17,568 results on '"Grieve A"'
Search Results
2. A Compact Quantum Random Number Generator Based on Balanced Detection of Shot Noise
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Singh, Jaideep, Piera, Rodrigo, Kurochkin, Yury, and Grieve, James A.
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Quantum Physics - Abstract
Random Number Generators are critical components of modern cryptosystems. Quantum Random Number Generators (QRNG) have emerged to provide high-quality randomness for these applications. Here we describe a scheme to extract random numbers using balanced detection of shot noise from an LED in a commercially available off-the-shelf package. The balanced detection minimizes classical noise contributions from the optical field, improving the isolation of the quantum noise. We present a detailed description and analyze the performance of a QRNG that can be easily integrated into existing systems without the requirement of custom components. The design is optimised for manufacturability, cost, and size., Comment: 5 pages, 6 figures
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- 2024
3. Polarization-encoded quantum key distribution with a room-temperature telecom single-photon emitter
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Zhang, Xingjian, Zhang, Haoran, Chua, Rui Ming, Eng, John, Meunier, Max, Grieve, James A, Gao, Weibo, and Ling, Alexander
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Quantum Physics - Abstract
Single photon sources (SPSs) are directly applicable in quantum key distribution (QKD) because they allow the implementation of the canonical BB84 protocol. To date, QKD implementations using SPS are not widespread because of the need for cryogenic operation, or frequency conversion to a wavelength efficiently transmitted over telecommunication fibers. We report an observation of polarization-encoded QKD using a room-temperature telecom SPS based on a GaN defect. A field test over 3.5 km of deployed fiber with 4.0 dB loss yielded a secure key rate of 585.9~bps. Further testing in a 32.5 km fiber spool (attenuation of 11.2 dB), which exhibited substantially lower polarization mode dispersion, yielded a secure key rate of 50.4 bps. Both results exhibited a quantum bit error rate (QBER) of approximately 5%. These results illustrate the potential of the GaN defects for supporting polarization-encoded quantum communication.
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- 2024
4. Optimising the Trade-Off Between Type I and Type II Errors: A Review and Extensions
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Grieve, Andrew P
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Statistics - Methodology - Abstract
In clinical studies upon which decisions are based there are two types of errors that can be made: a type I error arises when the decision is taken to declare a positive outcome when the truth is in fact negative, and a type II error arises when the decision is taken to declare a negative outcome when the truth is in fact positive. Commonly the primary analysis of such a study entails a two-sided hypothesis test with a type I error rate of 5% and the study is designed to have a sufficiently low type II error rate, for example 10% or 20%. These values are arbitrary and often do not reflect the clinical, or regulatory, context of the study and ignore both the relative costs of making either type of error and the sponsor's prior belief that the drug is superior to either placebo, or a standard of care if relevant. This simplistic approach has recently been challenged by numerous authors both from a frequentist and Bayesian perspective since when resources are constrained there will be a need to consider a trade-off between type I and type II errors. In this paper we review proposals to utilise the trade-off by formally acknowledging the costs to optimise the choice of error rates for simple, point null and alternative hypotheses and extend the results to composite, or interval hypotheses, showing links to the Probability of Success of a clinical study.
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- 2024
5. Low-Cost Tree Crown Dieback Estimation Using Deep Learning-Based Segmentation
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Allen, M. J., Moreno-Fernández, D., Ruiz-Benito, P., Grieve, S. W. D., and Lines, E. R.
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Computer Science - Computer Vision and Pattern Recognition ,I.4 ,I.4.6 ,I.4.8 ,I.4.9 ,I.5 ,I.5.4 - Abstract
The global increase in observed forest dieback, characterised by the death of tree foliage, heralds widespread decline in forest ecosystems. This degradation causes significant changes to ecosystem services and functions, including habitat provision and carbon sequestration, which can be difficult to detect using traditional monitoring techniques, highlighting the need for large-scale and high-frequency monitoring. Contemporary developments in the instruments and methods to gather and process data at large-scales mean this monitoring is now possible. In particular, the advancement of low-cost drone technology and deep learning on consumer-level hardware provide new opportunities. Here, we use an approach based on deep learning and vegetation indices to assess crown dieback from RGB aerial data without the need for expensive instrumentation such as LiDAR. We use an iterative approach to match crown footprints predicted by deep learning with field-based inventory data from a Mediterranean ecosystem exhibiting drought-induced dieback, and compare expert field-based crown dieback estimation with vegetation index-based estimates. We obtain high overall segmentation accuracy (mAP: 0.519) without the need for additional technical development of the underlying Mask R-CNN model, underscoring the potential of these approaches for non-expert use and proving their applicability to real-world conservation. We also find colour-coordinate based estimates of dieback correlate well with expert field-based estimation. Substituting ground truth for Mask R-CNN model predictions showed negligible impact on dieback estimates, indicating robustness. Our findings demonstrate the potential of automated data collection and processing, including the application of deep learning, to improve the coverage, speed and cost of forest dieback monitoring., Comment: 16 pages, 5 figures
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- 2024
6. Impact of polarization mode dispersion on entangled photon distribution
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Rodimin, Vadim, Kravtsov, Konstantin, Chua, Rui Ming, De Santis, Gianluca, Ponasenko, Aleksei, Kurochkin, Yury, Ling, Alexander, and Grieve, James A.
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Quantum Physics ,Physics - Optics - Abstract
Polarization mode dispersion (PMD) in optical fibers poses a major challenge for maintaining the fidelity of quantum states for quantum communications. In this work, a comprehensive model linking the probability of quantum measurement errors (infidelity) to PMD is developed and validated by experimental measurements of differential group delay and quantum bit error rate (QBER). Our research proposes effective methods to mitigate PMD effects for broadband entangled photons and evaluates the impact of higher-order PMD effects. The model provides an experimentally verified framework for the optimization of commercial quantum key distribution systems in deployed fiber optic lines., Comment: 11 pages, 8 figures, research paper
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- 2024
7. The Sociolinguistic Foundations of Language Modeling
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Grieve, Jack, Bartl, Sara, Fuoli, Matteo, Grafmiller, Jason, Huang, Weihang, Jawerbaum, Alejandro, Murakami, Akira, Perlman, Marcus, Roemling, Dana, and Winter, Bodo
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Computer Science - Computation and Language - Abstract
In this paper, we introduce a sociolinguistic perspective on language modeling. We claim that large language models are inherently models of varieties of language, and we consider how this insight can inform the development and deployment of large language models. We begin by presenting a technical definition of the concept of a variety of language as developed in sociolinguistics. We then discuss how this perspective can help address five basic challenges in language modeling: social bias, domain adaptation, alignment, language change, and scale. Ultimately, we argue that it is crucial to carefully define and compile training corpora that accurately represent the specific varieties of language being modeled to maximize the performance and societal value of large language models.
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- 2024
8. On non-Zariski density of $(D,S)$-integral points in forward orbits and the Subspace Theorem
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Grieve, Nathan and Noytaptim, Chatchai
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Mathematics - Number Theory ,Mathematics - Algebraic Geometry - Abstract
Working over a base number field $\KK$, we study the attractive question of Zariski non-density for $(D,S)$-integral points in $\mathrm{O}_f(x)$ the forward $f$-orbit of a rational point $x \in X(\KK)$. Here, $f \colon X \rightarrow X$ is a regular surjective self-map for $X$ a geometrically irreducible projective variety over $\KK$. Given a non-zero and effective $f$-quasi-polarizable Cartier divisor $D$ on $X$ and defined over $\KK$, our main result gives a sufficient condition, that is formulated in terms of the $f$-dynamics of $D$, for non-Zariski density of certain dynamically defined subsets of $\mathrm{O}_f(x)$. For the case of $(D,S)$-integral points, this result gives a sufficient condition for non-Zariski density of integral points in $\mathrm{O}_f(x)$. Our approach expands on that of Yasufuku, \cite{Yasufuku:2015}, building on earlier work of Silverman \cite{Silverman:1993}. Our main result gives an unconditional form of the main results of loc.~cit.; the key arithmetic input to our main theorem is the Subspace Theorem of Schmidt in the generalized form that has been given by Ru and Vojta in \cite{Ru:Vojta:2016} and expanded upon in \cite{Grieve:points:bounded:degree} and \cite{Grieve:qualitative:subspace}., Comment: Accepted by Journal of Number Theory
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- 2024
9. Two Stage Least Squares with Time-Varying Instruments: An Application to an Evaluation of Treatment Intensification for Type-2 Diabetes
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Tompsett, Daniel, Vansteelandt, Stijn, Grieve, Richard, Petersen, Irene, and Gomes, Manuel
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Statistics - Methodology ,Statistics - Applications - Abstract
As longitudinal data becomes more available in many settings, policy makers are increasingly interested in the effect of time-varying treatments (e.g. sustained treatment strategies). In settings such as this, the preferred analysis techniques are the g-methods, however these require the untestable assumption of no unmeasured confounding. Instrumental variable analyses can minimise bias through unmeasured confounding. Of these methods, the Two Stage Least Squares technique is one of the most well used in Econometrics, but it has not been fully extended, and evaluated, in full time-varying settings. This paper proposes a robust two stage least squares method for the econometric evaluation of time-varying treatment. Using a simulation study we found that, unlike standard two stage least squares, it performs relatively well across a wide range of circumstances, including model misspecification. It compares well with recent time-varying instrument approaches via g-estimation. We illustrate the methods in an evaluation of treatment intensification for Type-2 Diabetes Mellitus, exploring the exogeneity in prescribing preferences to operationalise a time-varying instrument., Comment: 34 Pages, 4 Figures, and 7 Tables
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- 2024
10. Parallel trusted node approach for satellite quantum key distribution
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De Santis, Gianluca, Kravtsov, Konstantin, Amairi-Pyka, Sana, and Grieve, James A.
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Quantum Physics - Abstract
Quantum key distribution (QKD) via satellite links is the only currently viable solution to create quantum-backed secure communication at a global scale. To achieve intercontinental coverage with available technology one must adopt a "flying trusted node" paradigm, in which users fully trust the satellite platform. Here, inspired by the concept of distributed secret sharing and the imminent projected launch of several QKD-equipped satellites, we propose a parallel trusted node approach, in which key distribution is mediated by several satellites in parallel. This has the effect of distributing the trust, removing single points of failure and reducing the necessary assumptions. In addition, we discuss the versatility that an optical ground station should provide to execute such a protocol and, in general, to be fully integrated into a multi-party global quantum network., Comment: 6 pages, 2 figures
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- 2024
11. A practical transmitter device for passive state BB84 quantum key distribution
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Kurochkin, Yury, Papadovasilakis, Marios, Trushechkin, Anton, Piera, Rodrigo, and Grieve, James A.
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Quantum Physics - Abstract
In prepare-and-measure quantum key distribution systems, careful preparation of quantum states within the transmitter device is a significant driver of both complexity and cost. Moreover, the security guarantees of such systems rest on the correct operation of high speed quantum random number generators (QRNGs) and the high-fidelity modulation of weak optical signals by high-speed optoelectronic devices, all of which must be hardened against a variety of known side-channel attacks. A fully passive state preparation approach elegantly resolves these problems by combining state preparation and QRNG stages into a single optical instrument. By using pairs of optical pulses from a gain-switched laser diode as ready-to-use qubits, the QKD transmitter can be radically simplified, eventually comprising a single laser and local phase tomography stage. We demonstrate our simplified transmitter by establishing a QKD link over a 10 km fiber, generating a secret key rate 110 bits/s, sufficient for practical deployment in "last mile" urban quantum networks. Our results show promise in making QKD simpler and more accessible, closing a critical technology gap in building a secure quantum communication infrastructure., Comment: 9 pages, 5 figures
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- 2024
12. Performance Evaluation of Interim Analysis in Bioequivalence Studies
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Isogawa, Naoki, Grieve, Andy, Ishii, Ryota, and Maruo, Kazushi
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- 2024
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13. ALMs: Authorial Language Models for Authorship Attribution
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Huang, Weihang, Murakami, Akira, and Grieve, Jack
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Computer Science - Computation and Language - Abstract
In this paper, we introduce an authorship attribution method called Authorial Language Models (ALMs) that involves identifying the most likely author of a questioned document based on the perplexity of the questioned document calculated for a set of causal language models fine-tuned on the writings of a set of candidate author. We benchmarked ALMs against state-of-art-systems using the CCAT50 dataset and the Blogs50 datasets. We find that ALMs achieves a macro-average accuracy score of 83.6% on Blogs50, outperforming all other methods, and 74.9% on CCAT50, matching the performance of the best method. To assess the performance of ALMs on shorter texts, we also conducted text ablation testing. We found that to reach a macro-average accuracy of 70%, ALMs needs 40 tokens on Blogs50 and 400 tokens on CCAT50, while to reach 60% ALMs requires 20 tokens on Blogs50 and 70 tokens on CCAT50.
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- 2024
14. Demonstration of a low loss, highly stable and re-useable edge coupler for high heralding efficiency and low g^(2) (0) SOI correlated photon pair sources
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Du, Jinyi, Chen, George F. R., Gao, Hongwei, Grieve, James A., Tan, Dawn T. H., and Ling, Alexander
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Physics - Optics ,Quantum Physics - Abstract
We report a stable, low loss method for coupling light from silicon-on-insulator (SOI) photonic chips into optical fibers. The technique is realized using an on-chip tapered waveguide and a cleaved small core optical fiber. The on-chip taper is monolithic and does not require a patterned cladding, thus simplifying the chip fabrication process. The optical fiber segment is composed of a centimeter-long small core fiber (UHNA7) which is spliced to SMF-28 fiber with less than -0.1 dB loss. We observe an overall coupling loss of -0.64 dB with this design. The chip edge and fiber tip can be butt coupled without damaging the on-chip taper or fiber. Friction between the surfaces maintains alignment leading to an observation of +-0.1 dB coupling fluctuation during a ten-day continuous measurement without use of any adhesive. This technique minimizes the potential for generating Raman noise in the fiber, and has good stability compared to coupling strategies based on longer UHNA fibers or fragile lensed fibers. We also applied the edge coupler on a correlated photon pair source and observed a raw coincidence count rate of 1.21 million cps and raw heralding efficiency of 21.3%. We achieved an auto correlation function g^(2) (0) as low as 0.0004 at the low pump power regime.
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- 2023
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15. Rivalry and Group Member Behavior among Fans of Sport Teams and Theme Parks
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Havard, Cody T., Baker, Carissa, Wann, Daniel L., Grieve, Frederick G., and Ryan, Timothy D.
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The current study investigated how group members react to favorite and rival brands among sport teams and theme parks. Specifically, fans of sport teams perceptions of favorite and rival brands were compared to that of theme park fans. Results showed that fans of sport teams reported more positivity toward their favorite brands and more negativity toward their rival brands than did fans of theme parks. Additionally, identifying as a fan of both a sport team and theme parks influenced more positive attitudes toward the favorite theme park brand. Finally, the current study places the group member behavior of theme park fans in the Hierarchy of Out-Group Derogation (HOD) and Out-group Derogation Spectrum (ODS) using the Group Behavior Composite (GBC, Havard, Grieve, & Peetz, 2021). Implications for research and practice are discussed, along with future research avenues presented. A version of this study was presented at a previous conference, however with inaccurate data analysis. This presentation will focus on analysis using correct data points and the inclusion of the results in the HOD and ODS.
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- 2023
16. SMARCA4-deficient primary bone sarcoma with “teratoid” features in a rhabdoid tumor predisposition syndrome patient
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Sookdeo, Jonathan, Wang, Lu, Bishop, Michael W., Grieve, LilyAnne, Perrino, Melissa, Abdelhafeez, Abdelhafeez H., Khalatbari, Hedieh, Malik, Faizan, and Koo, Selene C.
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- 2024
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17. Examining the Effectiveness of an E-Learning Training Course for Coaches of a Type 2 Diabetes Prevention Program
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Grieve, Natalie J., Cranston, Kaela D., and Jung, Mary E.
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- 2024
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18. Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation.
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Howden, N, Branch, K, Douglas, P, Gray, M, Dewey, M, Newby, D, Nicholls, S, Blankstein, R, Fathieh, S, Grieve, S, Figtree, G, and Budoff, Matthew
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CCTA ,atherosclerosis ,coronary CT ,coronary plaque ,drug development - Abstract
Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. There are numerous effective medications for modifying CAD but new pharmacologic therapies require increasingly large and expensive cardiovascular outcome trials to assess their potential impact on MACE and to obtain regulatory approval. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease. Valid surrogates of CAD are urgently needed to facilitate robust evaluation of novel, beneficial treatments and inspire investment. Fortunately, advances in non-invasive imaging offer new opportunity for accelerating CAD drug development. Coronary computed tomography angiography (CCTA) is the most advanced candidate, with the ability to measure accurately and reproducibly characterize the underlying causal disease itself. Indeed, favourable changes in plaque burden have been shown to be associated with improved outcomes, and CCTA may have a unique role as an effective surrogate endpoint for therapies that are designed to improve CAD outcomes. CCTA also has the potential to de-risk clinical endpoint-based trials both financially and by enrichment of participants at higher likelihood of MACE. Furthermore, total non-calcified, and high-risk plaque volume, and their change over time, provide a causally linked measure of coronary artery disease which is inextricably linked to MACE, and represents a robust surrogate imaging biomarker with potential to be endorsed by regulatory authorities. Global consensus on specific imaging endpoints and protocols for optimal clinical trial design is essential as we work towards a rigorous, sustainable and staged pathway for new CAD therapies.
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- 2024
19. A global investigation into antimicrobial knowledge in medicine, pharmacy, nursing, dentistry and veterinary undergraduate students: A scoping review to inform future planetary health multidisciplinary education
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Shahd Alzard, Betty Exintaris, Mahbub Sarkar, Averil Grieve, Sara Chuang, Renier Coetzee, and Angelina Lim
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Antimicrobial prescribing ,antimicrobial resistance ,antimicrobial stewardship ,knowledge ,attitude ,practice ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Inappropriate use of antimicrobials can push the environment out of balance, and cause unnecessary waste that can contaminate our soil, animals and waterways. Health professional education is committed to preparing students for antimicrobial stewardship (AMS) and supporting planetary health, but a more multidisciplinary action is needed to curb the expansion of antimicrobial resistance (AMR). The aim of this scoping review is to showcase the current antimicrobial knowledge of undergraduate students across the disciplines of medicine, pharmacy, nursing, dentistry and veterinary. This will consequently showcase the gaps and trends across the different disciplines and countries to help inform planetary health multidisciplinary undergraduate curriculums. Methods A search of the existing literature published prior to December 2023 was conducted using CINAHL, EMBASE, MEDLINE, SCOPUS, and ERIC databases. Studies were excluded if they included postgraduate students or discussed the knowledge, attitude and practice (KAP) of students towards antimicrobial prescribing, AMR and AMS related to a specific learning activity. Results A total of 144 articles were included. The most represented countries were India and Pakistan accounting for 17% and 8% of the studies, respectively. Single-disciplinary research accounted for approximately 80% of the studies. Medicine was the most represented discipline in both single-disciplinary and multidisciplinary research, appearing in approximately 62% of the studies, followed by pharmacy appearing in approximately 30% of the studies and dentistry appearing in approximately 18% of the studies. Three major priority themes were identified: students are more familiar with the term AMR compared to AMS; inappropriate use of antimicrobials is seen as the main driver of AMR; and the need for more training and education in the field of appropriate antimicrobial prescribing, AMR and AMS. Conclusion This review has highlighted that there is a need for more AMS interprofessional education (IPE) activities in all five disciplines, and especially within the disciplines of nursing, veterinary and dentistry, as shown by a lack of multidisciplinary research in this area. Most of the knowledge assessments have just touched the surface of AMS and focused on inappropriate antimicrobial use alone. Interdisciplinary planetary health education needs to go beyond these skills and broaden the understanding of other factors that can contribute to AMR such as inappropriate disposal, environmental contamination, monitoring and surveillance, one health, false allergies, and more importantly, how each health professional can contribute to a team.
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- 2024
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20. Material Afterlives: The Quilted Poetics of Daughters of the Dust (1991) and Lemonade (2016)
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Grieve, Alexandra
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- 2024
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21. Compressive single-pixel read-out of single-photon quantum walks on a polymer photonic chip
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Chandra, Aveek, Wu, Shuin Jian, Frank, Angelina, and Grieve, James A.
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Quantum Physics - Abstract
Quantum photonic devices operating in the single photon regime require the detection and characterization of quantum states of light. Chip-scale, waveguide-based devices are a key enabling technology for increasing the scale and complexity of such systems. Collecting single photons from multiple outputs at the end-face of such a chip is a core task that is frequently non-trivial, especially when output ports are densely spaced. We demonstrate a novel, inexpensive method to efficiently image and route individual output modes of a polymer photonic chip, where single photons undergo a quantum walk. The method makes use of single-pixel imaging (SPI) with a digital micromirror device (DMD). By implementing a series of masks on the DMD and collecting the reflected signal into single-photon detectors, the spatial distribution of the single photons can be reconstructed with high accuracy. We also demonstrate the feasibility of optimization strategies based on compressive sensing., Comment: 7 pages, 6 figures
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- 2023
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22. On qualitative aspects of the quantitative subspace theorem
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Grieve, Nathan
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Mathematics - Number Theory ,Mathematics - Algebraic Geometry - Abstract
We deduce Diophantine arithmetic inequalities for big linear systems and with respect to finite extensions of number fields. Our starting point is the Parametric Subspace Theorem, for linear forms, as formulated by Evertse and Ferretti \cite{Evertse:Ferretti:2013}. Among other features, this viewpoint allows for a partitioning of the linear scattering, for the Diophantine Exceptional set, that arises in the Subspace Theorem. Our perspective builds on our work \cite{Grieve:points:bounded:degree}, combined with earlier work of Evertse and Ferretti, \cite{Evertse:Ferretti:2013}, Evertse and Schlickewei, \cite{Evertse:Schlickewei:2002}, and others. As an application, we establish a novel linear scattering type result for the Diophantine exceptional set that arises in the main Diophantine arithmetic inequalities of Ru and Vojta \cite{Ru:Vojta:2016}. This result expands, refines and complements our earlier works (including \cite{Grieve:2018:autissier} and \cite{Grieve:points:bounded:degree}). A key tool to our approach is the concept of \emph{linear section} with respect to a linear system. This was defined in \cite{Grieve:points:bounded:degree}. Another point, which we develop in this article, is a notion of logarithmic \emph{twisted height functions} for local Weil functions and linear systems. As an additional observation, which is also of an independent interest, we use the theory of Iitaka fibrations to determine the asymptotic nature of such linear sections., Comment: Accepted by RMJ
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- 2023
23. Effects of Training Environment on Muscle Dysmorphia Symptomatology in Men and Women
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Schafer, Mark, Crandall, Jason, Grieve, Rick, Dispennette, Kathryn, and Michalik, Jana
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Body dysmorphic disorder -- Prognosis ,Symptomatology -- Prognosis ,Psychology and mental health ,Sports and fitness - Abstract
Muscle Dysmorphia (MD) is a condition characterized by an excessive preoccupation with muscularity. The environment in which a person resistance trains may have an impact on the clinical features of MD. The aim of this study was to compare MD symptomatology between individuals who train in traditional fitness centers (TFC) and those who train in high-intensity functional training environments (HIFT). Method: Volunteers were recruited from both TFC and HIFT facilities. Participants (N=376) completed an online (Qualtrics) demographics survey and Muscle Dysmorphia Questionnaire (MDQ). A two-way ANOVA compared the effect of training environment on MDQ scores among HIFT and TFC men and women. Results: Training environment significantly affected MDQ [F (4, 345) = 3.765, p = .005, d = 0.737]. The mean score for TFC (M = 111.73, SD = 20.39, [107.78, 115.68]) was significantly higher than HIFT (M = 102.20, SD = 19.59, [99.17, 105.23]). Discussion: Participants with greater MD symptoms may prefer training in TFC, thus potentially facilitating and perpetuating MD symptomatology. The results of the present study may provide insight into creating optimal treatment programs for individuals with clinical MD. Keywords: strength training; high intensity training; body image, Standards for attractiveness infiltrate nearly every area of popular media, constantly reinforcing the image of the ideal body. For men, the ideal body is muscular, indicating power and success (Brown [...]
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- 2024
24. American Buddhism and Technology
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Grieve, Gregory Price, Veidlinger, Daniel, Gleig, Ann, book editor, and Mitchell, Scott A., book editor
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- 2024
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25. A global investigation into antimicrobial knowledge in medicine, pharmacy, nursing, dentistry and veterinary undergraduate students: A scoping review to inform future planetary health multidisciplinary education
- Author
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Alzard, Shahd, Exintaris, Betty, Sarkar, Mahbub, Grieve, Averil, Chuang, Sara, Coetzee, Renier, and Lim, Angelina
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- 2024
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26. Spatially resolved imaging of human macular capillaries using adaptive optics-enhanced optical coherence tomography angiography
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Bonnin, S., Gocho, K., Norberg, N., Gofas, E., Lejoyeux, R., Chaumette, C., Grieve, K., Couturier, A., and Paques, M.
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- 2024
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27. Detection of capillary abnormalities in early diabetic retinopathy using scanning laser ophthalmoscopy and optical coherence tomography combined with adaptive optics
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Torm, Marie Elise Wistrup, Pircher, Michael, Bonnin, Sophie, Johannesen, Jesper, Klefter, Oliver Niels, Schmidt, Mathias Falck, Frederiksen, Jette Lautrup, Lefaudeux, Nicolas, Andilla, Jordi, Valdes, Claudia, Loza-Alvarez, Pablo, Brea, Luisa Sanchez, De Jesus, Danilo Andrade, Grieve, Kate, Paques, Michel, Larsen, Michael, and Gocho, Kiyoko
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- 2024
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28. A privacy-preserving publicly verifiable quantum random number generator
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Islam, Tanvirul, Banerji, Anindya, Boon, Chin Jia, Rui, Wang, Reezwana, Ayesha, Grieve, James A., Piera, Rodrigo, and Ling, Alexander
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- 2024
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29. The absorption-addiction model of celebrity worship: in search of a broader theoretical foundation
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Aruguete, Mara S., Grieve, Frederick, Zsila, Ágnes, Horváth, Rita, Demetrovics, Zsolt, and McCutcheon, Lynn E.
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- 2024
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30. Customised pre-operative cranioplasty to achieve maximal surgical resection of tumours with osseous involvement—a case series
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Jain, Swati, Helmy, Adel, Santarius, Thomas, Owen, Nicola, Grieve, Kirsty, Hutchinson, Peter, and Timofeev, Ivan
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- 2024
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31. Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization
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Morrow, Andrew J., Sykes, Robert, Saleh, Merna, Zahra, Baryab, MacIntosh, Alasdair, Kamdar, Anna, Bagot, Catherine, Bayes, Hannah K., Blyth, Kevin G., Bulluck, Heerajnarain, Carrick, David, Church, Colin, Corcoran, David, Findlay, Iain, Gibson, Vivienne B., Gillespie, Lynsey, Grieve, Douglas, Barrientos, Pauline Hall, Ho, Antonia, Lang, Ninian N., Lowe, David J., Lennie, Vera, Macfarlane, Peter W., Mayne, Kaitlin J., Mark, Patrick B., McConnachie, Alex, McGeoch, Ross, Nordin, Sabrina, Payne, Alexander, Rankin, Alastair J., Robertson, Keith, Ryan, Nicola, Roditi, Giles, Sattar, Naveed, Stobo, David, Allwood-Spiers, Sarah, Touyz, Rhian M., Veldtman, Gruschen, Weeden, Sarah, Weir, Robin, Watkins, Stuart, Welsh, Paul, Mangion, Kenneth, and Berry, Colin
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- 2024
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32. Construction and optimization of multi-platform precision pathways for precision medicine
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Tran, Andy, Wang, Andy, Mickaill, Jamie, Strbenac, Dario, Larance, Mark, Vernon, Stephen T., Grieve, Stuart M., Figtree, Gemma A., Patrick, Ellis, and Yang, Jean Yee Hwa
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- 2024
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33. BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures
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Geistlinger, Ludwig, Mirzayi, Chloe, Zohra, Fatima, Azhar, Rimsha, Elsafoury, Shaimaa, Grieve, Clare, Wokaty, Jennifer, Gamboa-Tuz, Samuel David, Sengupta, Pratyay, Hecht, Issac, Ravikrishnan, Aarthi, Gonçalves, Rafael S., Franzosa, Eric, Raman, Karthik, Carey, Vincent, Dowd, Jennifer B., Jones, Heidi E., Davis, Sean, Segata, Nicola, Huttenhower, Curtis, and Waldron, Levi
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- 2024
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34. Interactional competence in the online space: Affordances, challenges, and opportunities for TESOL practitioners
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Dai, David Wei, Grieve, Averil, and Yahalom, Sharon
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- 2022
35. A privacy-preserving publicly verifiable quantum random number generator
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Islam, Tanvirul, Banerji, Anindya, Boon, Chin Jia, Rui, Wang, Reezwana, Ayesha, Grieve, James A., Piera, Rodrigo, and Ling, Alexander
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Quantum Physics - Abstract
Verifying the quality of a random number generator involves performing computationally intensive statistical tests on large data sets commonly in the range of gigabytes. Limitations on computing power can restrict an end-user's ability to perform such verification. There are also applications where the user needs to publicly demonstrate that the random bits they are using pass the statistical tests without the bits being revealed. We report the implementation of an entanglement-based protocol that allows a third party to publicly perform statistical tests without compromising the privacy of the random bits., Comment: 5 pages, 4 figures, 1 table
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- 2023
36. The Letter Pi : Bayesian interpretation of p-values, Reproducibility and Considerations for Replication in the Generalized Linear Model
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Argyropoulos, Christos and Grieve, Andy P
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Statistics - Methodology ,Mathematics - Statistics Theory ,Statistics - Applications ,62P10, 62P25, 65C20, 62-04, 62A01, 62C10, 62F15 - Abstract
Significance testing based on p-values has been implicated in the reproducibility crisis in scientific research, with one of the proposals being to eliminate them in favor of Bayesian analyses. Defenders of the p-values have countered that it is the improper use and errors in interpretation, rather than the p-values themselves that are to blame. Similar exchanges about the role of p-values have occurred with some regularity every 10 to 15 years since their formal introduction in statistical practice. The apparent contradiction between the repeated failures in interpretation and continuous use of p-values suggest that there is an inferential value in the computation of these values. In this work we propose to attach a radical Bayesian interpretation to the number computed and reported as a p-value for the Generalized Linear Model, which has been the workhorse of applied statistical work. We introduce a decision analytic framework for thresholding posterior tail areas (pi-values) which for any given Bayesian analysis will have a direct correspondence to p-values in non-Bayesian approaches. Pi-values are non-controversial, posterior probability summaries of treatment effects. A predictive probability argument is made to justify the exploration of the stochastic variation (replication probability) of p and pi-values and culminates into a concrete proposal for the synthesis of Likelihood and Bayesian approaches to data analyses that aim for reproducibility. We illustrate these concepts using the results of recent randomized controlled trials in cardiometabolic and kidney diseases and provide R code for the implementation of the proposed methodology.
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- 2023
37. Geographic structure of Chinese dialects: a computational dialectometric approach
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Huang He, Grieve Jack, Jiao Lei, and Cai Zhuo
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chinese dialects ,dialectology ,dialectometry ,geolinguistics ,typology ,Philology. Linguistics ,P1-1091 - Abstract
Dialect classification is a long-standing issue in Chinese dialectology. Although various theories of Chinese dialect regions have been proposed, most have been limited by similar methodological issues, especially due to their reliance on the subjective analysis of dialect maps both individually and in the aggregate, as well as their focus on phonology over syntax and vocabulary. Consequently, we know relatively little about the geolinguistic underpinnings of Chinese dialect variation. Following a review of previous research in this area, this article presents a theory of Chinese dialect regions based on the first large-scale quantitative analysis of the data from the Linguistic Atlas of Chinese Dialects, which was collected between 2000 and 2008, providing the most up-to-date picture of the full Chinese dialect landscape. We identify and map a hierarchy of 10 major Chinese dialect regions, challenging traditional accounts. In addition, we propose a new theory of Chinese dialect formation to account for our findings.
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- 2024
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38. Spatially resolved imaging of human macular capillaries using adaptive optics-enhanced optical coherence tomography angiography
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S. Bonnin, K. Gocho, N. Norberg, E. Gofas, R. Lejoyeux, C. Chaumette, K. Grieve, A. Couturier, and M. Paques
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Retina ,Microcirculation ,Optical coherence tomography angiography ,Macula ,Fovea ,Medicine ,Science - Abstract
Abstract Documenting the organization of the retinal capillaries is of importance to understand the visual consequences of vascular diseases which may differentially affect the microvascular layers. Here we detailed the spatial organization of the macular capillaries in ten healthy human subjects using a prototypic adaptive optics-enhanced optical coherence tomography angiography (AO-OCTA) system. Within the central 6° × 6°, the radial peripapillary capillaries and the superficial, intermediate and deep vascular plexuses (SVP, IVP and DVP, respectively) were consistently resolved. In 8 out of the 10 eyes, the capillary segments composing the perifoveal arcade (PFA) were perfused only by the SVP, while drainage of the PFA showed more variability, comprising a case in which the PFA was drained by the DVP. Around the center, a distinct central avascular zone could be documented for each layer in 7 of the 10 cases; in three eyes, the IVP and SVP merged tangentially around the center. In all eyes, the foveal avascular zone was larger in the DVP than in the SVP and IVP. In one eye with incomplete separation of the inner foveal layers, there was continuity of both the SVP and the IVP; a central avascular zone was only present in the DVP. The diversity of perfusion and drainage patterns supported a connectivity scheme combining parallel and serial organizations, the latter being the most commonly observed in perifoveal vessels. Our results thus help to further characterize the diversity of organization patterns of the macular capillaries and to robustly analyze the IVP, which will help to characterize early stages of microvascular diseases.
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- 2024
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39. Detection of capillary abnormalities in early diabetic retinopathy using scanning laser ophthalmoscopy and optical coherence tomography combined with adaptive optics
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Marie Elise Wistrup Torm, Michael Pircher, Sophie Bonnin, Jesper Johannesen, Oliver Niels Klefter, Mathias Falck Schmidt, Jette Lautrup Frederiksen, Nicolas Lefaudeux, Jordi Andilla, Claudia Valdes, Pablo Loza-Alvarez, Luisa Sanchez Brea, Danilo Andrade De Jesus, Kate Grieve, Michel Paques, Michael Larsen, and Kiyoko Gocho
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Medicine ,Science - Abstract
Abstract This study tested if a high-resolution, multi-modal, multi-scale retinal imaging instrument can provide novel information about structural abnormalities in vivo. The study examined 11 patients with very mild to moderate non-proliferative diabetic retinopathy (NPDR) and 10 healthy subjects using fundus photography, optical coherence tomography (OCT), OCT angiography (OCTA), adaptive optics scanning laser ophthalmoscopy (AO-SLO), adaptive optics OCT and OCTA (AO-OCT(A)). Of 21 eyes of 11 patients, 11 had very mild NPDR, 8 had mild NPDR, 2 had moderate NPDR, and 1 had no retinopathy. Using AO-SLO, capillary looping, inflections and dilations were detected in 8 patients with very mild or mild NPDR, and microaneurysms containing hyperreflective granular elements were visible in 9 patients with mild or moderate NPDR. Most of the abnormalities were seen to be perfused in the corresponding OCTA scans while a few capillary loops appeared to be occluded or perfused at a non-detectable flow rate, possibly because of hypoperfusion. In one patient with moderate NPDR, non-perfused capillaries, also called ghost vessels, were identified by alignment of corresponding en face AO-OCT and AO-OCTA images. The combination of multiple non-invasive imaging methods could identify prominent microscopic abnormalities in diabetic retinopathy earlier and more detailed than conventional fundus imaging devices.
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- 2024
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40. Cultural Competence: 10-Year Comparison of Program Evaluators' Perceptions
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Dunaway, Krystall, Gardner, Kristine, and Grieve, Karly
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As part of its "Guiding Principles for Evaluators," the American Evaluation Association (AEA) requires that evaluators develop cultural competencies. Using a successive-independent-samples design, the researchers sought to compare perceptions of cultural competence across a duration of 10 years. Qualitative data were collected via online surveying, which included 168 program evaluators in 2009 and 110 program evaluators in 2019. Content analysis was utilized, and content categories were identified and quantified for both data collections. The data reflect that, from 2009 to 2019, there has been an increased recognition of what cultural competence entails and a closer alignment between what the "Guiding Principles for Evaluators" promotes and what evaluators demonstrate. However, the data also indicate that perhaps preferences have evolved past the current cultural competence paradigm as well as the term "cultural competence" itself. These findings and implications are discussed in further detail.
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- 2023
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41. Change in Cone Structure Over 24 Months in USH2A-Related Retinal Degeneration
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Duncan, Jacque L, Liang, Wendi, Maguire, Maureen G, Porco, Travis C, Wong, Jessica, Audo, Isabelle, Cava, Jenna A, Grieve, Kate, Kalitzeos, Angelos, Kreis, Joseph, Michaelides, Michel, Norberg, Nathaniel, Paques, Michel, Carroll, Joseph, and Group, Foundation Fighting Blindness Consortium Investigator
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Rare Diseases ,Neurosciences ,Clinical Research ,Neurodegenerative ,Eye ,Humans ,Retinal Degeneration ,Usher Syndromes ,Tomography ,Optical Coherence ,Retinal Cone Photoreceptor Cells ,Ophthalmoscopy ,Extracellular Matrix Proteins ,Foundation Fighting Blindness Consortium Investigator Group ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
PurposeTo describe cone structure changes using adaptive optics scanning laser ophthalmoscopy (AOSLO) in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study.DesignMulticenter, longitudinal natural history study.MethodsAOSLO images were acquired at 4 centers, twice at baseline and annually for 24 months in this natural history study. For each eye, at least 10 regions of interest (ROIs) with ≥50 contiguous cones were analyzed by masked, independent graders. Cone spacing Z-scores, standard deviations from the normal mean at the measured location, were compared between graders and tests at baseline. The association of cone spacing with clinical characteristics was assessed using linear mixed effects regression models weighted by image quality score. Annual rates of change were calculated based on differences between visits.ResultsFourteen eyes of 14 participants were imaged, with 192 ROIs selected at baseline. There was variability among graders, which was greater in images with lower image quality score (P < .001). Cone spacing was significantly correlated with eccentricity, quality score, and disease duration (P < .02). On average, the cone spacing Z-score increased 0.14 annually (about 9%, P < .001). We observed no significant differences in rate of change between disease type (Usher syndrome or retinitis pigmentosa), imaging site, or grader.ConclusionsUsing current methods, the analysis of quantitative measures of cone structure showed some challenges, yet showed promise that AOSLO images can be used to characterize progressive change over 24 months. Additional multicenter studies using AOSLO are needed to advance cone mosaic metrics as sensitive outcome measures for clinical trials. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.
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- 2023
42. Correction to: Performance Evaluation of Interim Analysis in Bioequivalence Studies: Naoki Isogawa
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Isogawa, Naoki, Grieve, Andy, Ishii, Ryota, and Maruo, Kazushi
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- 2024
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43. Interface Self-Referenced Dynamic Full-Field Optical Coherence Tomography
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Monfort, Tual, Azzollini, Salvatore, Yacoub, Tasnim Ben, Audo, Isabelle, Reichman, Sacha, Grieve, Kate, and Thouvenin, Olivier
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Physics - Optics ,Physics - Biological Physics ,Quantitative Biology - Subcellular Processes - Abstract
Dynamic full-field optical coherence tomography (D-FFOCT) has recently emerged as an invaluable live label-free and non-invasive imaging modality able to image subcellular biological structures and their metabolic activity within complex 3D samples. However, D-FFOCT suffers from fringe artefacts when imaging nearby reflective surfaces and is highly sensitive to vibrations. Here, we present interface Self-Referenced (iSR) D-FFOCT, an alternative configuration to D-FFOCT that takes advantage of the presence of the sample coverslip in between the sample and the objective by using it as a defocused reference arm, thus avoiding the aforementioned artefacts. We demonstrate the ability of iSR D-FFOCT to image 2D fibroblast cell cultures, which are among the flattest mammalian cells.
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- 2023
44. Dynamic Full-Field Optical Coherence Tomography module adapted to commercial microscopes for longitudinal in vitro cell culture study
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Monfort, Tual, Azzollini, Salvatore, Brogard, Jeremy, Clémençon, Marilou, Slembrouck-Brec, Amélie, Forster, Valerie, Picaud, Serge, Goureau, Olivier, Reichman, Sacha, Thouvenin, Olivier, and Grieve, Kate
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Quantitative Biology - Quantitative Methods ,Physics - Medical Physics ,Physics - Optics - Abstract
Dynamic full-field optical coherence tomography (D-FFOCT) has recently emerged as a label-free imaging tool, capable of resolving cell types and organelles within 3D live samples, whilst monitoring their activity at tens of milliseconds resolution. Here, a D-FFOCT module design is presented which can be coupled to a commercial microscope with a stage top incubator, allowing non-invasive label-free longitudinal imaging over periods of minutes to weeks on the same sample. Long term volumetric imaging on human induced pluripotent stem cell-derived retinal organoids is demonstrated, highlighting tissue and cell organisation as well as cell shape, motility and division. Imaging on retinal explants highlights single 3D cone and rod structures. An optimal workflow for data acquisition, postprocessing and saving is demonstrated, resulting in a time gain factor of 10 compared to prior state of the art. Finally, a method to increase D-FFOCT signal-to-noise ratio is demonstrated, allowing rapid organoid screening.
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- 2023
45. AI applications in forest monitoring need remote sensing benchmark datasets
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Lines, Emily R., Allen, Matt, Cabo, Carlos, Calders, Kim, Debus, Amandine, Grieve, Stuart W. D., Miltiadou, Milto, Noach, Adam, Owen, Harry J. F., and Puliti, Stefano
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Computer Science - Artificial Intelligence ,Computer Science - Computers and Society - Abstract
With the rise in high resolution remote sensing technologies there has been an explosion in the amount of data available for forest monitoring, and an accompanying growth in artificial intelligence applications to automatically derive forest properties of interest from these datasets. Many studies use their own data at small spatio-temporal scales, and demonstrate an application of an existing or adapted data science method for a particular task. This approach often involves intensive and time-consuming data collection and processing, but generates results restricted to specific ecosystems and sensor types. There is a lack of widespread acknowledgement of how the types and structures of data used affects performance and accuracy of analysis algorithms. To accelerate progress in the field more efficiently, benchmarking datasets upon which methods can be tested and compared are sorely needed. Here, we discuss how lack of standardisation impacts confidence in estimation of key forest properties, and how considerations of data collection need to be accounted for in assessing method performance. We present pragmatic requirements and considerations for the creation of rigorous, useful benchmarking datasets for forest monitoring applications, and discuss how tools from modern data science can improve use of existing data. We list a set of example large-scale datasets that could contribute to benchmarking, and present a vision for how community-driven, representative benchmarking initiatives could benefit the field.
- Published
- 2022
46. Impedance Spectroscopy of Lithium Intercalation into Cathode Materials in Coin Cells
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Göktug Yesilbas, Daniel Grieve, David Rettmann, Kivanc Gülderen, Aliaksandr S. Bandarenka, and Jeongsik Yun
- Subjects
Solid electrolyte interface ,Impedance spectroscopy ,Li-ion batteries ,Cathodes ,Equivalent circuit ,Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
Abstract Understanding the internal reactions in Li‐ion batteries is crucial to analyze them more accurately and improve their efficiency since they are involved in almost every aspect of everyday life. Electrochemical impedance spectroscopy is a valuable research technique to investigate such batteries, as it reveals sensitive properties and essential information about cell reaction mechanisms and kinetics. Physical understanding of the electrochemical process and system of a battery can be analyzed using equivalent electric circuits (EECs) with rational selection of electric circuit elements and their combination. However, impedance analysis of a battery is often conducted using oversimplified EEC models in practice due to the complexity and difficulty of the physics and mathematics of the modeling. This study proposes and verifies an EEC model that represents a three‐stage mechanism for intercalation‐type materials. For the systematic model study and verifications, we investigated cathode half cells using four different layered structured cathode materials, namely, LiCoO2, LiNi1/3Mn1/3Co1/3O2, LiNi0.9Mn0.05Co0.05O2, and Ni0.815Co0.15Al0.035O2. Parametric analysis of the impedance fittings for the four different cathode materials showed similar behavior depending on the states of charge. We also provided the complete set of parameters of the four systems: charge transfer resistance, double‐layer capacitance, and solid‐electrolyte interphase (SEI) resistance and capacitance. Lastly, we explain how different electrochemical processes, such as intercalation and alloying, can be analyzed and modeled in EEC models.
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- 2024
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47. Exploring methods for generating synthetic data in Scotland to improve access to public sector data for research
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Aileen Grieve and Nora Cooke O'Dowd
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Demography. Population. Vital events ,HB848-3697 - Abstract
Objective and Approach We are working to improve the economic, social and environmental wellbeing in Scotland by enabling access to and linkage of public-sector data for research in the public good. Our objective was to examine how synthetic data can support this aim by allowing researchers to test approaches and write code while awaiting the necessary permissions to use the real data. We have explored generating synthetic data from metadata and from actual data. Results Through engagement, researchers expressed interest in low fidelity data, which minimises privacy and information governance risks. We have created low fidelity data from information provided by data controllers in publicly-available data dictionaries. We have also created more high-fidelity data based on actual data, using the synthpop tool. We are carrying out further work to engage with data controllers about the level of fidelity that is acceptable to them, as well as the information that needs to be included in the data dictionary to meet this in an automated way, and how we will share datasets with researchers. A key part of these considerations is the ability to link synthetic datasets and the impact that has on the fidelity of the data. Conclusions and Implications We will share our approaches, the limitations we have found in using metadata to create synthetic data, difficulties encountered in using the synthpop tool, engagement we have had from controllers and researchers, and the proposed way forward for synthetic data in Scotland.
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- 2024
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48. Editorial: Collaboration, training and funding for the professional development of teachers of EAL/D students
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Grieve, Averil, Yahalom, Sharon, and Dai, David Wei
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- 2022
49. Cost-effectiveness of craniotomy versus decompressive craniectomy for UK patients with traumatic acute subdural haematoma
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Emma Toman, David K Menon, Antonio Belli, Sridevi Nagarajan, Julie Woodfield, Ruichong Ma, Jason J Chang, Jonathan Cook, Mark Kotter, Vin Shen Ban, Martin Smith, John D Pickard, Diederik Bulters, Giles Critchley, Damian Holliman, Nicole Keong, Andrew King, Catherine McMahon, Carole Turner, Peter Whitfield, Mark Wilson, Melvin Stone, Paul Brennan, David Turner, Garry Barton, Rasheed Zakaria, Angelos G Kolias, Simon Shaw, Sean Christie, Dmitri Shastin, Allison Hirst, Soumya Mukherjee, Gareth Roberts, Simon Thomson, Peter J Hutchinson, Alexis Joannides, Emanuel Cirstea, Ashish Bindra, Vairavan Narayanan, David Menon, Francesca Hill, Ashwin Kumaria, Franco Servadei, Rhys Thomas, Midhun Mohan, Silvia Tarantino, Ioana Moldovan, Sara Venturini, Tariq Khan, Marianne Hare, Louise Young, Joan Grieve, Ardalan Zolnourian, Paula Carroll, Diederik Oliver Bulters, Mathew Guilfoyle, Lisa Julien, Barbara Gregson, Martin Hunn, Richard Nelson, Stuart Smith, Shahid Khan, András Büki, Deepak Gupta, Christos Tolias, David A Turner, Christopher Madden, Paul Johnston, Peter John Hutchinson, Patrick Holton, Panagiota Gkolia, Nicola Owen, Kesava Reddy, Hani Marcus, Ibrahim Jalloh, Shabin Joshi, Ian Anderson, Himanshu Shekhar, Daniel Holsgrove, Erin Lewis, Tracey Moore, Marios C Papadopoulos, Paula Kareclas, Peter Kirkpatrick, Laura Parker, Martina Stippler, Sarah Pyne, Peter J Kirkpatrick, James Piercy, Neil Davidson, Prasanna Epaliyanage, Barbara A Gregson, Christopher Uff, Malik Zaben, Charlotte Eglinton, Linetty Makawa, Jane Perez, Louise Harrison, Mutwakil Abdulla, Garry R Barton, Mathew Joseph, Anthony Bell, Sarah Trippier, Michael Canty, Jonathan Pollock, Manjul Tripathi, Harry Mee, Ivan Timofeev, Ellie Edlmann, Nadia Scantlebury, Joseph Frantzias, Yahia Al-Tamimi, Kismet Hossain-Ibrahim, Ciaran Hill, Elisa Visentin, Sonia Raj, Ioannis Fouyas, Siobhan Kearney, Karen Caldwell, Tamara Tajsic, Belinda Gunning, Emma Clarkson, Manjunath Prasad, Mary Kambafwile, Tim Lawrence, Emily Galea, Sebastian Ille, Hadie Adams, Shumaila Hasan, Matthew G Stovell, Edoardo Viaroli, Adel E Helmy, Ivan S Timofeev, Kirsty Grieve, Liz Corteen, Janet Corn, Mohammad Naushahi, Richard Mair, Kamila Walker, Selma Tülü, Chipo Chitsenega, Geetha Boyapati, Muhammad Bhatti, Natalia Ermalai, Joseph Merola Liudmila, Laurence Glanz, Lani Patterson, Colin Bergin, Maximina Ventura, Laura Ortiz-Ruiz de Gordoa, Husam Georges, Sam Jeffrey, Natasha Wilmhurst, Philip Kane, Geraint Sunderland, John Kitchen, Mathew JosephMathew JosephGallagher, Sonia Fernandez Lopez, Andrea D’Mello, Jo-Anna Conyngham, Miriam Taylor, Charlaine Reeve, Vasileios Arzoglou, Arif Zafar, Efosa Ukponmwan, Anastasios Giamouriadis, Adam Wahba, Patrick Easton, Rose Clegg, Grace Cole, Louise Finlay, Alex Leggate, Terrie-Louise Cromie, Javier Magan Ventura, Ruth Womer, Beverley Fulkner, Geraldine Ward, Kareen Damley, Emma Fleming, Roddy O’Kane, Indira Devi Bhagavatula, Dhananjaya Ishwar Bhat, Dhaval Prem Shukla, Kanti Konar, Nagesh Shanhag, Vaishali Nl Valluri, Manoj Kumar Tewari, Kaveri Sharma, Christine Lock, Chen Min Wei, Julian Han, Janell Kwok, Nicolas Kon, Kam King, Emmalin Nelton, Louis Anthony Whitworth, Sonja Stutzman, Caryn Harper, Alice Salazar, Rocco Armonda, George B Moses, Patricia Tanjucto, Jamie Ullman, Orseola Arapi, Betsy Moclair, Nrupen Baxi, John Adair Prall, Meghan Baldwin, Jamie Jones, Clare Gallagher, Ish Bains, Leodante Da Costa, Fahad Alkherayf, Rafael Ochoa Sanchez, Kostas Fountas, Thanasis Paschalis, Sandro Krieg, Maria Luisa, Gandia Gomez, Alfonso Legares, Ana Maria Castaño Leon, Gábor Lenzsér, Mukhtar Khan, Massimo Tomei, Ronie Romelean Jayapalan, Sarah C Pyne, A David Mendelow, Christopher Cowie, Carol Davis-Wilkie, Tapiwa Tungamirai, Kerstin Wolf, Natalia Igosheva, Alicia Gore, Michele Jillings, Christopher Bushell, and Peter McCabe
- Subjects
Medicine - Abstract
Objective To estimate the cost-effectiveness of craniotomy, compared with decompressive craniectomy (DC) in UK patients undergoing evacuation of acute subdural haematoma (ASDH).Design Economic evaluation undertaken using health resource use and outcome data from the 12-month multicentre, pragmatic, parallel-group, randomised, Randomised Evaluation of Surgery with Craniectomy for Patients Undergoing Evacuation-ASDH trial.Setting UK secondary care.Participants 248 UK patients undergoing surgery for traumatic ASDH were randomised to craniotomy (N=126) or DC (N=122).Interventions Surgical evacuation via craniotomy (bone flap replaced) or DC (bone flap left out with a view to replace later: cranioplasty surgery).Main outcome measures In the base-case analysis, costs were estimated from a National Health Service and Personal Social Services perspective. Outcomes were assessed via the quality-adjusted life-years (QALY) derived from the EuroQoL 5-Dimension 5-Level questionnaire (cost-utility analysis) and the Extended Glasgow Outcome Scale (GOSE) (cost-effectiveness analysis). Multiple imputation and regression analyses were conducted to estimate the mean incremental cost and effect of craniotomy compared with DC. The most cost-effective option was selected, irrespective of the level of statistical significance as is argued by economists.Results In the cost-utility analysis, the mean incremental cost of craniotomy compared with DC was estimated to be −£5520 (95% CI −£18 060 to £7020) with a mean QALY gain of 0.093 (95% CI 0.029 to 0.156). In the cost-effectiveness analysis, the mean incremental cost was estimated to be −£4536 (95% CI −£17 374 to £8301) with an OR of 1.682 (95% CI 0.995 to 2.842) for a favourable outcome on the GOSE.Conclusions In a UK population with traumatic ASDH, craniotomy was estimated to be cost-effective compared with DC: craniotomy was estimated to have a lower mean cost, higher mean QALY gain and higher probability of a more favourable outcome on the GOSE (though not all estimated differences between the two approaches were statistically significant).Ethics Ethical approval for the trial was obtained from the North West—Haydock Research Ethics Committee in the UK on 17 July 2014 (14/NW/1076).Trial registration number ISRCTN87370545.
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- 2024
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50. Tree Genera Classifications in Spain Using Time-Series Sentinel-2 Data Extracted from Plottosat.
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Milto Miltiadou, Emily R. Lines, Stuart W. D. Grieve, Paloma Ruiz-Benito, Julen Astigarraga, and Verónica Cruz
- Published
- 2024
- Full Text
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