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3. Identification and bioinformatic characterization of a serum miRNA signature for early detection of laryngeal squamous cell carcinoma

Author

Falco, Michela, Tammaro, Chiara, Cossu, Alessia Maria, Takeuchi, Takashi, Tufano, Rossella, Ceccarelli, Michele, Scafuro, Giuseppe, Zappavigna, Silvia, Grimaldi, Anna, Scrima, Marianna, Ottaiano, Alessandro, Savarese, Giovanni, Fico, Antonio, Mesolella, Massimo, Fasano, Morena, Motta, Giovanni, Massimilla, Eva Aurora, Addeo, Raffaele, Ricciardiello, Filippo, Caraglia, Michele, and Misso, Gabriella

Published
2024
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7. Brazil and the transnational human rights movement, 1964-1985

Author

Grimaldi, Anna Isabella, Pereira, Anthony Wynne, and De Carvalho, Vinicius Mariano

Subjects
323.0981
Abstract

The following PhD thesis asks whether Brazilians, as actors of the Global South, contributed to our current human rights regime and the emergence of 'third-generation' rights. It begins by identifying a Brazilian theory of human rights, based on the ontologies of liberation theologians and theories of 'oppression', and argues that through the activity of liberationist clergymen and political exiles in Europe, these ideas came to form part of the global narrative and vision for the future of human rights. By employing a combination of qualitative and quantitative methods to analyse solidarity activism, campaign posters, petitions, and newspaper articles, this research reveals that human rights solidarity activism was a vital space of intellectual exchange and the source of various elements of our contemporary human rights norms. Over time, it was found that European coverage and promotion of human rights in Brazil expanded its focus on the 'political prisoner' and 'violating state' to also defend the struggles of workers, peasants, indigenous peoples, students and other minorities, as well as denouncing poverty, inequality, environmental damage, foreign national interests and the rise of multinational companies.

Published
2019

10. Identification of Tissue miRNA Signatures for Pancreatic Ductal Adenocarcinoma

Author

Caputo, Carlo, primary, Falco, Michela, additional, Grimaldi, Anna, additional, Lombardi, Angela, additional, Miceli, Chiara Carmen, additional, Cocule, Mariateresa, additional, Montella, Marco, additional, Pompella, Luca, additional, Tirino, Giuseppe, additional, Campione, Severo, additional, Tammaro, Chiara, additional, Cossu, Antonio, additional, Fenu Pintori, Grazia, additional, Maioli, Margherita, additional, Coradduzza, Donatella, additional, Savarese, Giovanni, additional, Fico, Antonio, additional, Ottaiano, Alessandro, additional, Conzo, Giovanni, additional, Tathode, Madhura S., additional, Ciardiello, Fortunato, additional, Caraglia, Michele, additional, De Vita, Ferdinando, additional, and Misso, Gabriella, additional

Published
2024
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11. Adequacy of Cytologic Samples by Ultrasound-Guided Percutaneous Transthoracic Fine-Needle Aspiration Cytology of Peripheral Pulmonary Nodules for Morphologic Diagnosis and Molecular Evaluations: Comparison With Computed Tomography-Guided Percutaneous Transthoracic Fine-Needle Aspiration Cytology

Author

Cozzolino, Immacolata, Ronchi, Andrea, Messina, Gaetana, Montella, Marco, Morgillo, Floriana, Vicidomini, Giovanni, Tirino, Virginia, Grimaldi, Anna, Marino, Federica Zito, Santini, Mario, Cappabianca, Salvatore, and Franco, Renato

Subjects
Diagnostic imaging -- Comparative analysis, Ultrasound imaging -- Comparative analysis, CAT scans -- Comparative analysis, Time, Cytochemistry, Tomography, Pneumothorax, Health
Abstract

Context.--Fine-needle aspiration cytology (FNAC) of pulmonary nodules is usually guided by computed tomography (CT), whereas ultrasonography (US) is generally considered not applicable for such purposes. Objective.--To evaluate the clinical applicability and diagnostic utility of US-guided transthoracic FNAC of peripheral pulmonary nodules. Design.--Ultrasonography-guided transthoracic FNAC was obtained from 40 selected patients with peripheral, subpleural, and paravertebral pulmonary nodules. Airdried and Diff-Quik-stained smears were used for rapid on-site evaluation; additional smears were alcohol fixed for Papanicolaou staining. Cell blocks were set up for immunocytochemical and molecular studies; in 2 cases, a flow cytometry evaluation was also performed. The series was compared to 40 CT-guided pulmonary FNAC samples from patients with pleural, peripheral, and paravertebral pulmonary nodules, to evaluate differences in terms of diagnostic rate, time of execution, safety, and cost. Results.--The US-guided FNAC samples had results that were adequate and representative in 95% of cases. No significant differences were observed between the 2 groups in terms of diagnostic rate, number of passes, and cellularity of both smears and cell blocks. The mean time needed for the execution of US-guided FNAC was 13.1 minutes, whereas the mean time for CT-guided FNAC was 23.6 minutes. Thus, US-guided FNAC was significantly more rapid than CT-guided pulmonary FNAC. Because pneumothorax occurred in 1 individual who underwent US-guided FNAC and in 9 who underwent CT-guided FNAC, we might conclude that US-guided FNAC is a significantly safer procedure. Finally, comparing the costs of both procedures, US-guided FNAC is less expensive. Conclusions.--Our experience showed an elevated clinical applicability and diagnostic utility of US-guided transthoracic FNAC for selected pulmonary nodules. (Arch Pathol Lab Med. 2020;144:361-369; doi: 10.5858/arpa.2018-0346-OA), The diagnostic evaluation of peripheral pulmonary lesions is currently based on an integrated approach that includes imaging and direct sampling techniques. In this setting, computed tomography (CT) has taken the [...]

Published
2020
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12. miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma

Author

Misso, Gabriella, Zarone, Mayra Rachele, Lombardi, Angela, Grimaldi, Anna, Cossu, Alessia Maria, Ferri, Carmela, Russo, Margherita, Vuoso, Daniela Cristina, Luce, Amalia, Kawasaki, Hiromichi, Di Martino, Maria Teresa, Virgilio, Antonella, Festa, Agostino, Galeone, Aldo, De Rosa, Giuseppe, Irace, Carlo, Donadelli, Massimo, Necas, Alois, Amler, Evzen, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, and Caraglia, Michele

Published
2024
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14. miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma

Author

Misso, Gabriella, Zarone, Mayra Rachele, Lombardi, Angela, Grimaldi, Anna, Cossu, Alessia Maria, Ferri, Carmela, Russo, Margherita, Vuoso, Daniela Cristina, Luce, Amalia, Kawasaki, Hiromichi, Di Martino, Maria Teresa, Virgilio, Antonella, Festa, Agostino, Galeone, Aldo, De Rosa, Giuseppe, Irace, Carlo, Donadelli, Massimo, Necas, Alois, Amler, Evzen, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, and Caraglia, Michele

Published
2019
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16. Multimodal imaging for a theranostic approach in a murine model of B-cell lymphoma with engineered nanoparticles

Author

Torino, Enza, Auletta, Luigi, Vecchione, Donatella, Orlandella, Francesca Maria, Salvatore, Giuliana, Iaccino, Enrico, Fiorenza, Dario, Grimaldi, Anna Maria, Sandomenico, Annamaria, Albanese, Sandra, Sarnataro, Daniela, Gramanzini, Matteo, Palmieri, Camillo, Scala, Giuseppe, Quinto, Ileana, Netti, Paolo Antonio, Salvatore, Marco, and Greco, Adelaide

Published
2018
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21. Un argine contro la povertà educativa: le linee di indirizzo per il diritto allo studio degli alunni adottati

Author

Ferritti, Monya, Grimaldi, Anna, and Guerrieri, Anna

Subjects
Scuola, Adozione, Adozione Internazionale, Insegnanti, Inclusione, Apprendimento
Abstract

Nel 2014 il Ministero dell'Istruzione ha pubblicato le Linee di indi-rizzo per il diritto allo studio degli alunni adottati, un documento teo-rico-metodologico per favorire l'inclusione scolastica degli alunni adot-tati. Tuttavia, la diffusione è stata frammentata e l'attuazione ineffica-ce. A sei anni dalla redazione questo lavoro ne approfondisce i punti di forza e di debolezza, individua le aree di miglioramento e indica pro-poste per la promozione.

Published
2022
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23. An Encounter with Pan-Africanist Performance through the Dance-Activism of Omar Séne.

Author

Séne, Omar, Gukelberger, Sandrine, and Grimaldi, Anna

Subjects
DANCE, PAN-Africanism, YOUTH movements
Abstract

This text presents a dialogue between Omar Séne, an activist-artist from Senegal, and two researchers, Sandrine Gukelberger from Germany and Anna Grimaldi from the UK. The intention of this particular collaboration is to interrogate the relationship between Pan-African activism in the present and the modes through which they relate to the past. It combines and recontextualises various artefacts, narrative interviews and extracts of Séne's personal archive (including photographs, dance choreographies and on- and offline texts). The aim is twofold: on the one hand, we provide a situated perspective on the pathways of becoming a youth activist in Senegal today, and on the other, we explore one individual's experience of a collective identification with Pan-Africanism. Through this text, we demonstrate how figures of the past are mobilised to drive youth engagement in the present, and how these inherited struggles are perpetuated through bodies. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Reawakening Cold War Social Movements Through Memory Work and Archival Performance.

Author

Grimaldi, Anna and Gukelberger, Sandrine

Subjects
COLD War & politics, SOCIAL movements, ARCHIVES, PAN-Africanism, ETHNOLOGY
Abstract

This article examines the ways in which artefacts of Cold War social movements are reassembled in and through the creation of archives in the present. We ask: how have artefacts of past social movements been re-engaged with memory work through intergenerational transmission and performance? Through the analysis of selected examples, including a) ethnographic work on a Pan-African social movement in Senegal, b) archival research of Cuban Cold War graphic design, and c) a decolonial pedagogical project taking place at a UK university, we illustrate the different – and at times overlapping – dimensions of the 'memory-activism nexus' they engage (Rigney 2018 ; 2020). Through a theoretical framework that draws from social movement theory, memory studies and performance theory in relation to archives, we identify and analyse contemporary engagements with past social movements. We argue that through distinct interpretations, (re)assemblages, and framings of artefacts, memory work through the creation of archives is necessarily an embodied and performative practice. [ABSTRACT FROM AUTHOR]

Published
2024
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28. High risk of unsuccessful treatment outcome in migrant population with tuberculosis: Data from three Italian hospitals

Author

Di Gennaro, Francesco, primary, Cotugno, Sergio, additional, Fasano, Massimo, additional, Ricciardi, Aurelia, additional, Ronga, Luigi, additional, Lattanzio, Rossana, additional, Grimaldi, Anna, additional, Bavaro, Davide Fiore, additional, Ciarallo, Marianna, additional, Garzone, Stefania, additional, De Iaco, Giuseppina, additional, Guido, Giacomo, additional, Fiore, Josè Ramon, additional, Brindicci, Gaetano, additional, Santoro, Carmen Rita, additional, Sica, Salvatore, additional, Iacovazzi, Tiziana Loredana, additional, Santantonio, Teresa Antonia, additional, and Saracino, Annalisa, additional

Published
2023
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44. Abstract PO-052: A pilot study of miRNA expression profile in surgically resected pancreatic ductal adenocarcinoma: Initial report from a bi-institutional cohort

Author

Pompella, Luca, primary, Falco, Michela, additional, Caputo, Carlo, additional, Grimaldi, Anna, additional, Tirino, Giuseppe, additional, Campione, Severo, additional, Sparano, Francesca, additional, Iacovino, Maria Lucia, additional, Miceli, Chiara Carmen, additional, Molino, Carlo, additional, Montella, Marco, additional, Franco, Renato, additional, Galizia, Gennaro, additional, Conzo, Giovanni, additional, Napolitano, Vincenzo, additional, Auricchio, Annamaria, additional, Cardella, Francesca, additional, Ciardiello, Fortunato, additional, Caraglia, Michele, additional, Lombardi, Angela, additional, Misso, Gabriella, additional, and De Vita, Ferdinando, additional

Published
2021
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45. Diagnostic and prognostic significance of extracellular vesicles in prostate cancer drug resistance: A systematic review of the literature

Author

Grimaldi, Anna Maria, Salvatore, Marco, and Cavaliere, Carlo

Abstract

Background: The clinical behavior of prostate cancer is highly heterogeneous, with most patients diagnosed with localized disease that successfully responds to surgery or radiotherapy. Methods: We performed the current systematic review according to PRISMA guidelines and comprehensively explored PubMed, EMBASE and Google Scholar databases to achieve the article search. Results: Thirty-three studies were included and investigated. Among all systematically reviewed EV biomarkers, we found mainly molecules with prognostic significance (61%), molecules with diagnostic relevance (18%), and molecules that serve both purposes (21%). Moreover, among all analyzed molecules isolated from EVs, proteins, mRNAs, and miRNAs emerged to be the most investigated and proposed as potential tools to diagnose or predict resistance/sensitivity to advanced PCa treatments. Discussion: Our analysis provides a snapshot of the current scenario regarding EVs as potential clinical biomarkers in resistant PCa. Nevertheless, despite many efforts, the use of EV biomarkers in PCa is currently at an early stage: none of the selected EV biomarkers goes beyond preclinical studies, and their translatability is yet far from clinical settings.

Published
2023
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46. Prospective Evaluation of Radiotherapy-Induced Immunologic and Genetic Effects in Colorectal Cancer Oligo-Metastatic Patients with Lung-Limited Disease: The PRELUDE-1 Study

Author

Ottaiano, Alessandro, primary, Petito, Angela, additional, Santorsola, Mariachiara, additional, Gigantino, Valerio, additional, Capuozzo, Maurizio, additional, Fontanella, Daniela, additional, Di Franco, Rossella, additional, Borzillo, Valentina, additional, Buonopane, Sergio, additional, Ravo, Vincenzo, additional, Scipilliti, Esmeralda, additional, Totaro, Giuseppe, additional, Serra, Marcello, additional, Ametrano, Gianluca, additional, Penta, Roberta, additional, Tatangelo, Fabiana, additional, Scognamiglio, Giosuè, additional, Di Mauro, Annabella, additional, Di Bonito, Maurizio, additional, Napolitano, Maria, additional, Scala, Stefania, additional, Rea, Giuseppina, additional, Santagata, Sara, additional, Lombardi, Angela, additional, Grimaldi, Anna, additional, Caputo, Carlo, additional, Crispo, Anna, additional, Celentano, Egidio, additional, De Feo, Gianfranco, additional, Circelli, Luisa, additional, Savarese, Giovanni, additional, Ruggiero, Raffaella, additional, Perri, Francesco, additional, Granata, Vincenza, additional, Botti, Gerardo, additional, Caraglia, Michele, additional, Nasti, Guglielmo, additional, and Muto, Paolo, additional

Published
2021
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47. Promuovere l’occupabilità per facilitare la transizione dall’università al lavoro. Uno studio pilota della Federico II

Author

Striano Maura, Capo Marianna, Grimaldi Anna, Striano, Maura, Capo, Marianna, and Grimaldi, Anna

Subjects
occupabilità, orientamento, soft skills
Abstract

Il contributo presenta i risultati di uno studio esplorativo condotto nel 2017-2018 presso l’Ateneo Federiciano, nell’ambito dei servizi specifici offerti dalla Sezione di Promozione dell’Occupabilità del Centro di Ateneo Sinapsi.Nello specifico, lo studio riporta gli esiti di uno screening dei livelli di occupabilità percepita dagli studenti attraverso la somministrazione del questionario Avo Giovani (Grimaldi et al., 2015) messo a punto e validato dall’Inapp. Lafinalità principale dello studio esplorativo è stataquella di mettere a punto un percorso di orientamento specialistico per gli studenti,ancorato al costrutto di Occupabilitàsostenibile. In un’ottica preventiva é importante promuovere l’occupabilità degli studenti giàdurante il percorso di studi, in modo daconsentire loro di gestire attivamente e consapevolmente i processi legati allaprefigurazione e allo sviluppo della carrierap r o f e s s i o n a l e , q u i n d i , i l p a s s a g g i o dall’università al mondo del lavoro.

Published
2020

48. Adequacy of Cytologic Samples by Ultrasound-Guided Percutaneous Transthoracic Fine-Needle Aspiration Cytology of Peripheral Pulmonary Nodules for Morphologic Diagnosis and Molecular Evaluations: Comparison With Computed Tomography-Guided Percutaneous Transthoracic Fine-Needle Aspiration Cytology

Author

Cozzolino, Immacolata, Ronchi, Andrea, Messina, Gaetana, Montella, Marco, Morgillo, Floriana, Vicidomini, Giovanni, Tirino, Virginia, Grimaldi, Anna, Marino, Federica Zito, Santini, Mario, Cappabianca, Salvatore, Franco, Renato, ZITO MARINO, Federica, Cozzolino, Immacolata, Ronchi, Andrea, Messina, Gaetana, Montella, Marco, Morgillo, Floriana, Vicidomini, Giovanni, Tirino, Virginia, Grimaldi, Anna, Marino, Federica Zito, Santini, Mario, Cappabianca, Salvatore, Franco, Renato, and ZITO MARINO, Federica

Subjects
Male, medicine.medical_specialty, Percutaneous, Lung Neoplasms, Cytodiagnosis, Computed tomography, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Fine needle aspiration cytology, Cytology, Medicine, Humans, Prospective Studies, skin and connective tissue diseases, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Lung, Aged, medicine.diagnostic_test, business.industry, Reproducibility of Results, Solitary Pulmonary Nodule, General Medicine, Middle Aged, Prognosis, Ultrasound guided, Aspiration cytology, body regions, Medical Laboratory Technology, 030220 oncology & carcinogenesis, Female, Radiology, Tomography, Morphologic diagnosis, business, Tomography, X-Ray Computed
Abstract

Context.— Fine-needle aspiration cytology (FNAC) of pulmonary nodules is usually guided by computed tomography (CT), whereas ultrasonography (US) is generally considered not applicable for such purposes. Objective.— To evaluate the clinical applicability and diagnostic utility of US-guided transthoracic FNAC of peripheral pulmonary nodules. Design.— Ultrasonography-guided transthoracic FNAC was obtained from 40 selected patients with peripheral, subpleural, and paravertebral pulmonary nodules. Air-dried and Diff-Quik–stained smears were used for rapid on-site evaluation; additional smears were alcohol fixed for Papanicolaou staining. Cell blocks were set up for immunocytochemical and molecular studies; in 2 cases, a flow cytometry evaluation was also performed. The series was compared to 40 CT-guided pulmonary FNAC samples from patients with pleural, peripheral, and paravertebral pulmonary nodules, to evaluate differences in terms of diagnostic rate, time of execution, safety, and cost. Results.— The US-guided FNAC samples had results that were adequate and representative in 95% of cases. No significant differences were observed between the 2 groups in terms of diagnostic rate, number of passes, and cellularity of both smears and cell blocks. The mean time needed for the execution of US-guided FNAC was 13.1 minutes, whereas the mean time for CT-guided FNAC was 23.6 minutes. Thus, US-guided FNAC was significantly more rapid than CT-guided pulmonary FNAC. Because pneumothorax occurred in 1 individual who underwent US-guided FNAC and in 9 who underwent CT-guided FNAC, we might conclude that US-guided FNAC is a significantly safer procedure. Finally, comparing the costs of both procedures, US-guided FNAC is less expensive. Conclusions.— Our experience showed an elevated clinical applicability and diagnostic utility of US-guided transthoracic FNAC for selected pulmonary nodules.

Published
2019

49. Predictive Evaluation on Cytological Sample of Metastatic Melanoma: The Role of BRAF Immunocytochemistry in the Molecular Era

Author

Ronchi, Andrea, primary, Montella, Marco, additional, Zito Marino, Federica, additional, Caraglia, Michele, additional, Grimaldi, Anna, additional, Argenziano, Giuseppe, additional, Moscarella, Elvira, additional, Brancaccio, Gabriella, additional, Troiani, Teresa, additional, Napolitano, Stefania, additional, Franco, Renato, additional, and Cozzolino, Immacolata, additional

Published
2021
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50. Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy?

Author

Ricciardiello, Filippo, primary, Falco, Michela, additional, Tortoriello, Giuseppe, additional, Riccardi, Ferdinando, additional, Pellini, Raul, additional, Iorio, Brigida, additional, Russo, Giuseppe, additional, Longo, Giuseppe, additional, Coppola, Ciro, additional, Takeuchi, Takashi, additional, Grimaldi, Anna, additional, Abate, Marianna, additional, Scrima, Marianna, additional, Cossu, Alessia Maria, additional, Addeo, Raffaele, additional, Ottaiano, Alessandro, additional, Scarpa, Alfonso, additional, Boscaino, Amedeo, additional, Motta, Giovanni, additional, Caraglia, Michele, additional, Bocchetti, Marco, additional, and Misso, Gabriella, additional

Published
2021
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