1. Klinisch beloop van covid-19 in Nederland
- Author
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Marcel Aries, Joop van den Bergh, Martijn Beudel, Wim Boersma, Tom Dormans, Douma, Renee A., Annet Eerens, Elbers, Paul W. G., Fleuren, Lucas M., Gritters Den Oever, Niels C., Lianne de Haan, Horst, Iwan C. C., Shi Hu, Deborah Hubers, Mark Janssen, Martijn de Kruif, Pieter Kubben, Sander van Kuijk, Noordzij, Peter G., Ottenhoff, Maarten C., Piña-Fuentes, Dan A. I., Potters, Wouter V., Reidinga, Auke C., Renckens, Roos S. C., Sander Rigter, Daisy Rusch, Michiel Schinkel, Sigaloff, Kim C. E., Suat Simsek, Patricia Stassen, Robert Stassen, Thomas, Rajat M., Wingen, Guido A., Anton Vonk Noordegraaf, Max Welling, Joost Wiersinga, W., Wolvers, Marije D. J., Caroline Wyers, Neurology, Amsterdam Neuroscience - Neurodegeneration, Center of Experimental and Molecular Medicine, Graduate School, Adult Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Infectious diseases, AII - Infectious diseases, and Clinical Research Unit
- Abstract
OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands. DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported. METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission. RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels. CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.