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3. Children’s Health in London and Luton (CHILL) cohort: a 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school

Author

Xiao, Christina, Scales, James, Chavda, Jasmine, Dove, Rosamund E., Tsocheva, Ivelina, Wood, Helen E., Kalsi, Harpal, Sartori, Luke, Colligan, Grainne, Moon, Jessica, Lie, Esther, Petrovic, Kristian, Day, Bill, Howett, Cheryll, Keighley, Amanda, Mihaylova, Borislava, Toffolutti, Veronica, Grigg, Jonathan, Randhawa, Gurch, Sheikh, Aziz, Fletcher, Monica, Mudway, Ian, Beevers, Sean, Gauderman, W. James, Griffiths, Christopher J., van Sluijs, Esther, and Panter, Jenna

Published
2024
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5. Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries

Author

Machado, Pedro M, Schäfer, Martin, Mahil, Satveer K, Liew, Jean, Gossec, Laure, Dand, Nick, Pfeil, Alexander, Strangfeld, Anja, Regierer, Anne Constanze, Fautrel, Bruno, Alonso, Carla Gimena, Saad, Carla GS, Griffiths, Christopher EM, Lomater, Claudia, Miceli-Richard, Corinne, Wendling, Daniel, Rodriguez, Deshire Alpizar, Wiek, Dieter, Mateus, Elsa F, Sirotich, Emily, Soriano, Enrique R, Ribeiro, Francinne Machado, Omura, Felipe, Martins, Frederico Rajão, Santos, Helena, Dau, Jonathan, Barker, Jonathan N, Hausmann, Jonathan, Hyrich, Kimme L, Gensler, Lianne, Silva, Ligia, Jacobsohn, Lindsay, Carmona, Loreto, Pinheiro, Marcelo M, Zelaya, Marcos David, de los Ángeles Severina, María, Yates, Mark, Dubreuil, Maureen, Gore-Massy, Monique, Romeo, Nicoletta, Haroon, Nigil, Sufka, Paul, Grainger, Rebecca, Hasseli, Rebecca, Lawson-Tovey, Saskia, Bhana, Suleman, Pham, Thao, Olofsson, Tor, Bautista-Molano, Wilson, Wallace, Zachary S, Yiu, Zenas ZN, Yazdany, Jinoos, Robinson, Philip C, and Smith, Catherine H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Clinical Research, Arthritis, Autoimmune Disease, Psoriasis, Good Health and Well Being, Adult, Humans, Male, Arthritis, Psoriatic, Rheumatology, COVID-19, Axial Spondyloarthritis, Physicians, Glucocorticoids, Interleukin-12, Registries, Covid-19, Psoriatic, Autoimmunity, Spondylitis, Ankylosing, Spondylitis, Ankylosing, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectivesTo investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).MethodsDemographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression.ResultsOf 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19.ConclusionOlder age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.

Published
2023

6. Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

Author

Zhou, Wei, Kanai, Masahiro, Wu, Kuan-Han H, Rasheed, Humaira, Tsuo, Kristin, Hirbo, Jibril B, Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Namba, Shinichi, Surakka, Ida, Wolford, Brooke N, Faro, Valeria Lo, Lopera-Maya, Esteban A, Läll, Kristi, Favé, Marie-Julie, Partanen, Juulia J, Chapman, Sinéad B, Karjalainen, Juha, Kurki, Mitja, Maasha, Mutaamba, Brumpton, Ben M, Chavan, Sameer, Chen, Tzu-Ting, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A, Guare, Lindsay A, Gignoux, Christopher R, Graham, Sarah E, Hornsby, Whitney E, Ingold, Nathan, Ismail, Said I, Johnson, Ruth, Laisk, Triin, Lin, Kuang, Lv, Jun, Millwood, Iona Y, Moreno-Grau, Sonia, Nam, Kisung, Palta, Priit, Pandit, Anita, Preuss, Michael H, Saad, Chadi, Setia-Verma, Shefali, Thorsteinsdottir, Unnur, Uzunovic, Jasmina, Verma, Anurag, Zawistowski, Matthew, Zhong, Xue, Afifi, Nahla, Al-Dabhani, Kawthar M, Thani, Asma Al, Bradford, Yuki, Campbell, Archie, Crooks, Kristy, de Bock, Geertruida H, Damrauer, Scott M, Douville, Nicholas J, Finer, Sarah, Fritsche, Lars G, Fthenou, Eleni, Gonzalez-Arroyo, Gilberto, Griffiths, Christopher J, Guo, Yu, Hunt, Karen A, Ioannidis, Alexander, Jansonius, Nomdo M, Konuma, Takahiro, Lee, Ming Ta Michael, Lopez-Pineda, Arturo, Matsuda, Yuta, Marioni, Riccardo E, Moatamed, Babak, Nava-Aguilar, Marco A, Numakura, Kensuke, Patil, Snehal, Rafaels, Nicholas, Richmond, Anne, Rojas-Muñoz, Agustin, Shortt, Jonathan A, Straub, Peter, Tao, Ran, Vanderwerff, Brett, Vernekar, Manvi, Veturi, Yogasudha, Barnes, Kathleen C, Boezen, Marike, Chen, Zhengming, Chen, Chia-Yen, Cho, Judy, Smith, George Davey, Finucane, Hilary K, Franke, Lude, Gamazon, Eric R, Ganna, Andrea, Gaunt, Tom R, Ge, Tian, Huang, Hailiang, and Huffman, Jennifer

Subjects
Human Genome, Genetics, Biotechnology, Generic health relevance, Good Health and Well Being, Biobank of the Americas, Biobank Japan Project, BioMe, BioVU, CanPath - Ontario Health Study, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, QSkin Sun and Health Study, Taiwan Biobank, HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, GWAS, ancestry diversity, biobank, genetic association studies, meta-analysis, phenotype harmonization
Abstract

Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.

Published
2022

7. Diving into the vertical dimension of elasmobranch movement ecology.

Author

Andrzejaczek, Samantha, Lucas, Tim, Goodman, Maurice, Hussey, Nigel, Armstrong, Amelia, Carlisle, Aaron, Coffey, Daniel, Gleiss, Adrian, Huveneers, Charlie, Jacoby, David, Meekan, Mark, Mourier, Johann, Peel, Lauren, Abrantes, Kátya, Afonso, André, Ajemian, Matthew, Anderson, Brooke, Anderson, Scot, Araujo, Gonzalo, Armstrong, Asia, Bach, Pascal, Barnett, Adam, Bennett, Mike, Bezerra, Natalia, Bonfil, Ramon, Boustany, Andre, Bowlby, Heather, Branco, Ilka, Braun, Camrin, Brooks, Edward, Brown, Judith, Burke, Patrick, Butcher, Paul, Castleton, Michael, Chapple, Taylor, Chateau, Olivier, Clarke, Maurice, Coelho, Rui, Cortes, Enric, Couturier, Lydie, Cowley, Paul, Croll, Donald, Cuevas, Juan, Curtis, Tobey, Dagorn, Laurent, Dale, Jonathan, Daly, Ryan, Dewar, Heidi, Doherty, Philip, Domingo, Andrés, Dove, Alistair, Drew, Michael, Dudgeon, Christine, Duffy, Clinton, Elliott, Riley, Ellis, Jim, Erdmann, Mark, Farrugia, Thomas, Ferreira, Luciana, Ferretti, Francesco, Filmalter, John, Finucci, Brittany, Fischer, Chris, Fitzpatrick, Richard, Forget, Fabien, Forsberg, Kerstin, Francis, Malcolm, Franks, Bryan, Gallagher, Austin, Galvan-Magana, Felipe, García, Mirta, Gaston, Troy, Gillanders, Bronwyn, Gollock, Matthew, Green, Jonathan, Green, Sofia, Griffiths, Christopher, Hammerschlag, Neil, Hasan, Abdi, Hawkes, Lucy, Hazin, Fabio, Heard, Matthew, Hearn, Alex, Hedges, Kevin, Henderson, Suzanne, Holdsworth, John, Holland, Kim, Howey, Lucy, Hueter, Robert, Humphries, Nicholas, Hutchinson, Melanie, Jaine, Fabrice, Jorgensen, Salvador, Kanive, Paul, Labaja, Jessica, Lana, Fernanda, Lassauce, Hugo, Lipscombe, Rebecca, Llewellyn, Fiona, and Macena, Bruno

Abstract

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements.

Published
2022

8. A genome-wide meta-analysis of palmoplantar pustulosis implicates TH2 responses and cigarette smoking in disease pathogenesis

Author

Abraham, Thamir, Ali, Muhmad, August, Suzannah, Baudry, David, Becher, Gabrielle, Bewley, Anthony, Brown, Victoria, Cornelius, Victoria, Ghaffar, Sharizan, Ingram, John, Kavakleiva, Svetlana, Kelly, Susan, Khorshid, Mohsen, Lachmann, Helen, Ladoyanni, Effie, McAteer, Helen, McKenna, John, Meynell, Freya, Patel, Prakash, Pink, Andrew, Powell, Kingsley, Pushparajah, Angela, Sinclair, Catriona, Wachsmuth, Rachel, Hernandez-Cordero, Ariana, Thomas, Laurent, Smail, Alice, Lim, Zhao Qin, Saklatvala, Jake R., Chung, Raymond, Curtis, Charles J., Baum, Patrick, Visvanathan, Sudha, Burden, A. David, Cooper, Hywel L., Dunnill, Giles, Griffiths, Christopher E.M., Levell, Nick J., Parslew, Richard, Reynolds, Nick J., Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Simpson, Michael, Hveem, Kristian, Barker, Jonathan N., Dand, Nick, Løset, Mari, Smith, Catherine H., and Capon, Francesca

Published
2024
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10. Investigating the impact of London’s ultra low emission zone on children’s health: children’s health in London and Luton (CHILL) protocol for a prospective parallel cohort study

Author

Tsocheva, Ivelina, Scales, James, Dove, Rosamund, Chavda, Jasmine, Kalsi, Harpal, Wood, Helen E, Colligan, Grainne, Cross, Louise, Newby, Chris, Hall, Amy, Keating, Mia, Sartori, Luke, Moon, Jessica, Thomson, Ann, Tomini, Florian, Murray, Aisling, Hamad, Wasim, Tijm, Sarah, Hirst, Alice, Vincent, Britzer Paul, Kotala, Pavani, Balkwill, Frances, Mihaylova, Borislava, Grigg, Jonathan, Quint, Jennifer K, Fletcher, Monica, Mon-Williams, Mark, Wright, John, van Sluijs, Esther, Beevers, Sean, Randhawa, Gurch, Eldridge, Sandra, Sheikh, Aziz, Gauderman, William, Kelly, Frank, Mudway, Ian S, and Griffiths, Christopher J

Published
2023
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13. Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

Author

Aevermann, Brian D., Di Domizio, Jeremy, Olah, Peter, Saidoune, Fanny, Armstrong, John M., Bachelez, Hervé, Barker, Jonathan, Haniffa, Muzlifah, Julia, Valerie, Juul, Kasper, Krishnaswamy, Jayendra Kumar, Litman, Thomas, Parsons, Ian, Sarin, Kavita Y., Schmuth, Matthias, Sierra, Michael, Simpson, Michael, Homey, Bernhard, Griffiths, Christopher E.M., Scheuermann, Richard H., and Gilliet, Michel

Published
2024
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14. Use of population-based electronic databases for the identification of patients with synchronous colorectal cancer and liver metastases potentially eligible for a surgical trial

Author

Serrano, Pablo E., Griffiths, Christopher D., Fabbro, Matthew, Jibrael, Sinan, Levine, Mark, Bhandari, Mohit, Parpia, Sameer, and Simunovic, Marko

Subjects
Metastasis -- Care and treatment, Colorectal cancer -- Care and treatment -- Patient outcomes, Clinical trials -- Evaluation, Health, Health care industry
Abstract

Background: Some population-based recruitment methods, such as registries and databases, have been used to increase enrolment in clinical trials by identifying eligible participants based on baseline characteristics; however; these methods have not been tested in surgical trials, in which accrual occurs before surgery. We evaluated the use of population-based electronic databases to identify patients who potentially could be accrued to the Simultaneous Resection of Colorectal Cancer with Synchronous Liver Metastases (RESECT) trial and compared it to the traditional methods used to accrue patients (e.g., multidisciplinary rounds, letters to community surgeons) for that same trial during the same period. Methods: An electronic database (ePath) was interrogated every 2 weeks for patients diagnosed with colorectal cancer from Feb. 1, 2017, to Mar. 30, 2019. A radiologic image database (OneView) was reviewed to identify those with liver metastases (level 1 screening). Reports were interrogated to identify potentially eligible patients for the RESECT trial (level 2 screening). A hepatobiliary surgeon reviewed radiology images to identify eligible patients for the trial (level 3 screening). The primary outcome was patient eligibility for the ongoing RESECT trial. Results: The population-based method identified 90 (11.2%) of 803 patients diagnosed with colorectal cancer over the study period. Among the 90 patients, level 2 screening identified 60 (67%) potentially eligible patients for the RESECT trial. Of the 90 patients, 18 (20%) were eligible after radiographic image review (level 3 screening). Traditional accrual methods identified 38 patients with liver metastases, 27 (71%) of whom were identified as potentially eligible on level 2 screening, and 14 (37%) of whom were deemed to be eligible on level 3 screening. Twenty-six patients were identified by both methods. Twelve patients were identified by population-based methods alone, and 8 patients by traditional methods alone. Six eligible patients were identified by both methods. Baseline characteristics were similar between the 2 groups. Conclusion: A population-based electronic database method of patient accrual was able to identify eligible participants for the RESECT trial. However, optimal accrual likely requires the use of traditional methods as well. Contexte : Certaines méthodes de recrutement populationnelles, comme l'utilisation de registres et de bases de données, ont permis d'augmenter le nombre d'inscriptions aux essais cliniques en recensant des participants admissibles en fonction de certaines caractéristiques de base. Ces méthodes n'ont toutefois pas été éprouvées pour des essais chirurgicaux, pour lesquels l'inscription se produit avant la chirurgie. Nous avons évalué l'utilisation de bases de données électroniques populationnelles pour identifier des patients qui pourraient être admissibles à l'essai de résection simultanée du cancer colorectal avec métastases hépatiques synchrones (RESECT) et nous avons comparé cette approche aux méthodes conventionnelles utilisées pour recruter les patients (p. ex., tournées multidisciplinaires, lettres aux chirurgiens du milieu communautaire), pour le même essai et au cours de la même période. Méthodes : Du 1er février 2017 au 30 mars 2019, une base de données électronique (ePath) a été interrogée toutes les 2 semaines pour repérer les patients avec un diagnostic de cancer colorectal. Une base de données d'images radiologiques (OneView) a ensuite été analysée pour repérer ceux atteints de métastases hépatiques (sélection de niveau 1). Des rapports ont été consultés pour identifier les patients potentiellement admissibles à l'essai RESECT (sélection de niveau 2). Un chirurgien hépatobiliaire a examiné les images de radiologie pour déterminer l'admissibilité des patients à l'essai (sélection de niveau 3). L'issue primaire était l'admissibilité des patients à l'essai RESECT en cours. Résultats : Avec la méthode populationnelle, 90 patients (11,2 %) ont été repérés dans un bassin de 803 patients ayant reçu un diagnostic de cancer colorectal pendant la période de l'étude. Parmi ceux-ci, 60 patients (67 %) potentiellement admissibles à l'essai RESECT ont été identifiés par la sélection de niveau 2. Des 90 patients initiaux, 18 (20 %) étaient admissibles après l'examen des images radiographiques (sélection de niveau 3). Les méthodes de recrutement conventionnelles ont identifié 38 patients atteints de métastases hépatiques, parmi lesquels 27 patients (71 %) ont été identifiés comme étant potentiellement admissibles par la sélection de niveau 2. L'admissibilité de 14 patients (37 %) a été déterminée par la sélection de niveau 3. Au total, 26 patients ont été identifiés par les 2 méthodes : 12 par les méthodes populationnelles seulement, 8 par les méthodes conventionnelles seulement, et 6 par les 2 méthodes. Les caractéristiques de base étaient semblables parmi les 2 groupes. Conclusion : Une méthode de recrutement des patients utilisant une base de données électronique populationnelle a été en mesure d'identifier les participants admissibles à un essai RESECT. Cependant, l'utilisation de méthodes conventionnelles est également nécessaire pour un recrutement optimal., About half of surgical clinical trials fail to reach their target sample size. (1) A low recruitment rate is a major barrier to the completion of clinical trials. Owing to [...]

Published
2023

16. Integrated proteomics and genomics analysis of paradoxical eczema in psoriasis patients treated with biologics

Author

Ahmed, Shehnaz, Alabas, Oras, Barker, Jonathan, Becher, Gabrielle, Bewley, Anthony, Evans, Ian, Hampton, Philip, Kirby, Brian, Kleyn, Elise, Laws, Philip, Lawson, Linda, Mackenzie, Teena, McElhone, Kathleen, McPherson, Tess, Morrison, Simon, Owen, Caroline, Pearson, Eleanor, Rashid, Amir, Reynolds, Nick, Strangfeld, Anja, Walton, Shernaz, Yiu, Zenas, Gupta, Girish, Strangfeld (chair), Anja, Weller, Richard, Zietemann, Vera, Aldoori, Nadia, Ali, Mahmud, Al-Rusan, Ahmed, Angit, Caroline, Anstey, Alex, Antony, Fiona, Archer, Charles, August, Suzanna, Balasubramaniam, Periasamy, Baudry, David, Baxter, Kay, Bonsall, Alexandra, Brown, Sara, Brown, Victoria, Burden, David, Burova, Ekaterina, Butt, Aamir, Caswell, Mel, Chapman, Anna, Cliff, Sandeep, Costache, Mihaela, Darne, Sharmela, DeGiovanni, Claudia, Desai, Trupti, Diba, Victoria, Domanne, Eva, Duckworth, Michael, Dymond, Harvey, Fahy, Caoimhe, Farwer, Susanne, Ferguson, Leila, Gkini, Maria-Angeliki, Godwin, Alison, Goulding, Jon, Hammonds, Fiona, Haque, Shaheen, Higgins, Caroline, Hood, Sue, Joseph, Teresa, Johnson, Sarah, Kalavala, Manju, Khorshid, Mohsen, Labinoti, Liberta, Lamb, Ruth, Lawson, Nicole, Layton, Alison, Lees, Tara, Levell, Nick, Lewis, Helen, Lovell, Chris, Lyon, Calum, McAteer, Helen, McBride, Sandy, McCormack, Sally, McKenna, Kevin, Mellor, Serap, Meredith, Fiona, Murphy, Ruth, Norris, Paul, Parslew, Richard, Perera, Gay, Ponnambath, Nabil, Popli, Urvi, Powell, James, Ramesh, Raakhee, Ramsay, Helen, Ranasinghe, Aruni, Reeken, Saskia, Rose, Rebecca, Rotarescu, Rada, Salvary, Ingrid, Sands, Kathy, Sinha, Tapati, Schofield, Julia, Shipman, Alexa, Siebert, Stefan, Stefanescu, Simina, Sundararaj, Kavitha, Taghipour, Kathy, Taylor, Michelle, Thomson, Michelle, Topliffe, Joanne, Verdolini, Roberto, Wachsmuth, Rachel, Wade, Martin, Wahie, Shymal, Walsh, Sarah, Wilcox, Louise, Williamson, Diane, Wright, Andrew, Al-Janabi, Ali, Martin, Paul, Khan, Adnan R., Foulkes, Amy C., Smith, Catherine H., Griffiths, Christopher E.M., Morris, Andrew P., Eyre, Steve, and Warren, Richard B.

Published
2023
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17. Influence of autozygosity on common disease risk across the phenotypic spectrum

Author

Malawsky, Daniel S., van Walree, Eva, Jacobs, Benjamin M., Heng, Teng Hiang, Huang, Qin Qin, Sabir, Ataf H., Rahman, Saadia, Sharif, Saghira Malik, Khan, Ahsan, Mirkov, Maša Umićević, Kuwahara, Hiroyuki, Gao, Xin, Alkuraya, Fowzan S., Posthuma, Danielle, Newman, William G., Griffiths, Christopher J., Mathur, Rohini, van Heel, David A., Finer, Sarah, O’Connell, Jared, and Martin, Hilary C.

Published
2023
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18. Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicenter phase 3 double-blind randomized placebo-controlled trial (ViDiKids)

Author

Middelkoop, Keren, Stewart, Justine, Walker, Neil, Delport, Carmen, Jolliffe, David A., Coussens, Anna K., Nuttall, James, Tang, Jonathan C.Y., Fraser, William D., Griffiths, Christopher J., Kumar, Geeta Trilok, Filteau, Suzanne, Hooper, Richard L., Wilkinson, Robert J., Bekker, Linda-Gail, and Martineau, Adrian R.

Published
2023
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19. Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial

Author

Morriss, Richard, Patel, Shireen, Boutry, Clement, Patel, Priya, Guo, Boliang, Briley, Paul M, Butler, Deborah, Craven, Michael, Duncan, Ashley, Griffiths, Christopher, Higton, Fred, McNaughton, Rebecca, Nixon, Neil, Prasad, Vibhore, Sayal, Kapil, Smart, David, Zafar, Azhar, and Kai, Joe

Published
2023
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22. Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Author

Zhou, Wei, Kanai, Masahiro, Wu, Kuan-Han H., Rasheed, Humaira, Tsuo, Kristin, Hirbo, Jibril B., Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Namba, Shinichi, Surakka, Ida, Wolford, Brooke N., Lo Faro, Valeria, Lopera-Maya, Esteban A., Läll, Kristi, Favé, Marie-Julie, Chapman, Sinéad B., Karjalainen, Juha, Kurki, Mitja, Mutaamba, Maasha, Partanen, Juulia J., Brumpton, Ben M., Chavan, Sameer, Chen, Tzu-Ting, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A., Gignoux, Christopher R., Graham, Sarah E., Hornsby, Whitney E., Ingold, Nathan, Johnson, Ruth, Laisk, Triin, Lin, Kuang, Lv, Jun, Millwood, Iona Y., Palta, Priit, Pandit, Anita, Preuss, Michael H., Thorsteinsdottir, Unnur, Uzunovic, Jasmina, Zawistowski, Matthew, Zhong, Xue, Campbell, Archie, Crooks, Kristy, de Bock, Geertruida H., Douville, Nicholas J., Finer, Sarah, Fritsche, Lars G., Griffiths, Christopher J., Guo, Yu, Hunt, Karen A., Konuma, Takahiro, Marioni, Riccardo E., Nomdo, Jansonius, Patil, Snehal, Rafaels, Nicholas, Richmond, Anne, Shortt, Jonathan A., Straub, Peter, Tao, Ran, Vanderwerff, Brett, Barnes, Kathleen C., Boezen, Marike, Chen, Zhengming, Chen, Chia-Yen, Cho, Judy, Smith, George Davey, Finucane, Hilary K., Franke, Lude, Gamazon, Eric R., Ganna, Andrea, Gaunt, Tom R., Ge, Tian, Huang, Hailiang, Huffman, Jennifer, Koskela, Jukka T., Lajonchere, Clara, Law, Matthew H., Li, Liming, Lindgren, Cecilia M., Loos, Ruth J.F., MacGregor, Stuart, Matsuda, Koichi, Olsen, Catherine M., Porteous, David J., Shavit, Jordan A., Snieder, Harold, Trembath, Richard C., Vonk, Judith M., Whiteman, David, Wicks, Stephen J., Wijmenga, Cisca, Wright, John, Zheng, Jie, Zhou, Xiang, Awadalla, Philip, Boehnke, Michael, Cox, Nancy J., Geschwind, Daniel H., Hayward, Caroline, Hveem, Kristian, Kenny, Eimear E., Lin, Yen-Feng, Mägi, Reedik, Martin, Hilary C., Medland, Sarah E., Okada, Yukinori, Palotie, Aarno V., Pasaniuc, Bogdan, Sanna, Serena, Smoller, Jordan W., Stefansson, Kari, van Heel, David A., Walters, Robin G., Zöllner, Sebastian, Martin, Alicia R., Willer, Cristen J., Daly, Mark J., Neale, Benjamin M., Lopera, Esteban, Kerminen, Sini, Wu, Kuan-Han, Bhatta, Laxmi, Brumpton, Ben, Deelen, Patrick, Murakami, Yoshinori, Willer, Cristen, and Hirbo, Jibril

Published
2023
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26. A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis.

Author

Hernandez-Cordero, Ariana, primary, Thomas, Laurent, additional, Smail, Alice, additional, Lim, Zhao Qin, additional, Saklatvala, Jake R., additional, Chung, Raymond, additional, Curtis, Charles J., additional, Baum, Patrick, additional, Visvanathan, Sudha, additional, Burden, A David, additional, Cooper, Hywel L., additional, Dunnill, Giles, additional, Griffiths, Christopher EM., additional, Levell, Nick J., additional, Parslew, Richard, additional, Reynolds, Nick J., additional, Wahie, Shyamal, additional, Warren, Richard B., additional, Wright, Andrew, additional, Simpson, Michael, additional, Hveem, Kristian, additional, Barker, Jonathan N., additional, Dand, Nick, additional, Loset, Mari, additional, Smith, Catherine H., additional, and Capon, Francesca, additional

Published
2024
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28. Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

Author

Zhou, Wei, Kanai, Masahiro, Wu, Kuan-Han H., Rasheed, Humaira, Tsuo, Kristin, Hirbo, Jibril B., Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Namba, Shinichi, Surakka, Ida, Wolford, Brooke N., Lo Faro, Valeria, Lopera-Maya, Esteban A., Läll, Kristi, Favé, Marie-Julie, Partanen, Juulia J., Chapman, Sinéad B., Karjalainen, Juha, Kurki, Mitja, Maasha, Mutaamba, Brumpton, Ben M., Chavan, Sameer, Chen, Tzu-Ting, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A., Guare, Lindsay A., Gignoux, Christopher R., Graham, Sarah E., Hornsby, Whitney E., Ingold, Nathan, Ismail, Said I., Johnson, Ruth, Laisk, Triin, Lin, Kuang, Lv, Jun, Millwood, Iona Y., Moreno-Grau, Sonia, Nam, Kisung, Palta, Priit, Pandit, Anita, Preuss, Michael H., Saad, Chadi, Setia-Verma, Shefali, Thorsteinsdottir, Unnur, Uzunovic, Jasmina, Verma, Anurag, Zawistowski, Matthew, Zhong, Xue, Afifi, Nahla, Al-Dabhani, Kawthar M., Al Thani, Asma, Bradford, Yuki, Campbell, Archie, Crooks, Kristy, de Bock, Geertruida H., Damrauer, Scott M., Douville, Nicholas J., Finer, Sarah, Fritsche, Lars G., Fthenou, Eleni, Gonzalez-Arroyo, Gilberto, Griffiths, Christopher J., Guo, Yu, Hunt, Karen A., Ioannidis, Alexander, Jansonius, Nomdo M., Konuma, Takahiro, Michael Lee, Ming Ta, Lopez-Pineda, Arturo, Matsuda, Yuta, Marioni, Riccardo E., Moatamed, Babak, Nava-Aguilar, Marco A., Numakura, Kensuke, Patil, Snehal, Rafaels, Nicholas, Richmond, Anne, Rojas-Muñoz, Agustin, Shortt, Jonathan A., Straub, Peter, Tao, Ran, Vanderwerff, Brett, Vernekar, Manvi, Veturi, Yogasudha, Barnes, Kathleen C., Boezen, Marike, Chen, Zhengming, Chen, Chia-Yen, Cho, Judy, Smith, George Davey, Finucane, Hilary K., Franke, Lude, Gamazon, Eric R., Ganna, Andrea, Gaunt, Tom R., Ge, Tian, Huang, Hailiang, Huffman, Jennifer, Katsanis, Nicholas, Koskela, Jukka T., Lajonchere, Clara, Law, Matthew H., Li, Liming, Lindgren, Cecilia M., Loos, Ruth J.F., MacGregor, Stuart, Matsuda, Koichi, Olsen, Catherine M., Porteous, David J., Shavit, Jordan A., Snieder, Harold, Takano, Tomohiro, Trembath, Richard C., Vonk, Judith M., Whiteman, David C., Wicks, Stephen J., Wijmenga, Cisca, Wright, John, Zheng, Jie, Zhou, Xiang, Awadalla, Philip, Boehnke, Michael, Bustamante, Carlos D., Cox, Nancy J., Fatumo, Segun, Geschwind, Daniel H., Hayward, Caroline, Hveem, Kristian, Kenny, Eimear E., Lee, Seunggeun, Lin, Yen-Feng, Mbarek, Hamdi, Mägi, Reedik, Martin, Hilary C., Medland, Sarah E., Okada, Yukinori, Palotie, Aarno V., Pasaniuc, Bogdan, Rader, Daniel J., Ritchie, Marylyn D., Sanna, Serena, Smoller, Jordan W., Stefansson, Kari, van Heel, David A., Walters, Robin G., Zöllner, Sebastian, Biobank of the Americas, Biobank Japan Project, BioMe, BioVU, CanPath - Ontario Health Study, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, The Qskin Sun and Health Study, Taiwan Biobank, The Hunt Study, Ucla Atlas Community Health Initiative, Uganda Genome Resource, Uk Biobank, Martin, Alicia R., Willer, Cristen J., Daly, Mark J., Neale, Benjamin M., and Elzur, Roy

Published
2022
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29. Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study

Author

Barker, Jonathan, Benham, Marilyn, Burden, David, Evans, Ian, Griffiths, Christopher, Hussain, Sagair, Kirby, Brian, Lawson, Linda, Mason, Kayleigh, McElhone, Kathleen, Murphy, Ruth, Ormerod, Anthony, Owen, Caroline, Reynolds, Nick, Smith, Catherine, Warren, Richard, Barker, Jonathan N.W.N., Barnes, Michael R., Burden, A. David, DiMeglio, Paola, Emsley, Richard, Evans, Andrea, Griffiths, Christopher E.M., Payne, Katherine, Reynolds, Nick J., Smith, Catherine H., Stocken, Deborah, Warren, Richard B., Loeff, Floris C., Tsakok, Teresa, Dijk, Lisanne, Hart, Margreet H., Duckworth, Michael, Baudry, David, Russell, Alice, Dand, Nick, van Leeuwen, Astrid, de Vries, Annick, Bloem, Karien, Wolbink, Gerrit Jan, and Rispens, Theo

Published
2020
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30. Treatment and Outcomes of Congenital Ovarian Cysts A Study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Author

Safa, Nadia, Yanchar, Natalie, Puligandla, Pramod, Sewitch, Maida, Baird, Robert, Beaunoyer, Mona, Campbell, Niamh, Chadha, Rati, Griffiths, Christopher, Jones, Sarah, Kaur, Manvinder, Le-Nguyen, Annie, Nasr, Ahmed, Piché, Nelson, Piper, Hannah, Prasil, Pascale, Romao, Rodrigo L.P., VanHouwelingen, Lisa, Wales, Paul, Guadagno, Elena, and Emil, Sherif

Published
2023
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32. Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis

Author

Evans, Ian, Murphy, Ruth, McPherson, Tess, Kleyn, Elise, Laws, Philip, Becher, Gabrielle, Bewley, Anthony, Rashid, Amir, Alabas, Oras, Morrison, Simon, Ahmed, Shehnaz, Pearson, Eleanor, Richards, Josh, Mackenzie, Teena, Kirby, Brian, Burden, David, Lawson, Linda, McElhone, Kathleen, Ormerod, Anthony, Owen, Caroline, Aldoori, Nadia, Ali, Mahmud, Anstey, Alex, Antony, Fiona, Archer, Charles, August, Suzanna, Balasubramaniam, Periasamy, Baxter, Kay, Bonsall, Alexandra, Brown, Victoria, Burova, Katya, Butt, Aamir, Caswell, Mel, Cliff, Sandeep, Costache, Mihaela, Darne, Sharmela, Davies, Emily, DeGiovanni, Claudia, Desai, Trupti, DeSilva, Bernadette, Diba, Victoria, Domanne, Eva, Dymond, Harvey, Fahy, Caoimhe, Ferguson, Leila, Gkini, Maria-Angeliki, Godwin, Alison, Hammonds, Fiona, Johnson, Sarah, Joseph, Teresa, Kalavala, Manju, Khorshid, Mohsen, Labinoti, Liberta, Lawson, Nicole, Layton, Alison, Lees, Tara, Levell, Nick, Lewis, Helen, Lyon, Calum, McBride, Sandy, McCormack, Sally, McKenna, Kevin, Mellor, Serap, Norris, Paul, Popli, Urvi, Perera, Gay, Ponnambath, Nabil, Ramsay, Helen, Ranasinghe, Aruni, Reeken, Saskia, Rose, Rebecca, Rotarescu, Rada, Salvary, Ingrid, Sands, Kathy, Sinha, Tapati, Stefanescu, Simina, Sundararaj, Kavitha, Taghipour, Kathy, Taylor, Michelle, Thomson, Michelle, Topliffe, Joanne, Verdolini, Roberto, Wachsmuth, Rachel, Wade, Martin, Wahie, Shyamal, Walsh, Sarah, Walton, Shernaz, Wilcox, Louise, Wright, Andrew, Douroudis, Konstantinos, Ramessur, Ravi, Barbosa, Ines A., Baudry, David, Duckworth, Michael, Angit, Caroline, Capon, Francesca, Chung, Raymond, Curtis, Charles J., Di Meglio, Paola, Goulding, Jonathan M.R., Griffiths, Christopher E.M., Lee, Sang Hyuck, Mahil, Satveer K., Parslew, Richard, Reynolds, Nick J., Shipman, Alexa R., Warren, Richard B., Yiu, Zenas Z.N., Simpson, Michael A., Barker, Jonathan N., Dand, Nick, and Smith, Catherine H.

Published
2022
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33. Differentiating congenital ovarian cysts from other abdominal cystic lesions in female infants: A study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Author

Safa, Nadia, Yanchar, Natalie, Puligandla, Pramod, Sewitch, Maida, Baird, Robert, Beaunoyer, Mona, Butter, Andreana, Campbell, Niamh, Chadha, Rati, Griffiths, Christopher, Jones, Sarah, Kaur, Manvinder, Le-Nguyen, Annie, Nasr, Ahmed, Piché, Nelson, Piper, Hannah, Prasil, Pascale, Romao, Rodrigo, VanHouwelingen, Lisa, Wales, Paul, Guadagno, Elena, Emil, Sherif, and for the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Published
2022
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38. Using electronic tagging data to investigate the individual-, population- and community-level consequences of movement in free-roaming marine fish

Author

Griffiths, Christopher A., Blackwell, Paul, Blanchard, Julia, Pitchford, Jon, and Righton, David

Subjects
597
Abstract

Tagging studies are now commonplace in ecology. Technological advances in telemetry devices have revolutionised our ability to track the movements of individual animals over vast spatial scales. This is especially true in marine ecology, where animals move through a world that is otherwise unobservable. The aim of many tagging studies is that by understanding the movements of the few we might gain some meaningful inference about the movements of the many, with clear consequences for conservation and management. Achieving this aim requires the scaling of inferences from the individual- to the population- and community-levels. Concentrating on the movements of marine fish, this scaling process forms the rationale behind this thesis. I start at the individual-level by investigating how movement influences stock structure and patterns of space use, with important implications for stock recovery. At the population-level, I introduce a novel method for behavioural classification, which addresses issues surrounding individual variation by assuming that individuals of the same species share two broad behavioural modes. Application of this method to the movements of two commercially important species reveals clear spatio-temporal patterns, as fish switch their horizontal and vertical activity levels on a seasonal basis. I step towards the community-level by first scrutinising the scaling relationship between body size and movement in marine fish before applying the findings to a dynamic size-structured community model. I show how changes to the underlying assumptions surrounding movement have large emergent consequences for community structure, species coexistence and fisheries yield. Marine tagging studies are currently underutilised by conservation and management, owing to small sample sizes, variations in data quality and a lack of methods for the scaling up of inference. Here I provide a body of work that tackles these issues and more generally demonstrates the importance of movement to our understanding of fish populations and marine communities.

Published
2018

39. The epidemiology of atopic dermatitis and psoriasis in the indigenous people of Brazil.

Author

Andrade, Débora D. B. C., Nzundu, Reagan, Rodrigues, Rodolfo R. D., Romiti, Ricardo, Santana, Yago R. T., Kurizky, Patrícia S., de Lima, Ana P. R., Carvalho, André, Ashcroft, Darren M., Gomes, Ciro M., and Griffiths, Christopher E. M.

Subjects
INDIGENOUS peoples of South America, NOSOLOGY, CITY dwellers, SPECIAL districts, INFANT mortality
Abstract

This article discusses the prevalence of atopic dermatitis (AD) and psoriasis among indigenous people in Brazil. The researchers accessed a Brazilian national database to gather information on AD and psoriasis diagnoses between 2010 and 2022. They found varying rates of AD and psoriasis across different regions of Brazil. The study highlights the importance of understanding the epidemiology of these skin conditions in indigenous populations for effective healthcare planning and interventions. The study found that the prevalence of AD and psoriasis is lower among indigenous populations compared to urban populations, particularly in remote regions like the Yanomami territory. However, it is important to note that AD and psoriasis can still occur in indigenous communities, especially those located near or within urban areas. [Extracted from the article]

Published
2024
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40. Prevalence of anxiety and depression symptoms among patients with psoriasis in Kabul, Afghanistan.

Author

Aalemi, Ahmad Khalid, Wright, Alison K., Habib, Khatera, Raofi, Nahid, Ashcroft, Darren M., and Griffiths, Christopher E. M.

Subjects
MENTAL depression, PSORIASIS, ANXIETY, MENTAL illness, INFORMED consent (Medical law)
Abstract

A study conducted at a hospital in Kabul, Afghanistan examined the prevalence of anxiety and depression symptoms among patients with psoriasis. The study included 340 individuals, with 57.1% being women and 42.9% being men, and the average age was 35.2 years. The study found that 25.9% of patients had moderate to severe anxiety symptoms, with factors such as being female, older age, low education, and multiple psoriasis symptoms being associated with these symptoms. The study also found that 31.8% of patients had moderate to severe depression symptoms, with similar factors being associated with these symptoms. The study highlights the psychological impact of psoriasis in Afghanistan and suggests the need for screening and integrated management of both dermatological and psychological factors. However, the study's limitations include its single-center, hospital-based nature. [Extracted from the article]

Published
2024
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48. Dermatology COVID-19 Registries: Updates and Future Directions

Author

Freeman, Esther E., Chamberlin, Grace C., McMahon, Devon E., Hruza, George J., Wall, Dmitri, Meah, Nekma, Sinclair, Rodney, Balogh, Esther A., Feldman, Steven R., Lowes, Michelle A., Marzano, Angelo V., Naik, Haley B., Castelo-Soccio, Leslie, Lara-Corrales, Irene, Cordoro, Kelly M., Mahil, Satveer K., Griffiths, Christopher E.M., Smith, Catherine H., Irvine, Alan D., Spuls, Phyllis I., Flohr, Carsten, and French, Lars E.

Published
2021
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