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3. Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets

Author

Dooley, Nicholas L., Chabikwa, Tinashe G., Pava, Zuleima, Loughland, Jessica R., Hamelink, Julianne, Berry, Kiana, Andrew, Dean, Soon, Megan S. F., SheelaNair, Arya, Piera, Kim A., William, Timothy, Barber, Bridget E., Grigg, Matthew J., Engwerda, Christian R., Lopez, J. Alejandro, Anstey, Nicholas M., and Boyle, Michelle J.

Published
2023
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6. Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Koh, Gavin CKW, Mekuria, Asrat Hailu, Mueller, Ivo, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Price, David J, Sattabongkot, Jetsumon, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Commons, Robert J, Rajasekhar, Megha, Edler, Peta, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Chu, Cindy S, Cui, Liwang, Daher, André, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Lidia, Kartini, Llanos-Cuentas, Alejandro, Longley, Rhea J, Pereira, Dhelio B, Pasaribu, Ayodhia P, Pukrittayakamee, Sasithon, Rijal, Komal R, Sutanto, Inge, Taylor, Walter R J, Thanh, Pham V, Thriemer, Kamala, Vieira, José Luiz F, Watson, James A, Zuluaga-Idarraga, Lina M, White, Nicholas J, Guerin, Philippe J, Simpson, Julie A, and Price, Ric N

Published
2024
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7. Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Khan, Wasif Ali, Koh, Gavin CKW, Mekuria, Asrat Hailu, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Pasaribu, Ayodhia Pitaloka, Price, David J, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Rajasekhar, Megha, Simpson, Julie A, Ley, Benedikt, Edler, Peta, Chu, Cindy S, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Bancone, Germana, Barber, Bridget E, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Llanos-Cuentas, Alejandro, Pukrittayakamee, Sasithon, Rijal, Komal R, Saravu, Kavitha, Sutanto, Inge, Taylor, Walter R J, Thriemer, Kamala, Watson, James A, Guerin, Philippe J, White, Nicholas J, Price, Ric N, and Commons, Robert J

Published
2024
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8. Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.

Author

Westaway, Jacob, primary, Diez Benavente, Ernest, additional, Auburn, Sarah, additional, Kucharski, Michal, additional, Aranciaga, Nicolas, additional, Nayak, Sourav, additional, William, Timothy, additional, Rajahram, Giri S, additional, Piera, Kim A, additional, Braima, Kamil, additional, Tan, Angelica F, additional, Alaza, Danshy, additional, Barber, Bridget E, additional, Drakeley, Chris, additional, Amato, Roberto, additional, Sutanto, Edwin, additional, Trimarsanto, Hidayat, additional, Anstey, Nicholas M, additional, Bozdech, Zbynek, additional, Field, Matthew, additional, and Grigg, Matthew J, additional

Published
2024
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9. Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

Author

Longley, Rhea J., Grigg, Matthew J., Schoffer, Kael, Obadia, Thomas, Hyslop, Stephanie, Piera, Kim A., Nekkab, Narimane, Mazhari, Ramin, Takashima, Eizo, Tsuboi, Takafumi, Harbers, Matthias, Tetteh, Kevin, Drakeley, Chris, Chitnis, Chetan E., Healer, Julie, Tham, Wai-Hong, Sattabongkot, Jetsumon, White, Michael T., Cooper, Daniel J., Rajahram, Giri S., Barber, Bridget E., William, Timothy, Anstey, Nicholas M., and Mueller, Ivo

Published
2022
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11. A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria

Author

Trimarsanto, Hidayat, Amato, Roberto, Pearson, Richard D., Sutanto, Edwin, Noviyanti, Rintis, Trianty, Leily, Marfurt, Jutta, Pava, Zuleima, Echeverry, Diego F., Lopera-Mesa, Tatiana M., Montenegro, Lidia M., Tobón-Castaño, Alberto, Grigg, Matthew J., Barber, Bridget, William, Timothy, Anstey, Nicholas M., Getachew, Sisay, Petros, Beyene, Aseffa, Abraham, Assefa, Ashenafi, Rahim, Awab G., Chau, Nguyen H., Hien, Tran T., Alam, Mohammad S., Khan, Wasif A., Ley, Benedikt, Thriemer, Kamala, Wangchuck, Sonam, Hamedi, Yaghoob, Adam, Ishag, Liu, Yaobao, Gao, Qi, Sriprawat, Kanlaya, Ferreira, Marcelo U., Laman, Moses, Barry, Alyssa, Mueller, Ivo, Lacerda, Marcus V. G., Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Mohammed, Rezika, Yilma, Daniel, Pereira, Dhelio B., Espino, Fe E. J., Chu, Cindy S., Vélez, Iván D., Namaik-larp, Chayadol, Villegas, Maria F., Green, Justin A., Koh, Gavin, Rayner, Julian C., Drury, Eleanor, Gonçalves, Sónia, Simpson, Victoria, Miotto, Olivo, Miles, Alistair, White, Nicholas J., Nosten, Francois, Kwiatkowski, Dominic P., Price, Ric N., and Auburn, Sarah

Published
2022
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13. Neutrophil activation, acute lung injury and disease severity in Plasmodium knowlesi malaria.

Author

Tan, Angelica F., Sakam, Sitti Saimah binti, Piera, Kim, Rajahram, Giri S., William, Timothy, Barber, Bridget E., Anstey, Nicholas M., Grigg, Matthew J., and Kho, Steven

Subjects
LEUCOCYTES, LEUCOCYTE elastase, HOSPITAL admission & discharge, MALARIA, NEUTROPHILS
Abstract

The risk of severe malaria from the zoonotic parasite Plasmodium knowlesi approximates that from P. falciparum. In severe falciparum malaria, neutrophil activation contributes to inflammatory pathogenesis, including acute lung injury. The role of neutrophil activation in the pathogenesis of severe knowlesi malaria has not been examined. We evaluated 213 patients with P. knowlesi mono-infection (138 non-severe, 75 severe) and 49 Plasmodium-negative controls from Malaysia. Markers of neutrophil activation (soluble neutrophil elastase [NE], citrullinated histone [CitH3] and circulating neutrophil extracellular traps [NETs]) were quantified in peripheral blood by microscopy and immunoassays. Findings were correlated with malaria severity, ALI clinical criteria, biomarkers of parasite biomass, haemolysis, and endothelial activation. Neutrophil activation increased with disease severity, with median levels higher in severe than non-severe malaria and controls for NE (380[IQR:210–930]ng/mL, 236[139–448]ng/mL, 218[134–307]ng/mL, respectively) and CitH3 (8.72[IQR:3.0–23.1]ng/mL, 4.29[1.46–9.49]ng/mL, 1.53[0.6–2.59]ng/mL, respectively)[all p<0.01]. NETs were higher in severe malaria compared to controls (126/μL[IQR:49–323] vs 51[20–75]/μL, p<0.001). In non-severe malaria, neutrophil activation fell significantly upon discharge from hospital (p<0.03). In severe disease, NETs, NE, and CitH3 were correlated with parasitaemia, cell-free haemoglobin and angiopoietin-2 (all Pearson's r>0.24, p<0.05). Plasma NE and angiopoietin-2 were higher in knowlesi patients with ALI than those without (p<0.008); neutrophilia was associated with an increased risk of ALI (aOR 3.27, p<0.01). In conclusion, neutrophil activation is increased in ALI and in proportion to disease severity in knowlesi malaria, is associated with endothelial activation, and may contribute to disease pathogenesis. Trials of adjunctive therapies to regulate neutrophil activation are warranted in severe knowlesi malaria. Author summary: The most common malaria in Malaysia is caused by animal-to-human transmission of Plasmodium knowlesi from its natural monkey hosts to humans via mosquito bites. As the human immune system responds to such infection, white blood cells such as neutrophils are recruited, activated and release products with pathogen-killing activity. There is increasing evidence that neutrophil products cause damage to the host and contribute to severe disease. While this has been studied in human-only malaria, the role of neutrophils in zoonotic P. knowlesi malaria is poorly understood. In this study, we examined three markers of neutrophil activation (neutrophil elastase, citrullinated histone H3 and neutrophil extracellular traps) in hospital patients with severe and non-severe knowlesi malaria from Sabah, East Malaysia. Compared to healthy controls, neutrophil activation was increased in patients with knowlesi malaria in proportion to disease severity. The increase in neutrophil activation was also linked to different types of severe malaria manifestations, especially acute lung injury. These findings have implications for development of new strategies to prevent host organ damage for better treatment of severe knowlesi malaria. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Updating estimates of Plasmodium knowlesi malaria risk in response to changing land use patterns across Southeast Asia

Author

Tobin, Ruarai J., primary, Harrison, Lucinda E., additional, Tully, Meg K., additional, Lubis, Inke N. D., additional, Noviyanti, Rintis, additional, Anstey, Nicholas M., additional, Rajahram, Giri S., additional, Grigg, Matthew J., additional, Flegg, Jennifer A., additional, Price, David J., additional, and Shearer, Freya M., additional

Published
2024
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18. Longitudinal changes in iron homeostasis in human experimental and clinical malaria

Author

Woolley, Stephen D, primary, Grigg, Matthew J, additional, Marquart, Louise, additional, Gower, Jeremy, additional, Piera, Kim, additional, Sheela Nair, Arya, additional, Amante, Fiona M, additional, Rajahram, Giri S, additional, William, Timothy, additional, Frazer, David M, additional, Chalon, Stephan, additional, McCarthy, James S, additional, Anstey, Nicholas M, additional, and Barber, Bridget E, additional

Published
2023
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21. Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia

Author

Grigg, Matthew J., William, Timothy, Clemens, Emily G., Patel, Kaajal, Chandna, Arjun, Wilkes, Christopher S., Barber, Bridget E., Anstey, Nicholas M., Dumler, J. Stephen, Yeo, Tsin W., and Reller, Megan E.

Subjects
EDTA, Immunoglobulin G, Health
Abstract

Rickettsioses and related infections, including scrub typhus, caused by Orientia tsutsugamushi; spotted fever group rickettsioses (SFGR), often called tick typhus; and typhus group rickettsioses (TGR), also called murine typhus, are [...]

Published
2020
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24. Plasmodium knowlesi detection methods for human infections—Diagnosis and surveillance

Author

Grigg, Matthew J., primary, Lubis, Inke N., additional, Tetteh, Kevin K.A., additional, Barber, Bridget E., additional, William, Timothy, additional, Rajahram, Giri S., additional, Tan, Angelica F., additional, Sutherland, Colin J., additional, Noviyanti, Rintis, additional, Drakeley, Chris J., additional, Britton, Sumudu, additional, and Anstey, Nicholas M., additional

Published
2021
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30. The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis

Author

Commons, Robert J, Simpson, Julie A, Thriemer, Kamala, Humphreys, Georgina S, Abreha, Tesfay, Alemu, Sisay G, Añez, Arletta, Anstey, Nicholas M, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Borghini-Fuhrer, Isabelle, Chu, Cindy S, D'Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J, Erhart, Annette, Gomes, Margarete S M, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Heidari, Aliehsan, Hwang, Jimee, Kager, Piet A, Ketema, Tsige, Khan, Wasif A, Lacerda, Marcus V G, Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M, Nosten, Francois, Pereira, Dhelio B, Phan, Giao T, Phyo, Aung P, Rowland, Mark, Saravu, Kavitha, Sibley, Carol H, Siqueira, André M, Stepniewska, Kasia, Sutanto, Inge, Taylor, Walter R J, Thwaites, Guy, Tran, Binh Q, Tran, Hien T, Valecha, Neena, Vieira, José Luiz F, Wangchuk, Sonam, William, Timothy, Woodrow, Charles J, Zuluaga-Idarraga, Lina, Guerin, Philippe J, White, Nicholas J, and Price, Ric N

Published
2018
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36. Effect of Primaquine Dose on the Risk of Recurrence in Patients with Uncomplicated&nbsp; Plasmodium Vivax: A Systematic Review and Individual Patient Data Meta-Analysis

Author

Commons, Robert J., primary, Rajasekhar, Megha, additional, Edler, Peta, additional, Abreha, Tesfay, additional, Awab, Ghulam Rahim, additional, Baird, J. Kevin, additional, Barber, Bridget, additional, Chu, Cindy S., additional, Cui, Liwang, additional, Daher, Andre, additional, Gonzalez-Ceron, Lilia, additional, Grigg, Matthew J., additional, Hwang, Jimee, additional, Karunajeewa, Harin, additional, Lacerda, Marcus, additional, Ladeia-Andrade, Simone, additional, Lidia, Kartini, additional, Llanos-Cuentas, Alejandro, additional, Longley, Rhea J., additional, Pereira, Dhelio B., additional, Pasaribu, Ayodhia Pitaloka, additional, Pukrittayakamee, Sasithon, additional, Rijal, Komal Raj, additional, Sutanto, Inge, additional, Taylor, Walter, additional, Thanh, Pham Vinh, additional, Thriemer, Kamala, additional, Vieira, Jose Luis F., additional, Watson, James A., additional, Zuluaga-Idarraga, Lina M., additional, White, Nicholas J., additional, Guerin, Philippe, additional, Simpson, Julie A., additional, Price, Ric N., additional, and Study Group, WorldWide Antimalarial Resistance Network (WWARN), additional

Published
2023
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40. Additional file 1 of Quantification of parasite clearance in Plasmodium knowlesi infections

Author

T. Thurai Rathnam, Jeyamalar, Grigg, Matthew J., Dini, Saber, William, Timothy, Sakam, Sitti Saimah, Cooper, Daniel J., Rajahram, Giri S., Barber, Bridget E., Anstey, Nicholas M., Haghiri, Ali, Rajasekhar, Megha, and Simpson, Julie A.

Abstract

Additional file1: Figure S1. Example of the traceplot before and after thinning for the population mean parasite clearance rate, $$\gamma$$ γ . Figure S2. Example of the traceplot before and after thinning for the probability of lag and tail phases, $${\pi }^{\ell}$$ π ℓ and $${\pi }^{\tau }$$ π τ . Table S1. Summary statistics for parasite clearance rates (/hour) using WWARN PCE and Bayesian hierarchical modelling methods. Table S2. Estimated parasite clearance rates by antimalarial treatment administered using WWARN PCE and Bayesian hierarchical modelling.

Published
2023
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42. The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Author

Commons, Robert J., Simpson, Julie A., Thriemer, Kamala, Chu, Cindy S., Douglas, Nicholas M., Abreha, Tesfay, Alemu, Sisay G., Añez, Arletta, Anstey, Nicholas M., Aseffa, Abraham, Assefa, Ashenafi, Awab, Ghulam R., Baird, J. Kevin, Barber, Bridget E., Borghini-Fuhrer, Isabelle, D’Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J., Erhart, Annette, Gomes, Margarete S. M., Grigg, Matthew J., Hwang, Jimee, Kager, Piet A., Ketema, Tsige, Khan, Wasif A., Lacerda, Marcus V. G., Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M., Pereira, Dhelio B., Phan, Giao T., Phyo, Aung P., Rowland, Mark, Saravu, Kavitha, Sibley, Carol H., Siqueira, André M., Stepniewska, Kasia, Taylor, Walter R. J., Thwaites, Guy, Tran, Binh Q., Hien, Tran T., Vieira, José Luiz F., Wangchuk, Sonam, Watson, James, William, Timothy, Woodrow, Charles J., Nosten, Francois, Guerin, Philippe J., White, Nicholas J., and Price, Ric N.

Published
2019
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43. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

Author

Adam, Ishag, Alam, Mohammad Shafiul, Alemu, Sisay, Amaratunga, Chanaki, Amato, Roberto, Andrianaranjaka, Voahangy, Anstey, Nicholas M, Aseffa, Abraham, Ashley, Elizabeth, Assefa, Ashenafi, Auburn, Sarah, Barber, Bridget E, Barry, Alyssa, Batista Pereira, Dhelio, Cao, Jun, Chau, Nguyen Hoang, Chotivanich, Kesinee, Chu, Cindy, Dondorp, Arjen M, Drury, Eleanor, Echeverry, Diego F, Erko, Berhanu, Espino, Fe, Fairhurst, Rick, Faiz, Abdul, Fernanda Villegas, María, Gao, Qi, Golassa, Lemu, Goncalves, Sonia, Grigg, Matthew J, Hamedi, Yaghoob, Hien, Tran Tinh, Htut, Ye, Johnson, Kimberly J, Karunaweera, Nadira, Khan, Wasif, Krudsood, Srivicha, Kwiatkowski, Dominic P, Lacerda, Marcus, Ley, Benedikt, Lim, Pharath, Liu, Yaobao, Llanos-Cuentas, Alejandro, Lon, Chanthap, Lopera-Mesa, Tatiana, Marfurt, Jutta, Michon, Pascal, Miotto, Olivo, Mohammed, Rezika, Mueller, Ivo, Namaik-Larp, Chayadol, Newton, Paul N, Nguyen, Thuy-Nhien, Nosten, Francois, Noviyanti, Rintis, Pava, Zuleima, Pearson, Richard D, Petros, Beyene, Phyo, Aung P, Price, Ric N, Pukrittayakamee, Sasithon, Rahim, Awab Ghulam, Randrianarivelojosia, Milijaona, Rayner, Julian C, Rumaseb, Angela, Siegel, Sasha V, Simpson, Victoria J, Thriemer, Kamala, Tobon-Castano, Alberto, Trimarsanto, Hidayat, Urbano Ferreira, Marcelo, Vélez, Ivan D, Wangchuk, Sonam, Wellems, Thomas E, White, Nicholas J, William, Timothy, Yasnot, Maria F, Yilma, Daniel, Alam, Mohammad Shafiul [0000-0001-8330-5499], Ashley, Elizabeth [0000-0002-7620-4822], Barber, Bridget E [0000-0003-1066-7960], Batista Pereira, Dhelio [0000-0002-7761-5498], Chu, Cindy [0000-0001-9465-8214], Dondorp, Arjen M [0000-0001-5190-2395], Echeverry, Diego F [0000-0003-0301-4478], Espino, Fe [0000-0003-1690-1711], Faiz, Abdul [0000-0002-3460-7535], Golassa, Lemu [0000-0002-1216-8711], Grigg, Matthew J [0000-0001-9914-8352], Karunaweera, Nadira [0000-0003-3985-1817], Kwiatkowski, Dominic P [0000-0002-5023-0176], Ley, Benedikt [0000-0002-5734-0845], Miotto, Olivo [0000-0001-8060-6771], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Pearson, Richard D [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Urbano Ferreira, Marcelo [0000-0002-5293-9090], Wellems, Thomas E [0000-0003-3899-8454], Yasnot, Maria F [0000-0001-8081-4212], Yilma, Daniel [0000-0001-6058-2696], and Apollo - University of Cambridge Repository

Subjects
parasitic diseases, Genomics, Genomic Epidemiology, Plasmodium vivax, Malaria, Data Resource
Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination.

Published
2022

44. The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis

Author

Mousa, Andria, Al-Taiar, Abdullah, Anstey, Nicholas M., Badaut, Cyril, Barber, Bridget E., Bassat, Quique, Challenger, Joseph D., Cunnington, Aubrey J., Datta, Dibyadyuti, Drakeley, Chris, Ghani, Azra C., Gordeuk, Victor R., Grigg, Matthew J., Hugo, Pierre, John, Chandy C., Mayor, Alfredo, Migot-Nabias, Florence, Opoka, Robert O., Pasvol, Geoffrey, Rees, Claire, Reyburn, Hugh, Riley, Eleanor M., Shah, Binal N., Sitoe, Antonio, Sutherland, Colin J., Thuma, Philip E., Unger, Stefan A., Viwami, Firmine, Walther, Michael, Whitty, Christopher J. M., William, Timothy, and Okell, Lucy C.

Subjects
Patient care -- Quality management -- Influence -- Patient outcomes, Malaria -- Development and progression -- Drug therapy -- Patient outcomes, Biological sciences
Abstract

Background Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as 'test-and-treat' policies administered by community health workers (CHWs). We conducted a pooled individual-participant meta-analysis to estimate the association between treatment delay and presenting with SM. Methods and findings A search using Ovid MEDLINE and Embase was initially conducted to identify studies on severe Plasmodium falciparum malaria that included information on treatment delay, such as fever duration (inception to 22nd September 2017). Studies identified included 5 case-control and 8 other observational clinical studies of SM and UM cases. Risk of bias was assessed using the Newcastle-Ottawa scale, and all studies were ranked as 'Good', scoring [greater than or equal to]7/10. Individual-patient data (IPD) were pooled from 13 studies of 3,989 (94.1% aged 3 to [less than or equal to]4 days versus [less than or equal to]24 hours: cerebral malaria [CM] = 2.42 [1.24-4.72], p = 0.01; respiratory distress syndrome [RDS] = 4.09 [1.70-9.82], p = 0.002). In addition to unmeasured confounding, which is commonly present in observational studies, a key limitation is that many severe cases and deaths occur outside healthcare facilities in endemic countries, where the effect of delayed or no treatment is difficult to quantify. Conclusions Our results quantify the relationship between rapid access to treatment and reduced risk of severe disease, which was particularly strong for SMA. There was some evidence to suggest that progression to other severe phenotypes may also be prevented by prompt treatment, though the association was not as strong, which may be explained by potential selection bias, sample size issues, or a difference in underlying pathology. These findings may help assess the impact of interventions that improve access to treatment., Author(s): Andria Mousa 1,*, Abdullah Al-Taiar 2, Nicholas M. Anstey 3,4, Cyril Badaut 5,6, Bridget E. Barber 3,7, Quique Bassat 8,9,10,11,12, Joseph D. Challenger 1, Aubrey J. Cunnington 13, Dibyadyuti [...]

Published
2020
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46. Quantification of parasite clearance in Plasmodium knowlesi infections

Author

Rathnam, Jeyamalar T Thurai, primary, Grigg, Matthew J, additional, Dini, Saber, additional, William, Timothy, additional, Sakam, Sitti Saimah binti, additional, Cooper, Daniel J, additional, Rajahram, Giri S, additional, Barber, Bridget E, additional, Anstey, Nicholas M, additional, Haghiri, Ali, additional, Rajasekhar, Megha, additional, and Simpson, Julie A, additional

Published
2022
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47. No association between thePlasmodium vivax crt-oMS334 or In9pvcrtpolymorphisms and chloroquine failure in a clinical cohort from Malaysia

Author

Rumaseb, Angela, primary, Moraes Barros, Roberto R., additional, Sá, Juliana M., additional, Juliano, Jonathan J., additional, William, Timothy, additional, Braima, Kamil A., additional, Barber, Bridget E., additional, Anstey, Nicholas M, additional, Price, Ric N., additional, Grigg, Matthew J., additional, Auburn, Sarah, additional, and Marfurt, Jutta, additional

Published
2022
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48. Malaria drives unique regulatory responses across multiple immune cell subsets

Author

Dooley, Nicholas L., primary, Chabikwa, Tinashe G., additional, Pava, Zuleima, additional, Loughland, Jessica R., additional, Hamelink, Julianne, additional, Berry, Kiana, additional, Andrew, Dean, additional, Soon, Megan S.F., additional, SheelaNair, Arya, additional, Piera, Kim A., additional, William, Timothy, additional, Barber, Bridget E., additional, Grigg, Matthew J., additional, Engwerda, Christian R., additional, López, J. Alejandro, additional, Anstey, Nicholas M., additional, and Boyle, Michelle J., additional

Published
2022
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49. Diagnostic accuracy and limit of detection of ten malaria parasite lactate dehydrogenase-based rapid tests for Plasmodium knowlesi and P. falciparum

Author

Tan, Angelica F., primary, Sakam, Sitti Saimah binti, additional, Rajahram, Giri S., additional, William, Timothy, additional, Abd Rachman Isnadi, Mohammad Faruq, additional, Daim, Sylvia, additional, Barber, Bridget E., additional, Kho, Steven, additional, Sutherland, Colin J., additional, Anstey, Nicholas M., additional, Yerlikaya, Seda, additional, van Schalkwyk, Donelly A., additional, and Grigg, Matthew J., additional

Published
2022
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50. Plasmodium knowlesi Malaria During Pregnancy

Author

Barber, Bridget E., Bird, Elspeth, Wilkes, Christopher S., William, Timothy, Grigg, Matthew J., Paramaswaran, Uma, Menon, Jayaram, Jelip, Jenarun, Yeo, Tsin W., and Anstey, Nicholas M.

Published
2015

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