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2. Spin edge states: an exact solution and oscillations of the spin current

Author

Grigoryan, V. L., Abiague, A. Matos, and Badalyan, S. M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study the spin edge states, induced by the combined effect of spin-orbit interaction (SOI) and hard-wall confining potential, in a two-dimensional electron system, exposed to a perpendicular magnetic field. We find an exact solution of the problem and show that the spin resolved edge states are separated in space. The SOI generated rearrangement of the spectrum results in a peaked behavior of the net spin current versus the Fermi energy. The predicted oscillations of the spin current with a period, determined by the SOI renormalized cyclotron energy, can serve as an effective tool for controlling the spin motion in spintronic devices., Comment: 5 pages, Phys. Rev. B 2009

Published
2009
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3. Structural and energetic properties of nickel clusters: $2 \le N \le 150$

Author

Grigoryan, V. G. and Springborg, M.

Subjects
Physics - Atomic and Molecular Clusters, Physics - Chemical Physics
Abstract

The four most stable structures of Ni$_N$ clusters with $N$ from 2 to 150 have been determined using a combination of the embedded-atom method in the version of Daw, Baskes and Foiles, the {\it variable metric/quasi-Newton} method, and our own {\it Aufbau/Abbau} method. A systematic study of energetics, structure, growth, and stability of also larger clusters has been carried through without more or less severe assumptions on the initial geometries in the structure optimization, on the symmetry, or on bond lengths. It is shown that cluster growth is predominantly icosahedral with $islands$ of {\it fcc}, {\it tetrahedral} and {\it decahedral} growth. For the first time in unbiased computations it is found that Ni$_{147}$ is the multilayer (third Mackay) icosahedron. Further, we point to an enhanced ability of {\it fcc} clusters to compete with the icosahedral and decahedral structures in the vicinity of N=79. In addition, it is shown that conversion from the {\it hcp}/anti-Mackay kind of icosahedral growth to the {\it fcc}/Mackay one occurs within a transition layer including several cluster sizes. Moreover, we present and apply different analytical tools in studying structural and energetic properties of such a large class of clusters. These include means for identifying the overall shape, the occurrence of atomic shells, the similarity of the clusters with, e.g., fragments of the {\it fcc} crystal or of a large icosahedral cluster, and a way of analysing whether the $N$-atom cluster can be considered constructed from the $(N-1)$-atom one by adding an extra atom. In addition, we compare in detail with results from chemical-probe experiment. Maybe the most central result is that first for clusters with $N$ above 80 general trends can be identified., Comment: 37 pages, 11 figures

Published
2004
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4. Structure and energetics of Ni clusters with up to 150 atoms

Author

Grigoryan, V. G. and Springborg, M.

Subjects
Physics - Atomic and Molecular Clusters, Physics - Chemical Physics
Abstract

We present a method (the Aufbau/Abbau method) for optimizing the structure of a whole series of clusters without making any assumptions on the structure. Subsequently, the method is combined with the embedded-atom method in determining the structure of the two energetically lowest isomers of Ni_N clusters with N up to 150. Finally, various analytical descriptors are introduced that are used in studying the overall shape of the clusters, their structure and stability, and possible growth and dissociation processes., Comment: 16 pages, 5 figures

Published
2003
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7. The Influence of Structural Inhomogeneities on Intragranular Properties of Y- and Bi-based Superconductors

Author

Grigoryan, V. A.

Subjects
Condensed Matter - Superconductivity
Abstract

The measurements of temperature dependence of AC magnetic susceptibility were used to study the influence of inhomogeneities on intragranular superconducting properties of YBa2Cu3-xMxOy (M=Fe,x=0.005; Al,x=0.01; Cr,x=0.01), Bi1.7Pb0.2Sb0.1Sr2Ca2Cu3Oy and Bi1.5Pb0.3Sb0.2Sr2Ca2Cu3Oy ceramics. It is found that step-like regions are revealed on AC magnetic field dependence curves Tmg(ho) of hysteresis losses peak temperature for superconducting granuls. The steps at temperature scale depend on sample's composition as well as on the type of atoms sabstituted for the copper. They range from 1 to 2 K for Y-based and about 5 k for Bi-basedsamples. Possible interpretation of the obtained results is presented., Comment: 11 pages LeTex, 4 figures,table

Published
1998

8. The Influence of the Bulk Density on the Intergranular Properties of YBa2Cu3-xFexOy (0<x<0.01) Ceramics

Author

Nikogosyan, S. K., Sahakyan, A. A., Yeritsyan, H. N., and Grigoryan, V. A.

Subjects
Condensed Matter
Abstract

The influence of the bulk density of YBa2Cu3-xFexOy (0 < x < 0.01) ceramics on the intergranular superconducting (SC) properties was studied using the temperature dependence of AC magnetic susceptibility measurements. It was found that the simultaneous variation of the sample's density and the iron impurity concentration does not influence effectively the onset temperature of the superconducting state Tc(on). While only increasing of the sample's density shifts the intergranular hysteresis losses peak temperature Tm(J) to the lower values which connects with the decreasing of the Josephson magnetic vortices pinning role. It was established that the shielding capability and Tm(J) display a plateau with X in the 0.003 < X < 0..007 region which is due to the monotonous decrease of the sample's density. It was shown that the shielding capability at the T=78K for the sample with 3.8g/cm3 is two times higher than that for the sample with the density of 5.0g/cm3. The possible interpretations of the observed results are discussed., Comment: 6 pages, LaTex, 4 figures

Published
1998

9. Optical Constants and Functions of Corundum Single Crystals in the Vacuum Ultraviolat Region

Author

Harutunyan, V. V., Hakobyan, T. S., Hovhannesian, A. S., Gevorkyan, V. A., Grigoryan, N. E., Avakyan, A. K., and Grigoryan, V. A.

Subjects
Condensed Matter
Abstract

Optical reflection spectra of corundum single crystals grown by HOC and Verneil methods are investigated before and after irradiated by electrons and neutrons using synchrotron radiation polarization (5-30eV)., Comment: 12 pages, LaTeX file, using RevTeX, 28 JPEG TAR and gzip compressed figures are included

Published
1998

12. Autorotating lander for delivering small scale scientific cargoes from orbital complexes

Author

Pavlyuchenko, V., primary, Denisov, M., additional, Kotlovskikh, P., additional, Mayorova, V., additional, Vasilev, F., additional, Vayuta, M., additional, Naumov, A., additional, Gorbunova, K., additional, Muhamedova, E., additional, Mordovskiy, A., additional, Liu, B., additional, Mikhailov, A., additional, Britov, A., additional, Grigoryan, V., additional, Zhang, Y., additional, Khayrullin, A., additional, and Shvedova, A., additional

Published
2023
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33. THE PATTERN OF PREVALENCE OF CHICKEN EIMERIASIS IN THE REPUBLIC OF ARMENIA.

Author

GRIGORYAN, L. G., HAKOBYAN, A. R., MKRTCHYAN, A. R., SHCHERBAKOV, O. V., ERIBEKYAN, S. V., and GRIGORYAN, V. V.

Subjects
CHICKENS, POULTRY breeding, POULTRY farms, SPECIES distribution, EIMERIA
Abstract

Copyright of Ajastan Kensabanakan Handes is the property of National Academy of Sciences of the Republic of Armenia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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41. Parametric Trapping and Self-Ordering of Solitons

Author

Grigoryan, V. S., Hasegawa, A., Maruta, A., Goldanskii, Vitalii I., editor, Schäfer, Fritz Peter, editor, Toennies, J. Peter, editor, Lotsch, Helmut K. V., editor, Barbara, Paul F., editor, Fujimoto, James G., editor, Knox, Wayne H., editor, and Zinth, Wolfgang, editor

Published
1996
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43. Physicians' guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry

Author

Komajda, M. Schöpe, J. Wagenpfeil, S. Tavazzi, L. Böhm, M. Ponikowski, P. Anker, S.D. Filippatos, G.S. Cowie, M.R. Aleksanyan, A. Atayan, L. Avetisyan, A. Davtyan, N. Drambyan, M. Gevorgyan, K. Grigoryan, M. Hakobyan, Z. Hayrapetyan, H. Kocharyan, L. Kramarevskaya, T. Melqonyan, A. Muradyan, F. Nanyan, R. Ordyan, A. Ordyan, M. Piruzyan, A. Podosyan, G. Safaryan, K. Sargsyan, T. Sarkisyan, A. Sisakyan, H. Ter-Grigoryan, V. Ustyan, T. Alexopoulos, C. Amerena, J. Arstall, M. Ayres, B. Barron, G. Beltrame, J. Bou-Samra, J. Brown, M. Cross, D. Dwyer, N. Eccleston, N. Hare, D. Ho, B. Hopper, I. Jackson, B. Korczyk, D. Lattimore, J.D. Levendel, A. Macfadyen, R. Pandeli, V. Playford, D. Richardson, M. Senior, J.A. Shah, A. Shetty, P. Soward, A. Srivastava, P. Swale, M. Vogl, E. Wai, B. William, M. Worthington, A. Wright, S. Brunner, B. Fuhrmann, W. Horer, L. Maca, T. Nahler, A. Ortner, H. Racz, G. Scheibner, P. Sebald, C. Abdullayev, A. Abdullayev, R. Ahmadov, A. Alakbarov, E. Aliyev, F. Aliyev, F. Bakhshaliyev, A. Bakhshiyev, M. Dadashova, G. Dashdamirov, R. Faradjova, N. Guliyev, A. Guliyev, F. Guliyeva, S. Hajiyev, G. Ibrahimov, F. Imanov, G. Isayeva, A. Isayeva, M. Jabrailova, U. Jafarov, R. Jahangirov, T. Khalilov, A. Khalilov, S. Mehdiyev, S. Najafov, R. Samedova, H. Shahhuseynov, S. Yusifly, R. Yusifov, T. Zahidova, K. Zeynalov, A. Abdullatif, A. Al-Banna, R. Haiky, W. Husain, A. Jamsheer, A. Barbuk, O. Belskaya, M. Borodko, V. Kurlianskaya, A. Mackevich, S. Mankevich, N. Moroz-Vodolazhskaya, N. Ravtovich, O. Saevich, A. Troyanova, T. Chughtai, A. Johar, S. Luqman, N. Nair, T.C.-R. Deyoung, P. Ezekowitz, J. Frenette, M. Howlett, J. Huynh, T. Nguyen, V. Toma, M. Orenstein, T. Rinne, M.R.C. Virani, S. Zieroth, S. Ailiman, M. Cong, H. Ding, W. Dong, W. Dong, Y. Gao, C. Li, L. Li, Z. Liang, Y. Liu, X. Liu, S. Luo, S. Shi, H. Tian, Q. Wang, D. Wang, J. Wei, M. Wu, C. Xu, D. Yang, X. Yang, Z. Zhang, C. Zhang, Q. Zhang, Y. Zhang, R. Zheng, Y. Zhao, L. Zhou, J. Buch, P. Davidsen, F. Eiskjær, H. Bruun, N.E. Kragh-Thomsen, N.E. Franow, H. Køber, L. Korup, E. Madsen, B.K. Mikkelsen, K. Nielsen, K.A. Nørgaard, A. Refsgaard, J. Rickers, H. Kaiser, P. Sykulski, R. Zeuthen, E.L. El Fottoh, A.A. El Badry, M. El Hady, Y.A. El Kady, E. El Khatib, H. Fawzy, M. Hegazy, H. Salama, M.K. Mortada, A. Mostafa, T. Mwafy, A. Ossama, M. Samir, S. Seleem, M. Sobhy, B. Bregadze, G. Chelidze, K. Chumburidze, V. Jalabadze, K. Khabeishvili, G. Kiphiani, Z. Klimiashvili, Z. Kvitsiani, A. Mamatsashvili, M. Melia, I.M.A. Oragvelidze, T. Orjonikidze, S. Paposhvili, K. Petriashvili, S. Phaghava, Z. Shushania, M. Tsetskhladze, E. Tsinamdzgvishvili, B. Abdel-Qader, M. Al-Zoebi, A. Böhm, G. Bosch, R. Brune, S. Bunge, K. Dominick, K. Duda, S. Erdogan, A.E. Faber, G. Fach, C. Fechtrup, C. Frickel, S. Giokoglu, K. Haas, J. Hagenow, A. Haj-Yehia, A. Hansen, C. Hartung, W.M. Hauser, E.R. Hofmeister, A. Hohensee, H. Hüttemann, M. Keim, M. Krämer, A. Langwasser, K. Lodde, B.P. Lorch, G. Lüer, C. Müller, K. Placke, J. Plesch, B. Potolidis, L. Richter, F. Rieker, W.A. Schlichting, J. Stenzel, G. Theuer, J.D. Marcin, A. Warkentin, R. Wegner, M. Wilke, A. Agrafiotis, I. Aleksandridis, I. Farmakis, D. Giannakoulas, G. Karavidas, A. Lamprou, A. Ninios, V. Panagiotopoulos, K. Papadopoulos, K. Siachos, S. Dékány, M. Borbéy, A. Borsányi, T. Forster, T. Gavallér, H. Gyuricza, I. Heltai, K. Herczeg, B. HŐgye, M. Losonczi, I. Merkely, B. Metz, E. Muk, B. Nagy, K. Ökrös, M. Piry, K. Poós, G. Sárszegi, Z. Somogyi, T. Sziliczei-Németh, E. Tátrai, T. Zima, E. Zsigmond, A. Daly, C. Mahon, N. Meany, B. Abbdi, I. Awaysheh, R. Azouka, M. Hamoudeh, S. Nammas, A. Okkeh, O. Aimakova, G. Ismagulova, Z. Issabekova, A. Junusbekova, G.A. Koshumbayeva, K. Madaliyev, K. Mekebekova, D. Mukatova, A. Ospanova, G. Sadvakassova, G. Sunkarbekova, Z. Yegorova, Y. Zhangelova, S. Kim, K.H. Al-Mutairi, M. Gaber, Y. Ghali, I. Ghanem, A. Hafez, H. Haiba, M. Koushy, T. Mahmoud, A. Raafat, G. Sallam, M. Senousi, O. Soliman, M. Massih, T.A. Ali, S.A. Jaoude, S.A. Azzi, N. Badaoui, G. Bayeh, H. Beydoun, A. Chammas, E. Dib, H. Gebran, M. Ghanem, G. Haidar, H. Hamadeh, M. Hamoui, O. Hobeika, R. Jazra, C. Kabbani, S. Kadri, Z. Karanaminassian, R. Kassab, R. Kleit, M. Mansour, H. Mousallem, N. Semaan, C. Simonian, A. Sarkis, A. Succar, S. Zalloum, R. Zind, R. Anusauskiene, J. Grigaliuniene, A. Karaliute, R. Kavoliuniene, A. Kozlovaite, V. Miliuniene, D. Rinkuniene, D. Rudys, A. Stasaityte, D. Aziz, F.A.A. Rahim, A.A.A. Ahmad, R. Ahmadsah, S.H.K.A. Ang, C.C. Ang, S.H. Cham, Y.L. Chee, K.H. Chooi, K.C. Chu, C.M. Fam, T.L. Fong, A. Ismail, O. Ismail, J.R. Kamarulzaman, M.H. Kasim, S.S. Khiew, N.Z. Krishnan, C. Krishinan, S. Lau, G. Lee, L.Y. Liew, H.B. Lim, C.W. Mahendran, K. Dass, R.D.M. Mohamad, R. Arshad, M.K.M. Unit, H.M. Mustapha, Z. Ng, W.K. Ong, T.K. Oon, Y.Y. Ramli, A.W. Ramanathan, G.R.L. Ross, N.T. Said, A. Sarwar, M. Tan, E. Tan, S.K. Voon, C.Y. Yusoff, M.R. Abidin, H.A.Z. Chua, S.K. Yew, K.L. Amin, N.H.M. Kandiah, K. Chong, L.A. Mohamed, M.S. Lim, B.K. Koh, K.T. Low, D.W. Abdelkhirane, C. Allali, Y. Askour, M. Balafrej, K. Bendagha, N. Bendriss, L. Benjelloun, H. Chaib, A. Cherradi, G. Cherti, M. Chtioui, M. El Belghiti, A.R. Fihri, O.F. Habbal, R. El Hattaoui, M. Khatouri, A. Kheyi, J. Kriem, J. Soufiane, N. Soufiani, A. Zaimi, S. Adamczyk-Kot, D. Barg, Z. Bartkowiak, R. Braciszewicz, W. Czajkowska, E. Dudek-Niechciał, M. Grzelakowski, P. Jarosik, Z. Jerzykowska, O. Koprowski, P. Krysiak, W. Łajkowski, Z. Ziemlewska-Krawczyk, E. Lelonek, M. Lewicka, E. Płonka, J. Sadowski, J. StĘpieŃ-Adamczewska, V. Szponar, J. WrzesiŃski, K. Brito, D.A. Araújo, I. Figueiredo, J.P.A. Campelo, M.B. Sardinha, P.M.B. Fernando, P. de Brito Domingues Sanches Peres de Noronha, M.A. Baptista, S.B.C. Cardoso Pinto, J.P. Piçarra, B.M.C. Farto e Abreu, P. da Fonseca, M.C.F.G. Soares, A.I.C.G.O. Resende, J.D.A. Durão, D.L. Nascimento, A.I.F.V. Bernardes, E.L.M.O. Marques, F. Ramos, M.A.N. Sargento, L.J.M. dos Santos, J.P.F. Raimundo, A. da Luz Ventosa, A.M.S. Sarmento, P. Aguiar, C.M.T. Ahmed, E. Al-Suwaidi, J. Al Dabdoob, W. Badr, A. Gomaa, M. Albu, M. Antohi, I. Apavaloaei, C. Ardelean, A. Badea, G. Bicescu, G. Blaj, C. Bogdan, L. Bucatanschi, M. Buzea, A. Calarasu, V. Catinean, S. Christodorescu, R. Cocoi, D. Costache, L. Cretu, D. Crisu, D. Dima-Cozma, C. Dumitrescu, S. Enache, V. Firastrau, V. Frigy, A. Gherghina, A. Girbea, S. Gutu, A. Horovitz, M. Hortopan, G. Istratoaie, O. Jianu, C. Jinga, L. Lighezan, D. Luka, A. Magheru, S. Mercea, D. Miklos, K. Moga, R. Oprea, N. Paraschiv, D.M. Pop, D. Rusu, R. Sirbu, I. Socoteanu, E. Stanciulescu, G. Suteu, A. Tetiu, O. Traistaru, A. Tudoran, M. Turiceanu, M.C. Viinkler, L. Adonina, E. Akinina, S. Alferov, P. Arkhipov, M. Aroutunov, G. Babkin, A. Barbashina, T. Bochkareva, J. Boldueva, S. Bukhonkina, J. Chumakova, S.G. Fayans, I. Furmenko, G. Galyavich, A. Grinstein, Y. Klein, G. Kastanayan, A. Kazachkova, T. Korolev, S. Koshelskaya, O. Kosmacheva, E. Koziolova, N. Kuimov, A. Kushnarenko, N. Lebedev, P. Matushin, G. Mineeva, E. Motylev, I. Nedbaykin, A. Nevzorova, V. Rachkova, S. Rebrov, A. Reznik, I. Saiganov, S. Sayfutdinov, R. Schekotov, V. Serdechnaya, E. Shalaev, S. Shtegman, O. Sitnikova, M. Smolenskaya, O. Sulimov, V. Tarlovskaya, E. Temnikova, E. Timonin, D. Tolstov, S. Uskatch, T. Ustyuzhanin, V. Valeeva, R. Vasyuk, Y. Viktorova, I. Yakushin, S. Zadionchenko, V. Zateischikov, D. Zhirov, I. Bollová, D. Dulková, K. Fazekaš, F. Hermel, I. KŇazeje, M. NedĚĽová, I. Nociar, J. Procházka, L. Pundová, L. Slanina, M. Varga, I. Almenar, L. Beltrán, P. Cobo, M. Delgado, J. Enjuanes, C. Garrido, I. Gómez, M.A. Manito, N. Marzal, D. Murga, N. Ocampo, M. Pérez, J. Sánchez, I. Buakhamsri, A. Leemasawat, K. Kanoksilp, A. Kiatchoosakun, S. Phrommintikul, A. Porapakkham, P. Rodprasert, S. Senthong, V. Wongcharoen, W. Wongwantanee, S. Bahadir, H. Emül, A. Gokce, M. Gurcagan, A. Kaya, O.K. Keser, A. Pinar, P. Taș, M.H. Tosun, H.B. Yazlar, A.S. Yilmaz, S. Yuksel, Y. Bagriy, A. Ivchyna, N. Lyashenko, A. Matviychuk, N. Shchukina, O. Tkach, N. Tseluyko, V. Vasylieva, L. Abdallah, A. Agrawal, A. Basleeb, F. Bazargani, N. Hatou, E. Al Kaddour, A.R. Al Kasser, M. Al Mulla, A. Radaideh, G. Salustri, A. on behalf of the QUALIFY Investigators

Abstract

Background: Physicians' adherence to guideline-recommended therapy is associated with short-term clinical outcomes in heart failure (HF) with reduced ejection fraction (HFrEF). However, its impact on longer-term outcomes is poorly documented. Here, we present results from the 18-month follow-up of the QUALIFY registry. Methods and results: Data at 18 months were available for 6118 ambulatory HFrEF patients from this international prospective observational survey. Adherence was measured as a continuous variable, ranging from 0 to 1, and was assessed for five classes of recommended HF medications and dosages. Most deaths were cardiovascular (CV) (228/394) and HF-related (191/394) and the same was true for unplanned hospitalizations (1175 CV and 861 HF-related hospitalizations, out of a total of 1541). According to univariable analysis, CV and HF deaths were significantly associated with physician adherence to guidelines. In multivariable analysis, HF death was associated with adherence level [subdistribution hazard ratio (SHR) 0.93, 95% confidence interval (CI) 0.87–0.99 per 0.1 unit adherence level increase; P = 0.034] as was composite of HF hospitalization or CV death (SHR 0.97, 95% CI 0.94–0.99 per 0.1 unit adherence level increase; P = 0.043), whereas unplanned all-cause, CV or HF hospitalizations were not (all-cause: SHR 0.99, 95% CI 0.9–1.02; CV: SHR 0.98, 95% CI 0.96–1.01; and HF: SHR 0.99, 95% CI 0.96–1.02 per 0.1 unit change in adherence score; P = 0.52, P = 0.2, and P = 0.4, respectively). Conclusion: These results suggest that physicians' adherence to guideline-recommended HF therapies is associated with improved outcomes in HFrEF. Practical strategies should be established to improve physicians' adherence to guidelines. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology

Published
2019

44. Overview of the AVIRIS 2000 flight season

Author

Green, R. O, Chippendale, B. J, Chovit, C, Chrien, T, Dilanchian, S, Eastwood, M, Faust, J, Grigoryan, V, Holbrook, J, Loaiza, F, Lundeen, S, McCubbin, I, Pavri, B, Raney, J, Sarture, C, and Solis, M

Subjects
Earth Resources And Remote Sensing
Published
2001

49. Physicians' guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry

Author

Komajda, M, Schöpe, J, Wagenpfeil, S, Tavazzi, L, Böhm, M, Ponikowski, P, Anker, SD, Filippatos, GS, Cowie, MR, Aleksanyan, A, Atayan, L, Avetisyan, A, Davtyan, N, Drambyan, M, Gevorgyan, K, Grigoryan, M, Hakobyan, Z, Hayrapetyan, H, Kocharyan, L, Kramarevskaya, T, Melqonyan, A, Muradyan, F, Nanyan, R, Ordyan, A, Ordyan, M, Piruzyan, A, Podosyan, G, Safaryan, K, Sargsyan, T, Sarkisyan, A, Sisakyan, H, Ter-Grigoryan, V, Ustyan, T, Alexopoulos, C, Amerena, John, Arstall, M, Ayres, B, Barron, G, Beltrame, J, Bou-Samra, J, Brown, M, Cross, D, Dwyer, N, Eccleston, N, Hare, D, Ho, B, Hopper, I, Jackson, B, Korczyk, D, Lattimore, JD, Levendel, A, Macfadyen, R, Pandeli, V, Playford, D, Richardson, M, Senior, JA, Shah, A, Shetty, P, Soward, A, Srivastava, P, Swale, M, Vogl, E, Wai, B, William, M, Worthington, A, Wright, S, Brunner, B, Fuhrmann, W, Horer, L, Maca, T, Nahler, A, Ortner, H, Racz, G, Scheibner, P, Sebald, C, Abdullayev, A, Abdullayev, R, Ahmadov, A, Alakbarov, E, Aliyev, F, Bakhshaliyev, A, Bakhshiyev, M, Dadashova, G, Dashdamirov, R, Faradjova, N, Guliyev, A, Guliyev, F, Guliyeva, S, Hajiyev, G, Ibrahimov, F, Imanov, G, Isayeva, A, Isayeva, M, Jabrailova, U, Jafarov, R, Jahangirov, T, Khalilov, A, Khalilov, S, Mehdiyev, S, Komajda, M, Schöpe, J, Wagenpfeil, S, Tavazzi, L, Böhm, M, Ponikowski, P, Anker, SD, Filippatos, GS, Cowie, MR, Aleksanyan, A, Atayan, L, Avetisyan, A, Davtyan, N, Drambyan, M, Gevorgyan, K, Grigoryan, M, Hakobyan, Z, Hayrapetyan, H, Kocharyan, L, Kramarevskaya, T, Melqonyan, A, Muradyan, F, Nanyan, R, Ordyan, A, Ordyan, M, Piruzyan, A, Podosyan, G, Safaryan, K, Sargsyan, T, Sarkisyan, A, Sisakyan, H, Ter-Grigoryan, V, Ustyan, T, Alexopoulos, C, Amerena, John, Arstall, M, Ayres, B, Barron, G, Beltrame, J, Bou-Samra, J, Brown, M, Cross, D, Dwyer, N, Eccleston, N, Hare, D, Ho, B, Hopper, I, Jackson, B, Korczyk, D, Lattimore, JD, Levendel, A, Macfadyen, R, Pandeli, V, Playford, D, Richardson, M, Senior, JA, Shah, A, Shetty, P, Soward, A, Srivastava, P, Swale, M, Vogl, E, Wai, B, William, M, Worthington, A, Wright, S, Brunner, B, Fuhrmann, W, Horer, L, Maca, T, Nahler, A, Ortner, H, Racz, G, Scheibner, P, Sebald, C, Abdullayev, A, Abdullayev, R, Ahmadov, A, Alakbarov, E, Aliyev, F, Bakhshaliyev, A, Bakhshiyev, M, Dadashova, G, Dashdamirov, R, Faradjova, N, Guliyev, A, Guliyev, F, Guliyeva, S, Hajiyev, G, Ibrahimov, F, Imanov, G, Isayeva, A, Isayeva, M, Jabrailova, U, Jafarov, R, Jahangirov, T, Khalilov, A, Khalilov, S, and Mehdiyev, S

Published
2019

50. Effects of MLO crude venom, PLA2 and metalloproteinases enzymes on cardiac cells

Author

Arestakesyan, H., Grigoryan, V., Sarian, Arni, Arestakesyan, H., Grigoryan, V., and Sarian, Arni

Abstract

Macrovipera lebetina obtusa (MLO) snakes presented by several sub-species, which are characterized by a very specific combination of components. Along with common enzymes characteristic of Vipera species, MLO venom contains unique components specific for “obtusa” sub-species, such as disintegrin obtustatin. MLO venom contents metalloproteinases, phospholipase A2, serine proteases, L-alfa amino acid oxidase, few kinds of disintegrins and some other active agents. The cluster of MLO venom components, such as metalloproteinases, obtustatin, C-type lectins and few others are known as cell adhesion inhibition molecules, which are breaking up integrins and cadherins or bind to them. Therefore, the adhesion affecting properties of MLO venom and its action on cell binding in tissue culture is of great interest. We studied effect of venom of MLO living in Armenia on adhesion and metabolic activity of myocardial cells [cardiomyocytes (CM) and cardiac fibroblasts (CF)] and identification of major effector components of MLO venom. Attachment properties of both CM and CF were affected by MLO venom in a dose-dependent manner. Time exposure also has an effect on CMs and CFs attachment to the substrate and to cell-to-cell contact. Longer exposures times result in higher detachment even at the same MLO venom concentrations. Interestingly, both cell types demonstrated increase in metabolic activity upon exposure to non-lethal doses of crude venom. Analysis of individual components of MLO venom resulted improved adhesion of both CM and CF upon inhibition of metalloproteinases by EDTA-Na2 chelating agent or complete block of PLA2 enzyme by bromophenacyl bromide. These results indicate that the aggressive detaching effect of MLO venom is delivered not by an individual component of the venom, but rather is a combinatorial effect of several active ingredients.

Published
2019

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