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602 results on '"Grodin, Justin L."'

6. The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology

Author

STERN, LILY K., GRODIN, JUSTIN L., MAURER, MATHEW S., RUBERG, FREDERICK L., PATEL, AYAN R., KHOURI, MICHEL G., ROTH, LORI R., ARAS, MANDAR A., BHARDWAJ, ANJU, BHATTACHARYA, PRIYANKA, BRAILOVSKY, YEVGENIY, DRACHMAN, BRIAN M., EBONG, IMO A., FINE, NOWELL M., GAGGIN, HANNA, GOPAL, DEEPA, GRIFFIN, JAN, JUDGE, DANIEL, KIM, PAUL, MITCHELL, JOSHUA, MITTER, SUMEET S., MOHAN, RAJEEV C., RAMOS, HANNIA, REYENTOVICH, ALEX, SHEIKH, FAROOQ H., SPERRY, BRETT, CARTER, SPENCER, UREY, MARCUS, VAISHNAV, JOBAN, VEST, AMANDA R., KITTLESON, MICHELLE M., and PATEL, JIGNESH K.

Published
2024
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17. Amyloidosis and 30-Day Outcomes Among Patients With Heart Failure: A Nationwide Readmissions Database Study.

Author

Arora, Sameer, Patil, Nikita S, Strassle, Paula D, Qamar, Arman, Vaduganathan, Muthiah, Fatima, Amber, Mogili, Kalyan, Garipalli, Deepak, Grodin, Justin L, Vavalle, John P, Fonarow, Gregg C, Bhatt, Deepak L, and Pandey, Ambarish

Subjects
ATTR, transthyretin amyloidosis, CCI, Charlson comorbidity index, CI, confidence interval, CV, cardiovascular, HF, heart failure, ICD-9-CM, International Classification of Diseases-9th Revision-Clinical Modification, LOS, length of stay, NRD, Nationwide Readmissions Database, OR, odds ratio, amyloidosis, heart failure, mortality, readmissions, Aging, Heart Disease, Cardiovascular, Clinical Research
Abstract

BackgroundThe burden of amyloidosis among hospitalized patients is increasing over time. However, amyloidosis remains an underdiagnosed cause of heart failure (HF) hospitalization among older adults.ObjectivesWe investigated the prevalence and prognostic implications of amyloidosis among patients hospitalized with HF.MethodsAll hospitalizations for primary diagnosis of HF between January 1, 2010, and August 31, 2015, identified in the Nationwide Readmissions Database were categorized into those with and without a secondary diagnosis of amyloidosis. HF hospitalizations with amyloidosis were then matched in a 3:1 fashion to HF hospitalizations without amyloidosis using the year of admission, discharge quarter, age, sex, and Charlson comorbidity index. Primary outcomes were inpatient mortality and 30-day readmission. Multivariable logistic regression was used to estimate the association between HF with amyloidosis and clinical outcomes.ResultsOf 1,593,360 HF hospitalizations that met inclusion criteria, 2,846 (0.18%) had HF with a secondary diagnosis of amyloidosis and were matched to 8,515 hospitalizations for HF without amyloidosis. Hospitalizations for HF with amyloidosis were associated with higher prevalence of kidney disease (56% vs. 45%), malignancy (20% vs. 4%), and higher inpatient mortality (6% vs. 3%) as compared with HF without amyloidosis. In adjusted analyses, HF with amyloidosis was associated with higher odds of in-hospital mortality (odds ratio: 1.46; 95% confidence interval [CI]: 1.17 to 1.82), 30-day readmission (odds ratio: 1.17; 95% CI: 1.05 to 1.31), and longer mean length of stay (least-squares mean difference: 1.46; 95% CI: 1.12 to 1.80).ConclusionsIn patients hospitalized with decompensated HF, presence of amyloidosis was associated with higher risk of inpatient mortality and 30-day readmission.

Published
2020

18. Association of Long-term Change and Variability in Glycemia With Risk of Incident Heart Failure Among Patients With Type 2 Diabetes: A Secondary Analysis of the ACCORD Trial

Author

Segar, Matthew W, Patel, Kershaw V, Vaduganathan, Muthiah, Caughey, Melissa C, Butler, Javed, Fonarow, Gregg C, Grodin, Justin L, McGuire, Darren K, and Pandey, Ambarish

Subjects
Heart Disease, Prevention, Diabetes, Clinical Research, Cardiovascular, Metabolic and endocrine, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Follow-Up Studies, Glycated Hemoglobin, Glycemic Control, Heart Failure, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Risk Factors, Time Factors
Abstract

ObjectiveTo evaluate the associations between long-term change and variability in glycemia with risk of heart failure (HF) among patients with type 2 diabetes mellitus (T2DM).Research design and methodsAmong participants with T2DM enrolled in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, variability in HbA1c was assessed from stabilization of HbA1c following enrollment (8 months) to 3 years of follow-up as follows: average successive variability (ASV) (average absolute difference between successive values), coefficient of variation (SD/mean), and SD. Participants with HF at baseline or within 3 years of enrollment were excluded. Adjusted Cox models were used to evaluate the association of percent change (from baseline to 3 years of follow-up) and variability in HbA1c over the first 3 years of enrollment and subsequent risk of HF.ResultsThe study included 8,576 patients. Over a median follow-up of 6.4 years from the end of variability measurements at year 3, 388 patients had an incident HF hospitalization. Substantial changes in HbA1c were significantly associated with higher risk of HF (hazard ratio [HR] for ≥10% decrease 1.32 [95% CI 1.08-1.75] and for ≥10% increase 1.55 [1.19-2.04]; reference

Published
2020

19. Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score

Author

Segar, Matthew W, Vaduganathan, Muthiah, Patel, Kershaw V, McGuire, Darren K, Butler, Javed, Fonarow, Gregg C, Basit, Mujeeb, Kannan, Vaishnavi, Grodin, Justin L, Everett, Brendan, Willett, Duwayne, Berry, Jarett, and Pandey, Ambarish

Subjects
Heart Disease, Patient Safety, Nutrition, Prevention, Cardiovascular, Clinical Research, Diabetes, Metabolic and endocrine, Aged, Clinical Trials as Topic, Cohort Studies, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Heart Failure, Hospitalization, Humans, Incidence, Machine Learning, Male, Middle Aged, Outpatients, Predictive Value of Tests, Reproducibility of Results, Risk Assessment, Risk Factors, Time Factors
Abstract

ObjectiveTo develop and validate a novel, machine learning-derived model to predict the risk of heart failure (HF) among patients with type 2 diabetes mellitus (T2DM).Research design and methodsUsing data from 8,756 patients free at baseline of HF, with

Published
2019

25. Identifying a low‐flow phenotype in heart failure with preserved ejection fraction: a secondary analysis of the RELAX trial

Author

Patel, Kershaw V, Mauricio, Rina, Grodin, Justin L, Ayers, Colby, Fonarow, Gregg C, Berry, Jarett D, and Pandey, Ambarish

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Heart Disease, Clinical Research, Clinical Trials and Supportive Activities, Aged, Exercise Tolerance, Female, Heart Failure, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Phenotype, Stroke Volume, Heart failure with preserved ejection fraction, Stroke volume, Fitness, Biomarkers, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

AimsThe relationship between resting stroke volume (SV) and prognostic markers in heart failure with preserved ejection fraction (HFpEF) is not well established. We evaluated the association of SV index (SVI) at rest with exercise capacity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in stable patients with HFpEF.Methods and resultsParticipants enrolled in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (RELAX) trial with available data on SVI by the Doppler method were included in this analysis (n = 185). A low-flow state defined by resting SVI

Published
2019

31. Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population

Author

Hendren, Nicholas S., primary, De Lemos, James A., additional, Berry, Jarett D., additional, Kozlitina, Julia, additional, Saelices, Lorena, additional, Ji, Alan X., additional, Shao, Zhili, additional, Liu, Chia-Feng, additional, Garg, Sonia, additional, Farr, Maryjane A., additional, Drazner, Mark H., additional, Tang, W. H. Wilson, additional, and Grodin, Justin L., additional

Published
2024
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32. Malignancy After Transplant

Author

Cheeran, Daniel, Morlend, Robert M., Grodin, Justin L., Doria, Cataldo, Series Editor, Bogar, Linda, editor, and Stempien-Otero, April, editor

Published
2020
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45. Effective medications can work only in patients who take them: implications for post acute heart failure care

Author

Cotter, Gad, primary, Davison, Beth A., additional, Adams, Kirkwood F., additional, Ambrosy, Andrew P., additional, Atabaeva, Lina, additional, Beavers, Craig J, additional, Bhatt, Ankeet S., additional, Givertz, Michael M., additional, Grodin, Justin L., additional, Lala, Anuradha, additional, Novosadov, Mikhail, additional, Sokos, George G., additional, Takagi, Koji, additional, Teerlink, John R., additional, and Bhatt, Deepak L., additional

Published
2023
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