sarcopenic patients had a significantly longer length of stay, with 13.0 days vs. 9.5 ( p = 0.003), and a higher rate of any postoperative complications (59.0% vs. 44.6%, p = 0.036). There was no difference in recurrence rate. Five-year overall survival was significantly better in the patient cohort without sarcopenia (75.6% vs. 64.5%, p = 0.044). Mediastinal adipose tissue showed no significant impact on length of stay, postoperative complications, recurrence rate, morbidity or survival. Sarcopenia, quantified with the skeletal muscle index, is shown to be a risk factor for postoperative morbidity and reduced survival in primary lung cancer. Efforts should be taken to pre-emptively screen for sarcopenia and start countermeasures (e.g., physical prehabilitation, protein-rich nutrition, etc.) during the preoperative workup phase.

One of the primary objectives of planetary exploration is the search for signs of life (past, present, or future). Formulating an understanding of the geochemical processes on planetary bodies may allow us to define the precursors for biological processes, thus providing insight into the evolution of past life on Earth and other planets, and perhaps a projection into future biological processes. Several techniques have emerged for detecting biomarker signals on an atomic or molecular level, including laser-induced breakdown spectroscopy (LIBS), Raman spectroscopy, laser-induced fluorescence (LIF) spectroscopy, and attenuated total reflectance Fourier transform infrared (ATR FT-IR) spectroscopy, each of which addresses complementary aspects of the elemental composition, mineralogy, and organic characterization of a sample. However, given the technical challenges inherent to planetary exploration, having a sound understanding of the data provided from these technologies, and how the inferred insights may be used synergistically is critical for mission success. In this work, we present an in-depth characterization of a set of samples collected during a 28-day Mars analog mission conducted by the Austrian Space Forum in the Dhofar region of Oman. The samples were obtained under high-fidelity spaceflight conditions and by considering the geological context of the test site. The specimens were analyzed using the LIBS-Raman sensor, a prototype instrument for future exploration of Mars. We present the elemental quantification of the samples obtained from LIBS using a previously developed linear mixture model and validated using scanning electron microscopy energy dispersive spectroscopy. Moreover, we provide a full mineral characterization obtained using ultraviolet Raman spectroscopy and LIF, which was verified through ATR FT-IR. Lastly, we present possible discrimination of organics in the samples using LIF and time-resolved LIF. Each of these methods yields accurate results, with low errors in their predictive capabilities of LIBS (median relative error ranging from 4.5% to 16.2%), and degree of richness in subsequent inferences to geochemical and potential biochemical processes of the samples. The existence of such methods of inference and our ability to understand the limitations thereof is crucial for future planetary missions, not only to Mars and Moon but also for future exoplanetary exploration.

Analog research of human or combined human and robotic missions is an established tool to explore the workflows, instruments, risks, and challenges of future planetary surface missions in a representative terrestrial environment. Analog missions that emulate selected aspects of such expeditions have risen in number, expanded their range of disciplines covered, and seen a significant increase in their operational and programmatic impact on mission planning. We propose a method to compare analog missions across agencies, disciplines, and complexities/fidelities to improve scientific output and mission safety and maximize effectiveness and efficiency. This algorithm measures mission performance, provides a tool for an objective postmission evaluation, and catalyzes programmatic progress. It does not evaluate individual sites or instruments but focuses at mission level. By applying the algorithm to several missions, we compare the missions' performance for benchmarking purposes. Methodically, a combination of objective data sets and questionnaires is used to evaluate three areas: two sections of closed and quantitative questions and a third section dedicated to the level or representativeness of the test site. By using a weighted metric, the complexity and fidelity of a mission are compared with reference missions, which yield strengths and weaknesses in mission planning.

Between February 1 and 28, 2018, the Austrian Space Forum, in cooperation with the Oman Astronomical Society and research teams from 25 nations, conducted the AMADEE-18 mission, a human-robotic Mars expedition simulation in the Dhofar region in the Sultanate of Oman. As a part of the AMADEE-18 simulated Mars human exploration mission, the Remote Science Support team performed analyses of the Dhofar area (Oman) in an effort to characterize the region as a potential Mars analog site. The main motivation of this research was to study and register selected samples collected by analog astronauts during the AMADEE-18 mission with laboratory analytical methods and techniques comparable with those that are likely to be used on Mars in the future. The 25 samples representing unconsolidated sediments obtained during the simulated mission were studied by using optical microscopy, Raman spectroscopy, X-ray diffraction, laser-induced breakdown spectroscopy, and laser-induced fluorescence spectroscopy. The principal results show the existence of minerals and alteration processes related to volcanism, hydrothermalism, and weathering. The analogy between the Dhofar region and the Eridana Basin region of Mars is clearly noticeable, particularly as an analog for secondary minerals formed in a hydrothermal seafloor volcanic-sedimentary environment. The synergy between the techniques used in the present work provides a solid basis for the geochemical analyses and organic detection in the context of future human-robotic Mars expeditions. AMADEE-18 has been a prime test bed for geoscientific workflows with astrobiological relevance and has provided valuable insights for future space missions.

From February 1 to 28, 2018, the Austrian Space Forum, in cooperation with the Oman Astronomical Society and research teams from 25 nations, conducted the AMADEE-18 mission, a human-robotic Mars expedition simulation in the Dhofar region in the Sultanate of Oman. A carefully selected field crew, supported by a Mission Support Center in Innsbruck, Austria, conducted 19 experiments relevant to astrobiology, engineering disciplines, geoscience, operations research, and human factors. This expedition was the 12th in a series of analog missions that emulate selected aspects of the science expected for a human Mars mission, including the characterization of the (paleo)geological environment, human factors studies, and the search for biomarkers. In particular, an Exploration Cascade was deployed as a suggested workflow for coordinating the timing and location of the respective instruments and experiments. In validation of this workflow, the decision-making interaction between the field and the Mission Support Center was studied. This article introduces the AMADEE-18 mission and provides the mission-specific context for the other contributions of this special issue.

We report on the MARS2013 mission, a 4-week Mars analog field test in the northern Sahara. Nineteen experiments were conducted by a field crew in Morocco under simulated martian surface exploration conditions, supervised by a Mission Support Center in Innsbruck, Austria. A Remote Science Support team analyzed field data in near real time, providing planning input for the management of a complex system of field assets; two advanced space suit simulators, four robotic vehicles, an emergency shelter, and a stationary sensor platform in a realistic work flow were coordinated by a Flight Control Team. A dedicated flight planning group, external control centers for rover tele-operations, and a biomedical monitoring team supported the field operations. A 10 min satellite communication delay and other limitations pertinent to human planetary surface activities were introduced. The fields of research for the experiments were geology, human factors, astrobiology, robotics, tele-science, exploration, and operations research. This paper provides an overview of the geological context and environmental conditions of the test site and the mission architecture, in particular the communication infrastructure emulating the signal travel time between Earth and Mars. We report on the operational work flows and the experiments conducted, including a deployable shelter prototype for multiple-day extravehicular activities and contingency situations.

Abstract We have developed a portable dual-wavelength laser fluorescence spectrometer as part of a multi-instrument optical probe to characterize mineral, organic, and microbial species in extreme environments. Operating at 405 and 532 nm, the instrument was originally designed for use by human explorers to produce a laser-induced fluorescence emission (L.I.F.E.) spectral database of the mineral and organic molecules found in the microbial communities of Earth's cryosphere. Recently, our team had the opportunity to explore the strengths and limitations of the instrument when it was deployed on a remote-controlled Mars analog rover. In February 2013, the instrument was deployed on board the Magma White rover platform during the MARS2013 Mars analog field mission in the Kess Kess formation near Erfoud, Morocco. During these tests, we followed tele-science work flows pertinent to Mars surface missions in a simulated spaceflight environment. We report on the L.I.F.E. instrument setup, data processing, and performance during field trials. A pilot postmission laboratory analysis determined that rock samples acquired during the field mission exhibited a fluorescence signal from the Sun-exposed side characteristic of chlorophyll a following excitation at 405 nm. A weak fluorescence response to excitation at 532 nm may have originated from another microbial photosynthetic pigment, phycoerythrin, but final assignment awaits development of a comprehensive database of mineral and organic fluorescence spectra. No chlorophyll fluorescence signal was detected from the shaded underside of the samples.

Martian caves are regarded as one of the most interesting locations in which to search for life on the planet. Data obtained during the MARS2013 expedition at Hamar Laghdad Ridge in the Tafilalt region of Morocco indicate that even small cavities can display thermal behavior that is characteristic for caves. For example, temperature in a cavity equaled 14°C±0.1°C before sunrise, which was higher than the temperature of the ambient air (10°C±0.1°C) and proximate rocks (9°C±0.1°C) at the same time. Within 30 min after sunrise, when the temperature of surrounding rocks corresponded to 15°C, this thermal relationship reversed. Measurements were conducted under simulated spaceflight conditions, including near-real-time interpretation of data that were acquired in a complex flight planning environment. We conclude that using ground-based thermal contrast measurements, in 7-14 μm band before and after sunset, is an effective method for Mars astronauts to identify caves, possibly superior to usage of space-based or ground-penetrating data.

MARS2013 was an integrated Mars analog field simulation in eastern Morocco performed by the Austrian Space Forum between February 1 and 28, 2013. The purpose of this paper is to discuss the system of data processing and utilization adopted by the Remote Science Support (RSS) team during this mission. The RSS team procedures were designed to optimize operational efficiency of the Flightplan, field crew, and RSS teams during a long-term analog mission with an introduced 10 min time delay in communication between "Mars" and Earth. The RSS workflow was centered on a single-file, easy-to-use, spatially referenced database that included all the basic information about the conditions at the site of study, as well as all previous and planned activities. This database was prepared in Google Earth software. The lessons learned from MARS2013 RSS team operations are as follows: (1) using a spatially referenced database is an efficient way of data processing and data utilization in a long-term analog mission with a large amount of data to be handled, (2) mission planning based on iterations can be efficiently supported by preparing suitability maps, (3) the process of designing cartographical products should start early in the planning stages of a mission and involve representatives of all teams, (4) all team members should be trained in usage of cartographical products, (5) technical problems (e.g., usage of a geological map while wearing a space suit) should be taken into account when planning a work flow for geological exploration, (6) a system that helps the astronauts to efficiently orient themselves in the field should be designed as part of future analog studies.