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20 results on '"Grisanzio, Chiara"'

1. p63 Regulates Commitment to the Prostate Cell Lineage

Author

Signoretti, Sabina, Pires, Maira M., Lindauer, Meghan, Horner, James W., Grisanzio, Chiara, Dhar, Sonya, Majumder, Pradip, McKeon, Frank, Kantoff, Philip W., Sellers, William R., Loda, Massimo, and Witte, Owen N.

Published
2005

4. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis

Author

Grisanzio, Chiara, Werner, Lillian, Takeda, David, Awoyemi, Bisola C., Pomerantz, Mark M., Yamada, Hiroki, Sooriakumaran, Prasanna, Robinson, Brian D., Leung, Robert, Schinzel, Anna C., Mills, Ian, Ross-Adams, Helen, Neal, David E., Kido, Masahito, Yamamoto, Toshihiro, Petrozziello, Gillian, Stack, Edward C., Lis, Rosina, Kantoff, Philip W., Loda, Massimo, Sartor, Oliver, Egawa, Shin, Tewari, Ashutosh K., Hahn, William C., and Freedman, Matthew L.

Published
2012

5. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Author

Lin, Wenchu, Cao, Jian, Liu, Jiayun, Beshiri, Michael L., Fujiwara, Yuko, Francis, Joshua, Cherniack, Andrew D., Geisen, Christoph, Blair, Lauren P., Zou, Mike R., Shen, Xiaohua, Kawamori, Dan, Liu, Zongzhi, Grisanzio, Chiara, Watanabe, Hideo, Minamishima, Yoji Andrew, Zhang, Qing, Kulkarni, Rohit N., Signoretti, Sabina, Rodig, Scott J., Bronson, Roderick T., Orkin, Stuart H., Tuck, David P., Benevolenskaya, Elizaveta V., Meyerson, Matthew, Kaelin, William G., and Yan, Qin

Published
2011

7. A Prostatic Intraepithelial Neoplasia-Dependent p27 Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

Author

Majumder, Pradip K., Grisanzio, Chiara, O'Connell, Fionnuala, Barry, Marc, Brito, Joseph M., Xu, Qing, Guney, Isil, Berger, Raanan, Herman, Paula, Bikoff, Rachel, Fedele, Giuseppe, Baek, Won-Ki, Wang, Shunyou, Ellwood-Yen, Katharine, Wu, Hong, Sawyers, Charles L., Signoretti, Sabina, Hahn, William C., Loda, Massimo, and Sellers, William R.

Published
2008
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8. A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression.

Author

Majumder, Pradip K., Grisanzio, Chiara, O'Connell, Fionnuala, Barry, Marc, Brito, Joseph M., Xu, Qing, Guney, Isil, Berger, Raanan, Herman, Paula, Bikoff, Rachel, Fedele, Giuseppe, Baek, Won-Ki, Wang, Shunyou, Ellwood-Yen, Katharine, Wu, Hong, Sawyers, Charles L., Signoretti, Sabina, Hahn, William C., Loda, Massimo, and Sellers, William R.

Subjects
*INHIBITION of cellular proliferation, *CANCER cell proliferation, *CELLULAR aging, *CANCER invasiveness
Published
2024
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10. Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer

Author

Migita, Toshiro, Ruiz, Stacey, Fornari, Alessandro, Fiorentino, Michelangelo, Priolo, Carmen, Zadra, Giorgia, Inazuka, Fumika, Grisanzio, Chiara, Palescandolo, Emanuele, Shin, Eyoung, Fiore, Christopher, Xie, Wanling, Kung, Andrew L., Febbo, Phillip G., Subramanian, Aravind, Mucci, Lorelei, Ma, Jing, Signoretti, Sabina, Stampfer, Meir, Hahn, William C., Finn, Stephen, and Loda, Massimo

Published
2009

12. Carbonic Anhydrase IX Expression in Renal Neoplasms

Author

Genega, Elizabeth M., primary, Ghebremichael, Musie, additional, Najarian, Robert, additional, Fu, Yineng, additional, Wang, Yihong, additional, Argani, Pedram, additional, Grisanzio, Chiara, additional, and Signoretti, Sabina, additional

Published
2010
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13. A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

Author

Majumder, Pradip K., primary, Grisanzio, Chiara, additional, O'Connell, Fionnuala, additional, Barry, Marc, additional, Brito, Joseph M., additional, Xu, Qing, additional, Guney, Isil, additional, Berger, Raanan, additional, Herman, Paula, additional, Bikoff, Rachel, additional, Fedele, Giuseppe, additional, Baek, Won-Ki, additional, Wang, Shunyou, additional, Ellwood-Yen, Katharine, additional, Wu, Hong, additional, Sawyers, Charles L., additional, Signoretti, Sabina, additional, Hahn, William C., additional, Loda, Massimo, additional, and Sellers, William R., additional

Published
2008
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15. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.

Author

Wenchu Lin, Jian Cao, Jiayun Lui, Beshiri, Michael L., Yuko Fujiwara, Francis, Joshua, Cherniack, Andrew D., Geisen, Christoph, Blair, Lauren P., Zou, Mike R., Xiaohua Shen, Kawamori, Dan, Zongzhi Liu, Grisanzio, Chiara, Watanabe, Hideo, Minamishima, Yoji Andrew, Qing Zhang, Kulkarni, Rohit N., Kulkarni, Sabina Signoretti!, and Scott J. Rodigh

Subjects
HISTONES, METHYLATION, CANCER, RETINOBLASTOMA, CARRIER proteins, LYSINE
Abstract

Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcription- ally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to tumor suppression by the retinoblastoma protein (pRB). Here, we show that genetic ablation of Rbp2 decreases tumor formation and prolongs survival in Rb1+/- mice and Menl-defective mice. These studies link RBP2 histone demethylase activity to tumorigenesis and nominate RBP2 as a potential target for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2011
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16. A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

Author

Majumder, Pradip K., Grisanzio, Chiara, O'Connell, Fionnuala, Barry, Marc, Brito, Joseph M., Xu, Qing, Guney, Isil, Berger, Raanan, Herman, Paula, Bikoff, Rachel, Fedele, Giuseppe, Baek, Won-Ki, Wang, Shunyou, Ellwood-Yen, Katharine, Wu, Hong, Sawyers, Charles L., Signoretti, Sabina, Hahn, William C., Loda, Massimo, and Sellers, William R.

Subjects
*PROSTATE cancer, *CANCER invasiveness, *CELL proliferation, *TRANSGENIC mice, *AGING
Abstract

Summary: Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP). In luminal epithelial cells of Akt-driven PIN, we show the concomitant induction of p27Kip1 and senescence. Genetic ablation of p27Kip1 led to downregulation of senescence markers and progression to cancer. In humans, p27Kip1 and senescence markers were elevated in PIN not associated with CaP but were decreased or absent, respectively, in cancer-associated PIN and in CaP. Importantly, p27Kip1 upregulation in mouse and human in situ lesions did not depend upon mTOR or Akt activation but was instead specifically associated with alterations in cell polarity, architecture, and adhesion molecules. These data suggest that a p27Kip1-driven checkpoint limits progression of PIN to CaP. [Copyright &y& Elsevier]

Published
2008
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18. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

Author

Young, Arthur P., Schlisio, Susanne, Minamishima, Yoji Andrew, Qing Zhang, Lianjie Li, Grisanzio, Chiara, Signoretti, Sabina, and Kaelin, William G.

Subjects
TUMOR suppressor genes, RENAL cell carcinoma, TRANSCRIPTION factors, PHENOTYPES, CHROMATIN
Abstract

Germline von Hippel–Lindau tumour suppressor gene (VHL) mutations cause renal cell carcinomas, haemangioblastomas and phaeochromocytomas in humans. Mutations in VHL also occur in sporadic renal cell carcinomas. The protein encoded by VHL, VHL, is part of the ubiquitin ligase that downregulates the heterodimeric transcription factor Hif under well-oxygenated conditions. Here we show that acute VHL inactivation causes a senescent-like phenotype in vitro and in vivo. This phenotype was independent of p53 and Hif but dependent on the retinoblastoma protein (Rb) and the SWI2/SNF2 chromatin remodeller p400. Rb activation occurred through a decrease in Skp2 messenger RNA, which resulted in the upregulation of p27 in a Hif-independent fashion. Our results suggest that senescence induced by VHL inactivation is a tumour-suppressive mechanism that must be overcome to develop VHL-associated neoplasias. [ABSTRACT FROM AUTHOR]

Published
2008
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19. Chromosome 8q24–Associated Cancers and MYC

Author

Van Dang, Chi, Grisanzio, Chiara, and Freedman, Matthew L.

Abstract

Genome-wide association studies (GWAS) have successfully identified common polymorphisms that are strongly associated with many traits, including cancer. A gene desert located on chromosome 8q24 is associated with multiple cancer types. One of the closest genes is the MYC proto-oncogene. Investigations are now turning toward a mechanistic understanding of these (and other) risk loci. Recent studies demonstrate that the 8q24 loci are enhancers and that they physically interact with MYC. A still unresolved issue is the absence of a consistent association between genotype status at the risk loci and steady-state MYC expression levels in adult human tissues. Clarifying the function of the 8q24 variants and their link to MYC regulation by further in vivoand in vitrofunctional studies will allow a deeper understanding of the mechanisms underlying human cancer development.

Published
2010
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20. Chromosome 8q24-Associated Cancers and MYC.

Author

Grisanzio C and Freedman ML

Abstract

Genome-wide association studies (GWAS) have successfully identified common polymorphisms that are strongly associated with many traits, including cancer. A gene desert located on chromosome 8q24 is associated with multiple cancer types. One of the closest genes is the MYC proto-oncogene. Investigations are now turning toward a mechanistic understanding of these (and other) risk loci. Recent studies demonstrate that the 8q24 loci are enhancers and that they physically interact with MYC. A still unresolved issue is the absence of a consistent association between genotype status at the risk loci and steady-state MYC expression levels in adult human tissues. Clarifying the function of the 8q24 variants and their link to MYC regulation by further in vivo and in vitro functional studies will allow a deeper understanding of the mechanisms underlying human cancer development.

Published
2010
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