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Objectives: Mineralocorticoid receptor (MR) are located in neuroretina and excessive glucocorticoid-dependent choroid activation in choroidal vessels is believed to play a large role in CSCR pathogenesis. The aim of this study was to examine eplerenone (Inspra, Pfizer), a MR antagonist as a potential treatment modality for acute CSCR. Materials and methods: A prospective cohort was carried out on patients diagnosed with acute CSCR receiving oral eplerenone. Spectral domain optical coherence tomography (SD-OCT) imaging was performed, including manual measurements of subretinal fluid (SRF) diameter and height at baseline and subsequent follow-up exams. The primary outcome measure of the study, was the best corrected visual acuity (BCVA) following eplerenone administration. Secondary outcome measures comprised, SRF diameter and height, cube volume (CV), cube average thickness (CAT) and central subfield thickness (CST). Results: 15 eyes of 15 patients diagnosed with acute CSCR, treated for a total of 28 days, with 50 mg/d of oral eplerenone. At study completion, statistically significant decreases from the baseline were observed in, SRF diameter (P, Ciljevi: Receptori za mineralokortikoide (MR) se nalaze u mrežnici i žilnici te se smatra da prenaglašena aktivacija žilničkih krvnih žila ovisna o djelovanju glukokortikoida igra značajnu ulogu u patogenezi CSCRa. Cilj ove studije je bio ispitati učinkovitost eplerenona (Inspra, Pfizer) u liječenju akutnog CSCRa. Materijali i metode: Ovo je bila prospektivna kohortna studija koja se provela na ispitanicima sa akutnom CSCR, a koji su bili liječeni oralnom primjenom eplerenona. Prilikom uključenja u studiju i svih daljnjih kontrolnih pregleda rađena je optička koherentna tomografija te mjerenje visine i dijametra subretinalne tekućine. Primarna mjera ishoda je bila promjena vidne oštrine nakon liječenja eplerenonom. Sekundarne mjere ishoda su bile: dijametar i visina subretinalne tekućine, CV (engl. Cube volume), CAT (engl. Cube average thickness) i CST (engl. Central subfield thickness). Rezultati: U studiju je bilo uključeno 15 očiju od 15 bolesnika sa akutnom CSCR, koji su bili liječeni kroz 28 dana dnevnom dozom od 50 mg eplerenona. Na kraju studije nađen je statistički značajan pad dijametra subretinalne tekućine (P

The chapter provides a comparative-law perspective- specifically the US and Italian models - on legal, civic and legal educational cultures. In particular, it describes the content of a proposed course in Street Law, being taught for the first time in Italy in the spring of 2019 at Roma Tre University. The course will instill law students with the tools and techniques needed to teach high school students the basics of civic education - including concepts such as rule of law, subsidiarity and democracy - largely lacking in the Italian educational system. By partnering with the non-profit volunteer organization Retake Roma, the course participants will organize a cleanup, involving the local Retake neighborhood group and a local high school. Didactic approaches, a best-practices lesson plan and interactive strategies are explored, as well as the challenges such a course will meet in the Italian legal-education system and local context. Other contributers to this volume include: Rebecca Grimes, Lee Arbetman, David McQuoid-Mason, Ulviyya Mikayilova, Lamiya Sharafkanova, Vitaly Radsky, Jeff Giddings, Arpeeta Mizan, Rolf Gollob, Lucia Madlenakova, Harrison Belley, Angeliki Aroni, Rosa Tedjabuwana, Hesti Septianita, Leni Widi Mulyani, John Lunney, Sean Arthurs, Chris Malcolm, Ramona Biholar, Bruce A. Lasky, Wendy Morrish, Stephen A. Rosenbaum, Bebs Chorak, Chigizori Ojiaka, Boubacar Tall, Coline Bruintjies, Nancy Flowers, A Gascón-Cuenca, Rainer Adam, Pimrapaat Dusadeeisariyakul, Ben Fourniotis, Seda Gayreti, Ted Huddlestone, Richard Grimes, Margaret Fisher, Judy Zimmer, Mary C. Larkin