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2. Multidistrict atherosclerotic disease: epidemiological and clinical framework

Author

Di Fusco, S, Abrignani, M, Amico, A, Luca, F, Mureddu, G, Ceravolo, R, Temporelli, P, Acerbo, V, Altamura, V, Baccino, D, Binaghi, G, Bugani, G, Cesaro, A, Ciccirillo, F, Cocozza, S, D'Errigo, P, Di Martino, M, Di Nora, C, Fileti, L, Lopriore, V, Maloberti, A, Monitillo, F, Gulizia, M, Grimaldi, M, Gabrielli, D, Oliva, F, Colivicchi, F, Di Fusco S. A., Abrignani M. G., Amico A. F., Luca F., Mureddu G. F., Ceravolo R., Temporelli P. L., Acerbo V., Altamura V., Baccino D., Binaghi G., Bugani G., Cesaro A., Ciccirillo F., Cocozza S., D'Errigo P., Di Martino M., Di Nora C., Fileti L., Lopriore V., Maloberti A., Monitillo F., Gulizia M. M., Grimaldi M., Gabrielli D., Oliva F., Colivicchi F., Di Fusco, S, Abrignani, M, Amico, A, Luca, F, Mureddu, G, Ceravolo, R, Temporelli, P, Acerbo, V, Altamura, V, Baccino, D, Binaghi, G, Bugani, G, Cesaro, A, Ciccirillo, F, Cocozza, S, D'Errigo, P, Di Martino, M, Di Nora, C, Fileti, L, Lopriore, V, Maloberti, A, Monitillo, F, Gulizia, M, Grimaldi, M, Gabrielli, D, Oliva, F, Colivicchi, F, Di Fusco S. A., Abrignani M. G., Amico A. F., Luca F., Mureddu G. F., Ceravolo R., Temporelli P. L., Acerbo V., Altamura V., Baccino D., Binaghi G., Bugani G., Cesaro A., Ciccirillo F., Cocozza S., D'Errigo P., Di Martino M., Di Nora C., Fileti L., Lopriore V., Maloberti A., Monitillo F., Gulizia M. M., Grimaldi M., Gabrielli D., Oliva F., and Colivicchi F.

Abstract

Atherosclerosis is a systemic disease that can involve different arterial districts. Traditionally, the focus of cardiologists has been on the diagnosis and treatment of atherosclerotic coronary artery disease (CAD). However, atherosclerosis localization in other districts is increasingly common and is associated with an increased risk of CAD and, more generally, of adverse cardiovascular events. Although the term peripheral arterial disease (PAD) commonly refers to the localization of atherosclerotic disease in the arterial districts of the lower limbs, in this document, in accordance with the European Society of Cardiology guidelines, the term PAD will be used for all the locations of atherosclerotic disease excluding coronary and aortic ones. The aim of this review is to report updated data on PAD epidemiology, with particular attention to the prevalence and its prognostic impact on patients with CAD. Furthermore, the key points for an appropriate diagnostic framework and a correct pharmacological therapeutic approach are summarized, while surgical/interventional treatment goes beyond the scope of this review.

Published
2024

3. Hyperkalaemia in Cardiological Patients: New Solutions for an Old Problem

Author

Abrignani, M, Gronda, E, Marini, M, Gori, M, Iacoviello, M, Temporelli, P, Benvenuto, M, Binaghi, G, Cesaro, A, Maloberti, A, Tinti, M, Riccio, C, Colivicchi, F, Grimaldi, M, Gabrielli, D, Oliva, F, Abrignani M. G., Gronda E., Marini M., Gori M., Iacoviello M., Temporelli P. L., Benvenuto M., Binaghi G., Cesaro A., Maloberti A., Tinti M. D., Riccio C., Colivicchi F., Grimaldi M., Gabrielli D., Oliva F., Abrignani, M, Gronda, E, Marini, M, Gori, M, Iacoviello, M, Temporelli, P, Benvenuto, M, Binaghi, G, Cesaro, A, Maloberti, A, Tinti, M, Riccio, C, Colivicchi, F, Grimaldi, M, Gabrielli, D, Oliva, F, Abrignani M. G., Gronda E., Marini M., Gori M., Iacoviello M., Temporelli P. L., Benvenuto M., Binaghi G., Cesaro A., Maloberti A., Tinti M. D., Riccio C., Colivicchi F., Grimaldi M., Gabrielli D., and Oliva F.

Abstract

Hyperkalaemia is one of the most common electrolyte disorders in patients with cardiovascular disease (CVD). The true burden of hyperkalaemia in the real-world setting can be difficult to assess, but in population-based cohort studies up to 4 in 10 patients developed hyperkalaemia. In addition to drugs interfering with potassium metabolism and food intake, several conditions can cause or worsen hyperkalaemia, such as advanced age, diabetes, and chronic kidney disease. Mortality, cardiovascular morbidity, and hospitalisation are higher in patients with hyperkalaemia. Hyperkalaemia represents a major contraindication or a withholding cause for disease-modifying therapies like renin–angiotensin–aldosterone inhibitors (RAASi), mainly mineralocorticoid receptor antagonists. Hyperkalaemia can be also classified as acute and chronic, according to the onset. Acute hyperkalaemia is often a life-threatening emergency requiring immediate treatment to avoid lethal arrhythmias. Therapy goal is cell membrane stabilisation by calcium administration, cellular intake, shift of extracellular potassium to the intracellular space (insulin, beta-adrenergic agents, sodium bicarbonate), and increased elimination with diuretics or dialysis. Chronic hyperkalaemia was often managed with dietary counselling to prevent potassium-rich food intake and tapering of potassium-increasing drugs, mostly RAASi. Sodium polystyrene sulphonate, a potassium binder, was the only therapeutic option. Recently, new drugs such as patiromer and sodium zirconium cyclosilicate give new opportunities for the treatment of hyperkalaemia, as they proved to be safe, well tolerated, and effective. Aim of this review is to describe the burden of hyperkalaemia in cardiovascular patients, its direct and indirect effects, and the therapeutic options now available in the acute and chronic setting.

Published
2024

4. Heart Failure with Preserved Ejection Fraction: How to Deal with This Chameleon

Author

Luca, F, Oliva, F, Abrignani, M, Di Fusco, S, Gori, M, Giubilato, S, Ceravolo, R, Temporelli, P, Cornara, S, Rao, C, Caretta, G, Pozzi, A, Binaghi, G, Maloberti, A, Di Nora, C, Di Matteo, I, Pilleri, A, Gelsomino, S, Riccio, C, Grimaldi, M, Colivicchi, F, Gulizia, M, Luca F., Oliva F., Abrignani M. G., Di Fusco S. A., Gori M., Giubilato S., Ceravolo R., Temporelli P. L., Cornara S., Rao C. M., Caretta G., Pozzi A., Binaghi G., Maloberti A., Di Nora C., Di Matteo I., Pilleri A., Gelsomino S., Riccio C., Grimaldi M., Colivicchi F., Gulizia M. M., Luca, F, Oliva, F, Abrignani, M, Di Fusco, S, Gori, M, Giubilato, S, Ceravolo, R, Temporelli, P, Cornara, S, Rao, C, Caretta, G, Pozzi, A, Binaghi, G, Maloberti, A, Di Nora, C, Di Matteo, I, Pilleri, A, Gelsomino, S, Riccio, C, Grimaldi, M, Colivicchi, F, Gulizia, M, Luca F., Oliva F., Abrignani M. G., Di Fusco S. A., Gori M., Giubilato S., Ceravolo R., Temporelli P. L., Cornara S., Rao C. M., Caretta G., Pozzi A., Binaghi G., Maloberti A., Di Nora C., Di Matteo I., Pilleri A., Gelsomino S., Riccio C., Grimaldi M., Colivicchi F., and Gulizia M. M.

Abstract

Heart failure with preserved ejection fraction (HFpEF) is characterized by a notable heterogeneity in both phenotypic and pathophysiological features, with a growing incidence due to the increase in median age and comorbidities such as obesity, arterial hypertension, and cardiometabolic disease. In recent decades, the development of new pharmacological and non-pharmacological options has significantly impacted outcomes, improving clinical status and reducing mortality. Moreover, a more personalized and accurate therapeutic management has been demonstrated to enhance the quality of life, diminish hospitalizations, and improve overall survival. Therefore, assessing the peculiarities of patients with HFpEF is crucial in order to obtain a better understanding of this disorder. Importantly, comorbidities have been shown to influence symptoms and prognosis, and, consequently, they should be carefully addressed. In this sense, it is mandatory to join forces with a multidisciplinary team in order to achieve high-quality care. However, HFpEF remains largely under-recognized and under-treated in clinical practice, and the diagnostic and therapeutic management of these patients remains challenging. The aim of this paper is to articulate a pragmatic approach for patients with HFpEF focusing on the etiology, diagnosis, and treatment of HFpEF.

Published
2024

5. Lipoproteina(a): associazione con la malattia aterosclerotica e valvolare e terapie emergenti

Author

Abrignani, M, Maloberti, A, Fusco, S, Luca, F, Cesaro, A, Acerbo, V, Fabbri, S, Matteo, I, Amico, A, Temporelli, P, Riccio, C, Colivicchi, F, Grimaldi, M, Gabrielli, D, Oliva, F, Abrignani M. G., Maloberti A., Fusco S. A. D., Luca F., Cesaro A., Acerbo V., Fabbri S., Matteo I. D., Amico A. F., Temporelli P. L., Riccio C., Colivicchi F., Grimaldi M., Gabrielli D., Oliva F., Abrignani, M, Maloberti, A, Fusco, S, Luca, F, Cesaro, A, Acerbo, V, Fabbri, S, Matteo, I, Amico, A, Temporelli, P, Riccio, C, Colivicchi, F, Grimaldi, M, Gabrielli, D, Oliva, F, Abrignani M. G., Maloberti A., Fusco S. A. D., Luca F., Cesaro A., Acerbo V., Fabbri S., Matteo I. D., Amico A. F., Temporelli P. L., Riccio C., Colivicchi F., Grimaldi M., Gabrielli D., and Oliva F.

Abstract

Lipoprotein(a) [Lp(a)] is a well-established cardiovascular risk factor, whose relationship with atherosclerotic disease has been confirmed by epidemiological, genome-wide association, Mendelian randomization, and meta-analysis studies. This association is determined by its pro-atherogenic, pro-thrombotic and pro-inflammatory properties. Lp(a) is the most common monogenic risk factor for atherosclerosis, with a prevalence of about 1 in 5 people. Recently, its etiopathogenetic relationship with calcific and degenerative valvular heart diseases, particularly with aortic and mitral stenosis, has been suspected. It has not yet been demonstrated whether its reduction translates into a lower risk of cardiovascular events. Up to now, Lp(a) has been considered a non-modifiable risk factor, as current lipid-lowering drugs have limited effects on its levels. New specific lipid-lowering therapies with high efficacy in reducing circulating Lp(a) levels are being investigated in randomized trials; however, the effects of this reduction on cardiovascular outcomes are still being studied.

Published
2024

6. Management of Metastatic Disease in Campania (MAMETIC): An Observational Multicenter Retrospective and Prospective Trial on Palliative Radiotherapy in an Italian Region. Study Protocol

Author

Di Franco R, Cascella M, Fusco M, Borzillo V, Scipilliti E, Ferraioli P, Iannacone E, De Palma G, Silvestro G, Gherardi F, Buonopane S, Alberti D, Totaro G, Manzo R, Guida G, Cuomo A, Pignata S, Di Napoli M, Rossetti S, Celentano E, Crispo A, Grimaldi M, Ravo V, and Muto P

Subjects
palliative care, metastatic disease, radiotherapy, cancer pain, breakthrough cancer pain, quality of life, Medicine (General), R5-920
Abstract

Rossella Di Franco,1 Marco Cascella,2 Mario Fusco,3 Valentina Borzillo,1 Esmeralda Scipilliti,1 Piera Ferraioli,1 Eva Iannacone,1 Giampaolo De Palma,1 Giustino Silvestro,1 Federica Gherardi,1 Sergio Buonopane,1 Domingo Alberti,1 Giuseppe Totaro,1 Roberto Manzo,1 Giovanna Guida,1 Arturo Cuomo,2 Sandro Pignata,4 Marilena Di Napoli,4 Sabrina Rossetti,4 Egidio Celentano,5 Anna Crispo,5 Maria Grimaldi,5 Vincenzo Ravo,1 Paolo Muto1 1Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia; 2Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Napoli, Italia; 3Cancer Registry Unit, ASL Napoli 3 SUD, Napoli, Italia; 4Department of Uro-Gynecological, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia; 5Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, ItaliaCorrespondence: Rossella Di Franco, Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia, Email r.difranco@istitutotumori.na.itBackground: In the Italian Campania Region, 30.517 new cases of solid cancer have been diagnosed, in 2019. Of those, patients with metastatic disease are up to 20%. This class of patients is extremely diversified and copious, and the offer of radiotherapy may vary in different geographical areas within the same region. The aim of this observational multicenter retrospective and prospective trial is to evaluate the occurrence of metastatic metastatic cancer patients candidates for palliative radiotherapy in several areas of a great Italian region, the management of the disease through RT approaches, and its impact on cancer-related pain and overall HRQoL.Methods: This is a multicenter, retrospective and prospective observational investigation. The retrospective part of the study concerns all patients enrolled with a diagnosis of metastatic disease and treated in RT centers within the Campania Region between January 2019 and July 2020. The prospective phase is going to involve all the metastatic patients with an indication of palliative RT. Considering regional epidemiological data, we expect an enrollment of 12.500– 21.000 patients in 5 years.Conclusion: The MAMETIC Trial in an observational study designed for investigating on the use of radiotherapy in patients with advanced disease within a regional area, and for evaluating the local response to the patient’s request. It can be a unique opportunity, not only to highlight possible geographic differences but also to regularly collect and share data to standardize the therapeutic offer within the regional area. ClinicalTrials.gov ID NCT04595032, retrospectively registered.Keywords: palliative care, metastatic disease, radiotherapy, cancer pain, breakthrough cancer pain, quality of life

Published
2022

8. Impact of different ablation strategies during very high power short duration ablation: insights from the multicentric AIR HPSD registry

Author

Poggi, S, primary, Lepiliier, A, additional, Grimaldi, M, additional, Scaglione, M, additional, Zucchelli, G, additional, Iacopino, S, additional, Rossi, L, additional, Mantovan, R, additional, Pandozzi, C, additional, Giomi, A, additional, Strisciuglio, T, additional, Stabile, G, additional, and Solimene, F, additional

Published
2024
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11. New onset of guttate psoriasis, Hallopeau’s continuous acrodermatitis, and psoriatic arthritis after COVID-19 vaccine

Author

Zoli, A, Peluso, Giusy, Grimaldi, M, De Simone, Clara, D'Agostino, Maria Antonietta, Ortolan, A, Peluso, G, De Simone, C (ORCID:0000-0002-0898-0045), D’Agostino, MA (ORCID:0000-0002-5347-0060), Zoli, A, Peluso, Giusy, Grimaldi, M, De Simone, Clara, D'Agostino, Maria Antonietta, Ortolan, A, Peluso, G, De Simone, C (ORCID:0000-0002-0898-0045), and D’Agostino, MA (ORCID:0000-0002-5347-0060)

Abstract

Not available

Published
2024

16. Intermuscular technique for implantation of the subcutaneous implantable defibrillator: a propensity-matched case-control study

Author

Botto, G, Ziacchi, M, Nigro, G, D'Onofrio, A, Dello Russo, A, Francia, P, Viani, S, Pisano, E, Bisignani, G, Caravati, F, Migliore, F, De Filippo, P, Ottaviano, L, Rordorf, R, Manzo, M, Canevese, F, Lovecchio, M, Valsecchi, S, Checchi, L, Casale, M, Schintu, B, Scalone, A, Tola, G, Setzu, A, Curcio, A, Santoro, A, Baiocchi, C, Gentilini, R, Lunghetti, S, Solimene, F, Shopova, G, Schillaci, V, Arestia, A, Agresta, A, Bianchi, S, Rossi, P, Cauti, F, La Greca, C, Pecora, D, Ammirati, F, Santini, L, Mahfouz, K, Colaiaco, C, Vicentini, A, Savastano, S, Petracci, B, Sanzo, A, Baldi, E, Casula, M, Perego, G, Rella, V, Bianchi, V, Tavoletta, V, De Vivo, S, Palmisano, P, Accogli, M, Milanese, G, Pepi, P, Nicolis, D, Mariani, M, Pagani, M, Bonfantino, M, Caccavo, V, Grimaldi, M, Katsouras, G, Forleo, G, Chieffo, E, Tavarelli, E, Brambilla, R, Pani, A, Giammaria, M, Lucciola, M, Amellone, C, Uran, C, Baroni, M, Ferrari, P, Leidi, C, Drago, F, Silvetti, M, Pazzano, V, Russo, S, Remoli, R, Battipaglia, I, Cazzoli, I, Saputo, F, Devecchi, C, Barbonaglia, L, Viscusi, M, Brignoli, M, Mattera, A, Pedretti, S, Lupi, A, Tommasi, S, Kol, A, Gatto, M, Persi, A, Gonella, A, Rossetti, G, Menardi, E, Rossini, R, Notarstefano, P, Nesti, M, Fraticelli, A, Carreras, G, Donzelli, S, Marini, C, Tordini, A, Lazzari, L, Sartori, P, Di Donna, P, Mascia, G, Capogrosso, P, Magliano, P, Colimodio, M, Sala, S, Mazzone, P, Della Bella, P, Coppolino, A, Arena, G, Borrello, V, Ratti, M, Bartoli, C, Palano, F, Adduci, C, Torriglia, A, Laffi, M, Esposito, C, Giano, A, Franculli, F, Pangallo, A, De Bonis, S, Sarubbi, B, Colonna, D, Correra, A, Romeo, E, Rapacciuolo, A, Liguori, V, Viggiano, A, Strisciullo, T, Biffi, M, Diemberger, I, Martignani, C, Piro, A, Lavalle, C, Magnocavallo, M, Ricciardi, D, Calabrese, V, Gioia, F, Picarelli, F, Licciardello, G, Busacca, G, Calvi, V, Lamberti, F, Lumia, G, Bellini, C, Bianchi, C, Savarese, G, Andreoli, C, Pimpinicchio, L, Pellegrini, D, Giorgi, D, Bovenzi, Busoni, F, Daleffe, E, Facchin, D, Rebellato, L, Stifano, G, Magliano, G, Sergi, D, Barone, L, Morgagni, R, Casella, M, Guerra, F, Cipolletta, L, Molini, S, De Lucia, R, Di Cori, A, Grifoni, G, Paperini, L, Segreti, L, Soldati, E, Zucchelli, G, Russo, V, Rago, A, Ammendola, E, Papa, A, Pieragnoli, P, Ricciardi, G, Perrotta, L, Botto G. L., Ziacchi M., Nigro G., D'Onofrio A., Dello Russo A., Francia P., Viani S., Pisano E., Bisignani G., Caravati F., Migliore F., De Filippo P., Ottaviano L., Rordorf R., Manzo M., Canevese F. L., Lovecchio M., Valsecchi S., Checchi L., Casale M. C., Schintu B., Scalone A., Tola G., Setzu A., Curcio A., Santoro A., Baiocchi C., Gentilini R., Lunghetti S., Solimene F., Shopova G., Schillaci V., Arestia A., Agresta A., Bianchi S., Rossi P., Cauti F. M., La Greca C., Pecora D., Ammirati F., Santini L., Mahfouz K., Colaiaco C., Vicentini A., Savastano S., Petracci B., Sanzo A., Baldi E., Casula M., Perego G. B., Rella V., Bianchi V., Tavoletta V., De Vivo S., Palmisano P., Accogli M., Milanese G., Pepi P., Nicolis D., Mariani M., Pagani M., Bonfantino M. V., Caccavo V., Grimaldi M., Katsouras G., Forleo G. B., Chieffo E., Tavarelli E., Brambilla R., Pani A., Giammaria M., Lucciola M. T., Amellone C., Uran C., Baroni M., Ferrari P., Leidi C., Drago F., Silvetti M. S., Pazzano V., Russo S., Remoli R., Battipaglia I., Cazzoli I., Saputo F., Devecchi C., Barbonaglia L., Viscusi M., Brignoli M., Mattera A., Pedretti S., Lupi A., Tommasi S., Kol A., Gatto M. C., Persi A., Gonella A., Rossetti G., Menardi E., Rossini R., Notarstefano P., Nesti M., Fraticelli A., Carreras G., Donzelli S., Marini C., Tordini A., Lazzari L., Sartori P., Di Donna P., Mascia G., Capogrosso P., Magliano P., Colimodio M., Sala S., Mazzone P., Della Bella P., Coppolino A., Arena G., Borrello V., Ratti M., Bartoli C., Palano F., Adduci C., Torriglia A., Laffi M., Esposito C., Giano A., Franculli F., Pangallo A., De Bonis S., Sarubbi B., Colonna D., Correra A., Romeo E., Rapacciuolo A., Liguori V., Viggiano A., Strisciullo T., Biffi M., Diemberger I., Martignani C., Piro A., Lavalle C., Magnocavallo M., Mariani M. V., Ricciardi D., Calabrese V., Gioia F., Picarelli F., Licciardello G., Busacca G., Calvi V. I., Lamberti F., Lumia G., Bellini C., Bianchi C., Savarese G., Andreoli C., Pimpinicchio L., Pellegrini D., Giorgi D., Busoni F., Daleffe E., Facchin D., Rebellato L., Stifano G., Magliano G., Sergi D., Barone L., Morgagni R., Casella M., Guerra F., Cipolletta L., Molini S., De Lucia R., Di Cori A., Grifoni G., Paperini L., Segreti L., Soldati E., Zucchelli G., Russo V., Rago A., Ammendola E., Papa A., Pieragnoli P., Ricciardi G., Perrotta L., Botto, G, Ziacchi, M, Nigro, G, D'Onofrio, A, Dello Russo, A, Francia, P, Viani, S, Pisano, E, Bisignani, G, Caravati, F, Migliore, F, De Filippo, P, Ottaviano, L, Rordorf, R, Manzo, M, Canevese, F, Lovecchio, M, Valsecchi, S, Checchi, L, Casale, M, Schintu, B, Scalone, A, Tola, G, Setzu, A, Curcio, A, Santoro, A, Baiocchi, C, Gentilini, R, Lunghetti, S, Solimene, F, Shopova, G, Schillaci, V, Arestia, A, Agresta, A, Bianchi, S, Rossi, P, Cauti, F, La Greca, C, Pecora, D, Ammirati, F, Santini, L, Mahfouz, K, Colaiaco, C, Vicentini, A, Savastano, S, Petracci, B, Sanzo, A, Baldi, E, Casula, M, Perego, G, Rella, V, Bianchi, V, Tavoletta, V, De Vivo, S, Palmisano, P, Accogli, M, Milanese, G, Pepi, P, Nicolis, D, Mariani, M, Pagani, M, Bonfantino, M, Caccavo, V, Grimaldi, M, Katsouras, G, Forleo, G, Chieffo, E, Tavarelli, E, Brambilla, R, Pani, A, Giammaria, M, Lucciola, M, Amellone, C, Uran, C, Baroni, M, Ferrari, P, Leidi, C, Drago, F, Silvetti, M, Pazzano, V, Russo, S, Remoli, R, Battipaglia, I, Cazzoli, I, Saputo, F, Devecchi, C, Barbonaglia, L, Viscusi, M, Brignoli, M, Mattera, A, Pedretti, S, Lupi, A, Tommasi, S, Kol, A, Gatto, M, Persi, A, Gonella, A, Rossetti, G, Menardi, E, Rossini, R, Notarstefano, P, Nesti, M, Fraticelli, A, Carreras, G, Donzelli, S, Marini, C, Tordini, A, Lazzari, L, Sartori, P, Di Donna, P, Mascia, G, Capogrosso, P, Magliano, P, Colimodio, M, Sala, S, Mazzone, P, Della Bella, P, Coppolino, A, Arena, G, Borrello, V, Ratti, M, Bartoli, C, Palano, F, Adduci, C, Torriglia, A, Laffi, M, Esposito, C, Giano, A, Franculli, F, Pangallo, A, De Bonis, S, Sarubbi, B, Colonna, D, Correra, A, Romeo, E, Rapacciuolo, A, Liguori, V, Viggiano, A, Strisciullo, T, Biffi, M, Diemberger, I, Martignani, C, Piro, A, Lavalle, C, Magnocavallo, M, Ricciardi, D, Calabrese, V, Gioia, F, Picarelli, F, Licciardello, G, Busacca, G, Calvi, V, Lamberti, F, Lumia, G, Bellini, C, Bianchi, C, Savarese, G, Andreoli, C, Pimpinicchio, L, Pellegrini, D, Giorgi, D, Bovenzi, Busoni, F, Daleffe, E, Facchin, D, Rebellato, L, Stifano, G, Magliano, G, Sergi, D, Barone, L, Morgagni, R, Casella, M, Guerra, F, Cipolletta, L, Molini, S, De Lucia, R, Di Cori, A, Grifoni, G, Paperini, L, Segreti, L, Soldati, E, Zucchelli, G, Russo, V, Rago, A, Ammendola, E, Papa, A, Pieragnoli, P, Ricciardi, G, Perrotta, L, Botto G. L., Ziacchi M., Nigro G., D'Onofrio A., Dello Russo A., Francia P., Viani S., Pisano E., Bisignani G., Caravati F., Migliore F., De Filippo P., Ottaviano L., Rordorf R., Manzo M., Canevese F. L., Lovecchio M., Valsecchi S., Checchi L., Casale M. C., Schintu B., Scalone A., Tola G., Setzu A., Curcio A., Santoro A., Baiocchi C., Gentilini R., Lunghetti S., Solimene F., Shopova G., Schillaci V., Arestia A., Agresta A., Bianchi S., Rossi P., Cauti F. M., La Greca C., Pecora D., Ammirati F., Santini L., Mahfouz K., Colaiaco C., Vicentini A., Savastano S., Petracci B., Sanzo A., Baldi E., Casula M., Perego G. B., Rella V., Bianchi V., Tavoletta V., De Vivo S., Palmisano P., Accogli M., Milanese G., Pepi P., Nicolis D., Mariani M., Pagani M., Bonfantino M. V., Caccavo V., Grimaldi M., Katsouras G., Forleo G. B., Chieffo E., Tavarelli E., Brambilla R., Pani A., Giammaria M., Lucciola M. T., Amellone C., Uran C., Baroni M., Ferrari P., Leidi C., Drago F., Silvetti M. S., Pazzano V., Russo S., Remoli R., Battipaglia I., Cazzoli I., Saputo F., Devecchi C., Barbonaglia L., Viscusi M., Brignoli M., Mattera A., Pedretti S., Lupi A., Tommasi S., Kol A., Gatto M. C., Persi A., Gonella A., Rossetti G., Menardi E., Rossini R., Notarstefano P., Nesti M., Fraticelli A., Carreras G., Donzelli S., Marini C., Tordini A., Lazzari L., Sartori P., Di Donna P., Mascia G., Capogrosso P., Magliano P., Colimodio M., Sala S., Mazzone P., Della Bella P., Coppolino A., Arena G., Borrello V., Ratti M., Bartoli C., Palano F., Adduci C., Torriglia A., Laffi M., Esposito C., Giano A., Franculli F., Pangallo A., De Bonis S., Sarubbi B., Colonna D., Correra A., Romeo E., Rapacciuolo A., Liguori V., Viggiano A., Strisciullo T., Biffi M., Diemberger I., Martignani C., Piro A., Lavalle C., Magnocavallo M., Mariani M. V., Ricciardi D., Calabrese V., Gioia F., Picarelli F., Licciardello G., Busacca G., Calvi V. I., Lamberti F., Lumia G., Bellini C., Bianchi C., Savarese G., Andreoli C., Pimpinicchio L., Pellegrini D., Giorgi D., Busoni F., Daleffe E., Facchin D., Rebellato L., Stifano G., Magliano G., Sergi D., Barone L., Morgagni R., Casella M., Guerra F., Cipolletta L., Molini S., De Lucia R., Di Cori A., Grifoni G., Paperini L., Segreti L., Soldati E., Zucchelli G., Russo V., Rago A., Ammendola E., Papa A., Pieragnoli P., Ricciardi G., and Perrotta L.

Abstract

Aims A previous randomized study demonstrated that the subcutaneous implantable cardioverter defibrillator (S-ICD) was noninferior to transvenous ICD with respect to device-related complications and inappropriate shocks. However, that was performed prior to the widespread adoption of pulse generator implantation in the intermuscular (IM) space instead of the traditional subcutaneous (SC) pocket. The aim of this analysis was to compare survival from device-related complications and inappropriate shocks between patients who underwent S-ICD implantation with the generator positioned in an IM position in comparison with an SC pocket. Methods and results We analysed 1577 consecutive patients who had undergone S-ICD implantation from 2013 to 2021 and were followed up until December 2021. Subcutaneous patients (n = 290) were propensity matched with patients of the IM group (n = 290), and their outcomes were compared. : During a median follow-up of 28 months, device-related complications were reported in 28 (4.8%) patients and inappropriate shocks were reported in 37 (6.4%) patients. The risk of complication was lower in the matched IM group than in the SC group [hazard ratio 0.41, 95% confidence interval (CI) 0.17-0.99, P = 0.041], as well as the composite of complications and inappropriate shocks (hazard ratio 0.50, 95% CI 0.30-0.86, P = 0.013). The risk of appropriate shocks was similar between groups (hazard ratio 0.90, 95% CI 0.50-1.61, P = 0.721). There was no significant interaction between generator positioning and variables such as gender, age, body mass index, and ejection fraction. Conclusion Our data showed the superiority of the IM S-ICD generator positioning in reducing device-related complications and inappropriate shocks.

Published
2023

17. Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular prevention

Author

Baldassarre, D, Iacoviello, L, Baetta, R, Roncaglioni, M, Condorelli, G, Remuzzi, G, Gensini, G, Frati, L, Ricciardi, W, Conaldi, P, Uccelli, A, Blandini, F, Bosari, S, Scambia, G, Fini, M, Di Malta, A, Amato, M, Veglia, F, Bonomi, A, Klersy, C, Colazzo, F, Pengo, M, Gorini, F, Auteri, L, Ferrante, G, Baviera, M, Ambrosio, G, Catapano, A, Gialluisi, A, Malavazos, A, Castelvecchio, S, Corsi-Romanelli, M, Cardani, R, La Rovere, M, Agnese, V, Pane, B, Prati, D, Spinardi, L, Liuzzo, G, Arbustini, E, Volterrani, M, Visconti, M, Werba, J, Genovese, S, Bilo, G, Invitti, C, Di Blasio, A, Lombardi, C, Faini, A, Rosa, D, Ojeda-Fernandez, L, Foresta, A, De Curtis, A, Di Castelnuovo, A, Scalvini, S, Pierobon, A, Gorini, A, Valenti, L, Luzi, L, Racca, A, Bandi, M, Tremoli, E, Menicanti, L, Parati, G, Pompilio, G, Colombo, G, Vavassori, C, Biondi, M, Frigerio, B, Ravani, A, Sansaro, D, Coggi, D, Romandini, A, Giroli, M, Giuliani, M, Bonmi, A, Rondinelli, M, Trudu, C, Cinieri, C, Monturano, M, Colazo, F, Inviti, C, Di Blasi, A, Torlasco, C, Gilardini, L, Soranna, D, Zambon, A, Perger, E, Zanotti, L, Badano, L, Cova, L, Gentilini, D, Grappiolo, L, Condoreli, G, Ferante, G, Papa, L, Savevski, V, Ieva, F, Romano, I, Remzzi, G, Ojeda, L, Clerici, F, Palumbo, A, Genini, G, Catpano, A, Mattioli, R, Longhi, E, Mantovani, L, Madotto, F, Bonaccio, M, Gianfagna, F, Ghulam, A, Magnacca, S, Noro, F, Costanzo, S, Esposito, S, Orlandi, S, Persichillo, M, Bracone, F, Panzera, T, Ruggiero, E, Parisi, R, Franciosa, S, Morelli, M, De Rita, F, Cerletti, C, de Gaetano, G, Donati, M, Mencanti, L, Romanelli, M, Cerri, A, Dubini, C, Trevisan, M, Renna, L, Milani, V, Boveri, S, Giubbilini, P, Ramputi, L, Baroni, I, De Angeli, G, Riciardi, W, Olmetti, F, Bussotti, M, Gaetano, C, Baiardi, P, Bachetti, T, Balbi, M, Comini, L, Lorenzoni, M, Olivares, A, Traversi, E, Garre, C, Sideri, R, Clemenza, F, Gentile, G, Caruana, G, Cuscino, N, Di Gesaro, G, Greco, A, Loddo, I, Tuzzolino, F, Ucelli, A, Palombo, D, Spinella, G, Mozzetta, G, Ameri, P, Zoppoli, G, Finotello, A, Porto, I, Pratesi, G, Bladini, F, Spnardi, L, Clerici, M, Pelusi, S, Bianco, C, Carpani, R, Periti, G, Margarita, S, Lanza, G, Severino, A, Pedicino, D, D'Amario, D, D'Aiello, A, Vinci, R, Bonanni, A, Brecciaroli, M, Filomia, S, Pastorino, R, Boccia, S, Urbani, A, Sanguinetti, M, Santoliquido, A, Proto, L, Tarquini, D, Grimaldi, M, Leonardi, S, Elia, A, Currao, A, Urtis, M, Di Toro, A, Giuliani, L, Caminiti, G, Marcolongo, F, Sposato, B, Guadagni, F, Morsella, V, Marziale, A, Protti, G, Baldassarre D., Iacoviello L., Baetta R., Roncaglioni M. C., Condorelli G., Remuzzi G., Gensini G., Frati L., Ricciardi W., Conaldi P. G., Uccelli A., Blandini F., Bosari S., Scambia G., Fini M., Di Malta A., Amato M., Veglia F., Bonomi A., Klersy C., Colazzo F., Pengo M., Gorini F., Auteri L., Ferrante G., Baviera M., Ambrosio G., Catapano A., Gialluisi A., Malavazos A. E., Castelvecchio S., Corsi-Romanelli M. M., Cardani R., La Rovere M. T., Agnese V., Pane B., Prati D., Spinardi L., Liuzzo G., Arbustini E., Volterrani M., Visconti M., Werba J. P., Genovese S., Bilo G., Invitti C., Di Blasio A., Lombardi C., Faini A., Rosa D., Ojeda-Fernandez L., Foresta A., De Curtis A., Di Castelnuovo A., Scalvini S., Pierobon A., Gorini A., Valenti L., Luzi L., Racca A., Bandi M., Tremoli E., Menicanti L., Parati G., Pompilio G., Colombo G., Vavassori C., Biondi M. L., Frigerio B., Ravani A., Sansaro D., Coggi D., Romandini A., Giroli M., Giuliani M., Bonmi A., Rondinelli M., Trudu C., Cinieri C., Monturano M., Colazo F., Inviti C., Di Blasi A., Torlasco C., Gilardini L., Soranna D., Zambon A., Perger E., Zanotti L., Badano L., Cova L., Gentilini D., Grappiolo L., Condoreli G., Ferante G., Papa L., Savevski V., Ieva F., Romano I., Remzzi G., Ojeda L., Clerici F., Palumbo A., Genini G. F., Catpano A., Mattioli R., Longhi E., Mantovani L. G., Madotto F., Bonaccio M., Gianfagna F., Ghulam A., Magnacca S., Noro F., Costanzo S., Esposito S., Orlandi S., Persichillo M., Bracone F., Panzera T., Ruggiero E., Parisi R., Franciosa S., Morelli M., De Rita F., Cerletti C., de Gaetano G., Donati M. B., Mencanti L., Romanelli M. M. C., Cerri A., Dubini C., Trevisan M. B., Renna L. V., Milani V., Boveri S., Giubbilini P., Ramputi L., Baroni I., De Angeli G., Riciardi W., Olmetti F., Bussotti M., Gaetano C., Baiardi P., Bachetti T., Balbi M., Comini L., Lorenzoni M., Olivares A., Traversi E., Garre C., Sideri R., Clemenza F., Gentile G., Caruana G., Cuscino N., Di Gesaro G., Greco A., Loddo I., Tuzzolino F., Ucelli A., Palombo D., Spinella G., Mozzetta G., Ameri P., Zoppoli G., Finotello A., Porto I., Pratesi G., Bladini F., Spnardi L., Clerici M., Pelusi S., Bianco C., Carpani R., Periti G., Margarita S., Lanza G. A., Severino A., Pedicino D., D'Amario D., D'Aiello A., Vinci R., Bonanni A., Brecciaroli M., Filomia S., Pastorino R., Boccia S., Urbani A., Sanguinetti M., Santoliquido A., Proto L., Tarquini D., Grimaldi M. C., Leonardi S., Elia A., Currao A., Urtis M., Di Toro A., Giuliani L., Caminiti G., Marcolongo F., Sposato B., Guadagni F., Morsella V., Marziale A., Protti G., Baldassarre, D, Iacoviello, L, Baetta, R, Roncaglioni, M, Condorelli, G, Remuzzi, G, Gensini, G, Frati, L, Ricciardi, W, Conaldi, P, Uccelli, A, Blandini, F, Bosari, S, Scambia, G, Fini, M, Di Malta, A, Amato, M, Veglia, F, Bonomi, A, Klersy, C, Colazzo, F, Pengo, M, Gorini, F, Auteri, L, Ferrante, G, Baviera, M, Ambrosio, G, Catapano, A, Gialluisi, A, Malavazos, A, Castelvecchio, S, Corsi-Romanelli, M, Cardani, R, La Rovere, M, Agnese, V, Pane, B, Prati, D, Spinardi, L, Liuzzo, G, Arbustini, E, Volterrani, M, Visconti, M, Werba, J, Genovese, S, Bilo, G, Invitti, C, Di Blasio, A, Lombardi, C, Faini, A, Rosa, D, Ojeda-Fernandez, L, Foresta, A, De Curtis, A, Di Castelnuovo, A, Scalvini, S, Pierobon, A, Gorini, A, Valenti, L, Luzi, L, Racca, A, Bandi, M, Tremoli, E, Menicanti, L, Parati, G, Pompilio, G, Colombo, G, Vavassori, C, Biondi, M, Frigerio, B, Ravani, A, Sansaro, D, Coggi, D, Romandini, A, Giroli, M, Giuliani, M, Bonmi, A, Rondinelli, M, Trudu, C, Cinieri, C, Monturano, M, Colazo, F, Inviti, C, Di Blasi, A, Torlasco, C, Gilardini, L, Soranna, D, Zambon, A, Perger, E, Zanotti, L, Badano, L, Cova, L, Gentilini, D, Grappiolo, L, Condoreli, G, Ferante, G, Papa, L, Savevski, V, Ieva, F, Romano, I, Remzzi, G, Ojeda, L, Clerici, F, Palumbo, A, Genini, G, Catpano, A, Mattioli, R, Longhi, E, Mantovani, L, Madotto, F, Bonaccio, M, Gianfagna, F, Ghulam, A, Magnacca, S, Noro, F, Costanzo, S, Esposito, S, Orlandi, S, Persichillo, M, Bracone, F, Panzera, T, Ruggiero, E, Parisi, R, Franciosa, S, Morelli, M, De Rita, F, Cerletti, C, de Gaetano, G, Donati, M, Mencanti, L, Romanelli, M, Cerri, A, Dubini, C, Trevisan, M, Renna, L, Milani, V, Boveri, S, Giubbilini, P, Ramputi, L, Baroni, I, De Angeli, G, Riciardi, W, Olmetti, F, Bussotti, M, Gaetano, C, Baiardi, P, Bachetti, T, Balbi, M, Comini, L, Lorenzoni, M, Olivares, A, Traversi, E, Garre, C, Sideri, R, Clemenza, F, Gentile, G, Caruana, G, Cuscino, N, Di Gesaro, G, Greco, A, Loddo, I, Tuzzolino, F, Ucelli, A, Palombo, D, Spinella, G, Mozzetta, G, Ameri, P, Zoppoli, G, Finotello, A, Porto, I, Pratesi, G, Bladini, F, Spnardi, L, Clerici, M, Pelusi, S, Bianco, C, Carpani, R, Periti, G, Margarita, S, Lanza, G, Severino, A, Pedicino, D, D'Amario, D, D'Aiello, A, Vinci, R, Bonanni, A, Brecciaroli, M, Filomia, S, Pastorino, R, Boccia, S, Urbani, A, Sanguinetti, M, Santoliquido, A, Proto, L, Tarquini, D, Grimaldi, M, Leonardi, S, Elia, A, Currao, A, Urtis, M, Di Toro, A, Giuliani, L, Caminiti, G, Marcolongo, F, Sposato, B, Guadagni, F, Morsella, V, Marziale, A, Protti, G, Baldassarre D., Iacoviello L., Baetta R., Roncaglioni M. C., Condorelli G., Remuzzi G., Gensini G., Frati L., Ricciardi W., Conaldi P. G., Uccelli A., Blandini F., Bosari S., Scambia G., Fini M., Di Malta A., Amato M., Veglia F., Bonomi A., Klersy C., Colazzo F., Pengo M., Gorini F., Auteri L., Ferrante G., Baviera M., Ambrosio G., Catapano A., Gialluisi A., Malavazos A. E., Castelvecchio S., Corsi-Romanelli M. M., Cardani R., La Rovere M. T., Agnese V., Pane B., Prati D., Spinardi L., Liuzzo G., Arbustini E., Volterrani M., Visconti M., Werba J. P., Genovese S., Bilo G., Invitti C., Di Blasio A., Lombardi C., Faini A., Rosa D., Ojeda-Fernandez L., Foresta A., De Curtis A., Di Castelnuovo A., Scalvini S., Pierobon A., Gorini A., Valenti L., Luzi L., Racca A., Bandi M., Tremoli E., Menicanti L., Parati G., Pompilio G., Colombo G., Vavassori C., Biondi M. L., Frigerio B., Ravani A., Sansaro D., Coggi D., Romandini A., Giroli M., Giuliani M., Bonmi A., Rondinelli M., Trudu C., Cinieri C., Monturano M., Colazo F., Inviti C., Di Blasi A., Torlasco C., Gilardini L., Soranna D., Zambon A., Perger E., Zanotti L., Badano L., Cova L., Gentilini D., Grappiolo L., Condoreli G., Ferante G., Papa L., Savevski V., Ieva F., Romano I., Remzzi G., Ojeda L., Clerici F., Palumbo A., Genini G. F., Catpano A., Mattioli R., Longhi E., Mantovani L. G., Madotto F., Bonaccio M., Gianfagna F., Ghulam A., Magnacca S., Noro F., Costanzo S., Esposito S., Orlandi S., Persichillo M., Bracone F., Panzera T., Ruggiero E., Parisi R., Franciosa S., Morelli M., De Rita F., Cerletti C., de Gaetano G., Donati M. B., Mencanti L., Romanelli M. M. C., Cerri A., Dubini C., Trevisan M. B., Renna L. V., Milani V., Boveri S., Giubbilini P., Ramputi L., Baroni I., De Angeli G., Riciardi W., Olmetti F., Bussotti M., Gaetano C., Baiardi P., Bachetti T., Balbi M., Comini L., Lorenzoni M., Olivares A., Traversi E., Garre C., Sideri R., Clemenza F., Gentile G., Caruana G., Cuscino N., Di Gesaro G., Greco A., Loddo I., Tuzzolino F., Ucelli A., Palombo D., Spinella G., Mozzetta G., Ameri P., Zoppoli G., Finotello A., Porto I., Pratesi G., Bladini F., Spnardi L., Clerici M., Pelusi S., Bianco C., Carpani R., Periti G., Margarita S., Lanza G. A., Severino A., Pedicino D., D'Amario D., D'Aiello A., Vinci R., Bonanni A., Brecciaroli M., Filomia S., Pastorino R., Boccia S., Urbani A., Sanguinetti M., Santoliquido A., Proto L., Tarquini D., Grimaldi M. C., Leonardi S., Elia A., Currao A., Urtis M., Di Toro A., Giuliani L., Caminiti G., Marcolongo F., Sposato B., Guadagni F., Morsella V., Marziale A., and Protti G.

Abstract

Introduction Prevention of cardiovascular disease (CVD) is of key importance in reducing morbidity, disability and mortality worldwide. Observational studies suggest that digital health interventions can be an effective strategy to reduce cardiovascular (CV) risk. However, evidence from large randomised clinical trials is lacking. Methods and analysis The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial designed to compare the effectiveness of an educational and motivational mobile health (mHealth) intervention versus usual care in reducing CV risk. The intervention aims at improving diet, physical activity, sleep quality, psycho-behavioural aspects, as well as promoting smoking cessation and adherence to pharmacological treatment for CV risk factors. The trial aims to enrol approximately 80 000 subjects without overt CVDs referring to general practitioners' offices, community pharmacies or clinics of Scientific Institute for Research, Hospitalization and Health Care (Italian acronym IRCCS) affiliated with the Italian Cardiology Network. All participants are evaluated at baseline and after 12 months to assess the effectiveness of the intervention on short-term endpoints, namely improvement in CV risk score and reduction of major CV risk factors. Beyond the funded life of the study, a long-term (7 years) follow-up is also planned to assess the effectiveness of the intervention on the incidence of major adverse CV events. A series of ancillary studies designed to evaluate the effect of the mHealth intervention on additional risk biomarkers are also performed. Ethics and dissemination This study received ethics approval from the ethics committee of the coordinating centre (Monzino Cardiology Center; R1256/20-CCM 1319) and from all other relevant IRBs and ethics committees. Findings are disseminated through scientific meetings and peer-reviewed journals and via social media. Partners are informed about the study's

Published
2023

18. Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios

Author

Luca, F, Oliva, F, Abrignani, M, Di Fusco, S, Parrini, I, Canale, M, Giubilato, S, Cornara, S, Nesti, M, Rao, C, Pozzi, A, Binaghi, G, Maloberti, A, Ceravolo, R, Bisceglia, I, Rossini, R, Temporelli, P, Amico, A, Calvanese, R, Gelsomino, S, Riccio, C, Grimaldi, M, Colivicchi, F, Gulizia, M, Luca F., Oliva F., Abrignani M. G., Di Fusco S. A., Parrini I., Canale M. L., Giubilato S., Cornara S., Nesti M., Rao C. M., Pozzi A., Binaghi G., Maloberti A., Ceravolo R., Bisceglia I., Rossini R., Temporelli P. L., Amico A. F., Calvanese R., Gelsomino S., Riccio C., Grimaldi M., Colivicchi F., Gulizia M. M., Luca, F, Oliva, F, Abrignani, M, Di Fusco, S, Parrini, I, Canale, M, Giubilato, S, Cornara, S, Nesti, M, Rao, C, Pozzi, A, Binaghi, G, Maloberti, A, Ceravolo, R, Bisceglia, I, Rossini, R, Temporelli, P, Amico, A, Calvanese, R, Gelsomino, S, Riccio, C, Grimaldi, M, Colivicchi, F, Gulizia, M, Luca F., Oliva F., Abrignani M. G., Di Fusco S. A., Parrini I., Canale M. L., Giubilato S., Cornara S., Nesti M., Rao C. M., Pozzi A., Binaghi G., Maloberti A., Ceravolo R., Bisceglia I., Rossini R., Temporelli P. L., Amico A. F., Calvanese R., Gelsomino S., Riccio C., Grimaldi M., Colivicchi F., and Gulizia M. M.

Abstract

It is well established that direct oral anticoagulants (DOACs) are the cornerstone of anticoagulant strategy in atrial fibrillation (AF) and venous thromboembolism (VTE) and should be preferred over vitamin K antagonists (VKAs) since they are superior or non-inferior to VKAs in reducing thromboembolic risk and are associated with a lower risk of intracranial hemorrhage (IH). In addition, many factors, such as fewer pharmacokinetic interactions and less need for monitoring, contribute to the favor of this therapeutic strategy. Although DOACs represent a more suitable option, several issues should be considered in clinical practice, including drug–drug interactions (DDIs), switching to other antithrombotic therapies, preprocedural and postprocedural periods, and the use in patients with chronic renal and liver failure and in those with cancer. Furthermore, adherence to DOACs appears to remain suboptimal. This narrative review aims to provide a practical guide for DOAC prescription and address challenging scenarios.

Published
2023

19. The processing of Which interrogative sentences: A behavioral and ERP study

Author

Grimaldi, M, De Vincenzi, M, Lorusso, P, Di Russo, F, Di Matteo, R, Rizzi, L, Guasti, M, Grimaldi M., De Vincenzi M., Lorusso P., Di Russo F., Di Matteo R., Rizzi L., Guasti M. T., Grimaldi, M, De Vincenzi, M, Lorusso, P, Di Russo, F, Di Matteo, R, Rizzi, L, Guasti, M, Grimaldi M., De Vincenzi M., Lorusso P., Di Russo F., Di Matteo R., Rizzi L., and Guasti M. T.

Abstract

This study investigates the parsing of Italian Wh-questions of the Which-N type. The extraction site could be either the subject or the object noun phrase. The verb following the Which-noun was either a singular or a plural form, immediately disambiguating the Which-N argument role through verb agreement. Reading time on the verb and on the post-verbal noun phrase were significantly shorter for the subject Wh-question than for the object Wh-question. Multi-channel ERP data showed increased P600 amplitudes for the object questions in response to the critical word on the left temporal lobe in the superior temporal gyrus. These findings are in line with the Minimal Chain Principle (De Vincenzi, 1991a) and provide further evidence for the hypothesis that the amplitude and duration of the P600 involve multi-dimensional processes controlling operations such as prediction, retrieval, revising, and structure-building operations needed for assembly (and disassembly) of syntactic relations.

Published
2023

20. Molybdenum sputtering film characterization for high gradient accelerating structures

Author

Bini, S., Spataro, B., Marcelli, A., Sarti, S., Dolgashev, V. A., Tantawi, S., Yeremian, A. D., Higashi, Y., Grimaldi, M. G., Romano, L., Ruffino, F., Parodi, R., Cibin, G., Marrelli, C., Migliorati, M., and Caliendo, C.

Subjects
Physics - Accelerator Physics, Condensed Matter - Materials Science
Abstract

Technological advancements are strongly required to fulfill the demands of new accelerator devices with the highest accelerating gradients and operation reliability for the future colliders. To this purpose an extensive R&D regarding molybdenum coatings on copper is in progress. In this contribution we describe chemical composition, deposition quality and resistivity properties of different molybdenum coatings obtained via sputtering. The deposited films are thick metallic disorder layers with different resistivity values above and below the molibdenum dioxide reference value. Chemical and electrical properties of these sputtered coatings have been characterized by Rutherford backscattering, XANES and photoemission spectroscopy. We will also present a three cells standing wave section coated by a molybdenum layer $\sim$ 500 nm thick designed to improve the performance of X-Band accelerating systems., Comment: manuscript has been submitted and accepted by Chinese Physics C (2012)

Published
2012
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22. Biological profiling in the spectrum of acute coronary syndrome: characterizing patients from MINOCA to NSTEMI with different features of the culprit plaque

Author

D'aiello, A, primary, Pedicino, D, additional, Bonanni, A, additional, Vinci, R, additional, Severino, A, additional, Ponzo, M, additional, Conte, C, additional, Cribari, F, additional, Filomia, S, additional, Brecciaroli, M, additional, Grimaldi, M C, additional, Montone, R A, additional, Massetti, M, additional, Crea, F, additional, and Liuzzo, G, additional

Published
2023
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24. STEREOTACTIC ARRHYTHMIA RADIOABLATION OF PAROXYSMAL ATRIAL FIBRILLATION –STATE OF ART AND FUTURE DIRECTION

Author

Bonaparte, I., primary, Gregucci, F., additional, Dimonaco, A., additional, Surgo, A., additional, Ludovico, E., additional, Carbonara, R., additional, Paulicelli, E., additional, Sanfrancesco, G., additional, Depascali, C., additional, Ciliberti, M.P., additional, Calbi, R., additional, Grimaldi, M., additional, and Fiorentino, A., additional

Published
2023
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25. A novel hemodynamic index characterizing mitral regurgitation undergoing transcatheter edge to edge repair: the mitral pulse pressure fraction

Author

Leone, A M, primary, Di Giusto, F, additional, Lucarelli, K, additional, Vicere, A, additional, Anastasia, G, additional, Galante, D, additional, Petrolati, E, additional, Burzotta, F, additional, Aurigemma, C, additional, Lombardo, A, additional, Locorotondo, G, additional, Graziani, F, additional, Casamassima, V, additional, Grimaldi, M, additional, and Trani, C, additional

Published
2023
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29. P13-035-23 Ultra-Processed Foods and Cardiovascular Risk Factors in Women With Breast Cancer Living in a Mediterranean Area: A Baseline Cross-Sectional Analysis of DEDiCa Trial

Author

Palumbo, Elvira, primary, Vitale, S., additional, Turati, F., additional, Porciello, G., additional, Luongo, A., additional, Grimaldi, M., additional, Pica, R., additional, Calabrese, I., additional, Minopoli, A., additional, Grilli, B., additional, Fiorillo, P.C., additional, Cavalcanti, E., additional, De Laurentiis, M., additional, Riccardi, G., additional, Jenkins, D.J.A., additional, Crispo, A., additional, Celentano, E., additional, La Vecchia, C., additional, and Augustin, L.S.A., additional

Published
2023
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30. MOLECULAR SUBTYPES AND DIETARY PATTERNS IN BREAST CANCER PATIENTS: A LATENT CLASS ANALYSIS

Author

Crispo, A., primary, Coluccia, S., additional, Vitale, S., additional, Palumbo, E., additional, Porciello, G., additional, Luongo, A., additional, Prete, M., additional, Coppola, E., additional, Montagnese, C., additional, Di Gennaro, P., additional, Grimaldi, M., additional, Pica, R., additional, Rotondo, E., additional, Celentano, E., additional, Izzo, F., additional, Amore, A., additional, Cascella, M., additional, Perri, F., additional, De Laurentiis, M., additional, and Augustin, L.S.A., additional

Published
2023
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38. PO-1611 Paroxysmal atrial fibrillation in elderly: linac-based sbrt arrhythmia radioablation phase 2 trial

Author

Gregucci, F., primary, Di Monaco, A., additional, Bonaparte, I., additional, Surgo, A., additional, Carbonara, R., additional, Ciliberti, M.P., additional, Di Guglielmo, F., additional, Caliandro, M., additional, Paulicelli, E., additional, Ludovico, E., additional, Romanazzi, I., additional, Grimaldi, M., additional, and Fiorentino, A., additional

Published
2023
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39. PO-2283 Analysis of target motion in STereotactic Arrhythmia Radioablation for atrial fibrillation

Author

Di Guglielmo, F.C., primary, Sanfrancesco, G., additional, De Pascali, C., additional, Gregucci, F., additional, Surgo, A., additional, Carbonara, R., additional, Ciliberti, M.P., additional, Caliandro, M., additional, Paulicelli, E., additional, Romanazzo, I., additional, Di Monaco, A., additional, Grimaldi, M., additional, Bonaparte, I., additional, and Fiorentino, A., additional

Published
2023
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41. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, and Sperandeo, Marco

Abstract

Objectives: We validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose. Methods: From July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan. Results: On a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity

Published
2023

44. Thermodynamic Properties of Supported and Embedded Metallic Nanocrystals: Gold on/in SiO2

Author

Ruffino, F., Grimaldi, M., Giannazzo, F., Roccaforte, F., and Raineri, V.

Abstract

Abstract: We report on the calculations of the cohesive energy, melting temperature and vacancy formation energy for Au nanocrystals with different size supported on and embedded in SiO2. The calculations are performed crossing our previous data on the surface free energy of the supported and embedded nanocrystals with the theoretical surface-area-difference model developed by W. H. Qi for the description of the size-dependent thermodynamics properties of low-dimensional solid-state systems. Such calculations are employed as a function of the nanocrystals size and surface energy. For nanocrystals supported on SiO2, as results of the calculations, we obtain, for a fixed nanocrystal size, an almost constant cohesive energy, melting temperature and vacancy formation energy as a function of their surface energy; instead, for those embedded in SiO2, they decreases when the nanocrystal surface free energy increases. Furthermore, the cohesive energy, melting temperature and vacancy formation energy increase when the nanocrystal size increases: for the nanocrystals on SiO2, they tend to the values of the bulk Au; for the nanocrystals in SiO2 in correspondence to sufficiently small values of their surface energy, they are greater than the bulk values. In the case of the melting temperature, this phenomenon corresponds to the experimentally well-known superheating process.

Published
2024
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46. A GIS-BIM Approach for the Evaluation of Urban Transformations. A Methodological Proposal

Author

Grimaldi, M., Giordano, C., Graziuso, G., Barba, S., and Fasolino, I.

Subjects
Urban Plan, GIS, BIM, urban indicators, urban transformations evaluation, General Energy, Urban Plan, urban transformations evaluation, Geography, Planning and Development, BIM, GIS, urban indicators, General Environmental Science
Abstract

The implementation and monitoring of the urban transformations provided by the planning tools require a control by the responsible territorial authorities on the compliance of the proposed transformations with the technical and binding rules of the current plans. Considering the complexity of the urban and territorial scale, professionals need a tool capable of satisfying the planning, design and management needs of urban space. The large amount of data and the possibilities of managing the multiple information contained in a BIM model can, indeed, be integrated usefully and declined at higher scales than the single building one, since they can be extended from the sphere of pure architectural design to planning sector. In such a wide context, the GIS-BIM approach can represent a real shift of paradigm aimed at managing the complexity of urban processes more effectively.

Published
2022
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47. Modulation of the gut microbiota composition by rifaximin in non-constipated irritable bowel syndrome patients: a molecular approach

Author

Soldi S, Vasileiadis S, Uggeri F, Campanale M, Morelli L, Fogli MV, Calanni F, Grimaldi M, and Gasbarrini A

Subjects
IBS, rifaximin, Next Generation Sequencing, microbiota, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Sara Soldi,1 Sotirios Vasileiadis,2 Francesca Uggeri,1 Mariachiara Campanale,3 Lorenzo Morelli,4 Maria Vittoria Fogli,5 Fiorella Calanni,5 Maria Grimaldi,5 Antonio Gasbarrini31AAT – Advanced Analytical Technologies Srl, Piacenza, Italy; 2Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, Australia; 3Internal Medicine and Gastroenterology Division, Catholic University of Rome, Rome, Italy; 4Microbiology Institute, Catholic University of Piacenza, Piacenza, Italy; 5Alfa Wassermann SpA, Bologna, ItalyAbstract: Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota. The aim of the present study was to assess, by biomolecular tools, the rifaximin active modulation exerted on gut microbiota of non-constipated IBS patients. Fifteen non-constipated IBS subjects were treated with 550 mg rifaximin three times a day for 14 days. Stool samples were collected before starting the treatment, at the end of it, and after a 6-week washout period. Real-time polymerase chain reaction, denaturing gradient gel electrophoresis, and next-generation sequencing were applied to all the samples to verify and quantify possible microbial fluctuations. Rifaximin treatment did not affect the overall composition of the microbiota of the treated subjects, inducing fluctuations in few bacterial groups, balanced by the replacement of homologs or complementary bacterial groups. Rifaximin appeared to influence mainly potentially detrimental bacteria, such as Clostridium, but increasing the presence of some species, such as Faecalibacterium prausnitzii. A decrease in the Firmicutes/Bacteroidetes ratio after 14 days of treatment and bacterial profiles with higher biodiversity were observed during the follow-up compared to baseline. Rifaximin treatment, although effective on IBS symptom relief and normalization of lactulose breath test, did not induce dramatic shifts in the microbiota composition of the subjects, stimulating microbial reorganization in some populations toward a more diverse composition. It was not possible to speculate on differences of fecal microbiota modification between responders vs nonresponders and to correlate the quali-/quantitative modification of upper gastrointestinal microbiota and clinical response.Keywords: IBS, rifaximin, next-generation sequencing, microbiota

Published
2015

48. Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study

Author

Bomba M, Riva A, Morzenti S, Grimaldi M, Neri F, and Nacinovich R

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Monica Bomba,1,* Anna Riva,1,* Sabrina Morzenti,2 Marco Grimaldi,3 Francesca Neri,1 Renata Nacinovich1 1Child and Adolescent Mental Health Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy; 2Medical Physics Department, San Gerardo Hospital, Monza, Italy; 3Department of Radiology, Humanitas Research Hospital, Milan, Italy *These authors contributed equally to this work Abstract: The recent literature on anorexia nervosa (AN) suggests that functional and structural abnormalities of cortico-limbic areas might play a role in the evolution of the disease. We explored global and regional brain volumes in a cross-sectional and follow-up study on adolescents affected by AN. Eleven adolescents with AN underwent a voxel-based morphometry study at time of diagnosis and immediately after weight recovery. Data were compared to volumes carried out in eight healthy, age and sex matched controls. Subjects with AN showed increased cerebrospinal fluid volumes and decreased white and gray matter volumes, when compared to controls. Moreover, significant regional gray matter decrease in insular cortex and cerebellum was found at time of diagnosis. No regional white matter decrease was found between samples and controls. Correlations between psychological evaluation and insular volumes were explored. After weight recovery gray matter volumes normalized while reduced global white matter volumes persisted. Keywords: anorexia nervosa, adolescent, gray matter, insula, voxel-based morphometry study

Published
2015

49. Paroxysmal Atrial Fibrillation in Elderly: Worldwide Preliminary Data of Linac-Based Stereotactic Arrhythmia Radioablation Prospective Phase II Trial

Author

Gregucci, F., primary, Di Monaco, A., additional, Bonaparte, I., additional, Surgo, A., additional, Troisi, F., additional, Ludovico, E., additional, Vitulano, N., additional, Quadrini, F., additional, Carbonara, R., additional, Ciliberti, M.P., additional, Grimaldi, M., additional, and Fiorentino, A., additional

Published
2022
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