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318 results on '"Grimer, Robert J."'

4. Surgical Downstaging in an Open-Label Phase II Trial of Denosumab in Patients with Giant Cell Tumor of Bone

Author

Rutkowski, Piotr, Ferrari, Stefano, Grimer, Robert J, Stalley, Paul D, Dijkstra, Sander PD, Pienkowski, Andrzej, Vaz, Gualter, Wunder, Jay S, Seeger, Leanne L, Feng, Amy, Roberts, Zachary J, and Bach, Bruce A

Subjects
Patient Safety, Clinical Research, Cancer, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Adult, Bone Density Conservation Agents, Bone Neoplasms, Combined Modality Therapy, Denosumab, Female, Follow-Up Studies, Giant Cell Tumor of Bone, Humans, Male, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Prospective Studies, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundSurgical resection with curative intent for giant cell tumor of bone (GCTB) may be associated with severe morbidity. This interim analysis evaluated reduction in surgical invasiveness after denosumab treatment in patients with resectable GCTB.MethodsPatients with primary or recurrent GCTB, for whom the initially planned surgery was associated with functional compromise or morbidity, received denosumab 120 mg subcutaneously every 4 weeks (additional doses on days 8 and 15 of the first cycle). Planned and actual GCTB-related surgical procedures before and after denosumab treatment were reported. Patients were followed for surgical outcome, adverse events, and recurrence following resection.ResultsOverall, 222 patients were evaluable for surgical downstaging (54 % were women; median age 34 years). Lesions (67 % primary and 33 % recurrent) were located in the axial (15 %) and appendicular skeleton (85 %). At the data cutoff date, most patients had not yet undergone surgery (n = 106; 48 %) or had a less morbid procedure (n = 84; 38 %) than originally planned. Median (interquartile range) time on denosumab was 19.5 (12.4-28.6) months for the 106 patients who had not undergone surgery and were continuing on monthly denosumab. Native joint preservation was 96 % (n = 24/25) for patients with planned joint/prosthesis replacement and 86 % (n = 30/35) for patients with planned joint resection/fusion. Of the 116 patients who had surgery (median postsurgical follow-up 13.0 [8.5-17.9] months), local recurrence occurred in 17 (15 %) patients.ConclusionFor patients with resectable GCTB, neoadjuvant denosumab therapy resulted in beneficial surgical downstaging, including either no surgery or a less morbid surgical procedure.

Published
2015

7. Supplementary Tables 2 and 3 from A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas

Author

Lee, Yin-Fai, primary, John, Megan, primary, Falconer, Alison, primary, Edwards, Sandra, primary, Clark, Jeremy, primary, Flohr, Penny, primary, Roe, Toby, primary, Wang, Rubin, primary, Shipley, Janet, primary, Grimer, Robert J., primary, Mangham, D. Chas, primary, Thomas, J. Meirion, primary, Fisher, Cyril, primary, Judson, Ian, primary, and Cooper, Colin S., primary

Published
2023
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8. Supplementary Figure 1 from A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas

Author

Lee, Yin-Fai, primary, John, Megan, primary, Falconer, Alison, primary, Edwards, Sandra, primary, Clark, Jeremy, primary, Flohr, Penny, primary, Roe, Toby, primary, Wang, Rubin, primary, Shipley, Janet, primary, Grimer, Robert J., primary, Mangham, D. Chas, primary, Thomas, J. Meirion, primary, Fisher, Cyril, primary, Judson, Ian, primary, and Cooper, Colin S., primary

Published
2023
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9. Supplementary Table 1 from A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas

Author

Lee, Yin-Fai, primary, John, Megan, primary, Falconer, Alison, primary, Edwards, Sandra, primary, Clark, Jeremy, primary, Flohr, Penny, primary, Roe, Toby, primary, Wang, Rubin, primary, Shipley, Janet, primary, Grimer, Robert J., primary, Mangham, D. Chas, primary, Thomas, J. Meirion, primary, Fisher, Cyril, primary, Judson, Ian, primary, and Cooper, Colin S., primary

Published
2023
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31. An epidemiological survey of tumour or tumour like conditions in the scapula and periscapular region

Author

Khan Zeeshan, Gerrish Adam M., and Grimer Robert J.

Subjects
Scapula, Periscapular, Lesions, Tumours, Sarcoma, Orthopedic surgery, RD701-811
Abstract

Introduction: The scapula is not an uncommon site for bone and soft tissue tumours and can be difficult to delineate on examination. Furthermore, these lesions can be potentially challenging to biopsy due to its close anatomical relationship with important structures. We present an epidemiological survey of all the scapular and periscapular lesions presenting to our institution. Methodology: This was a retrospective study with data obtained from a prospectively held electronic database over a 30-year period. Demographic and clinical data was obtained and various subgroup analyses were performed. Results: A total of 418 scapular lesions were included in the study where 132 lesions were found to be of soft tissue origin and 286 were osseous. Fifty-eight percent (n = 241) of all these lesions were malignant, of which 47% (n = 113) were primary sarcomas. The commonest malignant lesions were bone sarcomas (n = 96) followed by metastases (n = 88). The commonest primary bone sarcoma was chondrosarcoma (45%), whereas the commonest soft tissue sarcoma was high grade undifferentiated pleomorphic sarcoma (18%). The most common benign osseous and soft tissue lesions were osteochondroma (70%) and lipoma (26%), respectively. We noted that the incidence of malignancy increased with increasing age, however, the incidence of primary bone sarcomas was fairly consistent across different age groups. Conclusion: Based on our findings we recommend that suspicious lesions arising from the scapula should be dealt with in a specialist sarcoma unit with involvement of a multidisciplinary team to offer appropriate management and advice for optimum outcome.

Published
2016
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48. Correspondence

Author

Grimer, Robert J., Carter, Simon R., Tillman, Roger M., Bell, Robert S., Davis, Aileen M., Wunder, Jay S., Buconjic, Tom, McGoveran, Bruce, and Gross, Allan E.

Published
1998

49. Revision hip replacement for recurrent Hydatid disease of the pelvis: a case report and review of the literature

Author

Chandrasekar Coonoor R, Neelapala Venkata SS, and Grimer Robert J

Subjects
Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract A case of a large recurrent hydatid cyst involving the right ilium and right hip treated with excision of the cyst, Total hip replacement and revision of the acetabular component with a Tripolar articulation for cyst recurrence and acetabular component loosening is presented along with a review of the relevant literature. To our knowledge there is no reported case of Total Hip replacement and revision for hydatid disease involving the bony pelvis.

Published
2010
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