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34 results on '"Grim, C.E."'

1. Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element

Author

Hoogendijk, C.F, Scholtz, C.L, Pimstone, S.M, Ehrenborg, E, Kastelein, J.J P, Defesche, J.C, Thiart, R, du Plessis, L, de Villiers, J.N.P, Zaahl, M.G, Delport, R, Rubinsztein, D.C, Raffel, L.J, Grim, C.E, Mediene-Benchekor, S, Amouyel, P, Brousseau, T, Steyn, K, Lombard, C.J, Hayden, M.R, and Kotze, M.J

Published
2003
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2. Dilevalol in severe hypertension: a multicenter trial of bolus intravenous dosing

Author

Wallin, J. David, Cook, M. Eileen, Fletcher, E., Holtzman, J.L., Winer, N., Gavras, H., Grim, C.E., Ramanathan, K.B., Vidt, D.G., Johnson, B.F., Hall, D., Stom, M., Poland, M., and Cubbon, J.

Subjects
Antihypertensive drugs -- Evaluation, Dilevalol -- Evaluation, Hypertension -- Drug therapy, Health
Abstract

Dilevalol is a drug prescribed to lower high blood pressure. Dilevalol is a beta-adrenergic antagonist and works by blocking the release of chemicals in the body which raise blood pressure. It is similar to the drug labetalol but is four times more potent. To measure the effectiveness of dilevalol in lowering blood pressure, 101 patients with a diastolic blood pressures of greater than 120 mm Hg were given a supine intravenous bolus, a single shot of dilevalol administered while the patient is lying down. A reduction of from 30 mm Hg to 100 mg Hg was achieved in 62 of the patients. Dilevelol was not as effective in treating high blood pressure in black males. Older patients showed better results than younger patients. Dilevalol did not lower blood pressure as much in patients who had previously taken beta-adrenergic antagonists. Transfer to oral dilevalol drug therapy in combination with diuretics, which are drugs that effectively lower blood pressure by lowering blood volume, was able to stabilize blood pressure at an average level of 160 over 100 mm Hg. Intravenous bolus or oral dilevalol is a safe and effective blood pressure lowering agent in the treatment of severe hypertension.

Published
1989

4. Familial, Dexamethasone-Suppressible, Normokalemic Hyperaldosteronism.

Author

Grim, C.E., Weinberger, M.D., and Weinberger, M.H.

Subjects
*HYPERALDOSTERONISM, *FAMILIAL diseases, *RENIN
Abstract

ABSTRACT. An 8-year-old boy was found to be hypertensive on routine exam (144/88). His brother (age 6) and father (age 31) were also found to have elevated blood pressure. Detailed investigations first revealed a low renin level without hypokalemia. Further study revealed that all three patients had low plasma renin activity and nonsuppresible plasma aldosterone levels after saline infusion.Serum potassium was almost always normal. A trial of dexamethasone therapy normalized blood pressure, and plasma and urinary aldosterone decreased to low levels and renin levels increased. Therapy with spironolactone and prednisone also normalized blood pressure.However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued. Studies in the father suggest that the aldosterone production by his adrenals is hyperresponsive to adrenocorticotropic hormone (ACTH). Renin levels should be determined in all hypertensive children and their hypertensive parents. If renin is low and plasma aldosterone fails to be suppressed by saline infusion, a trial of dexamethasone would seem indicatedbefore other investigations are carried out. Pediatrics 65: 597-604, 1980; hypertension, renin, aldosterone, dexamethasone-suppressible hypertension, genetics. [ABSTRACT FROM AUTHOR]

Published
1980
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6. Circadian rhythm of renin and aldosterone in unilateral renovascular hypertension. Pre- and post-operative studies.

Author

Grim, C.E. and Keitzer, W.F.

Subjects
CIRCADIAN rhythms, RENOVASCULAR hypertension, ALDOSTERONE, RENIN, BLOOD pressure, CREATININE, POSTURE, POTASSIUM, RENAL hypertension, SODIUM, TIME
Abstract

Presents a study which examined the circadian rhythm of plasma renin activity and plasma aldosterone levels in patients with unilateral renovascular hypertension. Laboratory findings of patients involved in the study; Reason behind the unelevated levels of circulating renin despite increased renin production by the ischemic kidney; Method for decreasing peripheral renin levels; Comparison of plasma aldosterone levels in patients with and without unilateral renovascular hypertension.

Published
1974
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8. Hypertension, Adrenal Abnormalities, and Alterations in Plasma Renin Activity.

Author

Gunnells Jr., J. Caulie, McGuffin Jr., W.L., Robinson, R.R., Grim, C.E., Wells, Samuel, Silver, Donald, and Glenn, J.F.

Subjects
INTRACRANIAL hypertension, RENIN, PATIENTS
Abstract

Investigates a serial measurement of peripheral venous plasma renin activity done in a group of patients with benign hypertension. Clinical and laboratory features of hypersensitive patients with subnormal or suppressed plasma renin activity; Plasma renin activity in normotensive and hypertensive subjects; Surgical experience in patients with subnormal plasma renin activity.

Published
1970
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16. Literature Abstracts.

Author

Kotchen, T.A., Piering, A.W., Cowley, A.W., Grim, C.E., Gaudet, D., Hamet, P., Kaldunski, M.L., Kotchen, J.M., Roman, R.J., Thervet, E., Anglicheau, D., Toledano, N., Houllier, A.M., Noel, L.H., Kreis, H., Beaune, P., and Legendre, C.

Subjects
KIDNEY diseases, BLOOD flow, GLOMERULAR filtration rate, METHYLTRANSFERASES, KIDNEY transplantation
Abstract

Presents abstracts of articles concerning kidney diseases, featured in the 2001 issue of the periodical 'Pediatric Nephrology.' Comparison of the responses of renal blood flow and glomerular filtration rate to graded infusions of norepinephrine among whites with hypertension; Results of thiopurine methyltransferase activity monitoring in azathioprine-treated renal allograft recipients.

Published
2001

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