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3. Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study

Author

Anesi, Adriano, Arca, Marcello, Auricchio, Renata, Averna, Maurizio, Baldera, Davide, Banderali, Giuseppe, Beccuti, Guglielmo, Benso, Andrea, Berteotti, Martina, Bertolini, Stefano, Bianconi, Vanessa, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Bruzzi, Patrizia, Bucci, Marco, Buonuomo, Paola Sabrina, Calabrò, Paolo, Calandra, Sebastiano, Carubbi, Francesca, Cavallaro, Raimondo, Cefalù, Angelo Baldassarre, Cesaro, Arturo, Cipollone, Francesco, Citroni, Nadia, Colombo, Emanuela, Coppola, Chiara, D'Addato, Sergio, Dal Pino, Beatrice, Dalla Nora, Edoardo, De Corrado, Giuseppe, Del Ben, Maria, Di Molfetta, Sergio, Di Taranto, Maria Donata, Fainelli, Giulia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Formisano, Elena, Fortunato, Giuliana, Giaccari, Andrea, Giorgino, Francesco, Grigore, Liliana, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Iughetti, Lorenzo, Lia, Salvatore, Longo, Susanna, Lupi, Alessandro, Mandraffino, Giuseppe, Marcucci, Rossella, Maroni, Lorenzo, Massini, Giulia, Mazza, Elisa, Melchioda, Elena, Meregalli, Giancarla, Minicocci, Ilenia, Moffa, Simona, Mombelli, Giuliana, Muntoni, Sandro, Nascimbeni, Fabio, Negri, Emanuele Alberto, Notargiacomo, Serena, Panfili, Filippo Maria, Parati, Gianfranco, Passaro, Angelina, Pavanello, Chiara, Pecchioli, Valerio, Pecchioli, Lorenzo, Pellegatta, Fabio, Perla, Francesco Massimo, Pipolo, Antonio, Piro, Salvatore, Pirro, Matteo, Pisciotta, Livia, Pujia, Roberta, Putotto, Carolina, Repetti, Elena, Rinaldi, Elisabetta, Romandini, Alessandra, Sani, Elena, Sarnari, Silvia, Sarzani, Riccardo, Sbrana, Francesco, Scicali, Roberto, Scuruchi, Michele, Suppressa, Patrizia, Tarugi, Patrizia, Trenti, Chiara, Vinci, Pierandrea, Werba, José Pablo, Zambon, Sabina, Zambon, Alberto, Zenti, Maria Grazia, Casula, Manuela, Gazzotti, Marta, Capra, Maria Elena, Olmastroni, Elena, Galimberti, Federica, Catapano, Alberico L., and Pederiva, Cristina

Published
2023
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7. Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study

Author

Casula, Manuela, primary, Gazzotti, Marta, additional, Capra, Maria Elena, additional, Olmastroni, Elena, additional, Galimberti, Federica, additional, Catapano, Alberico L., additional, Pederiva, Cristina, additional, Anesi, Adriano, additional, Arca, Marcello, additional, Auricchio, Renata, additional, Averna, Maurizio, additional, Baldera, Davide, additional, Banderali, Giuseppe, additional, Beccuti, Guglielmo, additional, Benso, Andrea, additional, Berteotti, Martina, additional, Bertolini, Stefano, additional, Bianconi, Vanessa, additional, Biasucci, Giacomo, additional, Biolo, Gianni, additional, Bonanni, Luca, additional, Borghi, Claudio, additional, Bossi, Antonio Carlo, additional, Branchi, Adriana, additional, Bruzzi, Patrizia, additional, Bucci, Marco, additional, Buonuomo, Paola Sabrina, additional, Calabrò, Paolo, additional, Calandra, Sebastiano, additional, Carubbi, Francesca, additional, Cavallaro, Raimondo, additional, Cefalù, Angelo Baldassarre, additional, Cesaro, Arturo, additional, Cipollone, Francesco, additional, Citroni, Nadia, additional, Colombo, Emanuela, additional, Coppola, Chiara, additional, D'Addato, Sergio, additional, Dal Pino, Beatrice, additional, Dalla Nora, Edoardo, additional, De Corrado, Giuseppe, additional, Del Ben, Maria, additional, Di Molfetta, Sergio, additional, Di Taranto, Maria Donata, additional, Fainelli, Giulia, additional, Federici, Massimo, additional, Ferri, Claudio, additional, Fiorenza, Anna Maria, additional, Formisano, Elena, additional, Fortunato, Giuliana, additional, Giaccari, Andrea, additional, Giorgino, Francesco, additional, Grigore, Liliana, additional, Guardamagna, Ornella, additional, Iannuzzi, Arcangelo, additional, Iannuzzo, Gabriella, additional, Iughetti, Lorenzo, additional, Lia, Salvatore, additional, Longo, Susanna, additional, Lupi, Alessandro, additional, Mandraffino, Giuseppe, additional, Marcucci, Rossella, additional, Maroni, Lorenzo, additional, Massini, Giulia, additional, Mazza, Elisa, additional, Melchioda, Elena, additional, Meregalli, Giancarla, additional, Minicocci, Ilenia, additional, Moffa, Simona, additional, Mombelli, Giuliana, additional, Muntoni, Sandro, additional, Nascimbeni, Fabio, additional, Negri, Emanuele Alberto, additional, Notargiacomo, Serena, additional, Panfili, Filippo Maria, additional, Parati, Gianfranco, additional, Passaro, Angelina, additional, Pavanello, Chiara, additional, Pecchioli, Valerio, additional, Pecchioli, Lorenzo, additional, Pellegatta, Fabio, additional, Perla, Francesco Massimo, additional, Pipolo, Antonio, additional, Piro, Salvatore, additional, Pirro, Matteo, additional, Pisciotta, Livia, additional, Pujia, Roberta, additional, Putotto, Carolina, additional, Repetti, Elena, additional, Rinaldi, Elisabetta, additional, Romandini, Alessandra, additional, Sani, Elena, additional, Sarnari, Silvia, additional, Sarzani, Riccardo, additional, Sbrana, Francesco, additional, Scicali, Roberto, additional, Scuruchi, Michele, additional, Suppressa, Patrizia, additional, Tarugi, Patrizia, additional, Trenti, Chiara, additional, Vinci, Pierandrea, additional, Werba, José Pablo, additional, Zambon, Sabina, additional, Zambon, Alberto, additional, and Zenti, Maria Grazia, additional

Published
2023
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9. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Author

Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Catapano, Alberico Luigi, Tarugi, Patrizia, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Lupi, Alessandro, Mandraffino, Giuseppe, Marcucci, Rossella, Maroni, Lorenzo, Miccoli, Roberto, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbà, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josè Pablo, Zambon, Sabina, Zenti, Maria Grazia, Minicocci, Ilenia, Noto, Davide, Fortunato, Giuliana, Banderali, Giuseppe, Benso, Andrea, Bigolin, Paola, Bonora, Enzo, Bruzzi, Patrizia, Bucci, Marco, Buonuomo, Paola Sabrina, Capra, Maria Elena, Cardolini, Iris, Cefalù, Baldassarre, Cervelli, Nazzareno, Chiariello, Giuseppe, Cocci, Guido, Colombo, Emanuela, Cremonini, Anna Laura, D'Addato, Sergio, D'Erasmo, Laura, Dal Pino, Beatrice, De Sanctis, Luisa, De Vita, Emanuele, Del Ben, Maria, Di Costanzo, Alessia, Di Taranto, Maria Donata, Fasano, Tommaso, Gentile, Luigi, Gentile, Marco, Ghirardello, Omar, Grigore, Liliana, Lussu, Milena, Meregalli, Giancarla, Moffa, Simona, Montalcini, Tiziana, Morgia, Valeria, Nascimbeni, Fabio, Pasta, Andrea, Pavanello, Chiara, Saitta, Antonino, Scicali, Roberto, Siepi, Donatella, Spagnolli, Walter, Spina, Rossella, Sticchi, Elena, Suppressa, Patrizia, Vigo, Lorenzo, Vinci, Pierandrea, Casula, Manuela, Manzato, Enzo, Olmastroni, Elena, Tragni, Elena, Zampoleri, Veronica, and Pirillo, Angela

Published
2018
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11. Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia

Author

Olmastroni, Elena, primary, Gazzotti, Marta, additional, Averna, Maurizio, additional, Arca, Marcello, additional, Tarugi, Patrizia, additional, Calandra, Sebastiano, additional, Bertolini, Stefano, additional, Catapano, Alberico L., additional, Casula, Manuela, additional, D’Erasmo, Laura, additional, Cefalù, Angelo Baldassare, additional, Bartuli, Andrea, additional, Buonuomo, Paola Sabrina, additional, Benso, Andrea, additional, Beccuti, Guglielmo, additional, Biasucci, Giacomo, additional, Capra, Maria Elena, additional, Biolo, Gianni, additional, Vinci, Pierandrea, additional, Bonanni, Luca, additional, Borghi, Claudio, additional, D’Addato, Sergio, additional, Bossi, Antonio Carlo, additional, Meregalli, Giancarla, additional, Branchi, Adriana, additional, Calabrò, Paolo, additional, Carubbi, Francesca, additional, Nascimbeni, Fabio, additional, Cipollone, Francesco, additional, Bucci, Marco, additional, Citroni, Nadia, additional, Del Ben, Maria, additional, Baratta, Francesco, additional, Federici, Massimo, additional, Montagna, Martina, additional, Ferri, Claudio, additional, Notargiacomo, Serena, additional, Fiorenza, Anna Maria, additional, Colombo, Emanuela, additional, Fortunato, Giuliana, additional, Di Taranto, Maria Donata, additional, Giaccari, Andrea, additional, Moffa, Simona, additional, Giorgino, Francesco, additional, Di Molfetta, Sergio, additional, Guardamagna, Ornella, additional, De Sanctis, Luisa, additional, Iannuzzi, Arcangelo, additional, Cavallaro, Raimondo, additional, Iannuzzo, Gabriella, additional, Gentile, Marco, additional, Iughetti, Lorenzo, additional, Bruzzi, Patrizia, additional, Lia, Salvatore, additional, Lupi, Alessandro, additional, Mandraffino, Giuseppe, additional, Toscano, Arianna, additional, Marcucci, Rossella, additional, Berteotti, Martina, additional, Maroni, Lorenzo, additional, Locatelli, Fabiana, additional, Montalcini, Tiziana, additional, Mombelli, Giuliana, additional, Muntoni, Sandro, additional, Baldera, Davide, additional, Parati, Gianfranco, additional, Passaro, Angelina, additional, Pecchioli, Valerio, additional, Pederiva, Cristina, additional, Banderali, Giuseppe, additional, Pipolo, Antonio, additional, D’Elia, Debora, additional, Pirro, Matteo, additional, Bianconi, Vanessa, additional, Pisciotta, Livia, additional, Formisano, Elena, additional, Purrello, Francesco, additional, Scicali, Roberto, additional, Repetti, Elena, additional, Cantino, Elena, additional, Rinaldi, Elisabetta, additional, Sani, Elena, additional, Sarzani, Riccardo, additional, Spannella, Francesco, additional, Sbrana, Francesco, additional, Dal Pino, Beatrice, additional, Suppressa, Patrizia, additional, Cocco, Veronica, additional, Trenti, Chiara, additional, Negri, Emanuele Alberto, additional, Werba, Josè Pablo, additional, Romandini, Alessandra, additional, Zambon, Sabina, additional, Zambon, Alberto, additional, Zenti, Maria Grazia, additional, Fainelli, Giulia, additional, Pellegatta, Fabio, additional, Grigore, Liliana, additional, Bonomo, Katia, additional, Capatti, Eleonora, additional, Cutolo, Ada, additional, Fimiani, Fabio, additional, Genovesi, Simonetta, additional, Inchiostro, Sandro, additional, Pavanello, Chiara, additional, Pujia, Roberta, additional, Schaffer, Alon, additional, Catapano, Alberico Luigi, additional, Olmastroni, Elena, additional, and Galimberti, Federica, additional

Published
2023
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13. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, and Willeit, Peter

Abstract

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent

Published
2023
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14. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque:Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino, Manzi, Maria V., Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Aşçi, Gülay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W.J., Byrne, Christopher D., Calder, Philip C., Gerstein, Hertzel C., Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki, Olsen, Michael H., Parraga, Grace, Safarova, Maya S., Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D.A., Uthoff, Heiko, van Agtmael, Michiel A., van der Heijden, Amber A., Zozulińska-Ziółkiewicz, Dorota A., Park, Hyun Woong, Lee, Moo Sik, Bae, Jang Ho, Beloqui, Oscar, Landecho, Manuel F., Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergström, Göran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura, Norata, Giuseppe D., Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam, Bots, Michiel L, Sweeting, Michael J., Lorenz, Matthias W., Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino, Manzi, Maria V., Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Aşçi, Gülay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W.J., Byrne, Christopher D., Calder, Philip C., Gerstein, Hertzel C., Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki, Olsen, Michael H., Parraga, Grace, Safarova, Maya S., Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D.A., Uthoff, Heiko, van Agtmael, Michiel A., van der Heijden, Amber A., Zozulińska-Ziółkiewicz, Dorota A., Park, Hyun Woong, Lee, Moo Sik, Bae, Jang Ho, Beloqui, Oscar, Landecho, Manuel F., Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergström, Göran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura, Norata, Giuseppe D., Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam, Bots, Michiel L, Sweeting, Michael J., Lorenz, Matthias W., and Willeit, Peter

Abstract

Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid p

Published
2023

18. Zc3h10 is a novel mitochondrial regulator

Author

Audano, Matteo, Pedretti, Silvia, Cermenati, Gaia, Brioschi, Elisabetta, Diaferia, Giuseppe Riccardo, Ghisletti, Serena, Cuomo, Alessandro, Bonaldi, Tiziana, Salerno, Franco, Mora, Marina, Grigore, Liliana, Garlaschelli, Katia, Baragetti, Andrea, Bonacina, Fabrizia, Catapano, Alberico Luigi, Norata, Giuseppe Danilo, Crestani, Maurizio, Caruso, Donatella, Saez, Enrique, De Fabiani, Emma, and Mitro, Nico

Published
2018
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20. Lipoprotein(a) and family history for cardiovascular disease in paediatric patients: A new frontier in cardiovascular risk stratification. Data from the LIPIGEN paediatric group

Author

Pederiva, Cristina, primary, Capra, Maria Elena, additional, Biasucci, Giacomo, additional, Banderali, Giuseppe, additional, Fabrizi, Enrico, additional, Gazzotti, Marta, additional, Casula, Manuela, additional, Catapano, Alberico L., additional, Arca, Marcello, additional, Averna, Maurizio, additional, Bertolini, Stefano, additional, Calandra, Sebastiano, additional, Catapano, Alberico Luigi, additional, Tarugi, Patrizia, additional, Pellegatta, Fabio, additional, Bartuli, Andrea, additional, Borghi, Claudio, additional, Calabrò, Paolo, additional, Carubbi, Francesca, additional, Cipollone, Francesco, additional, Citroni, Nadia, additional, Del Ben, Maria, additional, Fortunato, Giuliana, additional, Guardamagna, Ornella, additional, Iannuzzi, Arcangelo, additional, Iannuzzo, Gabriella, additional, Iughetti, Lorenzo, additional, Mandraffino, Giuseppe, additional, Maroni, Lorenzo, additional, Mombelli, Giuliana, additional, Muntoni, Sandro, additional, Parati, Gianfranco, additional, Passaro, Angelina, additional, Pederiva, Cristina, additional, Pisciotta, Livia, additional, Pujia, Arturo, additional, Purrello, Francesco, additional, Roscini, Anna Rita, additional, Sarzani, Riccardo, additional, Suppressa, Patrizia, additional, Werba, Josè Pablo, additional, Zambon, Sabina, additional, Zenti, Maria Grazia, additional, Allevi, Massimiliano, additional, Auricchio, Renata, additional, Baldera, Davide, additional, Bruzzi, Patrizia, additional, Bucci, Marco, additional, Buonuomo, Paola Sabrina, additional, Cefalù, Angelo Baldassarre, additional, Covetti, Giuseppe, additional, D'Addato, Sergio, additional, Di Taranto, Maria Donata, additional, Franceschi, Roberto, additional, Fimiani, Fabio, additional, Genovesi, Simonetta, additional, Grigore, Liliana, additional, Lupattelli, Graziana, additional, Madaghiele, Sara, additional, Massini, Giulia, additional, Minicocci, Ilenia, additional, Montalcini, Tiziana, additional, Nascimbeni, Fabio, additional, Pavanello, Chiara, additional, Perla, Francesco Massimo, additional, Peroni, Gaia, additional, Sani, Elena, additional, Scicali, Roberto, additional, Toscano, Arianna, additional, Vigna, Giovanni Battista, additional, Zambon, Alberto, additional, Galimberti, Federica, additional, Olmastroni, Elena, additional, and Zampoleri, Veronica, additional

Published
2022
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21. Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Author

Olmastroni, Elena, primary, Gazzotti, Marta, additional, Arca, Marcello, additional, Averna, Maurizio, additional, Pirillo, Angela, additional, Catapano, Alberico Luigi, additional, Casula, Manuela, additional, Bertolini, Stefano, additional, Calandra, Sebastiano, additional, Tarugi, Patrizia, additional, Pellegatta, Fabio, additional, Bartuli, Andrea, additional, Benso, Andrea, additional, Biasucci, Giacomo, additional, Biolo, Gianni, additional, Bonanni, Luca, additional, Bonomo, Katia, additional, Borghi, Claudio, additional, Bossi, Antonio Carlo, additional, Branchi, Adriana, additional, Calabrò, Paolo, additional, Carubbi, Francesca, additional, Cipollone, Francesco, additional, Citroni, Nadia, additional, Del Ben, Maria, additional, Federici, Massimo, additional, Ferri, Claudio, additional, Fiorenza, Anna Maria, additional, Giaccari, Andrea, additional, Guardamagna, Ornella, additional, Iannuzzi, Arcangelo, additional, Iannuzzo, Gabriella, additional, Iughetti, Lorenzo, additional, Lupattelli, Graziana, additional, Lupi, Alessandro, additional, Mandraffino, Giuseppe, additional, Marcucci, Rossella, additional, Maroni, Lorenzo, additional, Mombelli, Giuliana, additional, Muntoni, Sandro, additional, Pecchioli, Valerio, additional, Pederiva, Cristina, additional, Pipolo, Antonio, additional, Pisciotta, Livia, additional, Pujia, Antonio, additional, Purrello, Francesco, additional, Repetti, Elena, additional, Sabbà, Carlo, additional, Sarzani, Riccardo, additional, Trenti, Chiara, additional, Vigna, Giovanni Battista, additional, Werba, Josè Pablo, additional, Zambon, Sabina, additional, Zenti, Maria Grazia, additional, Di Costanzo, Alessia, additional, Fortunato, Giuliana, additional, Spina, Rossella, additional, Baldera, Davide, additional, Banderali, Giuseppe, additional, Baratta, Francesco, additional, Beccuti, Guglielmo, additional, Bertocco, Sandra, additional, Bruzzi, Patrizia, additional, Bucci, Marco, additional, Buonuomo, Paola Sabrina, additional, Capra, Maria Elena, additional, Cardolini, Iris, additional, Cefalù, Angelo Baldassarre, additional, Cinquegrani, Maria, additional, Colombo, Emanuela, additional, Covetti, Giuseppe, additional, Cremonini, Anna Laura, additional, Cutolo, Ada, additional, D’Addato, Sergio, additional, D’Ambrosio, Vincenzo, additional, De Corrado, Giuseppe, additional, Di Pentima, Chiara, additional, Fimiani, Fabio, additional, Gentile, Marco, additional, Ghirardello, Omar, additional, Giusti, Betti, additional, Grassi, Davide, additional, Grigore, Liliana, additional, Massini, Giulia, additional, Meregalli, Giancarla, additional, Minicocci, Ilenia, additional, Moffa, Simona, additional, Montalcini, Tiziana, additional, Nascimbeni, Fabio, additional, Negri, Emanuele Alberto, additional, Pavanello, Chiara, additional, Prati, Lucia, additional, Roscini, Anna Rita, additional, Sani, Elena, additional, Schaffer, Alon, additional, Scicali, Roberto, additional, Suppressa, Patrizia, additional, Tedeschi, Michele, additional, Vinci, Pierandrea, additional, Manzato, Enzo, additional, Tragni, Elena, additional, and Zampoleri, Veronica, additional

Published
2022
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23. Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration

Author

Willeit, Peter, Thompson, Simon G, Agewall, Stefan, Bergström, Göran, Bickel, Horst, Catapano, Alberico L, Chien, Kuo-Liong, de Groot, Eric, Empana, Jean-Philippe, Etgen, Thorleif, Franco, Oscar H, Iglseder, Bernhard, Johnsen, Stein H, Kavousi, Maryam, Lind, Lars, Liu, Jing, Mathiesen, Ellisiv B, Norata, Giuseppe D, Olsen, Michael H, Papagianni, Aikaterini, Poppert, Holger, Price, Jackie F, Sacco, Ralph L, Yanez, David N, Zhao, Dong, Schminke, Ulf, Bülbül, Alpaslan, Polak, Joseph F, Sitzer, Matthias, Hofman, Albert, Grigore, Liliana, Dörr, Marcus, Su, Ta-Chen, Ducimetière, Pierre, Xie, Wuxiang, Ronkainen, Kimmo, Kiechl, Stefan, Rundek, Tatjana, Robertson, Christine, Fagerberg, Björn, Bokemark, Lena, Steinmetz, Helmuth, Ikram, Arfan M, Völzke, Henry, Lin, Hung-Ju, Plichart, Matthieu, Tuomainen, Tomi-Pekka, Desvarieux, Moise, McLachlan, Stela, Schmidt, Caroline, Kauhanen, Jussi, Willeit, Johann, Lorenz, Matthias W, and Sander, Dirk

Published
2016
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24. Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia

Author

Averna, Maurizio, Bilato, Claudio, Sesti, Giorgio, on behalf of the Italian Clinical Network on Bempedoic Acid, Andreini, Daniele, Bonora, Enzo, Campo, Gianluca, Catalini, Roberto, Ciccone, Matteo Marco, De Rosa, Salvatore, Di Mario, Carlo, Ferri, Claudio, Ferri, Nicola, Grigore, Liliana, Lanzilli, Antonio, Mandraffino, Giuseppe, Montalcini, Tiziana, Nardi, Federico, Pirro, Matteo, Pontremoli, Roberto, Prati, Francesco, Purrello, Francesco, Russo, Vincenzo, Sampietro, Tiziana, Sarzani, Riccardo, Scherillo, Marino, Scicali, Roberto, Suppressa, Patrizia, Temporelli, Pierluigi, Terrosu, Pierfrancesco, Tespili, Maurizio, Trevisan, Roberto, Averna M., Bilato C., and Sesti G.

Subjects
ATP citrate lyase, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Hyperlipidemias, Pharmacology, Lipid-lowering therapy, Lipid-lowering treatment, Medicine, LDL-cholesterol, Humans, Dicarboxylic Acids, Hypolipidemic Agents, Ldl cholesterol, Nutrition and Dietetics, Lipid management, business.industry, Novel LDL-C treatment, Fatty Acids, Cholesterol, LDL, Bempedoic acid, bempedoic acid, lipid-lowering treatment, novel LDL-C treatment, Lipid lowering, Cardiology and Cardiovascular Medicine, business, Clinical evaluation
Abstract

Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid management experts gathered to discuss several open questions on BA characteristics and BArelated practical clinical issues. The panel permitted collection of its opinions in a ten Q&A format. Aim: The aim of this viewpoint is to discuss and answer several open questions on BA characteristics and BA-related practical clinical issues. Data synthesis: The data includes main phase III studies, subanalysis and meta-analysis on BA. Conclusions: The panel permitted collection of its opinions in a ten Q&A format.

Published
2021

25. Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration

Author

Lorenz, Matthias W., Price, Jackie F., Robertson, Christine, Bots, Michiel L., Polak, Joseph F., Poppert, Holger, Kavousi, Maryam, Dörr, Marcus, Stensland, Eva, Ducimetiere, Pierre, Ronkainen, Kimmo, Kiechl, Stefan, Sitzer, Matthias, Rundek, Tatjana, Lind, Lars, Liu, Jing, Bergström, Göran, Grigore, Liliana, Bokemark, Lena, Friera, Alfonsa, Yanez, David, Bickel, Horst, Ikram, M. Arfan, Völzke, Henry, Johnsen, Stein Harald, Empana, Jean Philippe, Tuomainen, Tomi-Pekka, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Xie, Wuxiang, Schmidt, Caroline, Norata, Giuseppe D., Suarez, Carmen, Sander, Dirk, Hofman, Albert, Schminke, Ulf, Mathiesen, Ellisiv, Plichart, Matthieu, Kauhanen, Jussi, Willeit, Johann, Sacco, Ralph L., McLachlan, Stela, Zhao, Dong, Fagerberg, Björn, Catapano, Alberico L., Gabriel, Rafael, Franco, Oscar H., Bülbül, Alpaslan, Scheckenbach, Frank, Pflug, Anja, Gao, Lu, and Thompson, Simon G.

Published
2015
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26. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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29. Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis

Author

Baragetti, Andrea, primary, Severgnini, Marco, additional, Olmastroni, Elena, additional, Dioguardi, Carola Conca, additional, Mattavelli, Elisa, additional, Angius, Andrea, additional, Rotta, Luca, additional, Cibella, Javier, additional, Caredda, Giada, additional, Consolandi, Clarissa, additional, Grigore, Liliana, additional, Pellegatta, Fabio, additional, Giavarini, Flavio, additional, Caruso, Donatella, additional, Norata, Giuseppe Danilo, additional, Catapano, Alberico Luigi, additional, and Peano, Clelia, additional

Published
2021
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30. Prevalence and relationship between metabolic syndrome and risk of cardiovascular disease: Evidence from two population-based studies

Author

Alieva, Asiiat S., primary, Olmastroni, Elena, additional, Reutova, Olga V., additional, Rotar, Oxana P., additional, Konradi, Alexandra O., additional, Shlyakhto, Evgeny V., additional, Baragetti, Andrea, additional, Grigore, Liliana, additional, Pellegatta, Fabio, additional, Casula, Manuela, additional, Tragni, Elena, additional, and Catapano, Alberico L., additional

Published
2020
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32. Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors

Author

Baragetti, Andrea, primary, Bonacina, Fabrizia, additional, Da Dalt, Lorenzo, additional, Moregola, Annalisa, additional, Zampoleri, Veronica, additional, Pellegatta, Fabio, additional, Grigore, Liliana, additional, Pirillo, Angela, additional, Spina, Rossella, additional, Cefalù, Angelo Baldassarre, additional, Averna, Maurizio, additional, Norata, Giuseppe D, additional, and Catapano, Alberico L, additional

Published
2020
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37. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

Author

PROG-IMT Study Group, Bahls, Martin, Lorenz, Matthias W., Dörr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., Gilst, Wiek van, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Hecht Olsen, Michael, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, Groot, Eric de, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos I., Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergström, Göran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Völzke, Henry, Thompson, Simon G., PROG-IMT Study Group, Bahls, Martin, Lorenz, Matthias W., Dörr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., Gilst, Wiek van, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Hecht Olsen, Michael, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, Groot, Eric de, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos I., Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergström, Göran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Völzke, Henry, and Thompson, Simon G.

Abstract

Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in

Published
2019

39. Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN)

Author

Averna, Maurizio, Cefalã¹, Angelo B., Casula, Manuela, Noto, Davide, Arca, Marcello, Bertolini, Stefano, Calandra, Sebastiano, Catapano, Alberico L., Tarugi, Patrizia, Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, SabbÃ&nbsp, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josà Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Fortunato, Giuliana, Grigore, Liliana, Del Ben, Maria, Maranghi, Marianna, Barbagallo, Carlo M., Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iris, Cervelli, Nazzareno, Emanuela, Colombo, Vinsin, A. Sun, Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Chiodo, Lorenzo, Garlaschelli, Katia, Manzato, Enzo, Tragni, Elena, Averna, M., Cefalu', A., Casula, M., Noto, D., Arca, M., Bertolini, S., Calandra, S., Catapano, A., Tarugi, P., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A., Branchi, A., Carubbi, F., Cipollone, F., Citroni, N., Federici, M., Ferri, C., Fiorenza, A., Giaccari, A., Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Mandraffino, G., Marcucci, R., Mombelli, G., Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabbã , C., Sampietro, T., Sarzani, R., Tagliabue, M., Trenti, C., Vigna, G., Werba, J., Zambon, S., Zenti, M., Montali, A., Fortunato, G., Grigore, L., Del Ben, M., Maranghi, M., Cefalã¹, A., Barbagallo, C., Buonuomo, P., Capra, M., Vinci, P., D'Addato, S., Galbiati, S., Nascimbeni, F., Bucci, M., Spagnoli, W., Cardolini, I., Cervelli, N., Emanuela, C., Vinsin, A., Laviola, L., Bello, F., Chiariello, G., Predieri, B., Siepi, D., Saitta, A., Giusti, B., Pavanello, C., Lussu, M., Prati, L., Banderali, G., Balleari, G., Montalcini, T., Scicali, R., Gentile, L., Gentile, M., Suppressa, P., Sbrana, F., Cocci, G., Benso, A., Negri, E., Ghirardello, O., Lorenzo, V., Zambon, A., Enzo, B., Minicocci, I., Spina, R., Orlando, C., Di Taranto, M., Chiodo, L., Garlaschelli, K., Manzato, E., Tragni, E., Averna, Maurizio, Cefalã¹, Angelo B., Casula, Manuela, Noto, Davide, Arca, Marcello, Bertolini, Stefano, Calandra, Sebastiano, Catapano, Alberico L., Tarugi, Patrizia, Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbã , Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josã Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Fortunato, Giuliana, Grigore, Liliana, DEL BELLO, Francesca, Maranghi, Marianna, Barbagallo, Carlo M., Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iri, Cervelli, Nazzareno, Emanuela, Colombo, Vinsin, A. Sun, Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Chiodo, Lorenzo, Garlaschelli, Katia, Manzato, Enzo, Tragni, Elena, Cefalù, Angelo B., Sabbà, Carlo, Werba, Josè Pablo, Del Ben, Maria, and Colombo, Emanuela

Subjects
0301 basic medicine, Candidate gene, Genetic testing, Settore MED/09 - Medicina Interna, Databases, Factual, DNA Mutational Analysis, Disease, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, 0302 clinical medicine, Dyslipidemias, National network, Internal Medicine, Cardiology and Cardiovascular Medicine, Risk Factors, Prospective Studies, Program Development, Prospective cohort study, medicine.diagnostic_test, General Medicine, Prognosis, Cholesterol, Phenotype, Italy, Genetic Markers, medicine.medical_specialty, MEDLINE, Hyperlipoproteinemia Type II, 03 medical and health sciences, Databases, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Factual, Retrospective Studies, business.industry, Settore MED/13 - ENDOCRINOLOGIA, Retrospective cohort study, medicine.disease, Atherosclerosis, Mutation, 030104 developmental biology, Endocrinology, Dyslipidemia, Genetic marker, business
Abstract

Background and aims: Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels of circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease. We set up an Italian nationwide network aimed at facilitating the clinical and genetic diagnosis of genetic dyslipidemias named LIPIGEN (LIpid TransPort Disorders Italian GEnetic Network). Methods: Observational, multicenter, retrospective and prospective study involving about 40 Italian clinical centers. Genetic testing of the appropriate candidate genes at one of six molecular diagnostic laboratories serving as nationwide DNA diagnostic centers. Results and conclusions: From 2012 to October 2016, available biochemical and clinical information of 3480 subjects with familial hypercholesterolemia identified according to the Dutch Lipid Clinic Network (DLCN) score were included in the database and genetic analysis was performed in 97.8% of subjects, with a mutation detection rate of 92.0% in patients with DLCN score >= 6. The establishment of the LIPIGEN network will have important effects on clinical management and it will improve the overall identification and treatment of primary dyslipidemias in Italy. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.

Published
2017

40. Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study

Author

Pirillo, Angela, Garlaschelli, Katia, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Catapano, Alberico L., Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, SabbÃ&nbsp, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josà Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Noto, Davide, Fortunato, Giuliana, Grigore, Liliana, Del Ben, Maria, Maranghi, Marianna, Cefalã¹, A. Baldassarre, Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iris, Cervelli, Nazzareno, Emanuela, Colombo, Sun, Vinsin A., Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Casula, Manuela, Chiodo, Lorenzo, Manzato, Enzo, Tragni, Elena, Pirillo, Angela, Garlaschelli, Katia, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Catapano, Alberico L., Catapano, Alberico Luigi, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Mandraffino, Giuseppe, Marcucci, Rossella, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbã , Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josã Pablo, Zambon, Sabina, Zenti, Maria Grazia, Montali, Anna, Noto, Davide, Fortunato, Giuliana, Grigore, Liliana, DEL BELLO, Francesca, Maranghi, Marianna, Cefalã¹, A. Baldassarre, Buonuomo, Paola Sabrina, Capra, Maria Elena, Vinci, Pierandrea, D'Addato, Sergio, Galbiati, Stella, Nascimbeni, Fabio, Bucci, Marco, Spagnoli, Walter, Cardolini, Iri, Cervelli, Nazzareno, Emanuela, Colombo, Sun, Vinsin A., Laviola, Luigi, Bello, Francesca, Chiariello, Giuseppe, Predieri, Barbara, Siepi, Donatella, Saitta, Antonino, Giusti, Betti, Pavanello, Chiara, Lussu, Milena, Prati, Lucia, Banderali, Giuseppe, Balleari, Giulia, Montalcini, Tiziana, Scicali, Roberto, Gentile, Luigi, Gentile, Marco, Suppressa, Patrizia, Sbrana, Francesco, Cocci, Guido, Benso, Andrea, Negri, Emanuele Alberto, Ghirardello, Omar, Lorenzo, Vigo, Zambon, Alberto, Enzo, Bonora, Minicocci, Ilenia, Spina, Rossella, Orlando, Camilla, Di Taranto, Maria Donata, Casula, Manuela, Chiodo, Lorenzo, Manzato, Enzo, Tragni, Elena, Sabbà, Carlo, Werba, Josè Pablo, Del Ben, Maria, Cefalù, A. Baldassarre, DI BELLO, Francesca, Pirillo, A., Garlaschelli, K., Arca, M., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Catapano, A., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A., Branchi, A., Carubbi, F., Cipollone, F., Citroni, N., Federici, M., Ferri, C., Fiorenza, A., Giaccari, A., Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Mandraffino, G., Marcucci, R., Mombelli, G., Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabbã , C., Sampietro, T., Sarzani, R., Tagliabue, M., Trenti, C., Vigna, G., Werba, J., Zambon, S., Zenti, M., Montali, A., Noto, D., Fortunato, G., Grigore, L., Del Ben, M., Maranghi, M., Cefalu', A., Buonuomo, P., Capra, M., Vinci, P., D'Addato, S., Galbiati, S., Nascimbeni, F., Bucci, M., Spagnoli, W., Cardolini, I., Cervelli, N., Emanuela, C., Sun, V., Laviola, L., Bello, F., Chiariello, G., Predieri, B., Siepi, D., Saitta, A., Giusti, B., Pavanello, C., Lussu, M., Prati, L., Banderali, G., Balleari, G., Montalcini, T., Scicali, R., Gentile, L., Gentile, M., Suppressa, P., Sbrana, F., Cocci, G., Benso, A., Negri, E., Ghirardello, O., Lorenzo, V., Zambon, A., Enzo, B., Minicocci, I., Spina, R., Orlando, C., Di Taranto, M., Casula, M., Chiodo, L., Manzato, E., Tragni, E., and Colombo, Emanuela

Subjects
0301 basic medicine, Apolipoprotein E, Candidate gene, Settore MED/09 - Medicina Interna, Databases, Factual, Apolipoprotein B, DNA Mutational Analysis, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Compound heterozygosity, PCSK9, 0302 clinical medicine, Risk Factors, Receptors, Genetics, Homozygote, Autosomal dominant trait, Pathogenic variants, General Medicine, Prognosis, APOB, LDLR, Cholesterol, Phenotype, Italy, Autosomal Recessive Hypercholesterolemia, Apolipoprotein B-100, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, Preliminary Data, Genetic Markers, Familial hypercholesterolemiaLDLRPCSK9APOBPathogenic variants, Heterozygote, Biology, Pathogenic variant, LDL, Hyperlipoproteinemia Type II, 03 medical and health sciences, Databases, medicine, Internal Medicine, Humans, Genetic Predisposition to Disease, Factual, Settore MED/13 - ENDOCRINOLOGIA, medicine.disease, Atherosclerosis, 030104 developmental biology, Receptors, LDL, Mutation, biology.protein
Abstract

Background Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated plasma levels of LDL-cholesterol that confers an increased risk of premature atherosclerotic cardiovascular disease. Early identification and treatment of FH patients can improve prognosis and reduce the burden of cardiovascular mortality. Aim of this study was to perform the mutational analysis of FH patients identified through a collaboration of 20 Lipid Clinics in Italy (LIPIGEN Study). Methods We recruited 1592 individuals with a clinical diagnosis of definite or probable FH according to the Dutch Lipid Clinic Network criteria. We performed a parallel sequencing of the major candidate genes for monogenic hypercholesterolemia (LDLR, APOB, PCSK9, APOE, LDLRAP1, STAP1). Results A total of 213 variants were detected in 1076 subjects. About 90% of them had a pathogenic or likely pathogenic variants. More than 94% of patients carried pathogenic variants in LDLR gene, 27 of which were novel. Pathogenic variants in APOB and PCSK9 were exceedingly rare. We found 4 true homozygotes and 5 putative compound heterozygotes for pathogenic variants in LDLR gene, as well as 5 double heterozygotes for LDLR/APOB pathogenic variants. Two patients were homozygous for pathogenic variants in LDLRAP1 gene resulting in autosomal recessive hypercholesterolemia. One patient was found to be heterozygous for the ApoE variant p.(Leu167del), known to confer an FH phenotype. Conclusions This study shows the molecular characteristics of the FH patients identified in Italy over the last two years. Full phenotypic characterization of these patients and cascade screening of family members is now in progress.

Published
2017

41. Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Author

Lorenz, Matthias W., Bickel, Horst, Bots, Michiel L., Breteler, Monique M.B., Catapano, Alberico L., Desvarieux, Moise, Hedblad, Bo, Iglseder, Bernhard, Johnsen, Stein Harald, Juraska, Michal, Kiechl, Stefan, Mathiesen, Ellisiv B., Norata, Giuseppe D., Grigore, Liliana, Polak, Joseph, Poppert, Holger, Rosvall, Maria, Rundek, Tatjana, Sacco, Ralph L., Sander, Dirk, Sitzer, Matthias, Steinmetz, Helmuth, Stensland, Eva, Willeit, Johann, Witteman, Jacqueline, Yanez, David, and Thompson, Simon G.

Published
2010

42. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

Author

Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D.A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Arfan Ikram, M., Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Beloqui, Oscar, Engström, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta Chen, Schmidt, Caroline, Tuomainen, Tomi Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Bots, Michiel L., and on behalf of the PROG-IMT study group

Subjects
Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all)
Abstract

Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95–1.02) in group A, 0.98 (0.93–1.04) in group B, and 0.95 (0.89–1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07–1.23) in group A, 1.13 (1.05–1.22) in group B, and 1.12 (1.05–1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018

45. Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes

Author

Purvis, Gareth S. D., primary, Collino, Massimo, additional, Loiola, Rodrigo A., additional, Baragetti, Andrea, additional, Chiazza, Fausto, additional, Brovelli, Martina, additional, Sheikh, Madeeha H., additional, Collotta, Debora, additional, Cento, Alessia, additional, Mastrocola, Raffaella, additional, Aragno, Manuela, additional, Cutrin, Juan C., additional, Reutelingsperger, Chris, additional, Grigore, Liliana, additional, Catapano, Alberico L., additional, Yaqoob, Magdi M., additional, Norata, Giuseppe Danilo, additional, Solito, Egle, additional, and Thiemermann, Christoph, additional

Published
2019
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46. Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity

Author

Bonacina, Fabrizia, primary, Moregola, Annalisa, additional, Porte, Rémi, additional, Baragetti, Andrea, additional, Bonavita, Eduardo, additional, Salatin, Alice, additional, Grigore, Liliana, additional, Pellegatta, Fabio, additional, Molgora, Martina, additional, Sironi, Marina, additional, Barbati, Elisa, additional, Mantovani, Alberto, additional, Bottazzi, Barbara, additional, Catapano, Alberico Luigi, additional, Garlanda, Cecilia, additional, and Norata, Giuseppe Danilo, additional

Published
2019
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47. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D.A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Arfan Ikram, M., Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Beloqui, Oscar, Engström, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta Chen, Schmidt, Caroline, Tuomainen, Tomi Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Bots, Michiel L., on behalf of the PROG-IMT study group, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D.A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Arfan Ikram, M., Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Beloqui, Oscar, Engström, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta Chen, Schmidt, Caroline, Tuomainen, Tomi Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Bots, Michiel L., and on behalf of the PROG-IMT study group

Published
2018

48. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – results from the PROG-IMT collaboration

Author

Pirro, Matteo, PROG-IMT study group, Lorenz, Matthias, Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Beloqui, Oscar, Engström, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergström, Göran, Kauhanen, Jussi, Tremoli, Elena, Dörr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, De Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, De Groot, Eric, Bots, Michiel L., Yanez, David N., Thompson, Simon G., Pirro, Matteo, PROG-IMT study group, Lorenz, Matthias, Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Beloqui, Oscar, Engström, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergström, Göran, Kauhanen, Jussi, Tremoli, Elena, Dörr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, De Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, De Groot, Eric, Bots, Michiel L., Yanez, David N., and Thompson, Simon G.

Abstract

Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95–1.02) in group A, 0.98 (0.93–1.04) in group B, and 0.95 (0.89–1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07–1.23) in group A, 1.13 (1.05–1.22) in group B, and 1.12 (1.05–1.20) in group C. Conclusions: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018

49. Automatic identification of variables in epidemiological datasets using logic regression

Author

Lorenz, Matthias W., Abdi, Negin Ashtiani, Scheckenbach, Frank, Pflug, Anja, Bülbül, Alpaslan, Catapano, Alberico L., Agewall, Stefan, Ezhov, Marat, Bots, Michiel L., Kiechl, Stefan, Orth, Andreas, Norata, Giuseppe D., Empana, Jean Philippe, Lin, Hung Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Kato, Akihiko, Dimitriadis, Chrystosomos, Przewlocki, Tadeusz, Okazaki, Shuhei, Stehouwer, C. D.A., Lazarevic, Tatjana, Willeit, Peter, Yanez, David N., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Bevc, Sebastjan, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Engström, Gunnar, Tripepi, Giovanni, Beloqui, Oscar, Lee, Moo Sik, Friera, Alfonsa, Xie, Wuxiang, Grigore, Liliana, Plichart, Matthieu, Su, Ta Chen, Robertson, Christine, Schmidt, Caroline, Tuomainen, Tomi Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Jovanovic, Aleksandar, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Hojs, Radovan, Uthoff, Heiko, Hedblad, Bo, Park, Hyun Woong, Suarez, Carmen, Zhao, Dong, Catapano, Alberico, Ducimetiere, Pierre, Chien, Kuo Liong, Price, Jackie F., Bergström, Göran, Kauhanen, Jussi, Tremoli, Elena, Dörr, Marcus, Berenson, Gerald, Papagianni, Aikaterini, Kablak-Ziembicka, Anna, Kitagawa, Kazuo, Dekker, Jaqueline M., Stolic, Radojica, Polak, Joseph F., Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Ekart, Robert, Frauchiger, Beat, Castelnuovo, Samuela, Rosvall, Maria, Zoccali, Carmine, Landecho, Manuel F., Bae, Jang Ho, Gabriel, Rafael, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, APH - Health Behaviors & Chronic Diseases, AII - Infectious diseases, APH - Aging & Later Life, and Epidemiology

Subjects
Carotid Artery Diseases, Matching (statistics), Databases, Factual, Epidemiologic Factors, Computer science, Epidemiology, Sample (statistics), Health Informatics, Logistic regression, computer.software_genre, lcsh:Computer applications to medicine. Medical informatics, Data management, Carotid Intima-Media Thickness, Set (abstract data type), 03 medical and health sciences, 0302 clinical medicine, Meta-Analysis as Topic, Backup, Predictive Value of Tests, Statistics, Journal Article, Data Mining, Humans, 030212 general & internal medicine, Medical Informatics Applications, Health Policy, Prognosis, Logic regression, Computer Science Applications, Identification (information), Variable (computer science), Meta-analysis, Logistic Models, 030220 oncology & carcinogenesis, Data quality, lcsh:R858-859.7, Data mining, computer, Algorithms, Research Article
Abstract

Background For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this can be a time-consuming and error-prone task. Automated or semi-automated identification of variables can help to reduce the workload and improve the data quality. For semi-automation high sensitivity in the recognition of matching variables is particularly important, because it allows creating software which for a target variable presents a choice of source variables, from which a user can choose the matching one, with only low risk of having missed a correct source variable. Methods For each variable in a set of target variables, a number of simple rules were manually created. With logic regression, an optimal Boolean combination of these rules was searched for every target variable, using a random subset of a large database of epidemiological and clinical cohort data (construction subset). In a second subset of this database (validation subset), this optimal combination rules were validated. Results In the construction sample, 41 target variables were allocated on average with a positive predictive value (PPV) of 34%, and a negative predictive value (NPV) of 95%. In the validation sample, PPV was 33%, whereas NPV remained at 94%. In the construction sample, PPV was 50% or less in 63% of all variables, in the validation sample in 71% of all variables. Conclusions We demonstrated that the application of logic regression in a complex data management task in large epidemiological IPD meta-analyses is feasible. However, the performance of the algorithm is poor, which may require backup strategies.

Published
2017
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50. Prevalence Of Statin-Associated Muscle Symptoms In Italy : The Prosisa Study

Author

Grigore, Liliana

Abstract

Statin-associated muscle symptoms (SAMS) are one of the main reasons for statin non-adherence and/or discontinuation.The PROSISA is an observational, retrospective and multicenter study aimed at assessing the prevalence of statin intolerance, due to muscolar symptoms, in dyslipidemic patients on statins followed by Italian lipid clinics. Anamnestic data, biochemical values, and potential occurence of muscular symptoms were collected. Adjusted logistic regression was fitted to estimate odds ratio (OR) and 95% confidence intervals for the association between SAMS onset and several factors.In the first six months of activity, the PROSISA database accounted for 6429 patients (mean age 66.7u00b112 years; 53.9% males) on statins. During statin therapy, 787 patients (12.2%) reported muscular symptoms (63,9% within the first year of treatment): myalgia (74.2%) and cramps (25.8%), mainly. Among them, 375 patients underwent dechallenge, with disappearance of muscular symptoms in 87.2% of cases, while overall 503 patients underwent rechallenge (237 with change of statin/dose reduction without interruption of therapy) mainly with low-intensity statins, with reappearance of muscular symptoms (myalgia 76.2%) in only 151 patients. Risk of SAMS onset was significantly higher for patients with diabetes (OR 1.58 [1.26-1.98]), using high potency statins (OR 1.32 [1.09-1.59]) and with an interacting drugs therapy (OR 1.65 [1.14-2.39]).This analysis offers a real life outlook of SAMS. The percentage of patients in whom intolerance has been confirmed by dechallenge/rechallenge is between 26-30%, emphasizing the need to deepen the assessment beyond the simple occurrence of muscle symptoms for definitive diagnosis of SAMS and if needed treatment re-evaluation.

Published
2017

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