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2. POS1100 EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS: CLINICAL SUSPICION RED FLAGS IDENTIFICATION BY A SYSTEMATIC LITERATURE REVIEW AND MULTIDISCIPLINARY EXPERT CONSENSUS

Author

Solans-Laqué, R., primary, Cid, M., additional, Blanco, R., additional, Blanco-Aparicio, M., additional, Garcia-Moguel, I., additional, Arismendi-Nuñez, E., additional, Noblejas Mozo, A., additional, Perez-Grimaldi, F., additional, Labradror-Horrillo, M., additional, Domingo-Rivas, C., additional, Espigol-Frigole, G., additional, Sanchez-Toril, F., additional, Ortiz-Sanjuan, F., additional, Alvaro-Gracia, J. M., additional, and Rúa-Figueroa, Í., additional

Published
2024
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5. A pharmacoeconomic analysis from Italian guidelines for the management of prolactinomas

Author

Basile, M, Valentini, Ilaria, Attanasio, R, Cozzi, R, Persichetti, A, Samperi, I, Scoppola, A, Auriemma, R, De Menis, E, Esposito, F, Ferrante, E, Iatì, G, Mazzatenta, D, Poggi, M, Rudà, R, Tortora, F, Cruciani, F, Mitrova, Z, Saulle, R, Vecchi, S, Cappabianca, P, Paoletta, A, Bozzao, A, Caputo, M, Doglietto, F, Ferraù, F, Lania, Ag, Laureti, S, Lello, S, Locatelli, D, Maffei, P, Minniti, G, Peri, A, Ruini, C, Settanni, F, Silvani, A, Veronese, N, Grimaldi, F, Papini, E, Cicchetti, A, Valentini, I (ORCID:0000-0001-5940-7495), Basile, M, Valentini, Ilaria, Attanasio, R, Cozzi, R, Persichetti, A, Samperi, I, Scoppola, A, Auriemma, R, De Menis, E, Esposito, F, Ferrante, E, Iatì, G, Mazzatenta, D, Poggi, M, Rudà, R, Tortora, F, Cruciani, F, Mitrova, Z, Saulle, R, Vecchi, S, Cappabianca, P, Paoletta, A, Bozzao, A, Caputo, M, Doglietto, F, Ferraù, F, Lania, Ag, Laureti, S, Lello, S, Locatelli, D, Maffei, P, Minniti, G, Peri, A, Ruini, C, Settanni, F, Silvani, A, Veronese, N, Grimaldi, F, Papini, E, Cicchetti, A, and Valentini, I (ORCID:0000-0001-5940-7495)

Abstract

Background: Prolactinoma, the most common pituitary adenoma, is usually treated with dopamine agonist (DA) therapy like cabergoline. Surgery is second-line therapy, and radiotherapy is used if surgical treatment fails or in relapsing macroprolactinoma. Objective: This study aimed to provide economic evidence for the management of prolactinoma in Italy, using a cost-of-illness and cost-utility analysis that considered various treatment options, including cabergoline, bromocriptine, temozolomide, radiation therapy, and surgical strategies. Methods: The researchers conducted a systematic literature review for each research question on scientific data- bases and surveyed a panel of experts for each therapeutic procedure's specific drivers that contributed to its total cost. Results: The average cost of the first year of treatment was euro2,558.91 and euro3,287.40 for subjects with micro- prolactinoma and macroprolactinoma, respectively. Follow-up costs from the second to the fifth year after ini- tial treatment were euro798.13 and euro1,084.59 per year in both groups. Cabergoline had an adequate cost-utility profile, with an incremental cost-effectiveness ratio (ICER) of euro3,201.15 compared to bromocriptine, based on a willingness-to-pay of euro40,000 per quality-adjusted life year (QALY) in the reference economy. Endoscopic sur- gery was more cost-effective than cabergoline, with an ICER of euro44,846.64. Considering a willingness-to-pay of euro40,000/QALY, the baseline findings show cabergoline to have high cost utility and endoscopic surgery just a tad above that. Conclusions: Due to the favorable cost-utility profile and safety of surgical treatment, pituitary surgery should be considered more frequently as the initial therapeutic approach. This management choice could lead to better outcomes and an appropriate allocation of healthcare resources.

Published
2024

6. Searches for gravitational waves from known pulsars with S5 LIGO data

Author

The LIGO Scientific Collaboration, The Virgo Collaboration, Abbott, B. P., Abbott, R., Acernese, F., Adhikari, R., Ajith, P., Allen, B., Allen, G., Alshourbagy, M., Amin, R. S., Anderson, S. B., Anderson, W. G., Antonucci, F., Aoudia, S., Arain, M. A., Araya, M., Armandula, H., Armor, P., Arun, K. G., Aso, Y., Aston, S., Astone, P., Aufmuth, P., Aulbert, C., Babak, S., Baker, P., Ballardin, G., Ballmer, S., Barker, C., Barker, D., Barone, F., Barr, B., Barriga, P., Barsotti, L., Barsuglia, M., Barton, M. A., Bartos, I., Bassiri, R., Bastarrika, M., Bauer, Th. S., Behnke, B., Beker, M., Benacquista, M., Betzwieser, J., Beyersdorf, P. T., Bigotta, S., Bilenko, I. A., Billingsley, G., Birindelli, S., Biswas, R., Bizouard, M. A., Black, E., Blackburn, J. K., Blackburn, L., Blair, D., Bland, B., Boccara, C., Bodiya, T. P., Bogue, L., Bondu, F., Bonelli, L., Bork, R., Boschi, V., Bose, S., Bosi, L., Braccini, S., Bradaschia, C., Brady, P. R., Braginsky, V. B., Brau, J. E., Bridges, D. O., Brillet, A., Brinkmann, M., Brisson, V., Broeck, C. Van Den, Brooks, A. F., Brown, D. A., Brummit, A., Brunet, G., Budzynski, R., Bulik, T., Bullington, A., Bulten, H. J., Buonanno, A., Burmeister, O., Buskulic, D., Byer, R. L., Cadonati, L., Cagnoli, G., Calloni, E., Camp, J. B., Campagna, E., Cannizzo, J., Cannon, K. C., Canuel, B., Cao, J., Carbognani, F., Cardenas, L., Caride, S., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C., Cesarini, E., Chalermsongsak, T., Chalkley, E., Charlton, P., Chassande-Mottin, E., Chatterji, S., Chelkowski, S., Chen, Y., Chincarini, A., Christensen, N., Chung, C. T. Y., Clark, D., Clark, J., Clayton, J. H., Cleva, F., Coccia, E., Cokelaer, T., Colacino, C. N., Colas, J., Colla, A., Colombini, M., Conte, R., Cook, D., Corbitt, T. R. C., Corda, C., Cornish, N., Corsi, A., Coulon, J. -P., Coward, D., Coyne, D. C., Creighton, J. D. E., Creighton, T. D., Cruise, A. M., Culter, R. M., Cumming, A., Cunningham, L., Cuoco, E., Danilishin, S. L., D'Antonio, S., Danzmann, K., Dari, A., Dattilo, V., Daudert, B., Davier, M., Davies, G., Daw, E. J., Day, R., De Rosa, R., DeBra, D., Degallaix, J., del Prete, M., Dergachev, V., Desai, S., DeSalvo, R., Dhurandhar, S., Di Fiore, L., Di Lieto, A., Emilio, M. Di Paolo, Di Virgilio, A., Díaz, M., Dietz, A., Donovan, F., Dooley, K. L., Doomes, E. E., Drago, M., Drever, R. W. P., Dueck, J., Duke, I., Dumas, J. -C., Dwyer, J. G., Echols, C., Edgar, M., Effler, A., Ehrens, P., Espinoza, E., Etzel, T., Evans, M., Evans, T., Fafone, V., Fairhurst, S., Faltas, Y., Fan, Y., Fazi, D., Fehrmann, H., Ferrante, I., Fidecaro, F., Finn, L. S., Fiori, I., Flaminio, R., Flasch, K., Foley, S., Forrest, C., Fotopoulos, N., Fournier, J. -D., Franc, J., Franzen, A., Frasca, S., Frasconi, F., Frede, M., Frei, M., Frei, Z., Freise, A., Frey, R., Fricke, T., Fritschel, P., Frolov, V. V., Fyffe, M., Galdi, V., Gammaitoni, L., Garofoli, J. A., Garufi, F., Gemme, G., Genin, E., Gennai, A., Gholami, I., Giaime, J. A., Giampanis, S., Giardina, K. D., Giazotto, A., Goda, K., Goetz, E., Goggin, L. M., González, G., Gorodetsky, M. L., Goßler, S., Gouaty, R., Granata, M., Granata, V., Grant, A., Gras, S., Gray, C., Gray, M., Greenhalgh, R. J. S., Gretarsson, A. M., Greverie, C., Grimaldi, F., Grosso, R., Grote, H., Grunewald, S., Guenther, M., Guidi, G., Gustafson, E. K., Gustafson, R., Hage, B., Hallam, J. M., Hammer, D., Hammond, G. D., Hanna, C., Hanson, J., Harms, J., Harry, G. M., Harry, I. W., Harstad, E. D., Haughian, K., Hayama, K., Heefner, J., Heitmann, H., Hello, P., Heng, I. S., Heptonstall, A., Hewitson, M., Hild, S., Hirose, E., Hoak, D., Hodge, K. A., Holt, K., Hosken, D. J., Hough, J., Hoyland, D., Huet, D., Hughey, B., Huttner, S. H., Ingram, D. R., Isogai, T., Ito, M., Ivanov, A., Jaranowski, P., Johnson, B., Johnson, W. W., Jones, D. I., Jones, G., Jones, R., de la Jordana, L. Sancho, Ju, L., Kalmus, P., Kalogera, V., Kandhasamy, S., Kanner, J., Kasprzyk, D., Katsavounidis, E., Kawabe, K., Kawamura, S., Kawazoe, F., Kells, W., Keppel, D. G., Khalaidovski, A., Khalili, F. Y., Khan, R., Khazanov, E., King, P., Kissel, J. S., Klimenko, S., Kokeyama, K., Kondrashov, V., Kopparapu, R., Koranda, S., Kowalska, I., Kozak, D., Krishnan, B., Królak, A., Kumar, R., Kwee, P., La Penna, P., Lam, P. K., Landry, M., Lantz, B., Lazzarini, A., Lei, H., Lei, M., Leindecker, N., Leonor, I., Leroy, N., Letendre, N., Li, C., Lin, H., Lindquist, P. E., Littenberg, T. B., Lockerbie, N. A., Lodhia, D., Longo, M., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lu, P., Lubinski, M., Lucianetti, A., Lück, H., Machenschalk, B., MacInnis, M., Mackowski, J. -M., Mageswaran, M., Mailand, K., Majorana, E., Man, N., Mandel, I., Mandic, V., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A., Markowitz, J., Maros, E., Marque, J., Martelli, F., Martin, I. W., Martin, R. M., Marx, J. N., Mason, K., Masserot, A., Matichard, F., Matone, L., Matzner, R. A., Mavalvala, N., McCarthy, R., McClelland, D. E., McGuire, S. C., McHugh, M., McIntyre, G., McKechan, D. J. A., McKenzie, K., Mehmet, M., Melatos, A., Melissinos, A. C., Mendell, G., Menéndez, D. F., Menzinger, F., Mercer, R. A., Meshkov, S., Messenger, C., Meyer, M. S., Michel, C., Milano, L., Miller, J., Minelli, J., Minenkov, Y., Mino, Y., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Moe, B., Mohan, M., Mohanty, S. D., Mohapatra, S. R. P., Moreau, J., Moreno, G., Morgado, N., Morgia, A., Morioka, T., Mors, K., Mosca, S., Moscatelli, V., Mossavi, K., Mours, B., MowLowry, C., Mueller, G., Muhammad, D., Mühlen, H. zur, Mukherjee, S., Mukhopadhyay, H., Mullavey, A., Müller-Ebhardt, H., Munch, J., Murray, P. G., Myers, E., Myers, J., Nash, T., Nelson, J., Neri, I., Newton, G., Nishizawa, A., Nocera, F., Numata, K., Ochsner, E., O'Dell, J., Ogin, G. H., O'Reilly, B., O'Shaughnessy, R., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Pagliaroli, G., Palomba, C., Pan, Y., Pankow, C., Paoletti, F., Papa, M. A., Parameshwaraiah, V., Pardi, S., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, P., Pedraza, M., Penn, S., Perreca, A., Persichetti, G., Pichot, M., Piergiovanni, F., Pierro, V., Pietka, M., Pinard, L., Pinto, I. M., Pitkin, M., Pletsch, H. J., Plissi, M. V., Poggiani, R., Postiglione, F., Prato, M., Principe, M., Prix, R., Prodi, G. A., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Quetschke, V., Raab, F. J., Rabaste, O., Rabeling, D. S., Radkins, H., Raffai, P., Raics, Z., Rainer, N., Rakhmanov, M., Rapagnani, P., Raymond, V., Re, V., Reed, C. M., Reed, T., Regimbau, T., Rehbein, H., Reid, S., Reitze, D. H., Ricci, F., Riesen, R., Riles, K., Rivera, B., Roberts, P., Robertson, N. A., Robinet, F., Robinson, C., Robinson, E. L., Rocchi, A., Roddy, S., Rolland, L., Rollins, J., Romano, J. D., Romano, R., Romie, J. H., Rosinska, D., Röver, C., Rowan, S., Rüdiger, A., Ruggi, P., Russell, P., Ryan, K., Sakata, S., Salemi, F., Sandberg, V., Sannibale, V., Santamaría, L., Saraf, S., Sarin, P., Sassolas, B., Sathyaprakash, B. S., Sato, S., Satterthwaite, M., Saulson, P. R., Savage, R., Savov, P., Scanlan, M., Schilling, R., Schnabel, R., Schofield, R., Schulz, B., Schutz, B. F., Schwinberg, P., Scott, J., Scott, S. M., Searle, A. C., Sears, B., Seifert, F., Sellers, D., Sengupta, A. S., Sentenac, D., Sergeev, A., Shapiro, B., Shawhan, P., Shoemaker, D. H., Sibley, A., Siemens, X., Sigg, D., Sinha, S., Sintes, A. M., Slagmolen, B. J. J., Slutsky, J., van der Sluys, M. V., Smith, J. R., Smith, M. R., Smith, N. D., Somiya, K., Sorazu, B., Stein, A., Stein, L. C., Steplewski, S., Stochino, A., Stone, R., Strain, K. A., Strigin, S., Stroeer, A., Sturani, R., Stuver, A. L., Summerscales, T. Z., Sun, K. -X., Sung, M., Sutton, P. J., Swinkels, B., Szokoly, G. P., Talukder, D., Tang, L., Tanner, D. B., Tarabrin, S. P., Taylor, J. R., Taylor, R., Terenzi, R., Thacker, J., Thorne, K. A., Thorne, K. S., Thüring, A., Tokmakov, K. V., Toncelli, A., Tonelli, M., Torres, C., Torrie, C., Tournefier, E., Travasso, F., Traylor, G., Trias, M., Trummer, J., Ugolini, D., Ulmen, J., Urbanek, K., Vahlbruch, H., Vajente, G., Vallisneri, M., Brand, J. F. J. van den, van der Putten, S., Vass, S., Vaulin, R., Vavoulidis, M., Vecchio, A., Vedovato, G., van Veggel, A. A., Veitch, J., Veitch, P., Veltkamp, C., Verkindt, D., Vetrano, F., Viceré, A., Villar, A., Vinet, J. -Y., Vocca, H., Vorvick, C., Vyachanin, S. P., Waldman, S. J., Wallace, L., Ward, R. L., Was, M., Weidner, A., Weinert, M., Weinstein, A. J., Weiss, R., Wen, L., Wen, S., Wette, K., Whelan, J. T., Whitcomb, S. E., Whiting, B. F., Wilkinson, C., Willems, P. A., Williams, H. R., Williams, L., Willke, B., Wilmut, I., Winkelmann, L., Winkler, W., Wipf, C. C., Wiseman, A. G., Woan, G., Wooley, R., Worden, J., Wu, W., Yakushin, I., Yamamoto, H., Yan, Z., Yoshida, S., Yvert, M., Zanolin, M., Zhang, J., Zhang, L., Zhao, C., Zotov, N., Zucker, M. E., Zweizig, J., Bégin, S., Corongiu, A., D'Amico, N., Freire, P. C. C., Hessels, J. W. T., Hobbs, G. B., Kramer, M., Lyne, A. G., Manchester, R. N., Marshall, F. E., Middleditch, J., Possenti, A., Ransom, S. M., Stairs, I. H., and Stappers, B.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Galaxy Astrophysics, General Relativity and Quantum Cosmology
Abstract

We present a search for gravitational waves from 116 known millisecond and young pulsars using data from the fifth science run of the LIGO detectors. For this search ephemerides overlapping the run period were obtained for all pulsars using radio and X-ray observations. We demonstrate an updated search method that allows for small uncertainties in the pulsar phase parameters to be included in the search. We report no signal detection from any of the targets and therefore interpret our results as upper limits on the gravitational wave signal strength. The most interesting limits are those for young pulsars. We present updated limits on gravitational radiation from the Crab pulsar, where the measured limit is now a factor of seven below the spin-down limit. This limits the power radiated via gravitational waves to be less than ~2% of the available spin-down power. For the X-ray pulsar J0537-6910 we reach the spin-down limit under the assumption that any gravitational wave signal from it stays phase locked to the X-ray pulses over timing glitches, and for pulsars J1913+1011 and J1952+3252 we are only a factor of a few above the spin-down limit. Of the recycled millisecond pulsars several of the measured upper limits are only about an order of magnitude above their spin-down limits. For these our best (lowest) upper limit on gravitational wave amplitude is 2.3x10^-26 for J1603-7202 and our best (lowest) limit on the inferred pulsar ellipticity is 7.0x10^-8 for J2124-3358., Comment: 39 pages, 5 figures, Accepted in The Astrophysical Journal

Published
2009
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7. Search for gravitational-wave bursts associated with gamma-ray bursts using data from LIGO Science Run 5 and Virgo Science Run 1

Author

LIGO Scientific Collaboration, Virgo Collaboration, Abbott, B. P., Abbott, R., Acernese, F., Adhikari, R., Ajith, P., Allen, B., Allen, G., Alshourbagy, M., Amin, R. S., Anderson, S. B., Anderson, W. G., Antonucci, F., Aoudia, S., Arain, M. A., Araya, M., Armandula, H., Armor, P., Arun, K. G., Aso, Y., Aston, S., Astone, P., Aufmuth, P., Aulbert, C., Babak, S., Baker, P., Ballardin, G., Ballmer, S., Barker, C., Barker, D., Barone, F., Barr, B., Barriga, P., Barsotti, L., Barsuglia, M., Barton, M. A., Bartos, I., Bassiri, R., Bastarrika, M., Bauer, Th. S., Behnke, B., Beker, M., Benacquista, M., Betzwieser, J., Beyersdorf, P. T., Bigotta, S., Bilenko, I. A., Billingsley, G., Birindelli, S., Biswas, R., Bizouard, M. A., Black, E., Blackburn, J. K., Blackburn, L., Blair, D., Bland, B., Boccara, C., Bodiya, T. P., Bogue, L., Bondu, F., Bonelli, L., Bork, R., Boschi, V., Bose, S., Bosi, L., Braccini, S., Bradaschia, C., Brady, P. R., Braginsky, V. B., Brau, J. E., Bridges, D. O., Brillet, A., Brinkmann, M., Brisson, V., Broeck, C. Van Den, Brooks, A. F., Brown, D. A., Brummit, A., Brunet, G., Budzyński, R., Bulik, T., Bullington, A., Bulten, H. J., Buonanno, A., Burmeister, O., Buskulic, D., Byer, R. L., Cadonati, L., Cagnoli, G., Calloni, E., Camp, J. B., Campagna, E., Cannizzo, J., Cannon, K. C., Canuel, B., Cao, J., Carbognani, F., Cardenas, L., Caride, S., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C., Cesarini, E., Chalermsongsak, T., Chalkley, E., Charlton, P., Chassande-Mottin, E., Chatterji, S., Chelkowski, S., Chen, Y., Chincarini, A., Christensen, N., Chung, C. T. Y., Clark, D., Clark, J., Clayton, J. H., Cleva, F., Coccia, E., Cokelaer, T., Colacino, C. N., Colas, J., Colla, A., Colombini, M., Conte, R., Cook, D., Corbitt, T. R. C., Corda, C., Cornish, N., Corsi, A., Coulon, J. -P., Coward, D., Coyne, D. C., Creighton, J. D. E., Creighton, T. D., Cruise, A. M., Culter, R. M., Cumming, A., Cunningham, L., Cuoco, E., Danilishin, S. L., D'Antonio, S., Danzmann, K., Dari, A., Dattilo, V., Daudert, B., Davier, M., Davies, G., Daw, E. J., Day, R., De Rosa, R., DeBra, D., Degallaix, J., del Prete, M., Dergachev, V., Desai, S., DeSalvo, R., Dhurandhar, S., Di Fiore, L., Di Lieto, A., Emilio, M. Di Paolo, Di Virgilio, A., Díaz, M., Dietz, A., Donovan, F., Dooley, K. L., Doomes, E. E., Drago, M., Drever, R. W. P., Dueck, J., Duke, I., Dumas, J. -C., Dwyer, J. G., Echols, C., Edgar, M., Edwards, M., Effler, A., Ehrens, P., Espinoza, E., Etzel, T., Evans, M., Evans, T., Fafone, V., Fairhurst, S., Faltas, Y., Fan, Y., Fazi, D., Fehrmann, H., Ferrante, I., Fidecaro, F., Finn, L. S., Fiori, I., Flaminio, R., Flasch, K., Foley, S., Forrest, C., Fotopoulos, N., Fournier, J. -D., Franc, J., Franzen, A., Frasca, S., Frasconi, F., Frede, M., Frei, M., Frei, Z., Freise, A., Frey, R., Fricke, T., Fritschel, P., Frolov, V. V., Fyffe, M., Galdi, V., Gammaitoni, L., Garofoli, J. A., Garufi, F., Gemme, G., Genin, E., Gennai, A., Gholami, I., Giaime, J. A., Giampanis, S., Giardina, K. D., Giazotto, A., Goda, K., Goetz, E., Goggin, L. M., González, G., Gorodetsky, M. L., Goeßzetler, S., Goßler, S., Gouaty, R., Granata, M., Granata, V., Grant, A., Gras, S., Gray, C., Gray, M., Greenhalgh, R. J. S., Gretarsson, A. M., Greverie, C., Grimaldi, F., Grosso, R., Grote, H., Grunewald, S., Guenther, M., Guidi, G., Gustafson, E. K., Gustafson, R., Hage, B., Hallam, J. M., Hammer, D., Hammond, G. D., Hanna, C., Hanson, J., Harms, J., Harry, G. M., Harry, I. W., Harstad, E. D., Haughian, K., Hayama, K., Heefner, J., Heitmann, H., Hello, P., Heng, I. S., Heptonstall, A., Hewitson, M., Hild, S., Hirose, E., Hoak, D., Hodge, K. A., Holt, K., Hosken, D. J., Hough, J., Hoyland, D., Huet, D., Hughey, B., Huttner, S. H., Ingram, D. R., Isogai, T., Ito, M., Ivanov, A., Jaranowski, P., Johnson, B., Johnson, W. W., Jones, D. I., Jones, G., Jones, R., de la Jordana, L. Sancho, Ju, L., Kalmus, P., Kalogera, V., Kandhasamy, S., Kanner, J., Kasprzyk, D., Katsavounidis, E., Kawabe, K., Kawamura, S., Kawazoe, F., Kells, W., Keppel, D. G., Khalaidovski, A., Khalili, F. Y., Khan, R., Khazanov, E., King, P., Kissel, J. S., Klimenko, S., Kokeyama, K., Kondrashov, V., Kopparapu, R., Koranda, S., Kowalska, I., Kozak, D., Krishnan, B., Królak, A., Kumar, R., Kwee, P., La Penna, P., Lam, P. K., Landry, M., Lantz, B., Lazzarini, A., Lei, H., Lei, M., Leindecker, N., Leonor, I., Leroy, N., Letendre, N., Li, C., Lin, H., Lindquist, P. E., Littenberg, T. B., Lockerbie, N. A., Lodhia, D., Longo, M., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lu, P., Lubinski, M., Lucianetti, A., Lück, H., Machenschalk, B., MacInnis, M., Mackowski, J. -M., Mageswaran, M., Mailand, K., Majorana, E., Man, N., Mandel, I., Mandic, V., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A., Markowitz, J., Maros, E., Marque, J., Martelli, F., Martin, I. W., Martin, R. M., Marx, J. N., Mason, K., Masserot, A., Matichard, F., Matone, L., Matzner, R. A., Mavalvala, N., McCarthy, R., McClelland, D. E., McGuire, S. C., McHugh, M., McIntyre, G., McKechan, D. J. A., McKenzie, K., Mehmet, M., Melatos, A., Melissinos, A. C., Mendell, G., Menéndez, D. F., Menzinger, F., Mercer, R. A., Meshkov, S., Messenger, C., Meyer, M. S., Michel, C., Milano, L., Miller, J., Minelli, J., Minenkov, Y., Mino, Y., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Moe, B., Mohan, M., Mohanty, S. D., Mohapatra, S. R. P., Moreau, J., Moreno, G., Morgado, N., Morgia, A., Morioka, T., Mors, K., Mosca, S., Moscatelli, V., Mossavi, K., Mours, B., MowLowry, C., Mueller, G., Muhammad, D., Mühlen, H. zur, Mukherjee, S., Mukhopadhyay, H., Mullavey, A., Müller-Ebhardt, H., Munch, J., Murray, P. G., Myers, E., Myers, J., Nash, T., Nelson, J., Neri, I., Newton, G., Nishizawa, A., Nocera, F., Numata, K., Ochsner, E., O'Dell, J., Ogin, G. H., O'Reilly, B., O'Shaughnessy, R., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Pagliaroli, G., Palomba, C., Pan, Y., Pankow, C., Paoletti, F., Papa, M. A., Parameshwaraiah, V., Pardi, S., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, P., Pedraza, M., Penn, S., Perreca, A., Persichetti, G., Pichot, M., Piergiovanni, F., Pierro, V., Pietka, M., Pinard, L., Pinto, I. M., Pitkin, M., Pletsch, H. J., Plissi, M. V., Poggiani, R., Postiglione, F., Prato, M., Principe, M., Prix, R., Prodi, G. A., Prokhorov, L., Punken, O., Punturo, M., Puppo, P., Quetschke, V., Raab, F. J., Rabaste, O., Rabeling, D. S., Radkins, H., Raffai, P., Raics, Z., Rainer, N., Rakhmanov, M., Rapagnani, P., Raymond, V., Re, V., Reed, C. M., Reed, T., Regimbau, T., Rehbein, H., Reid, S., Reitze, D. H., Ricci, F., Riesen, R., Riles, K., Rivera, B., Roberts, P., Robertson, N. A., Robinet, F., Robinson, C., Robinson, E. L., Rocchi, A., Roddy, S., Rolland, L., Rollins, J., Romano, J. D., Romano, R., Romie, J. H., Rosińska, D., Röver, C., Rowan, S., Rüdiger, A., Ruggi, P., Russell, P., Ryan, K., Sakata, S., Salemi, F., Sandberg, V., Sannibale, V., Santamaría, L., Saraf, S., Sarin, P., Sassolas, B., Sathyaprakash, B. S., Sato, S., Satterthwaite, M., Saulson, P. R., Savage, R., Savov, P., Scanlan, M., Schilling, R., Schnabel, R., Schofield, R., Schulz, B., Schutz, B. F., Schwinberg, P., Scott, J., Scott, S. M., Searle, A. C., Sears, B., Seifert, F., Sellers, D., Sengupta, A. S., Sentenac, D., Sergeev, A., Shapiro, B., Shawhan, P., Shoemaker, D. H., Sibley, A., Siemens, X., Sigg, D., Sinha, S., Sintes, A. M., Slagmolen, B. J. J., Slutsky, J., van der Sluys, M. V., Smith, J. R., Smith, M. R., Smith, N. D., Somiya, K., Sorazu, B., Stein, A., Stein, L. C., Steplewski, S., Stochino, A., Stone, R., Strain, K. A., Strigin, S., Stroeer, A., Sturani, R., Stuver, A. L., Summerscales, T. Z., Sun, K. -X., Sung, M., Sutton, Patrick J., Swinkels, B., Szokoly, G. P., Talukder, D., Tang, L., Tanner, D. B., Tarabrin, S. P., Taylor, J. R., Taylor, R., Terenzi, R., Thacker, J., Thorne, K. A., Thorne, K. S., Thüring, A., Tokmakov, K. V., Toncelli, A., Tonelli, M., Torres, C., Torrie, C., Tournefier, E., Travasso, F., Traylor, G., Trias, M., Trummer, J., Ugolini, D., Ulmen, J., Urbanek, K., Vahlbruch, H., Vajente, G., Vallisneri, M., Brand, J. F. J. van den, van der Putten, S., Vass, S., Vaulin, R., Vavoulidis, M., Vecchio, A., Vedovato, G., van Veggel, A. A., Veitch, J., Veitch, P., Veltkamp, C., Verkindt, D., Vetrano, F., Viceré, A., Villar, A., Vinet, J. -Y., Vocca, H., Vorvick, C., Vyachanin, S. P., Waldman, S. J., Wallace, L., Ward, R. L., Was, M., Weidner, A., Weinert, M., Weinstein, A. J., Weiss, R., Wen, L., Wen, S., Wette, K., Whelan, J. T., Whitcomb, S. E., Whiting, B. F., Wilkinson, C., Willems, P. A., Williams, H. R., Williams, L., Willke, B., Wilmut, I., Winkelmann, L., Winkler, W., Wipf, C. C., Wiseman, A. G., Woan, G., Wooley, R., Worden, J., Wu, W., Yakushin, I., Yamamoto, H., Yan, Z., Yoshida, S., Yvert, M., Zanolin, M., Zhang, J., Zhang, L., Zhao, C., Zotov, N., Zucker, M. E., and Zweizig, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract

We present the results of a search for gravitational-wave bursts associated with 137 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments during the fifth LIGO science run and first Virgo science run. The data used in this analysis were collected from 2005 November 4 to 2007 October 1, and most of the GRB triggers were from the Swift satellite. The search uses a coherent network analysis method that takes into account the different locations and orientations of the interferometers at the three LIGO-Virgo sites. We find no evidence for gravitational-wave burst signals associated with this sample of GRBs. Using simulated short-duration (<1 s) waveforms, we set upper limits on the amplitude of gravitational waves associated with each GRB. We also place lower bounds on the distance to each GRB under the assumption of a fixed energy emission in gravitational waves, with typical limits of D ~ 15 Mpc (E_GW^iso / 0.01 M_o c^2)^1/2 for emission at frequencies around 150 Hz, where the LIGO-Virgo detector network has best sensitivity. We present astrophysical interpretations and implications of these results, and prospects for corresponding searches during future LIGO-Virgo runs., Comment: 16 pages, 3 figures. Updated references. To appear in ApJ.

Published
2009
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8. Beating the spin-down limit on gravitational wave emission from the Crab pulsar

Author

The LIGO Scientific Collaboration, Abbott, B., Abbott, R., Adhikari, R., Ajith, P., Allen, B., Allen, G., Amin, R., Anderson, S. B., Anderson, W. G., Arain, M. A., Araya, M., Armandula, H., Armor, P., Aso, Y., Aston, S., Aufmuth, P., Aulbert, C., Babak, S., Ballmer, S., Bantilan, H., Barish, B. C., Barker, C., Barker, D., Barr, B., Barriga, P., Barton, M. A., Bastarrika, M., Bayer, K., Betzwieser, J., Beyersdorf, P. T., Bilenko, I. A., Billingsley, G., Biswas, R., Black, E., Blackburn, K., Blackburn, L., Blair, D., Bland, B., Bodiya, T. P., Bogue, L., Bork, R., Boschi, V., Bose, S., Brady, P. R., Braginsky, V. B., Brau, J. E., Brinkmann, M., Brooks, A., Brown, D. A., Brunet, G., Bullington, A., Buonanno, A., Burmeister, O., Byer, R. L., Cadonati, L., Cagnoli, G., Camp, J. B., Cannizzo, J., Cannon, K., Cao, J., Cardenas, L., Casebolt, T., Castaldi, G., Cepeda, C., Chalkley, E., Charlton, P., Chatterji, S., Chelkowski, S., Chen, Y., Christensen, N., Clark, D., Clark, J., Cokelaer, T., Conte, R., Cook, D., Corbitt, T., Coyne, D., Creighton, J. D. E., Cumming, A., Cunningham, L., Cutler, R. M., Dalrymple, J., Danzmann, K., Davies, G., DeBra, D., Degallaix, J., Degree, M., Dergachev, V., Desai, S., DeSalvo, R., Dhurandhar, S., Díaz, M., Dickson, J., Dietz, A., Donovan, F., Dooley, K. L., Doomes, E. E., Drever, R. W. P., Duke, I., Dumas, J. -C., Dupuis, R. J., Dwyer, J. G., Echols, C., Effler, A., Ehrens, P., Espinoza, E., Etzel, T., Evans, T., Fairhurst, S., Fan, Y., Fazi, D., Fehrmann, H., Fejer, M. M., Finn, L. S., Flasch, K., Fotopoulos, N., Freise, A., Frey, R., Fricke, T., Fritschel, P., Frolov, V. V., Fyffe, M., Garofoli, J., Gholami, I., Giaime, J. A., Giampanis, S., Giardina, K. D., Goda, K., Goetz, E., Goggin, L., González, G., Gossler, S., Gouaty, R., Grant, A., Gras, S., Gray, C., Gray, M., Greenhalgh, R. J. S., Gretarsson, A. M., Grimaldi, F., Grosso, R., Grote, H., Grunewald, S., Guenther, M., Gustafson, E. K., Gustafson, R., Hage, B., Hallam, J. M., Hammer, D., Hanna, C., Hanson, J., Harms, J., Harry, G., Harstad, E., Hayama, K., Hayler, T., Heefner, J., Heng, I. S., Hennessy, M., Heptonstall, A., Hewitson, M., Hild, S., Hirose, E., Hoak, D., Hosken, D., Hough, J., Huttner, S. H., Ingram, D., Ito, M., Ivanov, A., Johnson, B., Johnson, W. W., Jones, D. I., Jones, ÂG., Jones, R., Ju, L., Kalmus, P., Kalogera, V., Kamat, S., Kanner, J., Kasprzyk, D., Katsavounidis, E., Kawabe, K., Kawamura, S., Kawazoe, F., Kells, W., Keppel, D. G., Khalili, F. Ya., Khan, R., Khazanov, E., Kim, C., King, P., Kissel, J. S., Klimenko, S., Kokeyama, K., Kondrashov, V., Kopparapu, R. K., Kozak, D., Kozhevatov, I., Krishnan, B., Kwee, P., Lam, P. K., Landry, M., Lang, M. M., Lantz, B., Lazzarini, A., Lei, M., Leindecker, N., Leonhardt, V., Leonor, I., Libbrecht, K., Lin, H., Lindquist, P., Lockerbie, N. A., Lodhia, D., Lormand, M., Lu, P., Lubinski, M., Lucianetti, A., Lück, H., Machenschalk, B., MacInnis, M., Mageswaran, M., Mailand, K., Mandic, V., Márka, S., Márka, Z., Markosyan, A., Markowitz, J., Maros, E., Martin, I., Martin, R. M., Marx, J. N., Mason, K., Matichard, F., Matone, L., Matzner, R., Mavalvala, N., McCarthy, R., McClelland, D. E., McGuire, S. C., McHugh, M., McIntyre, G., McIvor, G., McKechan, D., McKenzie, K., Meier, T., Melissinos, A., Mendell, G., Mercer, R. A., Meshkov, S., Messenger, C. J., Meyers, D., Miller, J., Minelli, J., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Moe, B., Mohanty, S., Moreno, G., Mossavi, K., MowLowry, C., Mueller, G., Mukherjee, S., Mukhopadhyay, H., Müller-Ebhardt, H., Munch, J., Murray, P., Myers, E., Myers, J., Nash, T., Nelson, J., Newton, G., Nishizawa, A., Numata, K., O'Dell, J., Ogin, G., O'Reilly, B., O'Shaughnessy, R., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Pan, Y., Pankow, C., Papa, M. A., Parameshwaraiah, V., Patel, P., Pedraza, M., Penn, S., Perreca, A., Petrie, T., Pinto, I. M., Pitkin, M., Pletsch, H. J., Plissi, M. V., Postiglione, F., Principe, M., Prix, R., Quetschke, V., Raab, F., Rabeling, D. S., Radkins, H., Rainer, N., Rakhmanov, M., Ramsunder, M., Rehbein, H., Reid, S., Reitze, D. H., Riesen, R., Riles, K., Rivera, B., Robertson, N. A., Robinson, C., Robinson, E. L., Roddy, S., Rodriguez, A., Rogan, A. M., Rollins, J., Romano, J. D., Romie, J., Route, R., Rowan, S., Rüdiger, A., Ruet, L., Russell, P., Ryan, K., Sakata, S., Samidi, M., de la Jordana, L. Sancho, Sandberg, V., Sannibale, V., Saraf, S., Sarin, P., Sathyaprakash, B. S., Sato, S., Saulson, P. R., Savage, R., Savov, P., Schediwy, S. W., Schilling, R., Schnabel, R., Schofield, R., Schutz, B. F., Schwinberg, P., Scott, S. M., Searle, A. C., Sears, B., Seifert, F., Sellers, D., Sengupta, A. S., Shawhan, P., Shoemaker, D. H., Sibley, A., Siemens, X., Sigg, D., Sinha, S., Sintes, A. M., Slagmolen, B. J. J., Slutsky, J., Smith, J. R., Smith, M. R., Smith, N. D., Somiya, K., Sorazu, B., Stein, L. C., Stochino, A., Stone, R., Strain, K. A., Strom, D. M., Stuver, A., Summerscales, T. Z., Sun, K. -X., Sung, M., Sutton, P. J., Takahashi, H., Tanner, D. B., Taylor, R., Thacker, J., Thorne, K. A., Thorne, K. S., Thüring, A., Tokmakov, K. V., Torres, C., Torrie, C., Traylor, G., Trias, M., Tyler, W., Ugolini, D., Ulmen, J., Urbanek, K., Vahlbruch, H., Broeck, C. Van Den, van der Sluys, M., Vass, S., Vaulin, R., Vecchio, A., Veitch, J., Veitch, P., Villar, A., Vorvick, C., Vyachanin, S. P., Waldman, S. J., Wallace, L., Ward, H., Ward, R., Weinert, M., Weinstein, A., Weiss, R., Wen, S., Wette, K., Whelan, J. T., Whitcomb, S. E., Whiting, B. F., Wilkinson, C., Willems, P. A., Williams, H. R., Williams, L., Willke, B., Wilmut, I., Winkler, W., Wipf, C. C., Wiseman, A. G., Woan, G., Wooley, R., Worden, J., Wu, W., Yakushin, I., Yamamoto, H., Yan, Z., Yoshida, S., Zanolin, M., Zhang, J., Zhang, L., Zhao, C., Zotov, N., Zucker, M., Zweizig, J., and Santostasi, G.

Subjects
Astrophysics, General Relativity and Quantum Cosmology
Abstract

We present direct upper limits on gravitational wave emission from the Crab pulsar using data from the first nine months of the fifth science run of the Laser Interferometer Gravitational-wave Observatory (LIGO). These limits are based on two searches. In the first we assume that the gravitational wave emission follows the observed radio timing, giving an upper limit on gravitational wave emission that beats indirect limits inferred from the spin-down and braking index of the pulsar and the energetics of the nebula. In the second we allow for a small mismatch between the gravitational and radio signal frequencies and interpret our results in the context of two possible gravitational wave emission mechanisms., Comment: Accepted for Ap. J. Lett. Minor changes in results due to calibration correction

Published
2008
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9. Analysis of charmonium production at fixed-target experiments in the NRQCD approach

Author

Maltoni, F., Spengler, J., Bargiotti, M., Bertin, A., Bruschi, M., De Castro, S., Fabbri, L., Faccioli, P., Giacobbe, B., Grimaldi, F., Massa, I., Piccinini, M., Semprini-Cesari, N., Spighi, R., Villa, M., Vitale, A., and Zoccoli, A.

Subjects
High Energy Physics - Phenomenology
Abstract

We present an analysis of the existing data on charmonium hadro-production based on non-relativistic QCD (NRQCD) calculations at the next-to-leading order (NLO). All the data on J/psi and psi' production in fixed-target experiments and on pp collisions at low energy are included. We find that the amount of color octet contribution needed to describe the data is about 1/10 of that found at the Tevatron.

Published
2006
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11. Optimal Duration of CPX-351 Treatment and Best Timing for Consolidation with Allogeneic Stem Cell Transplantation: Evidence from a Large Real-World Italian Study

Author

Guolo, F, Fianchi, L, Martelli, M, Chiusolo, P, Lussana, F, Grimaldi, F, Pilo, F, Rondoni, M, Fili, C, Capelli, D, Breccia, M, Mastaglio, S, Bocchia, M, Fumagalli, M, Galimberti, S, Mancini, V, Piccioni, A, Maurillo, L, Palmieri, R, Corbingi, A, Vetro, C, Sperotto, A, Gigli, F, Zappasodi, P, Mulé, A, Borlenghi, E, Dargenio, M, Lessi, F, Cerrano, M, Isidori, A, Brunetti, L, Papayannidis, C, Lunghi, M, Alati, C, Gatani, S, Mannelli, F, Fracchiolla, N, Gottardi, M, Cairoli, R, Ferrara, F, Lemoli, R, Venditti, A, Pagano, L, Todisco, E, Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, Todisco, Elisabetta, Guolo, F, Fianchi, L, Martelli, M, Chiusolo, P, Lussana, F, Grimaldi, F, Pilo, F, Rondoni, M, Fili, C, Capelli, D, Breccia, M, Mastaglio, S, Bocchia, M, Fumagalli, M, Galimberti, S, Mancini, V, Piccioni, A, Maurillo, L, Palmieri, R, Corbingi, A, Vetro, C, Sperotto, A, Gigli, F, Zappasodi, P, Mulé, A, Borlenghi, E, Dargenio, M, Lessi, F, Cerrano, M, Isidori, A, Brunetti, L, Papayannidis, C, Lunghi, M, Alati, C, Gatani, S, Mannelli, F, Fracchiolla, N, Gottardi, M, Cairoli, R, Ferrara, F, Lemoli, R, Venditti, A, Pagano, L, Todisco, E, Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, and Todisco, Elisabetta

Published
2023

12. Italian Guidelines for the Management of Prolactinomas

Author

Cozzi, R., Auriemma, R. S., De Menis, E., Esposito, F., Ferrante, E., Iati, G., Mazzatenta, D., Poggi, M., Ruda, R., Tortora, F., Cruciani, F., Mitrova, Z., Saulle, R., Vecchi, S., Basile, M., Cappabianca, P., Paoletta, A., Papini, E., Persichetti, A., Samperi, I., Scoppola, A., Bozzao, A., Caputo, M., Doglietto, Francesco, Ferrau, F., Lania, A. G., Laureti, S., Lello, S., Locatelli, D., Maffei, P., Minniti, G., Peri, A., Ruini, C., Settanni, F., Silvani, A., Veronese, N., Grimaldi, F., Attanasio, R., Doglietto F. (ORCID:0000-0002-7438-0734), Cozzi, R., Auriemma, R. S., De Menis, E., Esposito, F., Ferrante, E., Iati, G., Mazzatenta, D., Poggi, M., Ruda, R., Tortora, F., Cruciani, F., Mitrova, Z., Saulle, R., Vecchi, S., Basile, M., Cappabianca, P., Paoletta, A., Papini, E., Persichetti, A., Samperi, I., Scoppola, A., Bozzao, A., Caputo, M., Doglietto, Francesco, Ferrau, F., Lania, A. G., Laureti, S., Lello, S., Locatelli, D., Maffei, P., Minniti, G., Peri, A., Ruini, C., Settanni, F., Silvani, A., Veronese, N., Grimaldi, F., Attanasio, R., and Doglietto F. (ORCID:0000-0002-7438-0734)

Abstract

Introduction: This guideline (GL) is aimed at providing a reference for the management of prolactin (PRL)-secreting pituitary adenoma in adults. However, pregnancy is not considered. Methods: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinologi (AME) has identified potentially relevant outcomes, which have then been rated for their impact on therapeutic choices. Only outcomes classified as “critical” and “important” have been considered in the systematic review of evidence and only those classified as “critical” have been considered in the formulation of recommendations. Results: The present GL provides recommendations regarding the role of pharmacological and neurosurgical treatment in the management of prolactinomas. We recommend cabergoline (Cab) vs. bromocriptine (Br) as the first-choice pharmacological treatment to be employed at the minimal effective dose capable of achieving the regression of the clinical picture. We suggest that medication and surgery are offered as suitable alternative first-line treatments to patients with non-invasive PRL-secreting adenoma, regardless of size. We suggest Br as an alternative drug in patients who are intolerant to Cab and are not candidates for surgery. We recommend pituitary tumor resection in patients 1) without any significant neuro-ophthalmologic improvement within two weeks from the start of Cab, 2) who are resistant or do not tolerate Cab or other dopamine-agonist drugs (DA), 3) who escape from previous efficacy of DA, and 4) who are unwilling to undergo a chronic DA treatment. We recommend that patients with progressive disease notwithstanding previous tumor resection and ongoing DA should be managed by a multidisciplinary team with specific expertise in pituitary diseases using a multimodal approach that includes repeated surgery, radiother-apy, DA, and possibly, the use of temoz

Published
2023

15. Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

Author

Kuett, Laura, Catena, Raúl, Özcan, Alaz, Plüss, Alex, Ali, H. R., Sa’d, M. Al, Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E. S., Bressan, D., Bruna, A., Burger, Marcel, Caldas, C., Callari, M., Cannell, I. G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E. A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G. J., Harris, S., Jauset, C., Joyce, J. A., Karagiannis, E. D., Kovačević, T., Kuett, L., Kunes, R., Yoldaş, A. Küpcü, Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C. M., Nugent, I., O’Flanagan, C. H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A. J., Rueda, O. M., Ruiz, T., Sawicka, K., Sepúlveda, L. A., Shah, S. P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S. L., Walton, N. A., Wassie, A. T., Watson, S. S., Weselak, J., Wild, S. A., Williams, E., Windhager, J., Xia, C., Zheng, P., Zhuang, X., Schraml, Peter, Moch, Holger, de Souza, Natalie, and Bodenmiller, Bernd

Subjects
Cancer Research, Oncology
Abstract

A holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous detection of up to 40 antigens and transcripts using metal-tagged antibodies but has so far been restricted to two-dimensional imaging. Here we report the development of 3D IMC for multiplexed 3D tissue analysis at single-cell resolution and demonstrate the utility of the technology by analysis of human breast cancer samples. The resulting 3D models reveal cellular and microenvironmental heterogeneity and cell-level tissue organization not detectable in two dimensions. 3D IMC will prove powerful in the study of phenomena occurring in 3D space such as tumor cell invasion and is expected to provide invaluable insights into cellular microenvironments and tissue architecture.

Published
2021
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17. Knowledge, attitudes and adherence towards influenza and other vaccinations among healthcare workers at the University Hospital of Palermo, Italy, during the first COVID-19 pandemic season (2020/2021).

Author

Costantino, C., Bonaccorso, N., Balsamo, F., Belluzzo, M., Carubia, A., D'Azzo, L., Grimaldi, F., Sciortino, M., Vitello, T., Zagra, L., Graziano, G., Maida, C.M., Pieri, A., Mazzucco, W., Tramuto, F., Vitale, F., and Restivo, V.

Subjects
INFLUENZA vaccines, UNIVERSITY hospitals, COVID-19 pandemic, MEDICAL personnel
Abstract

Background. Increasing adherence to influenza vaccination among healthcare workers is a public health priority, stated that actually remains far below than international recommendations. During the 2020/2021 pandemic season, COVID-19 vaccines were not yet available until the end of December 2020, and influenza vaccines were the only one available to protect against seasonal respiratory diseases. The main objective of the present study was to assess knowledge, attitudes and adherence to influenza and other vaccinations recommended by the National Immunization Plan 2017-2021 for healthcare workers. Methods. Enrollment lasted from October and December 2020 at the vaccination unit of the University Hospital of Palermo. Data were collected through an anonymous and self-administered questionnaire, divided into 5 sections and 31 items. Results. Among 734 healthcare professionals that completed the survey, a significantly higher adherence to influenza vaccination was observed among healthcare workers that were more prone to receive COVID-19 vaccination (OR=4.02; 95% CI: 1.63-9.91). Moreover, higher influenza vaccination rates were observed among healthcare professionals that received influenza vaccination during previous 2019/2020 season (OR=15.3; 95% CI: 5.17-45.1) and that were favorable to the possible impact on increasing adherence of influenza mandatory vaccination (OR=4.88; 95% CI: 2.43-9.80). Conclusions. Propensity of healthcare workers to undergo vaccinations recommended in the National Immunization Plan increased during the first pandemic season. At the end of the vaccination season, flu vaccination coverage reached highest rates ever at the University Hospital of Palermo (around 60%), remaining anyway below the recommended minimum value of 75%. During next seasonal flu vaccination campaigns, it becomes essential to promote communication and information strategies to increase flu vaccination among healthcare workers, also focusing on co-administration with the anti-COVID-19 booster/seasonal doses. [ABSTRACT FROM AUTHOR]

Published
2023
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20. List of Contributors

Author

Ahmed, S.O., primary, Aldawsari, G., additional, Aljurf, M.D., additional, Alzahrani, H., additional, Ayas, M., additional, Bacigalupo, A., additional, Ciceri, F., additional, Cooper, J.N., additional, Dalle, J.H., additional, Dufour, C., additional, Elmahdi, S., additional, Farruggia, P., additional, Fioredda, F., additional, Gandhi, S., additional, Giraudier, S., additional, Gluckman, E., additional, Grimaldi, F., additional, Höchsmann, B., additional, Hosokawa, K., additional, Kojima, S., additional, Leblanc, T., additional, Marsh, J.C.W., additional, Meyran, D., additional, Miano, M., additional, Mufti, G.J., additional, Passweg, J.R., additional, de Latour, R. Peffault, additional, Risitano, A.M., additional, Rovó, A., additional, Ruggeri, A., additional, Samarasinghe, S., additional, Scheinberg, P., additional, Schrezenmeier, H., additional, Sica, S., additional, Stanghellini, M.T.L., additional, Tichelli, A., additional, Van Lint, M.T., additional, Warren, A.J., additional, and Young, N.S., additional

Published
2017
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23. PB2178: OUTCOMES OF REDUCED DOSE TEAM (THIOTEPA, ETOPOSIDE, CYTARABINE, MELPHALAN) PRIOR TO AUTOLOGOUS STEM CELL TRANSPLANTATION FOR HODGKIN AND NON-HODGKIN LYMPHOMA: A MONOCENTRIC EXPERIENCE

Author

Di Folca, S., primary, Marafioti, V., additional, barbato, S., additional, Avilia, S., additional, Grimaldi, F., additional, Severino, A., additional, Picardi, M., additional, Luciano, L., additional, Battipaglia, G., additional, and Pane, F., additional

Published
2022
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24. Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry

Author

Salzano, A, D'Assante, R, Iacoviello, M, Triggiani, V, Rengo, G, Cacciatore, F, Maiello, C, Limongelli, G, Masarone, D, Sciacqua, A, Perrone Filardi, P, Mancini, A, Volterrani, M, Vriz, O, Castello, R, Passantino, A, Campo, M, Modesti, Pa, De Giorgi, A, Arcopinto, M, Gargiulo, P, Perticone, M, Colao, A, Milano, S, Garavaglia, A, Napoli, R, Suzuki, T, Bossone, E, Marra, Am, Cittadini, A, Saccà, L, Monti, Mg, Matarazzo, M, Stagnaro, Fm, Piccioli, L, Lombardi, A, Panicara, V, Flora, M, Golia, L, Faga, V, Ruocco, A, Della Polla, D, Franco, R, Schiavo, A, Gigante, A, Spina, E, Sicuranza, M, Monaco, F, Apicella, M, Miele, C, Campanino, Ag, Mazza, L, Abete, R, Farro, A, Luciano, F, Polizzi, R, Ferrillo, G, De Luca, M, Crisci, G, Giardino, F, Barbato, M, Ranieri, B, Ferrara, F, Russo, V, Malinconico, M, Citro, R, Guastalamacchia, E, Leone, M, Giagulli, Va, Amarelli, C, Mattucci, I, Calabrò, P, Calabrò, R, D'Andrea, A, Maddaloni, V, Pacileo, G, Scarafile, R, Belfiore, A, Cimellaro, A, Casaretti, L, Paolillo, S, Favuzzi, Amr, Di Segni, C, Bruno, C, Vergani, E, Massaro, R, Grimaldi, F, Frigo, A, Sorrentino, Mr, Malandrino, D, Manfredini, R, Fabbian, F, Puzzo, A, Ragusa, L, Caliendo, L, Carbone, L, Frigiola, A, Generali, T, Giacomazzi, F, De Vincentiis, C, Ballotta, A, Garofalo, P, Malizia, G, Misiano, G, Israr, Mz, Bernieh, D, Cassambai, S, Yazaki, Y, Heaney, Lm, Eagle, Ka, Ventura, Ho, Bruzzese, D, Salzano, Andrea, D'Assante, Roberta, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Sciacqua, Angela, Filardi, Pasquale Perrone, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A, De Giorgi, Alfredo, Arcopinto, Michele, Gargiulo, Paola, Perticone, Maria, Colao, Annamaria, Milano, Salvatore, Garavaglia, Agnese, Napoli, Raffaele, Suzuki, Toru, Bossone, Eduardo, Marra, Alberto M, Cittadini, Antonio, and Misiano, Gabriella

Subjects
Registrie, Heart Failure, Endocrinology, Diabetes and Metabolism, Ventricular Dysfunction, Right, Diabetes, Insulins, Socio-culturale, Stroke Volume, Insulin resistance, Diabete, Cardiopulmonary exercise test, Chronic heart failure, Diabetes, Insulin resistance, Right ventricle, TOSCA Registry, Chronic heart failure, Diabetes Mellitus, Type 2, TOSCA Registry, Exercise Test, Ventricular Function, Right, Humans, Insulin, Right ventricle, Registries, Cardiology and Cardiovascular Medicine, Cardiopulmonary exercise test, TOSCA, Human, LS4_7
Abstract

Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance—IR or diabetes mellitus—T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF. Methods Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairment: euglycemic without IR (EU), euglycemic with IR (IR), and T2D. Results Compared with EU and IR, T2D was associated with increased filling pressures (E/e′ratio: 15.9 ± 8.9, 12.0 ± 6.5, and 14.5 ± 8.1 respectively, p 2) in TD2 vs EU and IR patients was recorded (respectively, 15.8 ± 3.8 ml/Kg/min, 18.4 ± 4.3 ml/Kg/min and 16.5 ± 4.3 ml/Kg/min, p 2 in the T2D group (+ 13% increase in RV dimension, − 21% decline in TAPSE/PAPS ratio and − 20% decrease in peak VO2). Conclusion The higher risk of death and CV hospitalizations exhibited by HF-T2D patients in the T.O.S.CA. Registry is associated with progressive RV ventricular dysfunction and exercise impairment when compared to euglycemic CHF patients, supporting the pivotal importance of hyperglycaemia and right chambers in HF prognosis. Trial registration ClinicalTrials.gov identifier: NCT023358017

Published
2022
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25. Association of Upfront Peptide Receptor Radionuclide Therapy With Progression-Free Survival Among Patients With Enteropancreatic Neuroendocrine Tumors

Author

Ricci, C., Pusceddu, S., Prinzi, N., Tafuto, S., Ibrahim, T., Filice, A., Brizzi, M. P., Panzuto, F., Baldari, S., Grana, C. M., Campana, D., Davi, M. V., Giuffrida, D., Zatelli, M. C., Partelli, S., Razzore, P., Marconcini, R., Massironi, S., Gelsomino, F., Faggiano, A., Giannetta, E., Bajetta, E., Grimaldi, F., Cives, M., Cirillo, F., Perfetti, V., Corti, F., Giacomelli, L., Porcu, L., Di Maio, M., Seregni, E., Maccauro, M., Lastoria, S., Bongiovanni, A., Versari, A., Persano, I., Rinzivillo, M., Pignata, S. A., Rocca, P. A., Lamberti, G., Cingarlini, S., Puliafito, I., Ambrosio, M. R., Zanata, I., Bracigliano, A., Severi, S., Spada, F., Andreasi, V., Modica, R., Scalorbi, F., Milione, M., Sabella, G., Coppa, J., Casadei, R., Di Bartolomeo, M., Falconi, M., De Braud, F., Pusceddu, Sara, Prinzi, Natalie, Tafuto, Salvatore, Ibrahim, Toni, Filice, Angelina, Brizzi, Maria Pia, Panzuto, Francesco, Baldari, Sergio, Grana, Chiara M., Campana, Davide, Davì, Maria Vittoria, Giuffrida, Dario, Zatelli, Maria Chiara, Partelli, Stefano, Razzore, Paola, Marconcini, Riccardo, Massironi, Sara, Gelsomino, Fabio, Faggiano, Antongiulio, Giannetta, Elisa, Bajetta, Emilio, Grimaldi, Franco, Cives, Mauro, Cirillo, Fernando, Perfetti, Vittorio, Corti, Francesca, Ricci, Claudio, Giacomelli, Luca, Porcu, Luca, Di Maio, Massimo, Seregni, Ettore, Maccauro, Marco, Lastoria, Secondo, Bongiovanni, Alberto, Versari, Annibale, Persano, Irene, Rinzivillo, Maria, Pignata, Salvatore Antonio, Rocca, Paola Anna, Lamberti, Giuseppe, Cingarlini, Sara, Puliafito, Ivana, Ambrosio, Maria Rosaria, Zanata, Isabella, Bracigliano, Alessandra, Severi, Stefano, Spada, Francesca, Andreasi, Valentina, Modica, Roberta, Scalorbi, Federica, Milione, Massimo, Sabella, Giovanna, Coppa, Jorgelina, Casadei, Riccardo, Di Bartolomeo, Maria, Falconi, Massimo, de Braud, Filippo, Grana, Chiara M, and Davi, Maria Vittoria

Subjects
Male, Radiotherapy, Receptors, Peptide, General Medicine, sequence, Middle Aged, peptide receptors radionuclide therapy, everolimus, chemotherapy, Progression-Free Survival, NO, Peptide Receptor Radionuclide Therapy, Pancreatic Neoplasms, Neuroendocrine Tumors, receptor radionuclide therapy, enteropancreatic neuroendocrine tumors, progression free survival, Receptors, Peptide, Humans, Female, LS4_3, neuroendocrine tumors, sequence, everolimus, Retrospective Studies
Abstract

Importance: Data about the optimal timing for the initiation of peptide receptor radionuclide therapy (PRRT) for advanced, well-differentiated enteropancreatic neuroendocrine tumors are lacking. Objective: To evaluate the association of upfront PRRT vs upfront chemotherapy or targeted therapy with progression-free survival (PFS) among patients with advanced enteropancreatic neuroendocrine tumors who experienced disease progression after treatment with somatostatin analogues (SSAs). Design, setting, and participants: This retrospective, multicenter cohort study analyzed the clinical records from 25 Italian oncology centers for patients aged 18 years or older who had unresectable, locally advanced or metastatic, well-differentiated, grades 1 to 3 enteropancreatic neuroendocrine tumors and received either PRRT or chemotherapy or targeted therapy after experiencing disease progression after treatment with SSAs between January 24, 2000, and July 1, 2020. Propensity score matching was done to minimize the selection bias. Exposures: Upfront PRRT or upfront chemotherapy or targeted therapy. Main outcomes and measures: The main outcome was the difference in PFS among patients who received upfront PRRT vs among those who received upfront chemotherapy or targeted therapy. A secondary outcome was the difference in overall survival between these groups. Hazard ratios (HRs) were fitted in a multivariable Cox proportional hazards regression model to adjust for relevant factors associated with PFS and were corrected for interaction with these factors. Results: Of 508 evaluated patients (mean ([SD] age, 55.7 [0.5] years; 278 [54.7%] were male), 329 (64.8%) received upfront PRRT and 179 (35.2%) received upfront chemotherapy or targeted therapy. The matched group included 222 patients (124 [55.9%] male; mean [SD] age, 56.1 [0.8] years), with 111 in each treatment group. Median PFS was longer in the PRRT group than in the chemotherapy or targeted therapy group in the unmatched (2.5 years [95% CI, 2.3-3.0 years] vs 0.7 years [95% CI, 0.5-1.0 years]; HR, 0.35 [95% CI, 0.28-0.44; P

Published
2022

26. COVID-19 infection in acute lymphoblastic leukemia over 15 months of the pandemic. A Campus ALL report

Author

Chiaretti, S., Bonifacio, M., Agrippino, R., Giglio, F., Annunziata, M., Curti, A., Del Principe, M. I., Salutari, P., Sciume, M., Delia, M., Armenio, M., Mancini, V., Mule, A., Grimaldi, F., Rege-Cambrin, G., Santoro, L., Lussana, F., Chiusolo, Patrizia, Pasciolla, C., Scattolin, A. M., Cerrano, M., Ciccone, M., Defina, M., Forghieri, F., Mazzone, C., Piccini, M., Ferrara, F., Pizzolo, G., Foa, R., Chiusolo P. (ORCID:0000-0002-1355-1587), Chiaretti, S., Bonifacio, M., Agrippino, R., Giglio, F., Annunziata, M., Curti, A., Del Principe, M. I., Salutari, P., Sciume, M., Delia, M., Armenio, M., Mancini, V., Mule, A., Grimaldi, F., Rege-Cambrin, G., Santoro, L., Lussana, F., Chiusolo, Patrizia, Pasciolla, C., Scattolin, A. M., Cerrano, M., Ciccone, M., Defina, M., Forghieri, F., Mazzone, C., Piccini, M., Ferrara, F., Pizzolo, G., Foa, R., and Chiusolo P. (ORCID:0000-0002-1355-1587)

Abstract

N/A

Published
2022

28. Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

Author

Kuett, L, Catena, R, ��zcan, A, Pl��ss, A, Ali, HR, Sa���d, MA, Alon, S, Aparicio, S, Battistoni, G, Balasubramanian, Shankar, Becker, R, Bodenmiller, B, Boyden, ES, Bressan, D, Bruna, A, Burger, M, Caldas, Carlos, Callari, M, Cannell, IG, Casbolt, H, Chornay, N, Cui, Y, Dariush, Aliakbar, Dinh, K, Emenari, A, Eyal-Lubling, Y, Fan, J, Fatemi, A, Fisher, E, Gonz��lez-Solares, EA, Gonz��lez-Fern��ndez, C, Goodwin, D, Greenwood, W, Grimaldi, F, Hannon, GJ, Harris, S, Jauset, C, Joyce, JA, Karagiannis, ED, Kova��evi��, T, Kunes, R, Yolda��, AK, Lai, D, Laks, E, Lee, H, Lee, M, Lerda, G, Li, Y, McPherson, A, Millar, N, Mulvey, CM, Nugent, I, O���Flanagan, CH, Paez-Ribes, M, Pearsall, I, Qosaj, F, Roth, AJ, Rueda, OM, Ruiz, T, Sawicka, K, Sep��lveda, LA, Shah, SP, Shea, A, Sinha, A, Smith, A, Tavar��, S, Tietscher, S, V��zquez-Garc��a, I, Vogl, SL, Walton, NA, Wassie, AT, Watson, SS, Weselak, J, Wild, SA, Williams, E, Windhager, J, Xia, C, Zheng, P, Zhuang, X, Schraml, P, Moch, H, De Souza, N, Ali, Raza [0000-0001-7587-0906], Balasubramanian, Shankar [0000-0002-0281-5815], Caldas, Carlos [0000-0003-3547-1489], Hannon, Gregory [0000-0003-4021-3898], Walton, Nicholas [0000-0003-3983-8778], and Apollo - University of Cambridge Repository

Subjects
Imaging, Three-Dimensional, Tumor Microenvironment, Humans, Breast Neoplasms, Female, Antibodies, Image Cytometry
Abstract

A holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous detection of up to 40 antigens and transcripts using metal-tagged antibodies but has so far been restricted to two-dimensional imaging. Here we report the development of 3D IMC for multiplexed 3D tissue analysis at single-cell resolution and demonstrate the utility of the technology by analysis of human breast cancer samples. The resulting 3D models reveal cellular and microenvironmental heterogeneity and cell-level tissue organization not detectable in two dimensions. 3D IMC will prove powerful in the study of phenomena occurring in 3D space such as tumor cell invasion and is expected to provide invaluable insights into cellular microenvironments and tissue architecture.

Published
2022

29. Position statement for clinical practice: prolactin-secreting tumors

Author

Cozzi, R, Ambrosio, Mr, Attanasio, R, Battista, C, Bozzao, A, Caputo, M, Ciccarelli, E, De Marinis, L, De Menis, E, Faustini Fustini, M, Grimaldi, F, Lania, A, Lasio, G, Logoluso, F, Losa, M, Maffei, P, Milani, D, Poggi, M, Zini, M, Katznelson, L, Luger, A, and Poiana, C.

Published
2022

31. Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry

Author

Cittadini A., Salzano A., Iacoviello M., Triggiani V., Rengo G., Cacciatore F., Maiello C., Limongelli G., Masarone D., Perticone F., Cimellaro A., Filardi P. P., Paolillo S., Mancini A., Volterrani M., Vriz O., Castello R., Passantino A., Campo M., Modesti P. A., de Giorgi A., Monte I. P., Puzzo A., Ballotta A., D'Assante R., Arcopinto M., Gargiulo P., Sciacqua A., Bruzzese D., Colao A., Napoli R., Suzuki T., Eagle K. A., Ventura H. O., Marra A. M., Bossone E., Sacca L., Monti M. G., Matarazzo M., Stagnaro F. M., Piccioli L., Lombardi A., Panicara V., Flora M., Golia L., Faga V., Ruocco A., della Polla D., Franco R., Schiavo A., Gigante A., Spina E., Sicuranza M., Monaco F., Apicella M., Miele C., Campanino A. G., Mazza L., Abete R., Farro A., Luciano F., Polizzi R., Ferrillo G., de Luca M., Crisci G., Giardino F., Barbato M., Ranieri B., Ferrara F., Russo V., Malinconico M., Citro R., Guastalamacchia E., Leone M., Giagulli V. A., Amarelli C., Mattucci I., Calabro P., Calabro R., D'Andrea A., Maddaloni V., Pacileo G., Scarafile R., Belfiore A., Casaretti L., Favuzzi A. M. R., Di Segni C., Bruno C., Vergani E., Massaro R., Grimaldi F., Frigo A., Campo M. R., Sorrentino M. R., Malandrino D., Manfredini R., Fabbian F., Ragusa L., Caliendo L., Carbone L., Frigiola A., Generali T., Giacomazzi F., de Vincentiis C., Garofalo P., Malizia G., Milano S., Misiano G., Israr M. Z., Bernieh D., Cassambai S., Yazaki Y., Heaney L. M., Cittadini, Antonio, Salzano, Andrea, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Perticone, Francesco, Cimellaro, Antonio, Perrone Filardi, Pasquale, Paolillo, Stefania, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A, De Giorgi, Alfredo, Monte, Ines P, Puzzo, Alfonso, Ballotta, Andrea, D'Assante, Roberta, Arcopinto, Michele, Gargiulo, Paola, Sciacqua, Angela, Bruzzese, Dario, Colao, Annamaria, Napoli, Raffaele, Suzuki, Toru, Eagle, Kim A, Ventura, Hector O, Marra, Alberto M, Bossone, Eduardo, Cittadini, A., Salzano, A., Iacoviello, M., Triggiani, V., Rengo, G., Cacciatore, F., Maiello, C., Limongelli, G., Masarone, D., Perticone, F., Cimellaro, A., Filardi, P. P., Paolillo, S., Mancini, A., Volterrani, M., Vriz, O., Castello, R., Passantino, A., Campo, M., Modesti, P. A., de Giorgi, A., Monte, I. P., Puzzo, A., Ballotta, A., D'Assante, R., Arcopinto, M., Gargiulo, P., Sciacqua, A., Bruzzese, D., Colao, A., Napoli, R., Suzuki, T., Eagle, K. A., Ventura, H. O., Marra, A. M., Bossone, E., Sacca, L., Monti, M. G., Matarazzo, M., Stagnaro, F. M., Piccioli, L., Lombardi, A., Panicara, V., Flora, M., Golia, L., Faga, V., Ruocco, A., della Polla, D., Franco, R., Schiavo, A., Gigante, A., Spina, E., Sicuranza, M., Monaco, F., Apicella, M., Miele, C., Campanino, A. G., Mazza, L., Abete, R., Farro, A., Luciano, F., Polizzi, R., Ferrillo, G., de Luca, M., Crisci, G., Giardino, F., Barbato, M., Ranieri, B., Ferrara, F., Russo, V., Malinconico, M., Citro, R., Guastalamacchia, E., Leone, M., Giagulli, V. A., Amarelli, C., Mattucci, I., Calabro, P., Calabro, R., D'Andrea, A., Maddaloni, V., Pacileo, G., Scarafile, R., Belfiore, A., Casaretti, L., Favuzzi, A. M. R., Di Segni, C., Bruno, C., Vergani, E., Massaro, R., Grimaldi, F., Frigo, A., Campo, M. R., Sorrentino, M. R., Malandrino, D., Manfredini, R., Fabbian, F., Ragusa, L., Caliendo, L., Carbone, L., Frigiola, A., Generali, T., Giacomazzi, F., de Vincentiis, C., Garofalo, P., Malizia, G., Milano, S., Misiano, G., Israr, M. Z., Bernieh, D., Cassambai, S., Yazaki, Y., and Heaney, L. M.

Subjects
medicine.medical_specialty, Multiple hormonal and metabolic deficiency syndrome, Epidemiology, Prognosi, Anabolic deficiency, Socio-culturale, Heart failure, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Diabetes mellitus, Internal medicine, Multiple hormonal, medicine, Clinical endpoint, Humans, 030212 general & internal medicine, Prospective Studies, Registries, TOSCA, LS4_7, Ejection fraction, business.industry, Hazard ratio, Metabolic deficiency syndrome, Heart failure • Anabolic deficiency • Multiple hormonal and metabolic deficiency syndrome • Hormones • Prognosis • TOSCA, Stroke Volume, medicine.disease, Prognosis, Hormone, Confidence interval, Heart failure, Anabolic deficiency, Multiple hormonal and metabolic deficiency syndrome, Hormones, Prognosis, TOSCA, Hormones, Hospitalization, Observational study, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Recent evidence supports the occurrence of multiple hormonal and metabolic deficiency syndrome (MHDS) in chronic heart failure (CHF). However, no large observational study has unequivocally demonstrated its impact on CHF progression and outcome. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Treatment in Heart Failure) Registry has been specifically designed to test the hypothesis that MHDS affects morbidity and mortality in CHF patients. Methods and Results The T.O.S.CA. Registry is a prospective, multicentre, observational study involving 19 Italian centres. Thyroid hormones, insulin-like growth factor-1, total testosterone, dehydropianoandrosterone sulfate, insulin resistance, and the presence of diabetes were evaluated. A MHDS was defined as the presence of ≥2 hormone deficiencies (HDs). Primary endpoint was a composite of all-cause mortality and cardiovascular hospitalizations. Four hundred and eighty heart failure patients with ejection fraction ≤45% were enrolled. MHDS or diabetes was diagnosed in 372 patients (77.5%). A total of 271 events (97 deaths and 174 cardiovascular hospitalizations) were recorded, 41% in NO-MHDS and 62% in MHDS (P Conclusion MHDS is common in CHF and independently associated with increased all-cause mortality and cardiovascular hospitalization, representing a promising therapeutic target. Trial registration ClinicalTrials.gov identifier: NCT023358017

Published
2021

37. Long-term Cryopreserved Autologous Hematopoietic Stem Cells Following Azacytidine to Successfully Treat Severe Invasive Pulmonary Aspergillosis After Therapy-Related Myelodysplastic Syndrome and CD8+ T-cell Autoimmune Disorders: A Case Report

Author

Giordano, C., primary, Severino, A., additional, Pugliese, N., additional, Cappuccio, I., additional, Rascato, M.G., additional, Salemme, A., additional, Avilia, S., additional, Cerciello, G., additional, Grimaldi, F., additional, Picardi, M., additional, and Pane, F., additional

Published
2021
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38. Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Author

Georgopoulou, Dimitra, Callari, Maurizio, Rueda, Oscar M., Shea, Abigail, Martin, Alistair, Giovannetti, Agnese, Qosaj, Fatime, Dariush, Ali, Chin, Suet-Feung, Carnevalli, Larissa S., Provenzano, Elena, Greenwood, Wendy, Lerda, Giulia, Esmaeilishirazifard, Elham, O’Reilly, Martin, Serra, Violeta, Bressan, Dario, Mills, Gordon B., Ali, H. Raza, Cosulich, Sabina S., Hannon, Gregory J., Bruna, Alejandra, Caldas, Carlos, Ali, H. R., Al Sa’d, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E. S., Bressan, D., Bruna, A., Burger, Marcel, Caldas, C., Callari, M., Cannell, I. G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E. A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G. J., Harris, O., Harris, S., Jauset, C., Joyce, J. A., Karagiannis, E. D., Kovačević, T., Kuett, L., Kunes, R., Küpcü, Yoldaş A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C. M., Nugent, F., O’Flanagan, C. H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A. J., Rueda, O. M., Ruiz, T., Sawicka, K., Sepúlveda, L. A., Shah, S. P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S. L., Walton, N. A., Wassie, A. T., Watson, S. S., Weselak, J., Wild, S. A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., Zhuang, X., Rueda, Oscar M. [0000-0003-0008-4884], Giovannetti, Agnese [0000-0001-5207-7243], Chin, Suet-Feung [0000-0001-5697-1082], Carnevalli, Larissa S. [0000-0001-7432-0195], Provenzano, Elena [0000-0003-3345-3965], Serra, Violeta [0000-0001-6620-1065], Bressan, Dario [0000-0003-3592-699X], Mills, Gordon B. [0000-0002-0144-9614], Ali, H. Raza [0000-0001-7587-0906], Caldas, Carlos [0000-0003-3547-1489], and Apollo - University of Cambridge Repository

Subjects
13/1, 13/105, article, 13/106, 38/39, 45/23, 631/67/1347, 631/67/2329
Abstract

Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289, Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325, The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes and their oncogenic signalling states in a biobank of patient-derived tumour xenograft (PDTX) models representing the diversity of human breast cancer. The BCMC panel identifies 13 cellular phenotypes (11 human and 2 murine), associated with both breast cancer subtypes and specific genomic features. Pre-treatment cellular phenotypic composition is a determinant of response to anticancer therapies. Single-cell profiling also reveals drug-induced cellular phenotypic dynamics, unravelling previously unnoticed intra-tumour response diversity. The comprehensive view of the landscapes of cellular phenotypic heterogeneity in PDTXs uncovered by the BCMC panel, which is mirrored in primary human tumours, has profound implications for understanding and predicting therapy response and resistance.

Published
2021
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39. Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. Data from a large prospective and retrospective Italian Epidemiological study: THE NET MANAGEMENT STUDY

Author

Faggiano, A., Ferolla, P., Grimaldi, F., Campana, D., Manzoni, M., Davì, M. V., Bianchi, A., Valcavi, R., Papini, E., Giuffrida, D., Ferone, D., Fanciulli, G., Arnaldi, G., Franchi, G. M., Francia, G., Fasola, G., Crinò, L., Pontecorvi, A., Tomassetti, P., and Colao, A.

Published
2012
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41. V0 production in p+A collisions at $\sqrt{s}=41.6$  GeV

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S. J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, Th. S., Belkov, A., Belkov, Ar., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K. M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H. B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, Ll., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D. C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Yu., Hansen, J. D., Hernández, J. M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Yu., Kisel, I., Klinkby, E., Knöpfle, K. T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Yu., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M. T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B. A., Piccinini, M., Pleier, M. A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A. J., Schwarz, A. S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Sözüer, L., Solunin, S., Somov, A., Somov, S., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H. S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Yu., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A. H., Walter, M., Wang, J. J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Xella-Hansen, S., Zaitsev, Yu., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., Zoccoli, A., and The HERA-B Collaboration

Published
2009
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42. Kinematic distributions and nuclear effects of J/ψ production in 920 GeV fixed-target proton-nucleus collisions

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S. J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, Th. S., Belkov, A., Belkov, Ar., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K. M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H. B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, Ll., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D. C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Yu., Hansen, J. D., Hernández, J. M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Yu., Kisel, I., Klinkby, E., Knöpfle, K. T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Yu., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M. T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B. AA., Piccinini, M., Pleier, M. A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A. J., Schwarz, A. S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Sözüer, L., Solunin, S., Somov, A., Somov, S., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H. S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Yu., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A. H., Walter, M., Wang, J. J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Xella-Hansen, S., Zaitsev, Yu., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., Zoccoli, A., and The HERA-B Collaboration

Published
2009
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43. Angular distributions of leptons from J/ψ’s produced in 920 GeV fixed-target proton-nucleus collisions

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S. J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, Th. S., Belkov, A., Belkov, Ar., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K. M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H. B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, Ll., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D. C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Yu., Hansen, J. D., Hernández, J. M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Yu., Kisel, I., Klinkby, E., Knöpfle, K. T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Yu., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M. T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B. AA., Piccinini, M., Pleier, M. A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A. J., Schwarz, A. S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Sözüer, L., Solunin, S., Somov, A., Somov, S., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H. S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Yu., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A. H., Walter, M., Wang, J. J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Xella-Hansen, S., Zaitsev, Yu., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., and Zoccoli, A.

Published
2009
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44. Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems

Author

Alon, Shahar, Goodwin, Daniel R., Sinha, Anubhav, Wassie, Asmamaw T., Chen, Fei, Daugharthy, Evan R., Bando, Yosuke, Kajita, Atsushi, Xue, Andrew G., Marrett, Karl, Prior, Robert, Cui, Yi, Payne, Andrew C., Yao, Chun-Chen, Suk, Ho-Jun, Wang, Ru, Yu, Chih-Chieh (Jay), Tillberg, Paul, Reginato, Paul, Pak, Nikita, Liu, Songlei, Punthambaker, Sukanya, Iyer, Eswar P. R., Kohman, Richie E., Miller, Jeremy A., Lein, Ed S., Lako, Ana, Cullen, Nicole, Rodig, Scott, Helvie, Karla, Abravanel, Daniel L., Wagle, Nikhil, Johnson, Bruce E., Klughammer, Johanna, Slyper, Michal, Waldman, Julia, Jané-Valbuena, Judit, Rozenblatt-Rosen, Orit, Regev, Aviv, Church, George M., Marblestone, Adam H., Boyden, Edward S., Ali, H. R., Al Sa’d, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E. S., Bressan, D., Bruna, A., Burger, Marcel, Caldas, C., Callari, M., Cannell, I. G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E. A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G. J., Harris, O., Harris, S., Jauset, C., Joyce, J. A., Karagiannis, E. D., Kovačević, T., Kuett, L., Kunes, R., Küpcü Yoldaş, A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C. M., Nugent, F., O'Flanagan, C. H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A. J., Rueda, O. M., Ruiz, T., Sawicka, K., Sepúlveda, L. A., Shah, S. P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S. L., Walton, N. A., Wassie, A. T., Watson, S. S., Weselak, J., Wild, S. A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., and Zhuang, X.

Subjects
In situ, Cell type, Dendritic spine, Sequence analysis, Dendritic Spines, Breast Neoplasms, Computational biology, Biology, Biochemistry, Article, Transcriptome, Mice, 03 medical and health sciences, Animals, Humans, splice, Molecular Biology, Gene, Visual Cortex, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Sequence Analysis, RNA, Gene Expression Profiling, Computational Biology, RNA, Cell Biology, Molecular Imaging, Female, Single-Cell Analysis, Biotechnology
Abstract

Identifying transcript location in cells Identifying where specific RNAs occur within a cell or tissue has been limited by technology and imaging capabilities. Expansion microscopy has allowed for better visualization of small structures by expanding the tissues with a polymer- and hydrogel-based system. Alon et al. combined expansion microscopy with long-read in situ RNA sequencing, resulting in a more precise visualization of the location of specific transcripts. This method, termed “ExSeq” for expansion sequencing, was used to detect RNAs, both new transcripts and those previously demonstrated to localize to neuronal dendrites. Unlike other in situ sequencing methods, ExSeq does not target sets of genes. This technology thus unites spatial resolution, multiplexing, and an unbiased approach to reveal insights into RNA localization and its physiological roles in developing and active tissue. Science , this issue p. eaax2656

Published
2021

46. Measurement of D0, D+, Ds + and D*+ production in fixed target 920 GeV proton–nucleus collisions

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S.J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, T.S., Belkov, A., Belkov, A., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K.M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H.B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, L., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D.C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Y., Hansen, J.D., Hernández, J.M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Y., Kisel, I., Klinkby, E., Knöpfle, K.T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Y., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M.T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B.A.A., Piccinini, M., Pleier, M.A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A.J., Schwarz, A.S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Škrk, D., Sözüer, L., Solunin, S., Somov, A., Somov, S., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H.S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Y., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A.H., Walter, M., Wang, J.J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Xella-Hansen, S., Zaitsev, Y., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., Zoccoli, A., and The HERA-B Collaboration

Published
2007
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47. K*0 and φ meson production in proton–nucleus interactions at $\sqrt{s}=41.6\text{GeV}$

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S.J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, T.S., Belkov, A., Belkov, A., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K.M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H.B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, L., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D.C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Y., Hansen, J.D., Hernández, J.M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Y., Kisel, I., Klinkby, E., Knöpfle, K.T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Y., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M.T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B.A., Piccinini, M., Pleier, M.A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A.J., Schwarz, A.S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Sözüer, L., Solunin, S., Somov, A., Somov, S., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H.S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Y., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A.H., Walter, M., Wang, J.J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Zaitsev, Y., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., and Zoccoli, A.

Published
2007
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48. A Measurement of the ψ′ to J/ψ production ratio in 920 GeV proton-nucleus interactions

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S.J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, T.S., Belkov, A., Belkov, A., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K.M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H.B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, L., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D.C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Y., Hansen, J.D., Hernández, J.M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Y., Kisel, I., Klinkby, E., Knöpfle, K.T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Y., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M.T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B.AA., Piccinini, M., Pleier, M.A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A.J., Schwarz, A.S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Sözüer, L., Solunin, S., Somov, A., Somov, S., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H.S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Yu., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A.H., Walter, M., Wang, J.J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Zaitsev, Y., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., Zoccoli, A., and The HERA-B Collaboration

Published
2007
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49. Luminosity determination at HERA-B

Author

Abt, I., Adams, M., Agari, M., Albrecht, H., Aleksandrov, A., Amaral, V., Amorim, A., Aplin, S.J., Aushev, V., Bagaturia, Y., Balagura, V., Bargiotti, M., Barsukova, O., Bastos, J., Batista, J., Bauer, C., Bauer, Th.S., Belkov, A., Belkov, Ar., Belotelov, I., Bertin, A., Bobchenko, B., Böcker, M., Bogatyrev, A., Bohm, G., Bräuer, M., Bruinsma, M., Bruschi, M., Buchholz, P., Buran, T., Carvalho, J., Conde, P., Cruse, C., Dam, M., Danielsen, K.M., Danilov, M., De Castro, S., Deppe, H., Dong, X., Dreis, H.B., Egorytchev, V., Ehret, K., Eisele, F., Emeliyanov, D., Essenov, S., Fabbri, L., Faccioli, P., Feuerstack-Raible, M., Flammer, J., Fominykh, B., Funcke, M., Garrido, Ll., Gellrich, A., Giacobbe, B., Gläß, J., Goloubkov, D., Golubkov, Y., Golutvin, A., Golutvin, I., Gorbounov, I., Gorišek, A., Gouchtchine, O., Goulart, D.C., Gradl, S., Gradl, W., Grimaldi, F., Groth-Jensen, J., Guilitsky, Yu., Hansen, J.D., Hernández, J.M., Hofmann, W., Hohlmann, M., Hott, T., Hulsbergen, W., Husemann, U., Igonkina, O., Ispiryan, M., Jagla, T., Jiang, C., Kapitza, H., Karabekyan, S., Karpenko, N., Keller, S., Kessler, J., Khasanov, F., Kiryushin, Yu., Kisel, I., Klinkby, E., Knöpfle, K.T., Kolanoski, H., Korpar, S., Krauss, C., Kreuzer, P., Križan, P., Krücker, D., Kupper, S., Kvaratskheliia, T., Lanyov, A., Lau, K., Lewendel, B., Lohse, T., Lomonosov, B., Männer, R., Mankel, R., Masciocchi, S., Massa, I., Matchikhilian, I., Medin, G., Medinnis, M., Mevius, M., Michetti, A., Mikhailov, Yu., Mizuk, R., Muresan, R., zur Nedden, M., Negodaev, M., Nörenberg, M., Nowak, S., Núñez Pardo de Vera, M.T., Ouchrif, M., Ould-Saada, F., Padilla, C., Peralta, D., Pernack, R., Pestotnik, R., Petersen, B.AA., Piccinini, M., Pleier, M.A., Poli, M., Popov, V., Pose, D., Prystupa, S., Pugatch, V., Pylypchenko, Y., Pyrlik, J., Reeves, K., Reßing, D., Rick, H., Riu, I., Robmann, P., Rostovtseva, I., Rybnikov, V., Sánchez, F., Sbrizzi, A., Schmelling, M., Schmidt, B., Schreiner, A., Schröder, H., Schwanke, U., Schwartz, A.J., Schwarz, A.S., Schwenninger, B., Schwingenheuer, B., Sciacca, F., Semprini-Cesari, N., Shuvalov, S., Silva, L., Sözüer, L., Solunin, S., Somov, S., Somov, A., Spengler, J., Spighi, R., Spiridonov, A., Stanovnik, A., Starič, M., Stegmann, C., Subramania, H.S., Symalla, M., Tikhomirov, I., Titov, M., Tsakov, I., Uwer, U., van Eldik, C., Vassiliev, Yu., Villa, M., Vitale, A., Vukotic, I., Wahlberg, H., Walenta, A.H., Walter, M., Wang, J.J., Wegener, D., Werthenbach, U., Wolters, H., Wurth, R., Wurz, A., Xella-Hansen, S., Zaitsev, Yu., Zavertyaev, M., Zeuner, T., Zhelezov, A., Zheng, Z., Zimmermann, R., Živko, T., and Zoccoli, A.

Published
2007
Full Text
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