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1. Local Cerebral Blood Flow during the First Hour Following Acute Ligation of Multiple Arterioles in Rat Whisker Barrel Cortex

Author

Ling Wei, Kimberley Craven, Joseph Erinjeri, Griffith E. Liang, Daniel Bereczki, Carl M. Rovainen, Thomas A. Woolsey, and Joseph D. Fenstermacher

Subjects
AV transit time, ischemia, optical imaging, quantitative autoradiography, red blood cell flux, somatosensory cortex., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The objectives are to measure the early time-course of the flows of blood, red cells, and plasma in brain tissue destined to infarct following arterial occlusion. The flux of fluorescent red blood cells (fRBCs) through venules and the arteriovenous transit times (AVTT) of fluorescein-labeled plasma albumin were periodically monitored in anesthetized adult Wistar rats before and up to 60 min after permanent ligations of several small branches of the middle cerebral artery. Of note, fRBC is a function of venular erythrocyte flow and volume, whereas AVTT is a function of plasma flow and volume in visible arteriole–capillary–venule units. In another group of anesthetized rats, local cerebral blood flow (lCBF) was measured 1 h after permanent arterial occlusion by [14C]iodoantipyrine (IAP) autoradiography. With this model of focal ischemia, the lesion is highly reproducible and involves part of the whisker barrel cortex. Infarction of this area was observed in 12 of 13 rats. From 10 to 60 min after arterial occlusion, AVTT was nearly four times longer in the ischemic barrel cortex than at the same site before ligations, and fRBC flux was 25%. Neither parameter changed appreciably over this time. After 60 min of ischemia, lCBF on the ipsilateral barrel cortex was 18% of that on the contralateral side and 15% of the sham control value for the same area of the barrel cortex. Since whole blood flow in the ischemic barrel cortex was

Published
1998
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3. A large West Antarctic Ice Sheet explains early Neogene sea-level amplitude

Author

Marschalek, J. W., Zurli, L., Talarico, F., van de Flierdt, T., Vermeesch, P., Carter, A., Beny, F., Bout-Roumazeilles, V., Sangiorgi, F., Hemming, S. R., Pérez, L. F., Colleoni, F., Prebble, J. G., van Peer, T. E., Perotti, M., Shevenell, A. E., Browne, I., Kulhanek, D. K., Levy, R., Harwood, D., Sullivan, N. B., Meyers, S. R., Griffith, E. M., Hillenbrand, C.-D., Gasson, E., Siegert, M. J., Keisling, B., Licht, K. J., Kuhn, G., Dodd, J. P., Boshuis, C., De Santis, L., and McKay, R. M.

Published
2021
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5. Rapid state purification protocols for a Cooper pair box

Author

Griffith, E. J., Hill, C. D., Ralph, J. F., Wiseman, H. M., and Jacobs, Kurt

Subjects
Quantum Physics, Condensed Matter - Superconductivity
Abstract

We propose techniques for implementing two different rapid state purification schemes, within the constraints present in a superconducting charge qubit system. Both schemes use a continuous measurement of charge (z) measurements, and seek to minimize the time required to purify the conditional state. Our methods are designed to make the purification process relatively insensitive to rotations about the x-axis, due to the Josephson tunnelling Hamiltonian. The first proposed method, based on the scheme of Jacobs [Phys. Rev. A 67, 030301(R) (2003)] uses the measurement results to control bias (z) pulses so as to rotate the Bloch vector onto the x-axis of the Bloch sphere. The second proposed method, based on the scheme of Wiseman and Ralph [New J. Phys. 8, 90 (2006)] uses a simple feedback protocol which tightly rotates the Bloch vector about an axis almost parallel with the measurement axis. We compare the performance of these and other techniques by a number of different measures., Comment: 14 pages, 14 figures. v2: Revised version after referee comments. Accepted for publication by Physical Review B

Published
2006
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6. Spectroscopy of a Cooper-Pair box in the Autler-Townes configuration

Author

Griffith, E. J., Ralph, J. F., Greentree, Andrew D., and Clark, T. D.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics, Quantum Physics
Abstract

A theoretical spectroscopic analysis of a microwave driven superconducting charge qubit (Cooper-pair box coupled) to an RLC oscillator model is performed. By treating the oscillator as a probe through the backreaction effect of the qubit on the oscillator circuit, we extract frequency splitting features analogous to the Autler-Townes effect from quantum optics, thereby extending the analogies between superconducting and quantum optical phenomenology. These features are found in a frequency band that avoids the need for high frequency measurement systems and therefore may be of use in qubit characterization and coupling schemes. In addition we find this frequency band can be adjusted to suit an experimental frequency regime by changing the oscillator frequency., Comment: 13 pages, 7 figures. v2: Revised version after referee comments. Accepted for publication by Physical Review B

Published
2005
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7. Guidance and Control in a Josephson Charge Qubit

Author

Ralph, J. F., Griffith, E. J., Clark, T. D., and Everitt, M. J.

Subjects
Condensed Matter - Superconductivity, Quantum Physics
Abstract

In this paper we propose a control strategy based on a classical guidance law and consider its use for an example system: a Josephson charge qubit. We demonstrate how the guidance law can be used to attain a desired qubit state using the standard qubit control fields., Comment: 9 pages, 5 figures

Published
2004
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11. "Into the Hectic Unknown": Correspondence from the Archives of "The Georgia Review", 1947-76

Author

Corey, Stephen, Wade, John D., Perry, Marvin B., Rogers, J. C., Eidson, John O., Aiken, Conrad, Waugh, Evelyn, Stuart, Jesse, Hambidge, Mary C., Wheelock, John Hall, Williams, Charles D., Einstein, Albert, Wood, Junius B., O'Connor, Flannery, Lovejoy, Hatton, Davidson, W. W., Watkins, Floyd C., Ford, Jesse Hill, Dickey, James, Griffith, E. V., Crews, Harry, Connellan, Leo, Murray, Susan C., Tate, Allen, Terry, Walter S., Garrett, George, Simpson, Lewis P., Colvert, James, Irwin, John T., Gardner, John, Buck, Pearl S., Eliot, T. S., Howard, Richard, Porter, Katherine Anne, Trilling, Lionel, White, E. B., and Wilson, Edmund

Published
2006

19. Large-scale mass wasting on the miocene continental margin of Western India

Author

Dailey, S, Clift, P, Kulhanek, D, Blusztajn, J, Routledge, C, Calvès, G, O’Sullivan, P, Jonell, T, Pandey, D, Andò, S, Coletti, G, Zhou, P, Li, Y, Neubeck, N, Bendle, J, Aharonovich, S, Griffith, E, Gurumurthy, G, Hahn, A, Iwai, M, Khim, B, Kumar, A, Liddy, H, Lu, H, Lyle, M, Mishra, R, Radhakrishna, T, Saraswat, R, Saxena, R, Scardia, G, Sharma, G, Singh, A, Steinke, S, Suzuki, K, Tauxe, L, Tiwari, M, Xu, Z, Yu, Z, Dailey, Sarah K., Clift, Peter D., Kulhanek, Denise K., Blusztajn, Jerzy, Routledge, Claire M., Calvès, Gérôme, O’Sullivan, Paul, Jonell, Tara N., Pandey, Dhananjai K., SERGIO, ANDO', Coletti, Giovanni, Zhou, Peng, Li, Yuting, Neubeck, Nikki E., Bendle, James A. P., Aharonovich, Sophia, Griffith, Elizabeth M., Gurumurthy, Gundiga P., Hahn, Annette, Iwai, Masao, Khim, Boo-Keun, Kumar, Anil, Kumar, A. Ganesh, Liddy, Hannah M., Lu, Huayu, Lyle, Mitchell W., Mishra, Ravi, Radhakrishna, Tallavajhala, Saraswat, Rajeev, Saxena, Rakesh, Scardia, Giancarlo, Sharma, Girish K., Singh, Arun D., Steinke, Stephan, Suzuki, Kenta, Tauxe, Lisa, Tiwari, Manish, Xu, Zhaokai, Yu, Zhaojie, Dailey, S, Clift, P, Kulhanek, D, Blusztajn, J, Routledge, C, Calvès, G, O’Sullivan, P, Jonell, T, Pandey, D, Andò, S, Coletti, G, Zhou, P, Li, Y, Neubeck, N, Bendle, J, Aharonovich, S, Griffith, E, Gurumurthy, G, Hahn, A, Iwai, M, Khim, B, Kumar, A, Liddy, H, Lu, H, Lyle, M, Mishra, R, Radhakrishna, T, Saraswat, R, Saxena, R, Scardia, G, Sharma, G, Singh, A, Steinke, S, Suzuki, K, Tauxe, L, Tiwari, M, Xu, Z, Yu, Z, Dailey, Sarah K., Clift, Peter D., Kulhanek, Denise K., Blusztajn, Jerzy, Routledge, Claire M., Calvès, Gérôme, O’Sullivan, Paul, Jonell, Tara N., Pandey, Dhananjai K., SERGIO, ANDO', Coletti, Giovanni, Zhou, Peng, Li, Yuting, Neubeck, Nikki E., Bendle, James A. P., Aharonovich, Sophia, Griffith, Elizabeth M., Gurumurthy, Gundiga P., Hahn, Annette, Iwai, Masao, Khim, Boo-Keun, Kumar, Anil, Kumar, A. Ganesh, Liddy, Hannah M., Lu, Huayu, Lyle, Mitchell W., Mishra, Ravi, Radhakrishna, Tallavajhala, Saraswat, Rajeev, Saxena, Rakesh, Scardia, Giancarlo, Sharma, Girish K., Singh, Arun D., Steinke, Stephan, Suzuki, Kenta, Tauxe, Lisa, Tiwari, Manish, Xu, Zhaokai, and Yu, Zhaojie

Abstract

A giant mass-transport complex was recently discovered in the eastern Arabian Sea, exceeding in volume all but one other known complex on passive margins worldwide. The complex, named the Nataraja Slide, was drilled by International Ocean Discovery Program (IODP) Expedition 355 in two locations where it is ~300 m (Site U1456) and ~200 m thick (Site U1457). The top of this mass-transport complex is defined by the presence of both reworked microfossil assemblages and deformation structures, such as folding and faulting. The deposit consists of two main phases of mass wasting, each consisting of smaller pulses, with generally fining-upward cycles, all emplaced just prior to 10.8 Ma based on biostratigraphy. The base of the deposit at each site is composed largely of matrix-supported carbonate breccia that is interpreted as the product of debris-flows. In the first phase, these breccias alternate with wellsorted calcarenites deposited from a high-energy current, coherent limestone blocks that are derived directly from the Indian continental margin, and a few clastic mudstone beds. In the second phase, at the top of the deposit, muddy turbidites dominate and become increasingly more siliciclastic. At Site U1456, where both phases are seen, a 20-m section of hemipelagic mudstone is present, overlain by a ~40-m-thick section of calcarenite and slumped interbedded mud and siltstone. Bulk sediment geochemistry, heavy-mineral analysis, clay mineralogy, isotope geochemistry, and detrital zircon U-Pb ages constrain the provenance of the clastic, muddy material to being reworked, Indus-derived sediment, with input from western Indian rivers (e.g., Narmada and Tapti rivers), and some material from the Deccan Traps. The carbonate blocks found within the breccias are shallow-water limestones from the outer western Indian continental shelf, which was oversteepened from enhanced clastic sediment delivery during the mid-Miocene. The final emplacement of the material was likely related

Published
2020

21. Design of Boron-Based Peptidomimetics Leads to Potent Inhibitors of Human ClpP and ClpXP

Author

Shao W, Schimmer A, Lee R, Gennady Poda, Andrei K. Yudin, Bogdanchikova A, Griffith E, Diaz D, Tan J, Jitkova Y, and Jungberg Grouleff J

Subjects
inorganic chemicals, Chemistry, Peptidomimetic, chemistry.chemical_element, Boron, Combinatorial chemistry
Abstract

Boronic acids have attracted the attention of synthetic and medicinal chemists due to boron’s ability to modulate enzyme function. Recently, we demonstrated that boron-containing amphoteric building blocks facilitate the discovery of bioactive aminoboronic acids. Herein, we have augmented this capability with a de novo library design and virtural screening platform modified for covalent ligands. This technique has allowed us to rapidly design and identify a series of α-aminoboronic acids as the first inhibitors of human ClpXP, which is responsible for the degradation of misfolded proteins.

Published
2018

33. Minimal Competency Exam Program.

Author

Griffith, E. H.

Abstract

The high school minimal competency examination described in this document is part one of a three-part program that requires that all students satisfactorily complete tests in reading, language arts, and mathematics prior to receiving a high school diploma. The document outlines the test development and assessment program and describes the plan for phase two, that will require junior high school students to pass a minimal competency examination before entering high school, and phase three, which will test third grade students for areas of weakness before admitting them to the intermediate level. Competency goals and objectives for the high school level are listed for (1) mathematics--simple arithmetic, computation of percentages, measurement and the metric system, fractions, and the practical application of mathematics in money, budget, grocery costs, taxes, and loan interest; (2) reading--filling out forms and applications, following directions, discerning fact from opinion, reading labels, road signs, contracts, and reference materials, and identifying the main idea in a paragraph; and (3) language arts--following oral directions, spelling, writing checks, personal and business letters, the use of basic grammar, planning a speech, and recognizing the contextual meaning of words. (MAI)

Published
1977

34. Safety and effectiveness of a glistening-free single-piece hydrophobic acrylic intraocular lens (enVista)

Author

Mark Packer, James McDonald, Luther L. Fry, Louis D. Nichamin, Griffith E. Altmann, Omid Khodai, Kevin T Lavery, Brian Bearie, Jon Hayashida, and Robert Lehmann

Subjects
medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, intraocular lens, Intraocular lens, glistenings, Aphakia, Ophthalmology, Medicine, Case Series, Adverse effect, Posterior capsule opacification, Adult patients, business.industry, Clinical Ophthalmology, Phacoemulsification, cataract surgery, Cataract surgery, medicine.disease, eye diseases, enVista, hydrophobic acrylic, sense organs, medicine.symptom, business
Abstract

Mark Packer,1 Luther Fry,2 Kevin T Lavery,3 Robert Lehmann,4 James McDonald,5 Louis Nichamin,6 Brian Bearie,7,† Jon Hayashida,8 Griffith E Altmann,8 Omid Khodai8 1Department of Ophthalmology, Oregon Health and Science University, Eugene, OR, USA; 2University of Kansas Medical Center, Kansas City, KS, USA; 3Wayne State University, Detroit, MI, USA; 4Baylor College of Medicine, Houston, TX, USA; 5University of Arkansas for Medical Sciences, Little Rock, AR, USA; 6Laurel Eye Clinic, Brookville, PA, USA; 7Grand Rapids Eye Institute, Grand Rapids, MI, USA; 8Bausch & Lomb, Aliso Viejo, CA, USA †Brian Bearie passed away on March 9, 2011 Purpose: To evaluate the safety and effectiveness of a single-piece hydrophobic acrylic intraocular lens (IOL; enVista model MX60; Bausch & Lomb, Rochester, NY, USA) when used to correct aphakia following cataract extraction in adults. Methods: This was a prospective case series (NCT01230060) conducted in private practices in the US. Eligible subjects were adult patients with age-related cataract amenable to treatment with standard phacoemulsification/extracapsular cataract extraction. With follow-up of 6 months, primary safety and effectiveness end points included the rates of US Food and Drug Administration (FDA)-defined cumulative and persistent adverse events and the percentage of subjects who achieved best-corrected visual acuity (BCVA) of 20/40 or better at final visit. To evaluate rotational stability, subjects were randomized (1:1:1:1) to have the lens implanted in one of four axis positions in 45° increments. Results: A total of 122 subjects were enrolled. The rate of cumulative and persistent adverse events did not significantly exceed historical controls, as per FDA draft guidance. At the final postoperative visit, all subjects (100%) achieved a BCVA of 20/40 compared with the FDA historical control of 96.7%. Rotation of the IOL between the two final follow-up visits was ≤5° for 100% of eyes, and refractive stability was demonstrated. A low evaluation of posterior capsule opacification score was demonstrated, and no glistenings of any grade were reported for any subject at any visit. Conclusion: This study demonstrated the safety and effectiveness of the MX60 IOL. Favorable clinical outcomes included preserved BCVA, excellent rotational and refractive stability, no glistenings, and a low evaluation of posterior capsule opacification score. Keywords: cataract surgery, enVista, glistenings, intraocular lens, hydrophobic acrylic

Published
2013

38. First evidence of denitrification vis-à-vis monsoon in the Arabian Sea since Late Miocene

Author

Tripathi, S, Tiwari, M, Lee, J, Khim, B, Pandey, D, Clift, P, Kulhanek, D, Andò, S, Bendle, J, Aharonovich, S, Griffith, E, Gurumurthy, G, Hahn, A, Iwai, M, Kumar, A, Ganesh Kumar, A, Liddy, H, Lu, H, Lyle, M, Mishra, R, Radhakrishna, T, Routledge, C, Saraswat, R, Saxena, R, Scardia, G, Sharma, G, Singh, A, Steinke, S, Suzuki, K, Tauxe, L, Xu, Z, Yu, Z, Khim, BK, Pandey, DK, Clift, PD, Kulhanek, DK, Bendle, JAP, Griffith, EM, Gurumurthy, GP, Ganesh Kumar, A., Liddy, HM, Lyle, MW, Routledge, CM, Sharma, GK, Singh, AD, Tripathi, S, Tiwari, M, Lee, J, Khim, B, Pandey, D, Clift, P, Kulhanek, D, Andò, S, Bendle, J, Aharonovich, S, Griffith, E, Gurumurthy, G, Hahn, A, Iwai, M, Kumar, A, Ganesh Kumar, A, Liddy, H, Lu, H, Lyle, M, Mishra, R, Radhakrishna, T, Routledge, C, Saraswat, R, Saxena, R, Scardia, G, Sharma, G, Singh, A, Steinke, S, Suzuki, K, Tauxe, L, Xu, Z, Yu, Z, Khim, BK, Pandey, DK, Clift, PD, Kulhanek, DK, Bendle, JAP, Griffith, EM, Gurumurthy, GP, Ganesh Kumar, A., Liddy, HM, Lyle, MW, Routledge, CM, Sharma, GK, and Singh, AD

Abstract

In the Arabian Sea, South Asian monsoon (SAM)-induced high surface water productivity coupled with poor ventilation of intermediate water results in strong denitrification within the oxygen minimum zone (OMZ). Despite the significance of denitrification in the Arabian Sea, we have no long-term record of its evolution spanning the past several million years. Here, we present the first record of denitrification evolution since Late Miocene (∼10.2 Ma) in the Eastern Arabian Sea, where the SAM generates moderate surface water productivity, based on the samples retrieved during the International Ocean Discovery Program (IODP) Expedition 355. We find that (i) the SAM was persistently weaker from ∼10.2 to 3.1 Ma; it did not intensify at ∼8 Ma in contrast to a few previous studies, (ii) on tectonic timescale, both the SAM and the East Asian Monsoon (EAM) varied synchronously, (iii) the first evidence of denitrification and productivity/SAM intensification was at ∼3.2-2.8 Ma that coincided with Mid-Pliocene Warm Period (MPWP), and (iv) the modern strength of the OMZ where denitrification is a permanent feature was attained at ∼1.0 Ma.

Published
2017

42. Abstracts if Current Literature

Author

ELY, THOMAS S., QUINBY, GRIFFITH E., BATTIGELLI, M. C., PREUSS, OTTO P. G., SUTTON, WILLIAM L., POSSICK, PAUL A., KEY, MARCUS M., BIRMINGHAM, DONALD J., KINDEL, E. A., RUDNER, EARL J., ECKARDT, ROBERT E., SCHERBERGER, RICHARD F., FLOWERS, EARL S., BAIER, E. J., ROBERTS, NORBERT J., GOLDMAN, MAURICE E., McDONAGH, THOMAS J., McLEAN, ALAN, AUSTIN, ROBERT, FISCHMAN, GLORIA, ROSENTHAL, ELLEN, WEDEEN, HANNAH, WARD, W. DIXON, FLETCHER, JOHN L., COHEN, ALEXANDER, NORWOOD, W. DAGGETT, VOELZ, GEORGE L., KELLY, FRANCIS J., FULLER, J. LUTHER, MARMOR, L., TICHAUER, E. R., and BERRY, E. L.

Published
1970

43. Abstracts of Current Literature

Author

QUINBY, GRIFFITH E., RUDNER, EARL J., ECKARDT, ROBERT E., McLEAN, ALAN, FLETCHER, JOHN L., NORWOOD, W. DAGGETT, VOELZ, GEORGE L., KELLY, FRANCIS J., and TICHAUER, E. R.

Published
1971

45. Abstracts of Current Literature

Author

Birmingham, Donald J., Quinby, Griffith E., McDonagh, Thomas J., Goldman, Maurice E., Eckardt, Robert E., Norwood, W. Daggett, Voelz, George L., and Kelly, Francis J.

Published
1968

46. Abstracts of Current Literature

Author

Ely, Thomas S., Norwood, W. Daggett, Austin, Robert, McDonagh, Thomas J., Eckardt, Robert E., Birmingham, Donald J., Quinby, Griffith E., and Ward, W. Dixon

Published
1968

47. Abstracts of Current Literature

Author

ELY, THOMAS S., Gellin, Gerald A., Key, Marcus M., Birmingham, Donald J., Kindel, E. A., Miedler, Leo J., Eckardt, Robert E., Bartlett, Jay P., Lieben, Jan, Scherberger, Richard F., Flowers, Earl S., Baier, E. J., Quinby, Griffith E., Battigelli, M. C., Preuss, Otto P. G., Sutton, William L., Roberts, Norbert J., Goldman, Maurice E., McDonagh, Thomas J., Barnes, Asa, Winebrenner, John D., McLean, Alan, Austin, Robert, Fischman, Gloria, Rosenthal, Ellen, Wedeen, Hannah, Ward, W. Dixon, Fletcher, John L., Cohen, Alexander, Norwood, W. Daggett, Voelz, George L., Kelly, Francis J., Brackett, Boone, Marmor, L., Tichauer, E. R., and Berry, E. L.

Published
1969

48. Abstracts of Current Literature

Author

Quinby, Griffith E., Birmingham, Donald J., Eckardt, Robert E., Scherberger, Richard F., Flowers, Earl S., McDonagh, Thomas J., Goldman, Maurice E., Fischman, Gloria, Ely, Thomas S., Norwood, W. Daggett, Voelz, George L., and Kelly, Francis J.

Published
1969

49. Abstracts of Current Literature

Author

Quinby, Griffith E., Tichauer, E. R., Goldman, Maurice E., Norwood, W. Daggett, Miedler, Leo J., McDonagh, Thomas J., Ely, Thomas S., Lieben, Jan, Kelly, Francis J., Austin, Robert, and Barnes, Asa

Published
1968

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